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Aliases for YWHAB Gene

Aliases for YWHAB Gene

  • Tyrosine 3-Monooxygenase/Tryptophan 5-Monooxygenase Activation Protein Beta 2 3
  • Tyrosine 3-Monooxygenase/Tryptophan 5-Monooxygenase Activation Protein, Alpha Polypeptide 2 3
  • Tyrosine 3-Monooxygenase/Tryptophan 5-Monooxygenase Activation Protein, Beta Polypeptide 2 3
  • Protein Kinase C Inhibitor Protein 1 3 4
  • 14-3-3 Alpha 2 3
  • Protein 1054 3 4
  • KCIP-1 3 4
  • Tyrosine 3-Monooxygenase/Tryptophan 5-Monooxygenase Activation Protein, Beta 5
  • Protein Kinase C Inhibitor Protein-1 3
  • Brain Protein 14-3-3, Beta Isoform 3
  • Epididymis Secretory Protein Li 1 3
  • 14-3-3 Beta 2
  • HEL-S-1 3
  • GW128 3
  • YWHAA 3
  • HS1 3

External Ids for YWHAB Gene

Previous HGNC Symbols for YWHAB Gene

  • YWHAA

Previous GeneCards Identifiers for YWHAB Gene

  • GC20P043242
  • GC20P043202
  • GC20P044152
  • GC20P044199
  • GC20P042947
  • GC20P043515
  • GC20P040256

Summaries for YWHAB Gene

Entrez Gene Summary for YWHAB Gene

  • This gene encodes a protein belonging to the 14-3-3 family of proteins, members of which mediate signal transduction by binding to phosphoserine-containing proteins. This highly conserved protein family is found in both plants and mammals. The encoded protein has been shown to interact with RAF1 and CDC25 phosphatases, suggesting that it may play a role in linking mitogenic signaling and the cell cycle machinery. Two transcript variants, which encode the same protein, have been identified for this gene. [provided by RefSeq, Jul 2008]

GeneCards Summary for YWHAB Gene

YWHAB (Tyrosine 3-Monooxygenase/Tryptophan 5-Monooxygenase Activation Protein Beta) is a Protein Coding gene. Diseases associated with YWHAB include creutzfeldt-jakob disease and gerstmann-straussler disease. Among its related pathways are Gene Expression and Signaling by GPCR. GO annotations related to this gene include enzyme binding and protein complex binding. An important paralog of this gene is YWHAH.

UniProtKB/Swiss-Prot for YWHAB Gene

  • Adapter protein implicated in the regulation of a large spectrum of both general and specialized signaling pathways. Binds to a large number of partners, usually by recognition of a phosphoserine or phosphothreonine motif. Binding generally results in the modulation of the activity of the binding partner. Negative regulator of osteogenesis. Blocks the nuclear translocation of the phosphorylated form (by AKT1) of SRPK2 and antagonizes its stimulatory effect on cyclin D1 expression resulting in blockage of neuronal apoptosis elicited by SRPK2.

Tocris Summary for YWHAB Gene

  • 14.3.3 proteins are a group of highly conserved proteins that are involved in many vital cellular processes such as metabolism, protein trafficking, signal transduction, apoptosis and cell cycle regulation. 14.3.3 proteins are phospho-serine/-threonine binding proteins.

Gene Wiki entry for YWHAB Gene

No data available for PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for YWHAB Gene

Genomics for YWHAB Gene

Regulatory Elements for YWHAB Gene

Promoters for YWHAB Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around YWHAB on UCSC Golden Path with GeneCards custom track

Genomic Location for YWHAB Gene

Chromosome:
20
Start:
44,885,599 bp from pter
End:
44,908,532 bp from pter
Size:
22,934 bases
Orientation:
Plus strand

Genomic View for YWHAB Gene

Genes around YWHAB on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
YWHAB Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for YWHAB Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for YWHAB Gene

Proteins for YWHAB Gene

  • Protein details for YWHAB Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P31946-1433B_HUMAN
    Recommended name:
    14-3-3 protein beta/alpha
    Protein Accession:
    P31946
    Secondary Accessions:
    • A8K9K2
    • E1P616

