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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

YWHAB Gene

protein-coding   GIFtS: 67
GCID: GC20P043515

tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation...

(Previous names: tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation...)
(Previous symbol: YWHAA)
 Explore 23 diseases affiliated with
YWHAB via
MalaCards
our new
 Human Malady Compendium 
Biological research products
for YWHAB    

Aliases
for YWHAB gene

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, and/or 10fRNAdb)
About This Section
Aliases
Tyrosine 3-Monooxygenase/Tryptophan 5-Monooxygenase Activation Protein, Beta
Polypeptide1 2
     14-3-3 Alpha2
YWHAA1 2     14-3-3 Protein Beta/Alpha2
Tyrosine 3-Monooxygenase/Tryptophan 5-Monooxygenase Activation Protein, Alpha
Polypeptide1 2
     GW1282
Protein 10542 3     HS12
Protein Kinase C Inhibitor Protein 12 3     Brain Protein 14-3-3, Beta Isoform2
KCIP-12 3     Protein Kinase C Inhibitor Protein-12

External Ids:    HGNC: 128491   Entrez Gene: 75292   Ensembl: ENSG000001669137   OMIM: 6012895   UniProtKB: P319463   

Export aliases for YWHAB gene to outside databases

Previous GC identifers: GC20P043242 GC20P043202 GC20P044152 GC20P044199 GC20P042947 GC20P040256


Summaries
for YWHAB gene

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section
Entrez Gene summary for YWHAB:
This gene encodes a protein belonging to the 14-3-3 family of proteins, members of which mediate signal transduction by
binding to phosphoserine-containing proteins. This highly conserved protein family is found in both plants and
mammals. The encoded protein has been shown to interact with RAF1 and CDC25 phosphatases, suggesting that it may play
a role in linking mitogenic signaling and the cell cycle machinery. Two transcript variants, which encode the same
protein, have been identified for this gene. (provided by RefSeq, Jul 2008)

UniProtKB/Swiss-Prot: 1433B_HUMAN, P31946
Function: Adapter protein implicated in the regulation of a large spectrum of both general and specialized signaling
pathways. Binds to a large number of partners, usually by recognition of a phosphoserine or phosphothreonine motif.
Binding generally results in the modulation of the activity of the binding partner. Negative regulator of
osteogenesis. Blocks the nuclear translocation of the phosphorylated form (by AKT1) of SRPK2 and antagonizes its
stimulatory effect on cyclin D1 expression resulting in blockage of neuronal apoptosis elicited by SRPK2

summary for YWHAB:
14.3.3 proteins are a group of highly conserved proteins that are involved in many vital cellular processes
such as metabolism, protein trafficking, signal transduction, apoptosis and cell cycle regulation. 14.3.3
proteins are phospho-serine/phospho-threonine binding proteins that have a diverse array of partners
including transcription factors, biosynthetic enzymes, cytoskeletal proteins, signalling molecules,
apoptosis factors and tumour suppressors. The 14.3.3 family consists of 7 isoforms; beta, gamma, epsilon,
sigma, zeta, tau and eta. 14.3.3 proteins are ubiquitously expressed and self assemble into homo- and
heterodimers, with the exception of 14.3.3sigma, which exclusively forms homodimers and is found in cells of
epithelial origin only. Each monomer contains an independent ligand-binding site, thus the 14.3.3 dimer can
interact with two target proteins simultaneously. 14.3.3 proteins are highly rigid structures and ligand
binding can induce conformational changes that alter the stability and/or catalytic activity of the ligand.
Furthermore, 14.3.3 protein binding can physically occlude sequence-specific or structural motifs on the
target that prevent molecular interactions and/or modulate the accessibility of a target protein to
modifying enzymes such as kinases, phosphatases and proteases. In addition, 14.3.3 proteins can act as a
scaffold molecule to anchor target proteins within close proximity of one another. 14.3.3 proteins represent
an integration point for proliferative, survival, apoptotic and stress signalling pathways. Members of the
14.3.3 protein family enhance the activity of many proteins with proliferative and/or survival functions,
such as Raf kinases, and antagonise the activity of proteins that promote cell death and senescence, such as
Bad, Bim and Bax. In contrast, 14.3.3sigma acts as a tumour suppressor and its expression is upregulated
coordinately with p53 and BRAC1. This isoform sequesters cdk1-cyclin B complexes in the cytoplasm, and thus
delays cell cycle progression. 14.3.3sigma is also a crucial regulator of translation during mitosis.
Because many 14.3.3 interactions are phosphorylation dependent, 14.3.3 proteins have been integrated into
the core regulatory pathways that are crucial for normal growth and development. 14.3.3 proteins are
directly involved in cellular processes such as cytokinesis, cell-contact inhibition, anchorage-independent
growth and cell adhesion, and it is these pathways that often become dysregulated in disease states such as
cancer.

