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YWHAB Gene

protein-coding   GIFtS: 70
GCID: GC20P043515

Tyrosine 3-Monooxygenase/Tryptophan 5-Monooxygenase Activation...

(Previous names: tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation...)
(Previous symbol: YWHAA)
  Search for YWHAB
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Tyrosine 3-Monooxygenase/Tryptophan 5-Monooxygenase Activation Protein,
Beta1 2
     14-3-3 Beta1
YWHAA1 2     14-3-3 Protein Beta/Alpha2
Tyrosine 3-Monooxygenase/Tryptophan 5-Monooxygenase Activation Protein,
Alpha Polypeptide1 2
     GW1282
Tyrosine 3-Monooxygenase/Tryptophan 5-Monooxygenase Activation Protein,
Beta Polypeptide1 2
     HEL-S-12
14-3-3 Alpha1 2     HS12
Protein 10542 3     Brain Protein 14-3-3, Beta Isoform2
Protein Kinase C Inhibitor Protein 12 3     Epididymis Secretory Protein Li 12
KCIP-12 3     Protein Kinase C Inhibitor Protein-12

External Ids:    HGNC: 128491   Entrez Gene: 75292   Ensembl: ENSG000001669137   OMIM: 6012895   UniProtKB: P319463   

Export aliases for YWHAB gene to outside databases

Previous GC identifers: GC20P043242 GC20P043202 GC20P044152 GC20P044199 GC20P042947 GC20P040256


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for YWHAB Gene:
This gene encodes a protein belonging to the 14-3-3 family of proteins, members of which mediate signal
transduction by binding to phosphoserine-containing proteins. This highly conserved protein family is found in
both plants and mammals. The encoded protein has been shown to interact with RAF1 and CDC25 phosphatases,
suggesting that it may play a role in linking mitogenic signaling and the cell cycle machinery. Two transcript
variants, which encode the same protein, have been identified for this gene. (provided by RefSeq, Jul 2008)

GeneCards Summary for YWHAB Gene:
YWHAB (tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, beta) is a protein-coding gene. GO annotations related to this gene include protein C-terminus binding and enzyme binding. An important paralog of this gene is YWHAH.

UniProtKB/Swiss-Prot: 1433B_HUMAN, P31946
Function: Adapter protein implicated in the regulation of a large spectrum of both general and specialized
signaling pathways. Binds to a large number of partners, usually by recognition of a phosphoserine or
phosphothreonine motif. Binding generally results in the modulation of the activity of the binding partner.
Negative regulator of osteogenesis. Blocks the nuclear translocation of the phosphorylated form (by AKT1) of
SRPK2 and antagonizes its stimulatory effect on cyclin D1 expression resulting in blockage of neuronal apoptosis
elicited by SRPK2

summary for YWHAB Gene:
14.3.3 proteins are a group of highly conserved proteins that are involved in many vital cellular processes
such as metabolism, protein trafficking, signal transduction, apoptosis and cell cycle regulation. 14.3.3
proteins are phospho-serine/phospho-threonine binding proteins that have a diverse array of partners
including transcription factors, biosynthetic enzymes, cytoskeletal proteins, signalling molecules,
apoptosis factors and tumour suppressors. The 14.3.3 family consists of 7 isoforms; beta, gamma, epsilon,
sigma, zeta, tau and eta. 14.3.3 proteins are ubiquitously expressed and self assemble into homo- and
heterodimers, with the exception of 14.3.3sigma, which exclusively forms homodimers and is found in cells of
epithelial origin only. Each monomer contains an independent ligand-binding site, thus the 14.3.3 dimer can
interact with two target proteins simultaneously. 14.3.3 proteins are highly rigid structures and ligand
binding can induce conformational changes that alter the stability and/or catalytic activity of the ligand.
Furthermore, 14.3.3 protein binding can physically occlude sequence-specific or structural motifs on the
target that prevent molecular interactions and/or modulate the accessibility of a target protein to
modifying enzymes such as kinases, phosphatases and proteases. In addition, 14.3.3 proteins can act as a
scaffold molecule to anchor target proteins within close proximity of one another. 14.3.3 proteins represent
an integration point for proliferative, survival, apoptotic and stress signalling pathways. Members of the
14.3.3 protein family enhance the activity of many proteins with proliferative and/or survival functions,
such as Raf kinases, and antagonise the activity of proteins that promote cell death and senescence, such as
Bad, Bim and Bax. In contrast, 14.3.3sigma acts as a tumour suppressor and its expression is upregulated
coordinately with p53 and BRAC1. This isoform sequesters cdk1-cyclin B complexes in the cytoplasm, and thus
delays cell cycle progression. 14.3.3sigma is also a crucial regulator of translation during mitosis.
Because many 14.3.3 interactions are phosphorylation dependent, 14.3.3 proteins have been integrated into
the core regulatory pathways that are crucial for normal growth and development. 14.3.3 proteins are
directly involved in cellular processes such as cytokinesis, cell-contact inhibition, anchorage-independent
growth and cell adhesion, and it is these pathways that often become dysregulated in disease states such as
cancer.