    Protein attributes for YWHAB Gene

    Size:
    246 amino acids
    Molecular mass:
    28082 Da
    Quaternary structure:
    • Homodimer. Interacts with SAMSN1 and PRKCE (By similarity). Interacts with SSH1 and TORC2/CRTC2. Interacts with ABL1; the interaction results in cytoplasmic location of ABL1 and inhibition of cABL-mediated apoptosis. Interacts with ROR2 (dimer); the interaction results in phosphorylation of YWHAB on tyrosine residues. Interacts with GAB2 and YAP1 (phosphorylated form). Interacts with the phosphorylated (by AKT1) form of SRPK2. Interacts with PKA-phosphorylated AANAT. Interacts with MYO1C and SIRT2. Interacts with herpes simplex virus 1 protein UL46. Interacts with the Thr-369 phosphorylated form of DAPK2 (PubMed:26047703).

    Three dimensional structures from OCA and Proteopedia for YWHAB Gene

    Alternative splice isoforms for YWHAB Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for YWHAB Gene

Proteomics data for YWHAB Gene at MOPED

Post-translational modifications for YWHAB Gene

  • Isoform Short contains a N-acetylmethionine at position 1.
  • The alpha, brain-specific form differs from the beta form in being phosphorylated. Phosphorylated on Ser-60 by protein kinase C delta type catalytic subunit in a sphingosine-dependent fashion.
  • Ubiquitination at Lys 11, Lys 117, and Lys 140
  • Modification sites at PhosphoSitePlus

Other Protein References for YWHAB Gene

Antibody Products

  • Cell Signaling Technology (CST) Antibodies for YWHAB (14-3-3 beta)

No data available for DME Specific Peptides for YWHAB Gene

Domains & Families for YWHAB Gene

Protein Domains for YWHAB Gene

InterPro:
Blocks:
ProtoNet:

Suggested Antigen Peptide Sequences for YWHAB Gene

Graphical View of Domain Structure for InterPro Entry

P31946

UniProtKB/Swiss-Prot:

1433B_HUMAN :
  • Belongs to the 14-3-3 family.
Family:
  • Belongs to the 14-3-3 family.
genes like me logo Genes that share domains with YWHAB: view

Function for YWHAB Gene

Molecular function for YWHAB Gene

GENATLAS Biochemistry:
tyrosine 3-monooxygenase/trytophan 5 monooxygenase activation protein,14-3-3 beta protein,including the phosphorylated form YWHAA (alpha),multifunctional regulator involved in cell-cyle control (checkpoint) and signal transduction,inhibitor of apoptosis through inhibiting the activation of p38 MAP kinase
UniProtKB/Swiss-Prot Function:
Adapter protein implicated in the regulation of a large spectrum of both general and specialized signaling pathways. Binds to a large number of partners, usually by recognition of a phosphoserine or phosphothreonine motif. Binding generally results in the modulation of the activity of the binding partner. Negative regulator of osteogenesis. Blocks the nuclear translocation of the phosphorylated form (by AKT1) of SRPK2 and antagonizes its stimulatory effect on cyclin D1 expression resulting in blockage of neuronal apoptosis elicited by SRPK2.
genes like me logo Genes that share phenotypes with YWHAB: view

Animal Model Products

  • Taconic Biosciences Mouse Models for YWHAB

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for YWHAB Gene

Localization for YWHAB Gene

Subcellular locations from UniProtKB/Swiss-Prot for YWHAB Gene

Cytoplasm. Melanosome. Note=Identified by mass spectrometry in melanosome fractions from stage I to stage IV.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for YWHAB Gene COMPARTMENTS Subcellular localization image for YWHAB gene
Compartment Confidence
cytosol 5
extracellular 5
mitochondrion 4
nucleus 4
cytoskeleton 1
endoplasmic reticulum 1
golgi apparatus 1
plasma membrane 1

Gene Ontology (GO) - Cellular Components for YWHAB Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm IEA,IDA 10869435
GO:0030659 cytoplasmic vesicle membrane TAS --
GO:0042470 melanosome IEA --
genes like me logo Genes that share ontologies with YWHAB: view

