Aliases for YWHAB Gene
Aliases for YWHAB Gene
- Tyrosine 3-Monooxygenase/Tryptophan 5-Monooxygenase Activation Protein Beta 2 3
- Tyrosine 3-Monooxygenase/Tryptophan 5-Monooxygenase Activation Protein, Alpha Polypeptide 2 3
- Tyrosine 3-Monooxygenase/Tryptophan 5-Monooxygenase Activation Protein, Beta Polypeptide 2 3
- Protein Kinase C Inhibitor Protein 1 3 4
- 14-3-3 Alpha 2 3
- Protein 1054 3 4
- KCIP-1 3 4
- Tyrosine 3-Monooxygenase/Tryptophan 5-Monooxygenase Activation Protein, Beta 5
- Protein Kinase C Inhibitor Protein-1 3
External Ids for YWHAB Gene
- HGNC: 12849
- Entrez Gene: 7529
- Ensembl: ENSG00000166913
- OMIM: 601289
- UniProtKB: P31946
Previous HGNC Symbols for YWHAB Gene
- YWHAA
Previous GeneCards Identifiers for YWHAB Gene
- GC20P043242
- GC20P043202
- GC20P044152
- GC20P044199
- GC20P042947
- GC20P043515
- GC20P040256
Summaries for YWHAB Gene
-
This gene encodes a protein belonging to the 14-3-3 family of proteins, members of which mediate signal transduction by binding to phosphoserine-containing proteins. This highly conserved protein family is found in both plants and mammals. The encoded protein has been shown to interact with RAF1 and CDC25 phosphatases, suggesting that it may play a role in linking mitogenic signaling and the cell cycle machinery. Two transcript variants, which encode the same protein, have been identified for this gene. [provided by RefSeq, Jul 2008]
GeneCards Summary for YWHAB Gene
YWHAB (Tyrosine 3-Monooxygenase/Tryptophan 5-Monooxygenase Activation Protein Beta) is a Protein Coding gene. Diseases associated with YWHAB include Creutzfeldt-Jakob Disease and Gerstmann-Straussler Disease. Among its related pathways are Negative regulation of MAPK pathway and Cell Cycle Checkpoints. GO annotations related to this gene include enzyme binding and protein complex binding. An important paralog of this gene is YWHAZ.
UniProtKB/Swiss-Prot for YWHAB Gene
-
Adapter protein implicated in the regulation of a large spectrum of both general and specialized signaling pathways. Binds to a large number of partners, usually by recognition of a phosphoserine or phosphothreonine motif. Binding generally results in the modulation of the activity of the binding partner. Negative regulator of osteogenesis. Blocks the nuclear translocation of the phosphorylated form (by AKT1) of SRPK2 and antagonizes its stimulatory effect on cyclin D1 expression resulting in blockage of neuronal apoptosis elicited by SRPK2.
-
14.3.3 proteins are a group of highly conserved proteins that are involved in many vital cellular processes such as metabolism, protein trafficking, signal transduction, apoptosis and cell cycle regulation. 14.3.3 proteins are phospho-serine/-threonine binding proteins.
