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YWHAB Gene

protein-coding GIFtS: 72

GC20P042947

tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, beta polypeptide
Symbol approved by the HUGO Gene Nomenclature Committee (HGNC) database

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc , and/or ⁷Ensembl, ⁸miRBase)
About This Section

Aliases
GW128 ^²
HS1 ^²
KCIP-1 ^², ³
OTTHUMP00000031075 ^²
OTTHUMP00000031076 ^²

Descriptions
14-3-3 protein beta/alpha ^²
Protein 1054 ^², ³
Protein kinase C inhibitor protein 1 ^³
brain protein 14-3-3, beta isoform ^²
protein kinase C inhibitor protein-1 ^²
tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, beta polypeptide ^²

External Ids
HGNC: 12849¹
Entrez Gene: 7529²
UniProtKB: P31946³
Ensembl: ENSG00000166913⁷

Search outside databases for aliases for YWHAB gene

Previous GC identifers: GC20P043242 GC20P043202 GC20P044152 GC20P044199

(According to Entrez Gene, Wikipedia's Gene Wiki,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

EntrezGene summary for YWHAB:

This gene encodes a protein belonging to the 14-3-3 family of proteins, members of which mediate

signal transduction by binding to phosphoserine-containing proteins. This highly conserved protein

family is found in both plants and mammals. The encoded protein has been shown to interact with

RAF1 and CDC25 phosphatases, suggesting that it may play a role in linking mitogenic signaling and

the cell cycle machinery. Two transcript variants, which encode the same protein, have been

identified for this gene. [provided by RefSeq]

UniProtKB/Swiss-Prot: 1433B_HUMAN, P31946

Function: Adapter protein implicated in the regulation of a large spectrum of both general and

specialized signaling pathway. Binds to a large number of partners, usually by recognition of a

phosphoserine or phosphothreonine motif. Binding generally results in the modulation of the

activity of the binding partner. Negative regulator of osteogenesis

Gene Wiki entry for YWHAB

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 36),
and/or miRBase,
Genomic Views according to UCSC and Ensembl, Transcription factor binding sites according to SABiosciences)
About This Section

Genomic View:

UCSC Golden Path with GeneCards custom track

Transcription factor binding sites upstream to the YWHAB gene

Entrez Gene cytogenetic band: 20q13.1 Ensembl cytogenetic band: 20q13.12 HGNC cytogenetic band: 20q13.1

YWHAB Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)

GeneLoc gene densities for chromosome 20 GeneLoc Exon Structure

GeneLoc location for GC20P042947: (about GC identifiers)

Start:	42,947,758 bp from pter
End:	42,970,575 bp from pter
Size:	22,818 bases
Orientation:	plus strand

RefSeq DNA sequence:

NC_000020.9 NT_011362.9

(According to ¹UniProtKB, and/or Ensembl, Phosphorylation sites according to ²Phosphosite, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Enzo Life Sciences, Abnova, OriGene and/or, Abcam,
Biochemical Assays by Invitrogen, Millipore, R&D Systems, Cell Signaling Technology, and/or Enzo Life Sciences, Ontologies according to Gene Ontology Consortium 01 Apr 2009 and Entrez Gene, Antibodies by Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Cell Signaling Technology, Abcam, Abnova, and/or Novus Biologicals)
About This Section

UniProtKB/Swiss-Prot: 1433B_HUMAN, P31946 (See protein sequence)

Recommended Name: 14-3-3 protein beta/alpha

Size: 246 amino acids; 28082 Da

Subunit: Homodimer. Interacts with SSH1 and TORC2/CRTC2. Interacts with ABL1; the interaction

results in cytoplasmic location of ABL1 and inhition of cABL-mediated apoptosis. Interacts with

ROR2 (dimer); the interaction results in phosphorylation of YWHAB on tyrosine residues

Subcellular location: Cytoplasm. Melanosome. Note=Identified by mass spectrometry in melanosome

fractions from stage I to stage IV

PDB structure from and Proteopedia :

2BQ0 (3D)

2C23 (3D)

Alternative initiation: 2 isoforms: P31946-1 P31946-2

Post-translational modifications:

The alpha, brain-specific form differs from the beta form in being phosphorylated (By similarity)¹

Isoform Short contains a N-acetylmethionine at position 1 (By similarity)¹

View phosphorylation sites using PhosphoSite²

REFSEQ proteins (2 alternative transcripts):

