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YWHAG Gene

protein-coding   GIFtS: 65
GCID: GC07M075956

Tyrosine 3-Monooxygenase/Tryptophan 5-Monooxygenase Activation...

(Previous names: tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation...)
Microbiology & Infectious Diseases Congress
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(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Tyrosine 3-Monooxygenase/Tryptophan 5-Monooxygenase Activation Protein,
Gamma1 2
     KCIP-12 3
Tyrosine 3-Monooxygenase/Tryptophan 5-Monooxygenase Activation Protein,
Gamma Polypeptide1 2
     14-3-3 Protein Gamma2
14-3-3 Gamma1 2     14-3-3GAMMA2
Protein Kinase C Inhibitor Protein 12 3     

External Ids:    HGNC: 128521   Entrez Gene: 75322   Ensembl: ENSG000001700277   OMIM: 6053565   UniProtKB: P619813   

Export aliases for YWHAG gene to outside databases

Previous GC identifers: GC07M074491 GC07M075554 GC07M075568 GC07M075600 GC07M075794 GC07M071042


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for YWHAG Gene:
This gene product belongs to the 14-3-3 family of proteins which mediate signal transduction by binding to
phosphoserine-containing proteins. This highly conserved protein family is found in both plants and mammals, and
this protein is 100% identical to the rat ortholog. It is induced by growth factors in human vascular smooth
muscle cells, and is also highly expressed in skeletal and heart muscles, suggesting an important role for this
protein in muscle tissue. It has been shown to interact with RAF1 and protein kinase C, proteins involved in
various signal transduction pathways. (provided by RefSeq, Jul 2008)

GeneCards Summary for YWHAG Gene:
YWHAG (tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, gamma) is a protein-coding gene. Diseases associated with YWHAG include bacterial meningitis, and meningitis. GO annotations related to this gene include receptor tyrosine kinase binding and protein domain specific binding. An important paralog of this gene is YWHAH.

UniProtKB/Swiss-Prot: 1433G_HUMAN, P61981
Function: Adapter protein implicated in the regulation of a large spectrum of both general and specialized
signaling pathways. Binds to a large number of partners, usually by recognition of a phosphoserine or
phosphothreonine motif. Binding generally results in the modulation of the activity of the binding partner

summary for YWHAG Gene:
14.3.3 proteins are a group of highly conserved proteins that are involved in many vital cellular processes
such as metabolism, protein trafficking, signal transduction, apoptosis and cell cycle regulation. 14.3.3
proteins are phospho-serine/phospho-threonine binding proteins that have a diverse array of partners
including transcription factors, biosynthetic enzymes, cytoskeletal proteins, signalling molecules,
apoptosis factors and tumour suppressors. The 14.3.3 family consists of 7 isoforms; beta, gamma, epsilon,
sigma, zeta, tau and eta. 14.3.3 proteins are ubiquitously expressed and self assemble into homo- and
heterodimers, with the exception of 14.3.3sigma, which exclusively forms homodimers and is found in cells of
epithelial origin only. Each monomer contains an independent ligand-binding site, thus the 14.3.3 dimer can
interact with two target proteins simultaneously. 14.3.3 proteins are highly rigid structures and ligand
binding can induce conformational changes that alter the stability and/or catalytic activity of the ligand.
Furthermore, 14.3.3 protein binding can physically occlude sequence-specific or structural motifs on the
target that prevent molecular interactions and/or modulate the accessibility of a target protein to
modifying enzymes such as kinases, phosphatases and proteases. In addition, 14.3.3 proteins can act as a
scaffold molecule to anchor target proteins within close proximity of one another. 14.3.3 proteins represent
an integration point for proliferative, survival, apoptotic and stress signalling pathways. Members of the
14.3.3 protein family enhance the activity of many proteins with proliferative and/or survival functions,
such as Raf kinases, and antagonise the activity of proteins that promote cell death and senescence, such as
Bad, Bim and Bax. In contrast, 14.3.3sigma acts as a tumour suppressor and its expression is upregulated
coordinately with p53 and BRAC1. This isoform sequesters cdk1-cyclin B complexes in the cytoplasm, and thus
delays cell cycle progression. 14.3.3sigma is also a crucial regulator of translation during mitosis.
Because many 14.3.3 interactions are phosphorylation dependent, 14.3.3 proteins have been integrated into
the core regulatory pathways that are crucial for normal growth and development. 14.3.3 proteins are
directly involved in cellular processes such as cytokinesis, cell-contact inhibition, anchorage-independent
growth and cell adhesion, and it is these pathways that often become dysregulated in disease states such as
cancer.

