Aliases for YWHAB Gene
Aliases for YWHAB Gene
- Tyrosine 3-Monooxygenase/Tryptophan 5-Monooxygenase Activation Protein Beta 2 3 5
- Tyrosine 3-Monooxygenase/Tryptophan 5-Monooxygenase Activation Protein, Alpha Polypeptide 2 3
- Tyrosine 3-Monooxygenase/Tryptophan 5-Monooxygenase Activation Protein, Beta Polypeptide 2 3
- 14-3-3 Alpha 2 3
- Protein 1054 3 4
- KCIP-1 3 4
- Protein Kinase C Inhibitor Protein-1 3
- Protein Kinase C Inhibitor Protein 1 4
- Brain Protein 14-3-3, Beta Isoform 3
External Ids for YWHAB Gene
- HGNC: 12849
- Entrez Gene: 7529
- Ensembl: ENSG00000166913
- OMIM: 601289
- UniProtKB: P31946
Previous HGNC Symbols for YWHAB Gene
- YWHAA
Previous GeneCards Identifiers for YWHAB Gene
- GC20P043242
- GC20P043202
- GC20P044152
- GC20P044199
- GC20P042947
- GC20P043515
- GC20P040256
Summaries for YWHAB Gene
-
This gene encodes a protein belonging to the 14-3-3 family of proteins, members of which mediate signal transduction by binding to phosphoserine-containing proteins. This highly conserved protein family is found in both plants and mammals. The encoded protein has been shown to interact with RAF1 and CDC25 phosphatases, suggesting that it may play a role in linking mitogenic signaling and the cell cycle machinery. Two transcript variants, which encode the same protein, have been identified for this gene. [provided by RefSeq, Jul 2008]
GeneCards Summary for YWHAB Gene
YWHAB (Tyrosine 3-Monooxygenase/Tryptophan 5-Monooxygenase Activation Protein Beta) is a Protein Coding gene. Diseases associated with YWHAB include Eosinophilic Meningitis and Gerstmann-Straussler Disease. Among its related pathways are RET signaling and NFAT and Cardiac Hypertrophy. Gene Ontology (GO) annotations related to this gene include enzyme binding and protein complex binding. An important paralog of this gene is YWHAZ.
UniProtKB/Swiss-Prot for YWHAB Gene
-
Adapter protein implicated in the regulation of a large spectrum of both general and specialized signaling pathways. Binds to a large number of partners, usually by recognition of a phosphoserine or phosphothreonine motif. Binding generally results in the modulation of the activity of the binding partner. Negative regulator of osteogenesis. Blocks the nuclear translocation of the phosphorylated form (by AKT1) of SRPK2 and antagonizes its stimulatory effect on cyclin D1 expression resulting in blockage of neuronal apoptosis elicited by SRPK2. Negative regulator of signaling cascades that mediate activation of MAP kinases via AKAP13.
-
14.3.3 proteins are a group of highly conserved proteins that are involved in many vital cellular processes such as metabolism, protein trafficking, signal transduction, apoptosis and cell cycle regulation. 14.3.3 proteins are phospho-serine/-threonine binding proteins.
No data available for CIViC summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for YWHAB Gene
Genomics for YWHAB Gene
GeneHancer (GH) Regulatory Elements for YWHAB Gene
Promoters and enhancers for YWHAB Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association
Download GeneHancer data dump
GeneHancers around YWHAB on UCSC Golden Path with GeneCards custom track
Regulatory Element Products
Genomic Locations for YWHAB Gene
Genomic Locations for YWHAB Gene
- chr20:44,885,599-44,908,532
- (GRCh38/hg38)
- Size:
- 22,934 bases
- Orientation:
- Plus strand
- chr20:43,514,317-43,537,173
- (GRCh37/hg19)
Genomic View for YWHAB Gene
Genes around YWHAB on UCSC Golden Path with GeneCards custom track
- Cytogenetic band:
-
- 20q13.12 by Ensembl
- 20q13.12 by Entrez Gene
- 20q13.12 by HGNC
YWHAB Gene in genomic location: bands according to
Ensembl, locations according to GeneLoc
(and/or Entrez Gene and/or Ensembl if different)
Genomic Neighborhood
• Exon Structure
• Gene Density
RefSeq DNA sequence for YWHAB Gene
Proteins for YWHAB Gene
-
Protein details for YWHAB Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- P31946-1433B_HUMAN
- Recommended name:
- 14-3-3 protein beta/alpha
- Protein Accession:
- P31946
- A8K9K2
- E1P616
Protein attributes for YWHAB Gene
- Size:
- 246 amino acids
- Molecular mass:
- 28082 Da
- Quaternary structure:
-