Gene Wiki entry for YWHAB


Genomic Views
for YWHAB gene

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000020.10  NC_018931.1  NT_011362.10  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the YWHAB gene promoter:
         MEF-2   E47   CREB   MEF-2A   POU2F1   FOXJ2 (long isoform)   POU2F1a   Hand1   FOXJ2   aMEF-2   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: YWHAB promoter sequence
   Search SABiosciences Chromatin IP Primers for YWHAB

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat YWHAB


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 20q13.1   Ensembl cytogenetic band:  20q13.12   HGNC cytogenetic band: 20q13.1

YWHAB Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
YWHAB gene location

GeneLoc information about chromosome 20         GeneLoc Exon Structure

GeneLoc location for GC20P043515:  view genomic region     (about GC identifiers)

Start:
 43,514,317 bp from pter      End:
 43,537,173 bp from pter
Size:
 22,857 bases      Orientation:
 plus strand

Proteins
for YWHAB gene

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section
UniProtKB/Swiss-Prot: 1433B_HUMAN, P31946 (See protein sequence)
Recommended Name: 14-3-3 protein beta/alpha  
Size: 246 amino acids; 28082 Da
Subunit: Homodimer. Interacts with SAMSN1 and KRPCE (By similarity). Interacts with SSH1 and TORC2/CRTC2. Interacts
with ABL1; the interaction results in cytoplasmic location of ABL1 and inhibition of cABL-mediated apoptosis.
Interacts with ROR2 (dimer); the interaction results in phosphorylation of YWHAB on tyrosine residues. Interacts with
GAB2 and YAP1 (phosphorylated form). Interacts with the phosphorylated (by AKT1) form of SRPK2. Interacts with
PKA-phosphorylated AANAT
Subcellular location: Cytoplasm. Melanosome. Note=Identified by mass spectrometry in melanosome fractions from stage I
to stage IV
3 PDB 3D structures from and Proteopedia for YWHAB:
2BQ0 (3D)        2C23 (3D)        4DNK (3D)    
Secondary accessions: A8K9K2 E1P616
Alternative initiation: 2 isoforms:  P31946-1   P31946-2   (Contains a N-acetylmethionine at position 1 (By similarity))

Explore the universe of human proteins at neXtProt for YWHAB: NX_P31946

Post-translational modifications:

  • The alpha, brain-specific form differs from the beta form in being phosphorylated (By similarity). Phosphorylated on
    • Ser-60 by protein kinase C delta type catalytic subunit in a sphingosine-dependent fashion (By similarity)1
  • Isoform Short contains a N-acetylmethionine at position 1 (By similarity)1
  • View modification sites using PhosphoSitePlus2
  • View neXtProt modification sites for NX_P31946

    • YWHAB Protein expression data from MOPED and PaxDb:    About this image 
    YWHAB Protein Expression
    REFSEQ proteins (2 alternative transcripts): 
    NP_003395.1  NP_647539.1  

    ENSEMBL proteins: 
     ENSP00000300161   ENSP00000361930   ENSP00000394729   ENSP00000394558  
    Reactome Protein details: P31946
    Human Recombinant Protein Products for YWHAB: 
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    Novus Biologicals YWHAB Proteins
    Novus Biologicals YWHAB Lysates
    Sino Biological Recombinant Protein for YWHAB
    ProSpec Recombinant Protein for YWHAB
    Browse Proteins at Uscn

    Gene Ontology (GO): 5/8 cellular component terms (GO ID links to tree view) (see all 8):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus ----
    GO:0005737cytoplasm IDA--
    GO:0005813centrosome ----
    GO:0005829cytosol TAS--
    GO:0017053transcriptional repressor complex IEA--

    YWHAB for ontologies           About GeneDecksing



    YWHAB Antibody Products: 
    EMD Millipore Mono- and Polyclonal Antibodies for the study of YWHAB
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    Protein Domains /
    Families
    for YWHAB gene

