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Aliases for YTHDF2 Gene

Aliases for YTHDF2 Gene

  • YTH N(6)-Methyladenosine RNA Binding Protein 2 2 3
  • High-Glucose-Regulated Protein 8 3 4
  • Renal Carcinoma Antigen NY-REN-2 3 4
  • CLL-Associated Antigen KW-14 3 4
  • YTH Domain Family, Member 2 2 3
  • HGRG8 3 4
  • YTH Domain-Containing Family Protein 2 3
  • YTH Domain Family 2 2
  • 9430020E02Rik 3
  • NY-REN-2 3
  • CAHL 3

External Ids for YTHDF2 Gene

Summaries for YTHDF2 Gene

Entrez Gene Summary for YTHDF2 Gene

  • This gene encodes a member of the YTH (YT521-B homology) superfamily containing YTH domain. The YTH domain is typical for the eukaryotes and is particularly abundant in plants. The YTH domain is usually located in the middle of the protein sequence and may function in binding to RNA. In addition to a YTH domain, this protein has a proline rich region which may be involved in signal transduction. An Alu-rich domain has been identified in one of the introns of this gene, which is thought to be associated with human longevity. In addition, reciprocal translocations between this gene and the Runx1 (AML1) gene on chromosome 21 has been observed in patients with acute myeloid leukemia. This gene was initially mapped to chromosome 14, which was later turned out to be a pseudogene. Alternatively spliced transcript variants encoding different isoforms have been identified in this gene. [provided by RefSeq, Oct 2012]

GeneCards Summary for YTHDF2 Gene

YTHDF2 (YTH N(6)-Methyladenosine RNA Binding Protein 2) is a Protein Coding gene. Diseases associated with YTHDF2 include myeloid leukemia. An important paralog of this gene is YTHDF1.

UniProtKB/Swiss-Prot for YTHDF2 Gene

  • Specifically recognizes and binds N6-methyladenosine (m6A)-containing RNAs. M6A is a modification present at internal sites of mRNAs and some non-coding RNAs and plays a role in the efficiency of mRNA splicing, processing and stability (PubMed:22575960, PubMed:24284625, PubMed:25412658, PubMed:25412661). Acts as a regulator of mRNA stability: binding to m6A-containing mRNAs results in the localization to mRNA decay sites, such as processing bodies (P-bodies), leading to mRNA degradation (PubMed:24284625).

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for YTHDF2 Gene

Genomics for YTHDF2 Gene

Genomic Location for YTHDF2 Gene

Start:
28,736,621 bp from pter
End:
28,769,775 bp from pter
Size:
33,155 bases
Orientation:
Plus strand

Genomic View for YTHDF2 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for YTHDF2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for YTHDF2 Gene

Regulatory Elements for YTHDF2 Gene

Proteins for YTHDF2 Gene

  • Protein details for YTHDF2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9Y5A9-YTHD2_HUMAN
    Recommended name:
    YTH domain-containing family protein 2
    Protein Accession:
    Q9Y5A9
    Secondary Accessions:
    • A6NKG4
    • A8K966
    • B4E1G7
    • D3DPM8
    • Q5VSZ9
    • Q8TDH0
    • Q9BUJ5

    Protein attributes for YTHDF2 Gene

    Size:
    579 amino acids
    Molecular mass:
    62334 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=AAD42861.1; Type=Frameshift; Positions=565; Evidence={ECO:0000305}; Sequence=AAF08813.1; Type=Frameshift; Positions=565; Evidence={ECO:0000305}; Sequence=AAL99921.1; Type=Miscellaneous discrepancy; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for YTHDF2 Gene

    Alternative splice isoforms for YTHDF2 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for YTHDF2 Gene

Proteomics data for YTHDF2 Gene at MOPED

Post-translational modifications for YTHDF2 Gene

  • Modification sites at PhosphoSitePlus
  • Ubiquitination at Lys401 and Lys408

Other Protein References for YTHDF2 Gene

No data available for DME Specific Peptides for YTHDF2 Gene

Domains for YTHDF2 Gene

Protein Domains for YTHDF2 Gene

InterPro:
Blocks:
ProtoNet:

Suggested Antigen Peptide Sequences for YTHDF2 Gene

Graphical View of Domain Structure for InterPro Entry

Q9Y5A9

UniProtKB/Swiss-Prot:

YTHD2_HUMAN
Domain:
  • Contains 1 YTH domain.:
    • Q9Y5A9
genes like me logo Genes that share domains with YTHDF2: view

No data available for Gene Families for YTHDF2 Gene

Function for YTHDF2 Gene

Molecular function for YTHDF2 Gene

UniProtKB/Swiss-Prot Function: Specifically recognizes and binds N6-methyladenosine (m6A)-containing RNAs. M6A is a modification present at internal sites of mRNAs and some non-coding RNAs and plays a role in the efficiency of mRNA splicing, processing and stability (PubMed:22575960, PubMed:24284625, PubMed:25412658, PubMed:25412661). Acts as a regulator of mRNA stability: binding to m6A-containing mRNAs results in the localization to mRNA decay sites, such as processing bodies (P-bodies), leading to mRNA degradation (PubMed:24284625).

Gene Ontology (GO) - Molecular Function for YTHDF2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0044822 poly(A) RNA binding IDA 22658674
GO:1990247 N6-methyladenosine-containing RNA binding IDA 22575960
genes like me logo Genes that share ontologies with YTHDF2: view

Phenotypes for YTHDF2 Gene

genes like me logo Genes that share phenotypes with YTHDF2: view

miRNA for YTHDF2 Gene

miRTarBase miRNAs that target YTHDF2

No data available for Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targeting and HOMER Transcription for YTHDF2 Gene

Localization for YTHDF2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for YTHDF2 Gene

Cytoplasm, P-body.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for YTHDF2 Gene COMPARTMENTS Subcellular localization image for YTHDF2 gene
Compartment Confidence
cytosol 2
nucleus 2

Gene Ontology (GO) - Cellular Components for YTHDF2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000932 cytoplasmic mRNA processing body IDA 24284625
genes like me logo Genes that share ontologies with YTHDF2: view

Pathways for YTHDF2 Gene

SuperPathways for YTHDF2 Gene

No Data Available

Gene Ontology (GO) - Biological Process for YTHDF2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006959 humoral immune response TAS 10508479
GO:0043488 regulation of mRNA stability IMP 24284625
genes like me logo Genes that share ontologies with YTHDF2: view

No data available for Pathways by source for YTHDF2 Gene

Transcripts for YTHDF2 Gene

Unigene Clusters for YTHDF2 Gene

YTH domain family, member 2:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for YTHDF2 Gene

ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5 ^ 6a · 6b · 6c · 6d · 6e ^ 7 ^ 8
SP1: - - - -
SP2: - -
SP3:
SP4:
SP5: - -
SP6: - -
SP7: - - - - - - - -

Relevant External Links for YTHDF2 Gene

GeneLoc Exon Structure for
YTHDF2
ECgene alternative splicing isoforms for
YTHDF2

Expression for YTHDF2 Gene

mRNA expression in normal human tissues for YTHDF2 Gene

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for YTHDF2 Gene

SOURCE GeneReport for Unigene cluster for YTHDF2 Gene Hs.532286

genes like me logo Genes that share expressions with YTHDF2: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for YTHDF2 Gene

