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Aliases for YWHAG Gene

Aliases for YWHAG Gene

  • Tyrosine 3-Monooxygenase/Tryptophan 5-Monooxygenase Activation Protein, Gamma 2 3
  • Tyrosine 3-Monooxygenase/Tryptophan 5-Monooxygenase Activation Protein, Gamma Polypeptide 2 3
  • Protein Kinase C Inhibitor Protein 1 3 4
  • 14-3-3 Gamma 2 3
  • KCIP-1 3 4
  • Protein Phosphatase 1, Regulatory Subunit 170 3
  • Regulatory Subunit 170 2
  • Protein Phosphatase 1 2
  • 14-3-3 Protein Gamma 3
  • 14-3-3GAMMA 3
  • PPP1R170 3

External Ids for YWHAG Gene

Previous GeneCards Identifiers for YWHAG Gene

  • GC07M074491
  • GC07M075554
  • GC07M075568
  • GC07M075600
  • GC07M075794
  • GC07M075956
  • GC07M071042

Summaries for YWHAG Gene

Entrez Gene Summary for YWHAG Gene

  • This gene product belongs to the 14-3-3 family of proteins which mediate signal transduction by binding to phosphoserine-containing proteins. This highly conserved protein family is found in both plants and mammals, and this protein is 100% identical to the rat ortholog. It is induced by growth factors in human vascular smooth muscle cells, and is also highly expressed in skeletal and heart muscles, suggesting an important role for this protein in muscle tissue. It has been shown to interact with RAF1 and protein kinase C, proteins involved in various signal transduction pathways. [provided by RefSeq, Jul 2008]

GeneCards Summary for YWHAG Gene

YWHAG (Tyrosine 3-Monooxygenase/Tryptophan 5-Monooxygenase Activation Protein, Gamma) is a Protein Coding gene. Among its related pathways are PI3K-Akt signaling pathway and Akt Signaling. GO annotations related to this gene include protein domain specific binding and receptor tyrosine kinase binding. An important paralog of this gene is YWHAZ.

UniProtKB/Swiss-Prot for YWHAG Gene

  • Adapter protein implicated in the regulation of a large spectrum of both general and specialized signaling pathways. Binds to a large number of partners, usually by recognition of a phosphoserine or phosphothreonine motif. Binding generally results in the modulation of the activity of the binding partner.

Tocris Summary for YWHAG Gene

  • 14.3.3 proteins are a group of highly conserved proteins that are involved in many vital cellular processes such as metabolism, protein trafficking, signal transduction, apoptosis and cell cycle regulation. 14.3.3 proteins are phospho-serine/phospho-threonine binding proteins that have a diverse array of partners including transcription factors, biosynthetic enzymes, cytoskeletal proteins, signalling molecules, apoptosis factors and tumour suppressors. The 14.3.3 family consists of 7 isoforms; beta, gamma, epsilon, sigma, zeta, tau and eta. 14.3.3 proteins are ubiquitously expressed and self assemble into homo- and heterodimers, with the exception of 14.3.3sigma, which exclusively forms homodimers and is found in cells of epithelial origin only. Each monomer contains an independent ligand-binding site, thus the 14.3.3 dimer can interact with two target proteins simultaneously. 14.3.3 proteins are highly rigid structures and ligand binding can induce conformational changes that alter the stability and/or catalytic activity of the ligand. Furthermore, 14.3.3 protein binding can physically occlude sequence-specific or structural motifs on the target that prevent molecular interactions and/or modulate the accessibility of a target protein to modifying enzymes such as kinases, phosphatases and proteases. In addition, 14.3.3 proteins can act as a scaffold molecule to anchor target proteins within close proximity of one another. 14.3.3 proteins represent an integration point for proliferative, survival, apoptotic and stress signalling pathways. Members of the 14.3.3 protein family enhance the activity of many proteins with proliferative and/or survival functions, such as Raf kinases, and antagonise the activity of proteins that promote cell death and senescence, such as Bad, Bim and Bax. In contrast, 14.3.3sigma acts as a tumour suppressor and its expression is upregulated coordinately with p53 and BRAC1. This isoform sequesters cdk1-cyclin B complexes in the cytoplasm, and thus delays cell cycle progression. 14.3.3sigma is also a crucial regulator of translation during mitosis. Because many 14.3.3 interactions are phosphorylation dependent, 14.3.3 proteins have been integrated into the core regulatory pathways that are crucial for normal growth and development. 14.3.3 proteins are directly involved in cellular processes such as cytokinesis, cell-contact inhibition, anchorage-independent growth and cell adhesion, and it is these pathways that often become dysregulated in disease states such as cancer.