- Homodimer (PubMed:17717073). Interacts with SAMSN1 and PRKCE (By similarity). Interacts with AKAP13 (PubMed:21224381). Interacts with SSH1 and TORC2/CRTC2 (PubMed:15454081, PubMed:15159416). Interacts with ABL1; the interaction results in cytoplasmic location of ABL1 and inhibition of cABL-mediated apoptosis (PubMed:15696159). Interacts with ROR2 (dimer); the interaction results in phosphorylation of YWHAB on tyrosine residues (PubMed:17717073). Interacts with GAB2 (PubMed:19172738). Interacts with YAP1 (phosphorylated form) (PubMed:17974916). Interacts with the phosphorylated (by AKT1) form of SRPK2 (PubMed:19592491). Interacts with PKA-phosphorylated AANAT (PubMed:11427721). Interacts with MYO1C (PubMed:24636949). Interacts with SIRT2 (PubMed:18249187). Interacts with the Thr-369 phosphorylated form of DAPK2 (PubMed:26047703). Interacts with PI4KB, TBC1D22A and TBC1D22B (PubMed:23572552). Interacts with the Ser-1134 and Ser-1161 phosphorylated form of SOS1 (PubMed:22827337). Interacts (via phosphorylated form) with YWHAB; this interaction occurs in a protein kinase AKT1-dependent manner (PubMed:15538381). Interacts with SLITRK1 (PubMed:19640509). Interacts with SYNPO2 (phosphorylated form); YWHAB competes with ACTN2 for interaction with SYNPO2 (By similarity). Interacts with RIPOR2 (via phosphorylated form) isoform 2; this interaction occurs in a chemokine-dependent manner and does not compete for binding of RIPOR2 with RHOA nor blocks inhibition of RIPOR2-mediated RHOA activity (PubMed:25588844).
- (Microbial infection) Interacts with herpes simplex virus 1 protein UL46.
Three dimensional structures from OCA and Proteopedia for YWHAB Gene
Protein Expression for YWHAB Gene
Post-translational modifications for YWHAB Gene
- The alpha, brain-specific form differs from the beta form in being phosphorylated. Phosphorylated on Ser-60 by protein kinase C delta type catalytic subunit in a sphingosine-dependent fashion.
- Ubiquitination at isoforms=211, posLast=117117, and posLast=140140
Other Protein References for YWHAB Gene
- ENSEMBL proteins:
- REFSEQ proteins:
Antibody Products
- R&D Systems Antibodies for YWHAB (14-3-3 beta)
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-
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- antibodies-online: Search results for 205 available HCLS1 Antibodies ranked by validation data
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- 2 IHC Antibodies (anti-human)
- 68 WB Antibodies (anti-mouse)
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- 2 IHC (p) Antibodies (anti-mouse)
- 1 IHC Antibody (anti-mouse)
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- 68 WB Antibodies (anti-mouse)
- 12 IF (p) Antibodies (anti-mouse)
- 2 IHC (p) Antibodies (anti-mouse)
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- GeneTex YWHAB antibody for YWHAB
-
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Protein Products
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-
ProSci Proteins for YWHAB
-
Abcam proteins for YWHAB
Assay Products
- antibodies-online: Search results for 16 available HCLS1 Elisa Kits ranked by validation data
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No data available for DME Specific Peptides for YWHAB Gene
Domains & Families for YWHAB Gene
Gene Families for YWHAB Gene
- HGNC:
- Human Protein Atlas (HPA):
-
- Cancer-related genes
- Plasma proteins
- Predicted intracellular proteins
Protein Domains for YWHAB Gene
- InterPro:
- Blocks:
- ProtoNet:
Suggested Antigen Peptide Sequences for YWHAB Gene
- GenScript: Design optimal peptide antigens:
Graphical View of Domain Structure for InterPro Entry
P31946- Family:
-
- Belongs to the 14-3-3 family.
Function for YWHAB Gene
Molecular function for YWHAB Gene
- GENATLAS Biochemistry:
- tyrosine 3-monooxygenase/trytophan 5 monooxygenase activation protein,14-3-3 beta protein,including the phosphorylated form YWHAA (alpha),multifunctional regulator involved in cell-cyle control (checkpoint) and signal transduction,inhibitor of apoptosis through inhibiting the activation of p38 MAP kinase
- UniProtKB/Swiss-Prot Function:
- Adapter protein implicated in the regulation of a large spectrum of both general and specialized signaling pathways. Binds to a large number of partners, usually by recognition of a phosphoserine or phosphothreonine motif. Binding generally results in the modulation of the activity of the binding partner. Negative regulator of osteogenesis. Blocks the nuclear translocation of the phosphorylated form (by AKT1) of SRPK2 and antagonizes its stimulatory effect on cyclin D1 expression resulting in blockage of neuronal apoptosis elicited by SRPK2. Negative regulator of signaling cascades that mediate activation of MAP kinases via AKAP13.
