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Category Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21

GIFtS
-

YWHAB Gene

protein-coding GIFtS: 69
GCID: GC20P043515

Tyrosine 3-Monooxygenase/Tryptophan 5-Monooxygenase Activation...

(Previous names: tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation...)
(Previous symbol: YWHAA)

Alzheimer's & Parkinson's Diseases Congress

21 related diseases
at

MalaCards

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc, ⁷Ensembl, ⁸DME, ⁹miRBase, ¹⁰fRNAdb, ¹²H-InvDB, ¹³NCBI, ¹⁴NONCODE, and/or ¹⁵RNAdb)
About This Section

Aliases
Tyrosine 3-Monooxygenase/Tryptophan 5-Monooxygenase Activation Protein, Beta Polypeptide¹ ²		14-3-3 Beta¹
YWHAA¹ ²		14-3-3 Protein Beta/Alpha²
Tyrosine 3-Monooxygenase/Tryptophan 5-Monooxygenase Activation Protein, Alpha Polypeptide¹ ²		GW128²
14-3-3 Alpha¹ ²		HS1²
Protein 1054² ³		Brain Protein 14-3-3, Beta Isoform²
Protein Kinase C Inhibitor Protein 1² ³		Protein Kinase C Inhibitor Protein-1²
KCIP-1² ³

External Ids:	HGNC: 12849¹	Entrez Gene: 7529²	Ensembl: ENSG00000166913⁷	OMIM: 601289⁵	UniProtKB: P31946³

Export aliases for YWHAB gene to outside databases

Previous GC identifers: GC20P043242 GC20P043202 GC20P044152 GC20P044199 GC20P042947 GC20P040256

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for YWHAB Gene:

This gene encodes a protein belonging to the 14-3-3 family of proteins, members of which mediate signal

transduction by binding to phosphoserine-containing proteins. This highly conserved protein family is found in

both plants and mammals. The encoded protein has been shown to interact with RAF1 and CDC25 phosphatases,

suggesting that it may play a role in linking mitogenic signaling and the cell cycle machinery. Two transcript

variants, which encode the same protein, have been identified for this gene. (provided by RefSeq, Jul 2008)

GeneCards Summary for YWHAB Gene:

YWHAB (tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, beta polypeptide) is a protein-coding gene. Diseases associated with YWHAB include tuberous sclerosis complex, and tuberous sclerosis, and among its related super-pathways are Cell cycle and Signal transduction AKT signaling. GO annotations related to this gene include enzyme binding and protein domain specific binding. An important paralog of this gene is YWHAH.

UniProtKB/Swiss-Prot: 1433B_HUMAN, P31946

Function: Adapter protein implicated in the regulation of a large spectrum of both general and specialized

signaling pathways. Binds to a large number of partners, usually by recognition of a phosphoserine or

phosphothreonine motif. Binding generally results in the modulation of the activity of the binding partner.

Negative regulator of osteogenesis. Blocks the nuclear translocation of the phosphorylated form (by AKT1) of

SRPK2 and antagonizes its stimulatory effect on cyclin D1 expression resulting in blockage of neuronal apoptosis

elicited by SRPK2

summary for YWHAB Gene:

14.3.3 proteins are a group of highly conserved proteins that are involved in many vital cellular processes

such as metabolism, protein trafficking, signal transduction, apoptosis and cell cycle regulation. 14.3.3

proteins are phospho-serine/phospho-threonine binding proteins that have a diverse array of partners

including transcription factors, biosynthetic enzymes, cytoskeletal proteins, signalling molecules,

apoptosis factors and tumour suppressors. The 14.3.3 family consists of 7 isoforms; beta, gamma, epsilon,

sigma, zeta, tau and eta. 14.3.3 proteins are ubiquitously expressed and self assemble into homo- and

heterodimers, with the exception of 14.3.3sigma, which exclusively forms homodimers and is found in cells of

epithelial origin only. Each monomer contains an independent ligand-binding site, thus the 14.3.3 dimer can

interact with two target proteins simultaneously. 14.3.3 proteins are highly rigid structures and ligand

binding can induce conformational changes that alter the stability and/or catalytic activity of the ligand.