Pathways & Interactions for YWHAB Gene

SuperPathways for YWHAB Gene

Superpath Contained pathways
1 Interleukin-3, 5 and GM-CSF signaling
2 Activation of cAMP-Dependent PKA
3 mTOR signalling
4 Immune System
5 CDK-mediated phosphorylation and removal of Cdc6
genes like me logo Genes that share pathways with YWHAB: view

SIGNOR curated interactions for YWHAB Gene

Inactivates:
Is inactivated by:

Gene Ontology (GO) - Biological Process for YWHAB Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000186 activation of MAPKK activity TAS --
GO:0006367 transcription initiation from RNA polymerase II promoter TAS --
GO:0006915 apoptotic process TAS --
GO:0007173 epidermal growth factor receptor signaling pathway TAS --
GO:0007411 axon guidance TAS --
genes like me logo Genes that share ontologies with YWHAB: view

Drugs & Compounds for YWHAB Gene

(2) Drugs for YWHAB Gene - From: HMDB and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Zolpidem Approved Pharma Full agonist, Allosteric regulator 94

(3) Additional Compounds for YWHAB Gene - From: Tocris and HMDB

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
Sepiapterin
  • (S)-2-amino-7,8-dihydro-6-(2-hydroxy-1-oxopropyl)-4(1H)-Pteridinone
  • 1-(2-Amino-7,8-dihydro-4-hydroxy-6-pteridinyl)-2-hydroxy-1-Propanone
  • 2-Amino-6-(S)-lactoyl-7,8-dihydro-4(3H)-pteridinone
  • 2-Amino-7,8-dihydro-6-[(2S)-2-hydroxy-1-oxopropyl]-4(1H)Pteridinone
  • L-Sepiapterin
17094-01-8
Difopein
396834-58-5
R18
211364-78-2

(2) Tocris Compounds for YWHAB Gene

Compound Action Cas Number
Difopein High affinity inhibitor of 14.3.3 proteins; induces apoptosis 396834-58-5
R18 Inhibitor of 14.3.3 proteins 211364-78-2
genes like me logo Genes that share compounds with YWHAB: view

Transcripts for YWHAB Gene

Unigene Clusters for YWHAB Gene

Tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, beta polypeptide:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for YWHAB Gene

ExUns: 1a · 1b ^ 2 ^ 3a · 3b ^ 4a · 4b · 4c · 4d ^ 5a · 5b · 5c ^ 6a · 6b ^ 7a · 7b ^ 8 ^ 9a · 9b · 9c
SP1: - - - - - -
SP2: - - - - - - -
SP3:
SP4: -
SP5: -
SP6:
SP7: - - - - - -
SP8: - - - - - -
SP9: -
SP10: - - -

Relevant External Links for YWHAB Gene

GeneLoc Exon Structure for
YWHAB
ECgene alternative splicing isoforms for
YWHAB

Expression for YWHAB Gene

mRNA expression in normal human tissues for YWHAB Gene

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for YWHAB Gene



SOURCE GeneReport for Unigene cluster for YWHAB Gene Hs.643544

genes like me logo Genes that share expression patterns with YWHAB: view

Protein tissue co-expression partners for YWHAB Gene

- Elite partner

Primer Products

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for YWHAB Gene

Orthologs for YWHAB Gene

This gene was present in the common ancestor of animals.

Orthologs for YWHAB Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia YWHAB 35
  • 92.01 (n)
  • 100 (a)
YWHAB 36
  • 100 (a)
OneToOne
dog
(Canis familiaris)
Mammalia YWHAB 35
  • 93.72 (n)
  • 100 (a)
YWHAB 36
  • 100 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Ywhab 35
  • 90.65 (n)
  • 98.78 (a)
Ywhab 16
Ywhab 36
  • 99 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia YWHAB 35
  • 99.73 (n)
  • 100 (a)
YWHAB 36
  • 100 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Ywhab 35
  • 91.33 (n)
  • 98.37 (a)
oppossum
(Monodelphis domestica)
Mammalia YWHAB 36
  • 92 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia YWHAB 36
  • 83 (a)
OneToOne
chicken
(Gallus gallus)
Aves YWHAB 35
  • 84.7 (n)
  • 97.95 (a)
YWHAB 36
  • 98 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia YWHAB 36
  • 97 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia ywhab 35
  • 79.23 (n)
  • 88.52 (a)
zebrafish
(Danio rerio)
Actinopterygii -- 35
ywhaba 35
  • 80.05 (n)
  • 91.39 (a)
ywhaba 36
  • 91 (a)
OneToMany
ywhabb 36
  • 89 (a)
OneToMany
fruit fly
(Drosophila melanogaster)
Insecta 14-3-3zgr 37
  • 79 (a)
14-3-3zeta 36
  • 78 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea ftt-2 36
  • 77 (a)
ManyToMany
par-5 36
  • 75 (a)
ManyToMany
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.4900 35
Species with no ortholog for YWHAB:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for YWHAB Gene