Gene Wiki entry for YWHAG Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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Regulatory elements:
   Regulatory transcription factor binding sites in the YWHAG gene promoter:
         c-Fos   NF-1   NF-1/L   AP-1   FosB   YY1   CREB   deltaCREB   c-Jun   Pax-4a   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 6): YWHAG promoter sequence
   Search Chromatin IP Primers for YWHAG

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat YWHAG


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 7q11.23   Ensembl cytogenetic band:  7q11.23   HGNC cytogenetic band: 7q11.23

YWHAG Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
YWHAG gene location

GeneLoc information about chromosome 7         GeneLoc Exon Structure

GeneLoc location for GC07M075956:  view genomic region     (about GC identifiers)

Start:
75,956,108 bp from pter      End:
75,988,348 bp from pter
Size:
32,241 bases      Orientation:
minus strand

1 alternative location:
Chr7-,CRA_TCAG 75,289,172-75,321,406     

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
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UniProtKB/Swiss-Prot: 1433G_HUMAN, P61981 (See protein sequence)
Recommended Name: 14-3-3 protein gamma  
Size: 247 amino acids; 28303 Da
Subunit: Homodimer. Interacts with SAMSN1 (By similarity). Interacts with RAF1, SSH1 and CRTC2/TORC2. Interacts
with ABL1 (phosphorylated form); the interaction retains it in the cytoplasm. Interacts with GAB2. Interacts with
MDM4 (phosphorylated); negatively regulates MDM4 activity toward TP53. Interacts with PKA-phosphorylated AANAT
4 PDB 3D structures from and Proteopedia for YWHAG:
2B05 (3D)        3UZD (3D)        4E2E (3D)        4J6S (3D)    
Secondary accessions: O70457 P35214 Q6FH52 Q9UDP2 Q9UN99

Explore the universe of human proteins at neXtProt for YWHAG: NX_P61981

Explore proteomics data for YWHAG at MOPED

Post-translational modifications: 

  • Phosphorylated by various PKC isozymes1
  • Ubiquitination2 at Lys10, Lys50, Lys125, Lys127, Lys142
  • Modification sites at PhosphoSitePlus

  • See YWHAG Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_036611.2  
    ENSEMBL proteins: 
     ENSP00000306330  
    Reactome Protein details: P61981

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    Browse Proteins at Cloud-Clone Corp.

    YWHAG Antibody Products:

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    YWHAG Assay Products:

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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    3 InterPro protein domains:
     IPR023409 14-3-3_CS
     IPR023410 14-3-3_domain
     IPR000308 14-3-3

    Graphical View of Domain Structure for InterPro Entry P61981

    ProtoNet protein and cluster: P61981

    1 Blocks protein domain: IPB000308 14-3-3 protein

    UniProtKB/Swiss-Prot: 1433G_HUMAN, P61981
    Similarity: Belongs to the 14-3-3 family


    YWHAG for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
    About This Section

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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: 1433G_HUMAN, P61981
    Function: Adapter protein implicated in the regulation of a large spectrum of both general and specialized
    signaling pathways. Binds to a large number of partners, usually by recognition of a phosphoserine or
    phosphothreonine motif. Binding generally results in the modulation of the activity of the binding partner

         Genatlas biochemistry entry for YWHAG:
    tyrosine 3-monooxygenase/trytophan 5 monooxygenase activation protein,14-3-3 G, highly expressed in brain,skeletal
    muscles,heat,located telomeric to D7S1870 at the most telomeric end of the common deletion of
    WBS1,multifunctional regulator involved in cell-cyle control (checkpoint) and signal transduction,inhibitor of
    apoptosis through inhibiting the activation of p38 MAP kinase

         Gene Ontology (GO): Selected molecular function terms (see all 7):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005080protein kinase C binding IPI10433554
    GO:0005159insulin-like growth factor receptor binding IPI12482592
    GO:0005515protein binding IPI11237865
    GO:0008426protein kinase C inhibitor activity NAS10433554
    GO:0019904protein domain specific binding IEA--
         
