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YWHAB Gene

protein-coding GIFtS: 70
GCID: GC20P043515

Tyrosine 3-Monooxygenase/Tryptophan 5-Monooxygenase Activation...

(Previous names: tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation...)
(Previous symbol: YWHAA)

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disease database

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc, ⁷Ensembl, ⁸DME, ⁹miRBase, ¹⁰fRNAdb, ¹²H-InvDB, ¹³NCBI, ¹⁴NONCODE, and/or ¹⁵RNAdb)
About This Section

Aliases
Tyrosine 3-Monooxygenase/Tryptophan 5-Monooxygenase Activation Protein, Beta¹ ²		14-3-3 Beta¹
YWHAA¹ ²		14-3-3 Protein Beta/Alpha²
Tyrosine 3-Monooxygenase/Tryptophan 5-Monooxygenase Activation Protein, Alpha Polypeptide¹ ²		GW128²
Tyrosine 3-Monooxygenase/Tryptophan 5-Monooxygenase Activation Protein, Beta Polypeptide¹ ²		HEL-S-1²
14-3-3 Alpha¹ ²		HS1²
Protein 1054² ³		Brain Protein 14-3-3, Beta Isoform²
Protein Kinase C Inhibitor Protein 1² ³		Epididymis Secretory Protein Li 1²
KCIP-1² ³		Protein Kinase C Inhibitor Protein-1²

External Ids:	HGNC: 12849¹	Entrez Gene: 7529²	Ensembl: ENSG00000166913⁷	OMIM: 601289⁵	UniProtKB: P31946³

Export aliases for YWHAB gene to outside databases

Previous GC identifers: GC20P043242 GC20P043202 GC20P044152 GC20P044199 GC20P042947 GC20P040256

(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for YWHAB Gene:

This gene encodes a protein belonging to the 14-3-3 family of proteins, members of which mediate signal

transduction by binding to phosphoserine-containing proteins. This highly conserved protein family is found in

both plants and mammals. The encoded protein has been shown to interact with RAF1 and CDC25 phosphatases,

suggesting that it may play a role in linking mitogenic signaling and the cell cycle machinery. Two transcript

variants, which encode the same protein, have been identified for this gene. (provided by RefSeq, Jul 2008)

GeneCards Summary for YWHAB Gene:

YWHAB (tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, beta) is a protein-coding gene. GO annotations related to this gene include protein C-terminus binding and enzyme binding. An important paralog of this gene is YWHAH.

UniProtKB/Swiss-Prot: 1433B_HUMAN, P31946

Function: Adapter protein implicated in the regulation of a large spectrum of both general and specialized

signaling pathways. Binds to a large number of partners, usually by recognition of a phosphoserine or

phosphothreonine motif. Binding generally results in the modulation of the activity of the binding partner.

Negative regulator of osteogenesis. Blocks the nuclear translocation of the phosphorylated form (by AKT1) of

SRPK2 and antagonizes its stimulatory effect on cyclin D1 expression resulting in blockage of neuronal apoptosis

elicited by SRPK2

summary for YWHAB Gene:

14.3.3 proteins are a group of highly conserved proteins that are involved in many vital cellular processes

such as metabolism, protein trafficking, signal transduction, apoptosis and cell cycle regulation. 14.3.3

proteins are phospho-serine/phospho-threonine binding proteins that have a diverse array of partners

including transcription factors, biosynthetic enzymes, cytoskeletal proteins, signalling molecules,

apoptosis factors and tumour suppressors. The 14.3.3 family consists of 7 isoforms; beta, gamma, epsilon,

sigma, zeta, tau and eta. 14.3.3 proteins are ubiquitously expressed and self assemble into homo- and

heterodimers, with the exception of 14.3.3sigma, which exclusively forms homodimers and is found in cells of

epithelial origin only. Each monomer contains an independent ligand-binding site, thus the 14.3.3 dimer can

interact with two target proteins simultaneously. 14.3.3 proteins are highly rigid structures and ligand

binding can induce conformational changes that alter the stability and/or catalytic activity of the ligand.

