Aliases for YWHAB Gene
Aliases for YWHAB Gene
- Tyrosine 3-Monooxygenase/Tryptophan 5-Monooxygenase Activation Protein Beta 2 3 5
- Tyrosine 3-Monooxygenase/Tryptophan 5-Monooxygenase Activation Protein, Alpha Polypeptide 2 3
- Tyrosine 3-Monooxygenase/Tryptophan 5-Monooxygenase Activation Protein, Beta Polypeptide 2 3
- 14-3-3 Alpha 2 3
- Protein 1054 3 4
- KCIP-1 3 4
- Protein Kinase C Inhibitor Protein-1 3
- Protein Kinase C Inhibitor Protein 1 4
- Brain Protein 14-3-3, Beta Isoform 3
External Ids for YWHAB Gene
- HGNC: 12849
- Entrez Gene: 7529
- Ensembl: ENSG00000166913
- OMIM: 601289
- UniProtKB: P31946
Previous HGNC Symbols for YWHAB Gene
- YWHAA
Previous GeneCards Identifiers for YWHAB Gene
- GC20P043242
- GC20P043202
- GC20P044152
- GC20P044199
- GC20P042947
- GC20P043515
- GC20P040256
Summaries for YWHAB Gene
-
This gene encodes a protein belonging to the 14-3-3 family of proteins, members of which mediate signal transduction by binding to phosphoserine-containing proteins. This highly conserved protein family is found in both plants and mammals. The encoded protein has been shown to interact with RAF1 and CDC25 phosphatases, suggesting that it may play a role in linking mitogenic signaling and the cell cycle machinery. Two transcript variants, which encode the same protein, have been identified for this gene. [provided by RefSeq, Jul 2008]
GeneCards Summary for YWHAB Gene
YWHAB (Tyrosine 3-Monooxygenase/Tryptophan 5-Monooxygenase Activation Protein Beta) is a Protein Coding gene. Diseases associated with YWHAB include Gerstmann-Straussler Disease and Eosinophilic Meningitis. Among its related pathways are mTOR Pathway and RET signaling. GO annotations related to this gene include enzyme binding and protein complex binding. An important paralog of this gene is YWHAZ.
UniProtKB/Swiss-Prot for YWHAB Gene
-
Adapter protein implicated in the regulation of a large spectrum of both general and specialized signaling pathways. Binds to a large number of partners, usually by recognition of a phosphoserine or phosphothreonine motif. Binding generally results in the modulation of the activity of the binding partner. Negative regulator of osteogenesis. Blocks the nuclear translocation of the phosphorylated form (by AKT1) of SRPK2 and antagonizes its stimulatory effect on cyclin D1 expression resulting in blockage of neuronal apoptosis elicited by SRPK2. Negative regulator of signaling cascades that mediate activation of MAP kinases via AKAP13.
-
14.3.3 proteins are a group of highly conserved proteins that are involved in many vital cellular processes such as metabolism, protein trafficking, signal transduction, apoptosis and cell cycle regulation. 14.3.3 proteins are phospho-serine/-threonine binding proteins.