Gene Wiki entry for YWHAG Gene

No data available for PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for YWHAG Gene

Genomics for YWHAG Gene

Regulatory Elements for YWHAG Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for YWHAG Gene

76,326,791 bp from pter
76,359,031 bp from pter
32,241 bases
Minus strand

Genomic View for YWHAG Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for YWHAG Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for YWHAG Gene

Proteins for YWHAG Gene

  • Protein details for YWHAG Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    14-3-3 protein gamma
    Protein Accession:
    Secondary Accessions:
    • O70457
    • P35214
    • Q6FH52
    • Q9UDP2
    • Q9UN99

    Protein attributes for YWHAG Gene

    247 amino acids
    Molecular mass:
    28303 Da
    Quaternary structure:
    • Homodimer. Interacts with SAMSN1 (By similarity). Interacts with RAF1, SSH1 and CRTC2/TORC2. Interacts with ABL1 (phosphorylated form); the interaction retains it in the cytoplasm. Interacts with GAB2. Interacts with MDM4 (phosphorylated); negatively regulates MDM4 activity toward TP53. Interacts with PKA-phosphorylated AANAT and SIRT2.

    Three dimensional structures from OCA and Proteopedia for YWHAG Gene

neXtProt entry for YWHAG Gene

Proteomics data for YWHAG Gene at MOPED

Post-translational modifications for YWHAG Gene

  • Phosphorylated by various PKC isozymes.
  • Ubiquitination at Lys10, Lys50, Lys125, Lys127, and Lys142
  • Modification sites at PhosphoSitePlus

Other Protein References for YWHAG Gene

ENSEMBL proteins:
Reactome Protein details:
REFSEQ proteins:

Antibody Products

  • Cell Signaling Technology (CST) Antibodies for YWHAG (14-3-3 gamma)

No data available for DME Specific Peptides for YWHAG Gene

Domains for YWHAG Gene

Protein Domains for YWHAG Gene


Graphical View of Domain Structure for InterPro Entry



1433G_HUMAN :
  • P61981
  • Belongs to the 14-3-3 family.
genes like me logo Genes that share domains with YWHAG: view

No data available for Gene Families for YWHAG Gene

Function for YWHAG Gene

Molecular function for YWHAG Gene

GENATLAS Biochemistry:
tyrosine 3-monooxygenase/trytophan 5 monooxygenase activation protein,14-3-3 G, highly expressed in brain,skeletal muscles,heat,located telomeric to D7S1870 at the most telomeric end of the common deletion of WBS1,multifunctional regulator involved in cell-cyle control (checkpoint) and signal transduction,inhibitor of apoptosis through inhibiting the activation of p38 MAP kinase
UniProtKB/Swiss-Prot Function:
Adapter protein implicated in the regulation of a large spectrum of both general and specialized signaling pathways. Binds to a large number of partners, usually by recognition of a phosphoserine or phosphothreonine motif. Binding generally results in the modulation of the activity of the binding partner.

