YWHAB Gene
protein-coding GIFtS : 69 GCID: GC20 P043515
Tyrosine 3-Monooxygenase/Tryptophan 5-Monooxygenase Activation... tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation... YWHAA )
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Aliasesfor YWHAB gene
(According to
1 HGNC ,
2 Entrez Gene ,
3 UniProtKB/Swiss-Prot ,
4 UniProtKB/TrEMBL , 5 OMIM , 6 GeneLoc ,
7 Ensembl ,
8 DME ,
9 miRBase ,
10 fRNAdb ,
12 H-InvDB ,
13 NCBI ,
14 NONCODE ,
and/or 15 RNAdb )About This Section Aliases Tyrosine 3-Monooxygenase/Tryptophan 5-Monooxygenase Activation Protein, BetaPolypeptide 1 2 14-3-3 Beta1 YWHAA1 2 14-3-3 Protein Beta/Alpha2 Tyrosine 3-Monooxygenase/Tryptophan 5-Monooxygenase Activation Protein, AlphaPolypeptide1 2 GW1282 14-3-3 Alpha1 2 HS12 Protein 10542 3 Brain Protein 14-3-3, Beta Isoform2 Protein Kinase C Inhibitor Protein 12 3 Protein Kinase C Inhibitor Protein-12 KCIP-12 3
Export aliases for YWHAB gene to outside databases Previous GC identifers: GC20P043242 GC20P043202 GC20P044152 GC20P044199 GC20P042947 GC20P040256
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Summariesfor YWHAB gene (According to Entrez Gene ,
Tocris Bioscience ,
Wikipedia's
Gene Wiki ,
PharmGKB ,UniProtKB/Swiss-Prot ,
and/or
UniProtKB/TrEMBL )
About This Section Entrez Gene summary for YWHAB Gene: This gene encodes a protein belonging to the 14-3-3 family of proteins, members of which mediate signal transduction by binding to phosphoserine-containing proteins. This highly conserved protein family is found in both plants and mammals. The encoded protein has been shown to interact with RAF1 and CDC25 phosphatases, suggesting that it may play a role in linking mitogenic signaling and the cell cycle machinery. Two transcript variants, which encode the same protein, have been identified for this gene. (provided by RefSeq, Jul 2008) GeneCards Summary for YWHAB Gene: YWHAB (tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, beta polypeptide) is a protein-coding gene. Diseases associated with YWHAB include tuberous sclerosis complex tuberous sclerosis related super-pathways are Cell cycle and Signal transduction AKT signaling . GO annotations related to this gene include enzyme binding and protein domain specific binding . An important paralog of this gene is YWHAH . UniProtKB/Swiss-Prot: 1433B_HUMAN, P31946 Function : Adapter protein implicated in the regulation of a large spectrum of both general and specialized signalingpathways. Binds to a large number of partners, usually by recognition of a phosphoserine or phosphothreonine motif. Binding generally results in the modulation of the activity of the binding partner. Negative regulator of osteogenesis. Blocks the nuclear translocation of the phosphorylated form (by AKT1) of SRPK2 and antagonizes its stimulatory effect on cyclin D1 expression resulting in blockage of neuronal apoptosis elicited by SRPK2 summary
for YWHAB Gene: 14.3.3 proteins are a group of highly conserved proteins that are involved in many vital cellular processessuch as metabolism, protein trafficking, signal transduction, apoptosis and cell cycle regulation. 14.3.3proteins are phospho-serine/phospho-threonine binding proteins that have a diverse array of partnersincluding transcription factors, biosynthetic enzymes, cytoskeletal proteins, signalling molecules,apoptosis factors and tumour suppressors. The 14.3.3 family consists of 7 isoforms; beta, gamma, epsilon,sigma, zeta, tau and eta. 14.3.3 proteins are ubiquitously expressed and self assemble into homo- andheterodimers, with the exception of 14.3.3sigma, which exclusively forms homodimers and is found in cells ofepithelial origin only. Each monomer contains an independent ligand-binding site, thus the 14.3.3 dimer caninteract with two target proteins simultaneously. 