No data available for CIViC summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for YWHAB Gene
Genomics for YWHAB Gene
Regulatory Elements for YWHAB Gene
Enhancers for YWHAB Gene
- Elite enhancer and/or Elite enhancer-gene association
Download GeneHancer data dump
Enhancers around YWHAB on UCSC Golden Path with GeneCards custom track
- Transcription factor binding sites by QIAGEN in the YWHAB gene promoter:
Regulatory Element Products
Genomic Location for YWHAB Gene
- Chromosome:
- 20
- Start:
- 44,885,599 bp from pter
- End:
- 44,908,532 bp from pter
- Size:
- 22,934 bases
- Orientation:
- Plus strand
Genomic View for YWHAB Gene
Genes around YWHAB on UCSC Golden Path with GeneCards custom track
- Cytogenetic band:
-
- 20q13.12 by Ensembl
- 20q13.12 by Entrez Gene
- 20q13.12 by HGNC
YWHAB Gene in genomic location: bands according to
Ensembl, locations according to GeneLoc
(and/or Entrez Gene and/or Ensembl if different)
Genomic Neighborhood
• Exon Structure
• Gene Density
RefSeq DNA sequence for YWHAB Gene
Proteins for YWHAB Gene
-
Protein details for YWHAB Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- P31946-1433B_HUMAN
- Recommended name:
- 14-3-3 protein beta/alpha
- Protein Accession:
- P31946
- A8K9K2
- E1P616
Protein attributes for YWHAB Gene
- Size:
- 246 amino acids
- Molecular mass:
- 28082 Da
- Quaternary structure:
-
- Homodimer (PubMed:17717073). Interacts with SAMSN1 and PRKCE (By similarity). Interacts with AKAP13 (PubMed:21224381). Interacts with SSH1 and TORC2/CRTC2 (PubMed:15454081, PubMed:15159416). Interacts with ABL1; the interaction results in cytoplasmic location of ABL1 and inhibition of cABL-mediated apoptosis (PubMed:15696159). Interacts with ROR2 (dimer); the interaction results in phosphorylation of YWHAB on tyrosine residues (PubMed:17717073). Interacts with GAB2 (PubMed:19172738). Interacts with YAP1 (phosphorylated form) (PubMed:17974916). Interacts with the phosphorylated (by AKT1) form of SRPK2 (PubMed:19592491). Interacts with PKA-phosphorylated AANAT (PubMed:11427721). Interacts with MYO1C (PubMed:24636949). Interacts with SIRT2 (PubMed:18249187). Interacts with the Thr-369 phosphorylated form of DAPK2 (PubMed:26047703). Interacts with PI4KB, TBC1D22A and TBC1D22B (PubMed:23572552). Interacts with the Ser-1134 and Ser-1161 phosphorylated form of SOS1 (PubMed:22827337). Interacts (via phosphorylated form) with YWHAB; this interaction occurs in a protein kinase AKT1-dependent manner (PubMed:15538381). Interacts with SLITRK1 (PubMed:19640509). Interacts with SYNPO2 (phosphorylated form); YWHAB competes with ACTN2 for interaction with SYNPO2 (By similarity).
- (Microbial infection) Interacts with herpes simplex virus 1 protein UL46.
Protein Expression for YWHAB Gene
Post-translational modifications for YWHAB Gene
- The alpha, brain-specific form differs from the beta form in being phosphorylated. Phosphorylated on Ser-60 by protein kinase C delta type catalytic subunit in a sphingosine-dependent fashion.
- Ubiquitination at Lys11, posLast=117117, and isoforms=2140
- Modification sites at PhosphoSitePlus
Other Protein References for YWHAB Gene
- ENSEMBL proteins:
- REFSEQ proteins:
Antibody Products
- R&D Systems Antibodies for YWHAB (14-3-3 beta)
- Cell Signaling Technology (CST) Antibodies for YWHAB (14-3-3 beta)
- Novus Biologicals Antibodies for YWHAB
- Invitrogen Antibodies for YWHAB
- antibodies-online Antibodies for YWHAB: See all 130
- GeneTex YWHAB antibody for YWHAB
-
Santa Cruz Biotechnology (SCBT) Antibodies for YWHAB
Protein Products
- Search Origene for MassSpec and Protein Over-expression Lysates for YWHAB
- Origene Custom Protein Services for YWHAB
- Sino Biological Recombinant Proteins for YWHAB
- Browse Sino Biological Cell Lysates
- ProSpec Recombinant Proteins for YWHAB
- antibodies-online Proteins for YWHAB: See all 7
- Search antibodies-online for peptides
- Search GeneTex for Proteins for YWHAB
-
ProSci Proteins for YWHAB
Assay Products
- antibodies-online Kits for YWHAB: See all 8
No data available for DME Specific Peptides for YWHAB Gene
Domains & Families for YWHAB Gene
Gene Families for YWHAB Gene
Protein Domains for YWHAB Gene
- InterPro:
- Blocks:
- ProtoNet:
Suggested Antigen Peptide Sequences for YWHAB Gene
- GenScript: Design optimal peptide antigens:
Graphical View of Domain Structure for InterPro Entry
P31946- Family:
-
- Belongs to the 14-3-3 family.