    YWHAG for ontologies           About GeneDecksing


    Phenotypes:
         1 GenomeRNAi human phenotype for YWHAG:
     Decreased homologous recombina 

         1 MGI mutant phenotype (inferred from 1 allele(MGI details for Ywhag):
     normal 

    YWHAG for phenotypes           About GeneDecksing

    Animal Models:
         MGI mouse knock-out Ywhagtm1Otto for YWHAG

       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for YWHAG
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       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for YWHAG

    miRNA
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    miRTarBase miRNAs that target YWHAG:
    hsa-let-7e-5p (MIRT051462), hsa-mir-141-3p (MIRT006730), hsa-mir-96-5p (MIRT027922), hsa-mir-222-3p (MIRT046644), hsa-mir-132-5p (MIRT038650)

    Block miRNA regulation of human, mouse, rat YWHAG using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate YWHAG (see all 65):
    hsa-miR-3607-3p hsa-miR-200a hsa-miR-519a hsa-miR-1243 hsa-miR-200b hsa-miR-3148 hsa-miR-4273 hsa-miR-509-3-5p
    SwitchGear 3'UTR luciferase reporter plasmidYWHAG 3' UTR sequence
    Inhib. RNA
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    Predesigned siRNA for gene silencing in human, mouse, rat YWHAG

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    GenScript: all cDNA clones in your preferred vector: YWHAG (NM_012479)
    Sino Biological Human cDNA Clone for YWHAG
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for YWHAG
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat YWHAG

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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for YWHAG


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    1433G_HUMAN, P61981: Cytoplasm (By similarity)
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    cytosol4
    nucleus2
    cytoskeleton1

    Gene Ontology (GO): 4 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005829cytosol TAS--
    GO:0030659cytoplasmic vesicle membrane TAS--
    GO:0031988membrane-bounded vesicle ----
    GO:0070062extracellular vesicular exosome IDA19056867

    YWHAG for ontologies           About GeneDecksing


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for YWHAG About   (see all 49)                                                                                              See pathways by source

    SuperPathContained pathways About
    1Cell cycle
    Cell cycle0.59
    Cell cycle0.59
    2Cell cycle Role of 14 3 3 proteins in cell cycle regulation
    Cell cycle Role of 14 3 3 proteins in cell cycle regulation0.45
    14-3-3 and Cell Cycle Regulation0.45
    3Development Dopamine D2 receptor transactivation of EGFR
    Apoptosis and survival BAD phosphorylation0.41
    BAD Phosphorylation0.41
    4Regulation of PLK1 Activity at G2/M Transition
    Recruitment of mitotic centrosome proteins and complexes0.86
    Regulation of PLK1 Activity at G2/M Transition0.77
    Loss of Nlp from mitotic centrosomes0.86
    G2/M Transition0.70
    Centrosome maturation0.86
    Mitotic G2-G2/M phases0.69
    Loss of proteins required for interphase microtubule organizationfrom the centrosome0.86
    5Activation of cAMP-Dependent PKA
    Activation of cAMP-Dependent PKA0.77
    Activation of PKA through GPCR0.71
    cAMP Pathway0.77
    PKA Signaling0.56

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    1 R&D Systems Pathway for YWHAG
        Apoptosis Signaling Pathways

    Selected Downloadable PowerPoint Slides of GeneGlobe Pathway Central Maps for YWHAG (see all 19)
        14-3-3 Induced Apoptosis
    DHA Signaling
    PKA Signaling
    ERK5 Signaling
    BDNF Pathway

    3 Cell Signaling Technology (CST) Pathways for YWHAG
        Apoptosis and Autophagy
    Cell Cycle / Checkpoint Control
    Tyrosine Kinases / Adaptors

    2 Tocris Bioscience Pathways for YWHAG
        Insulin Pathway
    Apoptosis Pathway

    5 GeneGo (Thomson Reuters) Pathways for YWHAG
        Apoptosis and survival BAD phosphorylation
    Cytoskeleton remodeling Keratin filaments
    Development Role of HDAC and calcium/calmodulin-dependent kinase (CaMK) in control of skeletal myogenesis
    Immune response Function of MEF2 in T lymphocytes
    Cell cycle Role of 14-3-3 proteins in cell cycle regulation

