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Aliases for YTHDF2 Gene

Aliases for YTHDF2 Gene

  • YTH N6-Methyladenosine RNA Binding Protein 2 2 3
  • YTH N(6)-Methyladenosine RNA Binding Protein 2 2 3 5
  • High-Glucose-Regulated Protein 8 3 4
  • Renal Carcinoma Antigen NY-REN-2 3 4
  • CLL-Associated Antigen KW-14 3 4
  • YTH Domain Family, Member 2 2 3
  • HGRG8 3 4
  • YTH Domain Family 2 2
  • 9430020E02Rik 3
  • NY-REN-2 3
  • CAHL 3

External Ids for YTHDF2 Gene

Previous GeneCards Identifiers for YTHDF2 Gene

  • GC01P028884
  • GC01P028935
  • GC01P029063
  • GC01P027315

Summaries for YTHDF2 Gene

Entrez Gene Summary for YTHDF2 Gene

  • This gene encodes a member of the YTH (YT521-B homology) superfamily containing YTH domain. The YTH domain is typical for the eukaryotes and is particularly abundant in plants. The YTH domain is usually located in the middle of the protein sequence and may function in binding to RNA. In addition to a YTH domain, this protein has a proline rich region which may be involved in signal transduction. An Alu-rich domain has been identified in one of the introns of this gene, which is thought to be associated with human longevity. In addition, reciprocal translocations between this gene and the Runx1 (AML1) gene on chromosome 21 has been observed in patients with acute myeloid leukemia. This gene was initially mapped to chromosome 14, which was later turned out to be a pseudogene. Alternatively spliced transcript variants encoding different isoforms have been identified in this gene. [provided by RefSeq, Oct 2012]

GeneCards Summary for YTHDF2 Gene

YTHDF2 (YTH N6-Methyladenosine RNA Binding Protein 2) is a Protein Coding gene. GO annotations related to this gene include poly(A) RNA binding and N6-methyladenosine-containing RNA binding. An important paralog of this gene is YTHDF1.

UniProtKB/Swiss-Prot for YTHDF2 Gene

  • Specifically recognizes and binds N6-methyladenosine (m6A)-containing RNAs, and regulates mRNA stability (PubMed:24284625, PubMed:26046440, PubMed:26318451). M6A is a modification present at internal sites of mRNAs and some non-coding RNAs and plays a role in the efficiency of mRNA splicing, processing and stability (PubMed:22575960, PubMed:24284625, PubMed:25412658, PubMed:25412661). Acts as a regulator of mRNA stability: binding to m6A-containing mRNAs results in the localization to mRNA decay sites, such as processing bodies (P-bodies), leading to mRNA degradation (PubMed:24284625, PubMed:26046440). Also acts as a promoter of cap-independent mRNA translation following heat shock stress: upon stress, relocalizes to the nucleus and specifically binds mRNAs with some m6A methylation mark at their 5-UTR, protecting demethylation of mRNAs by FTO, thereby promoting cap-independent mRNA translation (PubMed:26458103).

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for YTHDF2 Gene

Genomics for YTHDF2 Gene

Regulatory Elements for YTHDF2 Gene

Enhancers for YTHDF2 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around YTHDF2 on UCSC Golden Path with GeneCards custom track

Promoters for YTHDF2 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around YTHDF2 on UCSC Golden Path with GeneCards custom track

Genomic Location for YTHDF2 Gene

Chromosome:
1
Start:
28,736,621 bp from pter
End:
28,769,775 bp from pter
Size:
33,155 bases
Orientation:
Plus strand

Genomic View for YTHDF2 Gene

Genes around YTHDF2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
YTHDF2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for YTHDF2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for YTHDF2 Gene

Proteins for YTHDF2 Gene

  • Protein details for YTHDF2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9Y5A9-YTHD2_HUMAN
    Recommended name:
    YTH domain-containing family protein 2
    Protein Accession:
    Q9Y5A9
    Secondary Accessions:
    • A6NKG4
    • A8K966
    • B4E1G7
    • D3DPM8
    • Q5VSZ9
    • Q8TDH0
    • Q9BUJ5

    Protein attributes for YTHDF2 Gene

    Size:
    579 amino acids
    Molecular mass:
    62334 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=AAD42861.1; Type=Frameshift; Positions=565; Evidence={ECO:0000305}; Sequence=AAF08813.1; Type=Frameshift; Positions=565; Evidence={ECO:0000305}; Sequence=AAL99921.1; Type=Miscellaneous discrepancy; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for YTHDF2 Gene

    Alternative splice isoforms for YTHDF2 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for YTHDF2 Gene

