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Aliases for YWHAB Gene

Aliases for YWHAB Gene

  • Tyrosine 3-Monooxygenase/Tryptophan 5-Monooxygenase Activation Protein, Beta 2 3
  • Tyrosine 3-Monooxygenase/Tryptophan 5-Monooxygenase Activation Protein, Alpha Polypeptide 2 3
  • Tyrosine 3-Monooxygenase/Tryptophan 5-Monooxygenase Activation Protein, Beta Polypeptide 2 3
  • Protein Kinase C Inhibitor Protein 1 3 4
  • 14-3-3 Alpha 2 3
  • Protein 1054 3 4
  • KCIP-1 3 4
  • Protein Kinase C Inhibitor Protein-1 3
  • Brain Protein 14-3-3, Beta Isoform 3
  • Epididymis Secretory Protein Li 1 3
  • 14-3-3 Protein Beta/Alpha 3
  • 14-3-3 Beta 2
  • HEL-S-1 3
  • GW128 3
  • YWHAA 3
  • HS1 3

External Ids for YWHAB Gene

Previous Symbols for YWHAB Gene

  • YWHAA

Summaries for YWHAB Gene

Entrez Gene Summary for YWHAB Gene

  • This gene encodes a protein belonging to the 14-3-3 family of proteins, members of which mediate signal transduction by binding to phosphoserine-containing proteins. This highly conserved protein family is found in both plants and mammals. The encoded protein has been shown to interact with RAF1 and CDC25 phosphatases, suggesting that it may play a role in linking mitogenic signaling and the cell cycle machinery. Two transcript variants, which encode the same protein, have been identified for this gene. [provided by RefSeq, Jul 2008]

GeneCards Summary for YWHAB Gene

YWHAB (Tyrosine 3-Monooxygenase/Tryptophan 5-Monooxygenase Activation Protein, Beta) is a Protein Coding gene. Among its related pathways are PI3K-Akt signaling pathway and PI-3K cascade. GO annotations related to this gene include enzyme binding and protein C-terminus binding. An important paralog of this gene is YWHAZ.

UniProtKB/Swiss-Prot for YWHAB Gene

  • Adapter protein implicated in the regulation of a large spectrum of both general and specialized signaling pathways. Binds to a large number of partners, usually by recognition of a phosphoserine or phosphothreonine motif. Binding generally results in the modulation of the activity of the binding partner. Negative regulator of osteogenesis. Blocks the nuclear translocation of the phosphorylated form (by AKT1) of SRPK2 and antagonizes its stimulatory effect on cyclin D1 expression resulting in blockage of neuronal apoptosis elicited by SRPK2.

Tocris Summary for YWHAB Gene

  • 14.3.3 proteins are a group of highly conserved proteins that are involved in many vital cellular processes such as metabolism, protein trafficking, signal transduction, apoptosis and cell cycle regulation. 14.3.3 proteins are phospho-serine/phospho-threonine binding proteins that have a diverse array of partners including transcription factors, biosynthetic enzymes, cytoskeletal proteins, signalling molecules, apoptosis factors and tumour suppressors. The 14.3.3 family consists of 7 isoforms; beta, gamma, epsilon, sigma, zeta, tau and eta. 14.3.3 proteins are ubiquitously expressed and self assemble into homo- and heterodimers, with the exception of 14.3.3sigma, which exclusively forms homodimers and is found in cells of epithelial origin only. Each monomer contains an independent ligand-binding site, thus the 14.3.3 dimer can interact with two target proteins simultaneously. 14.3.3 proteins are highly rigid structures and ligand binding can induce conformational changes that alter the stability and/or catalytic activity of the ligand. Furthermore, 14.3.3 protein binding can physically occlude sequence-specific or structural motifs on the target that prevent molecular interactions and/or modulate the accessibility of a target protein to modifying enzymes such as kinases, phosphatases and proteases. In addition, 14.3.3 proteins can act as a scaffold molecule to anchor target proteins within close proximity of one another. 14.3.3 proteins represent an integration point for proliferative, survival, apoptotic and stress signalling pathways. Members of the 14.3.3 protein family enhance the activity of many proteins with proliferative and/or survival functions, such as Raf kinases, and antagonise the activity of proteins that promote cell death and senescence, such as Bad, Bim and Bax. In contrast, 14.3.3sigma acts as a tumour suppressor and its expression is upregulated coordinately with p53 and BRAC1. This isoform sequesters cdk1-cyclin B complexes in the cytoplasm, and thus delays cell cycle progression. 14.3.3sigma is also a crucial regulator of translation during mitosis. Because many 14.3.3 interactions are phosphorylation dependent, 14.3.3 proteins have been integrated into the core regulatory pathways that are crucial for normal growth and development. 14.3.3 proteins are directly involved in cellular processes such as cytokinesis, cell-contact inhibition, anchorage-independent growth and cell adhesion, and it is these pathways that often become dysregulated in disease states such as cancer.