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0003714 | transcription corepressor activity | IEA | -- |
| GO:0005515 | protein binding | IPI | 7644510 |
| GO:0008022 | protein C-terminus binding | IEA | -- |
| GO:0019899 | enzyme binding | IPI | 17255105 |
| GO:0019904 | protein domain specific binding | IEA,IPI | 11984006 |
Phenotypes for YWHAB Gene
- GenomeRNAi human phenotypes for YWHAB:
Animal Model Products
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CRISPR Products
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miRNA for YWHAB Gene
- miRTarBase miRNAs that target YWHAB
-
- hsa-mir-1301-3p (MIRT035990)
- hsa-mir-877-3p (MIRT037014)
- hsa-mir-378a-5p (MIRT044012)
- hsa-mir-221-3p (MIRT046917)
- hsa-mir-218-5p (MIRT439267)
- hsa-mir-627-3p (MIRT505094)
- hsa-mir-6758-3p (MIRT505095)
- hsa-mir-5094 (MIRT505096)
- hsa-mir-513c-3p (MIRT505097)
- hsa-mir-513a-3p (MIRT505098)
- hsa-mir-3606-3p (MIRT505099)
- hsa-mir-551b-5p (MIRT505100)
- hsa-mir-148b-3p (MIRT505101)
- hsa-mir-148a-3p (MIRT505102)
- hsa-mir-152-3p (MIRT505103)
- hsa-mir-744-3p (MIRT529358)
- hsa-mir-620 (MIRT529359)
- hsa-mir-1270 (MIRT529360)
- hsa-mir-4423-5p (MIRT529361)
- hsa-mir-6501-5p (MIRT529362)
- hsa-mir-143-5p (MIRT529363)
- hsa-mir-4430 (MIRT529364)
- hsa-mir-3652 (MIRT529365)
- hsa-mir-122-5p (MIRT529366)
- hsa-mir-504-3p (MIRT529367)
- hsa-mir-4683 (MIRT529368)
- hsa-mir-3135b (MIRT529369)
- hsa-mir-6088 (MIRT529370)
- hsa-mir-4770 (MIRT529371)
- hsa-mir-143-3p (MIRT529372)
- hsa-mir-4781-3p (MIRT529373)
- hsa-mir-4457 (MIRT641784)
- hsa-mir-7850-5p (MIRT706790)
- hsa-mir-4531 (MIRT706791)
- hsa-mir-1255a (MIRT761654)
- hsa-mir-1255b-5p (MIRT761663)
- hsa-mir-1273h-5p (MIRT762101)
- hsa-mir-1909-5p (MIRT763253)
- hsa-mir-30b-3p (MIRT764639)
- hsa-mir-30c-1-3p (MIRT764686)
- hsa-mir-30c-2-3p (MIRT764731)
- hsa-mir-3614-5p (MIRT766075)
- hsa-mir-3661 (MIRT766457)
- hsa-mir-3663-3p (MIRT766462)
- hsa-mir-3689a-3p (MIRT766867)
- hsa-mir-3689b-3p (MIRT766955)
- hsa-mir-3689c (MIRT767043)
- hsa-mir-4269 (MIRT768242)
- hsa-mir-4299 (MIRT768482)
- hsa-mir-4325 (MIRT768651)
- hsa-mir-542-3p (MIRT773980)
- hsa-mir-5582-5p (MIRT774723)
- hsa-mir-619-3p (MIRT776045)
- hsa-mir-631 (MIRT776135)
- hsa-mir-6715b-5p (MIRT777696)
- hsa-mir-6731-5p (MIRT777987)
- hsa-mir-6744-5p (MIRT778188)
- hsa-mir-6779-5p (MIRT778945)
- hsa-mir-6780a-5p (MIRT779035)
- hsa-mir-6788-5p (MIRT779263)
- hsa-mir-6878-5p (MIRT780780)
- hsa-mir-769-5p (MIRT781971)
- hsa-mir-8085 (MIRT782430)
- hsa-mir-887-5p (MIRT782581)
- hsa-mir-130b-5p (MIRT783740)
- hsa-mir-4753-3p (MIRT786616)
- hsa-mir-6809-3p (MIRT788883)
miRNA Products
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Inhibitory RNA Products
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Recommended
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- pLenti-U6-sgRNA-PGK-Neo
- pDONR223
- pLenti-C-mGFP
- pLenti-C-Myc-DDK
- pCMV6-Entry
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- pPB-C-His
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- pLenti-U6-sgRNA-PGK-Neo
- pDONR223
- pLenti-C-mGFP
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-
ViGene Biosciences ready-to-package AAV shRNAs for YWHAB gene
Clone Products
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-
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- Mammalian expression: PiggyBac
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- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
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Recommended
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Recommended
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- pPB-N-His
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- pLenti-U6-sgRNA-PGK-Neo
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Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more
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No data available for Enzyme Numbers (IUBMB) , Phenotypes From GWAS Catalog , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for YWHAB Gene
Localization for YWHAB Gene
Subcellular locations from UniProtKB/Swiss-Prot for YWHAB Gene
- Cytoplasm. Melanosome. Note=Identified by mass spectrometry in melanosome fractions from stage I to stage IV.
