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YTHDF2 Gene

protein-coding   GIFtS: 53
GCID: GC01P029063

YTH Domain Family, Member 2

(Previous name: YTH domain family 2)
  See YTHDF2-related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
YTH Domain Family, Member 21 2     YTH Domain Family 21
High-Glucose-Regulated Protein 82 3     9430020E02Rik2
Renal Carcinoma Antigen NY-REN-22 3     NY-REN-22
HGRG82 3     YTH Domain-Containing Family Protein 22
CLL-Associated Antigen KW-142 3     

External Ids:    HGNC: 316751   Entrez Gene: 514412   Ensembl: ENSG000001984927   OMIM: 6106405   UniProtKB: Q9Y5A93   

Export aliases for YTHDF2 gene to outside databases

Previous GC identifers: GC01P028751 GC01P028884 GC01P028935 GC01P027315


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for YTHDF2 Gene:
This gene encodes a member of the YTH (YT521-B homology) superfamily containing YTH domain. The YTH domain is
typical for the eukaryotes and is particularly abundant in plants. The YTH domain is usually located in the
middle of the protein sequence and may function in binding to RNA. In addition to a YTH domain, this protein has
a proline rich region which may be involved in signal transduction. An Alu-rich domain has been identified in one
of the introns of this gene, which is thought to be associated with human longevity. In addition, reciprocal
translocations between this gene and the Runx1 (AML1) gene on chromosome 21 has been observed in patients with
acute myeloid leukemia. This gene was initially mapped to chromosome 14, which was later turned out to be a
pseudogene. Alternatively spliced transcript variants encoding different isoforms have been identified in this
gene. (provided by RefSeq, Oct 2012)

GeneCards Summary for YTHDF2 Gene:
YTHDF2 (YTH domain family, member 2) is a protein-coding gene. Diseases associated with YTHDF2 include acute myeloid leukemia, and myeloid leukemia. An important paralog of this gene is YTHDF1.

UniProtKB/Swiss-Prot: YTHD2_HUMAN, Q9Y5A9
Function: Specifically recognizes and binds N6-methyladenosine (m6A)-containing RNAs. M6A is a modification
present at internal sites of mRNAs and some non-coding RNAs and plays a role in the efficiency of mRNA splicing,
processing and stability. Acts as a regulator of mRNA stability: binding to m6A-containing mRNAs results in the
localization of to mRNA decay sites, such as processing bodies (P-bodies), leading to mRNA degradation




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000001.10  NC_018912.2  NT_032977.10  
Regulatory elements:
   Regulatory transcription factor binding sites in the YTHDF2 gene promoter:
         HFH-3   AML1a   AP-2alpha isoform 2   E4BP4   C/EBPalpha   PPAR-alpha   FOXI1   S8   AP-2alpha   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidYTHDF2 promoter sequence
   Search Chromatin IP Primers for YTHDF2

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat YTHDF2


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 1p35   Ensembl cytogenetic band:  1p35.3   HGNC cytogenetic band: 1p35

YTHDF2 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
YTHDF2 gene location

GeneLoc information about chromosome 1         GeneLoc Exon Structure

GeneLoc location for GC01P029063:  view genomic region     (about GC identifiers)

Start:
29,063,133 bp from pter      End:
29,096,287 bp from pter
Size:
33,155 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., eBioscience, and/or antibodies-online,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., eBioscience, and/or antibodies-online, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, Cloud-Clone Corp, antibodies-online, and/or others.)
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UniProtKB/Swiss-Prot: YTHD2_HUMAN, Q9Y5A9 (See protein sequence)
Recommended Name: YTH domain-containing family protein 2  
Size: 579 amino acids; 62334 Da
Sequence caution: Sequence=AAD42861.1; Type=Frameshift; Positions=565; Sequence=AAF08813.1; Type=Frameshift;
Positions=565; Sequence=AAL99921.1; Type=Miscellaneous discrepancy;
Secondary accessions: A6NKG4 A8K966 B4E1G7 D3DPM8 Q5VSZ9 Q8TDH0 Q9BUJ5
Alternative splicing: 2 isoforms:  Q9Y5A9-1   Q9Y5A9-2   (May be due to intron retention. No experimental confirmation available)

Explore the universe of human proteins at neXtProt for YTHDF2: NX_Q9Y5A9

Explore proteomics data for YTHDF2 at MOPED

Post-translational modifications: 

