YWHAE Gene
protein-coding GIFtS: 72
GCID: GC17M001247
|
|
tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation...
| |
Aliases
for YWHAE gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| Tyrosine 3-Monooxygenase/Tryptophan 5-Monooxygenase Activation Protein,Epsilon Polypeptide1 2 | | 14-3-3 Protein Epsilon2 | | 14-3-3E2 3 | | KCIP-12 | | MDCR2 5 | | Mitochondrial Import Stimulation Factor L Subunit2 | | MDS2 5 | | Protein Kinase C Inhibitor Protein-12 | | FLJ454651 | | Tyrosine 3/Tryptophan 5 -Monooxygenase Activation Protein, Epsilon Polypeptide2 | | 14-3-3 Epsilon2 | | |
Export aliases for YWHAE gene to outside databasesPrevious GC identifers: GC17P001321 GC17P001492 GC17M001198 GC17M001454 GC17M001194 GC17M001148 |
Summaries
for YWHAE gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
Entrez Gene summary for YWHAE:
This gene product belongs to the 14-3-3 family of proteins which mediate signal transduction by binding tophosphoserine-containing proteins. This highly conserved protein family is found in both plants and mammals, and thisprotein is 100% identical to the mouse ortholog. It interacts with CDC25 phosphatases, RAF1 and IRS1 proteins,suggesting its role in diverse biochemical activities related to signal transduction, such as cell division andregulation of insulin sensitivity. It has also been implicated in the pathogenesis of small cell lung cancer. Twotranscript variants, one protein-coding and the other non-protein-coding, have been found for this gene. (provided byRefSeq, Aug 2008)
UniProtKB/Swiss-Prot: 1433E_HUMAN, P62258Function: Adapter protein implicated in the regulation of a large spectrum of both general and specialized signalingpathways. Binds to a large number of partners, usually by recognition of a phosphoserine or phosphothreonine motif.Binding generally results in the modulation of the activity of the binding partner
 summary
for YWHAE: 14.3.3 proteins are a group of highly conserved proteins that are involved in many vital cellular processes
such as metabolism, protein trafficking, signal transduction, apoptosis and cell cycle regulation. 14.3.3
proteins are phospho-serine/phospho-threonine binding proteins that have a diverse array of partners
including transcription factors, biosynthetic enzymes, cytoskeletal proteins, signalling molecules,
apoptosis factors and tumour suppressors. The 14.3.3 family consists of 7 isoforms; beta, gamma, epsilon,
sigma, zeta, tau and eta. 14.3.3 proteins are ubiquitously expressed and self assemble into homo- and
heterodimers, with the exception of 14.3.3sigma, which exclusively forms homodimers and is found in cells of
epithelial origin only. Each monomer contains an independent ligand-binding site, thus the 14.3.3 dimer can
interact with two target proteins simultaneously. 14.3.3 proteins are highly rigid structures and ligand
binding can induce conformational changes that alter the stability and/or catalytic activity of the ligand.
Furthermore, 14.3.3 protein binding can physically occlude sequence-specific or structural motifs on the
target that prevent molecular interactions and/or modulate the accessibility of a target protein to
modifying enzymes such as kinases, phosphatases and proteases. In addition, 14.3.3 proteins can act as a
scaffold molecule to anchor target proteins within close proximity of one another. 14.3.3 proteins represent
an integration point for proliferative, survival, apoptotic and stress signalling pathways. Members of the
14.3.3 protein family enhance the activity of many proteins with proliferative and/or survival functions,
such as Raf kinases, and antagonise the activity of proteins that promote cell death and senescence, such as
Bad, Bim and Bax. In contrast, 14.3.3sigma acts as a tumour suppressor and its expression is upregulated
coordinately with p53 and BRAC1. This isoform sequesters cdk1-cyclin B complexes in the cytoplasm, and thus
delays cell cycle progression. 14.3.3sigma is also a crucial regulator of translation during mitosis.
Because many 14.3.3 interactions are phosphorylation dependent, 14.3.3 proteins have been integrated into
the core regulatory pathways that are crucial for normal growth and development. 14.3.3 proteins are
directly involved in cellular processes such as cytokinesis, cell-contact inhibition, anchorage-independent
growth and cell adhesion, and it is these pathways that often become dysregulated in disease states such as
cancer.