| Compartment | Confidence |
|---|---|
| extracellular | 5 |
| cytosol | 5 |
| nucleus | 4 |
| mitochondrion | 3 |
| plasma membrane | 1 |
| cytoskeleton | 1 |
| endoplasmic reticulum | 1 |
| golgi apparatus | 1 |
- Cytosol (3)
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0005634 | nucleus | IEA | -- |
| GO:0005737 | cytoplasm | IDA,IEA | 10869435 |
| GO:0005739 | mitochondrion | IEA | -- |
| GO:0005829 | cytosol | TAS | -- |
| GO:0005925 | focal adhesion | HDA,IDA | 21423176 |
Pathways & Interactions for YWHAB Gene
| SuperPathway | Contained pathways | ||
|---|---|---|---|
| 1 | RET signaling |
.92
|
.92
|
| 2 | CDK-mediated phosphorylation and removal of Cdc6 |
.31
|
|
| 3 | Signaling by moderate kinase activity BRAF mutants | ||
| 4 | Activation of cAMP-Dependent PKA |
.77
|
.56
|
| 5 | mTOR signalling |
.70
|
.51
|
Pathways by source for YWHAB Gene
6 Sino Biological pathways for YWHAB Gene
2 GeneTex pathways for YWHAB Gene
4 Cell Signaling Technology pathways for YWHAB Gene
17 BioSystems pathways for YWHAB Gene
87 Reactome pathways for YWHAB Gene
7 KEGG pathways for YWHAB Gene
7 GeneGo (Thomson Reuters) pathways for YWHAB Gene
- Apoptosis and survival BAD phosphorylation
- Cell cycle Role of 14-3-3 proteins in cell cycle regulation
- Cytoskeleton remodeling Role of PKA in cytoskeleton reorganisation
- Development IGF-1 receptor signaling
- Development Role of HDAC and calcium/calmodulin-dependent kinase (CaMK) in control of skeletal myogenesis
1 R&D Systems pathway for YWHAB Gene
2 Tocris pathways for YWHAB Gene
Interacting Proteins for YWHAB Gene
Selected Interacting proteins:
P31946-1433B_HUMAN
ENSP00000300161
for YWHAB Gene via
MINT
STRING
UniProtKB
IID
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0000165 | MAPK cascade | TAS | -- |
| GO:0006605 | protein targeting | IEA | -- |
| GO:0016032 | viral process | IEA | -- |
| GO:0035308 | negative regulation of protein dephosphorylation | IDA | 17255105 |
| GO:0035329 | hippo signaling | TAS | -- |
Drugs & Compounds for YWHAB Gene
| Name | Status | Disease Links | Group | Role | Mechanism of Action | Clinical Trials |
|---|---|---|---|---|---|---|
| Copper | Approved, Investigational | Pharma | Target | 202 | ||
| Zolpidem | Approved | Pharma | Full agonist, Allosteric regulator | 110 | ||
| Phenethyl isothiocyanate | Investigational | Pharma | Target | 12 | ||
| R18 | Pharma | 14.3.3 proteins Antagonist, Inhibitor of 14.3.3 proteins | 0 |
| Name | Synonyms | Role | CAS Number | PubChem IDs | PubMed IDs | |
|---|---|---|---|---|---|---|
| Sepiapterin |
|
17094-01-8 |
|
|||
| Difopein |
|
396834-58-5 |
|
|
(2) Tocris Compounds for YWHAB Gene
(1) ApexBio Compounds for YWHAB Gene
| Compound | Action | Cas Number |
|---|---|---|
| R18 | 14.3.3 proteins Antagonist | 211364-78-2 |
Transcripts for YWHAB Gene
mRNA/cDNA for YWHAB Gene
- (4) REFSEQ mRNAs :
- (10) Additional mRNA sequences :
- (1367) Selected AceView cDNA sequences:
- (8) Ensembl transcripts including schematic representations, and UCSC links where relevant :
Unigene Clusters for YWHAB Gene
CRISPR Products
-
OriGene CRISPR knockouts for YWHAB
- genomics-online: gRNA clones - Search results for 108 available YWHAB gene related products
- Overview of 108 available YWHAB gene related products
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Recommended
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- pGFP-V-RS
- pPB-N-His
- pPB-C-His
- pLenti-U6-sgRNA-SFFV-Cas9-2A-Puro
- pLenti-U6-sgRNA-PGK-Neo
- pDONR223
- pLenti-C-mGFP
- pLenti-C-Myc-DDK
- pCMV6-Entry
- pCMV6-AC
- pRFP-C-RS
- pGFP-V-RS
- pPB-N-His
- pPB-C-His
- pLenti-U6-sgRNA-SFFV-Cas9-2A-Puro
- pLenti-U6-sgRNA-PGK-Neo
- pDONR223
- pLenti-C-mGFP
- pLenti-C-Myc-DDK
- pCMV6-Entry