Orthologs for YTHDF2 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for YTHDF2 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia YTHDF2 35
  • 99.94 (n)
  • 100 (a)
YTHDF2 36
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia YTHDF2 35
  • 97.24 (n)
  • 99.65 (a)
YTHDF2 36
  • 99 (a)
OneToOne
dog
(Canis familiaris)
Mammalia YTHDF2 35
  • 96.74 (n)
  • 98.58 (a)
YTHDF2 36
  • 97 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Ythdf2 35
  • 95.68 (n)
  • 99.65 (a)
Ythdf2 16
Ythdf2 36
  • 100 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia YTHDF2 36
  • 96 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia YTHDF2 36
  • 87 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Ythdf2 35
  • 94.52 (n)
  • 98.1 (a)
chicken
(Gallus gallus)
Aves YTHDF2 35
  • 82.86 (n)
  • 93.01 (a)
YTHDF2 36
  • 89 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia YTHDF2 36
  • 92 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia ythdf2 35
  • 70.08 (n)
  • 76.84 (a)
zebrafish
(Danio rerio)
Actinopterygii yth2 35
  • 72.81 (n)
  • 78.55 (a)
yth2 36
  • 71 (a)
OneToOne
zgc56224 35
fruit fly
(Drosophila melanogaster)
Insecta CG6422 36
  • 28 (a)
OneToMany
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes -- 36
  • 30 (a)
OneToMany
rice
(Oryza sativa)
Liliopsida Os.8783 35
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.4206 35
sea squirt
(Ciona savignyi)
Ascidiacea CSA.6332 36
  • 45 (a)
OneToMany
Species with no ortholog for YTHDF2:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for YTHDF2 Gene

ENSEMBL:
Gene Tree for YTHDF2 (if available)
TreeFam:
Gene Tree for YTHDF2 (if available)

Paralogs for YTHDF2 Gene

Paralogs for YTHDF2 Gene

Selected SIMAP similar genes for YTHDF2 Gene using alignment to 4 proteins:

Pseudogenes.org Pseudogenes for YTHDF2 Gene

genes like me logo Genes that share paralogs with YTHDF2: view

Variants for YTHDF2 Gene

Sequence variations from dbSNP and Humsavar for YTHDF2 Gene

SNP ID Clin Chr 01 pos Sequence Context AA Info Type MAF
rs476178 -- 28,764,690(+) gcgtg(A/G)gccat intron-variant
rs487093 -- 28,757,786(+) CTTGG(C/T)ATTTT intron-variant
rs490716 -- 28,758,138(+) TGGTG(A/G)TTTAC intron-variant
rs514037 -- 28,755,566(-) ACCAC(A/G)CTGCA intron-variant
rs602345 -- 28,748,780(+) AGAAC(C/T)TTTCC intron-variant

Structural Variations from Database of Genomic Variants (DGV) for YTHDF2 Gene

Variant ID Type Subtype PubMed ID
nsv509080 CNV Insertion 20534489
nsv160265 CNV Loss 16902084
esv2745830 CNV Deletion 23290073

Relevant External Links for YTHDF2 Gene

HapMap Linkage Disequilibrium report
YTHDF2
Human Gene Mutation Database (HGMD)
YTHDF2

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for YTHDF2 Gene

Disorders for YTHDF2 Gene

(1) MalaCards Diseases for YTHDF2 Gene

Search for YTHDF2 Gene in MalaCards »

Relevant External Links for YTHDF2

Genetic Association Database (GAD)
YTHDF2
Human Genome Epidemiology (HuGE) Navigator
YTHDF2
genes like me logo Genes that share disorders with YTHDF2: view

No data available for UniProtKB/Swiss-Prot for YTHDF2 Gene

Publications for YTHDF2 Gene

  1. Antigens recognized by autologous antibody in patients with renal- cell carcinoma. (PMID: 10508479) Scanlan M.J. … Old L.J. (Int. J. Cancer 1999) 2 3 4
  2. Topology of the human and mouse m6A RNA methylomes revealed by m6A- seq. (PMID: 22575960) Dominissini D. … Rechavi G. (Nature 2012) 2 3 4
  3. A polymorphism of the YTHDF2 gene (1p35) located in an Alu-rich genomic domain is associated with human longevity. (PMID: 16799135) Cardelli M. … Franceschi C. (J. Gerontol. A Biol. Sci. Med. Sci. 2006) 3 48
  4. N-methyladenosine-dependent regulation of messenger RNA stability. (PMID: 24284625) Wang X. … He C. (Nature 2014) 3 4
  5. PRP19 transforms into a sensor of RPA-ssDNA after DNA damage and drives ATR activation via a ubiquitin-mediated circuitry. (PMID: 24332808) Marechal A. … Zou L. (Mol. Cell 2014) 3

Products for YTHDF2 Gene

Sources for YTHDF2 Gene

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