Gene Wiki entry for YWHAE
|
Genomic Views
for YWHAE gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000017.10 NC_018928.1 NT_010718.16
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the YWHAE gene promoter:
RFX1 C/EBPbeta NF-kappaB YY1 E47 NF-kappaB2 Hand1 LyF-1 Pax-4a NF-kappaB1
Other transcription factors
Search SABiosciences Chromatin IP Primers for YWHAE
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat YWHAE |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 17p13.3 Ensembl cytogenetic band: 17p13.3 HGNC cytogenetic band: 17p13.3YWHAE Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 17 GeneLoc Exon Structure GeneLoc location for GC17M001247: view genomic region
(about GC identifiers)
Start:
|
1,247,566 bp from pter |
End:
|
1,303,672 bp from pter |
Size:
|
56,107 bases |
Orientation:
|
minus strand |
|
Proteins
for YWHAE gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: 1433E_HUMAN, P62258 (See
protein sequence)Recommended Name: 14-3-3 protein epsilon Size: 255 amino acids; 29174 Da
Subunit: Homodimer. Heterodimerizes with YWHAZ. Interacts with NDEL1, ARHGEF28 and TIAM2 (By similarity). Interactswith HCV core protein. Interacts with ABL1 (phosphorylated form); the interaction retains it in the cytoplasm. Weaklyinteracts with CDKN1B. Interacts with GAB2. Interacts with phosphorylated GRB10. Interacts with PKA-phosphorylatedAANAT. Interacts with the phosphorylated (by AKT1) form of SRPK2
Subcellular location: Cytoplasm (By similarity). Melanosome. Note=Identified by mass spectrometry in melanosomefractions from stage I to stage IV
3 PDB 3D structures from  and Proteopedia  for YWHAE:2BR9 (3D)
3UAL (3D)
3UBW (3D)
Secondary accessions: B3KY71 D3DTH5 P29360 P42655 Q4VJB6 Q53XZ5 Q63631 Q7M4R4Alternative splicing: 2 isoforms: P62258-1 P62258-2 (Unable to dimerize with YWHAZ)Explore the universe of human proteins at neXtProt for YWHAE: NX_P62258
Post-translational modifications:
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_P62258
YWHAE Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins: NP_006752.1
ENSEMBL proteins: ENSP00000264335 ENSP00000464883 ENSP00000461762 ENSP00000458386 ENSP00000466324 ENSP00000461766 ENSP00000460712 Reactome Protein details: P62258
Human Recombinant Protein Products:
Gene Ontology (GO): 5/6 cellular component terms (GO ID links to tree view) (see all 6): About this table
YWHAE for ontologies About GeneDecksing
YWHAE Antibody Products:
Assay Products for YWHAE: |
Protein
Domains /
Families
for YWHAE gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
YWHAE for domains About GeneDecksing
3 InterPro domains/families:Graphical View of Domain Structure for InterPro Entry P62258ProtoNet protein and cluster: P62258 1 Blocks protein family: IPB000308 14-3-3 protein
UniProtKB/Swiss-Prot: 1433E_HUMAN, P62258Similarity: Belongs to the 14-3-3 family |
Function
for YWHAE gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Function Summary:
UniProtKB/Swiss-Prot: 1433E_HUMAN, P62258Function: Adapter protein implicated in the regulation of a large spectrum of both general and specialized signalingpathways. Binds to a large number of partners, usually by recognition of a phosphoserine or phosphothreonine motif.Binding generally results in the modulation of the activity of the binding partner Genatlas biochemistry entry for YWHAE:tyrosine 3-monooxygenase/trytophan 5 monooxygenase activation protein,14-3-3 epsilon protein,multifunctional regulatorinvolved in cell-cyle control (checkpoint) and signal transduction,inhibitor of apoptosis through inhibiting theactivation of p38 MAP kinase
Clone
Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for YWHAE (see all 3)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for YWHAE (see all 2)
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling 
| |  | GenScript: all cDNA clones in your preferred vector: YWHAE (NM_006761) | |  | Sino Biological Human cDNA Clone for YWHAE | |  | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for YWHAE | |  | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat YWHAE |
In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for YWHAE |
Gene Ontology (GO): 5/7 molecular function terms (GO ID links to tree view) (see all 7): About this table
YWHAE for ontologies About GeneDecksing
1 GenomeRNAi human phenotype for YWHAE:
Animal Models:
Mouse knock-out Ywhaetm1Awb for YWHAE
3 MGI mutant phenotypes (inferred from 1 allele ) (MGI details for Ywhae):
YWHAE for phenotypes About GeneDecksing
|
Pathways & Interactions
for YWHAE gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Unified GeneCards pathways - 5/59 super-pathways (see all 59) About this table
See pathways by source
| Super-pathway | contained gene-specific pathways |
|---|
| 1 | Recruitment of mitotic centrosome proteins and complexes | | | 2 | Activation of cAMP-Dependent PKA | | | 3 | Apoptosis and survival BAD phosphorylation | | | 4 | Cell cycle_Role of 14-3-3 proteins in cell cycle regulation | | | 5 | BH3-only proteins associate with and inactivate anti-apoptotic BCL-2 members | |
Pathway sources
See GeneCards unified pathways
Show all pathways
5 EMD Millipore Pathways for YWHAE
1  R&D Systems Pathway for YWHAE
5/19 Downloadable PowerPoint Slides of QIAGEN Pathway Central Maps for YWHAE (see all 19)
4 
Cell Signaling Technology (CST) Pathways for YWHAE
2 Tocris Bioscience Pathways for YWHAE
5  GeneGo (Thomson Reuters) Pathways for YWHAE
5/22  BioSystems Pathways for YWHAE (see all 22)
5/20 
Reactome Pathways for YWHAE (see all 20)
3 
Kegg Pathways (Kegg details for YWHAE):
YWHAE for pathways About GeneDecksing
Interactions:
SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for YWHAE
STRING Interaction
Network Preview (showing 5 interactants - click image to see 25)
5/1217 Interacting proteins for YWHAE (P622581, 2, 3 ENSP000002643354) via UniProtKB, MINT, STRING, and/or I2D (see all 1217)About this table
Gene Ontology (GO): 5/13 biological process terms (GO ID links to tree view) (see all 13): About this table
YWHAE for ontologies About GeneDecksing
|
Drugs & Compounds
for YWHAE gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
Compounds for YWHAE available from Tocris Bioscience About this table
| Compound | Action |
CAS
# |
|---|
| Difopein | High affinity inhibitor of 14.3.3 proteins; induces apoptosis | [396834-58-5] | | R18 | Inhibitor of 14.3.3 proteins; induces apoptosis | [211364-78-2] |
1 DrugBank Compound for YWHAE About this table
Search CenterWatch for drugs/clinical trials and news about YWHAE / 1433E
|
Transcripts
for YWHAE gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for YWHAE gene: NM_006761.4 Unigene Cluster for YWHAE: Tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, epsilon polypeptide Hs.513851 [show with all ESTs]Unigene Representative Sequence: NR_02405813 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000264335(uc002fsk.3 uc002fsj.3 uc010vqh.2 uc010vqi.2)
ENST00000466227 ENST00000571732 ENST00000573026 ENST00000496706 ENST00000573196
ENST00000575977 ENST00000469398 ENST00000486241 ENST00000489287 ENST00000576854
ENST00000572108 ENST00000498643
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for YWHAE (see all 3)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for YWHAE (see all 2)
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector: YWHAE (NM_006761) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for YWHAE | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat YWHAE |
Additional cDNA sequence: AK128785.1 AK295260.1 AK295997.1 AK296050.1 AK296555.1 AK316185.1 AK316201.1 AY883089.1 BC000179.2 BC001440.2 BT007161.1 NR_024058.1 U20972.1 U28936.1 U43399.1 U43430.1 U54778.1 24/62 DOTS entries (see all 62): DT.95260129 DT.97862705 DT.100893739 DT.100800719 DT.100893703 DT.97861309 DT.99950231 DT.97862704 DT.100893702 DT.95190057 DT.95260150 DT.95260196 DT.95260250 DT.100893733 DT.100893742 DT.99978845 DT.454468 DT.120963813 DT.100893735 DT.100893724 DT.120963642 DT.92369109 DT.95260146 DT.100893737 24/1840 AceView cDNA sequences (see all 1840): BQ959619 BQ026829 AK128785 W49810 AA166760 CR612456 BG248635 BP372499 U28936 BG681498 CA444511 BU169832 BP376428 CB162626 CB151995 AA189010 CR620149 BU687723 CA445857 AA188949 CA441848 BQ879806 M78473 W48829
GeneLoc Exon Structure
5/6 Alternative Splicing Database (ASD) splice patterns (SP) for YWHAE (see all 6) About this scheme
| ExUns: | 1a | · | 1b | · | 1c | · | 1d | ^ | 2 | ^ | 3a | · | 3b | ^ | 4a | · | 4b | ^ | 5a | · | 5b | ^ | 6 | ^ | 7 | ^ | 8a | · | 8b | · | 8c | · | 8d |
|---|
|
| SP1: | | | | | | | | | - | | | | - | | | | | | | | | | | | - | | | | | | | | | | |
