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Category Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21

GIFtS
-

YWHAB Gene

protein-coding GIFtS: 67
GCID: GC20P043515

tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation...

(Previous names: tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation...)
(Previous symbol: YWHAA)

Explore 23 diseases affiliated with
YWHAB via

MalaCards

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Human Malady Compendium

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc, ⁷Ensembl, ⁸DME, ⁹miRBase, and/or ¹⁰fRNAdb)
About This Section

Aliases
Tyrosine 3-Monooxygenase/Tryptophan 5-Monooxygenase Activation Protein, Beta Polypeptide¹ ²		14-3-3 Alpha²
YWHAA¹ ²		14-3-3 Protein Beta/Alpha²
Tyrosine 3-Monooxygenase/Tryptophan 5-Monooxygenase Activation Protein, Alpha Polypeptide¹ ²		GW128²
Protein 1054² ³		HS1²
Protein Kinase C Inhibitor Protein 1² ³		Brain Protein 14-3-3, Beta Isoform²
KCIP-1² ³		Protein Kinase C Inhibitor Protein-1²

External Ids:	HGNC: 12849¹	Entrez Gene: 7529²	Ensembl: ENSG00000166913⁷	OMIM: 601289⁵	UniProtKB: P31946³

Export aliases for YWHAB gene to outside databases

Previous GC identifers: GC20P043242 GC20P043202 GC20P044152 GC20P044199 GC20P042947 GC20P040256

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for YWHAB:

This gene encodes a protein belonging to the 14-3-3 family of proteins, members of which mediate signal transduction by

binding to phosphoserine-containing proteins. This highly conserved protein family is found in both plants and

mammals. The encoded protein has been shown to interact with RAF1 and CDC25 phosphatases, suggesting that it may play

a role in linking mitogenic signaling and the cell cycle machinery. Two transcript variants, which encode the same

protein, have been identified for this gene. (provided by RefSeq, Jul 2008)

UniProtKB/Swiss-Prot: 1433B_HUMAN, P31946

Function: Adapter protein implicated in the regulation of a large spectrum of both general and specialized signaling

pathways. Binds to a large number of partners, usually by recognition of a phosphoserine or phosphothreonine motif.

Binding generally results in the modulation of the activity of the binding partner. Negative regulator of

osteogenesis. Blocks the nuclear translocation of the phosphorylated form (by AKT1) of SRPK2 and antagonizes its

stimulatory effect on cyclin D1 expression resulting in blockage of neuronal apoptosis elicited by SRPK2

summary for YWHAB:

14.3.3 proteins are a group of highly conserved proteins that are involved in many vital cellular processes

such as metabolism, protein trafficking, signal transduction, apoptosis and cell cycle regulation. 14.3.3

proteins are phospho-serine/phospho-threonine binding proteins that have a diverse array of partners

including transcription factors, biosynthetic enzymes, cytoskeletal proteins, signalling molecules,

apoptosis factors and tumour suppressors. The 14.3.3 family consists of 7 isoforms; beta, gamma, epsilon,

sigma, zeta, tau and eta. 14.3.3 proteins are ubiquitously expressed and self assemble into homo- and

heterodimers, with the exception of 14.3.3sigma, which exclusively forms homodimers and is found in cells of

epithelial origin only. Each monomer contains an independent ligand-binding site, thus the 14.3.3 dimer can

interact with two target proteins simultaneously. 14.3.3 proteins are highly rigid structures and ligand

binding can induce conformational changes that alter the stability and/or catalytic activity of the ligand.