Furthermore, 14.3.3 protein binding can physically occlude sequence-specific or structural motifs on the

target that prevent molecular interactions and/or modulate the accessibility of a target protein to

modifying enzymes such as kinases, phosphatases and proteases. In addition, 14.3.3 proteins can act as a

scaffold molecule to anchor target proteins within close proximity of one another. 14.3.3 proteins represent

an integration point for proliferative, survival, apoptotic and stress signalling pathways. Members of the

14.3.3 protein family enhance the activity of many proteins with proliferative and/or survival functions,

such as Raf kinases, and antagonise the activity of proteins that promote cell death and senescence, such as

Bad, Bim and Bax. In contrast, 14.3.3sigma acts as a tumour suppressor and its expression is upregulated

coordinately with p53 and BRAC1. This isoform sequesters cdk1-cyclin B complexes in the cytoplasm, and thus

delays cell cycle progression. 14.3.3sigma is also a crucial regulator of translation during mitosis.

Because many 14.3.3 interactions are phosphorylation dependent, 14.3.3 proteins have been integrated into

the core regulatory pathways that are crucial for normal growth and development. 14.3.3 proteins are

directly involved in cellular processes such as cytokinesis, cell-contact inhibition, anchorage-independent

growth and cell adhesion, and it is these pathways that often become dysregulated in disease states such as

cancer.

Gene Wiki entry for YWHAB Gene

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section

RefSeq DNA sequence:

NC_000020.10 NT_011362.10 NC_018931.2

Regulatory elements:

SABiosciences Regulatory transcription factor binding sites in the YWHAB gene promoter:
MEF-2 E47 CREB MEF-2A POU2F1 FOXJ2 (long isoform) POU2F1a Hand1 FOXJ2 aMEF-2
Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: YWHAB promoter sequence

Search SABiosciences Chromatin IP Primers for YWHAB

Epigenetics:

QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat YWHAB

Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 20q13.1 Ensembl cytogenetic band: 20q13.12 HGNC cytogenetic band: 20q13.1

YWHAB Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
YWHAB gene location

GeneLoc information about chromosome 20 GeneLoc Exon Structure

GeneLoc location for GC20P043515: view genomic region (about GC identifiers)

Start:	43,514,317 bp from pter	End:	43,537,173 bp from pter
Size:	22,857 bases	Orientation:	plus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE ¹MOPED, ²PaxDb, and ³MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: 1433B_HUMAN, P31946 (See protein sequence)

Recommended Name: 14-3-3 protein beta/alpha

Size: 246 amino acids; 28082 Da

Subunit: Homodimer. Interacts with SAMSN1 and KRPCE (By similarity). Interacts with SSH1 and TORC2/CRTC2.

Interacts with ABL1; the interaction results in cytoplasmic location of ABL1 and inhibition of cABL-mediated

apoptosis. Interacts with ROR2 (dimer); the interaction results in phosphorylation of YWHAB on tyrosine residues.

Interacts with GAB2 and YAP1 (phosphorylated form). Interacts with the phosphorylated (by AKT1) form of SRPK2.

Interacts with PKA-phosphorylated AANAT

Subcellular location: Cytoplasm. Melanosome. Note=Identified by mass spectrometry in melanosome fractions from

stage I to stage IV

3 PDB 3D structures from and Proteopedia for YWHAB:

2BQ0 (3D)

2C23 (3D)

4DNK (3D)

Secondary accessions: A8K9K2 E1P616

Alternative initiation: 2 isoforms: P31946-1 P31946-2 (Contains a N-acetylmethionine at position 1 (By similarity))

Explore the universe of human proteins at neXtProt for YWHAB: NX_P31946

Explore proteomics data for YWHAB at MOPED

Post-translational modifications:

UniProtKB: The alpha, brain-specific form differs from the beta form in being phosphorylated (By similarity). Phosphorylated

on Ser-60 by protein kinase C delta type catalytic subunit in a sphingosine-dependent fashion (By similarity)