| SP2: | | | | | | | | | - | | - | | - | | | | - | | | | | | | | - | | | | | | | | | | |
| SP3: | | | | | | | | | | | | | - | | | | | | | | | | | | | | | | | | | | | | |
| SP4: | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | |
| SP5: | | | | | | | | | - | | | | - | | - | | - | | - | | - | | - | | - | | | | | | | | | |
ECgene alternative splicing isoforms for YWHAE
|
Expression
for YWHAE gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| YWHAE expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: GAATTAACAT
About this image
See YWHAE Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for YWHAE
SOURCE GeneReport for Unigene cluster: Hs.513851
SABiosciences Expression via Pathway-Focused PCR Array including YWHAE:
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for YWHAE
Browse OriGene validated miRNA SYBR primer pairs
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse, rat YWHAE | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat YWHAE | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat YWHAE | In Situ
Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for YWHAE |
Orthologs
for YWHAE gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of eukaryotes.
Orthologs for YWHAE gene from 6/33 species (see all 33) About this table
| Organism |
Taxonomic
classification |
Gene |
Description |
Human
Similarity |
Orthology
Type |
Details |
chicken
(Gallus gallus) |
Aves |
YWHAE1 |
tyrosine 3-monooxygenase/tryptophan 5-monooxygenase more |
92.16(n)
100(a) |
|
417554 NM_001006219.1 NP_001006219.1 |
African clawed frog
(Xenopus laevis) |
Amphibia |
ywhae-prov2 |
tyrosine 3-monooxygenase/tryptophan 5-monooxygenase more |
89.81(n) |
|
BC045025.1 |
zebrafish
(Danio rerio) |
Actinopterygii |
Dr.14122 |
Danio rerio mRNA similar to tyrosine 3-monooxygenase/tryptophan more |
80.73(n) |
|
BC045325.1 |
fruit fly
(Drosophila melanogaster) |
Insecta |
14-3-3&egr;3
14-3-3epsilon1 |
DNA damage checkpoint
diacylglycerol-activated/phospholipid
more3
14-3-3e1 |
83(a)
(best of 2)3
70.87(n)1
84.65(a)1 |
|
421861 NM_169796.21 NP_732309.11 |
thale cress
(Arabidopsis thaliana) |
eudicotyledons |
GRF111 |
general regulatory factor 11 |
64.78(n)
72.98(a) |
|
840380 NM_103196.3 NP_564451.2 |
rice
(Oryza sativa) |
Liliopsida |
Os.34402 |
Oryza sativa mRNA for 14-3-3-like protein (gf14-e gene) |
75.02(n) |
|
AJ276594.1 |
ENSEMBL Gene Tree for YWHAE (if available)
TreeFam Gene Tree for YWHAE (if available) |
Paralogs
for YWHAE gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| Paralogs for YWHAE gene
- YWHAH2 YWHAQ2 YWHAB2 YWHAG2 SFN2 YWHAZ2
9 SIMAP similar genes for YWHAE using alignment to 6 protein entries: 1433E_HUMAN (see all proteins):YWHAE/FAM22A fusion YWHAE/FAM22B fusion YWHAZ YWHAQ YWHAG 14-3-3 protein
SFN YWHAB YWHAH
YWHAE for paralogs About GeneDecksing
5/15 Pseudogenes.org Pseudogenes for YWHAE (see all 15)
PGOHUM00000259158 PGOHUM00000259161 PGOHUM00000259165 PGOHUM00000259170 PGOHUM00000262354
|
Genomic Variants
for YWHAE gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 17 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for YWHAE (1247566 - 1303672 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV) variations for YWHAE: --
Human Gene Mutation Database (HGMD): YWHAE
| SABiosciences Cancer Mutation PCR Assays |
| 1 SABiosciences qBiomarker Copy Number PCR Array containing YWHAE: |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing YWHAE |
|
Disorders
/ Diseases
for YWHAE gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
YWHAE for disorders About GeneDecksing
OMIM gene information: 605066
OMIM disorders: --
20/29  diseases for YWHAE (see all 29): About MalaCardsgerstmann-straussler-scheinker disease miller-dieker syndrome lung cancer major depressive disorder
corpus callosum neuronal migration disorders spinocerebellar ataxia retinitis pigmentosa
insulin resistance kidney sarcoma bipolar disorder lissencephaly
lipodystrophy multiple sclerosis hepatitis c ataxia
medulloblastoma hepatocellular carcinoma neurodegeneration retinitis
1 disease from the University of Copenhagen DISEASES database for YWHAE:Lissencephaly Genetic Association Database (GAD): YWHAE
Human Genome Epidemiology (HuGE) Navigator: YWHAE (3 documents)
Export disorders for YWHAE gene to outside databases
|
Publications