No data available for PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for YWHAB Gene
Genomics for YWHAB Gene
Regulatory Elements for YWHAB Gene
Enhancers for YWHAB Gene
| GeneHancer Identifier | Score | Enhancer Sources | TSS distance (kb) | Number of Genes Away | Size (kb) | Transcription Factor Binding Sites within enhancer | Other Gene Targets for Enhancer |
|---|
Enhancers around YWHAB on UCSC Golden Path with GeneCards custom track
Promoters for YWHAB Gene
| Ensembl Regulatory Elements (ENSRs) | TSS Distance (bp) | Size (bp) | Binding Sites for Transcription Factors within promoters |
|---|
ENSRs around YWHAB on UCSC Golden Path with GeneCards custom track
- Transcription factor binding sites by QIAGEN in the YWHAB gene promoter:
Regulatory Element Products
Genomic Location for YWHAB Gene
- Chromosome:
- 20
- Start:
- 44,885,599 bp from pter
- End:
- 44,908,532 bp from pter
- Size:
- 22,934 bases
- Orientation:
- Plus strand
Genomic View for YWHAB Gene
Genes around YWHAB on UCSC Golden Path with GeneCards custom track
- Cytogenetic band:
-
- 20q13.12 by Ensembl
- 20q13.1 by Entrez Gene
- 20q13.1 by HGNC
YWHAB Gene in genomic location: bands according to
Ensembl, locations according to GeneLoc
(and/or Entrez Gene and/or Ensembl if different)
Genomic Neighborhood
• Exon Structure
• Gene Density
RefSeq DNA sequence for YWHAB Gene
Proteins for YWHAB Gene
-
Protein details for YWHAB Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- P31946-1433B_HUMAN
- Recommended name:
- 14-3-3 protein beta/alpha
- Protein Accession:
- P31946
- A8K9K2
- E1P616
Protein attributes for YWHAB Gene
- Size:
- 246 amino acids
- Molecular mass:
- 28082 Da
- Quaternary structure:
-
- Homodimer. Interacts with SAMSN1 and PRKCE (By similarity). Interacts with SSH1 and TORC2/CRTC2. Interacts with ABL1; the interaction results in cytoplasmic location of ABL1 and inhibition of cABL-mediated apoptosis. Interacts with ROR2 (dimer); the interaction results in phosphorylation of YWHAB on tyrosine residues. Interacts with GAB2 and YAP1 (phosphorylated form). Interacts with the phosphorylated (by AKT1) form of SRPK2. Interacts with PKA-phosphorylated AANAT. Interacts with MYO1C and SIRT2. Interacts with herpes simplex virus 1 protein UL46. Interacts with the Thr-369 phosphorylated form of DAPK2 (PubMed:26047703).
Protein Expression for YWHAB Gene
Post-translational modifications for YWHAB Gene
- Isoform Short contains a N-acetylmethionine at position 1.
- The alpha, brain-specific form differs from the beta form in being phosphorylated. Phosphorylated on Ser-60 by protein kinase C delta type catalytic subunit in a sphingosine-dependent fashion.
- Ubiquitination at Lys 11, Lys 117, and Lys 140
- Modification sites at PhosphoSitePlus
Other Protein References for YWHAB Gene
- ENSEMBL proteins:
- REFSEQ proteins:
Antibody Products
- EMD Millipore Complete listing of Mono and Polychlonal Antibodies for YWHAB
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- antibodies-online Antibodies for YWHAB: See all 130
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-
Santa Cruz Biotechnology (SCBT) Antibodies for YWHAB
Protein Products
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- antibodies-online Proteins for YWHAB: See all 7
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- Search GeneTex for Proteins for YWHAB
Assay Products
- antibodies-online Kits for YWHAB: See all 8
No data available for DME Specific Peptides for YWHAB Gene
Domains & Families for YWHAB Gene
Gene Families for YWHAB Gene
Protein Domains for YWHAB Gene
- InterPro:
- Blocks:
- ProtoNet:
Suggested Antigen Peptide Sequences for YWHAB Gene
- GenScript: Design optimal peptide antigens:
Graphical View of Domain Structure for InterPro Entry
P31946- Family:
-
- Belongs to the 14-3-3 family.
Function for YWHAB Gene
Molecular function for YWHAB Gene
- GENATLAS Biochemistry:
- tyrosine 3-monooxygenase/trytophan 5 monooxygenase activation protein,14-3-3 beta protein,including the phosphorylated form YWHAA (alpha),multifunctional regulator involved in cell-cyle control (checkpoint) and signal transduction,inhibitor of apoptosis through inhibiting the activation of p38 MAP kinase
- UniProtKB/Swiss-Prot Function:
- Adapter protein implicated in the regulation of a large spectrum of both general and specialized signaling pathways. Binds to a large number of partners, usually by recognition of a phosphoserine or phosphothreonine motif. Binding generally results in the modulation of the activity of the binding partner. Negative regulator of osteogenesis. Blocks the nuclear translocation of the phosphorylated form (by AKT1) of SRPK2 and antagonizes its stimulatory effect on cyclin D1 expression resulting in blockage of neuronal apoptosis elicited by SRPK2.