UniProtKB: Isoform Short contains a N-acetylmethionine at position 1 (By similarity)

View modification sites using PhosphoSitePlus

View neXtProt modification sites for NX_P31946

YWHAB Protein expression data from MOPED¹, PaxDb² and MAXQB³ : About this image

REFSEQ proteins (2 alternative transcripts):

NP_003395.1 NP_647539.1

ENSEMBL proteins:

ENSP00000300161 ENSP00000361930 ENSP00000394729 ENSP00000394558

Reactome Protein details: P31946
Human Recombinant Protein Products for YWHAB:

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	Novus Biologicals YWHAB Proteins Novus Biologicals YWHAB Lysates
	Sino Biological Recombinant Protein for YWHAB Browse Sino Biological Cell Lysates
	ProSpec Recombinant Protein for YWHAB
	Browse Proteins at Cloud-Clone Corp.

Gene Ontology (GO): 5/9 cellular component terms (GO ID links to tree view) (see all 9): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005634	nucleus	--	--
GO:0005737	cytoplasm	IDA	--
GO:0005829	cytosol	TAS	--
GO:0017053	transcriptional repressor complex	IEA	--
GO:0030659	cytoplasmic vesicle membrane	TAS	--

YWHAB for ontologies About GeneDecksing

YWHAB Antibody Products:

	EMD Millipore Mono- and Polyclonal Antibodies for the study of YWHAB
	R&D Systems Antibodies for YWHAB (14-3-3 beta)
	OriGene Antibodies for YWHAB OriGene Custom Antibody Services for YWHAB
	GenScript Custom Superior Antibodies Services for YWHAB
	Novus Biologicals YWHAB Antibodies
	Abcam antibodies for YWHAB
	Browse Antibodies at Cloud-Clone Corp.
	ThermoFisher Antibody for YWHAB
	LSBio Antibodies in human, mouse, rat for YWHAB

Assay Products for YWHAB:

	Browse Kits and Assays available from EMD Millipore
	OriGene Custom Assay Services for YWHAB
	Browse R&D Systems for biochemical assays
	GenScript Custom Assay Services for YWHAB
	Browse Enzo Life Sciences for kits & assays
	Browse ELISAs at Cloud-Clone Corp. Browse CLIAs at Cloud-Clone Corp.

(According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

3 InterPro protein domains:

IPR023410 14-3-3_domain

IPR000308 14-3-3

IPR023409 14-3-3_CS

Graphical View of Domain Structure for InterPro Entry P31946

ProtoNet protein and cluster: P31946

1 Blocks protein domain: IPB000308 14-3-3 protein

UniProtKB/Swiss-Prot: 1433B_HUMAN, P31946

Similarity: Belongs to the 14-3-3 family

YWHAB for domains About GeneDecksing

(According to ¹UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or ²DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
About This Section

Molecular Function:

UniProtKB/Swiss-Prot Summary: 1433B_HUMAN, P31946

Function: Adapter protein implicated in the regulation of a large spectrum of both general and specialized

signaling pathways. Binds to a large number of partners, usually by recognition of a phosphoserine or

phosphothreonine motif. Binding generally results in the modulation of the activity of the binding partner.

Negative regulator of osteogenesis. Blocks the nuclear translocation of the phosphorylated form (by AKT1) of

SRPK2 and antagonizes its stimulatory effect on cyclin D1 expression resulting in blockage of neuronal apoptosis

elicited by SRPK2

Genatlas biochemistry entry for YWHAB:

tyrosine 3-monooxygenase/trytophan 5 monooxygenase activation protein,14-3-3 beta protein,including the

phosphorylated form YWHAA (alpha),multifunctional regulator involved in cell-cyle control (checkpoint) and signal

transduction,inhibitor of apoptosis through inhibiting the activation of p38 MAP kinase