Gene Ontology (GO) - Molecular Function for YWHAG Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005080 protein kinase C binding IPI 10433554
GO:0005159 insulin-like growth factor receptor binding IPI 12482592
GO:0005515 protein binding IPI 11237865
GO:0008426 protein kinase C inhibitor activity NAS 10433554
GO:0019904 protein domain specific binding IEA --
genes like me logo Genes that share ontologies with YWHAG: view

Phenotypes for YWHAG Gene

MGI mutant phenotypes for YWHAG:
inferred from 1 alleles
GenomeRNAi human phenotypes for YWHAG:
genes like me logo Genes that share phenotypes with YWHAG: view

Animal Models for YWHAG Gene

MGI Knock Outs for YWHAG:

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for YWHAG

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Transcription Factor Targeting and HOMER Transcription for YWHAG Gene

Localization for YWHAG Gene

Subcellular locations from UniProtKB/Swiss-Prot for YWHAG Gene


Subcellular locations from

Jensen Localization Image for YWHAG Gene COMPARTMENTS Subcellular localization image for YWHAG gene
Compartment Confidence
cytosol 4
nucleus 2
cytoskeleton 1

Gene Ontology (GO) - Cellular Components for YWHAG Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005829 cytosol TAS --
GO:0005925 focal adhesion IDA 21423176
GO:0016020 membrane IDA 19946888
GO:0030659 cytoplasmic vesicle membrane TAS --
GO:0031988 membrane-bounded vesicle --
genes like me logo Genes that share ontologies with YWHAG: view

Pathways for YWHAG Gene

genes like me logo Genes that share pathways with YWHAG: view

Gene Ontology (GO) - Biological Process for YWHAG Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000086 G2/M transition of mitotic cell cycle TAS --
GO:0000278 mitotic cell cycle TAS --
GO:0006367 transcription initiation from RNA polymerase II promoter TAS --
GO:0006469 negative regulation of protein kinase activity NAS 10433554
GO:0006605 protein targeting IEA --
genes like me logo Genes that share ontologies with YWHAG: view

Compounds for YWHAG Gene

(2) Tocris Compounds for YWHAG Gene

Compound Action Cas Number
Difopein High affinity inhibitor of 14.3.3 proteins; induces apoptosis [396834-58-5]
R18 Inhibitor of 14.3.3 proteins; induces apoptosis [211364-78-2]

(2) HMDB Compounds for YWHAG Gene

Compound Synonyms Cas Number PubMed IDs
  • L-sepiapterin
  • Ambien
genes like me logo Genes that share compounds with YWHAG: view

Transcripts for YWHAG Gene

mRNA/cDNA for YWHAG Gene

(451) Selected AceView cDNA sequences:
(7) Additional mRNA sequences :
(1) REFSEQ mRNAs :
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for YWHAG Gene

Tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, gamma polypeptide:
Representative Sequences:

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for YWHAG

Primer Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for YWHAG Gene

No ASD Table

Relevant External Links for YWHAG Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for YWHAG Gene

mRNA expression in normal human tissues for YWHAG Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for YWHAG Gene

This gene is overexpressed in Brain - Frontal Cortex (BA9) (4.6) and Brain - Anterior cingulate cortex (BA24) (4.1).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for YWHAG Gene

SOURCE GeneReport for Unigene cluster for YWHAG Gene Hs.744840

mRNA Expression by UniProt/SwissProt for YWHAG Gene

Tissue specificity: Highly expressed in brain, skeletal muscle, and heart.
genes like me logo Genes that share expressions with YWHAG: view

Expression partners for YWHAG Gene

In Situ Assay Products

No data available for Protein differential expression in normal tissues for YWHAG Gene

