Set Analyses:
Advanced Search

Advanced Search

 
Search By
Section (entire)
for


 



YTHDF3 Gene

protein-coding   GIFtS: 46
GCID: GC08P064081

YTH Domain Family, Member 3

(Previous name: YTH domain family 3)
  See related disease
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

TryGeneCards Plus

Aliases
YTH Domain Family, Member 31 2
YTH Domain Family 31
YTH Domain Family Protein 32
YTH Domain-Containing Family Protein 32

External Ids:    HGNC: 264651   Entrez Gene: 2539432   Ensembl: ENSG000001857287   UniProtKB: Q7Z7393   

Export aliases for YTHDF3 gene to outside databases

Previous GC identifers: GC08P064132 GC08P064243 GC08P059569


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

TryGeneCards Plus

Entrez Gene summary for YTHDF3 Gene:
This gene encodes a member of the YTH (YT521-B homology) domain protein family. The YTH domain is common in
eukaryotes, is often found in the middle of the protein sequence, and may function in binding to RNA. Alternative
splicing results in multiple transcript variants. (provided by RefSeq, Apr 2013)

GeneCards Summary for YTHDF3 Gene:
YTHDF3 (YTH domain family, member 3) is a protein-coding gene. Diseases associated with YTHDF3 include multiple sclerosis. An important paralog of this gene is YTHDF2.

UniProtKB/Swiss-Prot: YTHD3_HUMAN, Q7Z739
Function: Specifically recognizes and binds N6-methyladenosine (m6A)-containing RNAs. M6A is a modification
present at internal sites of mRNAs and some non-coding RNAs and plays a role in the efficiency of mRNA splicing,
processing and stability

Gene Wiki entry for YTHDF3 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
About This Section

TryGeneCards Plus
RefSeq DNA sequence:
NC_000008.11  NC_018919.2  NT_008183.20  
Regulatory elements:
   Regulatory transcription factor binding sites in the YTHDF3 gene promoter:
         AhR   Egr-1   FOXD3   LCR-F1   Gfi-1   Arnt   AREB6   S8   Chx10   Pax-4a   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidYTHDF3 promoter sequence
   Search Chromatin IP Primers for YTHDF3

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat YTHDF3


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 8q12.3   Ensembl cytogenetic band:  8q12.3   HGNC cytogenetic band: 8q12.3

YTHDF3 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
YTHDF3 gene location

GeneLoc information about chromosome 8         GeneLoc Exon Structure

GeneLoc location for GC08P064081:  view genomic region     (about GC identifiers)

Start:
64,081,112 bp from pter      End:
64,125,346 bp from pter
Size:
44,235 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
About This Section

TryGeneCards Plus

UniProtKB/Swiss-Prot: YTHD3_HUMAN, Q7Z739 (See protein sequence)
Recommended Name: YTH domain-containing family protein 3  
Size: 585 amino acids; 63861 Da
Secondary accessions: B3KXL4 Q63Z37 Q659A3

Explore the universe of human proteins at neXtProt for YTHDF3: NX_Q7Z739

Explore proteomics data for YTHDF3 at MOPED

Post-translational modifications: 

  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus

  • See YTHDF3 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (7 alternative transcripts): 
    NP_001264742.1  NP_001264743.1  NP_001264744.1  NP_001264745.1  NP_001264746.1  NP_001264747.1  NP_689971.4  

    ENSEMBL proteins: 
     ENSP00000473986   ENSP00000473317   ENSP00000474547   ENSP00000473496   ENSP00000473387  

    YTHDF3 Human Recombinant Protein Products:

    Browse Purified and Recombinant Proteins at EMD Millipore
    Browse R&D Systems for human recombinant proteins
    Browse recombinant and purified proteins available from Enzo Life Sciences
    Browse OriGene full length recombinant human proteins expressed in human HEK293 cells
    OriGene Protein Over-expression Lysate for YTHDF3
    OriGene Custom MassSpec
    OriGene Custom Protein Services for YTHDF3
    GenScript Custom Purified and Recombinant Proteins Services for YTHDF3
    Novus Biologicals YTHDF3 Protein
    Novus Biologicals YTHDF3 Lysate
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for YTHDF3