    Selected BioSystems Pathways for YWHAG (see all 17)
        Myometrial Relaxation and Contraction Pathways
    Cell cycle
    SIDS Susceptibility Pathways
    Calcium Regulation in the Cardiac Cell
    TNF-alpha/NF-kB Signaling Pathway


    Selected Reactome Pathways for YWHAG (see all 6)
        Activation of BAD and translocation to mitochondria
    Translocation of GLUT4 to the plasma membrane
    Recruitment of mitotic centrosome proteins and complexes
    Loss of proteins required for interphase microtubule organization,from the centrosome
    Regulation of PLK1 Activity at G2/M Transition


    Selected Kegg Pathways  (Kegg details for YWHAG) (see all 6):
        Cell cycle
    Oocyte meiosis
    PI3K-Akt signaling pathway
    Hippo signaling pathway
    Epstein-Barr virus infection


    YWHAG for pathways           About GeneDecksing

        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for YWHAG
    Interactions:

        GeneGlobe Interaction Network for YWHAG

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for YWHAG (P619811, 2, 3 ENSP000003063304) via UniProtKB, MINT, STRING, and/or I2D (see all 880)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    MDM4O151511, 2, 3, ENSP000003561504EBI-359832,EBI-398437 MINT-1957780 MINT-1958362 MINT-1958118 MINT-1958145 MINT-1958602 MINT-1957996 MINT-1958083 I2D: score=4 STRING: ENSP00000356150
    TP53P046371, 2, 3, ENSP000002693054EBI-359832,EBI-366083 MINT-8008679 MINT-8009392 MINT-8008658 MINT-8009385 MINT-8415355 MINT-8008651 MINT-8009378 I2D: score=2 STRING: ENSP00000269305
    HSPA1AP081072, 3, ENSP000003648024MINT-50819 I2D: score=3 STRING: ENSP00000364802
    ENSG00000232575P074372, 3, ENSP000004100714MINT-50383 MINT-50849 MINT-8415355 I2D: score=2 STRING: ENSP00000410071
    ENSG00000212866P081072, 3MINT-50819 I2D: score=3 
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 13):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000086G2/M transition of mitotic cell cycle TAS--
    GO:0000278mitotic cell cycle TAS--
    GO:0006469negative regulation of protein kinase activity NAS10433554
    GO:0006605protein targeting IEA--
    GO:0006915apoptotic process TAS--

    YWHAG for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
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    Compounds for YWHAG available from Tocris Bioscience    About this table
    CompoundAction CAS #
    DifopeinHigh affinity inhibitor of 14.3.3 proteins; induces apoptosis[396834-58-5]
    R18Inhibitor of 14.3.3 proteins; induces apoptosis[211364-78-2]

    2 HMDB Compounds for YWHAG    About this table
    CompoundSynonyms CAS #PubMed Ids
    SepiapterinL-sepiapterin (see all 8)17094-01-8--
    ZolpidemAmbien (see all 7)82626-48-0--



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
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    REFSEQ mRNAs for YWHAG gene: 
    NM_012479.3  

    1 Ensembl transcript including schematic representation, and UCSC links where relevant:
    ENST00000307630(uc011kgj.1)
    Congresses - knowledge worth sharing:
    European Congress of Clinical Microbiology and Infectious Diseases (ECCMID) 10 - 13 May 2014

    miRNA
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    Selected qRT-PCR Assays for microRNAs that regulate YWHAG (see all 65):
    hsa-miR-3607-3p hsa-miR-200a hsa-miR-519a hsa-miR-1243 hsa-miR-200b hsa-miR-3148 hsa-miR-4273 hsa-miR-509-3-5p
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      QuantiTect SYBR Green Assays in human, mouse, rat YWHAG
      QuantiFast Probe-based Assays in human, mouse, rat YWHAG

    Selected AceView cDNA sequences (see all 451):

    AI978599 BX386823 AI950933 D57439 BM801917 AA137224 BU190149 CB044902 
    BF515338 BG705074 AA604572 AW847690 BM455143 BU192168 BQ937755 BU521081 
    AA983660 AL537903 BU634095 BM469294 AI684319 AA629231 BP340024 AA652212 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    YWHAG expression in normal human tissues (normalized intensities)      YWHAG embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: AATGTGAGTC
    YWHAG Expression
    About this image