Furthermore, 14.3.3 protein binding can physically occlude sequence-specific or structural motifs on the

target that prevent molecular interactions and/or modulate the accessibility of a target protein to

modifying enzymes such as kinases, phosphatases and proteases. In addition, 14.3.3 proteins can act as a

scaffold molecule to anchor target proteins within close proximity of one another. 14.3.3 proteins represent

an integration point for proliferative, survival, apoptotic and stress signalling pathways. Members of the

14.3.3 protein family enhance the activity of many proteins with proliferative and/or survival functions,

such as Raf kinases, and antagonise the activity of proteins that promote cell death and senescence, such as

Bad, Bim and Bax. In contrast, 14.3.3sigma acts as a tumour suppressor and its expression is upregulated

coordinately with p53 and BRAC1. This isoform sequesters cdk1-cyclin B complexes in the cytoplasm, and thus

delays cell cycle progression. 14.3.3sigma is also a crucial regulator of translation during mitosis.

Because many 14.3.3 interactions are phosphorylation dependent, 14.3.3 proteins have been integrated into

the core regulatory pathways that are crucial for normal growth and development. 14.3.3 proteins are

directly involved in cellular processes such as cytokinesis, cell-contact inhibition, anchorage-independent

growth and cell adhesion, and it is these pathways that often become dysregulated in disease states such as

cancer.

Gene Wiki entry for YWHAB

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section

RefSeq DNA sequence:

NC_000020.10 NC_018931.1 NT_011362.10

Regulatory elements:

SABiosciences Regulatory transcription factor binding sites in the YWHAB gene promoter:
MEF-2 E47 CREB MEF-2A POU2F1 FOXJ2 (long isoform) POU2F1a Hand1 FOXJ2 aMEF-2
Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: YWHAB promoter sequence

Search SABiosciences Chromatin IP Primers for YWHAB

Epigenetics:

QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat YWHAB

Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 20q13.1 Ensembl cytogenetic band: 20q13.12 HGNC cytogenetic band: 20q13.1

YWHAB Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
YWHAB gene location

GeneLoc information about chromosome 20 GeneLoc Exon Structure

GeneLoc location for GC20P043515: view genomic region (about GC identifiers)

Start:	43,514,317 bp from pter	End:	43,537,173 bp from pter
Size:	22,857 bases	Orientation:	plus strand

(According to ¹UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to ²PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section

UniProtKB/Swiss-Prot: 1433B_HUMAN, P31946 (See protein sequence)

Recommended Name: 14-3-3 protein beta/alpha

Size: 246 amino acids; 28082 Da

Subunit: Homodimer. Interacts with SAMSN1 and KRPCE (By similarity). Interacts with SSH1 and TORC2/CRTC2. Interacts

with ABL1; the interaction results in cytoplasmic location of ABL1 and inhibition of cABL-mediated apoptosis.

Interacts with ROR2 (dimer); the interaction results in phosphorylation of YWHAB on tyrosine residues. Interacts with

GAB2 and YAP1 (phosphorylated form). Interacts with the phosphorylated (by AKT1) form of SRPK2. Interacts with

PKA-phosphorylated AANAT

Subcellular location: Cytoplasm. Melanosome. Note=Identified by mass spectrometry in melanosome fractions from stage I

to stage IV

3 PDB 3D structures from and Proteopedia for YWHAB:

2BQ0 (3D)

2C23 (3D)

4DNK (3D)

Secondary accessions: A8K9K2 E1P616

Alternative initiation: 2 isoforms: P31946-1 P31946-2 (Contains a N-acetylmethionine at position 1 (By similarity))

Explore the universe of human proteins at neXtProt for YWHAB: NX_P31946

Post-translational modifications:

The alpha, brain-specific form differs from the beta form in being phosphorylated (By similarity). Phosphorylated on

Ser-60 by protein kinase C delta type catalytic subunit in a sphingosine-dependent fashion (By similarity)¹

Isoform Short contains a N-acetylmethionine at position 1 (By similarity)¹

View modification sites using PhosphoSitePlus²

View neXtProt modification sites for NX_P31946

YWHAB Protein expression data from MOPED and PaxDb: About this image

REFSEQ proteins (2 alternative transcripts):

NP_003395.1 NP_647539.1

ENSEMBL proteins:

ENSP00000300161 ENSP00000361930 ENSP00000394729 ENSP00000394558

Reactome Protein details: P31946
Human Recombinant Protein Products:

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	OriGene Purified Proteins (see all 2): YWHAB OriGene Protein Over-expression Lysate (see all 2): YWHAB OriGene Custom Protein Services for YWHAB
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	Novus Biologicals YWHAB Proteins Novus Biologicals YWHAB Lysates
	Sino Biological Recombinant Protein for YWHAB
	ProSpec Recombinant Protein for YWHAB
	Browse Proteins at Uscn

Gene Ontology (GO): 5/8 cellular component terms (GO ID links to tree view) (see all 8): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005634	nucleus	--	--
GO:0005737	cytoplasm	IDA	--
GO:0005813	centrosome	--	--
GO:0005829	cytosol	TAS	--
GO:0017053	transcriptional repressor complex	IEA	--

YWHAB for ontologies About GeneDecksing

YWHAB Antibody Products:

	EMD Millipore Mono- and Polyclonal Antibodies for the study of YWHAB
	R&D Systems Antibodies for YWHAB (14-3-3 beta)
	OriGene Antibodies (see all 3): YWHAB OriGene Custom Antibody Services for YWHAB
	GenScript Custom Superior Antibodies Services for YWHAB
	Novus Biologicals YWHAB Antibodies
	Abcam antibodies for YWHAB
	Browse Antibodies at Uscn
	ThermoFisher Antibody for YWHAB

Assay Products for YWHAB:

	Browse Kits and Assays available from EMD Millipore
	OriGene Custom Immunoassay Development Browse OriGene Fluorogenic Cell Assay Kits
	Browse R&D Systems for biochemical assays
	GenScript Custom Assay Services for YWHAB
	Browse Enzo Life Sciences for kits & assays
	Browse ELISAs and CLIAs at Uscn

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

YWHAB for domains About GeneDecksing

3 InterPro domains/families:

IPR023410 14-3-3_domain

IPR000308 14-3-3

IPR023409 14-3-3_CS

Graphical View of Domain Structure for InterPro Entry P31946

ProtoNet protein and cluster: P31946

1 Blocks protein family: IPB000308 14-3-3 protein

UniProtKB/Swiss-Prot: 1433B_HUMAN, P31946

Similarity: Belongs to the 14-3-3 family

(According to ¹UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or ²DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
About This Section

Function Summary:

UniProtKB/Swiss-Prot: 1433B_HUMAN, P31946

Function: Adapter protein implicated in the regulation of a large spectrum of both general and specialized signaling

pathways. Binds to a large number of partners, usually by recognition of a phosphoserine or phosphothreonine motif.

Binding generally results in the modulation of the activity of the binding partner. Negative regulator of

osteogenesis. Blocks the nuclear translocation of the phosphorylated form (by AKT1) of SRPK2 and antagonizes its

stimulatory effect on cyclin D1 expression resulting in blockage of neuronal apoptosis elicited by SRPK2

Genatlas biochemistry entry for YWHAB:

tyrosine 3-monooxygenase/trytophan 5 monooxygenase activation protein,14-3-3 beta protein,including the phosphorylated

form YWHAA (alpha),multifunctional regulator involved in cell-cyle control (checkpoint) and signal

transduction,inhibitor of apoptosis through inhibiting the activation of p38 MAP kinase

miRNA Products:		OriGene 3'-UTR Clone (see all 2): YWHAB Browse MicroRNA Expression Plasmids
		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat YWHAB
		8/42 QIAGEN miScript miRNA Assays for microRNAs that regulate YWHAB (see all 42):
		hsa-miR-124* hsa-miR-4291 hsa-miR-429 hsa-miR-128 hsa-miR-759 hsa-miR-183* hsa-miR-1276 hsa-miR-200b

		SwitchGear 3'UTR luciferase reporter plasmid: YWHAB 3' UTR sequence

Inhib. RNA Products:		Browse for Gene Knock-down Tools from EMD Millipore
		OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for YWHAB (see all 7) OriGene shRNA RFP: YWHAB OriGene siRNA: YWHAB
		QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat YWHAB