Gene Wiki entry for YWHAB Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000020.10  NC_018931.2  NT_011362.11  
Regulatory elements:
   Regulatory transcription factor binding sites in the YWHAB gene promoter:
         MEF-2   E47   CREB   MEF-2A   POU2F1   FOXJ2 (long isoform)   POU2F1a   Hand1   FOXJ2   aMEF-2   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidYWHAB promoter sequence
   Search Chromatin IP Primers for YWHAB

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat YWHAB


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 20q13.1   Ensembl cytogenetic band:  20q13.12   HGNC cytogenetic band: 20q13.1

YWHAB Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
YWHAB gene location

GeneLoc information about chromosome 20         GeneLoc Exon Structure

GeneLoc location for GC20P043515:  view genomic region     (about GC identifiers)

Start:
43,514,317 bp from pter      End:
43,537,173 bp from pter
Size:
22,857 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., and/or eBioscience,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., and/or eBioscience, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: 1433B_HUMAN, P31946 (See protein sequence)
Recommended Name: 14-3-3 protein beta/alpha  
Size: 246 amino acids; 28082 Da
Subunit: Homodimer. Interacts with SAMSN1 and PRKCE (By similarity). Interacts with SSH1 and TORC2/CRTC2.
Interacts with ABL1; the interaction results in cytoplasmic location of ABL1 and inhibition of cABL-mediated
apoptosis. Interacts with ROR2 (dimer); the interaction results in phosphorylation of YWHAB on tyrosine residues.
Interacts with GAB2 and YAP1 (phosphorylated form). Interacts with the phosphorylated (by AKT1) form of SRPK2.
Interacts with PKA-phosphorylated AANAT
3 PDB 3D structures from and Proteopedia for YWHAB:
2BQ0 (3D)        2C23 (3D)        4DNK (3D)    
Secondary accessions: A8K9K2 E1P616
Alternative initiation: 2 isoforms:  P31946-1   P31946-2   (Contains a N-acetylmethionine at position 1 (By similarity))

Explore the universe of human proteins at neXtProt for YWHAB: NX_P31946

Explore proteomics data for YWHAB at MOPED

Post-translational modifications: 

  • The alpha, brain-specific form differs from the beta form in being phosphorylated (By similarity). Phosphorylated
    on Ser-60 by protein kinase C delta type catalytic subunit in a sphingosine-dependent fashion (By similarity)1
  • Isoform Short contains a N-acetylmethionine at position 1 (By similarity)1
  • Ubiquitination2 at Lys11, Lys13, Lys51, Lys70, Lys117, Lys122, Lys124, Lys140, Lys160
  • Modification sites at PhosphoSitePlus

  • See YWHAB Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (2 alternative transcripts): 
    NP_003395.1  NP_647539.1  

    ENSEMBL proteins: 
     ENSP00000300161   ENSP00000361930   ENSP00000394729   ENSP00000394558  
    Reactome Protein details: P31946

    YWHAB Human Recombinant Protein Products:

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    Novus Biologicals YWHAB Proteins
    Novus Biologicals YWHAB Lysates
    Sino Biological Recombinant Protein for YWHAB
    Browse Sino Biological Cell Lysates
    ProSpec Recombinant Protein for YWHAB
    Browse Proteins at Cloud-Clone Corp.