    YTHDF3 Antibody Products:

    Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
    Browse R&D Systems for Antibodies
    Browse OriGene Antibodies
    OriGene Custom Antibody Services for YTHDF3
    Novus Biologicals YTHDF3 Antibodies
    Abcam antibodies for YTHDF3
    Cloud-Clone Corp. Antibodies for YTHDF3
    ThermoFisher Antibodies for YTHDF3
    LSBio Antibodies in human, mouse, rat for YTHDF3

    YTHDF3 Assay Products:

    Browse Kits and Assays available from EMD Millipore
    OriGene Custom Assay Services for YTHDF3
    Browse R&D Systems for biochemical assays
    GenScript Custom Assay Services for YTHDF3
    Browse Enzo Life Sciences for kits & assays
    Cloud-Clone Corp. ELISAs for YTHDF3
    Cloud-Clone Corp. CLIAs for YTHDF3


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section

    TryGeneCards Plus
    1 InterPro protein domain:
     IPR007275 YTH_domain

    Graphical View of Domain Structure for InterPro Entry Q7Z739

    ProtoNet protein and cluster: Q7Z739

    1 Blocks protein domain: IPB007275 YT521-B-like protein

    UniProtKB/Swiss-Prot: YTHD3_HUMAN, Q7Z739
    Similarity: Contains 1 YTH domain


    YTHDF3 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
    About This Section

    TryGeneCards Plus

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: YTHD3_HUMAN, Q7Z739
    Function: Specifically recognizes and binds N6-methyladenosine (m6A)-containing RNAs. M6A is a modification
    present at internal sites of mRNAs and some non-coding RNAs and plays a role in the efficiency of mRNA splicing,
    processing and stability

         Gene Ontology (GO): 3 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005515protein binding IPI--
    GO:0044822poly(A) RNA binding IDA--
    GO:1990247N6-methyladenosine-containing RNA binding IDA--
         
    YTHDF3 for ontologies           About GeneDecksing


    Animal Models:
       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for YTHDF3
       inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for YTHDF3

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for YTHDF3
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for YTHDF3

    miRNA
    Products:
        
    Block miRNA regulation of human, mouse, rat YTHDF3 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate YTHDF3 (see all 115):
    hsa-miR-582-3p hsa-miR-579 hsa-miR-520e hsa-miR-520f hsa-miR-3152-3p hsa-miR-106a hsa-miR-30d hsa-miR-30a
    SwitchGear 3'UTR luciferase reporter plasmidYTHDF3 3' UTR sequence
    Inhib. RNA
    Products:
        
    OriGene RNAi products in human, mouse, rat for YTHDF3
    Predesigned siRNA for gene silencing in human, mouse, rat YTHDF3

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for YTHDF3

    Clone
    Products:
         
    OriGene clones in human, mouse for YTHDF3 (see all 9)
    OriGene ORF clones in mouse, rat for YTHDF3
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: YTHDF3 (NM_152758)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for YTHDF3
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat YTHDF3

    Cell Line
    Products:
         
    GenScript Custom overexpressing Cell Line Services for YTHDF3
    Browse ESI BIO Cell Lines and PureStem Progenitors for YTHDF3 
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for YTHDF3


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
    About This Section

    TryGeneCards Plus

    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    cytosol2
    nucleus2
    cytoskeleton1

    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
    About This Section

    TryGeneCards Plus



        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for YTHDF3
    Interactions:

        Search GeneGlobe Interaction Network for YTHDF3

    2 Interacting proteins for YTHDF3 (Q7Z7391, 3) via UniProtKB, MINT, STRING, and/or I2D
    InteractantInteraction Details
    GeneCardExternal ID(s)
    POT1Q9NUX53I2D: score=1 
    gagP045911EBI-2849837,EBI-6179727
    About this table

