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YWHAE Gene

protein-coding GIFtS: 75

GC17M001194

tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, epsilon polypeptide
Symbol approved by the HUGO Gene Nomenclature Committee (HGNC) database

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc , and/or ⁷Ensembl, ⁸miRBase)
About This Section

Aliases
14-3-3E ^², ³
FLJ45465 ^¹, ²
KCIP-1 ^²
MDCR ^², ⁵
MDS ^², ⁵

Descriptions
14-3-3 epsilon ^²
mitochondrial import stimulation factor L subunit ^²
protein kinase C inhibitor protein-1 ^²
tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, epsilon polypeptide ^²
tyrosine 3/tryptophan 5 -monooxygenase activation protein, epsilon polypeptide ^²

External Ids
HGNC: 12851¹
Entrez Gene: 7531²
UniProtKB: P62258³
Ensembl: ENSG00000108953⁷

Search outside databases for aliases for YWHAE gene

Previous GC identifers: GC17P001321 GC17P001492 GC17M001198 GC17M001454

(According to Entrez Gene, Wikipedia's Gene Wiki,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

EntrezGene summary for YWHAE:

This gene product belongs to the 14-3-3 family of proteins which mediate signal transduction by

binding to phosphoserine-containing proteins. This highly conserved protein family is found in

both plants and mammals, and this protein is 100% identical to the mouse ortholog. It interacts

with CDC25 phosphatases, RAF1 and IRS1 proteins, suggesting its role in diverse biochemical

activities related to signal transduction, such as cell division and regulation of insulin

sensitivity. It has also been implicated in the pathogenesis of small cell lung cancer. Two

transcript variants, one protein-coding and the other non-protein-coding, have been found for this

gene. [provided by RefSeq]

UniProtKB/Swiss-Prot: 1433E_HUMAN, P62258

Function: Adapter protein implicated in the regulation of a large spectrum of both general and

specialized signaling pathway. Binds to a large number of partners, usually by recognition of a

phosphoserine or phosphothreonine motif. Binding generally results in the modulation of the

activity of the binding partner

Gene Wiki entry for YWHAE

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 36),
and/or miRBase,
Genomic Views according to UCSC and Ensembl, Transcription factor binding sites according to SABiosciences)
About This Section

Genomic View:

UCSC Golden Path with GeneCards custom track

Transcription factor binding sites upstream to the YWHAE gene

Entrez Gene cytogenetic band: 17p13.3 Ensembl cytogenetic band: 17p13.3 HGNC cytogenetic band: 17p13

YWHAE Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)

GeneLoc gene densities for chromosome 17 GeneLoc Exon Structure

GeneLoc location for GC17M001194: (about GC identifiers)

Start:	1,194,590 bp from pter
End:	1,250,267 bp from pter
Size:	55,678 bases
Orientation:	minus strand

RefSeq DNA sequence:

NC_000017.9 NT_010718.15

(According to ¹UniProtKB, and/or Ensembl, Phosphorylation sites according to ²Phosphosite, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Enzo Life Sciences, Abnova, OriGene and/or, Abcam,
Biochemical Assays by Invitrogen, Millipore, R&D Systems, Cell Signaling Technology, and/or Enzo Life Sciences, Ontologies according to Gene Ontology Consortium 01 Apr 2009 and Entrez Gene, Antibodies by Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Cell Signaling Technology, Abcam, Abnova, and/or Novus Biologicals)
About This Section

UniProtKB/Swiss-Prot: 1433E_HUMAN, P62258 (See protein sequence)

Recommended Name: 14-3-3 protein epsilon

Size: 255 amino acids; 29174 Da

Subunit: Homodimer. Heterodimerizes with YWHAZ. Interacts with NDEL1, RGNEF and TIAM2 (By

similarity). Interacts with HCV core protein. Interacts with ABL1 (phosphorylated form); the

interaction retains it in the cytoplasm. Weakly interacts with CDKN1B

Subcellular location: Cytoplasm (By similarity). Melanosome. Note=Identified by mass spectrometry

in melanosome fractions from stage I to stage IV

PDB structures from and Proteopedia :

2BR9 (3D)

Secondary accessions: B3KY71 P29360 P42655 Q53XZ5 Q63631 Q7M4R4

Post-translational modifications:

View phosphorylation sites using PhosphoSite²

REFSEQ proteins: NP_006752.1

ENSEMBL proteins:

ENSP00000264335

Human Recombinant Proteins

	Browse Drug Discovery Central at Invitrogen for human recombinant proteins
	Browse Purified and Recombinant Proteins at Millipore
	Browse Human Recombinant Proteins at Sigma-Aldrich
	Browse R&D Systems for human recombinant proteins
	Enzo Life Sciences proteins for YWHAE
	Recombinant Proteins from Abcam (14-3-3 beta + epsilon + zeta, 14-3-3 epsilon)
	Human Recombinant Proteins from Abnova (YWHAE)

Browse Origene for full length recombinant human proteins expressed in human HEK293 cells

3 Gene Ontology (GO) cellular component terms (links to tree view):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005737	cytoplasm	IEA	--
GO:0005739	mitochondrion	IEA	--
GO:0042470	melanosome	IEA	--

About this table

Antibodies for YWHAE:

	Invitrogen Antibodies for YWHAE
	Millipore Mono- and Polyclonal Antibodies for the study of YWHAE
	Sigma-Aldrich Antibodies for YWHAE
	R&D Systems Antibodies for YWHAE (14-3-3 epsilon)
	Cell Signaling Technology (CST) Antibodies for YWHAE (14-3-3 epsilon)
	Antibodies from Abcam (14-3-3 beta + epsilon + zeta, 14-3-3 epsilon), each with their Abpromise^SM
	Monoclonal and Polyclonal Antibodies from Abnova (YWHAE)
	Novus Biologicals Antibodies for YWHAE

Assays for YWHAE:

	Browse Invitrogen for biochemical assays
	Browse Kits and Assays available from Millipore
	Browse R&D Systems for biochemical assays
	Browse biochemical assays available from Enzo Life Sciences

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

Graphical View of Domain Structure for InterPro Entry P62258

ProtoNet protein and cluster: P62258

1 Blocks protein family: IPB000308 14-3-3 protein

UniProtKB/Swiss-Prot: 1433E_HUMAN, P62258

Similarity: Belongs to the 14-3-3 family

(According to MGI Jun 06 2009, UniProtKB, IUBMB,and/or Genatlas,
shRNA from OriGene, Sigma-Aldrich, RNAi from Sigma-Aldrich,
RNAi Products, Clones, and Q-PCR Products from Invitrogen, Millipore, OriGene, and/or Abnova, siRNAs from Applied Biosystems, SYBR primers from OriGene, Cell-based Assays from Millipore, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
About This Section

Inhib. RNA:		Invitrogen RNAi Products for gene knock-down (YWHAE)
		Browse for Gene Knock-down Tools from Millipore
		Abnova Chimera RNAi Products for Gene knock-down (YWHAE)

OriGene 29mer shRNA kit in GFP-retroviral vectors (see all 2): NM_006761

Applied Biosystems Silencer® siRNAs for YWHAE

Sigma-Aldrich siRNA for YWHAE

Sigma-Aldrich shRNA for YWHAE

Explore Sigma-Aldrich super-pooled esiRNAs

Clones:		Invitrogen Clones for YWHAE
		Browse Clones for the Expression of Recombinant Proteins Available from Millipore

OriGene GFP tagged cDNA clone in CMV expression vector: NM_006761
Myc/DDK tagged cDNA clone in CMV expression vector: NM_006761
untagged cDNA clones in CMV expression vector (see all 2): NM_006761

Primers:

Browse Quantitative PCR Central at Invitrogen for Q-PCR LUX™ Primers

OriGene genome-wide validated SYBR primer pairs: NM_006761

UniProtKB/Swiss-Prot: 1433E_HUMAN, P62258

Function: Adapter protein implicated in the regulation of a large spectrum of both general and

specialized signaling pathway. Binds to a large number of partners, usually by recognition of a

phosphoserine or phosphothreonine motif. Binding generally results in the modulation of the

activity of the binding partner

Genatlas biochemistry entry for YWHAE:

tyrosine 3-monooxygenase/trytophan 5 monooxygenase activation protein,14-3-3 epsilon

protein,multifunctional regulator involved in cell-cyle control (checkpoint) and signal

transduction,inhibitor of apoptosis through inhibiting the activation of p38 MAP kinase