14.3.3 proteins are highly rigid structures and ligandbinding can induce conformational changes that alter the stability and/or catalytic activity of the ligand.Furthermore, 14.3.3 protein binding can physically occlude sequence-specific or structural motifs on thetarget that prevent molecular interactions and/or modulate the accessibility of a target protein tomodifying enzymes such as kinases, phosphatases and proteases. In addition, 14.3.3 proteins can act as ascaffold molecule to anchor target proteins within close proximity of one another. 14.3.3 proteins representan integration point for proliferative, survival, apoptotic and stress signalling pathways. Members of the14.3.3 protein family enhance the activity of many proteins with proliferative and/or survival functions,such as Raf kinases, and antagonise the activity of proteins that promote cell death and senescence, such asBad, Bim and Bax. In contrast, 14.3.3sigma acts as a tumour suppressor and its expression is upregulatedcoordinately with p53 and BRAC1. This isoform sequesters cdk1-cyclin B complexes in the cytoplasm, and thusdelays cell cycle progression. 14.3.3sigma is also a crucial regulator of translation during mitosis.Because many 14.3.3 interactions are phosphorylation dependent, 14.3.3 proteins have been integrated intothe core regulatory pathways that are crucial for normal growth and development. 14.3.3 proteins aredirectly involved in cellular processes such as cytokinesis, cell-contact inhibition, anchorage-independentgrowth and cell adhesion, and it is these pathways that often become dysregulated in disease states such ascancer. Gene Wiki entry for YWHAB Gene
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Genomic Viewsfor YWHAB gene
(According to
GeneLoc and/or
HGNC , and/or
Entrez Gene (NCBI build 37) ,miRBase ,UCSC (hg19) and
Ensembl (release 73) ,
Regulatory elements and Epigenetics data according to
QIAGEN ,
SABiosciences , and/or
SwitchGear Genomics )About This Section RefSeq DNA sequence: NC_000020.10 NT_011362.10 NC_018931.2 Regulatory elements: SABiosciences Regulatory transcription factor binding sites in the YWHAB gene promoter:MEF-2 E47 CREB MEF-2A POU2F1 FOXJ2 (long isoform) POU2F1a Hand1 FOXJ2 aMEF-2 Other transcription factors Search SABiosciences Chromatin IP Primers for YWHAB Epigenetics: QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat YWHAB
Genomic Location: Genomic View : UCSC Golden Path with GeneCards custom track Entrez Gene cytogenetic band: 20q13.1 Ensembl cytogenetic band: 20q13.12 HGNC cytogenetic band: 20q13.1 YWHAB Gene in genomic location: bands according to Ensembl, locations according to
Entrez Gene Ensembl GeneLoc information about chromosome 20 GeneLoc Exon Structure
GeneLoc location for GC20P043515: view genomic region
(about GC identifiers )
Start: 43,514,317 bp from pter End:
43,537,173 bp from pter
Size: 22,857 bases Orientation:
plus strand
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Proteinsfor YWHAB gene
(According to
UniProtKB ,
HORDE ,
neXtProt ,
Ensembl ,
and/or Reactome ,
Modification sites according to PhosphoSitePlus ,
Specific Peptides from DME ,
Protein expression images according to data from SPIRE 1 MOPED ,
2 PaxDb , and 3 MAXQB
RefSeq according to NCBI ,
PDB rendering according to OCA and/or Proteopedia ,
Recombinant Proteins
from
EMD Millipore ,
R&D Systems ,
GenScript ,
Enzo Life Sciences ,
OriGene ,
Novus Biologicals ,
Sino Biological ,
ProSpec , and/or
Cloud-Clone Corp. ,
EMD Millipore ,
R&D Systems ,