    YWHAG expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 14) fully expand
     
     Brain (Nervous System)    fully expand to see all 9 entries
             Cerebral Cortex
     
     Neural Tube (Nervous System)    fully expand to see all 3 entries
             Metencephalon
     
     Ovary (Reproductive System)    fully expand to see all 2 entries
             Ovarian Mesenchymal Stroma Cells Ovary Interstitium
             Oviduct
     
     Gut Tube (Gastrointestinal Tract)
             Foregut
     
     Bone (Muscoskeletal System)
             Bone Marrow
    YWHAG Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    YWHAG Protein Expression

    UniProtKB/Swiss-Prot: 1433G_HUMAN, P61981
    Tissue specificity: Highly expressed in brain, skeletal muscle, and heart

        Custom PCR Arrays for YWHAG
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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of animals and fungi.

    Orthologs for YWHAG gene from Selected species (see all 16)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Ywhag1 , 5 tyrosine 3-monooxygenase/tryptophan 5-monooxygenase more1, 5 92.44(n)1
    100(a)1
      5 (75.53 cM)5
    226281  NM_018871.31  NP_061359.21 
     1359084095 
    chicken
    (Gallus gallus)
    Aves YWHAG1 tyrosine 3-monooxygenase/tryptophan 5-monooxygenase more 89.88(n)
    99.6(a)
      427820  NM_001031477.1  NP_001026648.1 
    lizard
    (Anolis carolinensis)
    Reptilia YWHAG6
    tyrosine 3-monooxygenase/tryptophan 5-monooxygenas...
    100(a)
    1 ↔ 1
    GL344496.1(4550-5206)
    African clawed frog
    (Xenopus laevis)
    Amphibia MGC690992 hypothetical protein MGC69099 80.97(n)    BC059340.1 
    zebrafish
    (Danio rerio)
    Actinopterygii ywhag2 Danio rerio cDNA clone MGC73131 IMAGE4789932, complete more 83.66(n)    BC059494.1 
    worm
    (Caenorhabditis elegans)
    Secernentea M117.36
    Protein M117.3 (M117.3) mRNA, complete cds
    40(a)
    1 → many
    IV(11823371-11823938) WBGene00010919
    baker's yeast
    (Saccharomyces cerevisiae)
    Saccharomycetes BMH16
    BMH26
    14-3-3 protein, major isoform; controls proteome a...
    14-3-3 protein, minor isoform; controls proteome a...
    56(a)
    55(a)
    many ↔ many
    many ↔ many
    V(545611-546414) YER177W
    IV(653607-654428) YDR099W


    ENSEMBL Gene Tree for YWHAG (if available)
    TreeFam Gene Tree for YWHAG (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for YWHAG gene
    YWHAH2  YWHAE2  YWHAB2  YWHAQ2  SFN2  YWHAZ2  
    9 SIMAP similar genes for YWHAG using alignment to 1 protein entry:     1433G_HUMAN:
    YWHAH    YWHAB    YWHAZ    SFN    14-3-3 protein    YWHAQ
    YWHAE    YWHAE/FAM22A fusion    YWHAE/FAM22B fusion

    YWHAG for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for YWHAG (see all 769)    About this table    
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 7 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1838530531,2
    --75955697(+) ACCTCC/TACCTC 1 -- ds50010--------
    rs1158796671,2
    C,F--75955755(+) TACAGA/GCACCC 1 -- ds50011Minor allele frequency- G:0.14WA 118
    rs1883463851,2
    --75955793(+) TTTTAA/GTAGAG 1 -- ds50010--------
    rs1446807431,2
    C--75955856(+) ATCCGC/TCCGCC 1 -- ds50010--------
    rs1131443011,2
    F--75955966(+) GGAGGC/TGCTTT 1 -- ds50011Minor allele frequency- T:0.50CSA 2
    rs1138692191,2
    C--75956114(+) ACTGGC/TGTCAG 1 -- ut310--------
    rs1137793571,2
    C--75956115(+) CTGGCG/TTCAGA 1 -- ut310--------
    rs1417716251,2
    C--75956146(+) ATGTAC/TGACAG 1 -- ut310--------
    rs1157370351,2
    C,F--75956327(+) GAACAT/CATTTG 1 -- ut311Minor allele frequency- C:0.02WA 118
    rs1996337391,2
    --75956997(+) CCCCC-/CTCCCCC 1 -- ut310--------