2 MGI mutant phenotypes (inferred from 1 allele) (MGI details for Ywhae):

lethality-prenatal/perinatal

nervous system

2 Gene Ontology (GO) molecular function terms (links to tree view):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0019899	enzyme binding	IPI	10788521
GO:0019904	protein domain specific binding	IEA	--

About this table

(Pathways according to Invitrogen (maps by GeneGo), Millipore, Cell Signaling Technology, Sigma-Aldrich, KEGG and/or UniProtKB,
Sets of similar genes according to GeneDecks, Proteins Network according to SABiosciences, Interactions according to ¹UniProtKB, ²MINT, and/or ³STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
About This Section

5 Sigma-Aldrich "Your Favorite Gene" Pathways for YWHAE (Your Favorite Gene powered by Ingenuity)

IGF-1 Signaling
Cell Cycle: G2/M DNA Damage Checkpoint Regulation
VEGF Signaling
14-3-3-mediated Signaling
PI3K/AKT Signaling

GeneDecks YWHAE for the pathways selected above

About GeneDecksing

Gene Network Central^TM Interacting Genes and Proteins Network for YWHAE

5/158 Interacting proteins for YWHAE (ENSP00000264335³ P62258^{1, 2}) via UniProtKB, MINT, and/or STRING (see all 158 )

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
CDKN1B	P46527¹	STRING (score=.986) EBI-356498, EBI-519280
CDC25A	P30304²	STRING (score=.904) MINT-19304 MINT-19397 MINT-19303
CDC25B	P30305²	STRING (score=.998) MINT-51066 MINT-25123 MINT-51067
IGF1R	P08069²	STRING (score=.872) MINT-18626 MINT-18625 MINT-18624
IRS1	P35568²	STRING (score=.954) MINT-16661 MINT-16662

About this table

5/7 Gene Ontology (GO) biological process terms (links to tree view) (see all 7 ):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0001764	neuron migration	IEA	--
GO:0006605	protein targeting	IEA	--
GO:0007242	intracellular signaling cascade	TAS	7644510
GO:0021766	hippocampus development	IEA	--
GO:0021987	cerebral cortex development	IEA	--

About this table

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, Sigma-Aldrich, Tocris Bioscience, and/or Novoseek and Drugs according to Enzo Life Sciences and/or PharmGKB)
About This Section

Enzo Life Sciences drugs & compounds for YWHAE

Browse Small Molecules at Sigma-Aldrich

Compounds for YWHAE available from Tocris Bioscience

Compound	Action	CAS number
Difopein	High affinity inhibitor of 14.3.3 proteins; induces apoptosis	[396834-58-5]
R18	Inhibitor of 14.3.3 proteins; induces apoptosis	[211364-78-2]

About this table

(GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 219 Homo sapiens; Jun 2 2009) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView,
non coding RNAs according to RNAdb,
ESTs according to GeneTide,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from Invitrogen, Millipore, and/or Abnova,
siRNAs from Applied Biosystems, Sigma-Aldrich,
shRNA from Sigma-Aldrich, OriGene,
Tagged/untagged cDNA clones from OriGene,
Expression Assays from Applied Biosystems)
About This Section

Inhib. RNA:		Invitrogen RNAi Products for gene knock-down (YWHAE)
		Browse for Gene Knock-down Tools from Millipore
		Abnova Chimera RNAi Products for Gene knock-down (YWHAE)

OriGene 29mer shRNA kit in GFP-retroviral vectors (see all 2): NM_006761

Sigma-Aldrich siRNA for YWHAE

Sigma-Aldrich shRNA for YWHAE

Explore Sigma-Aldrich super-pooled esiRNAs

Applied Biosystems Silencer® siRNAs:

NM_006761

REFSEQ mRNAs for YWHAE gene:

NM_006761.4

Applied Biosystems TaqMan ® Gene Expression Assays:

NM_006761

              OriGene GFP tagged cDNA clone in CMV expression vector: NM_006761
                                 Myc/DDK tagged cDNA clone in CMV expression vector: NM_006761
                                 untagged cDNA clones in CMV expression vector (see all 2): NM_006761