  • Ubiquitination2 at Lys401, Lys408
  • Modification sites at PhosphoSitePlus

  • See YTHDF2 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (3 alternative transcripts): 
    NP_001166299.1  NP_001166599.1  NP_057342.2  

    ENSEMBL proteins: 
     ENSP00000474446   ENSP00000362918   ENSP00000474784   ENSP00000444660   ENSP00000439394  

    YTHDF2 Human Recombinant Protein Products:

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    Cloud-Clone Corp. Proteins for YTHDF2

     
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    antibodies-online proteins for YTHDF2 (2 products) 

     
    antibodies-online peptides for YTHDF2

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    antibodies-online antibodies for YTHDF2 (13 products) 

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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    1 InterPro protein domain:
     IPR007275 YTH_domain

    Graphical View of Domain Structure for InterPro Entry Q9Y5A9

    ProtoNet protein and cluster: Q9Y5A9

    1 Blocks protein domain: IPB007275 YT521-B-like protein

    UniProtKB/Swiss-Prot: YTHD2_HUMAN, Q9Y5A9
    Similarity: Contains 1 YTH domain


    Find genes that share domains with YTHDF2           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: YTHD2_HUMAN, Q9Y5A9
    Function: Specifically recognizes and binds N6-methyladenosine (m6A)-containing RNAs. M6A is a modification
    present at internal sites of mRNAs and some non-coding RNAs and plays a role in the efficiency of mRNA splicing,
    processing and stability. Acts as a regulator of mRNA stability: binding to m6A-containing mRNAs results in the
    localization of to mRNA decay sites, such as processing bodies (P-bodies), leading to mRNA degradation

         Gene Ontology (GO): 2 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0044822poly(A) RNA binding IDA--
    GO:1990247N6-methyladenosine-containing RNA binding IDA--
         
    Find genes that share ontologies with YTHDF2           About GenesLikeMe


    Phenotypes:
         2 GenomeRNAi human phenotypes for YTHDF2:
     Decreased viability with pacli  Increased gamma-H2AX phosphory 

         1 MGI phenotypic allele for Ythdf2 (no phenotypes)

    Find genes that share phenotypes with YTHDF2           About GenesLikeMe

    Animal Models:
       genOway: Develop your customized and physiologically relevant rodent model for YTHDF2

    miRNA
    Products:
        
    miRTarBase miRNAs that target YTHDF2:
    hsa-mir-615-3p (MIRT040054), hsa-mir-106b-5p (MIRT044257), hsa-mir-1 (MIRT023842)

    Block miRNA regulation of human, mouse, rat YTHDF2 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate YTHDF2 (see all 33):
    hsa-miR-3607-3p hsa-miR-200a hsa-miR-301a hsa-miR-519a hsa-miR-141 hsa-miR-130b hsa-miR-181b hsa-miR-301b
    SwitchGear 3'UTR luciferase reporter plasmidYTHDF2 3' UTR sequence
    Inhib. RNA
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    Predesigned siRNA for gene silencing in human, mouse, rat YTHDF2

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    Sino Biological Human cDNA Clone for YTHDF2
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for YTHDF2
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    Addgene plasmids for YTHDF2 

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    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    YTHD2_HUMAN, Q9Y5A9: Cytoplasm, P-body
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    cytosol2
    nucleus2

    Gene Ontology (GO): 1 cellular component term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000932cytoplasmic mRNA processing body IDA--

    Find genes that share ontologies with YTHDF2           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for YTHDF2
    Interactions:

        Search GeneGlobe Interaction Network for YTHDF2

    STRING Interaction Network Preview (showing 5 interactants - click image to see 19)

    Selected Interacting proteins for YTHDF2 (Q9Y5A93 ENSP000003629184) via UniProtKB, MINT, STRING, and/or I2D (see all 33)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    HNRNPH1P319433, ENSP000003491684I2D: score=1 STRING: ENSP00000349168
    MEPCEQ7L2J03, ENSP000003085464I2D: score=1 STRING: ENSP00000308546
    SMAD3P840223, ENSP000003329734I2D: score=1 STRING: ENSP00000332973
    HNRNPA1P096513, ENSP000003418264I2D: score=1 STRING: ENSP00000341826
    POT1Q9NUX53, ENSP000003502494I2D: score=1 STRING: ENSP00000350249
    About this table

    Gene Ontology (GO): 2 biological process terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006959humoral immune response TAS10508479
    GO:0043488regulation of mRNA stability IMP--

    Find genes that share ontologies with YTHDF2           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for YTHDF2 (YTHD2)