OriGene ,
GenScript ,
Cell Signaling Technology ,
Enzo Life Sciences , and/or
Cloud-Clone Corp. ,
Ontologies according to Gene
Ontology Consortium 01 Oct 2013 and
Entrez Gene ,
Antibodies by
EMD Millipore ,
R&D Systems ,
GenScript ,
Cell Signaling Technology ,
OriGene ,
Novus Biologicals ,
Thermo Fisher Scientific ,
LSBio ,
Abcam , and/or
Cloud-Clone Corp. )
About This Section UniProtKB/Swiss-Prot: 1433B_HUMAN, P31946 See
protein sequence )Recommended Name: Size : 246 amino acids; 28082 DaSubunit : Homodimer. Interacts with SAMSN1 and KRPCE (By similarity). Interacts with SSH1 and TORC2/CRTC2. Interactswith ABL1; the interaction results in cytoplasmic location of ABL1 and inhibition of cABL-mediated apoptosis. Interacts with ROR2 (dimer); the interaction results in phosphorylation of YWHAB on tyrosine residues. Interacts with GAB2 and YAP1 (phosphorylated form). Interacts with the phosphorylated (by AKT1) form of SRPK2. Interacts with PKA-phosphorylated AANAT
Subcellular location : Cytoplasm. Melanosome. Note=Identified by mass spectrometry in melanosome fractions from stage Ito stage IV
3 PDB 3D structures from :2BQ0 (3D) 2C23 (3D) 4DNK (3D) Secondary accessions : A8K9K2 E1P616Alternative initiation : 2 isoforms : P31946-1 P31946-2 (Contains a N-acetylmethionine at position 1 (By similarity))Explore the universe of human proteins at neXtProt for YWHAB: NX_P31946 Explore proteomics data for YWHAB at MOPED Post-translational modifications:
UniProtKB: The alpha, brain-specific form differs from the beta form in being phosphorylated (By similarity). Phosphorylated on Ser-60 by protein kinase C delta type catalytic subunit in a sphingosine-dependent fashion (By similarity)
UniProtKB: Isoform Short contains a N-acetylmethionine at position 1 (By similarity) View modification sites using PhosphoSitePlus View neXtProt modification sites for NX_P31946 YWHAB Protein expression data from MOPED1 2 3 : About this image REFSEQ proteins (2 alternative transcripts): NP_003395.1 NP_647539.1 ENSEMBL proteins: ENSP00000300161 ENSP00000361930 ENSP00000394729 ENSP00000394558 Reactome Protein details: P31946 Human Recombinant Protein Products for YWHAB: Gene Ontology (GO): 5/9 cellular component terms (GO ID links to tree view) (see all 9 ): About this table
About GeneDecksing YWHAB Antibody Products: Assay Products for YWHAB:
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Protein
Domains /for YWHAB gene (According to HGNC , IUPHAR , InterPro , ProtoNet ,
UniProtKB , and/or BLOCKS ,
Sets of similar genes according to GeneDecks )
About This Section 3 InterPro protein domains :
Graphical View of Domain Structure for InterPro Entry P31946 ProtoNet protein and cluster: P31946
1 Blocks protein domain : IPB000308 UniProtKB/Swiss-Prot: 1433B_HUMAN, P31946 Similarity : Belongs to the 14-3-3 familyAbout GeneDecksing
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Functionfor YWHAB gene
(According to 1 UniProtKB ,
Genatlas ,
LifeMap Discovery™ ,
IUBMB , and/or
2 DME ,
Human phenotypes from GenomeRNAi ,
Animal models from MGI Mar 06 2013,
inGenious Targeting Laboratory ,
SABiosciences ,
miRNA Gene Targets from miRTarBase ,
shRNA from
OriGene ,
Sirion Biotech ,
RNAi from
EMD Millipore ,
siRNAs from
OriGene ,
QIAGEN ,
microRNA from QIAGEN ,
Gene Editing from DNA2.0 ,
Sirion Biotech ,
Clones from EMD Millipore ,
OriGene ,
SwitchGear Genomics ,
GenScript ,
Sino Biological ,
DNA2.0 ,
and Vector BioLabs ,
Cell Lines from GenScript ,
LifeMap BioReagents ,
Sirion Biotech ,
In Situ Hybridization Assays from Advanced Cell Diagnostics ,
Ontologies according to Gene Ontology Consortium 01 Oct 2013 via
Entrez Gene .)