Gene Editing
Products:

DNA2.0 Custom Protein Engineering Service for YWHAB

Clone Products:		Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
		OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for YWHAB (see all 4) OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for YWHAB (see all 2) OriGene custom cloning services � gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
		GenScript: all cDNA clones in your preferred vector (see all 2): YWHAB (NM_139323)
		Sino Biological Human cDNA Clone for YWHAB
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		Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat YWHAB

Cell Line Products:		GenScript Custom overexpressing Cell Line Services for YWHAB
		Search LifeMap BioReagents cell lines for YWHAB

In Situ Assay
Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for YWHAB

Gene Ontology (GO): 5/10 molecular function terms (GO ID links to tree view) (see all 10): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0003714	transcription corepressor activity	IEA	--
GO:0004497	monooxygenase activity	--	--
GO:0005515	protein binding	IPI	--
GO:0008022	protein C-terminus binding	IEA	--
GO:0019899	enzyme binding	IPI	17255105

YWHAB for ontologies About GeneDecksing

(Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to ¹UniProtKB, ²MINT, ³I2D, and/or ⁴STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
About This Section

Unified GeneCards pathways - 5/72 super-pathways (see all 72) About this table

See pathways by source

Super-pathway

contained gene-specific pathways

Signaling by FGFR

8/12 pathways (see all 12)
Signaling by FGFR	1.00	DAP12 signaling	0.83
Downstream signaling of activated FGFR	0.92	Signaling by EGFR in Cancer	0.83
Signaling by FGFR in disease	0.91	DAP12 interactions	0.76
Signaling by ERBB2	0.89	Signaling by PDGF	0.72

SHC-mediated signalling

8/10 pathways (see all 10)
SHC-mediated signalling	1.00	GRB2 events in EGFR signaling	0.71
SHC-related events	0.88	RAF/MAP kinase cascade	0.67
SHC-related events triggered by IGF1R	0.83	RAF phosphorylates MEK	0.47
SHC1 events in EGFR signaling	0.76	MEK activation	0.47

IRS-related events

IRS-related events	1.00	Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R)	0.90
IRS-mediated signalling	0.98	IGF1R signaling cascade	0.90
Insulin receptor signalling cascade	0.94	Signaling by Insulin receptor	0.74
IRS-related events triggered by IGF1R	0.93

ARMS-mediated activation

	ARMS-mediated activation	1.00			Signalling to p38 via RIT and RIN	0.72
	Prolonged ERK activation events	0.80			Frs2-mediated activation	0.70

Activation of cAMP-Dependent PKA

	Activation of cAMP-Dependent PKA	1.00			Activation of PKA through GPCR	0.71
	cAMP Pathway	0.77			PKA Signaling	0.56

Pathway sources
See GeneCards unified pathways
Show all pathways

5/7 EMD Millipore Pathways for YWHAB (see all 7)

	Cytoskeleton remodeling Role of PKA in cytoskeleton reorganisation
	Immune response Function of MEF2 in T lymphocytes
	Cell cycle Role of 14-3-3 proteins in cell cycle regulation
	G-protein signaling G-Protein alpha-12 signaling pathway
	Development Role of HDAC and calcium/calmodulin-dependent kinase (CaMK) in control of skeletal myogenesis

1 R&D Systems Pathway for YWHAB

Apoptosis Signaling Pathways

5/18 Downloadable PowerPoint Slides of QIAGEN Pathway Central Maps for YWHAB (see all 18)

	14-3-3 Induced Apoptosis
	DHA Signaling
	PKA Signaling
	ERK5 Signaling
	BDNF Pathway

4 Cell Signaling Technology (CST) Pathways for YWHAB

	MAP Kinase Signaling
	Apoptosis and Autophagy
	Cell Cycle / Checkpoint Control
	Tyrosine Kinases / Adaptors

2 Tocris Bioscience Pathways for YWHAB

	Insulin Pathway
	Apoptosis Pathway

5/7 GeneGo (Thomson Reuters) Pathways for YWHAB (see all 7)

