Free for academic non-profit institutions. Other users need a Commercial license

Aliases for YWHAG Gene

Aliases for YWHAG Gene

  • Tyrosine 3-Monooxygenase/Tryptophan 5-Monooxygenase Activation Protein Gamma 2 3 5
  • Tyrosine 3-Monooxygenase/Tryptophan 5-Monooxygenase Activation Protein, Gamma Polypeptide 2 3
  • Protein Phosphatase 1, Regulatory Subunit 170 2 3
  • Protein Kinase C Inhibitor Protein 1 3 4
  • KCIP-1 3 4
  • 14-3-3 Protein Gamma 3
  • 14-3-3 Gamma 2
  • 14-3-3GAMMA 3
  • PPP1R170 3

External Ids for YWHAG Gene

Previous GeneCards Identifiers for YWHAG Gene

  • GC07M074491
  • GC07M075554
  • GC07M075568
  • GC07M075600
  • GC07M075794
  • GC07M075956
  • GC07M071042

Summaries for YWHAG Gene

Entrez Gene Summary for YWHAG Gene

  • This gene product belongs to the 14-3-3 family of proteins which mediate signal transduction by binding to phosphoserine-containing proteins. This highly conserved protein family is found in both plants and mammals, and this protein is 100% identical to the rat ortholog. It is induced by growth factors in human vascular smooth muscle cells, and is also highly expressed in skeletal and heart muscles, suggesting an important role for this protein in muscle tissue. It has been shown to interact with RAF1 and protein kinase C, proteins involved in various signal transduction pathways. [provided by RefSeq, Jul 2008]

GeneCards Summary for YWHAG Gene

YWHAG (Tyrosine 3-Monooxygenase/Tryptophan 5-Monooxygenase Activation Protein Gamma) is a Protein Coding gene. Diseases associated with YWHAG include Creutzfeldt-Jakob Disease. Among its related pathways are DNA Damage and Regulation of PLK1 Activity at G2/M Transition. GO annotations related to this gene include poly(A) RNA binding and protein kinase C binding. An important paralog of this gene is YWHAH.

UniProtKB/Swiss-Prot for YWHAG Gene

  • Adapter protein implicated in the regulation of a large spectrum of both general and specialized signaling pathways. Binds to a large number of partners, usually by recognition of a phosphoserine or phosphothreonine motif. Binding generally results in the modulation of the activity of the binding partner.

Tocris Summary for YWHAG Gene

  • 14.3.3 proteins are a group of highly conserved proteins that are involved in many vital cellular processes such as metabolism, protein trafficking, signal transduction, apoptosis and cell cycle regulation. 14.3.3 proteins are phospho-serine/-threonine binding proteins.

Gene Wiki entry for YWHAG Gene

Additional gene information for YWHAG Gene

No data available for CIViC summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for YWHAG Gene

Genomics for YWHAG Gene

Regulatory Elements for YWHAG Gene

Enhancers for YWHAG Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH07H075734 1.2 Ensembl ENCODE 4.4 +624.2 624162 1.1 HDGF PKNOX1 ATF1 ARNT ZFP64 FEZF1 TCF12 GTF3C2 ZNF766 GATA2 PMS2P3 NSUN5P1 STAG3L1 SPDYE5 DTX2 YWHAG GTF2IP1 GC07M075740 GC07M075738 ENSG00000279996
GH07H075670 1.1 Ensembl ENCODE 4.7 +687.7 687739 1.6 HDAC1 HDGF PKNOX1 ARNT NFXL1 ZBTB40 CHAMP1 ATF7 SMARCA5 NCOA1 CCL24 HIP1 YWHAG SPDYE12P ENSG00000279996 GC07M075738 GC07M075740
GH07H075711 0.9 Ensembl ENCODE 5.2 +647.1 647061 1.9 BCOR SMARCA5 CEBPB MCM5 ZNF318 ZNF366 ZSCAN5C ZNF24 MLLT1 PRDM1 DTX2 STAG3L1 HIP1 YWHAG GC07M075740 GC07M075738 ENSG00000279996
GH07H075716 0.8 Ensembl ENCODE 4.7 +641.7 641690 1 ZNF121 JUND FOXA2 CEBPB FOS CUX1 YWHAG GC07M075738 GC07M075740 ENSG00000279996
GH07H076356 1.4 ENCODE dbSUPER 0.7 +0.4 420 4.7 HDGF PKNOX1 ARNT ARID4B SIN3A DMAP1 ZNF2 YY1 SLC30A9 ZNF766 PMS2P3 POMZP3 STAG3L1 SPDYE18 PMS2P9 DTX2P1 FAM185BP LOC100133091 NSUN5P1 SPDYE5
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around YWHAG on UCSC Golden Path with GeneCards custom track