About This Section Molecular Function: UniProtKB/Swiss-Prot Summary: 1433B_HUMAN, P31946 Function : Adapter protein implicated in the regulation of a large spectrum of both general and specialized signalingpathways. Binds to a large number of partners, usually by recognition of a phosphoserine or phosphothreonine motif. Binding generally results in the modulation of the activity of the binding partner. Negative regulator of osteogenesis. Blocks the nuclear translocation of the phosphorylated form (by AKT1) of SRPK2 and antagonizes its stimulatory effect on cyclin D1 expression resulting in blockage of neuronal apoptosis elicited by SRPK2
Genatlas biochemistry entry for YWHAB tyrosine 3-monooxygenase/trytophan 5 monooxygenase activation protein,14-3-3 beta protein,including the phosphorylated form YWHAA (alpha),multifunctional regulator involved in cell-cyle control (checkpoint) and signal transduction,inhibitor of apoptosis through inhibiting the activation of p38 MAP kinase Gene Ontology (GO): 5/9 molecular function terms (GO ID links to tree view) (see all 9 ): About this table
About GeneDecksing Animal Models: In Situ AssayAdvanced Cell Diagnostics RNAscope RNA in situ hybridization assays for YWHAB
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Pathways & Interactionsfor YWHAB gene
(Pathways according to
EMD Millipore ,
R&D Systems ,
Cell Signaling Technology ,
KEGG ,
PharmGKB ,
BioSystems ,
Sino Biological ,
Reactome ,
Tocris Bioscience ,
GeneGo (Thomson Reuters) ,
QIAGEN ,
and/or UniProtKB ,
Sets of similar genes according to GeneDecks ,
Interaction Networks according to
SABiosciences ,
and/or STRING ,
Interactions according to 1 UniProtKB ,
2 MINT ,
3 I2D , and/or
4 STRING ,
with links to IntAct and
Ensembl ,
Ontologies according to Gene Ontology Consortium 01 Oct 2013 via
Entrez Gene) .
About This Section SuperPaths for YWHAB About (see all 76 ) See pathways by source SuperPath Selected contained pathways About (see all per SuperPath ) 1 Cell cycle 2 Development IGF-RI signaling 3 Cell cycle Role of 14-3-3 proteins in cell cycle regulation 4 Development Dopamine D2 receptor transactivation of EGFR 5 Signaling by FGFR
Pathways by source See SuperPaths Show all pathways 5/7 (see all 7 )1 5/18 (see all 18 )4 2 5/7 (see all 7 )5/20 (see all 20 )5/70 (see all 70 )5/7 (Kegg details for YWHAB) (see all 7 ):About GeneDecksing Interactions: SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for YWHAB STRING Interaction
Network Preview (showing 5 interactants - click image to see 25)5/944 Interacting proteins for YWHAB (P31946 1 , 2 , 3 ENSP00000300161 4 via UniProtKB, MINT, STRING , and/or I2D (see all 944 )About this table Gene Ontology (GO): 5/24 biological process terms (GO ID links to tree view) (see all 24 ): About this table
About GeneDecksing
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Drugs & Compoundsfor YWHAB gene (Chemical Compounds according to UniProtKB , Enzo Life Sciences ,
EMD Millipore , Tocris Bioscience
HMDB ,
BitterDB , and/or
Novoseek , and Drugs according to
DrugBank ,
IUPHAR ,
Enzo Life Sciences , and/or
PharmGKB , with drugs/clinical trials/news
search links to CenterWatch )
About This Section About GeneDecksing Compounds for YWHAB available from Tocris Bioscience About this table Compound Action
CAS
# Difopein High affinity inhibitor of 14.3.3 proteins; induces apoptosis [396834-58-5] R18 Inhibitor of 14.3.3 proteins; induces apoptosis [211364-78-2]
2 HMDB Compounds for YWHAB About this table 1 Novoseek inferred chemical compound relationship for YWHAB gene About this table
Compound
-log (P-Val)
Hits
PubMed IDs for Articles with Shared Sentences (# sentences)
serine
28.2
1
16469478 (1)
YWHAB / 1433B
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Transcriptsfor YWHAB gene (Secondary structures according to