Function for YWHAB Gene
Molecular function for YWHAB Gene
- GENATLAS Biochemistry:
- tyrosine 3-monooxygenase/trytophan 5 monooxygenase activation protein,14-3-3 beta protein,including the phosphorylated form YWHAA (alpha),multifunctional regulator involved in cell-cyle control (checkpoint) and signal transduction,inhibitor of apoptosis through inhibiting the activation of p38 MAP kinase
- UniProtKB/Swiss-Prot Function:
- Adapter protein implicated in the regulation of a large spectrum of both general and specialized signaling pathways. Binds to a large number of partners, usually by recognition of a phosphoserine or phosphothreonine motif. Binding generally results in the modulation of the activity of the binding partner. Negative regulator of osteogenesis. Blocks the nuclear translocation of the phosphorylated form (by AKT1) of SRPK2 and antagonizes its stimulatory effect on cyclin D1 expression resulting in blockage of neuronal apoptosis elicited by SRPK2. Negative regulator of signaling cascades that mediate activation of MAP kinases via AKAP13.
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0003714 | transcription corepressor activity | IEA | -- |
| GO:0005515 | protein binding | IPI | 7644510 |
| GO:0008022 | protein C-terminus binding | IEA | -- |
| GO:0019899 | enzyme binding | IPI | 17255105 |
| GO:0019904 | protein domain specific binding | IPI,IEA | 11984006 |
Phenotypes for YWHAB Gene
- GenomeRNAi human phenotypes for YWHAB:
Animal Model Products
- Taconic Biosciences: Generate A Custom CRISPR Mouse Model For Your Study
- Cyagen custom Knockout/knockin (KOKI) mouse models for YWHAB
-
-
ViGene Biosciences lentiviral particle packaged cDNA for YWHAB gene
-
ViGene Biosciences ready-to-package AAV shRNAs for YWHAB gene
- Search ViGene Biosciences for YWHAB
CRISPR Products
-
OriGene CRISPR knockouts for YWHAB
-
Santa Cruz Biotechnology (SCBT) CRISPR for YWHAB
- GenScript: Design CRISPR guide RNA sequences for YWHAB
miRNA for YWHAB Gene
- miRTarBase miRNAs that target YWHAB
-
- hsa-mir-1301-3p (MIRT035990)
- hsa-mir-877-3p (MIRT037014)
- hsa-mir-378a-5p (MIRT044012)
- hsa-mir-221-3p (MIRT046917)
- hsa-mir-218-5p (MIRT439267)
- hsa-mir-627-3p (MIRT505094)
- hsa-mir-6758-3p (MIRT505095)
- hsa-mir-5094 (MIRT505096)
- hsa-mir-513c-3p (MIRT505097)
- hsa-mir-513a-3p (MIRT505098)
- hsa-mir-3606-3p (MIRT505099)
- hsa-mir-551b-5p (MIRT505100)
- hsa-mir-148b-3p (MIRT505101)
- hsa-mir-148a-3p (MIRT505102)
- hsa-mir-152-3p (MIRT505103)
- hsa-mir-744-3p (MIRT529358)
- hsa-mir-620 (MIRT529359)
- hsa-mir-1270 (MIRT529360)
- hsa-mir-4423-5p (MIRT529361)
- hsa-mir-6501-5p (MIRT529362)
- hsa-mir-143-5p (MIRT529363)
- hsa-mir-4430 (MIRT529364)
- hsa-mir-3652 (MIRT529365)
- hsa-mir-122-5p (MIRT529366)
- hsa-mir-504-3p (MIRT529367)
- hsa-mir-4683 (MIRT529368)
- hsa-mir-3135b (MIRT529369)
- hsa-mir-6088 (MIRT529370)
- hsa-mir-4770 (MIRT529371)
- hsa-mir-143-3p (MIRT529372)
- hsa-mir-4781-3p (MIRT529373)
- hsa-mir-4457 (MIRT641784)
- hsa-mir-7850-5p (MIRT706790)
- hsa-mir-4531 (MIRT706791)
miRNA Products
- Search ViGene Biosciences for YWHAB
Inhibitory RNA Products
- Origene RNAi, siRNA, and shRNA products in human, mouse, rat for YWHAB
- Browse OriGene Inhibitory RNA Products For YWHAB
-
ViGene Biosciences ready-to-package AAV shRNAs for YWHAB gene
Clone Products
- Sino Biological Human cDNA Clone for YWHAB
- Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat
- Addgene plasmids for YWHAB
- VectorBuilder custom plasmid, inducible vectors for YWHAB
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for YWHAB
-
VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
Cell Line Products
-
Horizon Cell Lines for YWHAB
-
ViGene Biosciences adenoviral particle packaged cDNA for YWHAB gene
-
ViGene Biosciences lentiviral particle packaged cDNA for YWHAB gene
-
ViGene Biosciences ready-to-package AAV shRNAs for YWHAB gene
No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for YWHAB Gene
Localization for YWHAB Gene
Subcellular locations from UniProtKB/Swiss-Prot for YWHAB Gene
- Cytoplasm. Melanosome. Note=Identified by mass spectrometry in melanosome fractions from stage I to stage IV.