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for YTHDF2 gene (3 alternative transcripts): 
    NM_001172828.1  NM_001173128.1  NM_016258.2  

    Unigene Cluster for YTHDF2:

    YTH domain family, member 2
    Hs.532286  [show with all ESTs]
    Unigene Representative Sequence: NM_016258
    9 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000474884 ENST00000373812(uc001brc.3 uc010ofx.2 uc001bre.3)
    ENST00000478283 ENST00000496288 ENST00000475796 ENST00000476976 ENST00000468863
    ENST00000542507(uc021okf.1) ENST00000541996
    miRNA
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    Block miRNA regulation of human, mouse, rat YTHDF2 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate YTHDF2 (see all 33):
    hsa-miR-3607-3p hsa-miR-200a hsa-miR-301a hsa-miR-519a hsa-miR-141 hsa-miR-130b hsa-miR-181b hsa-miR-301b
    SwitchGear 3'UTR luciferase reporter plasmidYTHDF2 3' UTR sequence
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    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 3): YTHDF2 (NM_016258)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for YTHDF2
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat YTHDF2
    Addgene plasmids for YTHDF2 
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    OriGene qPCR primer pairs and template standards for YTHDF2
    OriGene qSTAR qPCR primer pairs in human, mouse for YTHDF2
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat YTHDF2
      QuantiTect SYBR Green Assays in human, mouse, rat YTHDF2
      QuantiFast Probe-based Assays in human, mouse, rat YTHDF2

    Additional mRNA sequence: 

    AB451335.1 AB451484.1 AF155095.1 AF192968.1 AK074276.1 AK292581.1 AK303833.1 BC002559.2 

    23 DOTS entries:

    DT.448634  DT.202769  DT.95166815  DT.100884786  DT.100884782  DT.120759786  DT.100884776  DT.100884781 
    DT.120759785  DT.121431552  DT.97847970  DT.121431566  DT.99971591  DT.100721532  DT.100884785  DT.101964561 
    DT.121431538  DT.121431544  DT.121431549  DT.95166788  DT.95166857  DT.97777074  DT.91812378 

    Selected AceView cDNA sequences (see all 448):

    BQ775225 AA721318 AA400161 BM712490 AL120795 CB143492 CB116135 AF155095 
    BU634093 AA825580 CB306475 H84221 AI473351 AI468335 AA226615 T04966 
    BX461086 BX346894 BF792382 BF439081 CB306350 CA771960 AI027080 AI818925 

    GeneLoc Exon Structure

    Selected Alternative Splicing Database (ASD) splice patterns (SP) for YTHDF2 (see all 7)    About this scheme

    ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5 ^ 6a · 6b · 6c · 6d · 6e ^ 7 ^ 8
    SP1:        -           -     -                                   -         
    SP2:                    -     -                                             
    SP3:                                                                        
    SP4:                                                                        
    SP5:                    -     -                                             


    ECgene alternative splicing isoforms for YTHDF2

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    YTHDF2 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: TGCAGGTGTG
    YTHDF2 Expression
    About this image

    YTHDF2 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    YTHDF2 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.532286
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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for YTHDF2

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of eukaryotes.

    Orthologs for YTHDF2 gene from Selected species (see all 16)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Ythdf21 , 5 YTH domain family 21, 5 95.68(n)1
    99.65(a)1
      4 (64.92 cM)5
    2135411  NM_145393.41  NP_663368.31 
     1321849125 
    chicken
    (Gallus gallus)
    Aves YTHDF21 YTH domain family, member 2 82.86(n)
    93.01(a)
      419583  XM_003642575.2  XP_003642623.2 
    lizard
    (Anolis carolinensis)
    Reptilia YTHDF26
    YTH domain family, member 2
    92(a)
    1 ↔ 1
    GL344007.1(85722-96786)
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia ythdf21 YTH domain family, member 2 70.08(n)
    76.84(a)
      100379960  XM_004911550.1  XP_004911607.1 
    zebrafish
    (Danio rerio)
    Actinopterygii zgc562242 hypothetical protein MGC56224 80.26(n)   393220  BC047846.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta CG64226
    --
    28(a)
    1 → many
    3R(20859866-20864801)
    baker's yeast
    (Saccharomyces cerevisiae)
    Saccharomycetes --
    Putative protein of unknown function
    30(a)
    1 → many
    IV(1223474-1224394) YDR374C
    rice
    (Oryza sativa)
    Liliopsida Os.87832 Oryza sativa (japonica cultivar-group) cDNA cloneJ more 77.31(n)    AK072392.1 


