YWHAG Gene
protein-coding GIFtS: 66
GCID: GC07M075956
|
|
tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation...
| |
Aliases
for YWHAG gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| Tyrosine 3-Monooxygenase/Tryptophan 5-Monooxygenase Activation Protein,Gamma Polypeptide1 2 | | Protein Kinase C Inhibitor Protein 12 3 | | KCIP-12 3 | | 14-3-3 Gamma2 | | 14-3-3 Protein Gamma2 | | 14-3-3GAMMA2 |
Export aliases for YWHAG gene to outside databasesPrevious GC identifers: GC07M074491 GC07M075554 GC07M075568 GC07M075600 GC07M075794 GC07M071042 |
Summaries
for YWHAG gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
Entrez Gene summary for YWHAG:
This gene product belongs to the 14-3-3 family of proteins which mediate signal transduction by binding tophosphoserine-containing proteins. This highly conserved protein family is found in both plants and mammals, and thisprotein is 100% identical to the rat ortholog. It is induced by growth factors in human vascular smooth muscle cells,and is also highly expressed in skeletal and heart muscles, suggesting an important role for this protein in muscletissue. It has been shown to interact with RAF1 and protein kinase C, proteins involved in various signal transductionpathways. (provided by RefSeq, Jul 2008)
UniProtKB/Swiss-Prot: 1433G_HUMAN, P61981Function: Adapter protein implicated in the regulation of a large spectrum of both general and specialized signalingpathways. Binds to a large number of partners, usually by recognition of a phosphoserine or phosphothreonine motif.Binding generally results in the modulation of the activity of the binding partner
 summary
for YWHAG: 14.3.3 proteins are a group of highly conserved proteins that are involved in many vital cellular processes
such as metabolism, protein trafficking, signal transduction, apoptosis and cell cycle regulation. 14.3.3
proteins are phospho-serine/phospho-threonine binding proteins that have a diverse array of partners
including transcription factors, biosynthetic enzymes, cytoskeletal proteins, signalling molecules,
apoptosis factors and tumour suppressors. The 14.3.3 family consists of 7 isoforms; beta, gamma, epsilon,
sigma, zeta, tau and eta. 14.3.3 proteins are ubiquitously expressed and self assemble into homo- and
heterodimers, with the exception of 14.3.3sigma, which exclusively forms homodimers and is found in cells of
epithelial origin only. Each monomer contains an independent ligand-binding site, thus the 14.3.3 dimer can
interact with two target proteins simultaneously. 14.3.3 proteins are highly rigid structures and ligand
binding can induce conformational changes that alter the stability and/or catalytic activity of the ligand.
Furthermore, 14.3.3 protein binding can physically occlude sequence-specific or structural motifs on the
target that prevent molecular interactions and/or modulate the accessibility of a target protein to
modifying enzymes such as kinases, phosphatases and proteases. In addition, 14.3.3 proteins can act as a
scaffold molecule to anchor target proteins within close proximity of one another. 14.3.3 proteins represent
an integration point for proliferative, survival, apoptotic and stress signalling pathways. Members of the
14.3.3 protein family enhance the activity of many proteins with proliferative and/or survival functions,
such as Raf kinases, and antagonise the activity of proteins that promote cell death and senescence, such as
Bad, Bim and Bax. In contrast, 14.3.3sigma acts as a tumour suppressor and its expression is upregulated
coordinately with p53 and BRAC1. This isoform sequesters cdk1-cyclin B complexes in the cytoplasm, and thus
delays cell cycle progression. 14.3.3sigma is also a crucial regulator of translation during mitosis.
Because many 14.3.3 interactions are phosphorylation dependent, 14.3.3 proteins have been integrated into
the core regulatory pathways that are crucial for normal growth and development. 14.3.3 proteins are
directly involved in cellular processes such as cytokinesis, cell-contact inhibition, anchorage-independent
growth and cell adhesion, and it is these pathways that often become dysregulated in disease states such as
cancer.