Proteomics data for YTHDF2 Gene at MOPED

Post-translational modifications for YTHDF2 Gene

  • Ubiquitination at Lys 401 and Lys 408
  • Modification sites at PhosphoSitePlus

Other Protein References for YTHDF2 Gene

No data available for DME Specific Peptides for YTHDF2 Gene

Domains & Families for YTHDF2 Gene

Protein Domains for YTHDF2 Gene

InterPro:
Blocks:
ProtoNet:

Suggested Antigen Peptide Sequences for YTHDF2 Gene

Graphical View of Domain Structure for InterPro Entry

Q9Y5A9

UniProtKB/Swiss-Prot:

YTHD2_HUMAN :
  • Contains 1 YTH domain.
Domain:
  • Contains 1 YTH domain.
genes like me logo Genes that share domains with YTHDF2: view

No data available for Gene Families for YTHDF2 Gene

Function for YTHDF2 Gene

Molecular function for YTHDF2 Gene

UniProtKB/Swiss-Prot Function:
Specifically recognizes and binds N6-methyladenosine (m6A)-containing RNAs, and regulates mRNA stability (PubMed:24284625, PubMed:26046440, PubMed:26318451). M6A is a modification present at internal sites of mRNAs and some non-coding RNAs and plays a role in the efficiency of mRNA splicing, processing and stability (PubMed:22575960, PubMed:24284625, PubMed:25412658, PubMed:25412661). Acts as a regulator of mRNA stability: binding to m6A-containing mRNAs results in the localization to mRNA decay sites, such as processing bodies (P-bodies), leading to mRNA degradation (PubMed:24284625, PubMed:26046440). Also acts as a promoter of cap-independent mRNA translation following heat shock stress: upon stress, relocalizes to the nucleus and specifically binds mRNAs with some m6A methylation mark at their 5-UTR, protecting demethylation of mRNAs by FTO, thereby promoting cap-independent mRNA translation (PubMed:26458103).
UniProtKB/Swiss-Prot Induction:
Following heat shock stress.

Gene Ontology (GO) - Molecular Function for YTHDF2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:1990247 N6-methyladenosine-containing RNA binding IDA 22575960
genes like me logo Genes that share ontologies with YTHDF2: view
genes like me logo Genes that share phenotypes with YTHDF2: view

Animal Model Products

miRNA for YTHDF2 Gene

miRTarBase miRNAs that target YTHDF2

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for YTHDF2 Gene

Localization for YTHDF2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for YTHDF2 Gene

Cytoplasm, cytosol. Nucleus. Cytoplasm, P-body. Note=Localizes to the cytosol and relocates to the nucleus following heat shock stress (PubMed:26458103). {ECO:0000269 PubMed:26458103}.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for YTHDF2 Gene COMPARTMENTS Subcellular localization image for YTHDF2 gene
Compartment Confidence
cytosol 5
nucleus 5

Gene Ontology (GO) - Cellular Components for YTHDF2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005829 cytosol IDA 26458103
genes like me logo Genes that share ontologies with YTHDF2: view

Pathways & Interactions for YTHDF2 Gene

SuperPathways for YTHDF2 Gene

No Data Available

Gene Ontology (GO) - Biological Process for YTHDF2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006959 humoral immune response TAS 10508479
GO:1903679 positive regulation of cap-independent translational initiation IDA 26458103
genes like me logo Genes that share ontologies with YTHDF2: view

No data available for Pathways by source and SIGNOR curated interactions for YTHDF2 Gene

Drugs & Compounds for YTHDF2 Gene

No Compound Related Data Available

Transcripts for YTHDF2 Gene

Unigene Clusters for YTHDF2 Gene

YTH domain family, member 2:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for YTHDF2 Gene

ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5 ^ 6a · 6b · 6c · 6d · 6e ^ 7 ^ 8
SP1: - - - -
SP2: - -
SP3:
SP4:
SP5: - -
SP6: - -
SP7: - - - - - - - -

Relevant External Links for YTHDF2 Gene

GeneLoc Exon Structure for
YTHDF2
ECgene alternative splicing isoforms for
YTHDF2

Expression for YTHDF2 Gene

mRNA expression in normal human tissues for YTHDF2 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for YTHDF2 Gene

This gene is overexpressed in Bone (16.7) and Breast (8.9).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for YTHDF2 Gene



SOURCE GeneReport for Unigene cluster for YTHDF2 Gene Hs.532286

genes like me logo Genes that share expression patterns with YTHDF2: view

Protein tissue co-expression partners for YTHDF2 Gene

- Elite partner

Primer Products

No data available for mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for YTHDF2 Gene