Gene Ontology (GO): 5/9 molecular function terms (GO ID links to tree view) (see all 9): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0003714	transcription corepressor activity	IEA	--
GO:0005515	protein binding	IPI	10713667
GO:0008022	protein C-terminus binding	IEA	--
GO:0019899	enzyme binding	IPI	17255105
GO:0019904	protein domain specific binding	IPI	11984006

YWHAB for ontologies About GeneDecksing

Animal Models:

inGenious Targeting Laboratory - Custom generated mouse model solutions for YWHAB

inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for YWHAB

genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for YWHAB

genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for YWHAB

miRNA Products:		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat YWHAB
		8/42 QIAGEN miScript miRNA Assays for microRNAs that regulate YWHAB (see all 42):
		hsa-miR-124* hsa-miR-4291 hsa-miR-429 hsa-miR-128 hsa-miR-759 hsa-miR-183* hsa-miR-1276 hsa-miR-200b

		SwitchGear 3'UTR luciferase reporter plasmid: YWHAB 3' UTR sequence

Inhib. RNA Products:		Browse for Gene Knock-down Tools from EMD Millipore
		OriGene RNAi products in human, mouse, rat for YWHAB
		QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat YWHAB

Gene Editing Products:			DNA2.0 Custom Protein Engineering Service for YWHAB
			Sirion Biotech Customized adenovirus for overexpression of YWHAB

Clone Products:		Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
		OriGene clones in human, mouse for YWHAB (see all 13) OriGene ORF clones in mouse, rat for YWHAB OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
		GenScript: all cDNA clones in your preferred vector (see all 2): YWHAB (NM_139323)
		Sino Biological Human cDNA Clone for YWHAB
		DNA2.0 Custom Codon Optimized Gene Synthesis Service for YWHAB
		Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat YWHAB
		Sirion Biotech Customized lentivirus for stable overexpression of YWHAB Customized lentivirus expression plasmids for stable overexpression of YWHAB

Cell Line Products:		GenScript Custom overexpressing Cell Line Services for YWHAB
		Search LifeMap BioReagents cell lines for YWHAB

In Situ Assay
Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for YWHAB

(Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to ¹UniProtKB, ²MINT, ³I2D, and/or ⁴STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
About This Section

SuperPaths for YWHAB About (see all 76)

See pathways by source

SuperPath

Selected contained pathways About (see all per SuperPath)

Cell cycle

Cell cycle

0.59

Cell cycle

0.59

Development IGF-RI signaling

Development IGF-RI signaling

0.49

Development IGF-1 receptor signaling

0.48

Cell cycle Role of 14-3-3 proteins in cell cycle regulation

Cell cycle Role of 14-3-3 proteins in cell cycle regulation

0.45

14-3-3 and Cell Cycle Regulation

0.45

Development Dopamine D2 receptor transactivation of EGFR

Apoptosis and survival BAD phosphorylation

0.41

BAD Phosphorylation

0.41

Signaling by FGFR

Downstream signaling of activated FGFR	0.92	Downstream signal transduction	0.90
Signaling by FGFR	0.92	Signaling by PDGF	0.85
Signaling by FGFR in disease	0.91	Signaling by EGFR	0.84
DAP12 signaling	0.91	Signaling by EGFR in Cancer	0.83

Pathways by source See SuperPaths
Show all pathways

5/7 EMD Millipore Pathways for YWHAB (see all 7)

	Cytoskeleton remodeling Role of PKA in cytoskeleton reorganisation
	Immune response Function of MEF2 in T lymphocytes
	Cell cycle Role of 14-3-3 proteins in cell cycle regulation
	G-protein signaling G-Protein alpha-12 signaling pathway
	Development Role of HDAC and calcium/calmodulin-dependent kinase (CaMK) in control of skeletal myogenesis

1 R&D Systems Pathway for YWHAB

Apoptosis Signaling Pathways

5/18 Downloadable PowerPoint Slides of QIAGEN Pathway Central Maps for YWHAB (see all 18)

	14-3-3 Induced Apoptosis
	DHA Signaling
	PKA Signaling
	ERK5 Signaling
	BDNF Pathway