Promoters for YWHAG Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000213910 531 2601 HDGF PKNOX1 ARNT ARID4B SIN3A DMAP1 ZNF2 YY1 SLC30A9 ZNF766

Genomic Locations for YWHAG Gene

Genomic Locations for YWHAG Gene
chr7:76,326,791-76,359,031
(GRCh38/hg38)
Size:
32,241 bases
Orientation:
Minus strand
chr7:75,956,108-75,988,348
(GRCh37/hg19)

Genomic View for YWHAG Gene

Genes around YWHAG on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
YWHAG Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for YWHAG Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for YWHAG Gene

Proteins for YWHAG Gene

  • Protein details for YWHAG Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P61981-1433G_HUMAN
    Recommended name:
    14-3-3 protein gamma
    Protein Accession:
    P61981
    Secondary Accessions:
    • O70457
    • P35214
    • Q6FH52
    • Q9UDP2
    • Q9UN99

    Protein attributes for YWHAG Gene

    Size:
    247 amino acids
    Molecular mass:
    28303 Da
    Quaternary structure:
    • Homodimer. Interacts with SAMSN1 (By similarity). Interacts with RAF1, SSH1 and CRTC2/TORC2. Interacts with ABL1 (phosphorylated form); the interaction retains it in the cytoplasm. Interacts with GAB2. Interacts with MDM4 (phosphorylated); negatively regulates MDM4 activity toward TP53. Interacts with PKA-phosphorylated AANAT and SIRT2.Interacts with the Thr-369 phosphorylated form of DAPK2 (PubMed:26047703). Interacts with PI4KB, TBC1D22A and TBC1D22B (PubMed:23572552). Interacts with SLITRK1 (PubMed:19640509).

    Three dimensional structures from OCA and Proteopedia for YWHAG Gene

neXtProt entry for YWHAG Gene

Post-translational modifications for YWHAG Gene

Other Protein References for YWHAG Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for YWHAG Gene

Domains & Families for YWHAG Gene

Gene Families for YWHAG Gene

HGNC:
Human Protein Atlas (HPA):
  • Plasma proteins
  • Predicted intracellular proteins

Protein Domains for YWHAG Gene

Graphical View of Domain Structure for InterPro Entry

P61981

UniProtKB/Swiss-Prot:

1433G_HUMAN :
  • Belongs to the 14-3-3 family.
Family:
  • Belongs to the 14-3-3 family.
genes like me logo Genes that share domains with YWHAG: view

Function for YWHAG Gene

Molecular function for YWHAG Gene

GENATLAS Biochemistry:
tyrosine 3-monooxygenase/trytophan 5 monooxygenase activation protein,14-3-3 G, highly expressed in brain,skeletal muscles,heat,located telomeric to D7S1870 at the most telomeric end of the common deletion of WBS1,multifunctional regulator involved in cell-cyle control (checkpoint) and signal transduction,inhibitor of apoptosis through inhibiting the activation of p38 MAP kinase
UniProtKB/Swiss-Prot Function:
Adapter protein implicated in the regulation of a large spectrum of both general and specialized signaling pathways. Binds to a large number of partners, usually by recognition of a phosphoserine or phosphothreonine motif. Binding generally results in the modulation of the activity of the binding partner.

Phenotypes From GWAS Catalog for YWHAG Gene

Gene Ontology (GO) - Molecular Function for YWHAG Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003723 RNA binding IDA 22658674
GO:0005080 protein kinase C binding IPI 10433554
GO:0005159 insulin-like growth factor receptor binding IPI 12482592
GO:0005515 protein binding IPI 11237865
GO:0008426 protein kinase C inhibitor activity NAS 10433554
genes like me logo Genes that share ontologies with YWHAG: view
genes like me logo Genes that share phenotypes with YWHAG: view

Animal Models for YWHAG Gene

MGI Knock Outs for YWHAG:

Animal Model Products

CRISPR Products

Inhibitory RNA Products

Clone Products

  • Addgene plasmids for YWHAG

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for YWHAG Gene

Localization for YWHAG Gene

Subcellular locations from UniProtKB/Swiss-Prot for YWHAG Gene

Cytoplasm.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for YWHAG gene
Compartment Confidence
extracellular 5
cytosol 5
cytoskeleton 3
mitochondrion 3
nucleus 3
golgi apparatus 1

Gene Ontology (GO) - Cellular Components for YWHAG Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm IEA --
GO:0005739 mitochondrion IEA --
GO:0005829 cytosol TAS --
GO:0005925 focal adhesion IDA 21423176
GO:0016020 membrane IDA 19946888
genes like me logo Genes that share ontologies with YWHAG: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for YWHAG Gene