| Compartment | Confidence |
|---|---|
| extracellular | 5 |
| cytosol | 5 |
| nucleus | 4 |
| mitochondrion | 2 |
| plasma membrane | 1 |
| cytoskeleton | 1 |
| endoplasmic reticulum | 1 |
| golgi apparatus | 1 |
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0005634 | nucleus | IEA | -- |
| GO:0005737 | cytoplasm | IDA,IEA | 10869435 |
| GO:0005739 | mitochondrion | IEA | -- |
| GO:0005829 | cytosol | TAS | -- |
| GO:0005925 | focal adhesion | IDA | 21423176 |
Pathways & Interactions for YWHAB Gene
| SuperPathway | Contained pathways | ||
|---|---|---|---|
| 1 | RET signaling |
.92
|
.92
|
| 2 | CDK-mediated phosphorylation and removal of Cdc6 |
.31
|
|
| 3 | Signaling by moderate kinase activity BRAF mutants | ||
| 4 | Activation of cAMP-Dependent PKA |
.77
|
.56
|
| 5 | mTOR signalling |
.70
|
.51
|
Pathways by source for YWHAB Gene
6 Sino Biological pathways for YWHAB Gene
2 GeneTex pathways for YWHAB Gene
4 Cell Signaling Technology pathways for YWHAB Gene
17 BioSystems pathways for YWHAB Gene
87 Reactome pathways for YWHAB Gene
7 KEGG pathways for YWHAB Gene
7 GeneGo (Thomson Reuters) pathways for YWHAB Gene
- Apoptosis and survival BAD phosphorylation
- Cell cycle Role of 14-3-3 proteins in cell cycle regulation
- Cytoskeleton remodeling Role of PKA in cytoskeleton reorganisation
- Development IGF-1 receptor signaling
- Development Role of HDAC and calcium/calmodulin-dependent kinase (CaMK) in control of skeletal myogenesis
2 R&D Systems pathways for YWHAB Gene
2 Tocris pathways for YWHAB Gene
Interacting Proteins for YWHAB Gene
Selected Interacting proteins:
P31946-1433B_HUMAN
ENSP00000300161
for YWHAB Gene via
MINT
STRING
UniProtKB
IID
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0000165 | MAPK cascade | TAS | -- |
| GO:0006605 | protein targeting | IEA | -- |
| GO:0016032 | viral process | IEA | -- |
| GO:0035308 | negative regulation of protein dephosphorylation | IDA | 17255105 |
| GO:0035329 | hippo signaling | TAS | -- |
Drugs & Compounds for YWHAB Gene
| Name | Synonyms | Role | CAS Number | PubChem IDs | PubMed IDs | |
|---|---|---|---|---|---|---|
| Sepiapterin |
|
17094-01-8 |
|
|||
| Difopein |
|
396834-58-5 |
|
|
(2) Tocris Compounds for YWHAB Gene
(1) ApexBio Compounds for YWHAB Gene
| Compound | Action | Cas Number |
|---|---|---|
| R18 | 14.3.3 proteins Antagonist | 211364-78-2 |
Transcripts for YWHAB Gene
mRNA/cDNA for YWHAB Gene
- (4) REFSEQ mRNAs :
- (10) Additional mRNA sequences :
- (1367) Selected AceView cDNA sequences:
- (8) Ensembl transcripts including schematic representations, and UCSC links where relevant :
Unigene Clusters for YWHAB Gene
CRISPR Products
-
OriGene CRISPR knockouts for YWHAB
-
Santa Cruz Biotechnology (SCBT) CRISPR for YWHAB
- GenScript: Design CRISPR guide RNA sequences for YWHAB
miRNA Products
- Search ViGene Biosciences for YWHAB
Inhibitory RNA Products
- Origene RNAi, siRNA, and shRNA products in human, mouse, rat for YWHAB
- Browse OriGene Inhibitory RNA Products For YWHAB
-
ViGene Biosciences ready-to-package AAV shRNAs for YWHAB gene
Clone Products
- Sino Biological Human cDNA Clone for YWHAB
- Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat
- Addgene plasmids for YWHAB
- VectorBuilder custom plasmid, inducible vectors for YWHAB