4 Cell Signaling Technology (CST) Pathways for YWHAB

	MAP Kinase Signaling
	Apoptosis and Autophagy
	Cell Cycle / Checkpoint Control
	Tyrosine Kinases / Adaptors

2 Tocris Bioscience Pathways for YWHAB

	Insulin Pathway
	Apoptosis Pathway

5/7 GeneGo (Thomson Reuters) Pathways for YWHAB (see all 7)

	Apoptosis and survival BAD phosphorylation
	Development Role of HDAC and calcium/calmodulin-dependent kinase (CaMK) in control of skeletal myogenesis
	Development IGF-1 receptor signaling
	Cytoskeleton remodeling Role of PKA in cytoskeleton reorganisation
	Immune response Function of MEF2 in T lymphocytes

5/20 BioSystems Pathways for YWHAB (see all 20)

	Myometrial Relaxation and Contraction Pathways
	Cell cycle
	EGFR1 Signaling Pathway
	Calcium Regulation in the Cardiac Cell
	SIDS Susceptibility Pathways

5/70 Reactome Pathways for YWHAB (see all 70)

	SHC-related events
	SHC-mediated signalling
	Intrinsic Pathway for Apoptosis
	IRS-mediated signalling
	Signaling by PDGF

5/7 Kegg Pathways (Kegg details for YWHAB) (see all 7):

	Cell cycle
	Oocyte meiosis
	PI3K-Akt signaling pathway
	Hippo signaling pathway
	Hepatitis B

YWHAB for pathways About GeneDecksing

Interactions:

SABiosciences Gene Network Central^TM Interacting Genes and Proteins Network for YWHAB

STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

5/944 Interacting proteins for YWHAB (P31946^{1, 2, 3} ENSP00000300161⁴) via UniProtKB, MINT, STRING, and/or I2D (see all 944)

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
ENSG00000212866	P08107²^,³	MINT-50346 I2D: score=4
ENSG00000215328	P08107²^,³	MINT-50346 I2D: score=4
ENSG00000224501	P08107²^,³	MINT-50346 I2D: score=4
ENSG00000231555	P08107²^,³	MINT-50346 I2D: score=4
ENSG00000234475	P08107²^,³	MINT-50346 I2D: score=4

About this table

Gene Ontology (GO): 5/24 biological process terms (GO ID links to tree view) (see all 24): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0000165	MAPK cascade	TAS	--
GO:0000186	activation of MAPKK activity	TAS	--
GO:0006605	protein targeting	IEA	--
GO:0006915	apoptotic process	TAS	--
GO:0007173	epidermal growth factor receptor signaling pathway	TAS	--

YWHAB for ontologies About GeneDecksing

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
About This Section

YWHAB for compounds About GeneDecksing

Browse Small Molecules at EMD Millipore

Browse drugs & compounds from Enzo Life Sciences

Compounds for YWHAB available from Tocris Bioscience About this table

Compound	Action	CAS #
Difopein	High affinity inhibitor of 14.3.3 proteins; induces apoptosis	[396834-58-5]
R18	Inhibitor of 14.3.3 proteins; induces apoptosis	[211364-78-2]

2 HMDB Compounds for YWHAB About this table

Compound	Synonyms	CAS #	PubMed Ids
Sepiapterin	L-sepiapterin (see all 8)	17094-01-8	--
Zolpidem	Ambien (see all 7)	82626-48-0	--

1 Novoseek inferred chemical compound relationship for YWHAB gene About this table

Compound	-log (P-Val)	Hits	PubMed IDs for Articles with Shared Sentences (# sentences)
serine	28.2	1	16469478 (1)

Search CenterWatch for drugs/clinical trials and news about YWHAB / 1433B

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from EMD Millipore,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
About This Section

REFSEQ mRNAs for YWHAB gene (2 alternative transcripts):

NM_003404.4 NM_139323.3

Unigene Cluster for YWHAB:

Tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, beta polypeptide

Hs.643544 [show with all ESTs]