Gene Wiki entry for YWHAG
|
Genomic Views
for YWHAG gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000007.13 NC_018918.1 NT_007933.15 NT_079595.2
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the YWHAG gene promoter:
c-Fos NF-1 NF-1/L AP-1 FosB YY1 CREB deltaCREB c-Jun Pax-4a
Other transcription factors
Search SABiosciences Chromatin IP Primers for YWHAG
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat YWHAG |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 7q11.23 Ensembl cytogenetic band: 7q11.23 HGNC cytogenetic band: 7q11.23YWHAG Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 7 GeneLoc Exon Structure GeneLoc location for GC07M075956: view genomic region
(about GC identifiers)
Start:
|
75,956,108 bp from pter |
End:
|
75,988,348 bp from pter |
Size:
|
32,241 bases |
Orientation:
|
minus strand |
1 alternative location:
| Chr7-,CRA_TCAG 75,289,172-75,321,406 |
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Proteins
for YWHAG gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: 1433G_HUMAN, P61981 (See
protein sequence)Recommended Name: 14-3-3 protein gamma Size: 247 amino acids; 28303 Da
Subunit: Homodimer. Interacts with SAMSN1 (By similarity). Interacts with RAF1, SSH1 and CRTC2/TORC2. Interacts withABL1 (phosphorylated form); the interaction retains it in the cytoplasm. Interacts with GAB2. Interacts with MDM4(phosphorylated); negatively regulates MDM4 activity toward TP53. Interacts with PKA-phosphorylated AANAT
Subcellular location: Cytoplasm (By similarity)
3 PDB 3D structures from  and Proteopedia  for YWHAG:2B05 (3D)
3UZD (3D)
4E2E (3D)
Secondary accessions: O70457 P35214 Q6FH52 Q9UDP2 Q9UN99Explore the universe of human proteins at neXtProt for YWHAG: NX_P61981
Post-translational modifications:
Phosphorylated by various PKC isozymes1
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_P61981
YWHAG Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins: NP_036611.2
ENSEMBL proteins: ENSP00000306330 Reactome Protein details: P61981
Human Recombinant Protein Products:
Gene Ontology (GO): 1 cellular component term (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0005829 | cytosol |
TAS | -- |
YWHAG for ontologies About GeneDecksing
YWHAG Antibody Products:
Assay Products for YWHAG: |
Protein
Domains /
Families
for YWHAG gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
YWHAG for domains About GeneDecksing
3 InterPro domains/families:Graphical View of Domain Structure for InterPro Entry P61981ProtoNet protein and cluster: P61981 1 Blocks protein family: IPB000308 14-3-3 protein
UniProtKB/Swiss-Prot: 1433G_HUMAN, P61981Similarity: Belongs to the 14-3-3 family |
Function
for YWHAG gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Function Summary:
UniProtKB/Swiss-Prot: 1433G_HUMAN, P61981Function: Adapter protein implicated in the regulation of a large spectrum of both general and specialized signalingpathways. Binds to a large number of partners, usually by recognition of a phosphoserine or phosphothreonine motif.Binding generally results in the modulation of the activity of the binding partner Genatlas biochemistry entry for YWHAG:tyrosine 3-monooxygenase/trytophan 5 monooxygenase activation protein,14-3-3 G, highly expressed in brain,skeletalmuscles,heat,located telomeric to D7S1870 at the most telomeric end of the common deletion of WBS1,multifunctionalregulator involved in cell-cyle control (checkpoint) and signal transduction,inhibitor of apoptosis through inhibitingthe activation of p38 MAP kinase
Clone
Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for YWHAG (see all 3)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for YWHAG (see all 2)
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling 
| |  | GenScript: all cDNA clones in your preferred vector: YWHAG (NM_012479) | |  | Sino Biological Human cDNA Clone for YWHAG | |  | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for YWHAG | |  | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat YWHAG |
In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for YWHAG |
Gene Ontology (GO): 5/6 molecular function terms (GO ID links to tree view) (see all 6): About this table
YWHAG for ontologies About GeneDecksing
1 GenomeRNAi human phenotype for YWHAG:
Animal Models:
Mouse knock-out Ywhagtm1Otto for YWHAG
1 MGI mutant phenotype (inferred from 1 allele ) (MGI details for Ywhag):
YWHAG for phenotypes About GeneDecksing
|
Pathways & Interactions
for YWHAG gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Unified GeneCards pathways - 5/47 super-pathways (see all 47) About this table
See pathways by source
| Super-pathway | contained gene-specific pathways |
|---|