- pCMV6-AC
- Applied Biological Materials CRISPR for YWHAB
-
Vectors and viruses for KO, Activation, Repression, and more
-
Santa Cruz Biotechnology (SCBT) CRISPR for YWHAB
- GenScript: Design CRISPR guide RNA sequences for YWHAB
miRNA Products
- Search ViGene Biosciences for YWHAB
Inhibitory RNA Products
- Origene RNAi, sirna, and shrna products in human, mouse, rat for YWHAB
- Browse OriGene Inhibitory RNA Products For YWHAB
- genomics-online: shRNA clones - Search results for 108 available YWHAB gene related products
- Overview of 108 available YWHAB gene related products
-
Recommended
- pRFP-C-RS
- pGFP-V-RS
- pPB-N-His
- pPB-C-His
- pLenti-U6-sgRNA-SFFV-Cas9-2A-Puro
- pLenti-U6-sgRNA-PGK-Neo
- pDONR223
- pLenti-C-mGFP
- pLenti-C-Myc-DDK
- pCMV6-Entry
- pCMV6-AC
- pRFP-C-RS
- pGFP-V-RS
- pPB-N-His
- pPB-C-His
- pLenti-U6-sgRNA-SFFV-Cas9-2A-Puro
- pLenti-U6-sgRNA-PGK-Neo
- pDONR223
- pLenti-C-mGFP
- pLenti-C-Myc-DDK
- pCMV6-Entry
- pCMV6-AC
-
ViGene Biosciences ready-to-package AAV shRNAs for YWHAB gene
Clone Products
- Sino Biological Human cDNA Clone for YWHAB
- Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat
- VectorBuilder custom plasmid, inducible vectors for YWHAB
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for YWHAB
-
VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
- Addgene plasmids for YWHAB
- genomics-online: cdna clones - Search results for 108 available HCLS1 gene related products
- Overview of 108 available HCLS1 gene related products
-
Recommended
- pLenti-U6-sgRNA-SFFV-Cas9-2A-Puro
- pLenti-U6-sgRNA-PGK-Neo
- pDONR223
- pLenti-C-mGFP
- pLenti-C-Myc-DDK
- pCMV6-Entry
- pCMV6-AC
- pRFP-C-RS
- pGFP-V-RS
- pPB-N-His
- pPB-C-His
- pLenti-U6-sgRNA-SFFV-Cas9-2A-Puro
- pLenti-U6-sgRNA-PGK-Neo
- pDONR223
- pLenti-C-mGFP
- pLenti-C-Myc-DDK
- pCMV6-Entry
- pCMV6-AC
- pRFP-C-RS
- pGFP-V-RS
- pPB-N-His
- pPB-C-His
- orf clones - Search results for 108 available YWHAB gene related products
- Overview of 108 available YWHAB gene related products
-
Recommended
- pRFP-C-RS
- pGFP-V-RS
- pPB-N-His
- pPB-C-His
- pLenti-U6-sgRNA-SFFV-Cas9-2A-Puro
- pLenti-U6-sgRNA-PGK-Neo
- pDONR223
- pLenti-C-mGFP
- pLenti-C-Myc-DDK
- pCMV6-Entry
- pCMV6-AC
- pRFP-C-RS
- pGFP-V-RS
- pPB-N-His
- pPB-C-His
- pLenti-U6-sgRNA-SFFV-Cas9-2A-Puro
- pLenti-U6-sgRNA-PGK-Neo
- pDONR223
- pLenti-C-mGFP
- pLenti-C-Myc-DDK
- pCMV6-Entry
- pCMV6-AC
- Applied Biological Materials Clones for YWHAB
-
Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more
| ExUns: | 1a | · | 1b | ^ | 2 | ^ | 3a | · | 3b | ^ | 4a | · | 4b | · | 4c | · | 4d | ^ | 5a | · | 5b | · | 5c | ^ | 6a | · | 6b | ^ | 7a | · | 7b | ^ | 8 | ^ | 9a | · | 9b | · | 9c |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| SP1: | - | - | - | - | - | - | |||||||||||||||||||||||||||||||||
| SP2: | - | - | - | - | - | - | - | ||||||||||||||||||||||||||||||||
| SP3: | |||||||||||||||||||||||||||||||||||||||
| SP4: | - | ||||||||||||||||||||||||||||||||||||||
| SP5: | - | ||||||||||||||||||||||||||||||||||||||
| SP6: | |||||||||||||||||||||||||||||||||||||||
| SP7: | - | - | - | - | - | - | |||||||||||||||||||||||||||||||||
| SP8: | - | - | - | - | - | - | |||||||||||||||||||||||||||||||||
| SP9: | - | ||||||||||||||||||||||||||||||||||||||
| SP10: | - | - | - |
Expression for YWHAB Gene
Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for YWHAB Gene
- Elite partner
NURSA nuclear receptor signaling pathways regulating expression of YWHAB Gene:
YWHABSOURCE GeneReport for Unigene cluster for YWHAB Gene:
Hs.643544Evidence on tissue expression from TISSUES for YWHAB Gene
- Skin(4.9)
- Nervous system(4.9)
- Liver(4.7)
- Blood(4.6)
- Intestine(4.2)
- Lung(4.1)
- Pancreas(3.9)
- Kidney(3.5)
- Eye(3.1)
- Heart(2.5)