Unigene Representative Sequence: AB209759

7 Ensembl transcripts including schematic representations, and UCSC links where relevant:

ENST00000353703(uc002xmu.3) ENST00000479421 ENST00000372839(uc002xmt.3)

ENST00000428262 ENST00000445830 ENST00000477896 ENST00000479758

miRNA Products:		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat YWHAB
		8/42 QIAGEN miScript miRNA Assays for microRNAs that regulate YWHAB (see all 42):
		hsa-miR-124* hsa-miR-4291 hsa-miR-429 hsa-miR-128 hsa-miR-759 hsa-miR-183* hsa-miR-1276 hsa-miR-200b

		SwitchGear 3'UTR luciferase reporter plasmid: YWHAB 3' UTR sequence

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		QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat YWHAB
		QIAGEN QuantiFast Probe-based Assays in human, mouse, rat YWHAB

Additional mRNA sequence:

AB209759.1 AB451260.1 AB451386.1 AF064847.1 AF107406.1 AK292717.1 AL834170.1 BC001359.2

BC010352.1 X57346.1

24/49 DOTS entries (see all 49):

DT.75122682 DT.100883284 DT.87077844 DT.100883297 DT.92325870 DT.100883281 DT.100883300 DT.100059833

DT.92007444 DT.95256702 DT.120826031 DT.100883289 DT.95118446 DT.95151426 DT.100883292 DT.120826074

DT.100883274 DT.100059820 DT.95151410 DT.120826094 DT.91772166 DT.100883277 DT.95151421 DT.100883266

24/1367 AceView cDNA sequences (see all 1367):

CA950124 BM825717 BQ183152 BI870517 BM761438 BF718564 CB120809 AA075401

AA872095 BM839917 BM504251 BI838277 AW087348 N26423 BM552049 AA160338

AA845374 CB141648 BM464306 BM826353 BQ889847 T39564 AW511042 BM796664

GeneLoc Exon Structure

5/10 Alternative Splicing Database (ASD) splice patterns (SP) for YWHAB (see all 10) About this scheme

ExUns:	1a	·	1b	^	2	^	3a	·	3b	^	4a	·	4b	·	4c	·	4d	^	5a	·	5b	·	5c	^	6a	·	6b	^	7a	·	7b	^	8	^	9a	·	9b	·	9c
SP1:					-		-										-		-		-		-
SP2:					-		-		-								-		-		-		-
SP3:
SP4:																	-
SP5:							-

ECgene alternative splicing isoforms for YWHAB

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section

YWHAB expression in normal human tissues (normalized intensities) YWHAB embryonic expression: see
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS <intensity>^2/3
CGAP TAG: CAGTTACTTA

About this image

YWHAB expression in embryonic tissues and stem cells About this table

Data from LifeMap, the Embryonic Development and Stem Cells Database

5/32 selected tissues (see all 32) fully expand


Epithelium
vagina ; squamous epithelial cells

Uterus
uterus, post-menopause ; glandular cells

Testis (Reproductive System) fully expand to see all 4 entries
Leydig Cells Testis Interstitium
seminal vesicle ; glandular cells

Colon (Gastrointestinal Tract) fully expand to see all 4 entries
colon ; peripheral nerve/ganglion

Brain (Nervous System) fully expand to see all 4 entries
Cerebral Cortex

See YWHAB Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for YWHAB

SOURCE GeneReport for Unigene cluster: Hs.643544

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(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD , ⁵MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or ⁶Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
About This Section

This gene was present in the common ancestor of animals.