	Apoptosis and survival BAD phosphorylation
	Development Role of HDAC and calcium/calmodulin-dependent kinase (CaMK) in control of skeletal myogenesis
	Development IGF-1 receptor signaling
	Cytoskeleton remodeling Role of PKA in cytoskeleton reorganisation
	Immune response Function of MEF2 in T lymphocytes

5/20 BioSystems Pathways for YWHAB (see all 20)

	Calcium Regulation in the Cardiac Cell
	EGFR1 Signaling Pathway
	Myometrial Relaxation and Contraction Pathways
	SIDS Susceptibility Pathways
	Alpha6-Beta4 Integrin Signaling Pathway

5/68 Reactome Pathways for YWHAB (see all 68)

	SHC-related events
	SHC-mediated signalling
	Intrinsic Pathway for Apoptosis
	IRS-mediated signalling
	Signaling by PDGF

3 Kegg Pathways (Kegg details for YWHAB):

	Cell cycle
	Oocyte meiosis
	Neurotrophin signaling pathway

YWHAB for pathways About GeneDecksing

Interactions:

SABiosciences Gene Network Central^TM Interacting Genes and Proteins Network for YWHAB

STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

5/905 Interacting proteins for YWHAB (P31946^{1, 2, 3} ENSP00000300161⁴) via UniProtKB, MINT, STRING, and/or I2D (see all 905)

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
TSC2	P49815²^,³, ENSP00000219476⁴	MINT-8009815 MINT-8006263 MINT-15978 MINT-50944 MINT-8006321 MINT-15979 MINT-17162 MINT-15977 I2D: score=6 STRING: ENSP00000219476
CDC25A	P30304¹^,²^,³, ENSP00000303706⁴	EBI-359815,EBI-747671 MINT-8004859 I2D: score=4 STRING: ENSP00000303706
CDC25B	P30305²^,³, ENSP00000245960⁴	MINT-19327 MINT-8006726 MINT-51064 MINT-51065 MINT-8007484 MINT-25122 I2D: score=5 STRING: ENSP00000245960
TPD52L1	Q16890²^,³, ENSP00000357387⁴	MINT-15934 MINT-15935 MINT-15933 I2D: score=2 STRING: ENSP00000357387
YWHAQ	P27348²^,³, ENSP00000238081⁴	MINT-7300139 MINT-7264099 MINT-7900157 I2D: score=2 STRING: ENSP00000238081

About this table

Gene Ontology (GO): 5/21 biological process terms (GO ID links to tree view) (see all 21): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0000165	MAPK cascade	TAS	--
GO:0000186	activation of MAPKK activity	TAS	--
GO:0006605	protein targeting	IEA	--
GO:0006915	apoptotic process	TAS	--
GO:0007173	epidermal growth factor receptor signaling pathway	TAS	--

YWHAB for ontologies About GeneDecksing

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
About This Section

YWHAB for compounds About GeneDecksing

Browse Small Molecules at EMD Millipore

Browse drugs & compounds from Enzo Life Sciences

Compounds for YWHAB available from Tocris Bioscience About this table

Compound	Action	CAS #
Difopein	High affinity inhibitor of 14.3.3 proteins; induces apoptosis	[396834-58-5]
R18	Inhibitor of 14.3.3 proteins; induces apoptosis	[211364-78-2]

2 HMDB Compounds for YWHAB About this table

Compound	Synonyms	CAS #	PubMed Ids
Sepiapterin	L-sepiapterin (see all 8)	17094-01-8	--
Zolpidem	Ambien (see all 7)	82626-48-0	--

1 Novoseek chemical compound relationship for YWHAB gene About this table

Compound	-log (P-Val)	Hits	PubMed IDs for Articles with Shared Sentences (# sentences)
serine	28.2	1	16469478 (1)

Search CenterWatch for drugs/clinical trials and news about YWHAB / 1433B

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from EMD Millipore,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
About This Section