     
    Search eBioscience for Proteins for YWHAB 

    YWHAB Antibody Products:

    EMD Millipore Mono- and Polyclonal Antibodies for the study of YWHAB
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    Novus Biologicals YWHAB Antibodies
    Abcam antibodies for YWHAB (P63104, P31946)
    Browse Antibodies at Cloud-Clone Corp.
    ThermoFisher Antibody for YWHAB
    LSBio Antibodies in human, mouse, rat for YWHAB

    YWHAB Assay Products:

    Browse Kits and Assays available from EMD Millipore
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    Browse Enzo Life Sciences for kits & assays
    Browse ELISAs at Cloud-Clone Corp.
    Browse CLIAs at Cloud-Clone Corp.
    Search eBioscience for ELISAs for YWHAB 


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    3 InterPro protein domains:
     IPR023409 14-3-3_CS
     IPR023410 14-3-3_domain
     IPR000308 14-3-3

    Graphical View of Domain Structure for InterPro Entry P31946

    ProtoNet protein and cluster: P31946

    1 Blocks protein domain: IPB000308 14-3-3 protein

    UniProtKB/Swiss-Prot: 1433B_HUMAN, P31946
    Similarity: Belongs to the 14-3-3 family


    Find genes that share domains with YWHAB           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: 1433B_HUMAN, P31946
    Function: Adapter protein implicated in the regulation of a large spectrum of both general and specialized
    signaling pathways. Binds to a large number of partners, usually by recognition of a phosphoserine or
    phosphothreonine motif. Binding generally results in the modulation of the activity of the binding partner.
    Negative regulator of osteogenesis. Blocks the nuclear translocation of the phosphorylated form (by AKT1) of
    SRPK2 and antagonizes its stimulatory effect on cyclin D1 expression resulting in blockage of neuronal apoptosis
    elicited by SRPK2

         Genatlas biochemistry entry for YWHAB:
    tyrosine 3-monooxygenase/trytophan 5 monooxygenase activation protein,14-3-3 beta protein,including the
    phosphorylated form YWHAA (alpha),multifunctional regulator involved in cell-cyle control (checkpoint) and signal
    transduction,inhibitor of apoptosis through inhibiting the activation of p38 MAP kinase

         Gene Ontology (GO): Selected molecular function terms (see all 9):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003714transcription corepressor activity IEA--
    GO:0005515protein binding IPI10713667
    GO:0008022protein C-terminus binding IEA--
    GO:0019899enzyme binding IPI17255105
    GO:0019904protein domain specific binding IPI11984006
         
    Find genes that share ontologies with YWHAB           About GenesLikeMe


    Animal Models:
       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for YWHAB
       inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for YWHAB

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for YWHAB
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for YWHAB

    miRNA
    Products:
        
    miRTarBase miRNAs that target YWHAB:
    hsa-mir-877-3p (MIRT037014), hsa-mir-1301-3p (MIRT035990), hsa-mir-378a-5p (MIRT044012), hsa-mir-221-3p (MIRT046917)

    Block miRNA regulation of human, mouse, rat YWHAB using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate YWHAB (see all 42):
    hsa-miR-124* hsa-miR-4291 hsa-miR-429 hsa-miR-128 hsa-miR-759 hsa-miR-183* hsa-miR-1276 hsa-miR-200b
    SwitchGear 3'UTR luciferase reporter plasmidYWHAB 3' UTR sequence
    Inhib. RNA
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    OriGene RNAi products in human, mouse, rat for YWHAB
    Predesigned siRNA for gene silencing in human, mouse, rat YWHAB