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for YWHAB
-
VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
| ExUns: | 1a | · | 1b | ^ | 2 | ^ | 3a | · | 3b | ^ | 4a | · | 4b | · | 4c | · | 4d | ^ | 5a | · | 5b | · | 5c | ^ | 6a | · | 6b | ^ | 7a | · | 7b | ^ | 8 | ^ | 9a | · | 9b | · | 9c |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| SP1: | - | - | - | - | - | - | |||||||||||||||||||||||||||||||||
| SP2: | - | - | - | - | - | - | - | ||||||||||||||||||||||||||||||||
| SP3: | |||||||||||||||||||||||||||||||||||||||
| SP4: | - | ||||||||||||||||||||||||||||||||||||||
| SP5: | - | ||||||||||||||||||||||||||||||||||||||
| SP6: | |||||||||||||||||||||||||||||||||||||||
| SP7: | - | - | - | - | - | - | |||||||||||||||||||||||||||||||||
| SP8: | - | - | - | - | - | - | |||||||||||||||||||||||||||||||||
| SP9: | - | ||||||||||||||||||||||||||||||||||||||
| SP10: | - | - | - |
Expression for YWHAB Gene
Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for YWHAB Gene
- Elite partner
NURSA nuclear receptor signaling pathways regulating expression of YWHAB Gene:
YWHABSOURCE GeneReport for Unigene cluster for YWHAB Gene:
Hs.643544Evidence on tissue expression from TISSUES for YWHAB Gene
- Skin(4.9)
- Nervous system(4.9)
- Liver(4.7)
- Blood(4.6)
- Intestine(4.2)
- Lung(4.1)
- Pancreas(3.9)
- Kidney(3.5)
- Eye(3.1)
- Heart(2.5)
- Spleen(2.2)
- Lymph node(2.1)
- Muscle(2.1)
- Stomach(2)
Primer Products
-
OriGene qPCR primer pairs for YWHAB
-
OriGene qPCR primer pairs and template standards for YWHAB
No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for YWHAB Gene
Orthologs for YWHAB Gene
This gene was present in the common ancestor of animals.
| Organism | Taxonomy | Gene | Similarity | Type | Details |
|---|---|---|---|---|---|
| chimpanzee (Pan troglodytes) |
Mammalia | YWHAB 34 35 |
|
||
| dog (Canis familiaris) |
Mammalia | YWHAB 34 35 |
|
||
| cow (Bos Taurus) |
Mammalia | YWHAB 34 35 |
|
||
| oppossum (Monodelphis domestica) |
Mammalia | YWHAB 35 |
|
OneToOne | |
| rat (Rattus norvegicus) |
Mammalia | Ywhab 34 |
|
||
| mouse (Mus musculus) |
Mammalia | Ywhab 34 16 35 |
|
||
| platypus (Ornithorhynchus anatinus) |
Mammalia | YWHAB 35 |
|
OneToOne | |
| chicken (Gallus gallus) |
Aves | YWHAB 34 35 |
|
||
| lizard (Anolis carolinensis) |
Reptilia | YWHAB 35 |
|
OneToOne | |
| tropical clawed frog (Silurana tropicalis) |
Amphibia | ywhab 34 |
|
||
| zebrafish (Danio rerio) |
Actinopterygii | ywhabb 35 |
|
OneToMany | |
| ywhaba 34 35 |
|
||||
| -- 34 |
|
||||
| fruit fly (Drosophila melanogaster) |
Insecta | 14-3-3zgr 36 |
|
|
|
| 14-3-3zeta 35 |
|
OneToMany | |||
| worm (Caenorhabditis elegans) |
Secernentea | ftt-2 35 |
|
ManyToMany | |
| par-5 35 |
|
ManyToMany | |||
| sea squirt (Ciona intestinalis) |
Ascidiacea | Cin.4900 34 |
|
- Species where no ortholog for YWHAB was found in the sources mined by GeneCards:
-
- A. gosspyii yeast (Ashbya gossypii)
- Actinobacteria (Mycobacterium tuberculosis)
- African clawed frog (Xenopus laevis)
- African malaria mosquito (Anopheles gambiae)
- Alicante grape (Vitis vinifera)
- alpha proteobacteria (Wolbachia pipientis)
- amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- baker's yeast (Saccharomyces cerevisiae)
- barley (Hordeum vulgare)
- beta proteobacteria (Neisseria meningitidis)
- bread mold (Neurospora crassa)