ENSEMBL:
Gene Tree for YWHAB (if available)
TreeFam:
Gene Tree for YWHAB (if available)

Paralogs for YWHAB Gene

Paralogs for YWHAB Gene

Pseudogenes.org Pseudogenes for YWHAB Gene

genes like me logo Genes that share paralogs with YWHAB: view

Variants for YWHAB Gene

Sequence variations from dbSNP and Humsavar for YWHAB Gene

SNP ID Clin Chr 20 pos Sequence Context AA Info Type
VAR_064762 -
rs4931 -- 44,901,593(+) GAGCG(A/C/G/T)TATGA reference, synonymous-codon
rs6876 -- 44,906,460(+) TGATC(C/T)GTTCA utr-variant-3-prime
rs8356 -- 44,907,814(+) CAACA(C/T)GGTGT utr-variant-3-prime
rs8787 -- 44,907,618(+) CTCTT(C/T)TAAGT utr-variant-3-prime

Structural Variations from Database of Genomic Variants (DGV) for YWHAB Gene

Variant ID Type Subtype PubMed ID
nsv518547 CNV Gain 19592680

Variation tolerance for YWHAB Gene

Residual Variation Intolerance Score: 35.3% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.64; 13.61% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for YWHAB Gene

HapMap Linkage Disequilibrium report
YWHAB

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for YWHAB Gene

Disorders for YWHAB Gene

MalaCards: The human disease database

(2) MalaCards diseases for YWHAB Gene - From: DISEASES and GeneCards

Disorder Aliases PubMed IDs
creutzfeldt-jakob disease
  • creutzfeldt-jakob disease, variant
gerstmann-straussler disease
  • cerebral amyloid angiopathy, prnp-related
- elite association - COSMIC cancer census association via MalaCards
Search YWHAB in MalaCards View complete list of genes associated with diseases

Relevant External Links for YWHAB

Genetic Association Database (GAD)
YWHAB
Human Genome Epidemiology (HuGE) Navigator
YWHAB
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
YWHAB
genes like me logo Genes that share disorders with YWHAB: view

No data available for UniProtKB/Swiss-Prot and Genatlas for YWHAB Gene

Publications for YWHAB Gene

  1. Crystal structure of human myosin 1c - the motor in GLUT4 exocytosis: implications for Ca(2+)-regulation and 14-3-3 binding. (PMID: 24636949) Stefan Munnich M.H. … Manstein D.J. (J. Mol. Biol. 2014) 3 4 67
  2. Assignment of the human genes encoding 14,3-3 Eta (YWHAH) to 22q12, 14-3-3 zeta (YWHAZ) to 2p25.1-p25.2, and 14-3-3 beta (YWHAB) to 20q13.1 by in situ hybridization. (PMID: 8617504) Tommerup N. … Leffers H. (Genomics 1996) 2 3
  3. 14-3-3 alpha and delta are the phosphorylated forms of raf-activating 14-3-3 beta and zeta. In vivo stoichiometric phosphorylation in brain at a Ser-Pro-Glu-Lys MOTIF. (PMID: 7890696) Aitken A. … Patel Y. (J. Biol. Chem. 1995) 2 3
  4. In silico prediction of physical protein interactions and characterization of interactome orphans. (PMID: 25402006) Kotlyar M. … Jurisica I. (Nat. Methods 2015) 3
  5. Control of a neuronal morphology program by an RNA-binding zinc finger protein, Unkempt. (PMID: 25737280) Murn J. … Shi Y. (Genes Dev. 2015) 3

Products for YWHAB Gene

Sources for YWHAB Gene

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