Gene Wiki entry for YWHAB Gene

No data available for PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for YWHAB Gene

Genomics for YWHAB Gene

Genomic Location for YWHAB Gene

Start:
44,885,599 bp from pter
End:
44,908,532 bp from pter
Size:
22,934 bases
Orientation:
Plus strand

Genomic View for YWHAB Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for YWHAB Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for YWHAB Gene

Regulatory Elements for YWHAB Gene

Proteins for YWHAB Gene

  • Protein details for YWHAB Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P31946-1433B_HUMAN
    Recommended name:
    14-3-3 protein beta/alpha
    Protein Accession:
    P31946
    Secondary Accessions:
    • A8K9K2
    • E1P616

    Protein attributes for YWHAB Gene

    Size:
    246 amino acids
    Molecular mass:
    28082 Da
    Quaternary structure:
    • Homodimer. Interacts with SAMSN1 and PRKCE (By similarity). Interacts with SSH1 and TORC2/CRTC2. Interacts with ABL1; the interaction results in cytoplasmic location of ABL1 and inhibition of cABL-mediated apoptosis. Interacts with ROR2 (dimer); the interaction results in phosphorylation of YWHAB on tyrosine residues. Interacts with GAB2 and YAP1 (phosphorylated form). Interacts with the phosphorylated (by AKT1) form of SRPK2. Interacts with PKA-phosphorylated AANAT. Interacts with MYO1C and SIRT2. Interacts with herpes simplex virus 1 protein UL46.

    Three dimensional structures from OCA and Proteopedia for YWHAB Gene

    Alternative splice isoforms for YWHAB Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for YWHAB Gene

Proteomics data for YWHAB Gene at MOPED

Post-translational modifications for YWHAB Gene

  • Isoform Short contains a N-acetylmethionine at position 1.
  • The alpha, brain-specific form differs from the beta form in being phosphorylated. Phosphorylated on Ser-60 by protein kinase C delta type catalytic subunit in a sphingosine-dependent fashion.
  • Modification sites at PhosphoSitePlus
  • Ubiquitination at Lys11, Lys13, Lys51, Lys70, Lys117, Lys122, Lys124, Lys140, and Lys160

Other Protein References for YWHAB Gene

ENSEMBL proteins:
Reactome Protein details:
REFSEQ proteins:

No data available for DME Specific Peptides for YWHAB Gene

Domains for YWHAB Gene

Protein Domains for YWHAB Gene

InterPro:
Blocks:
ProtoNet:

Suggested Antigen Peptide Sequences for YWHAB Gene

Graphical View of Domain Structure for InterPro Entry

P31946

UniProtKB/Swiss-Prot:

1433B_HUMAN
Family:
  • Belongs to the 14-3-3 family.:
    • P31946
genes like me logo Genes that share domains with YWHAB: view

No data available for Gene Families for YWHAB Gene

Function for YWHAB Gene

Molecular function for YWHAB Gene

GENATLAS Biochemistry: tyrosine 3-monooxygenase/trytophan 5 monooxygenase activation protein,14-3-3 beta protein,including the phosphorylated form YWHAA (alpha),multifunctional regulator involved in cell-cyle control (checkpoint) and signal transduction,inhibitor of apoptosis through inhibiting the activation of p38 MAP kinase
UniProtKB/Swiss-Prot Function: Adapter protein implicated in the regulation of a large spectrum of both general and specialized signaling pathways. Binds to a large number of partners, usually by recognition of a phosphoserine or phosphothreonine motif. Binding generally results in the modulation of the activity of the binding partner. Negative regulator of osteogenesis. Blocks the nuclear translocation of the phosphorylated form (by AKT1) of SRPK2 and antagonizes its stimulatory effect on cyclin D1 expression resulting in blockage of neuronal apoptosis elicited by SRPK2.