Furthermore, 14.3.3 protein binding can physically occlude sequence-specific or structural motifs on the

target that prevent molecular interactions and/or modulate the accessibility of a target protein to

modifying enzymes such as kinases, phosphatases and proteases. In addition, 14.3.3 proteins can act as a

scaffold molecule to anchor target proteins within close proximity of one another. 14.3.3 proteins represent

an integration point for proliferative, survival, apoptotic and stress signalling pathways. Members of the

14.3.3 protein family enhance the activity of many proteins with proliferative and/or survival functions,

such as Raf kinases, and antagonise the activity of proteins that promote cell death and senescence, such as

Bad, Bim and Bax. In contrast, 14.3.3sigma acts as a tumour suppressor and its expression is upregulated

coordinately with p53 and BRAC1. This isoform sequesters cdk1-cyclin B complexes in the cytoplasm, and thus

delays cell cycle progression. 14.3.3sigma is also a crucial regulator of translation during mitosis.

Because many 14.3.3 interactions are phosphorylation dependent, 14.3.3 proteins have been integrated into

the core regulatory pathways that are crucial for normal growth and development. 14.3.3 proteins are

directly involved in cellular processes such as cytokinesis, cell-contact inhibition, anchorage-independent

growth and cell adhesion, and it is these pathways that often become dysregulated in disease states such as

cancer.

Gene Wiki entry for YWHAB Gene

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
About This Section

RefSeq DNA sequence at NCBI GenBank:

NC_000020.10 NC_018931.2 NT_011362.11

Regulatory elements:

Regulatory transcription factor binding sites in the YWHAB gene promoter:
MEF-2 E47 CREB MEF-2A POU2F1 FOXJ2 (long isoform) POU2F1a Hand1 FOXJ2 aMEF-2
Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: YWHAB promoter sequence

Search Chromatin IP Primers for YWHAB

Epigenetics:

DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat YWHAB

Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 20q13.1 Ensembl cytogenetic band: 20q13.12 HGNC cytogenetic band: 20q13.1

YWHAB Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
YWHAB gene location

GeneLoc information about chromosome 20 GeneLoc Exon Structure

GeneLoc location for GC20P043515: view genomic region (about GC identifiers)

Start:	43,514,317 bp from pter	End:	43,537,173 bp from pter
Size:	22,857 bases	Orientation:	plus strand

(According to ¹UniProtKB, HORDE, ²neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., eBioscience, antibodies-online, and/or GeneTex,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., eBioscience, and/or antibodies-online, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, Cloud-Clone Corp, antibodies-online, and/or others.)
About This Section

UniProtKB/Swiss-Prot: 1433B_HUMAN, P31946 (See protein sequence)

Recommended Name: 14-3-3 protein beta/alpha

Size: 246 amino acids; 28082 Da

Subunit: Homodimer. Interacts with SAMSN1 and PRKCE (By similarity). Interacts with SSH1 and TORC2/CRTC2.

Interacts with ABL1; the interaction results in cytoplasmic location of ABL1 and inhibition of cABL-mediated

apoptosis. Interacts with ROR2 (dimer); the interaction results in phosphorylation of YWHAB on tyrosine residues.

Interacts with GAB2 and YAP1 (phosphorylated form). Interacts with the phosphorylated (by AKT1) form of SRPK2.

Interacts with PKA-phosphorylated AANAT

3 PDB 3D structures from and Proteopedia for YWHAB:

2BQ0 (3D)

2C23 (3D)

4DNK (3D)

Secondary accessions: A8K9K2 E1P616

Alternative initiation: 2 isoforms: P31946-1 P31946-2 (Contains a N-acetylmethionine at position 1 (By similarity))

Explore the universe of human proteins at neXtProt for YWHAB: NX_P31946

Explore proteomics data for YWHAB at MOPED

Post-translational modifications:

The alpha, brain-specific form differs from the beta form in being phosphorylated (By similarity). Phosphorylated

on Ser-60 by protein kinase C delta type catalytic subunit in a sphingosine-dependent fashion (By similarity)¹

Isoform Short contains a N-acetylmethionine at position 1 (By similarity)¹

Ubiquitination² at Lys11, Lys13, Lys51, Lys70, Lys117, Lys122, Lys124, Lys140, Lys160

Modification sites at PhosphoSitePlus

See YWHAB Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

REFSEQ proteins (2 alternative transcripts):

NP_003395.1 NP_647539.1

ENSEMBL proteins:

ENSP00000300161 ENSP00000361930 ENSP00000394729 ENSP00000394558

Reactome Protein details: P31946

YWHAB Human Recombinant Protein Products:

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	Browse Proteins at Cloud-Clone Corp.
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	Search GeneTex for Proteins for YWHAB
	antibodies-online proteins for YWHAB (6 products)
	antibodies-online peptides for YWHAB

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	antibodies-online antibodies for YWHAB (97 products)

YWHAB Assay Products:

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	antibodies-online kits for YWHAB (7 products)

(According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GenesLikeMe)
About This Section

3 InterPro protein domains:

IPR023409 14-3-3_CS

IPR023410 14-3-3_domain

IPR000308 14-3-3

Graphical View of Domain Structure for InterPro Entry P31946

ProtoNet protein and cluster: P31946

1 Blocks protein domain: IPB000308 14-3-3 protein

UniProtKB/Swiss-Prot: 1433B_HUMAN, P31946

Similarity: Belongs to the 14-3-3 family

Find genes that share domains with YWHAB About GenesLikeMe

(According to ¹UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or ²DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, genOway,
transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene, Sets of similar genes according to GenesLikeMe)
About This Section

Molecular Function:

UniProtKB/Swiss-Prot Summary: 1433B_HUMAN, P31946

Function: Adapter protein implicated in the regulation of a large spectrum of both general and specialized

signaling pathways. Binds to a large number of partners, usually by recognition of a phosphoserine or

phosphothreonine motif. Binding generally results in the modulation of the activity of the binding partner.

Negative regulator of osteogenesis. Blocks the nuclear translocation of the phosphorylated form (by AKT1) of

SRPK2 and antagonizes its stimulatory effect on cyclin D1 expression resulting in blockage of neuronal apoptosis

elicited by SRPK2

Genatlas biochemistry entry for YWHAB:

tyrosine 3-monooxygenase/trytophan 5 monooxygenase activation protein,14-3-3 beta protein,including the

phosphorylated form YWHAA (alpha),multifunctional regulator involved in cell-cyle control (checkpoint) and signal

transduction,inhibitor of apoptosis through inhibiting the activation of p38 MAP kinase

Gene Ontology (GO): Selected molecular function terms (see all 9): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0003714	transcription corepressor activity	IEA	--
GO:0005515	protein binding	IPI	10713667
GO:0008022	protein C-terminus binding	IEA	--
GO:0019899	enzyme binding	IPI	17255105
GO:0019904	protein domain specific binding	IPI	11984006

Find genes that share ontologies with YWHAB About GenesLikeMe

Animal Models:

genOway: Develop your customized and physiologically relevant rodent model for YWHAB

miRNA Products:		miRTarBase miRNAs that target YWHAB: hsa-mir-877-3p (MIRT037014), hsa-mir-1301-3p (MIRT035990), hsa-mir-378a-5p (MIRT044012), hsa-mir-221-3p (MIRT046917)

		Block miRNA regulation of human, mouse, rat YWHAB using miScript Target Protectors
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		hsa-miR-124* hsa-miR-4291 hsa-miR-429 hsa-miR-128 hsa-miR-759 hsa-miR-183* hsa-miR-1276 hsa-miR-200b

		SwitchGear 3'UTR luciferase reporter plasmid: YWHAB 3' UTR sequence

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Gene Editing
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In Situ Assay
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Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for YWHAB

(According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene, Sets of similar genes according to GenesLikeMe)
About This Section

Subcellular locations from UniProtKB/Swiss-Prot

1433B_HUMAN, P31946: Cytoplasm. Melanosome. Note=Identified by mass spectrometry in melanosome fractions from

stage I to stage IV

Subcellular locations from COMPARTMENTS:

Compartment	Confidence
cytosol	4
cytoskeleton	3
nucleus	3
golgi apparatus	1

About this image

Gene Ontology (GO): Selected cellular component terms (see all 9): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005634	nucleus	--	--
GO:0005737	cytoplasm	IDA	--
GO:0005829	cytosol	TAS	--
GO:0017053	transcriptional repressor complex	IEA	--
GO:0030659	cytoplasmic vesicle membrane	TAS	--

Find genes that share ontologies with YWHAB About GenesLikeMe

(SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GenesLikeMe, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to ¹UniProtKB, ²MINT, ³I2D, and/or ⁴STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene, Sets of similar genes according to GenesLikeMe)
About This Section

SuperPaths for YWHAB About (see all 71)

See pathways by source

Powered
by

SuperPath

Selected contained pathways About (see all per SuperPath)