- Chromalveolata (Phytophthora infestans)
- common water flea (Daphnia pulex)
- corn (Zea mays)
- E. coli (Escherichia coli)
- filamentous fungi (Aspergillus nidulans)
- Firmicute bacteria (Streptococcus pneumoniae)
- fission yeast (Schizosaccharomyces pombe)
- green algae (Chlamydomonas reinhardtii)
- honey bee (Apis mellifera)
- K. lactis yeast (Kluyveromyces lactis)
- loblloly pine (Pinus taeda)
- malaria parasite (Plasmodium falciparum)
- medicago trunc (Medicago Truncatula)
- moss (Physcomitrella patens)
- orangutan (Pongo pygmaeus)
- pig (Sus scrofa)
- rainbow trout (Oncorhynchus mykiss)
- rice (Oryza sativa)
- rice blast fungus (Magnaporthe grisea)
- schistosome parasite (Schistosoma mansoni)
- sea anemone (Nematostella vectensis)
- sea urchin (Strongylocentrotus purpuratus)
- sorghum (Sorghum bicolor)
- soybean (Glycine max)
- stem rust fungus (Puccinia graminis)
- sugarcane (Saccharum officinarum)
- thale cress (Arabidopsis thaliana)
- tomato (Lycopersicon esculentum)
- toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
- wheat (Triticum aestivum)
Paralogs for YWHAB Gene
(9) SIMAP similar genes for YWHAB Gene using alignment to 4 proteins:
Pseudogenes.org Pseudogenes for YWHAB Gene
Variants for YWHAB Gene
| SNP ID | Clin | Chr 20 pos | Sequence Context | AA Info | Type |
|---|---|---|---|---|---|
| rs1000078233 | -- | 44,887,523(+) | ATCTT(C/T)TGTAC | intron-variant | |
| rs1000120262 | -- | 44,885,261(+) | AGTAA(A/G)AGGAC | upstream-variant-2KB | |
| rs1000317881 | -- | 44,890,836(+) | ATCCG(A/G)TGTGG | intron-variant | |
| rs1000483521 | -- | 44,902,788(+) | TTTGC(A/G)TTGAG | intron-variant | |
| rs1000575536 | -- | 44,885,018(+) | TCAAG(A/C)AATCC | upstream-variant-2KB |
| Variant ID | Type | Subtype | PubMed ID |
|---|---|---|---|
| nsv1056102 | CNV | loss | 25217958 |
| nsv1058850 | CNV | gain | 25217958 |
| nsv1062628 | CNV | gain | 25217958 |
| nsv518547 | CNV | gain | 19592680 |
| nsv586077 | CNV | gain | 21841781 |
| nsv954044 | CNV | duplication | 24416366 |
Residual Variation Intolerance Score:
35.3% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score:
0.64;
13.61% of all genes are more intolerant (likely to be disease-causing)
Relevant External Links for YWHAB Gene
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for YWHAB Gene
Disorders for YWHAB Gene
| Disorder | Aliases | PubMed IDs |
|---|---|---|
| gerstmann-straussler disease |
|
|
| eosinophilic meningitis |
|
|
| chronic meningitis |
|
|
| vulva squamous cell carcinoma |
|
|
Search YWHAB in MalaCards
View complete list of genes associated with diseases
Relevant External Links for YWHAB
No data available for UniProtKB/Swiss-Prot and Genatlas for YWHAB Gene
Publications for YWHAB Gene
- Crystal structure of human myosin 1c - the motor in GLUT4 exocytosis: implications for Ca(2+)-regulation and 14-3-3 binding. (PMID: 24636949) Stefan Munnich M.H. … Manstein D.J. (J. Mol. Biol. 2014) 3 4 64
- ACBD3 interaction with TBC1 domain 22 protein is differentially affected by enteroviral and kobuviral 3A protein binding. (PMID: 23572552) Greninger A.L. … DeRisi J.L. (MBio 2013) 3 4 64
- A proteomic perspective of inbuilt viral protein regulation: pUL46 tegument protein is targeted for degradation by ICP0 during herpes simplex virus type 1 infection. (PMID: 23938468) Lin A.E. … Cristea I.M. (Mol. Cell Proteomics 2013) 3 4 64