Gene Ontology (GO) - Molecular Function for YWHAB Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003714 transcription corepressor activity IEA --
GO:0005515 protein binding IPI 10713667
GO:0008022 protein C-terminus binding IEA --
GO:0019899 enzyme binding IPI 17255105
GO:0019904 protein domain specific binding IPI 11984006
genes like me logo Genes that share ontologies with YWHAB: view

miRNA for YWHAB Gene

No data available for Enzyme Numbers (IUBMB) , Phenotypes , Animal Models , Transcription Factor Targeting and HOMER Transcription for YWHAB Gene

Localization for YWHAB Gene

Subcellular locations from UniProtKB/Swiss-Prot for YWHAB Gene

Cytoplasm. Melanosome. Note=Identified by mass spectrometry in melanosome fractions from stage I to stage IV.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for YWHAB Gene COMPARTMENTS Subcellular localization image for YWHAB gene
Compartment Confidence
cytosol 4
cytoskeleton 3
nucleus 3
golgi apparatus 1

Gene Ontology (GO) - Cellular Components for YWHAB Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IEA --
GO:0005737 cytoplasm IDA --
GO:0005829 cytosol TAS --
GO:0005925 focal adhesion IDA 21423176
GO:0016020 membrane IDA 19946888
genes like me logo Genes that share ontologies with YWHAB: view

Pathways for YWHAB Gene

SuperPathways for YWHAB Gene

genes like me logo Genes that share pathways with YWHAB: view

Gene Ontology (GO) - Biological Process for YWHAB Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000165 MAPK cascade TAS --
GO:0000186 activation of MAPKK activity TAS --
GO:0006367 transcription initiation from RNA polymerase II promoter TAS --
GO:0006605 protein targeting IEA --
GO:0006915 apoptotic process TAS --
genes like me logo Genes that share ontologies with YWHAB: view

Compounds for YWHAB Gene

(2) Tocris Compounds for YWHAB Gene

Compound Action Cas Number
Difopein High affinity inhibitor of 14.3.3 proteins; induces apoptosis [396834-58-5]
R18 Inhibitor of 14.3.3 proteins; induces apoptosis [211364-78-2]

(2) HMDB Compounds for YWHAB Gene

Compound Synonyms Cas Number PubMed IDs
Sepiapterin
  • L-sepiapterin
17094-01-8
Zolpidem
  • Ambien
82626-48-0

(1) Novoseek inferred chemical compound relationships for YWHAB Gene

Compound -log(P) Hits PubMed IDs
serine 28.2 1
genes like me logo Genes that share compounds with YWHAB: view

Transcripts for YWHAB Gene

Unigene Clusters for YWHAB Gene

Tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, beta polypeptide:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for YWHAB Gene

ExUns: 1a · 1b ^ 2 ^ 3a · 3b ^ 4a · 4b · 4c · 4d ^ 5a · 5b · 5c ^ 6a · 6b ^ 7a · 7b ^ 8 ^ 9a · 9b · 9c
SP1: - - - - - -
SP2: - - - - - - -
SP3:
SP4: -
SP5: -
SP6:
SP7: - - - - - -
SP8: - - - - - -
SP9: -
SP10: - - -

Relevant External Links for YWHAB Gene

GeneLoc Exon Structure for
YWHAB
ECgene alternative splicing isoforms for
YWHAB

Expression for YWHAB Gene

mRNA expression in normal human tissues for YWHAB Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for YWHAB Gene

SOURCE GeneReport for Unigene cluster for YWHAB Gene Hs.643544

genes like me logo Genes that share expressions with YWHAB: view

No data available for mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for YWHAB Gene

Orthologs for YWHAB Gene

This gene was present in the common ancestor of animals.