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
    About This Section

    TryGeneCards Plus
    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for YTHDF3 (YTHD3)



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
    About This Section

    TryGeneCards Plus

    REFSEQ mRNAs for YTHDF3 gene (7 alternative transcripts): 
    NM_001277813.1  NM_001277814.1  NM_001277815.1  NM_001277816.1  NM_001277817.1  NM_001277818.1  NM_152758.5  

    Unigene Cluster for YTHDF3:

    YTH domain family, member 3
    Hs.491861  [show with all ESTs]
    Unigene Representative Sequence: NM_152758
    16 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000521674(uc003xuy.3 uc010lys.3 uc003xuz.3) ENST00000522282
    ENST00000519428 ENST00000523455 ENST00000517371 ENST00000524135(uc003xva.3 uc011len.2)
    ENST00000518763 ENST00000518438 ENST00000517375 ENST00000521547 ENST00000520640
    ENST00000523056 ENST00000517303 ENST00000518373 ENST00000539294 ENST00000542911

    miRNA
    Products:
         
    Block miRNA regulation of human, mouse, rat YTHDF3 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate YTHDF3 (see all 115):
    hsa-miR-582-3p hsa-miR-579 hsa-miR-520e hsa-miR-520f hsa-miR-3152-3p hsa-miR-106a hsa-miR-30d hsa-miR-30a
    SwitchGear 3'UTR luciferase reporter plasmidYTHDF3 3' UTR sequence
    Inhib. RNA
    Products:
         
    OriGene RNAi products in human, mouse, rat for YTHDF3
    Predesigned siRNA for gene silencing in human, mouse, rat YTHDF3
    Clone
    Products:
         
    OriGene clones in human, mouse for YTHDF3 (see all 9)
    OriGene ORF clones in mouse, rat for YTHDF3
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: YTHDF3 (NM_152758)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for YTHDF3
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat YTHDF3
    Primer
    Products:
        
    OriGene qSTAR qPCR primer pairs in human, mouse for YTHDF3
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat YTHDF3
      QuantiTect SYBR Green Assays in human, mouse, rat YTHDF3
      QuantiFast Probe-based Assays in human, mouse, rat YTHDF3

    Additional mRNA sequence: 

    AK002173.1 AK056219.1 AK093081.1 AK127574.1 AK298544.1 AL050081.1 AL831816.1 AL832005.1 
    AL832335.1 AL832369.1 BC037492.1 BC052970.1 BX537996.2 

    11 DOTS entries:

    DT.102825847  DT.91749167  DT.100652083  DT.95268981  DT.100652089  DT.100666742  DT.102825850  DT.95260348 
    DT.95268980  DT.95355192  DT.91808969 

    Selected AceView cDNA sequences (see all 285):

    AA908355 AW119122 BE466725 AA284518 BQ771546 BM477044 AW169433 BM697489 
    BU735684 AI985539 BQ428174 BQ026584 BE044015 BM454875 AA418619 AI967934 
    AA706607 AI659673 BU161292 BM469418 AA633148 AA371224 AI373633 NM_152758 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    TryGeneCards Plus

    YTHDF3 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: AGAATTTGAA
    YTHDF3 Expression
    About this image

    YTHDF3 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    YTHDF3 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.491861
        Custom PCR Arrays for YTHDF3
    Primer
    Products:
    OriGene qSTAR qPCR primer pairs in human, mouse for YTHDF3
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat YTHDF3
    QuantiTect SYBR Green Assays in human, mouse, rat YTHDF3
    QuantiFast Probe-based Assays in human, mouse, rat YTHDF3
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for YTHDF3

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    TryGeneCards Plus

    This gene was present in the common ancestor of eukaryotes.