Orthologs for YTHDF2 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for YTHDF2 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia YTHDF2 35
  • 97.24 (n)
  • 99.65 (a)
YTHDF2 36
  • 99 (a)
OneToOne
dog
(Canis familiaris)
Mammalia YTHDF2 35
  • 96.74 (n)
  • 98.58 (a)
YTHDF2 36
  • 97 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Ythdf2 35
  • 95.68 (n)
  • 99.65 (a)
Ythdf2 16
Ythdf2 36
  • 100 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia YTHDF2 35
  • 99.94 (n)
  • 100 (a)
YTHDF2 36
  • 100 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Ythdf2 35
  • 94.52 (n)
  • 98.1 (a)
oppossum
(Monodelphis domestica)
Mammalia YTHDF2 36
  • 96 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia YTHDF2 36
  • 87 (a)
OneToOne
chicken
(Gallus gallus)
Aves YTHDF2 35
  • 82.86 (n)
  • 93.01 (a)
YTHDF2 36
  • 89 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia YTHDF2 36
  • 92 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia ythdf2 35
  • 70.08 (n)
  • 76.84 (a)
zebrafish
(Danio rerio)
Actinopterygii yth2 35
  • 72.81 (n)
  • 78.55 (a)
zgc56224 35
yth2 36
  • 71 (a)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta CG6422 36
  • 28 (a)
OneToMany
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes -- 36
  • 30 (a)
OneToMany
rice
(Oryza sativa)
Liliopsida Os.8783 35
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.4206 35
sea squirt
(Ciona savignyi)
Ascidiacea CSA.6332 36
  • 45 (a)
OneToMany
Species with no ortholog for YTHDF2:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for YTHDF2 Gene

ENSEMBL:
Gene Tree for YTHDF2 (if available)
TreeFam:
Gene Tree for YTHDF2 (if available)

Paralogs for YTHDF2 Gene

Paralogs for YTHDF2 Gene

(4) SIMAP similar genes for YTHDF2 Gene using alignment to 4 proteins:

Pseudogenes.org Pseudogenes for YTHDF2 Gene

genes like me logo Genes that share paralogs with YTHDF2: view

Variants for YTHDF2 Gene

Sequence variations from dbSNP and Humsavar for YTHDF2 Gene

SNP ID Clin Chr 01 pos Sequence Context AA Info Type
rs16838382 - 28,742,920(+) CATTA(C/G)TAGTA reference, missense
rs35288745 - 28,743,630(+) AACGG(A/C/G/T)GCCTT reference, missense
rs476178 -- 28,764,690(+) gcgtg(A/G)gccat intron-variant
rs487093 -- 28,757,786(+) CTTGG(C/T)ATTTT intron-variant
rs490716 -- 28,758,138(+) TGGTG(A/G)TTTAC intron-variant

Structural Variations from Database of Genomic Variants (DGV) for YTHDF2 Gene

Variant ID Type Subtype PubMed ID
nsv509080 CNV Insertion 20534489
nsv160265 CNV Loss 16902084
esv2745830 CNV Deletion 23290073

Variation tolerance for YTHDF2 Gene

Residual Variation Intolerance Score: 12.1% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.35; 26.67% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for YTHDF2 Gene

Human Gene Mutation Database (HGMD)
YTHDF2

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for YTHDF2 Gene

Disorders for YTHDF2 Gene

Relevant External Links for YTHDF2

Genetic Association Database (GAD)
YTHDF2
Human Genome Epidemiology (HuGE) Navigator
YTHDF2
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
YTHDF2

No disorders were found for YTHDF2 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for YTHDF2 Gene

Publications for YTHDF2 Gene

  1. Topology of the human and mouse m6A RNA methylomes revealed by m6A- seq. (PMID: 22575960) Dominissini D. … Rechavi G. (Nature 2012) 2 3 4 67
  2. Antigens recognized by autologous antibody in patients with renal- cell carcinoma. (PMID: 10508479) Scanlan M.J. … Old L.J. (Int. J. Cancer 1999) 2 3
  3. Temporal proteomics of NGF-TrkA signaling identifies an inhibitory role for the E3 ligase Cbl-b in neuroblastoma cell differentiation. (PMID: 25921289) Emdal K.B. … Olsen J.V. (Sci Signal 2015) 3
  4. Quantitative Proteomics Reveals Dynamic Interactions of the Minichromosome Maintenance Complex (MCM) in the Cellular Response to Etoposide Induced DNA Damage. (PMID: 25963833) Drissi R. … Boisvert F.M. (Mol. Cell Proteomics 2015) 3
  5. N(6)-methyladenosine modulates messenger RNA translation efficiency. (PMID: 26046440) Wang X. … He C. (Cell 2015) 3

Products for YTHDF2 Gene

Sources for YTHDF2 Gene

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