Cell cycle

Cell cycle

0.59

Cell cycle

0.59

Cell cycle Role of 14-3-3 proteins in cell cycle regulation

14-3-3 and Cell Cycle Regulation

0.45

Cell cycle Role of 14-3-3 proteins in cell cycle regulation

0.45

Development Dopamine D2 receptor transactivation of EGFR

Apoptosis and survival BAD phosphorylation

0.41

BAD Phosphorylation

0.40

Signaling by FGFR

Signaling by FGFR	0.91	DAP12 interactions	0.89
Signaling by FGFR in disease	0.91	Signaling by PDGF	0.87
Downstream signaling of activated FGFR	0.91	Signaling by EGFR	0.83
Downstream signal transduction	0.90	Signaling by EGFR in Cancer	0.82

Insulin receptor signalling cascade

Insulin receptor signalling cascade	0.94	Signaling by Insulin receptor	0.80
IRS-related events	0.94	SHC-related events	0.00
Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R)	0.92	SHC-mediated signalling	0.00
IRS-mediated signalling	0.92	SOS-mediated signalling	0.00

Find genes that share SuperPaths with YWHAB About GenesLikeMe

Pathways by source See SuperPaths
Show all pathways

1 R&D Systems Pathway for YWHAB

Apoptosis Signaling Pathways

Selected Downloadable PowerPoint Slides of GeneGlobe Pathway Central Maps for YWHAB (see all 18)

	14-3-3 Induced Apoptosis
	DHA Signaling
	PKA Signaling
	ERK5 Signaling
	BDNF Pathway

4 Cell Signaling Technology (CST) Pathways for YWHAB

	MAP Kinase Signaling
	Apoptosis and Autophagy
	Cell Cycle / Checkpoint Control
	Tyrosine Kinases / Adaptors

2 Tocris Bioscience Pathways for YWHAB

	Insulin Pathway
	Apoptosis Pathway

Selected GeneGo (Thomson Reuters) Pathways for YWHAB (see all 7)

	Apoptosis and survival BAD phosphorylation
	Development Role of HDAC and calcium/calmodulin-dependent kinase (CaMK) in control of skeletal myogenesis
	Development IGF-1 receptor signaling
	Cytoskeleton remodeling Role of PKA in cytoskeleton reorganisation
	Immune response Function of MEF2 in T lymphocytes

Selected BioSystems Pathways for YWHAB (see all 20)

	Myometrial Relaxation and Contraction Pathways
	Cell cycle
	EGFR1 Signaling Pathway
	SIDS Susceptibility Pathways
	Calcium Regulation in the Cardiac Cell

Selected Reactome Pathways for YWHAB (see all 11)

	MEK activation
	Frs2-mediated activation
	Signaling by Hippo
	Butyrate Response Factor 1 (BRF1) destabilizes mRNA
	Activation of BAD and translocation to mitochondria

Selected Kegg Pathways (Kegg details for YWHAB) (see all 7):

	Cell cycle
	Oocyte meiosis
	PI3K-Akt signaling pathway
	Hippo signaling pathway
	Hepatitis B

Custom Pathway & Disease-focused RT² Profiler PCR Arrays for YWHAB
Interactions:

GeneGlobe Interaction Network for YWHAB

STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

Selected Interacting proteins for YWHAB (P31946^{1, 2, 3} ENSP00000300161⁴) via UniProtKB, MINT, STRING, and/or I2D (see all 1063)

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
TSC2	P49815¹^,²^,³, ENSP00000219476⁴	EBI-359815,EBI-396587 MINT-8009815 MINT-8006263 MINT-15978 MINT-50944 MINT-8006321 MINT-15979 MINT-17162 MINT-15977 I2D: score=6 STRING: ENSP00000219476
ENSG00000237724	P08107²^,³, ENSP00000406359⁴	MINT-50346 I2D: score=4 STRING: ENSP00000406359
HSPA1A	P08107²^,³, ENSP00000364802⁴	MINT-50346 I2D: score=4 STRING: ENSP00000364802
ENSG00000212866	P08107²^,³	MINT-50346 I2D: score=4
ENSG00000215328	P08107²^,³	MINT-50346 I2D: score=4

About this table

Gene Ontology (GO): Selected biological process terms (see all 25): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0000165	MAPK cascade	TAS	--
GO:0000186	activation of MAPKK activity	TAS	--
GO:0006605	protein targeting	IEA	--
GO:0006915	apoptotic process	TAS	--
GO:0007173	epidermal growth factor receptor signaling pathway	TAS	--