Phenotypes for YWHAB Gene
- GenomeRNAi human phenotypes for YWHAB:
Animal Model Products
- Taconic Biosciences: Generate A Custom CRISPR Mouse Model For Your Study
-
ViGene Biosciences lentiviral particle packaged cDNA for YWHAB gene
-
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CRISPR Products
-
OriGene CRISPR knockouts for YWHAB
-
Santa Cruz Biotechnology (SCBT) CRISPR for YWHAB
- GenScript: Design CRISPR guide RNA sequences for YWHAB
miRNA for YWHAB Gene
- miRTarBase miRNAs that target YWHAB
-
- hsa-mir-1301-3p (MIRT035990)
- hsa-mir-877-3p (MIRT037014)
- hsa-mir-378a-5p (MIRT044012)
- hsa-mir-221-3p (MIRT046917)
- hsa-mir-218-5p (MIRT439267)
- hsa-mir-627-3p (MIRT505094)
- hsa-mir-6758-3p (MIRT505095)
- hsa-mir-5094 (MIRT505096)
- hsa-mir-513c-3p (MIRT505097)
- hsa-mir-513a-3p (MIRT505098)
- hsa-mir-3606-3p (MIRT505099)
- hsa-mir-551b-5p (MIRT505100)
- hsa-mir-148b-3p (MIRT505101)
- hsa-mir-148a-3p (MIRT505102)
- hsa-mir-152-3p (MIRT505103)
- hsa-mir-744-3p (MIRT529358)
- hsa-mir-620 (MIRT529359)
- hsa-mir-1270 (MIRT529360)
- hsa-mir-4423-5p (MIRT529361)
- hsa-mir-6501-5p (MIRT529362)
- hsa-mir-143-5p (MIRT529363)
- hsa-mir-4430 (MIRT529364)
- hsa-mir-3652 (MIRT529365)
- hsa-mir-122-5p (MIRT529366)
- hsa-mir-504-3p (MIRT529367)
- hsa-mir-4683 (MIRT529368)
- hsa-mir-3135b (MIRT529369)
- hsa-mir-6088 (MIRT529370)
- hsa-mir-4770 (MIRT529371)
- hsa-mir-143-3p (MIRT529372)
- hsa-mir-4781-3p (MIRT529373)
- hsa-mir-4457 (MIRT641784)
- hsa-mir-7850-5p (MIRT706790)
- hsa-mir-4531 (MIRT706791)
miRNA Products
- Search ViGene Biosciences for YWHAB
Clone Products
- OriGene clones in human for YWHAB
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Cell Line Products
-
ViGene Biosciences adenoviral particle packaged cDNA for YWHAB gene
-
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Flow Cytometry Products
No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for YWHAB Gene
Localization for YWHAB Gene
Subcellular locations from UniProtKB/Swiss-Prot for YWHAB Gene
- Cytoplasm. Melanosome. Note=Identified by mass spectrometry in melanosome fractions from stage I to stage IV.