NP_003395.1 NP_647539.1

ENSEMBL proteins:

ENSP00000361930 ENSP00000300161

Human Recombinant Proteins

	Browse Drug Discovery Central at Invitrogen for human recombinant proteins
	Browse Purified and Recombinant Proteins at Millipore
	Browse Human Recombinant Proteins at Sigma-Aldrich
	Browse R&D Systems for human recombinant proteins
	Enzo Life Sciences proteins for YWHAB
	Recombinant Proteins from Abcam (14-3-3 alpha + beta, 14-3-3, 14-3-3 beta + epsilon + zeta, 14-3-3 beta, 14-3-3 beta + zeta)
	Human Recombinant Proteins from Abnova (YWHAB)

OriGene Purified Recombinant Human Proteins (see all 2): YWHAB

5/6 Gene Ontology (GO) cellular component terms (links to tree view) (see all 6 ):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005634	nucleus	IDA	18029348
GO:0005737	cytoplasm	IDA	12963375
GO:0005813	centrosome	IDA	18029348
GO:0005829	cytosol	EXP	9069260 10195903 12657644
GO:0042470	melanosome	IEA	--

About this table

Antibodies for YWHAB:

	Browse Antibodies Central at Invitrogen
	Millipore Mono- and Polyclonal Antibodies for the study of YWHAB
	Sigma-Aldrich Antibodies for YWHAB
	R&D Systems Antibodies for YWHAB (14-3-3 beta)
	Cell Signaling Technology (CST) Antibodies for YWHAB (14-3-3 beta/alpha)
	Antibodies from Abcam (14-3-3 alpha + beta, 14-3-3, 14-3-3 beta + epsilon + zeta, 14-3-3 beta, 14-3-3 beta + zeta), each with their Abpromise^SM
	Monoclonal and Polyclonal Antibodies from Abnova (YWHAB)
	Novus Biologicals Antibodies for YWHAB

Assays for YWHAB:

	Browse Invitrogen for biochemical assays
	Browse Kits and Assays available from Millipore
	Browse R&D Systems for biochemical assays
	Browse biochemical assays available from Enzo Life Sciences

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

Graphical View of Domain Structure for InterPro Entry P31946

ProtoNet protein and cluster: P31946

1 Blocks protein family: IPB000308 14-3-3 protein

UniProtKB/Swiss-Prot: 1433B_HUMAN, P31946

Similarity: Belongs to the 14-3-3 family

(According to MGI Jun 06 2009, UniProtKB, IUBMB,and/or Genatlas,
shRNA from OriGene, Sigma-Aldrich, RNAi from Sigma-Aldrich,
RNAi Products, Clones, and Q-PCR Products from Invitrogen, Millipore, OriGene, and/or Abnova, siRNAs from Applied Biosystems, SYBR primers from OriGene, Cell-based Assays from Millipore, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
About This Section

Inhib. RNA:		Invitrogen RNAi Products for gene knock-down (YWHAB)
		Browse for Gene Knock-down Tools from Millipore
		Abnova Chimera RNAi Products for Gene knock-down (YWHAB)

OriGene 29mer shRNA kit in GFP-retroviral vectors (see all 2): NM_139323

Applied Biosystems Silencer® siRNAs for YWHAB

Sigma-Aldrich siRNA for YWHAB

Sigma-Aldrich shRNA for YWHAB

Explore Sigma-Aldrich super-pooled esiRNAs

Clones:		Invitrogen Clones for YWHAB
		Browse Clones for the Expression of Recombinant Proteins Available from Millipore

OriGene GFP tagged cDNA clones in CMV expression vector (see all 2): NM_003404
Myc/DDK tagged cDNA clones in CMV expression vector (see all 2): NM_003404
untagged cDNA clones in CMV expression vector (see all 2): NM_003404

Primers:

Browse Quantitative PCR Central at Invitrogen for Q-PCR LUX™ Primers

OriGene genome-wide validated SYBR primer pairs: NM_139323

UniProtKB/Swiss-Prot: 1433B_HUMAN, P31946

Function: Adapter protein implicated in the regulation of a large spectrum of both general and

specialized signaling pathway. Binds to a large number of partners, usually by recognition of a

phosphoserine or phosphothreonine motif. Binding generally results in the modulation of the

activity of the binding partner. Negative regulator of osteogenesis

Genatlas biochemistry entry for YWHAB:

tyrosine 3-monooxygenase/trytophan 5 monooxygenase activation protein,14-3-3 beta protein,including

the phosphorylated form YWHAA (alpha),multifunctional regulator involved in cell-cyle control