- Spleen(2.2)
- Lymph node(2.1)
- Muscle(2.1)
- Stomach(2)
Primer Products
-
OriGene qPCR primer pairs for YWHAB
-
OriGene qPCR primer pairs and template standards for YWHAB
- genomics-online: primer clones - Search results for 108 available YWHAB gene related products
- Overview of 108 available YWHAB gene related products
-
Recommended
- pRFP-C-RS
- pGFP-V-RS
- pPB-N-His
- pPB-C-His
- pLenti-U6-sgRNA-SFFV-Cas9-2A-Puro
- pLenti-U6-sgRNA-PGK-Neo
- pDONR223
- pLenti-C-mGFP
- pLenti-C-Myc-DDK
- pCMV6-Entry
- pCMV6-AC
- pRFP-C-RS
- pGFP-V-RS
- pPB-N-His
- pPB-C-His
- pLenti-U6-sgRNA-SFFV-Cas9-2A-Puro
- pLenti-U6-sgRNA-PGK-Neo
- pDONR223
- pLenti-C-mGFP
- pLenti-C-Myc-DDK
- pCMV6-Entry
- pCMV6-AC
No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for YWHAB Gene
Orthologs for YWHAB Gene
This gene was present in the common ancestor of animals.
| Organism | Taxonomy | Gene | Similarity | Type | Details |
|---|---|---|---|---|---|
| chimpanzee (Pan troglodytes) |
Mammalia | YWHAB 33 34 |
|
||
| dog (Canis familiaris) |
Mammalia | YWHAB 33 34 |
|
||
| cow (Bos Taurus) |
Mammalia | YWHAB 33 34 |
|
||
| oppossum (Monodelphis domestica) |
Mammalia | YWHAB 34 |
|
OneToOne | |
| rat (Rattus norvegicus) |
Mammalia | Ywhab 33 |
|
||
| mouse (Mus musculus) |
Mammalia | Ywhab 33 16 34 |
|
||
| platypus (Ornithorhynchus anatinus) |
Mammalia | YWHAB 34 |
|
OneToOne | |
| chicken (Gallus gallus) |
Aves | YWHAB 33 34 |
|
||
| lizard (Anolis carolinensis) |
Reptilia | YWHAB 34 |
|
OneToOne | |
| tropical clawed frog (Silurana tropicalis) |
Amphibia | ywhab 33 |
|
||
| zebrafish (Danio rerio) |
Actinopterygii | ywhabb 34 |
|
OneToMany | |
| ywhaba 33 34 |
|
||||
| -- 33 |
|
||||
| fruit fly (Drosophila melanogaster) |
Insecta | 14-3-3zgr 35 |
|
|
|
| 14-3-3zeta 34 |
|
OneToMany | |||
| worm (Caenorhabditis elegans) |
Secernentea | ftt-2 34 |
|
ManyToMany | |
| par-5 34 |
|
ManyToMany | |||
| sea squirt (Ciona intestinalis) |
Ascidiacea | Cin.4900 33 |
|
- Species where no ortholog for YWHAB was found in the sources mined by GeneCards:
-
- A. gosspyii yeast (Ashbya gossypii)
- Actinobacteria (Mycobacterium tuberculosis)
- African clawed frog (Xenopus laevis)
- African malaria mosquito (Anopheles gambiae)
- Alicante grape (Vitis vinifera)
- alpha proteobacteria (Wolbachia pipientis)
- amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- baker's yeast (Saccharomyces cerevisiae)
- barley (Hordeum vulgare)
- beta proteobacteria (Neisseria meningitidis)
- bread mold (Neurospora crassa)
- Chromalveolata (Phytophthora infestans)
- common water flea (Daphnia pulex)
- corn (Zea mays)
- E. coli (Escherichia coli)
- filamentous fungi (Aspergillus nidulans)
- Firmicute bacteria (Streptococcus pneumoniae)
- fission yeast (Schizosaccharomyces pombe)
- green algae (Chlamydomonas reinhardtii)
- honey bee (Apis mellifera)
- K. lactis yeast (Kluyveromyces lactis)
- loblloly pine (Pinus taeda)
- malaria parasite (Plasmodium falciparum)
- medicago trunc (Medicago Truncatula)
- moss (Physcomitrella patens)
- orangutan (Pongo pygmaeus)
- pig (Sus scrofa)
- rainbow trout (Oncorhynchus mykiss)
- rice (Oryza sativa)
- rice blast fungus (Magnaporthe grisea)
- schistosome parasite (Schistosoma mansoni)
- sea anemone (Nematostella vectensis)
- sea urchin (Strongylocentrotus purpuratus)
- sorghum (Sorghum bicolor)
- soybean (Glycine max)
- stem rust fungus (Puccinia graminis)
- sugarcane (Saccharum officinarum)
- thale cress (Arabidopsis thaliana)
- tomato (Lycopersicon esculentum)
- toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
- wheat (Triticum aestivum)
Paralogs for YWHAB Gene
(9) SIMAP similar genes for YWHAB Gene using alignment to 4 proteins:
Pseudogenes.org Pseudogenes for YWHAB Gene
Variants for YWHAB Gene