Additional cDNA sequence:

AK128785.1 AK295260.1 AK295997.1 AK296050.1 AK296555.1 AK316185.1 AK316201.1 AY883089.1

BC000179.2 BC001440.2 BT007161.1 CR589991.1 CR593257.1 CR594680.1 CR595118.1 CR599291.1

CR600610.1 CR605234.1 CR608365.1 CR609747.1 CR609773.1 CR609824.1 CR610427.1 CR610584.1

CR611764.1 CR612456.1 CR615586.1 CR617332.1 CR619511.1 CR620149.1 CR622415.1 CR622589.1

CR623549.1 CR624231.1 U20972.1 U28936.1 U43399.1 U43430.1 U54778.1

24/55 DOTS entries (see all 55 ):

DT.95260129 DT.97862705 DT.100893739 DT.100800719 DT.100893703 DT.99950231 DT.97861309 DT.97862704

DT.95190057 DT.100893702 DT.95260196 DT.95260150 DT.95260250 DT.100893733 DT.100893742 DT.99978845

DT.454468 DT.120963813 DT.100893735 DT.100893724 DT.120963642 DT.92369109 DT.95260146 DT.40248808

24/1840 AceView cDNA sequences (see all 1840 ):

BM800485 BP362796 BP371029 CB162626 BU679101 BP336365 AA401509 BM759754

BQ428088 AA724377 BM721057 CB106695 BE883274 AA161462 BU159664 BQ921611

BM753140 CB306219 BU173200 BP372499 AI131480 AA404741 BM473686 AU123723

highest scoring ESTs for YWHAE:

U54778 BM753140 CB112914 CB117752 CB118066 BE698832 BQ368139 AA083002 AA093671 AA160983

Unigene Cluster for YWHAE:

Tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, epsilon polypeptide

Hs.513851 [show with all ESTs]

Unigene Representative Sequence: NM_006761

GeneLoc Exon Structure

5/6 Alternative Splicing Database (ASD) splice patterns (SP) for YWHAE (see all 6 )

ExUns:	1a	·	1b	·	1c	·	1d	^	2	^	3a	·	3b	^	4a	·	4b	^	5a	·	5b	^	6	^	7	^	8a	·	8b	·	8c	·	8d
SP1:									-				-												-
SP2:									-		-		-				-								-
SP3:													-
SP4:
SP5:									-				-		-		-		-		-		-		-

About this scheme

ECgene alternative splicing isoforms for YWHAE

1 Ensembl transcript including schematic representation:

ENST00000264335

(Experimental results according to ¹GeneNote and GNF BioGPS,
probe sets-to-genes annotations according to ²GeneAnnot , ³GeneTide , Sets of similar genes according to GeneDecks, Electronic Northern calculations according to data from UniGene (Build 219 Homo sapiens), SAGE tags according to CGAP, plus additional links to SOURCE, and/or GNF BioGPS, and/or EXPOLDB, and/or UniProtKB,
Expression Assays from Applied Biosystems )
About This Section

YWHAE expression in normal and diseased human tissues

Applied Biosystems TaqMan ® Gene Expression Assays for YWHAE

¹ / ² / ³

5 probe-sets matching YWHAE gene

Affymetrix probe-set	Array	# genes	Sensitivity	Specificity	Correlation	Length	Gb_Accession	Consensus	Uniqueness	Score	Rank
Affymetrix probe-set	Array	GeneAnnot data			GeneNote data		GeneTide data
1011_s_at²^{, 3}	U95-A	2	1.00	0.81	1.00	1.00	U54778	1.00	0.80	0.91	1
210996_s_at²^{, 3}	U133-A	2	1.00	0.82	--	--	U43430	0.80	0.75	0.78	1
210317_s_at²^{, 3}	U133-A	5	1.00	0.58	--	--	U28936	0.80	0.75	0.78	1
210996_s_at²	U133Plus2	2	1.00	0.82	--	--	--	--	--	--	--
210317_s_at²	U133Plus2	5	1.00	0.58	--	--	--	--	--	--	--

GeneDecks YWHAE for binary patterns associated with the probe-sets selected above