    Orthologs for YTHDF3 gene from Selected species (see all 15)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Ythdf31 , 5 YTH domain family 31, 5 96.41(n)1
    98.8(a)1
      3 (4.04 cM)5
    2290961  NM_001145919.11  NP_001139391.11 
     161831835 
    chicken
    (Gallus gallus)
    Aves YTHDF31 YTH domain family, member 3 88.45(n)
    93.83(a)
      421145  NM_001006391.1  NP_001006391.1 
    lizard
    (Anolis carolinensis)
    Reptilia YTHDF36
    YTH domain family, member 3
    93(a)
    1 ↔ 1
    4(29473027-29506059)
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia Str.89342 Transcribed sequence with weak similarity to protein more 82.49(n)    CF239562.1 
    zebrafish
    (Danio rerio)
    Actinopterygii BC045342.12   -- 78.42(n)   334191  BC045342.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta CG64226
    --
    28(a)
    1 → many
    3R(20859866-20864801)
    baker's yeast
    (Saccharomyces cerevisiae)
    Saccharomycetes --
    Putative protein of unknown function
    30(a)
    1 → many
    IV(1223474-1224394) YDR374C
    barley
    (Hordeum vulgare)
    Liliopsida Hv.55682 Transcribed sequence with weak similarity to protein more 73.48(n)    AV914848.1 


    ENSEMBL Gene Tree for YTHDF3 (if available)
    TreeFam Gene Tree for YTHDF3 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section

    TryGeneCards Plus
    Paralogs for YTHDF3 gene
    YTHDF22  YTHDF12  
    Selected SIMAP similar genes for YTHDF3 using alignment to 6 protein entries:     YTHD3_HUMAN (see all proteins) (see all similar genes):
    DKFZp451A052    DKFZp451J085    ZNF546    YTHDF2    YTHDF1    NPLOC4
    ZNF283    EDRF1    NEK4    SPECC1L-ADORA2A    ZNF738    PLEKHH2
    PLA2G6    SYPL1    CLYBL    C16orf89    TMEM44    FAM129C

    YTHDF3 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
    About This Section

    TryGeneCards Plus

    Selected SNPs for YTHDF3 (see all 848)    About this table    
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 8 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs339945941,2
    C--59587270(+) GTCAA-/GTCCAT 15 D ES fra1 int10--------
    rs78291861,2
    C--59589799(+) tatatT/Attttt 8 -- int11Minor allele frequency- A:0.50NA 2
    rs1999925731,2
    --59589799(+) TATAT-/ATTTTT 8 -- int10--------
    rs106995511,2
    C--59600118(+) CATTG-/AGTG  
            
    GTATT
    8 -- int10--------
    rs107106721,2
    C--64089234(+) CTCAGT/-TTTTT 8 -- int1 trp32Minor allele frequency- -:0.25NA CSA 4
    rs625101271,2
    --64092436(+) TGGGGC/TGGCCG 8 -- int10--------
    rs113813851,2
    C--64095514(+) TTTTT-/TCTTTT 8 -- int1 trp30--------
    rs606823711,2
    C--64096948(+) AACCT-/CTGTTAC 8 -- int10--------
    rs584198561,2
    C--64098729(+) TGTCAG/-ATCCA 15 /D /GS fra1 int12Minor allele frequency- -:0.00NA CSA 4
    rs725389821,2
    C--64098729(+) TGTCA-/GAATCC 15 D GS fra1 int10--------

    HapMap Linkage Disequilibrium report for YTHDF3 (64081112 - 64125346 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 5 variations for YTHDF3:    About this table    
    Variant IDTypeSubtypePubMed ID
    esv2677763CNV Deletion23128226
    nsv890966CNV Loss21882294
    nsv831342CNV Gain17160897
    nsv890967CNV Gain21882294
    nsv890965CNV Gain+Loss21882294

    Site Specific Mutation Identification with PCR Assays
    Search QIAGEN SeqTarget long-range PCR primers for resequencing YTHDF3
    DNA2.0 Custom Variant and Variant Library Synthesis for YTHDF3