REFSEQ mRNAs for YWHAB gene (2 alternative transcripts):

NM_003404.3 NM_139323.2

Unigene Cluster for YWHAB:

Tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, beta polypeptide

Hs.643544 [show with all ESTs]

Unigene Representative Sequence: AB209759

7 Ensembl transcripts including schematic representations, and UCSC links where relevant:

ENST00000353703(uc002xmu.3) ENST00000479421 ENST00000372839(uc002xmt.3)

ENST00000428262 ENST00000445830 ENST00000477896 ENST00000479758

miRNA Products:		OriGene 3'-UTR Clone (see all 2): YWHAB Browse OriGene MicroRNA Expression Plasmids
		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat YWHAB
		8/42 QIAGEN miScript miRNA Assays for microRNAs that regulate YWHAB (see all 42):
		hsa-miR-124* hsa-miR-4291 hsa-miR-429 hsa-miR-128 hsa-miR-759 hsa-miR-183* hsa-miR-1276 hsa-miR-200b

		SwitchGear 3'UTR luciferase reporter plasmid: YWHAB 3' UTR sequence

Inhib. RNA Products:		Browse for Gene Knock-down Tools from EMD Millipore
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Clone Products:		OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for YWHAB (see all 4) OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for YWHAB (see all 2) OriGene custom cloning services � gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
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Primer Products:		OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for YWHAB Browse OriGene validated miRNA SYBR primer pairs
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		QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat YWHAB
		QIAGEN QuantiFast Probe-based Assays in human, mouse, rat YWHAB

Additional cDNA sequence:

AB209759.1 AB451260.1 AB451386.1 AF064847.1 AF107406.1 AK292717.1 AL834170.1 BC001359.2

BC010352.1 X57346.1

24/43 DOTS entries (see all 43):

DT.75122682 DT.92325870 DT.100883297 DT.100883300 DT.100059833 DT.100883284 DT.87077844 DT.100883281

DT.92007444 DT.120826031 DT.95256702 DT.95118446 DT.100883292 DT.100059820 DT.100883274 DT.95151410

DT.95151426 DT.120826094 DT.91772166 DT.100883277 DT.100883289 DT.95151421 DT.100883266 DT.120826008

24/1367 AceView cDNA sequences (see all 1367):

AA113239 CA306681 W44709 AI559943 AI214594 AV713167 BQ947952 AA127557

NM_003404 W49730 W49656 AV757152 AA843760 CB134796 BM766686 AA305887

CB162977 BM765397 AA313856 BM763683 AI815029 T31374 AA070066 BM479910

GeneLoc Exon Structure

5/10 Alternative Splicing Database (ASD) splice patterns (SP) for YWHAB (see all 10) About this scheme

ExUns:	1a	·	1b	^	2	^	3a	·	3b	^	4a	·	4b	·	4c	·	4d	^	5a	·	5b	·	5c	^	6a	·	6b	^	7a	·	7b	^	8	^	9a	·	9b	·	9c
SP1:					-		-										-		-		-		-
SP2:					-		-		-								-		-		-		-
SP3:
SP4:																	-
SP5:							-

ECgene alternative splicing isoforms for YWHAB

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section

YWHAB expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: CAGTTACTTA

About this image
See YWHAB Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for YWHAB

SOURCE GeneReport for Unigene cluster: Hs.643544

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(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD , ⁵MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or ⁶Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
About This Section

This gene was present in the common ancestor of eukaryotes.