fRNAdb ,Unigene
(Build 236 Homo sapiens; Apr 25 2013) or GenBank , Entrez Gene ,
DOTS (version 10), and/or
AceView ,
transcript ids from Ensembl
with links to UCSC , KenesGroup ,
exon structure from GeneLoc ,
alternative splicing isoforms according to ASD and/or
ECgene ,EMD Millipore ,
OriGene ,
QIAGEN ,
shRNA from
OriGene ,
Sirion Biotech ,
microRNA from QIAGEN ,
OriGene ,
SwitchGear Genomics ,
GenScript ,
DNA2.0 ,
Vector BioLabs ,
Primers from
OriGene ,
SABiosciences , and/or
QIAGEN
)About This Section REFSEQ mRNAs for YWHAB gene (2 alternative transcripts): NM_003404.4 NM_139323.3 Unigene Cluster for YWHAB:
Tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, beta polypeptide Hs.643544 [show with all ESTs ] Unigene Representative Sequence: AB209759 7 Ensembl transcripts including schematic representations, and UCSC links where relevant : ENST00000353703 (uc002xmu.3 ) ENST00000479421 ENST00000372839 (uc002xmt.3 )ENST00000428262 ENST00000445830 ENST00000477896 ENST00000479758 Primer YWHAB human mouse SABiosciences RT2 qPCR Primer Assay in human mouse rat QIAGEN QuantiTect SYBR Green Assays in human mouse rat QIAGEN QuantiFast Probe-based Assays in human mouse rat
Additional mRNA sequence: AB209759.1 AB451260.1 AB451386.1 AF064847.1 AF107406.1 AK292717.1 AL834170.1 BC001359.2 BC010352.1 X57346.1
24/49 DOTS entries (see all 49 ): DT.75122682 DT.100883284
DT.87077844 DT.100883297 DT.92325870 DT.100883281 DT.100883300 DT.100059833 DT.92007444 DT.95256702 DT.120826031 DT.100883289 DT.95118446 DT.95151426 DT.100883292 DT.120826074 DT.100883274 DT.100059820 DT.95151410 DT.120826094 DT.91772166 DT.100883277 DT.95151421 DT.100883266 24/1367 AceView cDNA sequences (see all 1367 ):
CA950124 BM825717 BQ183152 BI870517 BM761438 BF718564 CB120809 AA075401 AA872095 BM839917 BM504251 BI838277 AW087348 N26423 BM552049 AA160338 AA845374 CB141648 BM464306 BM826353 BQ889847 T39564 AW511042 BM796664 GeneLoc Exon Structure 5/10 Alternative Splicing Database (ASD) splice patterns (SP) for YWHAB (see all 10 ) About this scheme ExUns: 1a · 1b ^ 2 ^ 3a · 3b ^ 4a · 4b · 4c · 4d ^ 5a · 5b · 5c ^ 6a · 6b ^ 7a · 7b ^ 8 ^ 9a · 9b · 9c SP1 : - - - - - - SP2 : - - - - - - - SP3 : SP4 : - SP5 : -
ECgene alternative splicing isoforms for YWHAB
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Expression for YWHAB gene
(RNA expression data according to
H-InvDB ,
NONCODE ,
miRBase , and
RNAdb ,
Expression images according to data from
BioGPS ,
Illumina Human BodyMap , and
CGAP
SAGE ,
Sets of similar genes according to GeneDecks ,
in vivo and in vitro expression data from LifeMap Discovery™ ,
plus additional links to
Genevestigator , and/or
SOURCE , and/or
BioGPS , and/or
UniProtKB ,SABiosciences ,
Primers from
OriGene ,
SABiosciences , and/or
QIAGEN ,
In Situ Hybridization Assays from Advanced Cell Diagnostics )
About This Section YWHAB expression in normal human tissues
(normalized intensities) YWHAB embryonic expression: see See probesets specificity/sensitivity at GeneAnnot About this image BioGPS 2/3 CGAP TAG: CAGTTACTTAAbout this image
YWHAB expression in embryonic tissues and stem cells About this table LifeMap ,
the Embryonic Development and Stem Cells Database 5/27 selected tissues (see all 27 ) fully expand See YWHAB Protein Expression from SPIRE MOPED and PaxDB Genevestigator expression for YWHAB SOURCE GeneReport for Unigene cluster: Hs.643544 SABiosciences Custom PCR Arrays for YWHAB Primer YWHAB human mouse SABiosciences RT2 qPCR Primer Assay in human mouse rat QIAGEN QuantiTect SYBR Green Assays in human mouse rat QIAGEN QuantiFast Probe-based Assays in human mouse rat In Situ Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for YWHAB
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Orthologsfor YWHAB gene
(Orthologs according to