(checkpoint) and signal transduction,inhibitor of apoptosis through inhibiting the activation of

p38 MAP kinase

2 Gene Ontology (GO) molecular function terms (links to tree view):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0019899	enzyme binding	IPI	17255105
GO:0019904	protein domain specific binding	IPI	11984006

About this table

(Pathways according to Invitrogen (maps by GeneGo), Millipore, Cell Signaling Technology, Sigma-Aldrich, KEGG and/or UniProtKB,
Sets of similar genes according to GeneDecks, Proteins Network according to SABiosciences, Interactions according to ¹UniProtKB, ²MINT, and/or ³STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
About This Section

5 Sigma-Aldrich "Your Favorite Gene" Pathways for YWHAB (Your Favorite Gene powered by Ingenuity)

Cell Cycle: G2/M DNA Damage Checkpoint Regulation
PI3K/AKT Signaling
14-3-3-mediated Signaling
IGF-1 Signaling
ERK/MAPK Signaling

GeneDecks YWHAB for the pathways selected above

About GeneDecksing

Gene Network Central^TM Interacting Genes and Proteins Network for YWHAB

5/181 Interacting proteins for YWHAB (ENSP00000361930³ P31946^{1, 2}) via UniProtKB, MINT, and/or STRING (see all 181 )

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
AKAP13	Q12802¹	STRING (score=.753) EBI-359815, EBI-1373806
CDKN1B	P46527¹	STRING (score=.96) EBI-359815, EBI-519280
CSNK2A1P	P68400¹^,²	EBI-359815, EBI-347804 MINT-50947
RACGAP1P	Q9H0H5¹^,²	EBI-359815, EBI-717233 MINT-50978
RAF1	P04049¹	STRING (score=.999) EBI-359815, EBI-365996

About this table

5 Gene Ontology (GO) biological process terms (links to tree view):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0006605	protein targeting	IEA	--
GO:0007265	Ras protein signal transduction	EXP	11520933
GO:0008633	activation of pro-apoptotic gene products	EXP	15231831
GO:0035308	negative regulation of protein amino acid dephosphorylation	IDA	17255105
GO:0043085	positive regulation of catalytic activity	IDA	17255105

About this table

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, Sigma-Aldrich, Tocris Bioscience, and/or Novoseek and Drugs according to Enzo Life Sciences and/or PharmGKB)
About This Section

Enzo Life Sciences drugs & compounds for YWHAB

Browse Small Molecules at Sigma-Aldrich

Compounds for YWHAB available from Tocris Bioscience

Compound	Action	CAS number
Difopein	High affinity inhibitor of 14.3.3 proteins; induces apoptosis	[396834-58-5]
R18	Inhibitor of 14.3.3 proteins; induces apoptosis	[211364-78-2]

About this table

(GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 219 Homo sapiens; Jun 2 2009) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView,
non coding RNAs according to RNAdb,
ESTs according to GeneTide,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from Invitrogen, Millipore, and/or Abnova,
siRNAs from Applied Biosystems, Sigma-Aldrich,
shRNA from Sigma-Aldrich, OriGene,
Tagged/untagged cDNA clones from OriGene,
Expression Assays from Applied Biosystems)
About This Section

Inhib. RNA:		Invitrogen RNAi Products for gene knock-down (YWHAB)
		Browse for Gene Knock-down Tools from Millipore
		Abnova Chimera RNAi Products for Gene knock-down (YWHAB)

OriGene 29mer shRNA kit in GFP-retroviral vectors (see all 2): NM_139323

Sigma-Aldrich siRNA for YWHAB

Sigma-Aldrich shRNA for YWHAB

Explore Sigma-Aldrich super-pooled esiRNAs

Applied Biosystems Silencer® siRNAs:

NM_003404 NM_139323

REFSEQ mRNAs for YWHAB gene (2 alternative transcripts):

NM_003404.3 NM_139323.2

Applied Biosystems TaqMan ® Gene Expression Assays:

NM_003404 NM_139323

               OriGene GFP tagged cDNA clones in CMV expression vector (see all 2): NM_003404
                                 Myc/DDK tagged cDNA clones in CMV expression vector (see all 2): NM_003404
                                 untagged cDNA clones in CMV expression vector (see all 2): NM_003404

Additional cDNA sequence:

AB209759.1 AB451260.1 AB451386.1 AF064847.1 AF107406.1 AK292717.1 AL834170.1 BC001359.2

BC010352.1 CR595602.1 CR603709.1 CR614687.1 X57346.1

24/43 DOTS entries (see all 43 ):

DT.75122682 DT.92325870 DT.100059833 DT.100883297 DT.100883300 DT.100883284 DT.100883281 DT.87077844

DT.92007444 DT.120826031 DT.95256702 DT.95118446 DT.100883292 DT.100059820 DT.100883274 DT.95151410

DT.95151426 DT.120826094 DT.91772166 DT.100883277 DT.100883289 DT.95151421 DT.99977735 DT.100883266

24/1367 AceView cDNA sequences (see all 1367 ):

BG166756 BF111494 AW192674 T24802 BM759292 AA664166 BM552049 BU184514

Z36770 BM842747 T34258 AA167429 AA857896 CR614687 N22263 AA400553

BM767139 AI214594 BQ218086 BU732913 AI283942 AI815029 BM834089 BG249474

highest scoring ESTs for YWHAB:

X57346 AA055810 AA056434 AA070440 AA074917 AA075401 AA075468 AA088416 AA088539 AA100475

Unigene Cluster for YWHAB:

Tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, beta polypeptide

Hs.643544 [show with all ESTs]

Unigene Representative Sequence: AB209759

GeneLoc Exon Structure

5/10 Alternative Splicing Database (ASD) splice patterns (SP) for YWHAB (see all 10 )

ExUns:	1a	·	1b	^	2	^	3a	·	3b	^	4a	·	4b	·	4c	·	4d	^	5a	·	5b	·	5c	^	6a	·	6b	^	7a	·	7b	^	8	^	9a	·	9b	·	9c
SP1:					-		-										-		-		-		-
SP2:					-		-		-								-		-		-		-
SP3:
SP4:																	-
SP5:							-

About this scheme

ECgene alternative splicing isoforms for YWHAB

2 Ensembl transcripts including schematic representations:

ENST00000372839 ENST00000353703

(Experimental results according to ¹GeneNote and GNF BioGPS,
probe sets-to-genes annotations according to ²GeneAnnot , ³GeneTide , Sets of similar genes according to GeneDecks, Electronic Northern calculations according to data from UniGene (Build 219 Homo sapiens), SAGE tags according to CGAP, plus additional links to SOURCE, and/or GNF BioGPS, and/or EXPOLDB, and/or UniProtKB,
Expression Assays from Applied Biosystems )
About This Section

YWHAB expression in normal and diseased human tissues

Applied Biosystems TaqMan ® Gene Expression Assays for YWHAB

¹ / ² / ³

7 probe-sets matching YWHAB gene

Affymetrix probe-set	Array	# genes	Sensitivity	Specificity	Correlation	Length	Gb_Accession	Consensus	Uniqueness	Score	Rank
Affymetrix probe-set	Array	GeneAnnot data			GeneNote data		GeneTide data
32324_at²^{, 3}	U95-A	2	1.00	0.94	1.00	1.00	X57346	1.00	1.00	1.00	1
217717_s_at²^{, 3}	U133-A	1	1.00	1.00	--	--	BF246499	0.80	1.00	0.91	1
217718_s_at²^{, 3}	U133-A	1	1.00	1.00	--	--	NM_014052	0.20	1.00	0.72	1
208743_s_at²^{, 3}	U133-A	2	1.00	0.95	--	--	BC001359	0.80	1.00	0.91	1
217717_s_at²	U133Plus2	1	1.00	1.00	--	--	--	--	--	--	--
217718_s_at²	U133Plus2	1	1.00	1.00	--	--	--	--	--	--	--
208743_s_at²	U133Plus2	2	1.00	0.95	--	--	--	--	--	--	--

About this table

Data from

(Publications) and GNF BioGPS
About these images
About these images

CGAP SAGE TAG: CAGTTACTTA

SOURCE GeneReport for Unigene cluster: Hs.643544
Expression variation in blood from EXPOLDB for YWHAB