| SNP ID | Clin | Chr 20 pos | Variation | AA Info | Type |
|---|---|---|---|---|---|
| rs1000078233 | -- | 44,887,523(+) | T/C | intron_variant | |
| rs1000120262 | -- | 44,885,261(+) | G/A | upstream_transcript_variant | |
| rs1000317881 | -- | 44,890,836(+) | G/A | intron_variant | |
| rs1000483521 | -- | 44,902,788(+) | A/G | intron_variant | |
| rs1000575536 | -- | 44,885,018(+) | C/A | upstream_transcript_variant |
| Variant ID | Type | Subtype | PubMed ID |
|---|---|---|---|
| nsv1056102 | CNV | loss | 25217958 |
| nsv1058850 | CNV | gain | 25217958 |
| nsv1062628 | CNV | gain | 25217958 |
| nsv518547 | CNV | gain | 19592680 |
| nsv586077 | CNV | gain | 21841781 |
| nsv954044 | CNV | duplication | 24416366 |
Residual Variation Intolerance Score:
35.3% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score:
0.64;
13.61% of all genes are more intolerant (likely to be disease-causing)
Additional Variant Information for YWHAB Gene
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for YWHAB Gene
Disorders for YWHAB Gene
| Disorder | Aliases | PubMed IDs |
|---|---|---|
| eosinophilic meningitis |
|
|
| gerstmann-straussler disease |
|
|
| ogden syndrome |
|
|
| chronic meningitis |
|
|
| tuberous sclerosis 2 |
|
|
Search YWHAB in MalaCards
View complete list of genes associated with diseases
Additional Disease Information for YWHAB
- Genetic Association Database
- (GAD)
- Human Genome Epidemiology Navigator
- (HuGE)
- ATLAS of Genetics and Cytogenetics in Oncology and Haematology
No data available for UniProtKB/Swiss-Prot and Genatlas for YWHAB Gene
Publications for YWHAB Gene
- Front-signal-dependent accumulation of the RHOA inhibitor FAM65B at leading edges polarizes neutrophils. (PMID: 25588844) Gao K … Wu D (Journal of cell science 2015) 3 4 58
- Crystal structure of human myosin 1c--the motor in GLUT4 exocytosis: implications for Ca2+ regulation and 14-3-3 binding. (PMID: 24636949) Münnich S … Manstein DJ (Journal of molecular biology 2014) 3 4 58
- ACBD3 interaction with TBC1 domain 22 protein is differentially affected by enteroviral and kobuviral 3A protein binding. (PMID: 23572552) Greninger AL … DeRisi JL (mBio 2013) 3 4 58
- A proteomic perspective of inbuilt viral protein regulation: pUL46 tegument protein is targeted for degradation by ICP0 during herpes simplex virus type 1 infection. (PMID: 23938468) Lin AE … Cristea IM (Molecular & cellular proteomics : MCP 2013) 3 4 58
- A-kinase anchoring protein (AKAP)-Lbc anchors a PKN-based signaling complex involved in α1-adrenergic receptor-induced p38 activation. (PMID: 21224381) Cariolato L … Diviani D (The Journal of biological chemistry 2011) 3 4 58
Products for YWHAB Gene
- R&D Systems Antibodies for YWHAB (14-3-3 beta)
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- Cloud-Clone Corp. primary cells service
- Invitrogen Antibodies for YWHAB
- Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat
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- VectorBuilder custom plasmid, inducible vectors for YWHAB
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for YWHAB
- VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
- Addgene plasmids for YWHAB
- antibodies-online: Search results for 205 available HCLS1 Antibodies ranked by validation data
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- 163 WB Antibodies (anti-human)
- 12 IF (p) Antibodies (anti-human)
- 4 FACS Antibodies (anti-human)
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- 12 IF (p) Antibodies (anti-rat)
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- antibodies-online: Search results for 16 available HCLS1 Elisa Kits ranked by validation data
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- 1 Cow (Bovine) ELISA Kit