1,2 HomoloGene (2 older version, for species not in 1 newer version),
3 euGenes ,
4 SGD
,
5 MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase ,
and/or
6 Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam )
About This Section Orthologs for YWHAB gene from 7/16 species (see all 16 ) About this table
Organism
Taxonomic
Gene
Description
Human
Orthology
Details
mouse Mammalia Ywhab1 5
tyrosine 3-monooxygenase/tryptophan 5-monooxygenase more 1, 5
90.65(n) 1 98.78(a) 1
2 (84.59 cM) 5 54401 1 NM_018753.6 1 NP_061223.2 1 163994960 5
chicken Aves YWHAB1
tyrosine 3-monooxygenase/tryptophan 5-monooxygenase more
84.7(n) 97.95(a)
419190 NM_001006289.1 NP_001006289.1
lizard Reptilia YWHAB6
Uncharacterized protein
97(a)
1 ↔ 1
4(143599734-143603777)
African clawed frog Amphibia M86928.12
--
79.86(n)
M86928.1
zebrafish Actinopterygii CA473362.12
--
81.66(n)
323055 CA473362.1
fruit fly Insecta 14-3-3&zgr;3
RAS protein signal transduction
79(a)
--
worm Secernentea ftt-26 6
14-3-3-like protein 1
78(a) 75(a)
many ↔ manymany ↔ many
X(11603707-11605421) IV(11820505-11821924)
ENSEMBL Gene Tree for YWHAB (if available)TreeFam Gene Tree for YWHAB (if available)
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Paralogsfor YWHAB gene (Paralogs according to
1 HomoloGene ,2 Ensembl , and 3 SIMAP , Pseudogenes according to 4 Pseudogene.org Build 68)About This Section Paralogs for YWHAB gene YWHAH 2 YWHAE 2 YWHAQ 2 YWHAG 2 SFN 2 YWHAZ 2 9 SIMAP similar genes for YWHAB using alignment to 4 protein entries: 1433B_HUMAN (see all proteins ):YWHAZ YWHAQ 14-3-3 protein YWHAH SFN YWHAG YWHAE/FAM22B fusion YWHAE/FAM22A fusion YWHAE About GeneDecksing 2 Pseudogenes.org Pseudogenes for YWHAB PGOHUM00000242182 PGOHUM00000236462
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Genomic Variantsfor YWHAB gene (SNPs/Variants according to the
1 NCBI SNP Database ,
2 Ensembl ,
3 PupaSUITE ,
4 UniProtKB , and
DNA2.0 ,
Linkage Disequilibrium by HapMap ,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants , Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB) , Blood group antigen gene mutations by BGMUT ,
Resequencing Primers from QIAGEN ,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences )
About This Section Genomic Data Transcription Related Data Allele Frequencies SNP ID Valid Clinical Chr 20 pos Sequence # AA Type More # Allele Pop Total More
HapMap Linkage Disequilibrium report for YWHAB (43514317 - 43537173 bp)
Structural Variations Database of Genomic Variants (DGV) 1 variation for YWHAB : About this table SABiosciences Cancer Mutation PCR Assays
QIAGEN SeqTarget long-range PCR primers in human mouse rat
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Disorders
/ Diseasesfor YWHAB gene
(in which this Gene is Involved, According to MalaCards ,
OMIM, UniProtKB ,
the University of Copenhagen DISEASES
database , Conferences by KenesGroup ,
Genatlas , GeneTests ,
GAD ,
HuGE Navigator ,
and/or TGDB .)
About This Section About GeneDecksing OMIM gene information: 601289
OMIM disorders : --20/21 (see all 21 ): About MalaCards tuberous sclerosis complex tuberous sclerosis multiple system atrophy williams-beuren syndrome lipodystrophy bladder carcinoma insulin resistance systemic lupus erythematosus lupus erythematosus renal cell carcinoma glioblastoma hepatitis c schizophrenia gastric cancer alzheimer's disease hepatocellular carcinoma colorectal cancer hepatitis prostate cancer prostatitis Congresses - knowledge worth sharing: Alzheimer's & Parkinson's Diseases Congress (ADPD) 18 - 22 March 2015 Genetic Association Database (GAD): YWHAB Human Genome Epidemiology (HuGE) Navigator: YWHAB (1 document)Export disorders for YWHAB gene to outside databases
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Publicationsfor YWHAB gene (in
PubMed .