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD and/or ⁵MGI Jun 06 2009, with possible further links to Flybase and/or WormBase, Gene Trees according to Ensembl)
About This Section

Orthologs for YWHAB gene from 5/11 species (see all 11 )

Organism	Gene	Locus	Description	Human Similarity	NCBI accessions
dog (Canis familiaris)	YWHAB¹	--	tyrosine 3-monooxygenase/tryptophan 5-monooxygenase more	93.72(n) 100(a)	477237 XM_847661.1 XP_852754.1
cow (Bos taurus)	YWHAB¹	--	tyrosine 3-monooxygenase/tryptophan 5-monooxygenase more	92.01(n) 100(a)	286863 NM_174794.2 NP_777219.2
rat (Rattus norvegicus)	Ywhab¹	--	tyrosine 3-monooxygenase/tryptophan 5-monooxygenase more	91.33(n) 98.37(a)	56011 NM_019377.1 NP_062250.1
mouse (Mus musculus)	Ywhab^{1, 5}	2⁵	tyrosine 3-monooxygenase/tryptophan 5-monooxygenase more^{1, 5}	90.65(n)¹ 98.78(a)¹	54401¹ NM_018753.4¹ NP_061223.2¹ AF058797⁵ AI060694⁵ (see all 48)
chicken (Gallus gallus)	YWHAB¹	--	tyrosine 3-monooxygenase/tryptophan 5-monooxygenase more	84.7(n) 97.95(a)	419190 NM_001006289.1 NP_001006289.1

About this table Species with no ortholog for YWHAB

ENSEMBL Gene Tree for YWHAB

(Paralogs according to ¹HomoloGene
and ²Ensembl, Pseudogenes according to ³Pseudogene.org)
About This Section

Paralogs for YWHAB gene

YWHAQ² SFN² YWHAZ²

Pseudogenes

2 related pseudogenes

(According to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, and UniProtKB, Linkage Disequilibrium by HapMap, Genotyping Reagents from Applied Biosystems)
About This Section

10/166 NCBI SNPs in YWHAB are shown (see all 166 )
(Click for Applied Biosystems TaqMan ® Genotyping Assay) (see all 69)

AB	SNP ID	Valid	Chr 20 pos	Sequence	Recs	AA Chg	Type	More	Recs	Allele freq	Pop	Total sample	More
AB	Genomic Data				Transcription Data				Allele Frequencies
				--	--	--		--	--				--
	rs3092669^1,2	A,C,F,H	42946845(+)	`ACCTTC/GAGAGG`	2	--	ng5¹		4		EU EA WA	416
	rs6876^1,2	C,F,H,O	42968515(+)	`TGATCT/CGTTCA`	2	--	ut3¹		6		MN NA EU	622
--	rs8356^1,2	A,C,F	42969869(+)	`CAACAC/TGGTGT`	2	--	ut3¹ ese³		4		MN NA EA	1862
	rs2425677^1,2	A,C,F	42971071(+)	`AAAAAA/TATCAG`	2	--	ng3¹		2		NA	182
--	rs6031847^1,2	A,C	42947617(+)	`tgcaaC/Tcctgc`	2	--	ng5¹		0	--	--	--	--
--	rs6031849^1,2	A,C	42947751(+)	`GTGGCG/TATCGG`	2	--	ng5¹ ese³		0	--	--	--	--
	rs2425676^1,2	A,C	42970871(+)	`TATTCA/GAGCCC`	2	--	ng3¹		0	--	--	--	--
--	rs6017440^1,2	F,H	42946760(+)	`agattG/Atgaca`	2	--	ng5¹		3		EU EA	272
--	rs3091409^1,2	A,C	42947028(+)	`tgcagG/Tggcat`	2	--	ng5¹		0	--	--	--	--
--	rs6031848^1,2	A,C	42947624(+)	`ctgccC/Tttcgc`	2	--	ng5¹		0	--	--	--	--

About this table

HapMap Linkage Disequilibrium images for YWHAB (up to first 250kb)

(in which this Gene is Involved, According to OMIM, UniProtKB, PharmGKB, Genatlas, GeneTests, Blood group antigen gene mutations by BGMUT, HGMD, GAD, HuGE Navigator, BCGD, and/or TGDB.)
About This Section