About GeneDecksing

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Data from

(Publications) and GNF BioGPS
About these images
About these images

CGAP SAGE TAG: GAATTAACAT

SOURCE GeneReport for Unigene cluster: Hs.513851
Expression variation in blood from EXPOLDB for YWHAE

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD and/or ⁵MGI Jun 06 2009, with possible further links to Flybase and/or WormBase, Gene Trees according to Ensembl)
About This Section

Orthologs for YWHAE gene from 5/24 species (see all 24 )

Organism	Gene	Locus	Description	Human Similarity	NCBI accessions
dog (Canis familiaris)	YWHAE¹	--	tyrosine 3-monooxygenase/tryptophan 5-monooxygenase more	97.52(n) 100(a)	480645 XM_849265.1 XP_854358.1
chimpanzee (Pan troglodytes)	YWHAE¹	--	tyrosine 3-monooxygenase/tryptophan 5-monooxygenase more	99.87(n) 100(a)	454409 XM_001153770.1 XP_001153770.1
cow (Bos taurus)	YWHAE¹	--	tyrosine 3-monooxygenase/tryptophan 5-monooxygenase more	97.78(n) 100(a)	282125 NM_174491.3 NP_776916.1
rat (Rattus norvegicus)	Ywhae¹	--	tyrosine 3-monooxygenase/tryptophan 5-monooxygenase more	92.68(n) 98.82(a)	29753 NM_031603.1 NP_113791.1
mouse (Mus musculus)	Ywhae^{1, 5}	11 (44.17 cM)⁵	tyrosine 3-monooxygenase/tryptophan 5-monooxygenase more^{1, 5}	93.33(n)¹ 99.61(a)¹	22627¹ NM_009536.3¹ NP_033562.2¹ AF483478⁵ AF483479⁵ (see all 41)

About this table Species with no ortholog for YWHAE

ENSEMBL Gene Tree for YWHAE

(Paralogs according to ¹HomoloGene
and ²Ensembl, Pseudogenes according to ³Pseudogene.org)
About This Section

Paralogs for YWHAE gene

YWHAH² YWHAG²

(According to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, and UniProtKB, Linkage Disequilibrium by HapMap, Genotyping Reagents from Applied Biosystems)
About This Section

10/395 NCBI SNPs in YWHAE are shown (see all 395 )
(Click for Applied Biosystems TaqMan ® Genotyping Assay) (see all 88)

AB	SNP ID	Valid	Chr 17 pos	Sequence	Recs	AA Chg	Type	More	Recs	Pop	Total sample	More
AB	Genomic Data				Transcription Data				Allele Frequencies
				--	--	--		--	--			--
--	rs7266^1,2	C,F,H,O	1195216(-)	`TTACTG/ATGTCG`	1	--	ut3¹ ese³		8	MN EU EA WA NA	738
--	rs9393^1,2	A,C,F,H	1195142(-)	`ACTTAT/CAGGTG`	1	--	ut3¹ ese³		10	EA MN EU WA	2484
--	rs15219^1,2	C	1194712(-)	`GTAACT/GTGAAG`	1	--	ut3¹		1	MN	184
	rs1873827^1,2	A,C,F,H,O	1247690(+)	`TTACCT/CTCTTC`	1	--	int¹		9	MN EU EA WA NA	964
	rs2131431^1,2	A,C,F,H,O	1241645(-)	`AGTCAG/TGGCCC`	1	--	int¹		12	EU EA WA NA	1056
	rs2131432^1,2	A,C,F,H,O	1244222(+)	`tcataG/Aaaaaa`	1	--	int¹		16	EU EA WA NA	1474
	rs9895157^1,2	A,C,F,H	1218985(+)	`AATATT/CATTCC`	1	--	int¹		4	EU EA WA	416
	rs7214541^1,2	A,C,F,H	1220072(+)	`agacaA/Gtgaag`	1	--	int¹		7	EU EA WA NA	558
	rs7208041^1,2	A,C,F,H	1217312(+)	`agcacA/Gctgat`	1	--	int¹		4	EU EA WA	418
	rs4790082^1,2	A,C,F,H	1225450(+)	`TTTGCA/GGCAAG`	1	--	int¹		4	EU EA WA	420

