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Aliases for YTHDF3 Gene

Aliases for YTHDF3 Gene

  • YTH N(6)-Methyladenosine RNA Binding Protein 3 2 3
  • YTH Domain Family, Member 3 2
  • YTH Domain Family 3 2

External Ids for YTHDF3 Gene

Previous GeneCards Identifiers for YTHDF3 Gene

  • GC08P064132
  • GC08P064243
  • GC08P064081
  • GC08P059569

Summaries for YTHDF3 Gene

Entrez Gene Summary for YTHDF3 Gene

  • This gene encodes a member of the YTH (YT521-B homology) domain protein family. The YTH domain is common in eukaryotes, is often found in the middle of the protein sequence, and may function in binding to RNA. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Apr 2013]

GeneCards Summary for YTHDF3 Gene

YTHDF3 (YTH N(6)-Methyladenosine RNA Binding Protein 3) is a Protein Coding gene. An important paralog of this gene is YTHDF1.

UniProtKB/Swiss-Prot for YTHDF3 Gene

  • Specifically recognizes and binds N6-methyladenosine (m6A)-containing RNAs. M6A is a modification present at internal sites of mRNAs and some non-coding RNAs and plays a role in the efficiency of mRNA splicing, processing and stability.

Gene Wiki entry for YTHDF3 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for YTHDF3 Gene

Genomics for YTHDF3 Gene

Regulatory Elements for YTHDF3 Gene

Genomic Location for YTHDF3 Gene

Start:
63,168,553 bp from pter
End:
63,212,788 bp from pter
Size:
44,236 bases
Orientation:
Plus strand

Genomic View for YTHDF3 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for YTHDF3 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for YTHDF3 Gene

Proteins for YTHDF3 Gene

  • Protein details for YTHDF3 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q7Z739-YTHD3_HUMAN
    Recommended name:
    YTH domain-containing family protein 3
    Protein Accession:
    Q7Z739
    Secondary Accessions:
    • B3KXL4
    • Q63Z37
    • Q659A3

    Protein attributes for YTHDF3 Gene

    Size:
    585 amino acids
    Molecular mass:
    63861 Da
    Quaternary structure:
    No Data Available

neXtProt entry for YTHDF3 Gene

Proteomics data for YTHDF3 Gene at MOPED

Post-translational modifications for YTHDF3 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for YTHDF3 Gene

Domains for YTHDF3 Gene

Protein Domains for YTHDF3 Gene

InterPro:
Blocks:
ProtoNet:

Suggested Antigen Peptide Sequences for YTHDF3 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q7Z739

UniProtKB/Swiss-Prot:

YTHD3_HUMAN :
  • Q7Z739
Domain:
  • Contains 1 YTH domain.
genes like me logo Genes that share domains with YTHDF3: view

No data available for Gene Families for YTHDF3 Gene

Function for YTHDF3 Gene

Molecular function for YTHDF3 Gene

UniProtKB/Swiss-Prot Function: Specifically recognizes and binds N6-methyladenosine (m6A)-containing RNAs. M6A is a modification present at internal sites of mRNAs and some non-coding RNAs and plays a role in the efficiency of mRNA splicing, processing and stability.

Gene Ontology (GO) - Molecular Function for YTHDF3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 22190034
GO:0044822 poly(A) RNA binding IDA 22681889
GO:1990247 N6-methyladenosine-containing RNA binding IDA 22575960
genes like me logo Genes that share ontologies with YTHDF3: view

Animal Model Products

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for YTHDF3

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Phenotypes , Animal Models , miRNA , Transcription Factor Targeting and HOMER Transcription for YTHDF3 Gene

Localization for YTHDF3 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for YTHDF3 Gene COMPARTMENTS Subcellular localization image for YTHDF3 gene
Compartment Confidence
cytosol 2
nucleus 2
cytoskeleton 1

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Gene Ontology (GO) - Cellular Components for YTHDF3 Gene

Pathways for YTHDF3 Gene

SuperPathways for YTHDF3 Gene

No Data Available

Interacting Proteins for YTHDF3 Gene

Selected Interacting proteins: Q7Z739-YTHD3_HUMAN for YTHDF3 Gene via UniProtKB I2D

Gene Ontology (GO) - Biological Process for YTHDF3 Gene

None

No data available for Pathways by source for YTHDF3 Gene

Transcripts for YTHDF3 Gene

Unigene Clusters for YTHDF3 Gene

YTH domain family, member 3:
Representative Sequences:

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for YTHDF3

Primer Products

  • OriGene qSTAR qPCR primer pairs in human,mouse,rat for YTHDF3
  • QuantiTect SYBR Green Assays in human,mouse,rat
  • Pre-validated RT² qPCR Primer Assay in human,mouse,rat
  • QuantiFast Probe-based Assays in human,mouse,rat