Find genes that share ontologies with YWHAB About GenesLikeMe

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, Sets of similar genes according to GenesLikeMe)
About This Section

Browse Small Molecules at EMD Millipore

Browse drugs & compounds from Enzo Life Sciences

Browse compounds at ApexBio

Compounds for YWHAB available from Tocris Bioscience About this table

Compound	Action	CAS #
Difopein	High affinity inhibitor of 14.3.3 proteins; induces apoptosis	[396834-58-5]
R18	Inhibitor of 14.3.3 proteins; induces apoptosis	[211364-78-2]

2 HMDB Compounds for YWHAB About this table

Compound	Synonyms	CAS #	PubMed Ids
Sepiapterin	L-sepiapterin (see all 8)	17094-01-8	--
Zolpidem	Ambien (see all 7)	82626-48-0	--

1 Novoseek inferred chemical compound relationship for YWHAB gene About this table

Compound	-log (P-Val)	Hits	PubMed IDs for Articles with Shared Sentences (# sentences)
serine	28.2	1	16469478 (1)

Find genes that share compounds with YWHAB About GenesLikeMe

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
About This Section

REFSEQ mRNAs for YWHAB gene (2 alternative transcripts):

NM_003404.4 NM_139323.3

Unigene Cluster for YWHAB:

Tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, beta polypeptide

Hs.643544 [show with all ESTs]

Unigene Representative Sequence: AB209759

7 Ensembl transcripts including schematic representations, and UCSC links where relevant:

ENST00000353703(uc002xmu.3) ENST00000479421 ENST00000372839(uc002xmt.3)

ENST00000428262 ENST00000445830 ENST00000477896 ENST00000479758

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Additional mRNA sequence:

AB209759.1 AB451260.1 AB451386.1 AF064847.1 AF107406.1 AK292717.1 AL834170.1 BC001359.2

BC010352.1 X57346.1

Selected DOTS entries (see all 49):

DT.75122682 DT.100883284 DT.87077844 DT.100883297 DT.92325870 DT.100883281 DT.100883300 DT.100059833

DT.92007444 DT.95256702 DT.120826031 DT.100883289 DT.95118446 DT.95151426 DT.100883292 DT.120826074

DT.100883274 DT.100059820 DT.95151410 DT.120826094 DT.91772166 DT.100883277 DT.95151421 DT.100883266

Selected AceView cDNA sequences (see all 1367):

AW472766 BQ183152 BU540599 AA167429 CD743146 AA459239 BM843443 BM758152

CB119741 F05953 H39869 AA854663 N33792 BM754925 BM830874 BF718694

AW467473 CB140640 T33559 BQ679676 AA614855 BQ893661 T48550 BM709010

GeneLoc Exon Structure

Selected Alternative Splicing Database (ASD) splice patterns (SP) for YWHAB (see all 10) About this scheme

ExUns:	1a	·	1b	^	2	^	3a	·	3b	^	4a	·	4b	·	4c	·	4d	^	5a	·	5b	·	5c	^	6a	·	6b	^	7a	·	7b	^	8	^	9a	·	9b	·	9c
SP1:					-		-										-		-		-		-
SP2:					-		-		-								-		-		-		-
SP3:
SP4:																	-
SP5:							-

ECgene alternative splicing isoforms for YWHAB

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GenesLikeMe, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE ¹MOPED, ²PaxDb, and ³MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section

YWHAB expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS <intensity>^2/3
CGAP TAG: CAGTTACTTA

About this image

YWHAB expression in embryonic tissues and stem cells About this table

Data from LifeMap, the Embryonic Development and Stem Cells Database
selected tissues (see all 19) fully expand


Brain (Nervous System) fully expand to see all 4 entries
Cerebral Cortex

Ovary (Reproductive System) fully expand to see all 2 entries
Ovarian Mesenchymal Stroma Cells Ovary Interstitium
Oviduct

Testis (Reproductive System)
Leydig Cells Testis Interstitium

Trophoblast (Extraembryonic Tissues)
Trophoblast Cells Trophoblast

Bone (Muscoskeletal System)
Bone Marrow

YWHAB Protein expression data from MOPED¹, PaxDb² and MaxQB³:

About this image

YWHAB Protein Expression

SOURCE GeneReport for Unigene cluster: Hs.643544

Custom PCR Arrays for YWHAB

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(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD , ⁵MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or ⁶Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
About This Section

This gene was present in the common ancestor of animals.