| 1 | Recruitment of mitotic centrosome proteins and complexes | | | 2 | Activation of cAMP-Dependent PKA | | | 3 | Apoptosis and survival BAD phosphorylation | | | 4 | Cell cycle_Role of 14-3-3 proteins in cell cycle regulation | | | 5 | BH3-only proteins associate with and inactivate anti-apoptotic BCL-2 members | |
Pathway sources
See GeneCards unified pathways
Show all pathways
5 EMD Millipore Pathways for YWHAG
1  R&D Systems Pathway for YWHAG
5/19 Downloadable PowerPoint Slides of QIAGEN Pathway Central Maps for YWHAG (see all 19)
3 
Cell Signaling Technology (CST) Pathways for YWHAG
2 Tocris Bioscience Pathways for YWHAG
5  GeneGo (Thomson Reuters) Pathways for YWHAG
5/17  BioSystems Pathways for YWHAG (see all 17)
5/14 
Reactome Pathways for YWHAG (see all 14)
3 
Kegg Pathways (Kegg details for YWHAG):
YWHAG for pathways About GeneDecksing
Interactions:
SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for YWHAG
STRING Interaction
Network Preview (showing 5 interactants - click image to see 25)
5/756 Interacting proteins for YWHAG (P619811, 2, 3 ENSP000003063304) via UniProtKB, MINT, STRING, and/or I2D (see all 756)| Interactant | Interaction Details |
|---|
| GeneCard | External ID(s) |
|---|
| YWHAE | P622581, 2, 3, ENSP000002643354 | EBI-359832,EBI-356498 MINT-7300139 MINT-7899812 I2D:
score=6 STRING: ENSP00000264335 | | MDM4 | O151512, 3, ENSP000003561504 | MINT-1957780 MINT-1958362 MINT-1958118 MINT-1958145 MINT-1958602 MINT-1957996 MINT-1958083 I2D:
score=4 STRING: ENSP00000356150 | | TP53 | P046372, 3, ENSP000002693054 | MINT-8008679 MINT-8009392 MINT-8008658 MINT-8009385 MINT-8415355 MINT-8008651 MINT-8009378 I2D:
score=2 STRING: ENSP00000269305 | | TSC2 | P498152, 3, ENSP000002194764 | MINT-16555 MINT-16556 MINT-7899812 MINT-8006252 MINT-16557 I2D:
score=5 STRING: ENSP00000219476 | | YWHAQ | P273482, 3, ENSP000002380814 | MINT-7300139 MINT-8415355 MINT-7264099 MINT-7899812 I2D:
score=3 STRING: ENSP00000238081 |
About this table
Gene Ontology (GO): 5/7 biological process terms (GO ID links to tree view) (see all 7): About this table
YWHAG for ontologies About GeneDecksing
|
Drugs & Compounds
for YWHAG gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
Compounds for YWHAG available from Tocris Bioscience About this table
| Compound | Action |
CAS
# |
|---|
| Difopein | High affinity inhibitor of 14.3.3 proteins; induces apoptosis | [396834-58-5] | | R18 | Inhibitor of 14.3.3 proteins; induces apoptosis | [211364-78-2] |
2 HMDB Compounds for YWHAG About this table
Search CenterWatch for drugs/clinical trials and news about YWHAG / 1433G
|
Transcripts
for YWHAG gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for YWHAG gene: NM_012479.3 Unigene Cluster for YWHAG: Tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, gamma polypeptide Hs.520974 [show with all ESTs]Unigene Representative Sequence: NM_0124791 Ensembl transcript including schematic representation, and UCSC links where relevant: ENST00000307630(uc011kgj.1)
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for YWHAG (see all 3)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for YWHAG (see all 2)
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector: YWHAG (NM_012479) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for YWHAG | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat YWHAG |
Additional cDNA sequence: AB024334.1 AK024230.1 AK293505.1 AK295029.1 BC020963.2 CR541904.1 CR541925.1 10 DOTS entries: DT.100033100 DT.118888 DT.91775964 DT.95260521 DT.100827019 DT.100661295 DT.121118253 DT.95260518 DT.100827016 DT.95260522 24/451 AceView cDNA sequences (see all 451): N41045 BP358158 CB044902 CD516521 AI684319 AA995329 BU634095 AI978599 BM455143 AL537903 BQ937755 AA629231 AA548251 BP340024 BQ636437 AA983660 BQ004782 BM469294 BM999999 BM670118 AA137224 AA306169 AI380761 BM848036
GeneLoc Exon Structure
|
Expression
for YWHAG gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| YWHAG expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: AATGTGAGTC
About this image
See YWHAG Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for YWHAG
SOURCE GeneReport for Unigene cluster: Hs.520974
UniProtKB/Swiss-Prot: 1433G_HUMAN, P61981Tissue specificity: Highly expressed in brain, skeletal muscle, and heart
SABiosciences Custom PCR Arrays for YWHAG
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for YWHAG
Browse OriGene validated miRNA SYBR primer pairs
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse, rat YWHAG | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat YWHAG | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat YWHAG | In Situ
Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for YWHAG |
Orthologs
for YWHAG gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of eukaryotes.