Associations of this gene to articles via
1 Entrez Gene ,
2 UniProtKB/Swiss-Prot ,
3 HGNC ,
4 GAD ,
5 PharmGKB ,
6 HMDB ,
7 DrugBank ,
8 UniProtKB/TrEMBL ,
9 Novoseek , and/or
10 fRNAdb )
About This Section PubMed articles for YWHAB gene, integrated from 9 sources (see all 246 ):(articles sorted by number of sources associating them with YWHAB) Utopia : connect your pdf to the dynamic
Phosphorylation-dependent binding of 14-3-3 terminates signalling by the Gab2 docking protein. (PubMed id 19172738) 1 , 2 (2008) Examination of association to autism of common genetic variationin genes related to dopamine. (PubMed id 19360691) 1 , 4(2008) Inactivation of YAP oncoprotein by the Hippo pathway is involved in cell contact inhibition and tissue growth control. (PubMed id 17974916) 1 , 2 (2007) Homodimerization of Ror2 tyrosine kinase receptor induces 14-3- 3(beta) phosphorylation and promotes osteoblast differentiation and bone formation. (PubMed id 17717073) 1 , 2 (2007) Proteomic and bioinformatic characterization of the biogenesis and function of melanosomes. (PubMed id 17081065) 1 , 2 (2006) A pathway of neuregulin-induced activation of cofilin-phosphatase Slingshot and cofilin in lamellipodia. (PubMed id 15159416) 1 , 2 (2004) The CREB coactivator TORC2 functions as a calcium- and cAMP-sensitive coincidence detector. (PubMed id 15454081) 1 , 2 (2004) Association of a four-amino acid residue insertion polymorphism of the HS1 gene with systemic lupus erythematosus: molecular and functional analysis. (PubMed id 15022330) 1 , 4(2004) The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334) 1 , 2 (2004) Exploring proteomes and analyzing protein processing by mass spectrometric identification of sorted N-terminal peptides. (PubMed id 12665801) 1 , 2 (2003)
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External Searches for YWHAB gene
(in PubMed ,
OMIM , and NCBI Bookshelf ) About This Section
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Genome Databases showing YWHAB gene
(According to
Entrez Gene ,
HGNC ,
AceView ,
euGenes ,
Ensembl ,
miRBase ,
ECgene ,
Kegg ,
and/or
H-InvDB )
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Other Databases showing YWHAB gene
(According to HUGE )
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Specialized Databases showing YWHAB gene (According to PharmGKB ,
ATLAS , HORDE , IMGT , LEIDEN , UniProtKB/Swiss-Prot , and/or UniProtKB/TrEMBL ,Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot )About This Section
Name Description PharmGKB entry for YWHAB Pharmacogenomics, SNPs, Pathways
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About This Section Patent Information for YWHAB gene: YWHAB GeneCards and IP: Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
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Productsfor YWHAB gene (Antibodies, recombinant proteins, and assays from EMD Millipore , R&D Systems , OriGene , QIAGEN , GenScript , Cell Signaling Technology , SABiosciences , Novus Biologicals , Sino Biological , Enzo Life Sciences , Abcam , ProSpec , Cloud-Clone Corp. , Thermo Fisher Scientific , LSBio , Gene Editing from DNA2.0 and Sirion Biotech , Clones from EMD Millipore , OriGene , GenScript , Sino Biological , DNA2.0 , SwitchGear Genomics , Vector BioLabs , Cell lines from GenScript , LifeMap BioReagents , and Sirion Biotech , PCR Arrays from SABiosciences , Drugs and/or compounds from EMD Millipore , Tocris Bioscience , and/or
Enzo Life Sciences , In Situ Hybridization Assays from Advanced Cell Diagnostics , Animal models from inGenious Targeting Laboratory )About This Section
QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat YWHAB QIAGEN SeqTarget long-range PCR primers in human mouse rat QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat YWHAB QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human mouse rat QIAGEN QuantiFast Probe-based Assays in human mouse rat QIAGEN QuantiTect SYBR Green Assays in human mouse rat
Tocris compounds for YWHAB
Recombinant Protein for YWHAB
Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for YWHAB
ThermoFisher Antibody for YWHAB
Vector BioLabs ready-to-use adenovirus/AAV for human , mouse , rat YWHAB
LSBio Antibodies in human mouse rat
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summary
for 
and Proteopedia 
for YWHAB:
Cell Signaling Technology (CST) Pathways for YWHAB