    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    YWHAB for domains           About GeneDecksing

    3 InterPro domains/families:
     IPR023410 14-3-3_domain
     IPR000308 14-3-3
     IPR023409 14-3-3_CS

    Graphical View of Domain Structure for InterPro Entry P31946

    ProtoNet protein and cluster: P31946

    1 Blocks protein family: IPB000308 14-3-3 protein

    UniProtKB/Swiss-Prot: 1433B_HUMAN, P31946
    Similarity: Belongs to the 14-3-3 family


    Function
    for YWHAB gene

    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, Sirion Biotech, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, Sirion Biotech, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
    About This Section
    Molecular Function:

         UniProtKB/Swiss-Prot Summary: 1433B_HUMAN, P31946
    Function: Adapter protein implicated in the regulation of a large spectrum of both general and specialized signaling
    pathways. Binds to a large number of partners, usually by recognition of a phosphoserine or phosphothreonine motif.
    Binding generally results in the modulation of the activity of the binding partner. Negative regulator of
    osteogenesis. Blocks the nuclear translocation of the phosphorylated form (by AKT1) of SRPK2 and antagonizes its
    stimulatory effect on cyclin D1 expression resulting in blockage of neuronal apoptosis elicited by SRPK2

         Genatlas biochemistry entry for YWHAB:
    tyrosine 3-monooxygenase/trytophan 5 monooxygenase activation protein,14-3-3 beta protein,including the phosphorylated
    form YWHAA (alpha),multifunctional regulator involved in cell-cyle control (checkpoint) and signal
    transduction,inhibitor of apoptosis through inhibiting the activation of p38 MAP kinase

         Gene Ontology (GO): 5/10 molecular function terms (GO ID links to tree view) (see all 10):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003714transcription corepressor activity IEA--
    GO:0004497monooxygenase activity ----
    GO:0005515protein binding IPI--
    GO:0008022protein C-terminus binding IEA--
    GO:0019899enzyme binding IPI17255105
         
    YWHAB for ontologies           About GeneDecksing


    Animal Models:
       inGenious Targeting Laboratory - Customizable classic, inducible, and humanized mouse model solutions for YWHAB 

    miRNA
    Products:            		 OriGene 3'-UTR Clone (see all 2): YWHAB
    Browse MicroRNA Expression Plasmids
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat YWHAB
    8/42 QIAGEN miScript miRNA Assays for microRNAs that regulate YWHAB (see all 42):
    hsa-miR-124* hsa-miR-4291 hsa-miR-429 hsa-miR-128 hsa-miR-759 hsa-miR-183* hsa-miR-1276 hsa-miR-200b
    SwitchGear 3'UTR luciferase reporter plasmid: YWHAB 3' UTR sequence
    Inhib. RNA
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    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for YWHAB (see all 7)
    OriGene shRNA RFP: YWHAB
    OriGene siRNA: YWHAB
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat YWHAB
    Sirion Biotech Custom design and validation of potent shRNA sequences against YWHAB 

    Gene Editing
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    Sirion Biotech Customized adenovirus for overexpression of YWHAB 
    Sirion Biotech Customized adenovirus for potent knockdown of YWHAB

    Clone
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    OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for YWHAB (see all 4)
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    GenScript: all cDNA clones in your preferred vector (see all 2): YWHAB (NM_139323)
    Sino Biological Human cDNA Clone for YWHAB
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    Cell Line
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    In Situ Assay
    Products:       
         		Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for YWHAB


    Pathways & Interactions
    for YWHAB gene

    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
    About This Section

    Unified GeneCards pathways - 5/72 super-pathways (see all 72) About this table 
    See pathways by source