- A-kinase anchoring protein (AKAP)-Lbc anchors a PKN-based signaling complex involved in I+1-adrenergic receptor-induced p38 activation. (PMID: 21224381) Cariolato L. … Diviani D. (J. Biol. Chem. 2011) 3 4 64
- Interaction of Akt-phosphorylated SRPK2 with 14-3-3 mediates cell cycle and cell death in neurons. (PMID: 19592491) Jang S.W. … Ye K. (J. Biol. Chem. 2009) 3 4 64
Products for YWHAB Gene
- R&D Systems Antibodies for YWHAB (14-3-3 beta)
- Browse R&D Systems for Human Recombinant Proteins
- Browse R&D Systems for biochemical assays
- Browse Primary Antibodies
- Browse Proteins and Enzymes
- Browse ELISAs
- Browse Activity Assays
- Browse cDNA Clones
- Browse Cell Culture Products
- Browse Cell Selection and Detection Kits
- Browse DNA Damage and Repair Kits
- Browse ELISpot/FluoroSpot Kits and Development Modules
- Browse Flow Cytometry Kits
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- Browse Peptides
- Browse Proteome Profiler Antibody Arrays
- Browse Small Molecules
- Custom Antibody ServicesOriGene Antibodies for YWHAB
- Browse OriGene ELISA Kits
- Custom Assay Services
- Search Origene for MassSpec and Protein Over-expression Lysates for YWHAB
- Origene Custom Protein Services for YWHAB
- Origene shRNA, siRNA, and RNAi products in human, mouse, rat for YWHAB
- Browse OriGene Inhibitory RNA Products For YWHAB
- OriGene qPCR primer pairs and template standards for YWHAB
- OriGene qPCR primer pairs for YWHAB
- OriGene CRISPR knockouts for YWHAB
- OriGene ORF clones in human for YWHAB
- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
- Browse OriGene miRNA Products For YWHAB
- GenScript: Next-day shipping cDNA ORF clone for YWHAB in any vector
- GenScript Custom Purified and Recombinant Proteins Services for YWHAB
- GenScript Custom Assay Services for YWHAB
- GenScript Custom overexpressing Cell Line Services for YWHAB
- GenScript: Design CRISPR guide RNA sequences for YWHAB
- Design optimal peptide antigens
- CloneReady with Over 120,000 Genes
- Gene Synthesis: Any Gene in Any Vector
- Vector-based siRNA and miRNA, Ready for Transfection
- Gene Mutant Library, Variants up to 10^11
- Plasmid Preparation
- GenScript Custom Peptide Services for YWHAB
- Cell Signaling Technology (CST) Antibodies for YWHAB (14-3-3 beta)
- Search for Antibodies & Assays
- Sino Biological Human cDNA Clone for YWHAB
- Sino Biological Recombinant Proteins for YWHAB
- Browse Sino Biological Cell Lysates
- Sino Biological Antibodies
- Sino Biological ELISA Kits and Pair Sets
- Sino Biological Cell Lysates
- Sino Biological qPCR Primers
- Sino Biological CRO Services for Proteins, Antibodies and Genes
- Sino Biological Transfection Reagents
- Novus Biologicals Antibodies for YWHAB
- Novus Biologicals proteins and lysates for YWHAB
- Novus Biologicals
- Novus Biologicals Tissue Microarrays
- ProSpec Recombinant Proteins for YWHAB
- Invitrogen Antibodies for YWHAB
- Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat
- ApexBio compounds for YWHAB
- Addgene plasmids for YWHAB
- antibodies-online Antibodies for YWHAB: See all 130
- antibodies-online Kits for YWHAB: See all 8
- antibodies-online Proteins for YWHAB: See all 7
- Search antibodies-online for peptides