Orthologs for YWHAB gene from 7/16 species (see all 16) About this table

Organism	Taxonomic classification	Gene	Description	Human Similarity	Orthology Type	Details
mouse (Mus musculus)	Mammalia	Ywhab^{1 , 5}	tyrosine 3-monooxygenase/tryptophan 5-monooxygenase more^{1, 5}	90.65(n)¹ 98.78(a)¹		2 (84.59 cM)⁵ 54401¹ NM_018753.6¹ NP_061223.2¹ 163994960⁵
chicken (Gallus gallus)	Aves	YWHAB¹	tyrosine 3-monooxygenase/tryptophan 5-monooxygenase more	84.7(n) 97.95(a)		419190 NM_001006289.1 NP_001006289.1
lizard (Anolis carolinensis)	Reptilia	YWHAB⁶	Uncharacterized protein	97(a)	1 ↔ 1	4(143599734-143603777)
African clawed frog (Xenopus laevis)	Amphibia	M86928.1²	--	79.86(n)		M86928.1
zebrafish (Danio rerio)	Actinopterygii	CA473362.1²	--	81.66(n)		323055 CA473362.1
fruit fly (Drosophila melanogaster)	Insecta	14-3-3&zgr;³	RAS protein signal transduction diacylglycerol-activated/phospholipid more	79(a)		--
worm (Caenorhabditis elegans)	Secernentea	ftt-2⁶ par-5⁶	14-3-3-like protein 1	78(a) 75(a)	many ↔ many many ↔ many	X(11603707-11605421) IV(11820505-11821924)

ENSEMBL Gene Tree for YWHAB (if available)
TreeFam Gene Tree for YWHAB (if available)

(Paralogs according to ¹HomoloGene,
²Ensembl, and ³SIMAP, Pseudogenes according to ⁴Pseudogene.org Build 68)
About This Section

Paralogs for YWHAB gene

YWHAH² YWHAE² YWHAQ² YWHAG² SFN² YWHAZ²

9 SIMAP similar genes for YWHAB using alignment to 4 protein entries: 1433B_HUMAN (see all proteins):

YWHAZ YWHAQ 14-3-3 protein YWHAH SFN YWHAG

YWHAE/FAM22B fusion YWHAE/FAM22A fusion YWHAE

YWHAB for paralogs About GeneDecksing

2 Pseudogenes.org Pseudogenes for YWHAB
PGOHUM00000242182 PGOHUM00000236462

(SNPs/Variants according to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, ⁴UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section

SNP ID	Valid	Clinical significance	Chr 20 pos	Sequence	#	AA Chg	Type	More	#	Allele freq	Pop	Total sample	More
Genomic Data					Transcription Related Data				Allele Frequencies
				--	--	--		--	--
VAR_064762⁴		--	--	see VAR_064762	2	V I	mis⁴		0	--	--	--	--
rs151064529^1,2	C	--	43512385(+)	`ATGAC-/AGATAAC`	2	--	us2k¹		0	--	--	--	--
rs191350643^1,2		--	43512426(+)	`AAGGGA/TCCCTG`	2	--	us2k¹		0	--	--	--	--
rs183117638^1,2		--	43512526(+)	`TTACCA/TGACAA`	2	--	us2k¹		0	--	--	--	--
rs187408801^1,2		--	43512558(+)	`TCACAC/TAGAAA`	2	--	us2k¹		0	--	--	--	--
rs139216004^1,2	C	--	43512560(+)	`ACACAC/GAAACT`	2	--	us2k¹		0	--	--	--	--
rs192553646^1,2		--	43512679(+)	`GGGGAA/GAAATA`	2	--	us2k¹		0	--	--	--	--
rs183224684^1,2		--	43512692(+)	`AGCTAA/CAGGAT`	2	--	us2k¹		0	--	--	--	--
rs11480448^1,2	C	--	43512853(+)	`TGAGAG/-CCAAA`	2	--	us2k¹		1		CSA	2
rs76456831^1,2	C	--	43512854(+)	`TGAGAG/CCAAAT`	2	--	us2k¹		1		WA	2

HapMap Linkage Disequilibrium report for YWHAB (43514317 - 43537173 bp)

Structural Variations
Database of Genomic Variants (DGV) 1 variation for YWHAB: About this table

Variant ID	Type	Subtype	PubMed ID
nsv518547	CNV	Gain	19592680

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(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
About This Section