OMIM: 601289

Genetic Association Database: YWHAB
Human Genome Epidemiology Navigator: YWHAB (1 document)

(Possibly Related Articles in Doctor's Guide)
About This Section

(in PubMed. Associations of this gene to articles via ¹Novoseek, ²HGNC, ³Entrez Gene, ⁴UniProtKB/Swiss-Prot, ⁵UniProtKB/TrEMBL, ⁶GAD, and/or ⁷PharmGKB)
About This Section

10/115 PubMed articles for YWHAB gene (see all 115 ):

Homodimerization of Ror2 tyrosine kinase receptor induces 14-3-3(beta) phosphorylation and promotes osteoblast differentiation and bone formation. (PubMed id 17717073)^{3, 4} Liu Y....Billiard J. (2007)
Proteomic and bioinformatic characterization of the biogenesis and function of melanosomes. (PubMed id 17081065)^{3, 4} Chi A....Hunt D.F. (2006)
A pathway of neuregulin-induced activation of cofilin-phosphatase Slingshot and cofilin in lamellipodia. (PubMed id 15159416)^{3, 4} Nagata-Ohashi K.... Mizuno K. (2004)
The CREB coactivator TORC2 functions as a calcium- and cAMP-sensitive coincidence detector. (PubMed id 15454081)^{3, 4} Screaton R.A.... Montminy M. (2004)
Association of a four-amino acid residue insertion polymorphism of the HS1 gene with systemic lupus erythematosus: molecular and functional analysis. (PubMed id 15022330)^{3, 6} Otsuka J....Harada M. (2004)
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)^{3, 4} Gerhard D.S....Malek J. (2004)
Exploring proteomes and analyzing protein processing by mass spectrometric identification of sorted N-terminal peptides. (PubMed id 12665801)^{3, 4} Gevaert K.... Vandekerckhove J. (2003)
The DNA sequence and comparative analysis of human chromosome 20. (PubMed id 11780052)^{3, 4} Deloukas P....Rogers J. (2001)
Assignment of the human genes encoding 14,3-3 Eta (YWHAH) to 22q12, 14-3-3 zeta (YWHAZ) to 2p25.1-p25.2, and 14-3-3 beta (YWHAB) to 20q13.1 by in situ hybridization. (PubMed id 8617504)^{2, 3} Tommerup N. and Leffers H. (1996)
Molecular cloning and expression of the transformation sensitive epithelial marker stratifin. A member of a protein family that has been involved in the protein kinase C signalling pathway. (PubMed id 8515476)^{3, 4} Leffers H.... Celis J.E. (1993)

(in PubMed, OMIM, and NCBI Bookshelf)
About This Section

		AND	OR
Aliases
Free Text

Query String		PubMed OMIM NCBI Bookshelf
	(Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, and/or H-InvDB)
About This Section

Entrez Gene: 7529	HGNC: 12849	AceView: YWHAB	Ensembl:ENSG00000166913	euGenes: HUgn7529
ECgene: YWHAB	H-InvDB: YWHAB

(According to HUGE)
About This Section

(According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section

Licensable Technologies for YWHAB
(Available from WIS Yeda, Salk, Tufts)

About This Section

(Reagents available from Applied Biosystems, Antibodies and assays by Cell Signaling Technology, Abcam, Novus Biologicals,
Sigma-Aldrich, R&D Systems, Millipore, Abnova, and/or Invitrogen, Clones available from OriGene,and/or Invitrogen, Drugs and/or compounds by Sigma-Aldrich,
Enzo Life Sciences, and/or Tocris Bioscience)
About This Section

Products for YWHAB:

TaqMan ® Gene Expression Assays

TaqMan ® Genotyping Assays

Free SNP selection tool

Invitrogen iPath Pathways	Invitrogen BLOCK-iT™ RNAi
Invitrogen Antibodies	Invitrogen Assays
Invitrogen Clones	Invitrogen Q-PCR Products
Invitrogen Human Recombinant Kinases	Invitrogen Custom Antibody and Peptide Service
Invitrogen Proteins / Assays / Screening Services	Search Invitrogen catalog for YWHAB-related products

	Millipore Custom Antibody & Bulk Services
	Millipore Preclinical / Clinical Development Services
	Millipore Immunoassay Services
	Millipore Target Screening & Profiling Services