About this table

HapMap Linkage Disequilibrium images for YWHAE (up to first 250kb)

(in which this Gene is Involved, According to OMIM, UniProtKB, PharmGKB, Genatlas, GeneTests, Blood group antigen gene mutations by BGMUT, HGMD, GAD, HuGE Navigator, BCGD, and/or TGDB.)
About This Section

OMIM: 605066 disorders: 247200

Human Gene Mutation Database: YWHAE
Genetic Association Database: YWHAE
Human Genome Epidemiology Navigator: YWHAE (1 document)

(Possibly Related Articles in Doctor's Guide)
About This Section

(in PubMed. Associations of this gene to articles via ¹Novoseek, ²HGNC, ³Entrez Gene, ⁴UniProtKB/Swiss-Prot, ⁵UniProtKB/TrEMBL, ⁶GAD, and/or ⁷PharmGKB)
About This Section

10/98 PubMed articles for YWHAE gene (see all 98 ):

Proteomic and bioinformatic characterization of the biogenesis and function of melanosomes. (PubMed id 17081065)^{3, 4} Chi A....Hunt D.F. (2006)
Association of 14-3-3 epsilon gene haplotype with completed suicide in Japanese. (PubMed id 15838597)^{3, 6} Yanagi M....Maeda K. (2005)
Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)^{3, 4} Ota T....Sugano S. (2004)
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)^{3, 4} Gerhard D.S....Malek J. (2004)
Exploring proteomes and analyzing protein processing by mass spectrometric identification of sorted N-terminal peptides. (PubMed id 12665801)^{3, 4} Gevaert K.... Vandekerckhove J. (2003)
Akt-dependent phosphorylation of p27Kip1 promotes binding to 14-3-3 and cytoplasmic localization. (PubMed id 12042314)^{3, 4} Fujita N....Tsuruo T. (2002)
Hepatitis C virus core protein interacts with 14-3-3 protein and activates the kinase Raf-1. (PubMed id 10644344)^{3, 4} Aoki H.... Hino O. (2000)
Assignment of the human 14-3-3 epsilon isoform (YWHAE) to human chromosome 17p13 by in situ hybridization. (PubMed id 9371399)^{2, 3} Luk S.C....Waye M.M. (1997)
14-3-3 epsilon has no homology to LIS1 and lies telomeric to it on chromosome 17p13.3 outside the Miller-Dieker syndrome chromosome region. (PubMed id 8858348)^{3, 4} Chong S.S.... Ledbetter D.H. (1996)
Function of 14-3-3 proteins. (PubMed id 8684458)^{3, 4} Jin D.-Y.... Jeang K.-T. (1996)

(in PubMed, OMIM, and NCBI Bookshelf)
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		AND	OR
Aliases
Free Text

Query String		PubMed OMIM NCBI Bookshelf
	(Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, and/or H-InvDB)
About This Section

Entrez Gene: 7531	HGNC: 12851	AceView: YWHAE	Ensembl:ENSG00000108953	euGenes: HUgn7531
ECgene: YWHAE	H-InvDB: YWHAE

(According to HUGE)
About This Section

(According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section

Name	Description
ATLAS Chromosomes in Cancer entry for YWHAE	Genetics and Cytogenetics in Oncology and Haematology

Licensable Technologies for YWHAE
(Available from WIS Yeda, Salk, Tufts)

About This Section

(Reagents available from Applied Biosystems, Antibodies and assays by Cell Signaling Technology, Abcam, Novus Biologicals,
Sigma-Aldrich, R&D Systems, Millipore, Abnova, and/or Invitrogen, Clones available from OriGene,and/or Invitrogen, Drugs and/or compounds by Sigma-Aldrich,
Enzo Life Sciences, and/or Tocris Bioscience)
About This Section

Products for YWHAE:

TaqMan ® Gene Expression Assays

TaqMan ® Genotyping Assays

Free SNP selection tool

Invitrogen iPath Pathways	Invitrogen BLOCK-iT™ RNAi
Invitrogen Antibodies	Invitrogen Assays
Invitrogen Clones	Invitrogen Q-PCR Products
Invitrogen Human Recombinant Kinases	Invitrogen Custom Antibody and Peptide Service
Invitrogen Proteins / Assays / Screening Services	Search Invitrogen catalog for YWHAE-related products