Orthologs for YWHAG Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for YWHAG Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia YWHAG 35
  • 93.25 (n)
  • 100 (a)
  • 100 (a)
(Canis familiaris)
Mammalia YWHAG 35
  • 90.28 (n)
  • 98.78 (a)
  • 99 (a)
(Mus musculus)
Mammalia Ywhag 35
  • 92.44 (n)
  • 100 (a)
Ywhag 16
Ywhag 36
  • 100 (a)
(Pan troglodytes)
Mammalia YWHAG 35
  • 99.73 (n)
  • 100 (a)
  • 100 (a)
(Rattus norvegicus)
Mammalia Ywhag 35
  • 92.17 (n)
  • 100 (a)
(Monodelphis domestica)
Mammalia YWHAG 36
  • 100 (a)
(Gallus gallus)
Aves YWHAG 35
  • 89.88 (n)
  • 99.6 (a)
  • 100 (a)
(Anolis carolinensis)
Reptilia YWHAG 36
  • 100 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia ywhag 35
  • 81.92 (n)
  • 99.19 (a)
African clawed frog
(Xenopus laevis)
Amphibia MGC69099 35
(Danio rerio)
Actinopterygii ywhag 35
ywhag1 36
  • 96 (a)
ywhag2 36
  • 96 (a)
fruit fly
(Drosophila melanogaster)
Insecta 14-3-3zgr 37
  • 75 (a)
(Caenorhabditis elegans)
Secernentea M117.3 36
  • 40 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes BMH1 36
  • 56 (a)
BMH2 36
  • 55 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 47 (a)
-- 36
  • 51 (a)
-- 36
  • 61 (a)
CSA.10834 36
  • 60 (a)
CSA.10888 36
  • 53 (a)
CSA.11325 36
  • 51 (a)
Species with no ortholog for YWHAG:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for YWHAG Gene

Gene Tree for YWHAG (if available)
Gene Tree for YWHAG (if available)

Paralogs for YWHAG Gene

Paralogs for YWHAG Gene

Selected SIMAP similar genes for YWHAG Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with YWHAG: view

Variants for YWHAG Gene

Sequence variations from dbSNP and Humsavar for YWHAG Gene

SNP ID Clin Chr 07 pos Sequence Context AA Info Type MAF
rs887035 -- 76,354,073(-) TTTTT(G/T)TTTTT intron-variant
rs917422 -- 76,358,495(-) CCCGG(C/T)GCGGG intron-variant
rs917423 -- 76,355,400(-) TGTGT(C/T)TTTTG intron-variant
rs917424 -- 76,355,215(-) AGTTG(C/T)GTAAC intron-variant
rs1046304 -- 76,328,327(-) ACACT(G/T)AACTC utr-variant-3-prime

Structural Variations from Database of Genomic Variants (DGV) for YWHAG Gene

Variant ID Type Subtype PubMed ID
nsv528969 CNV Gain 19592680
essv14753 CNV CNV 17122850
dgv120n16 CNV Deletion 17901297
dgv2104e1 CNV Complex 17122850
nsv888387 CNV Loss 21882294
esv2422494 CNV Duplication 17116639
nsv428174 CNV Gain 18775914
esv2678206 CNV Deletion 23128226

Relevant External Links for YWHAG Gene

HapMap Linkage Disequilibrium report

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for YWHAG Gene

Disorders for YWHAG Gene

Relevant External Links for YWHAG

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator

No disorders were found for YWHAG Gene.

No data available for MalaCards , OMIM , UniProtKB/Swiss-Prot , University of Copenhagen DISEASES , Novoseek inferred disease relationships and Genatlas for YWHAG Gene

Publications for YWHAG Gene

  1. Cloning, expression, and chromosomal mapping of the human 14-3-3gamma gene (YWHAG) to 7q11.23. (PMID: 10486217) Horie M. … Tanigami A. (Genomics 1999) 2 3 4 23
  2. 14-3-3gamma interacts with and is phosphorylated by multiple protein kinase C isoforms in PDGF-stimulated human vascular smooth muscle cells. (PMID: 10433554) Autieri M.V. … Carbone C.J. (DNA Cell Biol. 1999) 2 3 4
  3. Reduced expression of 14-3-3 gamma in uterine leiomyoma as identified by proteomics. (PMID: 18054924) Lv J. … Zhu C. (Fertil. Steril. 2008) 3 23
  4. The DNA sequence of human chromosome 7. (PMID: 12853948) Hillier L.W. … Wilson R.K. (Nature 2003) 3 4
  5. A pathway of neuregulin-induced activation of cofilin-phosphatase Slingshot and cofilin in lamellipodia. (PMID: 15159416) Nagata-Ohashi K. … Mizuno K. (J. Cell Biol. 2004) 3 4

Products for YWHAG Gene

  • Addgene plasmids for YWHAG

Sources for YWHAG Gene

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