    Gene Editing
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    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 2): YWHAB (NM_139323)
    Sino Biological Human cDNA Clone for YWHAB
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    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat YWHAB
    Addgene plasmids for YWHAB 

    Cell Line
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    Browse ESI BIO Cell Lines and PureStem Progenitors for YWHAB 
    In Situ Assay
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for YWHAB


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    1433B_HUMAN, P31946: Cytoplasm. Melanosome. Note=Identified by mass spectrometry in melanosome fractions from
    stage I to stage IV
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    cytosol4
    cytoskeleton3
    nucleus3
    golgi apparatus1

    Gene Ontology (GO): Selected cellular component terms (see all 9):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus ----
    GO:0005737cytoplasm IDA--
    GO:0005829cytosol TAS--
    GO:0017053transcriptional repressor complex IEA--
    GO:0030659cytoplasmic vesicle membrane TAS--

    Find genes that share ontologies with YWHAB           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for YWHAB About   (see all 71)  
    See pathways by source

    SuperPathSelected contained pathways About (see all per SuperPath)
    1Cell cycle
    Cell cycle0.59
    Cell cycle0.59
    2Development IGF 1 receptor signaling
    Development IGF RI signaling0.49
    Development IGF 1 receptor signaling0.48
    3Cell cycle Role of 14 3 3 proteins in cell cycle regulation
    Cell cycle Role of 14 3 3 proteins in cell cycle regulation0.45
    14-3-3 and Cell Cycle Regulation0.45
    4Development Dopamine D2 receptor transactivation of EGFR
    Apoptosis and survival BAD phosphorylation0.41
    BAD Phosphorylation0.41
    5Signaling by FGFR
    Signaling by FGFR0.91
    DAP12 interactions0.89
    Signaling by FGFR in disease0.91
    Signaling by PDGF0.87
    Downstream signaling of activated FGFR0.91
    Signaling by EGFR0.83
    Downstream signal transduction0.90
    Signaling by EGFR in Cancer0.82


    Find genes that share SuperPaths with YWHAB           About GenesLikeMe

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    1 R&D Systems Pathway for YWHAB
        Apoptosis Signaling Pathways

    Selected Downloadable PowerPoint Slides of GeneGlobe Pathway Central Maps for YWHAB (see all 18)
        14-3-3 Induced Apoptosis
    DHA Signaling
    PKA Signaling
    ERK5 Signaling
    BDNF Pathway

    4 Cell Signaling Technology (CST) Pathways for YWHAB
        MAP Kinase Signaling
    Apoptosis and Autophagy
    Cell Cycle / Checkpoint Control
    Tyrosine Kinases / Adaptors

    2 Tocris Bioscience Pathways for YWHAB
        Insulin Pathway
    Apoptosis Pathway

    Selected GeneGo (Thomson Reuters) Pathways for YWHAB (see all 7)
        Apoptosis and survival BAD phosphorylation
    Development Role of HDAC and calcium/calmodulin-dependent kinase (CaMK) in control of skeletal myogenesis
    Development IGF-1 receptor signaling
    Cytoskeleton remodeling Role of PKA in cytoskeleton reorganisation
    Immune response Function of MEF2 in T lymphocytes

    Selected BioSystems Pathways for YWHAB (see all 20)
        Myometrial Relaxation and Contraction Pathways
    Cell cycle
    EGFR1 Signaling Pathway
    SIDS Susceptibility Pathways
    Calcium Regulation in the Cardiac Cell


    Selected Reactome Pathways for YWHAB (see all 11)
        MEK activation
    Frs2-mediated activation
    Signaling by Hippo
    Butyrate Response Factor 1 (BRF1) destabilizes mRNA
    Activation of BAD and translocation to mitochondria


    Selected Kegg Pathways  (Kegg details for YWHAB) (see all 7):
        Cell cycle
    Oocyte meiosis
    PI3K-Akt signaling pathway
    Hippo signaling pathway
    Hepatitis B

        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for YWHAB
    Interactions:

        GeneGlobe Interaction Network for YWHAB

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for YWHAB (P319461, 2, 3 ENSP000003001614) via UniProtKB, MINT, STRING, and/or I2D (see all 1063)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    TSC2P498151, 2, 3, ENSP000002194764EBI-359815,EBI-396587 MINT-8009815 MINT-8006263 MINT-15978 MINT-50944 MINT-8006321 MINT-15979 MINT-17162 MINT-15977 I2D: score=6 STRING: ENSP00000219476
    ENSG00000237724P081072, 3, ENSP000004063594MINT-50346 I2D: score=4 STRING: ENSP00000406359
    HSPA1AP081072, 3, ENSP000003648024MINT-50346 I2D: score=4 STRING: ENSP00000364802
    ENSG00000212866P081072, 3MINT-50346 I2D: score=4 
    ENSG00000215328P081072, 3MINT-50346 I2D: score=4 
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 25):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000165MAPK cascade TAS--
    GO:0000186activation of MAPKK activity TAS--
    GO:0006605protein targeting IEA--
    GO:0006915apoptotic process TAS--
    GO:0007173epidermal growth factor receptor signaling pathway TAS--

    Find genes that share ontologies with YWHAB           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Compounds for YWHAB available from Tocris Bioscience    About this table
    CompoundAction CAS #
    DifopeinHigh affinity inhibitor of 14.3.3 proteins; induces apoptosis[396834-58-5]
    R18Inhibitor of 14.3.3 proteins; induces apoptosis[211364-78-2]

    2 HMDB Compounds for YWHAB    About this table
    CompoundSynonyms CAS #PubMed Ids
    SepiapterinL-sepiapterin (see all 8)17094-01-8--
    ZolpidemAmbien (see all 7)82626-48-0--

    1 Novoseek inferred chemical compound relationship for YWHAB gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    serine 28.2 1 16469478 (1)



    Find genes that share compounds with YWHAB           About GenesLikeMe



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for YWHAB gene (2 alternative transcripts): 
    NM_003404.4  NM_139323.3  

    Unigene Cluster for YWHAB:

    Tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, beta polypeptide
    Hs.643544  [show with all ESTs]
    Unigene Representative Sequence: AB209759
    7 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000353703(uc002xmu.3) ENST00000479421 ENST00000372839(uc002xmt.3)
    ENST00000428262 ENST00000445830 ENST00000477896 ENST00000479758
    miRNA
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    Selected qRT-PCR Assays for microRNAs that regulate YWHAB (see all 42):
    hsa-miR-124* hsa-miR-4291 hsa-miR-429 hsa-miR-128 hsa-miR-759 hsa-miR-183* hsa-miR-1276 hsa-miR-200b
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    Addgene plasmids for YWHAB 
    Primer
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      QuantiTect SYBR Green Assays in human, mouse, rat YWHAB
      QuantiFast Probe-based Assays in human, mouse, rat YWHAB

    Additional mRNA sequence: 

    AB209759.1 AB451260.1 AB451386.1 AF064847.1 AF107406.1 AK292717.1 AL834170.1 BC001359.2 
    BC010352.1 X57346.1 

    Selected DOTS entries (see all 49):

    DT.75122682  DT.100883284  DT.87077844  DT.100883297  DT.92325870  DT.100883281  DT.100883300  DT.100059833 
    DT.92007444  DT.95256702  DT.120826031  DT.100883289  DT.95118446  DT.95151426  DT.100883292  DT.120826074 
    DT.100883274  DT.100059820  DT.95151410  DT.120826094  DT.91772166  DT.100883277  DT.95151421  DT.100883266 

    Selected AceView cDNA sequences (see all 1367):

    AW472766 BQ183152 BU540599 AA167429 CD743146 AA459239 BM843443 BM758152 
    CB119741 F05953 H39869 AA854663 N33792 BM754925 BM830874 BF718694 
    AW467473 CB140640 T33559 BQ679676 AA614855 BQ893661 T48550 BM709010 

    GeneLoc Exon Structure

    Selected Alternative Splicing Database (ASD) splice patterns (SP) for YWHAB (see all 10)    About this scheme