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for YTHDF3 Gene

No ASD Table

Relevant External Links for YTHDF3 Gene

GeneLoc Exon Structure for
YTHDF3
ECgene alternative splicing isoforms for
YTHDF3

Expression for YTHDF3 Gene

mRNA expression in normal human tissues for YTHDF3 Gene

Integrated Proteomics: protein expression from ProteomicsDB and MOPED for YTHDF3 Gene

SOURCE GeneReport for Unigene cluster for YTHDF3 Gene Hs.491861

genes like me logo Genes that share expressions with YTHDF3: view

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for YTHDF3 Gene

Orthologs for YTHDF3 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for YTHDF3 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia YTHDF3 35
  • 95.38 (n)
  • 98.63 (a)
YTHDF3 36
  • 97 (a)
OneToOne
dog
(Canis familiaris)
Mammalia YTHDF3 35
  • 97.83 (n)
  • 99.49 (a)
YTHDF3 36
  • 94 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Ythdf3 35
  • 96.41 (n)
  • 98.8 (a)
Ythdf3 16
Ythdf3 36
  • 95 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia YTHDF3 36
  • 95 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia YTHDF3 36
  • 92 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Ythdf3 35
  • 96.24 (n)
  • 98.63 (a)
chicken
(Gallus gallus)
Aves YTHDF3 35
  • 88.45 (n)
  • 93.83 (a)
YTHDF3 36
  • 93 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia YTHDF3 36
  • 93 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia Str.8934 35
ythdf3 35
  • 83.97 (n)
  • 90.91 (a)
zebrafish
(Danio rerio)
Actinopterygii -- 35
ythdf3 35
  • 73 (n)
  • 81.36 (a)
ythdf3 36
  • 80 (a)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta CG6422 36
  • 28 (a)
OneToMany
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes -- 36
  • 30 (a)
OneToMany
barley
(Hordeum vulgare)
Liliopsida Hv.5568 35
wheat
(Triticum aestivum)
Liliopsida Ta.9583 35
sea squirt
(Ciona savignyi)
Ascidiacea CSA.6332 36
  • 43 (a)
OneToMany
Species with no ortholog for YTHDF3:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chimpanzee (Pan troglodytes)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • worm (Caenorhabditis elegans)

Evolution for YTHDF3 Gene

ENSEMBL:
Gene Tree for YTHDF3 (if available)
TreeFam:
Gene Tree for YTHDF3 (if available)

Paralogs for YTHDF3 Gene

Paralogs for YTHDF3 Gene

genes like me logo Genes that share paralogs with YTHDF3: view

Variants for YTHDF3 Gene

Sequence variations from dbSNP and Humsavar for YTHDF3 Gene

SNP ID Clin Chr 08 pos Sequence Context AA Info Type MAF
rs7464 -- 63,212,398(+) ATACC(A/G)TGCAT utr-variant-3-prime, nc-transcript-variant
rs1435457 -- 63,171,669(+) CAGCT(A/C)GTAAA intron-variant
rs1435458 -- 63,171,829(+) AACAC(A/G)TAATC intron-variant
rs2043525 -- 63,195,289(+) GAAGC(G/T)GTAAT intron-variant
rs2217827 -- 63,174,543(+) AATTC(A/G)GGACC intron-variant

Structural Variations from Database of Genomic Variants (DGV) for YTHDF3 Gene

Variant ID Type Subtype PubMed ID
nsv890965 CNV Gain+Loss 21882294
nsv890966 CNV Loss 21882294
nsv831342 CNV Gain 17160897
nsv890967 CNV Gain 21882294
esv2677763 CNV Deletion 23128226

Relevant External Links for YTHDF3 Gene

HapMap Linkage Disequilibrium report
YTHDF3

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for YTHDF3 Gene

Disorders for YTHDF3 Gene

Relevant External Links for YTHDF3

Genetic Association Database (GAD)
YTHDF3
genes like me logo Genes that share disorders with YTHDF3: view

No data available for UniProtKB/Swiss-Prot for YTHDF3 Gene

Publications for YTHDF3 Gene

  1. Topology of the human and mouse m6A RNA methylomes revealed by m6A- seq. (PMID: 22575960) Dominissini D. … Rechavi G. (Nature 2012) 2 3 4
  2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4
  3. A quantitative atlas of mitotic phosphorylation. (PMID: 18669648) Dephoure N. … Gygi S.P. (Proc. Natl. Acad. Sci. U.S.A. 2008) 3 4
  4. Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis. (PMID: 20068231) Olsen J.V. … Mann M. (Sci. Signal. 2010) 3 4
  5. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4

Products for YTHDF3 Gene

Sources for YTHDF3 Gene

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