    Super-pathwaycontained gene-specific pathways
    1Signaling by FGFR
    8/12 pathways (see all 12)
    		Signaling by FGFR1.00
    		DAP12 signaling0.83
    		Downstream signaling of activated FGFR0.92
    		Signaling by EGFR in Cancer0.83
    		Signaling by FGFR in disease0.91
    		DAP12 interactions0.76
    		Signaling by ERBB20.89
    		Signaling by PDGF0.72
    2SHC-mediated signalling
    8/10 pathways (see all 10)
    		SHC-mediated signalling1.00
    		GRB2 events in EGFR signaling0.71
    		SHC-related events0.88
    		RAF/MAP kinase cascade0.67
    		SHC-related events triggered by IGF1R0.83
    		RAF phosphorylates MEK0.47
    		SHC1 events in EGFR signaling0.76
    		MEK activation0.47
    3IRS-related events
    		IRS-related events1.00
    		Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R)0.90
    		IRS-mediated signalling0.98
    		IGF1R signaling cascade0.90
    		Insulin receptor signalling cascade0.94
    		Signaling by Insulin receptor0.74
    		IRS-related events triggered by IGF1R0.93
    4ARMS-mediated activation
    		ARMS-mediated activation1.00
    		Signalling to p38 via RIT and RIN0.72
    		Prolonged ERK activation events0.80
    		Frs2-mediated activation0.70
    5Activation of cAMP-Dependent PKA
    		Activation of cAMP-Dependent PKA1.00
    		Activation of PKA through GPCR0.71
    		cAMP Pathway0.77
    		PKA Signaling0.56

    Pathway sources
    See GeneCards unified pathways
    Show all pathways

    5/7 EMD Millipore Pathways for YWHAB (see all 7)
        Cytoskeleton remodeling Role of PKA in cytoskeleton reorganisation
    Immune response Function of MEF2 in T lymphocytes
    Cell cycle Role of 14-3-3 proteins in cell cycle regulation
    G-protein signaling G-Protein alpha-12 signaling pathway
    Development Role of HDAC and calcium/calmodulin-dependent kinase (CaMK) in control of skeletal myogenesis

    1 R&D Systems Pathway for YWHAB
        Apoptosis Signaling Pathways

    5/18 Downloadable PowerPoint Slides of QIAGEN Pathway Central Maps for YWHAB (see all 18)
        14-3-3 Induced Apoptosis
    DHA Signaling
    PKA Signaling
    ERK5 Signaling
    BDNF Pathway

    4 Cell Signaling Technology (CST) Pathways for YWHAB
        MAP Kinase Signaling
    Apoptosis and Autophagy
    Cell Cycle / Checkpoint Control
    Tyrosine Kinases / Adaptors

    2 Tocris Bioscience Pathways for YWHAB
        Insulin Pathway
    Apoptosis Pathway

    5/7 GeneGo (Thomson Reuters) Pathways for YWHAB (see all 7)
        Apoptosis and survival BAD phosphorylation
    Development Role of HDAC and calcium/calmodulin-dependent kinase (CaMK) in control of skeletal myogenesis
    Development IGF-1 receptor signaling
    Cytoskeleton remodeling Role of PKA in cytoskeleton reorganisation
    Immune response Function of MEF2 in T lymphocytes

    5/20 BioSystems Pathways for YWHAB (see all 20) 
        Calcium Regulation in the Cardiac Cell
    EGFR1 Signaling Pathway
    Myometrial Relaxation and Contraction Pathways
    SIDS Susceptibility Pathways
    Alpha6-Beta4 Integrin Signaling Pathway

    5/68        Reactome Pathways for YWHAB (see all 68)
        SHC-related events
    SHC-mediated signalling
    Intrinsic Pathway for Apoptosis
    IRS-mediated signalling
    Signaling by PDGF


    3         Kegg Pathways  (Kegg details for YWHAB):
        Cell cycle
    Oocyte meiosis
    Neurotrophin signaling pathway


    YWHAB for pathways           About GeneDecksing

    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for YWHAB

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    5/905 Interacting proteins for YWHAB (P319461, 2, 3 ENSP000003001614) via UniProtKB, MINT, STRING, and/or I2D (see all 905)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    TSC2P498152, 3, ENSP000002194764MINT-8009815 MINT-8006263 MINT-15978 MINT-50944 MINT-8006321 MINT-15979 MINT-17162 MINT-15977 I2D: score=6 STRING: ENSP00000219476
    CDC25AP303041, 2, 3, ENSP000003037064EBI-359815,EBI-747671 MINT-8004859 I2D: score=4 STRING: ENSP00000303706
    CDC25BP303052, 3, ENSP000002459604MINT-19327 MINT-8006726 MINT-51064 MINT-51065 MINT-8007484 MINT-25122 I2D: score=5 STRING: ENSP00000245960
    TPD52L1Q168902, 3, ENSP000003573874MINT-15934 MINT-15935 MINT-15933 I2D: score=2 STRING: ENSP00000357387
    YWHAQP273482, 3, ENSP000002380814MINT-7300139 MINT-7264099 MINT-7900157 I2D: score=2 STRING: ENSP00000238081
    About this table