Pathways & Interactions for YWHAG Gene

genes like me logo Genes that share pathways with YWHAG: view

Pathways by source for YWHAG Gene

SIGNOR curated interactions for YWHAG Gene

Is activated by:

Gene Ontology (GO) - Biological Process for YWHAG Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000086 G2/M transition of mitotic cell cycle TAS --
GO:0006469 negative regulation of protein kinase activity NAS 10433554
GO:0006605 protein targeting IEA --
GO:0009966 regulation of signal transduction NAS 10433554
GO:0010389 regulation of G2/M transition of mitotic cell cycle TAS --
genes like me logo Genes that share ontologies with YWHAG: view

Drugs & Compounds for YWHAG Gene

(2) Drugs for YWHAG Gene - From: ApexBio and HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Zolpidem Approved Pharma Full agonist, Allosteric regulator 105
R18 Pharma 14.3.3 proteins Antagonist 0

(2) Additional Compounds for YWHAG Gene - From: HMDB

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
Sepiapterin
  • (S)-2-amino-7,8-dihydro-6-(2-hydroxy-1-oxopropyl)-4(1H)-Pteridinone
  • 1-(2-Amino-7,8-dihydro-4-hydroxy-6-pteridinyl)-2-hydroxy-1-Propanone
  • 2-Amino-6-(S)-lactoyl-7,8-dihydro-4(3H)-pteridinone
  • 2-Amino-7,8-dihydro-6-[(2S)-2-hydroxy-1-oxopropyl]-4(1H)Pteridinone
  • L-Sepiapterin
17094-01-8

(2) Tocris Compounds for YWHAG Gene

Compound Action Cas Number
Difopein High affinity inhibitor of 14.3.3 proteins; induces apoptosis 396834-58-5
R18 Inhibitor of 14.3.3 proteins 211364-78-2

(1) ApexBio Compounds for YWHAG Gene

Compound Action Cas Number
R18 14.3.3 proteins Antagonist 211364-78-2
genes like me logo Genes that share compounds with YWHAG: view

Drug Products

Transcripts for YWHAG Gene

mRNA/cDNA for YWHAG Gene

(1) REFSEQ mRNAs :
(7) Additional mRNA sequences :
(451) Selected AceView cDNA sequences:
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for YWHAG Gene

Tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, gamma polypeptide:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

  • Addgene plasmids for YWHAG

Alternative Splicing Database (ASD) splice patterns (SP) for YWHAG Gene

No ASD Table

Relevant External Links for YWHAG Gene

GeneLoc Exon Structure for
YWHAG
ECgene alternative splicing isoforms for
YWHAG

Expression for YWHAG Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for YWHAG Gene

mRNA differential expression in normal tissues according to GTEx for YWHAG Gene

This gene is overexpressed in Brain - Frontal Cortex (BA9) (x4.6) and Brain - Anterior cingulate cortex (BA24) (x4.1).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for YWHAG Gene



Protein tissue co-expression partners for YWHAG Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of YWHAG Gene:

YWHAG

SOURCE GeneReport for Unigene cluster for YWHAG Gene:

Hs.744840

mRNA Expression by UniProt/SwissProt for YWHAG Gene:

P61981-1433G_HUMAN
Tissue specificity: Highly expressed in brain, skeletal muscle, and heart.

Evidence on tissue expression from TISSUES for YWHAG Gene

  • Nervous system(5)
  • Muscle(4.6)
  • Blood(4.4)
  • Liver(4.4)
  • Heart(2.5)
  • Intestine(2.3)
  • Spleen(2)
genes like me logo Genes that share expression patterns with YWHAG: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , Protein differential expression in normal tissues and Phenotype-based relationships between genes and organs from Gene ORGANizer for YWHAG Gene

Orthologs for YWHAG Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for YWHAG Gene