- GeneTex YWHAB antibody for YWHAB
- Search GeneTex for Proteins for YWHAB
- ViGene Biosciences adenoviral particle packaged cDNA for YWHAB gene
- ViGene Biosciences lentiviral particle packaged cDNA for YWHAB gene
- ViGene Biosciences ready-to-package AAV shRNAs for YWHAB gene
- Search ViGene Biosciences for YWHAB
- Santa Cruz Biotechnology (SCBT) Antibodies for YWHAB
- Search Santa Cruz Biotechnology (SCBT) for YWHAB siRNA/shRNA
- Santa Cruz Biotechnology (SCBT) CRISPR for YWHAB
- Horizon Cell Lines for YWHAB
- Cyagen custom Knockout/knockin (KOKI) mouse models for YWHAB
- VectorBuilder custom plasmid, inducible vectors for YWHAB
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for YWHAB
- VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
Sources for YWHAB Gene
- (1) GeneCards
- (2) HGNC
- (3) EntrezGene
- (4) Swiss-Prot
- (5) Ensembl
- (6) OMIM
- (7) GeneLoc
- (8) Gene Wiki
- (9) UCSC
- (10) PhosphoSitePlus
- (11) GO
- (12) TrEMBL
- (13) InterPro
- (14) ProtoNet
- (15) Blocks
- (16) MGI
- (17) IUBMB
- (18) KEGG
- (19) MINT
- (20) STRING
- (21) IntAct
- (22) Novoseek
- (23) PharmGKB
- (24) DrugBank
- (25) HMDB
- (26) UniGene
- (27) AceView
- (28) RNAdb
- (29) ASD
- (30) ECgene
- (31) GeneAnnot
- (32) CGAP SAGE
- (33) SOURCE
- (34) HomoloGene
- (35) PanEnsembl
- (36) euGenes
- (37) SGD
- (38) FlyBase
- (39) WormBase
- (40) Pseudogene
- (41) DGV
- (42) dbSNP
- (43) GenAtlas
- (44) GeneTests
- (45) HGMD
- (46) GAD
- (47) LSDB
- (48) BGMUT
- (49) HuGE
- (50) eBioscience
- (51) Atlas
- (52) Cell Signaling Technology
- (53) GenBank
- (54) H-invDB
- (55) HORDE
- (56) HUGE
- (57) IMGT
- (58) Leiden
- (59) MILLIPORE
- (60) miRBase
- (61) DME
- (62) NCBI
- (63) OriGene
- (64) PubMed
- (65) R&D Systems
- (66) TGDB
- (67) Tocris
- (68) Abcam
- (69) Novus
- (70) ProSpec
- (71) Sino Biological
- (72) GenScript
- (73) Qiagen
- (74) Cloud-Clone Corp.
- (75) Enzo Life Sciences
- (76) OCA
- (77) Proteopedia
- (78) MOPED
- (79) SPIRE
- (80) neXtProt
- (81) Reactome
- (82) GeneGo (Thomson Reuters)
- (83) fRNAdb
- (84) DISEASES
- (85) SIMAP
- (86) GenomeRNAi
- (87) LifeMap
- (88) miRTarBase
- (89) MalaCards
- (90) Invitrogen
- (91) BitterDB
- (92) Vector BioLabs
- (93) ESI-BIO
- (94) RefSeq
- (95) BioSystems
- (96) MaxQB
- (97) IUPHAR
- (98) BioGPS
- (99) Illumina
- (100) COMPARTMENTS
- (101) HOMER
- (102) PaxDb
- (103) ApexBio
- (104) Addgene
- (105) antibodies-online
- (106) CYP
- (107) NONCODE
- (108) SwitchGear Genomics
- (109) TreeFam
- (110) PathCards
- (111) GeneReviews
- (112) GeneTex
- (113) Taconic Biosciences
- (114) GTEx
- (115) ProteomicsDB
- (116) SCBT
- (117) DGIdb
- (118) ClinicalTrials
- (119) FDA Approved Drugs
- (120) RVIS
- (121) SIGNOR
- (122) diseasecard
- (123) NIH Rare Diseases
- (124) Orphanet
- (125) UMLS
- (126) GTR
- (127) Disease Ontology
- (128) Genetics Home Reference
- (129) MeSH
- (130) MedlinePlus
- (131) CDC
- (132) NINDS
- (133) NCBI Bookshelf
- (134) ClinVar
- (135) Gene Damage Index
- (136) ViGene Biosciences
- (137) HPO
- (138) UDN
- (139) VISTA
- (140) FANTOM5
- (141) ENCODE
- (142) ProSci
- (143) Horizon
- (144) NURSA
- (145) IID
- (146) Cyagen
- (147) VectorBuilder
- (148) SNPedia
- (149) BRCA Exchange
- (150) St John's Lab
- (151) CIViC
- (152) ProteoGenix
- (153) dbSUPER
- (154) TISSUES
- (155) Gene ORGANizer