| Compartment | Confidence |
|---|---|
| cytosol | 5 |
| extracellular | 5 |
| mitochondrion | 4 |
| nucleus | 4 |
| cytoskeleton | 1 |
| endoplasmic reticulum | 1 |
| golgi apparatus | 1 |
| plasma membrane | 1 |
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0005737 | cytoplasm | IEA,IDA | 10869435 |
| GO:0030659 | cytoplasmic vesicle membrane | TAS | -- |
| GO:0042470 | melanosome | IEA | -- |
Pathways & Interactions for YWHAB Gene
More details on SuperPathways for YWHAB| Superpath | Contained pathways | ||
|---|---|---|---|
| 1 | Interleukin-3, 5 and GM-CSF signaling |
.95
|
|
| 2 | Activation of cAMP-Dependent PKA |
.77
|
.56
|
| 3 | mTOR signalling |
.70
|
.51
|
| 4 | Activation of BH3-only proteins | ||
| 5 | Immune System |
.52
|
Pathways by source for YWHAB Gene
2 GeneTex pathways for YWHAB Gene
4 Cell Signaling Technology pathways for YWHAB Gene
20 BioSystems pathways for YWHAB Gene
93 Reactome pathways for YWHAB Gene
7 KEGG pathways for YWHAB Gene
7 GeneGo (Thomson Reuters) pathways for YWHAB Gene
- Apoptosis and survival BAD phosphorylation
- Cell cycle Role of 14-3-3 proteins in cell cycle regulation
- Cytoskeleton remodeling Role of PKA in cytoskeleton reorganisation
- Development IGF-1 receptor signaling
- Development Role of HDAC and calcium/calmodulin-dependent kinase (CaMK) in control of skeletal myogenesis
2 R&D Systems pathways for YWHAB Gene
2 Tocris pathways for YWHAB Gene
Interacting Proteins for YWHAB Gene
Selected Interacting proteins:
P31946-1433B_HUMAN
ENSP00000300161
for YWHAB Gene via
MINT
STRING
UniProtKB
I2D
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0000186 | activation of MAPKK activity | TAS | -- |
| GO:0006367 | transcription initiation from RNA polymerase II promoter | TAS | -- |
| GO:0006915 | apoptotic process | TAS | -- |
| GO:0007173 | epidermal growth factor receptor signaling pathway | TAS | -- |
| GO:0007411 | axon guidance | TAS | -- |
Drugs & Compounds for YWHAB Gene
| Name | Status | Disease Links | Group | Role | Mechanism of Action | Clinical Trials |
|---|---|---|---|---|---|---|
| Zolpidem | Approved | Pharma | Full agonist, Allosteric regulator | 98 |
| Name | Synonyms | Role | CAS Number | PubChem IDs | PubMed IDs | |
|---|---|---|---|---|---|---|
| Sepiapterin |
|
17094-01-8 |
|
|||
| Difopein |
|
396834-58-5 |
|
|
||
| R18 |
|
211364-78-2 |
|
|
(2) Tocris Compounds for YWHAB Gene
Transcripts for YWHAB Gene
mRNA/cDNA for YWHAB Gene
- (2) REFSEQ mRNAs :
- (10) Additional mRNA sequences :
- (1367) Selected AceView cDNA sequences:
- (8) Ensembl transcripts including schematic representations, and UCSC links where relevant :
Unigene Clusters for YWHAB Gene
CRISPR Products
-
OriGene CRISPR knockouts for YWHAB
-
Santa Cruz Biotechnology (SCBT) CRISPR for YWHAB
- GenScript: Design CRISPR guide RNA sequences for YWHAB
miRNA Products
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Clone Products
- OriGene clones in human for YWHAB
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- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
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- Addgene plasmids for YWHAB
Flow Cytometry Products
| ExUns: | 1a | · | 1b | ^ | 2 | ^ | 3a | · | 3b | ^ | 4a | · | 4b | · | 4c | · | 4d | ^ | 5a | · | 5b | · | 5c | ^ | 6a | · | 6b | ^ | 7a | · | 7b | ^ | 8 | ^ | 9a | · | 9b | · | 9c |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| SP1: | - | - | - | - | - | - | |||||||||||||||||||||||||||||||||
| SP2: | - | - | - | - | - | - | - | ||||||||||||||||||||||||||||||||
| SP3: | |||||||||||||||||||||||||||||||||||||||
| SP4: | - | ||||||||||||||||||||||||||||||||||||||
| SP5: | - | ||||||||||||||||||||||||||||||||||||||
| SP6: | |||||||||||||||||||||||||||||||||||||||
| SP7: | - | - | - | - | - | - | |||||||||||||||||||||||||||||||||
| SP8: | - | - | - | - | - | - | |||||||||||||||||||||||||||||||||
| SP9: | - | ||||||||||||||||||||||||||||||||||||||
| SP10: | - | - | - |
Expression for YWHAB Gene
Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for YWHAB Gene
SOURCE GeneReport for Unigene cluster for YWHAB Gene Hs.643544
- Elite partner
Primer Products
-
OriGene qPCR primer pairs for YWHAB
-
OriGene qPCR primer pairs and template standards for YWHAB
No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for YWHAB Gene
Orthologs for YWHAB Gene
This gene was present in the common ancestor of animals.