    Gene Ontology (GO): 5/21 biological process terms (GO ID links to tree view) (see all 21):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000165MAPK cascade TAS--
    GO:0000186activation of MAPKK activity TAS--
    GO:0006605protein targeting IEA--
    GO:0006915apoptotic process TAS--
    GO:0007173epidermal growth factor receptor signaling pathway TAS--

    YWHAB for ontologies           About GeneDecksing



    Drugs & Compounds
    for YWHAB gene

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section

    YWHAB for compounds           About GeneDecksing

    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Compounds for YWHAB available from Tocris Bioscience    About this table
    CompoundAction CAS #
    DifopeinHigh affinity inhibitor of 14.3.3 proteins; induces apoptosis[396834-58-5]
    R18Inhibitor of 14.3.3 proteins; induces apoptosis[211364-78-2]

    2 HMDB Compounds for YWHAB    About this table
    CompoundSynonyms CAS #PubMed Ids
    SepiapterinL-sepiapterin (see all 8)17094-01-8--
    ZolpidemAmbien (see all 7)82626-48-0--
    1 Novoseek chemical compound relationship for YWHAB gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    serine 28.2 1 16469478 (1)

    Search CenterWatch for drugs/clinical trials and news about YWHAB / 1433B 

    Transcripts
    for YWHAB gene

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, Sirion Biotech, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section
    REFSEQ mRNAs for YWHAB gene (2 alternative transcripts): 
    NM_003404.3  NM_139323.2  

    Unigene Cluster for YWHAB:

    Tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, beta polypeptide
    Hs.643544  [show with all ESTs]
    Unigene Representative Sequence: AB209759
    7 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000353703(uc002xmu.3) ENST00000479421 ENST00000372839(uc002xmt.3)
    ENST00000428262 ENST00000445830 ENST00000477896 ENST00000479758

    miRNA
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    8/42 QIAGEN miScript miRNA Assays for microRNAs that regulate YWHAB (see all 42):
    hsa-miR-124* hsa-miR-4291 hsa-miR-429 hsa-miR-128 hsa-miR-759 hsa-miR-183* hsa-miR-1276 hsa-miR-200b
    SwitchGear 3'UTR luciferase reporter plasmid: YWHAB 3' UTR sequence
    Inhib. RNA
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    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for YWHAB (see all 7)
    OriGene shRNA RFP: YWHAB
    OriGene siRNA: YWHAB
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat YWHAB
    Sirion Biotech Custom design and validation of potent shRNA sequences against YWHAB 
    Clone
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    GenScript: all cDNA clones in your preferred vector (see all 2): YWHAB (NM_139323)
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    Additional cDNA sequence: 

    AB209759.1 AB451260.1 AB451386.1 AF064847.1 AF107406.1 AK292717.1 AL834170.1 BC001359.2 
    BC010352.1 X57346.1 

    24/43 DOTS entries (see all 43):

    DT.75122682  DT.92325870  DT.100883297  DT.100883300  DT.100059833  DT.100883284  DT.87077844  DT.100883281 
    DT.92007444  DT.120826031  DT.95256702  DT.95118446  DT.100883292  DT.100059820  DT.100883274  DT.95151410 
    DT.95151426  DT.120826094  DT.91772166  DT.100883277  DT.100883289  DT.95151421  DT.100883266  DT.120826008 

    24/1367 AceView cDNA sequences (see all 1367):

    AA113239 CA306681 W44709 AI559943 AI214594 AV713167 BQ947952 AA127557 
    NM_003404 W49730 W49656 AV757152 AA843760 CB134796 BM766686 AA305887 
    CB162977 BM765397 AA313856 BM763683 AI815029 T31374 AA070066 BM479910 

    GeneLoc Exon Structure

    5/10 Alternative Splicing Database (ASD) splice patterns (SP) for YWHAB (see all 10)    About this scheme

    ExUns: 1a · 1b ^ 2 ^ 3a · 3b ^ 4a · 4b · 4c · 4d ^ 5a · 5b · 5c ^ 6a · 6b ^ 7a · 7b ^ 8 ^ 9a · 9b · 9c
    SP1:              -     -                             -     -     -     -                                                   
    SP2:              -     -     -                       -     -     -     -                                                   
    SP3:                                                                                                                        
    SP4:                                                  -                                                                     
    SP5:                    -                                                                                                   


    ECgene alternative splicing isoforms for YWHAB

    Expression
    for YWHAB gene

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    YWHAB expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS
    CGAP TAG: CAGTTACTTA
    YWHAB Expression
    About this image
    See YWHAB Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for YWHAB

    SOURCE GeneReport for Unigene cluster: Hs.643544
        SABiosciences Custom PCR Arrays for YWHAB

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    In Situ
    Assay Products:     
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    Orthologs
    for YWHAB gene

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section
    This gene was present in the common ancestor of eukaryotes.