Orthologs for YWHAG gene from 8/28 species (see all 28) About this table
ENSEMBL Gene Tree for YWHAG (if available)
TreeFam Gene Tree for YWHAG (if available) |
Paralogs
for YWHAG gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| Paralogs for YWHAG gene
- YWHAE2 YWHAH2 YWHAQ2 YWHAB2 SFN2 YWHAZ2
9 SIMAP similar genes for YWHAG using alignment to 1 protein entry: 1433G_HUMAN:YWHAH YWHAB YWHAZ SFN 14-3-3 protein YWHAQ
YWHAE YWHAE/FAM22A fusion YWHAE/FAM22B fusion
YWHAG for paralogs About GeneDecksing
|
Genomic Variants
for YWHAG gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 7 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for YWHAG (75956108 - 75988348 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 3 variations for YWHAG
3 CNVs: 3686 5241 22956 | SABiosciences Cancer Mutation PCR Assays |
|
Disorders
/ Diseases
for YWHAG gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
YWHAG for disorders About GeneDecksing
OMIM gene information: 605356
OMIM disorders: --
18  diseases for YWHAG: About MalaCardswilliams-beuren syndrome bacterial meningitis intellectual disability meningitis
insulin resistance lipodystrophy down syndrome multiple sclerosis
leiomyoma rhabdomyosarcoma hepatocellular carcinoma lung cancer
breast cancer schizophrenia immunodeficiency carcinoma
malaria neuronitis
Human Genome Epidemiology (HuGE) Navigator: YWHAG (1 document)
Export disorders for YWHAG gene to outside databases
|
Publications
for YWHAG gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for YWHAG gene, integrated from 9 sources (see all 133):
(articles sorted by number of sources associating them with YWHAG) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- Cloning, expression, and chromosomal mapping of the human 14-3-3gamma gene (YWHAG) to 7q11.23. (PubMed id 10486217)1, 2, 3, 9 Horie M.... Tanigami A. (1999)
- 14-3-3gamma interacts with and is phosphorylated by multiple protein kinase C isoforms in PDGF-stimulated human vascular smooth muscle cells. (PubMed id 10433554)1, 2, 3 Autieri M.V. and Carbone C.J. (1999)
- Phosphorylation-dependent binding of 14-3-3 terminates signalling by the Gab2 docking protein. (PubMed id 19172738)1, 2 Brummer T.... Daly R.J. (2008)
- 14-3-3gamma binds to MDMX that is phosphorylated by UV-activated Chk1, resulting in p53 activation. (PubMed id 16511572)1, 2 Jin Y....Lu H. (2006)
- JNK phosphorylation of 14-3-3 proteins regulates nuclear targeting of c-Abl in the apoptotic response to DNA damage. (PubMed id 15696159)1, 2 Yoshida K.... Miki Y. (2005)
- A pathway of neuregulin-induced activation of cofilin-phosphatase Slingshot and cofilin in lamellipodia. (PubMed id 15159416)1, 2 Nagata-Ohashi K.... Mizuno K. (2004)
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
- Exploring proteomes and analyzing protein processing by mass spectrometric identification of sorted N-terminal peptides. (PubMed id 12665801)1, 2 Gevaert K.... Vandekerckhove J. (2003)
- The DNA sequence of human chromosome 7. (PubMed id 12853948)1, 2 Hillier L.W.... Wilson R.K. (2003)
- Reduced expression of 14-3-3 gamma in uterine leiomyoma as identified by proteomics. (PubMed id 18054924)1, 9 Lv J....Zhu C. (2008)
|
External Searches for YWHAG gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
|
Genome Databases showing YWHAG gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing YWHAG gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing YWHAG gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
| Name | Description |
| PharmGKB entry for YWHAG | Pharmacogenomics, SNPs, Pathways |
|
| | |
About This Section
| Patent Information for YWHAG gene:
Search GeneIP for patents involving YWHAG
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for YWHAG gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
About This Section
|
 | |
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| | |  | OriGene Antibodies for YWHAG | | OriGene shRNA RFP for YWHAG | | | OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for YWHAG | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for YWHAG | | | OriGene Protein Over-expression Lysate for YWHAG | | Browse OriGene Fluorogenic Cell Assay Kits | | | OriGene siRNA for YWHAG | | OriGene 3'-UTR Clone for YWHAG | | | OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for YWHAG | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for YWHAG | | | Browse OriGene GFP tagged cDNA clones in CMV expression vector | | Browse OriGene MicroRNA Expression Plasmids | | | Browse OriGene basic RS shRNAs | | Browse OriGene validated miRNA SYBR primer pairs | | | OriGene Purified Protein for YWHAG | | OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling | | | OriGene Custom Antibody Services for YWHAG | | OriGene Custom Protein Services for YWHAG | | | OriGene Custom Immunoassay Development | | |
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| | | QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat YWHAG | | | Search QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing YWHAG | | | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat YWHAG | | | QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat YWHAG | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat YWHAG | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat YWHAG |
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| | Antibodies & Assays for YWHAG
(14-3-3 gamma) |
| | | | Tocris compounds for YWHAG |
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 | | | | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for YWHAG |
|  |  |  | | | | ThermoFisher Antibody for YWHAG |
| | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat YWHAG |
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