    ExUns: 1a · 1b ^ 2 ^ 3a · 3b ^ 4a · 4b · 4c · 4d ^ 5a · 5b · 5c ^ 6a · 6b ^ 7a · 7b ^ 8 ^ 9a · 9b · 9c
    SP1:              -     -                             -     -     -     -                                                   
    SP2:              -     -     -                       -     -     -     -                                                   
    SP3:                                                                                                                        
    SP4:                                                  -                                                                     
    SP5:                    -                                                                                                   


    ECgene alternative splicing isoforms for YWHAB

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

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    YWHAB expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: CAGTTACTTA
    YWHAB Expression
    About this image


    YWHAB expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 19) fully expand
     
     Brain (Nervous System)    fully expand to see all 4 entries
             Cerebral Cortex
     
     Ovary (Reproductive System)    fully expand to see all 2 entries
             Ovarian Mesenchymal Stroma Cells Ovary Interstitium
             Oviduct
     
     Testis (Reproductive System)
             Leydig Cells Testis Interstitium
     
     Trophoblast (Extraembryonic Tissues)
             Trophoblast Cells Trophoblast
     
     Bone (Muscoskeletal System)
             Bone Marrow
    YWHAB Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    YWHAB Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.643544
        Custom PCR Arrays for YWHAB
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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of animals.

    Orthologs for YWHAB gene from Selected species (see all 16)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Ywhab1 , 5 tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, beta polypeptide less1, 5 90.65(n)1
    98.78(a)1
      2 (84.59 cM)5
    544011  NM_018753.61  NP_061223.21 
     1639949605 
    chicken
    (Gallus gallus)
    Aves YWHAB1 tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, beta polypeptide less 84.7(n)
    97.95(a)
      419190  NM_001006289.1  NP_001006289.1 
    lizard
    (Anolis carolinensis)
    Reptilia YWHAB6
    tyrosine 3-monooxygenase/tryptophan 5-monooxygenas...
    97(a)
    1 ↔ 1
    4(143599734-143603777)
    African clawed frog
    (Xenopus laevis)
    Amphibia M86928.12   -- 79.86(n)    M86928.1 
    zebrafish
    (Danio rerio)
    Actinopterygii CA473362.12   -- 81.66(n)   323055  CA473362.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta 14-3-3&zgr;3 RAS protein signal transduction
    diacylglycerol-activated/phospholipid
    dependent protein kinase C inhibitor less
    79(a)     --
    worm
    (Caenorhabditis elegans)
    Secernentea ftt-26
    par-56
    Protein PAR-5 (par-5) mRNA, complete cds
    77(a)
    75(a)
    many ↔ many
    many ↔ many
    X(11603707-11605412) WBGene00001502
    IV(11820505-11821917) WBGene00003920


    ENSEMBL Gene Tree for YWHAB (if available)
    TreeFam Gene Tree for YWHAB (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for YWHAB gene
    YWHAH2  YWHAE2  YWHAQ2  YWHAG2  SFN2  YWHAZ2  
    9 SIMAP similar genes for YWHAB using alignment to 4 protein entries:     1433B_HUMAN (see all proteins):
    YWHAZ    YWHAQ    14-3-3 protein    YWHAH    SFN    YWHAG
    YWHAE/FAM22B fusion    YWHAE/FAM22A fusion    YWHAE