for YWHAE gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for YWHAE gene, integrated from 9 sources (see all 212):
(articles sorted by number of sources associating them with YWHAE) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- Functional identification of a novel 14-3-3 epsilon s plicing variant suggests dimerization is not necessary for 14-3-3 epsilon to in hibit UV-induced apoptosis. (PubMed id 20417184)1, 2 Han D....Yu L. (2010)
- Phosphorylation-dependent binding of 14-3-3 terminates signalling by the Gab2 docking protein. (PubMed id 19172738)1, 2 Brummer T.... Daly R.J. (2008)
- Proteomic and bioinformatic characterization of the biogenesis and function of melanosomes. (PubMed id 17081065)1, 2 Chi A....Hunt D.F. (2006)
- Protein kinase A phosphorylates and regulates dimerization of 14-3-3 epsilon. (PubMed id 16376338)1, 2 Gu Y.-M.... Lee K.-Y. (2006)
- Association of 14-3-3 epsilon gene haplotype with completed suicide in Japanese. (PubMed id 15838597)1, 4 Yanagi M....Maeda K. (2005)
- Phosphorylation of grb10 regulates its interaction with 14-3-3. (PubMed id 15722337)1, 2 Urschel S....Duyster J. (2005)
- JNK phosphorylation of 14-3-3 proteins regulates nuclear targeting of c-Abl in the apoptotic response to DNA damage. (PubMed id 15696159)1, 2 Yoshida K.... Miki Y. (2005)
- Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
- Exploring proteomes and analyzing protein processing by mass spectrometric identification of sorted N-terminal peptides. (PubMed id 12665801)1, 2 Gevaert K.... Vandekerckhove J. (2003)
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External Searches for YWHAE gene
(in PubMed,
OMIM, and NCBI Bookshelf)
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Genome Databases showing YWHAE gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
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Other Databases showing YWHAE gene
(According to HUGE)
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Specialized Databases showing YWHAE gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
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About This Section
| Patent Information for YWHAE gene:
Search GeneIP for patents involving YWHAE
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
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Products
for YWHAE gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
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| | |  | OriGene Antibodies for YWHAE | | OriGene shRNA RFP for YWHAE | | | OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for YWHAE | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for YWHAE | | | OriGene Protein Over-expression Lysate for YWHAE | | Browse OriGene Fluorogenic Cell Assay Kits | | | OriGene siRNA for YWHAE | | OriGene 3'-UTR Clone for YWHAE | | | OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for YWHAE | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for YWHAE | | | Browse OriGene GFP tagged cDNA clones in CMV expression vector | | Browse OriGene MicroRNA Expression Plasmids | | | Browse OriGene basic RS shRNAs | | Browse OriGene validated miRNA SYBR primer pairs | | | OriGene Purified Protein for YWHAE | | OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling | | | OriGene Custom Antibody Services for YWHAE | | OriGene Custom Protein Services for YWHAE | | | OriGene Custom Immunoassay Development | | |
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| | | QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat YWHAE | | | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing YWHAE | | | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat YWHAE | | | QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat YWHAE | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat YWHAE | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat YWHAE |
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| | Antibodies & Assays for YWHAE
(14-3-3 epsilon) |
| | | | Tocris compounds for YWHAE |
| |  |  |  |  | | | | | | Recombinant Protein for YWHAE |
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 | | | | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for YWHAE |
|  |  |  | | | | ThermoFisher Antibody for YWHAE |
| | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat YWHAE |
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