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section

    TryGeneCards Plus
    1 disease for YTHDF3:    
    About MalaCards
    multiple sclerosis


    YTHDF3 for disorders           About GeneDecksing

    Genetic Association Database (GAD): YTHDF3

    Export disorders for YTHDF3 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    TryGeneCards Plus

    PubMed articles for YTHDF3 gene, integrated from 10 sources (see all 27):
    (articles sorted by number of sources associating them with YTHDF3)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Initial characterization of the human central proteome. (PubMed id 21269460)1, 2 Burkard T.R.... Colinge J. (BMC Syst. Biol. 2011)
    2. Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis. (PubMed id 20068231)1, 2 Olsen J.V....Mann M. (Sci. Signal. 2010)
    3. A quantitative atlas of mitotic phosphorylation. (PubMed id 18669648)1, 2 Dephoure N.... Gygi S.P. (Proc. Natl. Acad. Sci. U.S.A. 2008)
    4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    5. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (Nat. Genet. 2004)
    6. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1, 3 Strausberg R.L....Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002)
    7. N-methyladenosine-dependent regulation of messenger RNA stability. (PubMed id 24284625)2 Wang X.... He C. (Nature 2014)
    8. The HECT type ubiquitin ligase NEDL2 is degraded by anaphase-promoting complex/cyclosome (APC/C)-Cdh1, and its tight regulation maintains the metaphase to anaphase transition. (PubMed id 24163370)1 Lu L....Zhang L. (J. Biol. Chem. 2013)
    9. Replication study of 10 genes showing evidence for association with multiple sclerosis: validation of TMEM39A, IL12B and CBLB [correction of CLBL] genes. (PubMed id 22194214)1 VaradAc J....Urcelay E. (Mult. Scler. 2012)
    10. Topology of the human and mouse m6A RNA methylomes revealed by m6A- seq. (PubMed id 22575960)2 Dominissini D.... Rechavi G. (Nature 2012)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section

    TryGeneCards Plus
     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section

    TryGeneCards Plus
    Entrez Gene: 253943 HGNC: 26465 AceView: YTHDF3 Ensembl:ENSG00000185728 euGenes: HUgn253943
    ECgene: YTHDF3 H-InvDB: YTHDF3

    (According to HUGE)
    About This Section

    TryGeneCards Plus
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
    About This Section

    TryGeneCards Plus
    NameDescription
    PharmGKB entry for YTHDF3 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section

    TryGeneCards Plus
    Patent Information for YTHDF3 gene:
    Search GeneIP for patents involving YTHDF3

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript, and ESI BIO, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
    About This Section

    TryGeneCards Plus

     
     EMD Millipore genomic analysis products

      
     Browse Antibodies   Browse Cell Culture Products  
     Browse ELISAs   Browse Flow Cytometry Kits  
     Browse Primer Pairs   Browse Enzyme Activity Assays/Reagents  
     Browse ELISpot/FluoroSpot Kits/Development Modules   Browse TFB/Immunoprecipitation Assays  
     Browse Apoptosis Detection Kits/Reagents   Browse Ubiquitin Proteasome Pathway (UPP) Assay Kits/Reagents  
     Browse DNA Damage/Repair Kits/Reagents   Browse Luminex Assays  
     Browse Cell Selection/Detection Kits/Reagents   Browse Secondary Antibodies/Controls/Staining Reagents  
     Browse Recombinant/Natural Proteins   Browse Stem Cell Products  
     Browse cDNA Clones   Browse Proteome Profiler Antibody Arrays  
     Browse OriGene Antibodies   OriGene RNAi products in human, mouse, rat for YTHDF3  
     Browse OriGene qPCR primer pairs and template standards   OriGene Protein Over-expression Lysate for YTHDF3  
     OriGene Custom Mass Spec   OriGene clones in human, mouse for YTHDF3  
     OriGene qSTAR qPCR primer pairs in human, mouse for YTHDF3   Browse OriGene full length recombinant human proteins expressed in human HEK293 cells  
     OriGene ORF clones in mouse, rat for YTHDF3   OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling  
     OriGene Custom Antibody Services for YTHDF3   OriGene Custom Protein Services for YTHDF3  