Orthologs for YWHAB gene from Selected species (see all 16) About this table

Organism	Taxonomic classification	Gene	Description	Human Similarity	Orthology Type	Details
mouse (Mus musculus)	Mammalia	Ywhab^{1 , 5}	tyrosine 3-monooxygenase/tryptophan 5-monooxygenase more^{1, 5}	90.65(n)¹ 98.78(a)¹		2 (84.59 cM)⁵ 54401¹ NM_018753.6¹ NP_061223.2¹ 163994960⁵
chicken (Gallus gallus)	Aves	YWHAB¹	tyrosine 3-monooxygenase/tryptophan 5-monooxygenase more	84.7(n) 97.95(a)		419190 NM_001006289.1 NP_001006289.1
lizard (Anolis carolinensis)	Reptilia	YWHAB⁶	tyrosine 3-monooxygenase/tryptophan 5-monooxygenas...	97(a)	1 ↔ 1	4(143599734-143603777)
African clawed frog (Xenopus laevis)	Amphibia	M86928.1²	--	79.86(n)		M86928.1
zebrafish (Danio rerio)	Actinopterygii	CA473362.1²	--	81.66(n)		323055 CA473362.1
fruit fly (Drosophila melanogaster)	Insecta	14-3-3&zgr;³	RAS protein signal transduction diacylglycerol-activated/phospholipid more	79(a)		--
worm (Caenorhabditis elegans)	Secernentea	ftt-2⁶ par-5⁶	Protein PAR-5 (par-5) mRNA, complete cds	77(a) 75(a)	many ↔ many many ↔ many	X(11603707-11605412) WBGene00001502 IV(11820505-11821917) WBGene00003920

ENSEMBL Gene Tree for YWHAB (if available)
TreeFam Gene Tree for YWHAB (if available)

(Paralogs according to ¹HomoloGene,
²Ensembl, and ³SIMAP, Pseudogenes according to ⁴Pseudogene.org Build 68,Sets of similar genes according to GenesLikeMe)
About This Section

Paralogs for YWHAB gene

YWHAH² YWHAE² YWHAQ² YWHAG² SFN² YWHAZ²

9 SIMAP similar genes for YWHAB using alignment to 4 protein entries: 1433B_HUMAN (see all proteins):

YWHAZ YWHAQ 14-3-3 protein YWHAH SFN YWHAG

YWHAE/FAM22B fusion YWHAE/FAM22A fusion YWHAE

Find genes that share paralogs with YWHAB About GenesLikeMe

2 Pseudogenes.org Pseudogenes for YWHAB
PGOHUM00000242182 PGOHUM00000236462

(SNPs/Variants according to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, ⁴UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
About This Section

SNP ID	Valid	Clinical significance	Chr 20 pos	Sequence	#	AA Chg	Type	More	#	Allele freq	Pop	Total sample	More
Genomic Data					Transcription Related Data				Allele Frequencies
				--	--	--		--	--
rs151064529^1,2	C	--	43512385(+)	`ATGAC-/AGATAAC`	2	--	us2k¹		0	--	--	--	--
rs191350643^1,2		--	43512426(+)	`AAGGGA/TCCCTG`	2	--	us2k¹		0	--	--	--	--
rs183117638^1,2		--	43512526(+)	`TTACCA/TGACAA`	2	--	us2k¹		0	--	--	--	--
rs187408801^1,2		--	43512558(+)	`TCACAC/TAGAAA`	2	--	us2k¹		0	--	--	--	--
rs139216004^1,2	C	--	43512560(+)	`ACACAC/GAAACT`	2	--	us2k¹		0	--	--	--	--
rs192553646^1,2		--	43512679(+)	`GGGGAA/GAAATA`	2	--	us2k¹		0	--	--	--	--
rs183224684^1,2		--	43512692(+)	`AGCTAA/CAGGAT`	2	--	us2k¹		0	--	--	--	--
rs11480448^1,2	C	--	43512853(+)	`TGAGAG/-CCAAA`	2	--	us2k¹		1		CSA	2
rs76456831^1,2	C	--	43512854(+)	`TGAGAG/CCAAAT`	2	--	us2k¹		1		WA	2
rs192491214^1,2		--	43512976(+)	`CCACCG/TGCCTT`	2	--	us2k¹		0	--	--	--	--