| Organism | Taxonomy | Gene | Similarity | Type | Details |
|---|---|---|---|---|---|
| cow (Bos Taurus) |
Mammalia | YWHAB 35 |
|
||
| YWHAB 36 |
|
OneToOne | |||
| dog (Canis familiaris) |
Mammalia | YWHAB 35 |
|
||
| YWHAB 36 |
|
OneToOne | |||
| mouse (Mus musculus) |
Mammalia | Ywhab 35 |
|
||
| Ywhab 16 |
|
||||
| Ywhab 36 |
|
OneToOne | |||
| chimpanzee (Pan troglodytes) |
Mammalia | YWHAB 35 |
|
||
| YWHAB 36 |
|
OneToOne | |||
| rat (Rattus norvegicus) |
Mammalia | Ywhab 35 |
|
||
| oppossum (Monodelphis domestica) |
Mammalia | YWHAB 36 |
|
OneToOne | |
| platypus (Ornithorhynchus anatinus) |
Mammalia | YWHAB 36 |
|
OneToOne | |
| chicken (Gallus gallus) |
Aves | YWHAB 35 |
|
||
| YWHAB 36 |
|
OneToOne | |||
| lizard (Anolis carolinensis) |
Reptilia | YWHAB 36 |
|
OneToOne | |
| tropical clawed frog (Silurana tropicalis) |
Amphibia | ywhab 35 |
|
||
| zebrafish (Danio rerio) |
Actinopterygii | -- 35 |
|
||
| ywhaba 35 |
|
||||
| ywhaba 36 |
|
OneToMany | |||
| ywhabb 36 |
|
OneToMany | |||
| fruit fly (Drosophila melanogaster) |
Insecta | 14-3-3zgr 37 |
|
|
|
| 14-3-3zeta 36 |
|
OneToMany | |||
| worm (Caenorhabditis elegans) |
Secernentea | ftt-2 36 |
|
ManyToMany | |
| par-5 36 |
|
ManyToMany | |||
| sea squirt (Ciona intestinalis) |
Ascidiacea | Cin.4900 35 |
|
- Species with no ortholog for YWHAB:
-
- A. gosspyii yeast (Ashbya gossypii)
- Actinobacteria (Mycobacterium tuberculosis)
- African clawed frog (Xenopus laevis)
- African malaria mosquito (Anopheles gambiae)
- Alicante grape (Vitis vinifera)
- alpha proteobacteria (Wolbachia pipientis)
- amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- baker's yeast (Saccharomyces cerevisiae)
- barley (Hordeum vulgare)
- beta proteobacteria (Neisseria meningitidis)
- bread mold (Neurospora crassa)
- Chromalveolata (Phytophthora infestans)
- common water flea (Daphnia pulex)
- corn (Zea mays)
- E. coli (Escherichia coli)
- filamentous fungi (Aspergillus nidulans)
- Firmicute bacteria (Streptococcus pneumoniae)
- fission yeast (Schizosaccharomyces pombe)
- green algae (Chlamydomonas reinhardtii)
- honey bee (Apis mellifera)
- K. lactis yeast (Kluyveromyces lactis)
- loblloly pine (Pinus taeda)
- malaria parasite (Plasmodium falciparum)
- medicago trunc (Medicago Truncatula)
- moss (Physcomitrella patens)
- orangutan (Pongo pygmaeus)
- pig (Sus scrofa)
- rainbow trout (Oncorhynchus mykiss)
- rice (Oryza sativa)
- rice blast fungus (Magnaporthe grisea)
- schistosome parasite (Schistosoma mansoni)
- sea anemone (Nematostella vectensis)
- sea urchin (Strongylocentrotus purpuratus)
- sorghum (Sorghum bicolor)
- soybean (Glycine max)
- stem rust fungus (Puccinia graminis)
- sugarcane (Saccharum officinarum)
- thale cress (Arabidopsis thaliana)
- tomato (Lycopersicon esculentum)
- toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
- wheat (Triticum aestivum)
Paralogs for YWHAB Gene
(9) SIMAP similar genes for YWHAB Gene using alignment to 4 proteins:
Pseudogenes.org Pseudogenes for YWHAB Gene
Variants for YWHAB Gene
| SNP ID | Clin | Chr 20 pos | Sequence Context | AA Info | Type |
|---|---|---|---|---|---|
| VAR_064762 | - | ||||
| rs4931 | -- | 44,901,593(+) | GAGCG(A/C/G/T)TATGA | reference, synonymous-codon | |
| rs6876 | -- | 44,906,460(+) | TGATC(C/T)GTTCA | utr-variant-3-prime | |
| rs8356 | -- | 44,907,814(+) | CAACA(C/T)GGTGT | utr-variant-3-prime | |
| rs8787 | -- | 44,907,618(+) | CTCTT(C/T)TAAGT | utr-variant-3-prime |
Residual Variation Intolerance Score:
35.3% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score:
0.64;
13.61% of all genes are more intolerant (likely to be disease-causing)
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Relevant External Links for YWHAB Gene
Disorders for YWHAB Gene
| Disorder | Aliases | PubMed IDs |
|---|---|---|
| creutzfeldt-jakob disease |
|
|
| gerstmann-straussler disease |
|
|
Search YWHAB in MalaCards
View complete list of genes associated with diseases
Relevant External Links for YWHAB
No data available for UniProtKB/Swiss-Prot and Genatlas for YWHAB Gene
Publications for YWHAB Gene
- Crystal structure of human myosin 1c - the motor in GLUT4 exocytosis: implications for Ca(2+)-regulation and 14-3-3 binding. (PMID: 24636949) Stefan Munnich M.H. … Manstein D.J. (J. Mol. Biol. 2014) 3 4 67
- Assignment of the human genes encoding 14,3-3 Eta (YWHAH) to 22q12, 14-3-3 zeta (YWHAZ) to 2p25.1-p25.2, and 14-3-3 beta (YWHAB) to 20q13.1 by in situ hybridization. (PMID: 8617504) Tommerup N. … Leffers H. (Genomics 1996) 2 3
- 14-3-3 alpha and delta are the phosphorylated forms of raf-activating 14-3-3 beta and zeta. In vivo stoichiometric phosphorylation in brain at a Ser-Pro-Glu-Lys MOTIF. (PMID: 7890696) Aitken A. … Patel Y. (J. Biol. Chem. 1995) 2 3
- Proximity biotinylation and affinity purification are complementary approaches for the interactome mapping of chromatin-associated protein complexes. (PMID: 25281560) Lambert J.P. … Gingras A.C. (J Proteomics 2015) 3
- In silico prediction of physical protein interactions and characterization of interactome orphans. (PMID: 25402006) Kotlyar M. … Jurisica I. (Nat. Methods 2015) 3
Products for YWHAB Gene
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- antibodies-online Antibodies for YWHAB: See all 130
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- antibodies-online Proteins for YWHAB: See all 7
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- ViGene Biosciences adenoviral particle packaged cDNA for YWHAB gene
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- Santa Cruz Biotechnology (SCBT) Antibodies for YWHAB
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- Santa Cruz Biotechnology (SCBT) CRISPR for YWHAB
Sources for YWHAB Gene
- (1) GeneCards
- (2) HGNC
- (3) EntrezGene
- (4) Swiss-Prot
- (5) Ensembl
- (6) OMIM
- (7) GeneLoc
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