Orthologs for YWHAB gene from 8/30 species (see all 30) About this table

Organism	Taxonomic classification	Gene	Description	Human Similarity	Orthology Type	Details
chicken (Gallus gallus)	Aves	YWHAB¹	tyrosine 3-monooxygenase/tryptophan 5-monooxygenase more	84.7(n) 97.95(a)		419190 NM_001006289.1 NP_001006289.1
lizard (Anolis carolinensis)	Reptilia	YWHAB⁶	--	97(a)	1 ↔ 1	4(143599907-143603773)
African clawed frog (Xenopus laevis)	Amphibia	M86928.1²	--	79.86(n)		M86928.1
zebrafish (Danio rerio)	Actinopterygii	CA473362.1²	--	81.66(n)		323055 CA473362.1
fruit fly (Drosophila melanogaster)	Insecta	14-3-3&zgr;³	RAS protein signal transduction diacylglycerol-activated/phospholipid more	79(a)		--
worm (Caenorhabditis elegans)	Secernentea	ftt-2⁶ par-5⁶ (see all 3)	14-3-3-like protein 1 (see all 3)	78(a) 75(a) (see all 3)	possible ortholog possible ortholog (see all 3)	X(11603640-11605354) IV(11820482-11821901)
thale cress (Arabidopsis thaliana)	eudicotyledons	GRF3⁶ GRF11⁶ (see all 14)	general regulatory factor 11 (see all 14)	59(a) 58(a) (see all 14)	many ↔ many many ↔ many (see all 14)	5(15409697-15411516) 1(12743821-12745648)
rice (Oryza sativa)	Liliopsida	GF14c⁶ GF14f⁶ (see all 8)	14-3-3 protein, putative, expressed (see all 8)	59(a) 58(a) (see all 8)	many ↔ many many ↔ many (see all 8)	8(20809790-20812919) 3(28656820-28661023)

ENSEMBL Gene Tree for YWHAB (if available)
TreeFam Gene Tree for YWHAB (if available)

(Paralogs according to ¹HomoloGene,
²Ensembl, and ³SIMAP, Pseudogenes according to ⁴Pseudogene.org Build 68)
About This Section

Paralogs for YWHAB gene

YWHAE² YWHAH² YWHAQ² YWHAG² SFN² YWHAZ²

9 SIMAP similar genes for YWHAB using alignment to 4 protein entries: 1433B_HUMAN (see all proteins):

YWHAZ YWHAQ 14-3-3 protein YWHAH SFN YWHAG

YWHAE/FAM22B fusion YWHAE/FAM22A fusion YWHAE

YWHAB for paralogs About GeneDecksing

2 Pseudogenes.org Pseudogenes for YWHAB
PGOHUM00000242182 PGOHUM00000236462

(SNPs/Variants according to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section

SNP ID	Valid	Clinical significance	Chr 20 pos	Sequence	#	AA Chg	Type	More	#	Allele freq	Pop	Total sample	More
Genomic Data					Transcription Related Data				Allele Frequencies
				--	--	--		--	--
rs151064529^1,2	C,	--	43512385(+)	`ATGAC-/AGATAAC`	2	--	us2k¹		0	--	--	--	--
rs191350643^1,2		--	43512426(+)	`AAGGGA/TCCCTG`	2	--	us2k¹		0	--	--	--	--
rs183117638^1,2		--	43512526(+)	`TTACCA/TGACAA`	2	--	us2k¹		0	--	--	--	--
rs187408801^1,2		--	43512558(+)	`TCACAC/TAGAAA`	2	--	us2k¹		0	--	--	--	--
rs139216004^1,2		--	43512560(+)	`ACACAC/GAAACT`	2	--	us2k¹		0	--	--	--	--
rs192553646^1,2		--	43512679(+)	`GGGGAA/GAAATA`	2	--	us2k¹		0	--	--	--	--
rs183224684^1,2		--	43512692(+)	`AGCTAA/CAGGAT`	2	--	us2k¹		0	--	--	--	--
rs11480448^1,2	C,	--	43512852(+)	`TGAGAG/-CCAAA`	2	--	us2k¹		1		CSA	2
rs76456831^1,2	C,	--	43512854(+)	`TGAGAG/CCAAAT`	2	--	us2k¹		1		WA	2
rs192491214^1,2		--	43512976(+)	`CCACCG/TGCCTT`	2	--	us2k¹		0	--	--	--	--

HapMap Linkage Disequilibrium report for YWHAB (43514317 - 43537173 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV) variations for YWHAB: --

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(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
About This Section