HapMap Linkage Disequilibrium report for YWHAB (43514317 - 43537173 bp)

Structural Variations
Database of Genomic Variants (DGV) 1 variation for YWHAB: About this table

Variant ID	Type	Subtype	PubMed ID
nsv518547	CNV	Gain	19592680

Site Specific Mutation Identification with PCR Assays

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(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB, Sets of similar genes according to GenesLikeMe)
About This Section

OMIM gene information: 601289 OMIM disorders: --

Find genes that share disorders with YWHAB About GenesLikeMe

Genetic Association Database (GAD): YWHAB
Human Genome Epidemiology (HuGE) Navigator: YWHAB (1 document)

Export disorders for YWHAB gene to outside databases

(in PubMed. Associations of this gene to articles via ¹Entrez Gene, ²UniProtKB/Swiss-Prot, ³HGNC, ⁴GAD, ⁵PharmGKB, ⁶HMDB, ⁷DrugBank, ⁸UniProtKB/TrEMBL, ⁹ Novoseek, and/or ¹⁰fRNAdb)
About This Section

PubMed articles for YWHAB gene, integrated from 10 sources (see all 252):
(articles sorted by number of sources associating them with YWHAB)

Utopia: connect your pdf to the dynamic
world of online information

Phosphorylation-dependent binding of 14-3-3 terminates signalling by the Gab2 docking protein. (PubMed id 19172738)^{1, 2} Brummer T.... Daly R.J. (EMBO J. 2008)
Examination of association to autism of common genetic variationin genes related to dopamine. (PubMed id 19360691)^{1, 4} Anderson B.M....Haines J.L. (Autism Res 2008)
Inactivation of YAP oncoprotein by the Hippo pathway is involved in cell contact inhibition and tissue growth control. (PubMed id 17974916)^{1, 2} Zhao B.... Guan K.L. (Genes Dev. 2007)
Homodimerization of Ror2 tyrosine kinase receptor induces 14-3- 3(beta) phosphorylation and promotes osteoblast differentiation and bone formation. (PubMed id 17717073)^{1, 2} Liu Y.... Billiard J. (Mol. Endocrinol. 2007)
Proteomic and bioinformatic characterization of the biogenesis and function of melanosomes. (PubMed id 17081065)^{1, 2} Chi A....Hunt D.F. (J. Proteome Res. 2006)
A pathway of neuregulin-induced activation of cofilin-phosphatase Slingshot and cofilin in lamellipodia. (PubMed id 15159416)^{1, 2} Nagata-Ohashi K.... Mizuno K. (J. Cell Biol. 2004)
The CREB coactivator TORC2 functions as a calcium- and cAMP-sensitive coincidence detector. (PubMed id 15454081)^{1, 2} Screaton R.A.... Montminy M. (Cell 2004)
Association of a four-amino acid residue insertion polymorphism of the HS1 gene with systemic lupus erythematosus: molecular and functional analysis. (PubMed id 15022330)^{1, 4} Otsuka J....Harada M. (Arthritis Rheum. 2004)
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)^{1, 2} Gerhard D.S.... Malek J. (Genome Res. 2004)
Exploring proteomes and analyzing protein processing by mass spectrometric identification of sorted N-terminal peptides. (PubMed id 12665801)^{1, 2} Gevaert K.... Vandekerckhove J. (Nat. Biotechnol. 2003)

(in PubMed, OMIM, and NCBI Bookshelf)
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		AND	OR
Aliases
Free Text

Query String		PubMed OMIM NCBI Bookshelf
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(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
About This Section

Entrez Gene: 7529	HGNC: 12849	AceView: YWHAB	Ensembl:ENSG00000166913	euGenes: HUgn7529
ECgene: YWHAB	Kegg: 7529	H-InvDB: YWHAB

(According to HUGE)
About This Section

(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
About This Section

Name	Description
PharmGKB entry for YWHAB	Pharmacogenomics, SNPs, Pathways

Intellectual Property for YWHAB gene
(Patent information from GeneIP, Licensable technologies from WIS Yeda, Salk, Tufts, IP news from LifeMap Sciences, Inc.)

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Patent Information for YWHAB gene:
Search GeneIP for patents involving YWHAB

GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search

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YWHAB Gene

Tyrosine 3-Monooxygenase/Tryptophan 5-Monooxygenase Activation...

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