Organism Taxonomy Gene Similarity Type Details
oppossum
(Monodelphis domestica)
Mammalia YWHAG 34
  • 100 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia YWHAG 33 34
  • 99.73 (n)
cow
(Bos Taurus)
Mammalia YWHAG 33 34
  • 93.25 (n)
mouse
(Mus musculus)
Mammalia Ywhag 33 16 34
  • 92.44 (n)
rat
(Rattus norvegicus)
Mammalia Ywhag 33
  • 92.17 (n)
dog
(Canis familiaris)
Mammalia YWHAG 33 34
  • 90.28 (n)
chicken
(Gallus gallus)
Aves YWHAG 33 34
  • 89.88 (n)
lizard
(Anolis carolinensis)
Reptilia YWHAG 34
  • 100 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia ywhag 33
  • 81.92 (n)
African clawed frog
(Xenopus laevis)
Amphibia MGC69099 33
zebrafish
(Danio rerio)
Actinopterygii ywhag1 34
  • 96 (a)
OneToMany
ywhag2 34
  • 96 (a)
OneToMany
ywhag 33
fruit fly
(Drosophila melanogaster)
Insecta 14-3-3zgr 35
  • 75 (a)
worm
(Caenorhabditis elegans)
Secernentea M117.3 34
  • 40 (a)
OneToMany
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes BMH1 34
  • 56 (a)
ManyToMany
BMH2 34
  • 55 (a)
ManyToMany
sea squirt
(Ciona savignyi)
Ascidiacea -- 34
  • 61 (a)
ManyToMany
CSA.10834 34
  • 60 (a)
ManyToMany
CSA.10888 34
  • 53 (a)
ManyToMany
-- 34
  • 51 (a)
ManyToMany
CSA.11325 34
  • 51 (a)
ManyToMany
-- 34
  • 47 (a)
ManyToMany
Species where no ortholog for YWHAG was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for YWHAG Gene

ENSEMBL:
Gene Tree for YWHAG (if available)
TreeFam:
Gene Tree for YWHAG (if available)

Paralogs for YWHAG Gene

Paralogs for YWHAG Gene

(9) SIMAP similar genes for YWHAG Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with YWHAG: view

Variants for YWHAG Gene

Sequence variations from dbSNP and Humsavar for YWHAG Gene

SNP ID Clin Chr 07 pos Sequence Context AA Info Type
rs1000142507 -- 76,358,427(+) CCTAG(A/T)GCCGC intron-variant
rs1000222353 -- 76,351,200(+) AGTCA(A/G)TCCCA intron-variant
rs1000332025 -- 76,327,336(+) CAACA(C/T)TAGCA utr-variant-3-prime
rs1000413621 -- 76,343,407(+) CTTCT(C/T)CACAT intron-variant
rs1000419932 -- 76,348,951(+) TGTTG(C/T)GAAAT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for YWHAG Gene

Variant ID Type Subtype PubMed ID
nsv528969 CNV gain 19592680
nsv428174 CNV gain 18775914
nsv1148733 CNV deletion 26484159
nsv1143414 CNV deletion 24896259
nsv1028665 CNV gain 25217958
esv2678206 CNV deletion 23128226
esv2422494 CNV duplication 17116639
dgv120n16 CNV deletion 17901297

Variation tolerance for YWHAG Gene

Residual Variation Intolerance Score: 24% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.14; 3.16% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for YWHAG Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
YWHAG

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for YWHAG Gene

Disorders for YWHAG Gene

MalaCards: The human disease database

(1) MalaCards diseases for YWHAG Gene - From: DISEASES and GeneCards

Disorder Aliases PubMed IDs
creutzfeldt-jakob disease
  • creutzfeldt-jakob disease, variant
- elite association - COSMIC cancer census association via MalaCards
Search YWHAG in MalaCards View complete list of genes associated with diseases

Relevant External Links for YWHAG

Genetic Association Database (GAD)
YWHAG
Human Genome Epidemiology (HuGE) Navigator
YWHAG
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
YWHAG
genes like me logo Genes that share disorders with YWHAG: view

No data available for UniProtKB/Swiss-Prot and Genatlas for YWHAG Gene

Publications for YWHAG Gene

  1. Cloning, expression, and chromosomal mapping of the human 14-3-3gamma gene (YWHAG) to 7q11.23. (PMID: 10486217) Horie M … Tanigami A (Genomics 1999) 2 3 4 22 60
  2. 14-3-3Gamma interacts with and is phosphorylated by multiple protein kinase C isoforms in PDGF-stimulated human vascular smooth muscle cells. (PMID: 10433554) Autieri MV … Carbone CJ (DNA and cell biology 1999) 2 3 4 60
  3. ACBD3 interaction with TBC1 domain 22 protein is differentially affected by enteroviral and kobuviral 3A protein binding. (PMID: 23572552) Greninger AL … DeRisi JL (mBio 2013) 3 4 60
  4. Centrosome-related genes, genetic variation, and risk of breast cancer. (PMID: 20508983) Olson JE … Couch FJ (Breast cancer research and treatment 2011) 3 45 60
  5. Genome-wide association study of severity in multiple sclerosis. (PMID: 21654844) International Multiple Sclerosis Genetics Consortium (Genes and immunity 2011) 3 45 60

Products for YWHAG Gene

  • Addgene plasmids for YWHAG

Sources for YWHAG Gene

Content
Loading form....