    Orthologs for YWHAB gene from 8/30 species (see all 30)    About this table
    Organism Taxonomic
    classification    		 Gene Description Human
    Similarity    		 Orthology
    Type    		 Details
    chicken
    (Gallus gallus)    		 Aves YWHAB1 tyrosine 3-monooxygenase/tryptophan 5-monooxygenase more 84.7(n)
    97.95(a)    		   419190  NM_001006289.1  NP_001006289.1 
    lizard
    (Anolis carolinensis)    		 Reptilia YWHAB6
    		 --
    		 97(a)
    		 1 ↔ 1
    		 4(143599907-143603773)
    African clawed frog
    (Xenopus laevis)    		 Amphibia M86928.12   -- 79.86(n)    M86928.1 
    zebrafish
    (Danio rerio)    		 Actinopterygii CA473362.12   -- 81.66(n)   323055  CA473362.1 
    fruit fly
    (Drosophila melanogaster)    		 Insecta 14-3-3&zgr;3 RAS protein signal transduction
    diacylglycerol-activated/phospholipid
    more    		 79(a)     --
    worm
    (Caenorhabditis elegans)    		 Secernentea ftt-26
    par-56
    (see all 3)    		 14-3-3-like protein 1
    (see all 3)    		 78(a)
    75(a)
    (see all 3)    		 possible ortholog
    possible ortholog
    (see all 3)    		 X(11603640-11605354)
    IV(11820482-11821901)
    thale cress
    (Arabidopsis thaliana)    		 eudicotyledons GRF36
    GRF116
    (see all 14)    		 general regulatory factor 11
    (see all 14)    		 59(a)
    58(a)
    (see all 14)    		 many ↔ many
    many ↔ many
    (see all 14)    		 5(15409697-15411516)
    1(12743821-12745648)
    rice
    (Oryza sativa)    		 Liliopsida GF14c6
    GF14f6
    (see all 8)    		 14-3-3 protein, putative, expressed
    (see all 8)    		 59(a)
    58(a)
    (see all 8)    		 many ↔ many
    many ↔ many
    (see all 8)    		 8(20809790-20812919)
    3(28656820-28661023)


    ENSEMBL Gene Tree for YWHAB (if available)
    TreeFam Gene Tree for YWHAB (if available) 

    Paralogs
    for YWHAB gene

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for YWHAB gene
    YWHAE2  YWHAH2  YWHAQ2  YWHAG2  SFN2  YWHAZ2  
    9 SIMAP similar genes for YWHAB using alignment to 4 protein entries:     1433B_HUMAN (see all proteins):
    YWHAZ    YWHAQ    14-3-3 protein    YWHAH    SFN    YWHAG
    YWHAE/FAM22B fusion    YWHAE/FAM22A fusion    YWHAE

    YWHAB for paralogs           About GeneDecksing


    2 Pseudogenes.org Pseudogenes for YWHAB
    PGOHUM00000242182 PGOHUM00000236462


    Genomic Variants
    for YWHAB gene

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/474 NCBI SNPs in YWHAB are shown (see all 474)     About this table
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance    		Chr 20 posSequence#AA
    Chg    		TypeMore#Allele
    freq    		PopTotal
    sample    		More
    ----------
    rs1510645291,2
    		C--43512385(+) ATGAC-/AGATAAC 2 -- us2k10--------
    rs1913506431,2
    		--43512426(+) AAGGGA/TCCCTG 2 -- us2k10--------
    rs1831176381,2
    		--43512526(+) TTACCA/TGACAA 2 -- us2k10--------
    rs1874088011,2
    		--43512558(+) TCACAC/TAGAAA 2 -- us2k10--------
    rs1392160041,2
    		--43512560(+) ACACAC/GAAACT 2 -- us2k10--------
    rs1925536461,2
    		--43512679(+) GGGGAA/GAAATA 2 -- us2k10--------
    rs1832246841,2
    		--43512692(+) AGCTAA/CAGGAT 2 -- us2k10--------
    rs114804481,2
    		C--43512852(+) TGAGAG/-CCAAA 2 -- us2k11Minor allele frequency- -:0.50CSA 2
    rs764568311,2
    		C--43512854(+) TGAGAG/CCAAAT 2 -- us2k11Minor allele frequency- C:0.00WA 2
    rs1924912141,2
    		--43512976(+) CCACCG/TGCCTT 2 -- us2k10--------