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- 6 Human ELISA Kits
- 1 Monkey ELISA Kit
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- 1 Pig (Porcine) ELISA Kit
- 1 Rabbit ELISA Kit
- 1 Rat (Rattus) ELISA Kit
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- antibodies-online: Search results for 25 available HCLS1 Proteins ranked by validation data
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- GeneTex YWHAB antibody for YWHAB
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- ViGene Biosciences adenoviral particle packaged cDNA for YWHAB gene
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- Santa Cruz Biotechnology (SCBT) Antibodies for YWHAB
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- genomics-online: cdna clones - Search results for 108 available HCLS1 gene related products
- Overview of 108 available HCLS1 gene related products
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- pCMV6-AC
- pCMV6-Entry
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- pLenti-U6-sgRNA-SFFV-Cas9-2A-Puro
- pPB-C-His
- pPB-N-His
- pGFP-V-RS
- pRFP-C-RS
- pCMV6-AC
- pCMV6-Entry
- pLenti-C-Myc-DDK
- pLenti-C-mGFP
- pDONR223
- pLenti-U6-sgRNA-PGK-Neo
- pLenti-U6-sgRNA-SFFV-Cas9-2A-Puro
- pPB-C-His
- pPB-N-His
- pGFP-V-RS
- pRFP-C-RS
- orf clones - Search results for 108 available HCLS1 gene related products
- Overview of 108 available HCLS1 gene related products
- Recommended
- pCMV6-AC
- pCMV6-Entry
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- pLenti-U6-sgRNA-SFFV-Cas9-2A-Puro
- pPB-C-His
- pPB-N-His
- pGFP-V-RS
- pRFP-C-RS
- pCMV6-AC
- pCMV6-Entry
- pLenti-C-Myc-DDK
- pLenti-C-mGFP
- pDONR223
- pLenti-U6-sgRNA-PGK-Neo
- pLenti-U6-sgRNA-SFFV-Cas9-2A-Puro
- pPB-C-His
- pPB-N-His
- pGFP-V-RS
- pRFP-C-RS
- genomics-online: gRNA clones - Search results for 108 available HCLS1 gene related products
- Overview of 108 available HCLS1 gene related products
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- pCMV6-AC
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- pLenti-C-mGFP
- pDONR223
- pLenti-U6-sgRNA-PGK-Neo
- pLenti-U6-sgRNA-SFFV-Cas9-2A-Puro
- pPB-C-His
- pPB-N-His
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- pRFP-C-RS
- genomics-online: primer clones - Search results for 108 available HCLS1 gene related products
- Overview of 108 available HCLS1 gene related products
- Recommended
- pCMV6-AC
- pCMV6-Entry
- pLenti-C-Myc-DDK
- pLenti-C-mGFP
- pDONR223
- pLenti-U6-sgRNA-PGK-Neo
- pLenti-U6-sgRNA-SFFV-Cas9-2A-Puro
- pPB-C-His
- pPB-N-His
- pGFP-V-RS
- pRFP-C-RS
- pCMV6-AC
- pCMV6-Entry
- pLenti-C-Myc-DDK
- pLenti-C-mGFP
- pDONR223
- pLenti-U6-sgRNA-PGK-Neo
- pLenti-U6-sgRNA-SFFV-Cas9-2A-Puro
- pPB-C-His
- pPB-N-His
- pGFP-V-RS
- pRFP-C-RS
- genomics-online: shRNA clones - Search results for 108 available HCLS1 gene related products
- Overview of 108 available HCLS1 gene related products
- Recommended
- pCMV6-AC
- pCMV6-Entry
- pLenti-C-Myc-DDK
- pLenti-C-mGFP
- pDONR223
- pLenti-U6-sgRNA-PGK-Neo
- pLenti-U6-sgRNA-SFFV-Cas9-2A-Puro
- pPB-C-His
- pPB-N-His
- pGFP-V-RS
- pRFP-C-RS
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- pCMV6-Entry
- pLenti-C-Myc-DDK
- pLenti-C-mGFP
- pDONR223
- pLenti-U6-sgRNA-PGK-Neo
- pLenti-U6-sgRNA-SFFV-Cas9-2A-Puro
- pPB-C-His
- pPB-N-His
- pGFP-V-RS
- pRFP-C-RS
Sources for YWHAB Gene
- (1) GeneCards
- (2) HGNC
- (3) EntrezGene
- (4) Swiss-Prot
- (5) Ensembl
- (6) OMIM
- (7) GeneLoc
- (8) Gene Wiki
- (9) UCSC
- (10) PhosphoSitePlus
- (11) GO
- (12) TrEMBL
- (13) InterPro
- (14) ProtoNet
- (15) Blocks
- (16) MGI
- (17) IUBMB
- (18) KEGG
- (19) MINT
- (20) STRING
- (21) IntAct
- (22) Novoseek
- (23) PharmGKB
- (24) DrugBank
- (25) HMDB
- (26)