OMIM gene information: 601289 OMIM disorders: --

20/21 diseases for YWHAB (see all 21): About MalaCards

tuberous sclerosis complex tuberous sclerosis multiple system atrophy williams-beuren syndrome

lipodystrophy bladder carcinoma insulin resistance systemic lupus erythematosus

lupus erythematosus renal cell carcinoma glioblastoma hepatitis c

schizophrenia gastric cancer alzheimer's disease hepatocellular carcinoma

colorectal cancer hepatitis prostate cancer prostatitis

YWHAB for disorders About GeneDecksing

Congresses - knowledge worth sharing:
Alzheimer's & Parkinson's Diseases Congress (ADPD) 18 - 22 March 2015
Genetic Association Database (GAD): YWHAB
Human Genome Epidemiology (HuGE) Navigator: YWHAB (1 document)

Export disorders for YWHAB gene to outside databases

(in PubMed. Associations of this gene to articles via ¹Entrez Gene, ²UniProtKB/Swiss-Prot, ³HGNC, ⁴GAD, ⁵PharmGKB, ⁶HMDB, ⁷DrugBank, ⁸UniProtKB/TrEMBL, ⁹ Novoseek, and/or ¹⁰fRNAdb)
About This Section

PubMed articles for YWHAB gene, integrated from 9 sources (see all 246):
(articles sorted by number of sources associating them with YWHAB)

Utopia: connect your pdf to the dynamic
world of online information

Phosphorylation-dependent binding of 14-3-3 terminates signalling by the Gab2 docking protein. (PubMed id 19172738)^{1, 2} Brummer T.... Daly R.J. (2008)
Examination of association to autism of common genetic variationin genes related to dopamine. (PubMed id 19360691)^{1, 4} Anderson B.M....Haines J.L. (2008)
Inactivation of YAP oncoprotein by the Hippo pathway is involved in cell contact inhibition and tissue growth control. (PubMed id 17974916)^{1, 2} Zhao B.... Guan K.L. (2007)
Homodimerization of Ror2 tyrosine kinase receptor induces 14-3- 3(beta) phosphorylation and promotes osteoblast differentiation and bone formation. (PubMed id 17717073)^{1, 2} Liu Y.... Billiard J. (2007)
Proteomic and bioinformatic characterization of the biogenesis and function of melanosomes. (PubMed id 17081065)^{1, 2} Chi A....Hunt D.F. (2006)
A pathway of neuregulin-induced activation of cofilin-phosphatase Slingshot and cofilin in lamellipodia. (PubMed id 15159416)^{1, 2} Nagata-Ohashi K.... Mizuno K. (2004)
The CREB coactivator TORC2 functions as a calcium- and cAMP-sensitive coincidence detector. (PubMed id 15454081)^{1, 2} Screaton R.A.... Montminy M. (2004)
Association of a four-amino acid residue insertion polymorphism of the HS1 gene with systemic lupus erythematosus: molecular and functional analysis. (PubMed id 15022330)^{1, 4} Otsuka J....Harada M. (2004)
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)^{1, 2} Gerhard D.S....Malek J. (2004)
Exploring proteomes and analyzing protein processing by mass spectrometric identification of sorted N-terminal peptides. (PubMed id 12665801)^{1, 2} Gevaert K.... Vandekerckhove J. (2003)

(in PubMed, OMIM, and NCBI Bookshelf)
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		AND	OR
Aliases
Free Text

Query String		PubMed OMIM NCBI Bookshelf
	(Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
About This Section

Entrez Gene: 7529	HGNC: 12849	AceView: YWHAB	Ensembl:ENSG00000166913	euGenes: HUgn7529
ECgene: YWHAB	Kegg: 7529	H-InvDB: YWHAB

(According to HUGE)
About This Section

(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section

Name	Description
PharmGKB entry for YWHAB	Pharmacogenomics, SNPs, Pathways

Intellectual Property for YWHAB gene
(Patent information from GeneIP, Licensable technologies from WIS Yeda, Salk, Tufts, IP news from LifeMap Sciences, Inc.)

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Patent Information for YWHAB gene:
Search GeneIP for patents involving YWHAB

GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search

(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Sirion Biotech, Cell lines from GenScript, and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences, In Situ Hybridization Assays from
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