     
     
     Block miRNA regulation of human, mouse, rat YTHDF3 using miScript Target Protectors SeqTarget long-range PCR primers for resequencing YTHDF3
     DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat YTHDF3 Predesigned siRNA for gene silencing in human, mouse, rat YTHDF3
     QuantiFast Probe-based Assays in human, mouse, rat YTHDF3 QuantiTect SYBR Green Assays in human, mouse, rat YTHDF3
     Custom PCR Arrays for YTHDF3 Search Chromatin IP Primers for YTHDF3
     Pre-validated RT2 qPCR Primer Assay in human, mouse, rat YTHDF3  Search GeneGlobe Interaction Network for YTHDF3
     Regulatory tfbs in YTHDF3 promoter
     GenScript Custom Purified and Recombinant Proteins Services for YTHDF3 GenScript cDNA clones with any tag delivered in your preferred vector for YTHDF3
     GenScript Custom Assay Services for YTHDF3 GenScript Custom overexpressing Cell Line Services for YTHDF3
     CloneReady with Over 120,000 Genes  Gene Synthesis: Any Gene in Any Vector
     Vector-based siRNA and miRNA, Ready for Transfection Gene Mutant Library, Variants up to 10^11
     Plasmid Preparation Custom Peptide Services
     Search for Antibodies & Assays

     Search Tocris compounds for YTHDF3 (YTHD3)
     Browse Sino Biological Proteins
     Browse Sino Biological Cell Lysates
     Browse Sino Biological cDNA Clones
     4000+ Proteins
     Search Sino Biological for antibodies, proteins & pathways
     Protein Production Services
     Transfection Reagents
     Protein A/G/L resins
     Isotyping reagents
     Search www.enzolifesciences.com for proteins, assays, substrates, inhibitors & antibodies

     Novus Tissue Slides
     YTHDF3 antibodies
     YTHDF3 proteins
     YTHDF3 lysates
     Antibodies for YTHDF3
     See all of Abcam's Antibodies, Kits and Proteins for YTHDF3
     Custom Antibody / Protein Production Service
     Bulk Purchasing
     Advantages of Rabbit Monoclonal antibodies
     Abcam protocols and scientific support
     Browse ProSpec Recombinant Proteins
     Proteins for YTHDF3
     Antibodies for YTHDF3
     ELISAs for YTHDF3
     CLIAs for YTHDF3



     Browse ESI BIO Cell Lines and PureStem Progenitors for YTHDF3
     Gene Synthesis
     Protein Engineering
     Variant Library Synthesis
     Codon Optimization
     Protein Production and Purification
     Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for YTHDF3
     SwitchGear 3'UTR luciferase reporter plasmids for YTHDF3
     SwitchGear Promoter luciferase reporter plasmids for YTHDF3
     ThermoFisher Antibodies for YTHDF3
     Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat YTHDF3
     inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for YTHDF3
     inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for YTHDF3
     LSBio Antibodies in human, mouse, rat for YTHDF3
    Customized transgenic rodents for:
     Humanization
     Biomarker expression
     Off-target effect monitoring
     Translational medicine
     Tissue-specific gene expresssion
     Time-controlled gene expresssion
     Browse compounds at ApexBio
           
    GeneCards Homepage - Last full update: 7 May 2014 - Incrementals: 9 May 2014 , 2 Jun 2014 , 26 Jun 2014 , 30 Jun 2014

    View Random Gene

    Category
    (GIFtS: )
    GIFtS Group
    The GeneCards human gene database gene index: 1 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z 


    Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

    Hot genes      Disease genes      YTHDF3 gene at Home site.
    Version: 3.12.162 20 Aug 2014
    hostname: 356977-web1.xennexinc.com index build: 126 solr: 1.4