	Predesigned and custom siRNAs for YWHAB		Antibodies for YWHAB
	Explore super-pooled esiRNAs		Browse proteins at Sigma-Aldrich
	Lentivirus-delivered shRNAs for YWHAB		Browse small molecules at Sigma-Aldrich
	"Your Favorite Gene" Pathways		feedback

	Antibodies		Primer Pairs
	Cell Culture Products		ELISAs
	Flow Cytometry Kits		Protease Activity Assays & Reagents
	Cell Selection/Detection Kits & Reagents		ELISA/Assay Development Kits & Reagents
	Multiplex/Array Assay Kits & Reagents		ELISpot Kits & Development Modules
	Recombinant & Natural Proteins

	Recombinant Proteins (YWHAB)
	Antibodies (YWHAB)
	Chimera RNAi (YWHAB)
	Custom Service for Mouse Mab
	Custom Service for Rabbit Pab from Full-length Protein

Antibodies & Assays for YWHAB (14-3-3 beta/alpha)

	Recombinant Proteins (14-3-3 alpha + beta, 14-3-3, 14-3-3 beta + epsilon + zeta, 14-3-3 beta, 14-3-3 beta + zeta)
	Antibodies (14-3-3 alpha + beta, 14-3-3, 14-3-3 beta + epsilon + zeta, 14-3-3 beta, 14-3-3 beta + zeta)

	Tagged/untagged cDNA clones
	Validated SYBR primer pairs
	Purified proteins from HEK293T cells
	Western blot validated antibodies
	shRNA in GFP-retroviral vector

Tocris compounds for YWHAB

	Drugs/Proteins for YWHAB
	Search www.enzolifesicences.com for proteins, assays, substrates, inhibitors & antibodies

Antibodies for YWHAB

GeneCards Homepage - Last full update: 2 Jul 2009 Incremental update: 13 Oct 2009

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YWHAB Gene at Home site.
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YWHAB Gene

protein-coding GIFtS: 72

Aliases &
Descriptions
for YWHAB

Summaries
for YWHAB

Genomic Location
for YWHAB

Proteins
for YWHAB

Protein Domains/
Families
for YWHAB

Gene Function
for YWHAB

Pathways & Interactions
for YWHAB

Drugs & Compounds
for YWHAB

Transcripts
for YWHAB

Expression
for YWHAB

Orthologs
for YWHAB

Paralogs
for YWHAB

SNPs/Variants
for YWHAB

Disorders & Mutations
for YWHAB

Medical News
for YWHAB

Publications
for YWHAB

Search for YWHAB

Genome Databases showing YWHAB

Other Databases showing YWHAB

Specialized Databases showing YWHAB

Licensable Technologies
for YWHAB

Services
for YWHAB

Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

YWHAB Gene

protein-coding GIFtS: 72

Aliases & Descriptionsfor YWHAB

Summariesfor YWHAB

Genomic Locationfor YWHAB

Proteinsfor YWHAB

Protein Domains/Familiesfor YWHAB

Gene Functionfor YWHAB

Pathways & Interactionsfor YWHAB

Drugs & Compoundsfor YWHAB

Transcriptsfor YWHAB

Expression for YWHAB

Orthologsfor YWHAB

Paralogsfor YWHAB

SNPs/Variantsfor YWHAB

Disorders & Mutationsfor YWHAB

Medical Newsfor YWHAB

Publicationsfor YWHAB

Search for YWHAB

Genome Databases showing YWHAB

Other Databases showing YWHAB

Specialized Databases showing YWHAB

Licensable Technologiesfor YWHAB

Servicesfor YWHAB

Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

Aliases &
Descriptions
for YWHAB

Summaries
for YWHAB

Genomic Location
for YWHAB

Proteins
for YWHAB

Protein Domains/
Families
for YWHAB

Gene Function
for YWHAB

Pathways & Interactions
for YWHAB

Drugs & Compounds
for YWHAB

Transcripts
for YWHAB

Expression
for YWHAB

Orthologs
for YWHAB

Paralogs
for YWHAB

SNPs/Variants
for YWHAB

Disorders & Mutations
for YWHAB

Medical News
for YWHAB

Publications
for YWHAB

Licensable Technologies
for YWHAB

Services
for YWHAB