	Millipore Custom Antibody & Bulk Services
	Millipore Preclinical / Clinical Development Services
	Millipore Immunoassay Services
	Millipore Target Screening & Profiling Services

	Predesigned and custom siRNAs for YWHAE		Antibodies for YWHAE
	Explore super-pooled esiRNAs		Browse proteins at Sigma-Aldrich
	Lentivirus-delivered shRNAs for YWHAE		Browse small molecules at Sigma-Aldrich
	"Your Favorite Gene" Pathways		feedback

	Antibodies		Primer Pairs
	Cell Culture Products		ELISAs
	Flow Cytometry Kits		Protease Activity Assays & Reagents
	Cell Selection/Detection Kits & Reagents		ELISA/Assay Development Kits & Reagents
	Multiplex/Array Assay Kits & Reagents		ELISpot Kits & Development Modules
	Recombinant & Natural Proteins

	Recombinant Proteins (YWHAE)
	Antibodies (YWHAE)
	Chimera RNAi (YWHAE)
	Custom Service for Mouse Mab
	Custom Service for Rabbit Pab from Full-length Protein

Antibodies & Assays for YWHAE (14-3-3 epsilon)

	Recombinant Proteins (14-3-3 beta + epsilon + zeta, 14-3-3 epsilon)
	Antibodies (14-3-3 beta + epsilon + zeta, 14-3-3 epsilon)

Search OriGene for YWHAE

Tocris compounds for YWHAE

	Drugs/Proteins for YWHAE
	Search www.enzolifesicences.com for proteins, assays, substrates, inhibitors & antibodies

Antibodies for YWHAE

GeneCards Homepage - Last full update: 2 Jul 2009 Incremental update: 13 Oct 2009

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Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

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YWHAE Gene

protein-coding GIFtS: 75

Aliases &
Descriptions
for YWHAE

Summaries
for YWHAE

Genomic Location
for YWHAE

Proteins
for YWHAE

Protein Domains/
Families
for YWHAE

Gene Function
for YWHAE

Pathways & Interactions
for YWHAE

Drugs & Compounds
for YWHAE

Transcripts
for YWHAE

Expression
for YWHAE

Orthologs
for YWHAE

Paralogs
for YWHAE

SNPs/Variants
for YWHAE

Disorders & Mutations
for YWHAE

Medical News
for YWHAE

Publications
for YWHAE

Search for YWHAE

Genome Databases showing YWHAE

Other Databases showing YWHAE

Specialized Databases showing YWHAE

Licensable Technologies
for YWHAE

Services
for YWHAE

Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

YWHAE Gene

protein-coding GIFtS: 75

Aliases & Descriptionsfor YWHAE

Summariesfor YWHAE

Genomic Locationfor YWHAE

Proteinsfor YWHAE

Protein Domains/Familiesfor YWHAE

Gene Functionfor YWHAE

Pathways & Interactionsfor YWHAE

Drugs & Compoundsfor YWHAE

Transcriptsfor YWHAE

Expression for YWHAE

Orthologsfor YWHAE

Paralogsfor YWHAE

SNPs/Variantsfor YWHAE

Disorders & Mutationsfor YWHAE

Medical Newsfor YWHAE

Publicationsfor YWHAE

Search for YWHAE

Genome Databases showing YWHAE

Other Databases showing YWHAE

Specialized Databases showing YWHAE

Licensable Technologiesfor YWHAE

Servicesfor YWHAE

Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

Aliases &
Descriptions
for YWHAE

Summaries
for YWHAE

Genomic Location
for YWHAE

Proteins
for YWHAE

Protein Domains/
Families
for YWHAE

Gene Function
for YWHAE

Pathways & Interactions
for YWHAE

Drugs & Compounds
for YWHAE

Transcripts
for YWHAE

Expression
for YWHAE

Orthologs
for YWHAE

Paralogs
for YWHAE

SNPs/Variants
for YWHAE

Disorders & Mutations
for YWHAE

Medical News
for YWHAE

Publications
for YWHAE

Licensable Technologies
for YWHAE

Services
for YWHAE