Orthologs for YWHAB Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia YWHAB 35
  • 99.73 (n)
  • 100 (a)
YWHAB 36
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia YWHAB 35
  • 92.01 (n)
  • 100 (a)
YWHAB 36
  • 100 (a)
OneToOne
dog
(Canis familiaris)
Mammalia YWHAB 35
  • 93.72 (n)
  • 100 (a)
YWHAB 36
  • 100 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Ywhab 35
  • 90.65 (n)
  • 98.78 (a)
Ywhab 16
Ywhab 36
  • 99 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia YWHAB 36
  • 92 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia YWHAB 36
  • 83 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Ywhab 35
  • 91.33 (n)
  • 98.37 (a)
chicken
(Gallus gallus)
Aves YWHAB 35
  • 84.7 (n)
  • 97.95 (a)
YWHAB 36
  • 98 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia YWHAB 36
  • 97 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia ywhab 35
  • 79.23 (n)
  • 88.52 (a)
zebrafish
(Danio rerio)
Actinopterygii -- 35
ywhaba 35
  • 80.05 (n)
  • 91.39 (a)
ywhaba 36
  • 91 (a)
OneToMany
ywhabb 36
  • 89 (a)
OneToMany
fruit fly
(Drosophila melanogaster)
Insecta 14-3-3zeta 36
  • 78 (a)
OneToMany
14-3-3zgr 37
  • 79 (a)
worm
(Caenorhabditis elegans)
Secernentea ftt-2 36
  • 77 (a)
ManyToMany
par-5 36
  • 75 (a)
ManyToMany
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.4900 35
Species with no ortholog for YWHAB:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for YWHAB Gene

ENSEMBL:
Gene Tree for YWHAB (if available)
TreeFam:
Gene Tree for YWHAB (if available)

Paralogs for YWHAB Gene

Paralogs for YWHAB Gene

Selected SIMAP similar genes for YWHAB Gene using alignment to 4 proteins:

Pseudogenes.org Pseudogenes for YWHAB Gene

genes like me logo Genes that share paralogs with YWHAB: view

Variants for YWHAB Gene

Sequence variations from dbSNP and Humsavar for YWHAB Gene

SNP ID Clin Chr 20 pos Sequence Context AA Info Type MAF
rs4931 -- 44,901,593(+) GAGCG(A/C/G/T)TATGA reference, synonymous-codon
rs6876 -- 44,906,460(+) TGATC(C/T)GTTCA utr-variant-3-prime
rs8356 -- 44,907,814(+) CAACA(C/T)GGTGT utr-variant-3-prime
rs8787 -- 44,907,618(+) CTCTT(C/T)TAAGT utr-variant-3-prime
rs13449 -- 44,908,051(-) TGATT(C/T)TGTGA utr-variant-3-prime

Structural Variations from Database of Genomic Variants (DGV) for YWHAB Gene

Variant ID Type Subtype PubMed ID
nsv518547 CNV Gain 19592680

Relevant External Links for YWHAB Gene

HapMap Linkage Disequilibrium report
YWHAB

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for YWHAB Gene

Disorders for YWHAB Gene

Relevant External Links for YWHAB

Genetic Association Database (GAD)
YWHAB
Human Genome Epidemiology (HuGE) Navigator
YWHAB
genes like me logo Genes that share disorders with YWHAB: view

No data available for UniProtKB/Swiss-Prot for YWHAB Gene

Publications for YWHAB Gene

  1. Molecular cloning and expression of the transformation sensitive epithelial marker stratifin. A member of a protein family that has been involved in the protein kinase C signalling pathway. (PMID: 8515476) Leffers H. … Celis J.E. (J. Mol. Biol. 1993) 3 4
  2. Assignment of the human genes encoding 14,3-3 Eta (YWHAH) to 22q12, 14-3-3 zeta (YWHAZ) to 2p25.1-p25.2, and 14-3-3 beta (YWHAB) to 20q13.1 by in situ hybridization. (PMID: 8617504) Tommerup N. … Leffers H. (Genomics 1996) 2 3
  3. The DNA sequence and comparative analysis of human chromosome 20. (PMID: 11780052) Deloukas P. … Rogers J. (Nature 2001) 3 4
  4. Exploring proteomes and analyzing protein processing by mass spectrometric identification of sorted N-terminal peptides. (PMID: 12665801) Gevaert K. … Vandekerckhove J. (Nat. Biotechnol. 2003) 3 4
  5. Association of a four-amino acid residue insertion polymorphism of the HS1 gene with systemic lupus erythematosus: molecular and functional analysis. (PMID: 15022330) Otsuka J. … Harada M. (Arthritis Rheum. 2004) 3 48

Products for YWHAB Gene

  • Addgene plasmids for YWHAB

Sources for YWHAB Gene

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