YWHAB for disorders           About GeneDecksing

OMIM gene information: 601289    OMIM disorders: --

20/23 diseases for YWHAB (see all 23):    About MalaCards

williams-beuren syndrome multiple system atrophy systemic lupus erythematosus lupus erythematosus

tuberous sclerosis insulin resistance renal cell carcinoma lipodystrophy

hepatitis c bladder carcinoma hepatocellular carcinoma alzheimer's disease

seizures gastric cancer carcinoma glioblastoma

hepatitis schizophrenia immunodeficiency malaria

Genetic Association Database (GAD): YWHAB
Human Genome Epidemiology (HuGE) Navigator: YWHAB (1 document)

Export disorders for YWHAB gene to outside databases

(in PubMed. Associations of this gene to articles via ¹Entrez Gene, ²UniProtKB/Swiss-Prot, ³HGNC, ⁴GAD, ⁵PharmGKB, ⁶HMDB, ⁷DrugBank, ⁸UniProtKB/TrEMBL, ⁹ Novoseek, and/or ¹⁰fRNAdb)
About This Section

PubMed articles for YWHAB gene, integrated from 9 sources (see all 219):
(articles sorted by number of sources associating them with YWHAB)

Utopia: connect your pdf to the dynamic
world of online information

Phosphorylation-dependent binding of 14-3-3 terminates signalling by the Gab2 docking protein. (PubMed id 19172738)^{1, 2} Brummer T.... Daly R.J. (2008)
Inactivation of YAP oncoprotein by the Hippo pathway is involved in cell contact inhibition and tissue growth control. (PubMed id 17974916)^{1, 2} Zhao B.... Guan K.L. (2007)
Homodimerization of Ror2 tyrosine kinase receptor induces 14-3- 3(beta) phosphorylation and promotes osteoblast differentiation and bone formation. (PubMed id 17717073)^{1, 2} Liu Y.... Billiard J. (2007)
Proteomic and bioinformatic characterization of the biogenesis and function of melanosomes. (PubMed id 17081065)^{1, 2} Chi A....Hunt D.F. (2006)
A pathway of neuregulin-induced activation of cofilin-phosphatase Slingshot and cofilin in lamellipodia. (PubMed id 15159416)^{1, 2} Nagata-Ohashi K.... Mizuno K. (2004)
The CREB coactivator TORC2 functions as a calcium- and cAMP-sensitive coincidence detector. (PubMed id 15454081)^{1, 2} Screaton R.A.... Montminy M. (2004)
Association of a four-amino acid residue insertion polymorphism of the HS1 gene with systemic lupus erythematosus: molecular and functional analysis. (PubMed id 15022330)^{1, 4} Otsuka J....Harada M. (2004)
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)^{1, 2} Gerhard D.S....Malek J. (2004)
Exploring proteomes and analyzing protein processing by mass spectrometric identification of sorted N-terminal peptides. (PubMed id 12665801)^{1, 2} Gevaert K.... Vandekerckhove J. (2003)
The DNA sequence and comparative analysis of human chromosome 20. (PubMed id 11780052)^{1, 2} Deloukas P....Rogers J. (2001)

(in PubMed, OMIM, and NCBI Bookshelf)
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		AND	OR
Aliases
Free Text

Query String		PubMed OMIM NCBI Bookshelf
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(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
About This Section

Entrez Gene: 7529	HGNC: 12849	AceView: YWHAB	Ensembl:ENSG00000166913	euGenes: HUgn7529
ECgene: YWHAB	Kegg: 7529	H-InvDB: YWHAB

(According to HUGE)
About This Section

(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section

Name	Description
PharmGKB entry for YWHAB	Pharmacogenomics, SNPs, Pathways

Intellectual Property for YWHAB gene
(Patent information from GeneIP, Licensable technologies from WIS Yeda, Salk, Tufts, IP news from LifeMap Sciences, Inc.)

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Patent Information for YWHAB gene:
Search GeneIP for patents involving YWHAB

GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search

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