    HapMap Linkage Disequilibrium report for YWHAG (75956108 - 75988348 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 8 variations for YWHAG:    About this table    
    Variant IDTypeSubtypePubMed ID
    dgv120n16CNV Deletion17901297
    esv2678206CNV Deletion23128226
    esv2422494CNV Duplication17116639
    nsv888387CNV Loss21882294
    nsv428174CNV Gain18775914
    nsv528969CNV Gain19592680
    essv14753CNV CNV17122850
    dgv2104e1CNV Complex17122850

    Site Specific Mutation Identification with PCR Assays
    Search QIAGEN SeqTarget long-range PCR primers for resequencing YWHAG
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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 605356    OMIM disorders: --

    20 diseases for YWHAG:    About MalaCards
    bacterial meningitis    meningitis    lipodystrophy    williams-beuren syndrome
    intellectual disability    leiomyoma    rhabdomyosarcoma    down syndrome
    insulin resistance    meningioma    multiple sclerosis    schizophrenia
    parkinson's disease    hypoxia    hepatocellular carcinoma    lung cancer
    breast cancer    hiv-1    cerebritis    neuronitis


    YWHAG for disorders           About GeneDecksing


    Congresses - knowledge worth sharing:
    Alzheimer's & Parkinson's Diseases Congress (ADPD) 18 - 22 March 2015
    Genetic Association Database (GAD): YWHAG
    Human Genome Epidemiology (HuGE) Navigator: YWHAG (1 document)

    Export disorders for YWHAG gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for YWHAG gene, integrated from 10 sources (see all 170):
    (articles sorted by number of sources associating them with YWHAG)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Cloning, expression, and chromosomal mapping of the human 14-3-3gamma gene (YWHAG) to 7q11.23. (PubMed id 10486217)1, 2, 3, 9 Horie M.... Tanigami A. (Genomics 1999)
    2. 14-3-3gamma interacts with and is phosphorylated by multiple protein kinase C isoforms in PDGF-stimulated human vascular smooth muscle cells. (PubMed id 10433554)1, 2, 3 Autieri M.V. and Carbone C.J. (DNA Cell Biol. 1999)
    3. Centrosome-related genes, genetic variation, and risk of breast cancer. (PubMed id 20508983)1, 4 Olson J.E....Couch F.J. (Breast Cancer Res. Treat. 2011)
    4. Genome-wide association study of severity in multiple sclerosis. (PubMed id 21654844)1, 4 (Genes Immun. 2011)
    5. Phosphorylation-dependent binding of 14-3-3 terminates signalling by the Gab2 docking protein. (PubMed id 19172738)1, 2 Brummer T.... Daly R.J. (EMBO J. 2008)
    6. 14-3-3gamma binds to MDMX that is phosphorylated by UV-activated Chk1, resulting in p53 activation. (PubMed id 16511572)1, 2 Jin Y.... Lu H. (EMBO J. 2006)
    7. JNK phosphorylation of 14-3-3 proteins regulates nuclear targeting of c-Abl in the apoptotic response to DNA damage. (PubMed id 15696159)1, 2 Yoshida K.... Miki Y. (Nat. Cell Biol. 2005)
    8. A pathway of neuregulin-induced activation of cofilin-phosphatase Slingshot and cofilin in lamellipodia. (PubMed id 15159416)1, 2 Nagata-Ohashi K.... Mizuno K. (J. Cell Biol. 2004)
    9. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    10. Exploring proteomes and analyzing protein processing by mass spectrometric identification of sorted N-terminal peptides. (PubMed id 12665801)1, 2 Gevaert K.... Vandekerckhove J. (Nat. Biotechnol. 2003)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 7532 HGNC: 12852 AceView: YWHAG Ensembl:ENSG00000170027 euGenes: HUgn7532
    ECgene: YWHAG Kegg: 7532 H-InvDB: YWHAG

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for YWHAG Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for YWHAG gene:
    Search GeneIP for patents involving YWHAG

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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