    HapMap Linkage Disequilibrium report for YWHAB (43514317 - 43537173 bp)
    Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
          Database of Genomic Variants (DGV) variations for YWHAB: --

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    Disorders / Diseases
    for YWHAB gene

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    YWHAB for disorders           About GeneDecksing

    OMIM gene information: 601289    OMIM disorders: --

    20/23 diseases for YWHAB (see all 23):    About MalaCards
    williams-beuren syndrome    multiple system atrophy    systemic lupus erythematosus    lupus erythematosus
    tuberous sclerosis    insulin resistance    renal cell carcinoma    lipodystrophy
    hepatitis c    bladder carcinoma    hepatocellular carcinoma    alzheimer's disease
    seizures    gastric cancer    carcinoma    glioblastoma
    hepatitis    schizophrenia    immunodeficiency    malaria

    Genetic Association Database (GAD): YWHAB
    Human Genome Epidemiology (HuGE) Navigator: YWHAB (1 document)

    Export disorders for YWHAB gene to outside databases

    Publications
    for YWHAB gene

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for YWHAB gene, integrated from 9 sources (see all 219):
    (articles sorted by number of sources associating them with YWHAB)    		    Utopia: connect your pdf to the dynamic
    world of online information

    1. Phosphorylation-dependent binding of 14-3-3 terminates signalling by the Gab2 docking protein. (PubMed id 19172738)1, 2 Brummer T.... Daly R.J. (2008)
    2. Inactivation of YAP oncoprotein by the Hippo pathway is involved in cell contact inhibition and tissue growth control. (PubMed id 17974916)1, 2 Zhao B.... Guan K.L. (2007)
    3. Homodimerization of Ror2 tyrosine kinase receptor induces 14-3- 3(beta) phosphorylation and promotes osteoblast differentiation and bone formation. (PubMed id 17717073)1, 2 Liu Y.... Billiard J. (2007)
    4. Proteomic and bioinformatic characterization of the biogenesis and function of melanosomes. (PubMed id 17081065)1, 2 Chi A....Hunt D.F. (2006)
    5. A pathway of neuregulin-induced activation of cofilin-phosphatase Slingshot and cofilin in lamellipodia. (PubMed id 15159416)1, 2 Nagata-Ohashi K.... Mizuno K. (2004)
    6. The CREB coactivator TORC2 functions as a calcium- and cAMP-sensitive coincidence detector. (PubMed id 15454081)1, 2 Screaton R.A.... Montminy M. (2004)
    7. Association of a four-amino acid residue insertion polymorphism of the HS1 gene with systemic lupus erythematosus: molecular and functional analysis. (PubMed id 15022330)1, 4 Otsuka J....Harada M. (2004)
    8. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    9. Exploring proteomes and analyzing protein processing by mass spectrometric identification of sorted N-terminal peptides. (PubMed id 12665801)1, 2 Gevaert K.... Vandekerckhove J. (2003)
    10. The DNA sequence and comparative analysis of human chromosome 20. (PubMed id 11780052)1, 2 Deloukas P....Rogers J. (2001)

    External Searches for YWHAB gene

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Free Text  
      Query String
    		PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    Genome Databases showing YWHAB gene

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 7529 HGNC: 12849 AceView: YWHAB Ensembl:ENSG00000166913 euGenes: HUgn7529
    ECgene: YWHAB Kegg: 7529 H-InvDB: YWHAB

    Other Databases showing YWHAB gene

    (According to HUGE)
    About This Section
    		   --

    Specialized Databases showing YWHAB gene

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for YWHAB Pharmacogenomics, SNPs, Pathways

    Intellectual Property
    for YWHAB gene

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    		Patent Information for YWHAB gene:
    Search GeneIP for patents involving YWHAB

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    Products
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    About This Section

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