    Find genes that share paralogs with YWHAB           About GenesLikeMe


    2 Pseudogenes.org Pseudogenes for YWHAB
    PGOHUM00000242182 PGOHUM00000236462


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
    About This Section

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    Selected SNPs for YWHAB (see all 537)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 20 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1510645291,2
    C--43512385(+) ATGAC-/AGATAAC 2 -- us2k10--------
    rs1913506431,2
    --43512426(+) AAGGGA/TCCCTG 2 -- us2k10--------
    rs1831176381,2
    --43512526(+) TTACCA/TGACAA 2 -- us2k10--------
    rs1874088011,2
    --43512558(+) TCACAC/TAGAAA 2 -- us2k10--------
    rs1392160041,2
    C--43512560(+) ACACAC/GAAACT 2 -- us2k10--------
    rs1925536461,2
    --43512679(+) GGGGAA/GAAATA 2 -- us2k10--------
    rs1832246841,2
    --43512692(+) AGCTAA/CAGGAT 2 -- us2k10--------
    rs114804481,2
    C--43512853(+) TGAGAG/-CCAAA 2 -- us2k11Minor allele frequency- -:0.50CSA 2
    rs764568311,2
    C--43512854(+) TGAGAG/CCAAAT 2 -- us2k11Minor allele frequency- C:0.00WA 2
    rs1924912141,2
    --43512976(+) CCACCG/TGCCTT 2 -- us2k10--------

    HapMap Linkage Disequilibrium report for YWHAB (43514317 - 43537173 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 1 variation for YWHAB:    About this table    
    Variant IDTypeSubtypePubMed ID
    nsv518547CNV Gain19592680

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing YWHAB
    DNA2.0 Custom Variant and Variant Library Synthesis for YWHAB

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section

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    OMIM gene information: 601289    OMIM disorders: --


    Find genes that share disorders with YWHAB           About GenesLikeMe

    Genetic Association Database (GAD): YWHAB
    Human Genome Epidemiology (HuGE) Navigator: YWHAB (1 document)

    Export disorders for YWHAB gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for YWHAB gene, integrated from 10 sources (see all 252):
    (articles sorted by number of sources associating them with YWHAB)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Phosphorylation-dependent binding of 14-3-3 terminates signalling by the Gab2 docking protein. (PubMed id 19172738)1, 2 Brummer T.... Daly R.J. (EMBO J. 2008)
    2. Examination of association to autism of common genetic variationin genes related to dopamine. (PubMed id 19360691)1, 4 Anderson B.M....Haines J.L. (Autism Res 2008)
    3. Inactivation of YAP oncoprotein by the Hippo pathway is involved in cell contact inhibition and tissue growth control. (PubMed id 17974916)1, 2 Zhao B.... Guan K.L. (Genes Dev. 2007)
    4. Homodimerization of Ror2 tyrosine kinase receptor induces 14-3- 3(beta) phosphorylation and promotes osteoblast differentiation and bone formation. (PubMed id 17717073)1, 2 Liu Y.... Billiard J. (Mol. Endocrinol. 2007)
    5. Proteomic and bioinformatic characterization of the biogenesis and function of melanosomes. (PubMed id 17081065)1, 2 Chi A....Hunt D.F. (J. Proteome Res. 2006)
    6. A pathway of neuregulin-induced activation of cofilin-phosphatase Slingshot and cofilin in lamellipodia. (PubMed id 15159416)1, 2 Nagata-Ohashi K.... Mizuno K. (J. Cell Biol. 2004)
    7. The CREB coactivator TORC2 functions as a calcium- and cAMP-sensitive coincidence detector. (PubMed id 15454081)1, 2 Screaton R.A.... Montminy M. (Cell 2004)
    8. Association of a four-amino acid residue insertion polymorphism of the HS1 gene with systemic lupus erythematosus: molecular and functional analysis. (PubMed id 15022330)1, 4 Otsuka J....Harada M. (Arthritis Rheum. 2004)
    9. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    10. Exploring proteomes and analyzing protein processing by mass spectrometric identification of sorted N-terminal peptides. (PubMed id 12665801)1, 2 Gevaert K.... Vandekerckhove J. (Nat. Biotechnol. 2003)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 7529 HGNC: 12849 AceView: YWHAB Ensembl:ENSG00000166913 euGenes: HUgn7529
    ECgene: YWHAB Kegg: 7529 H-InvDB: YWHAB

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
    About This Section

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    NameDescription
    PharmGKB entry for YWHAB Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section

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    Patent Information for YWHAB gene:
    Search GeneIP for patents involving YWHAB

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, eBioscience, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
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