    ENSEMBL Gene Tree for YTHDF2 (if available)
    TreeFam Gene Tree for YTHDF2 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for YTHDF2 gene
    YTHDF12  YTHDF32  
    4 SIMAP similar genes for YTHDF2 using alignment to 4 protein entries:     YTHD2_HUMAN (see all proteins):
    DKFZp451A052    YTHDF3    YTHDF1    DKFZp451J085

    Find genes that share paralogs with YTHDF2           About GenesLikeMe


    2 Pseudogenes.org Pseudogenes for YTHDF2
    PGOHUM00000248146 PGOHUM00000257209


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for YTHDF2 (see all 731)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 1 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1996553621,2
    --27324897(+) CCCCC-/GCCCCC 3 -- int10--------
    rs1465690761,2
    C--27331462(+) TGTTT-/TTGTTGTT 3 -- cds10--------
    rs112998641,2
    C--27336595(+) ACTTTC/-CAACT 3 -- int13Minor allele frequency- -:0.17NA CSA 6
    rs2004040631,2
    --27340286(+) TGTGT-/GTATTTTT 3 -- int10--------
    rs1460190111,2
    C--27343114(+) TATTT-/TTTTTT 3 -- int10--------
    rs106592131,2
    C--27344590(+) GTTTT-/TTGAGAG 3 -- int10--------
    rs114231181,2
    C--27346957(+) ACGCC-/CAGCTA 3 -- int10--------
    rs1137077781,2
    C--27347013(+) GGATGG/-TCTCA 3 -- int11Minor allele frequency- -:0.00CSA 2
    rs339140741,2
    C--29061384(+) CCGGC-/TTTTTT 2 -- us2k11Minor allele frequency- T:0.00NA 2
    rs350731931,2
    C--29072237(+) CCCGCC/-CCCCC 3 -- int11Minor allele frequency- -:0.00NA 2

    HapMap Linkage Disequilibrium report for YTHDF2 (29063133 - 29096287 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 3 variations for YTHDF2:    About this table    
    Variant IDTypeSubtypePubMed ID
    esv2745830CNV Deletion23290073
    nsv509080CNV Insertion20534489
    nsv160265CNV Loss16902084

    Human Gene Mutation Database (HGMD): YTHDF2
    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing YTHDF2
    DNA2.0 Custom Variant and Variant Library Synthesis for YTHDF2

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section

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    OMIM gene information: 610640    OMIM disorders: --

    2 diseases for YTHDF2:    
    About MalaCards
    acute myeloid leukemia    myeloid leukemia


    Find genes that share disorders with YTHDF2           About GenesLikeMe

    Genetic Association Database (GAD): YTHDF2
    Human Genome Epidemiology (HuGE) Navigator: YTHDF2 (1 document)

    Export disorders for YTHDF2 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for YTHDF2 gene, integrated from 10 sources (see all 42):
    (articles sorted by number of sources associating them with YTHDF2)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Antigens recognized by autologous antibody in patients with renal- cell carcinoma. (PubMed id 10508479)1, 2, 3 Scanlan M.J....Old L.J. (Int. J. Cancer 1999)
    2. N-methyladenosine-dependent regulation of messenger RNA stability. (PubMed id 24284625)1, 2 Wang X.... He C. (Nature 2014)
    3. A polymorphism of the YTHDF2 gene (1p35) located in an Alu-rich genomic domain is associated with human longevity. (PubMed id 16799135)1, 4 Cardelli M....Franceschi C. (J. Gerontol. A Biol. Sci. Med. Sci. 2006)
    4. A novel protein, Pho92, has a conserved YTH domain and regulates phosphate metabolism by decreasing the mRNA stability of PHO4 in Saccharomyces cerevisiae. (PubMed id 24206186)2 Kang H.J.... Yun C.W. (Biochem. J. 2014)
    5. Interlaboratory reproducibility of large-scale human protein-complex analysis by standardized AP-MS. (PubMed id 23455922)1 Varjosalo M....Superti-Furga G. (Nat. Methods 2013)
    6. Identification of the hypoxia-inducible factor 2I+ nuclear interactome in melanoma cells reveals master proteins involved in melanoma development. (PubMed id 23275444)1 Steunou A.L....Nieto L. (amp 2013)
    7. The protein interaction landscape of the human CMGC kinase group. (PubMed id 23602568)1 Varjosalo M....Gstaiger M. (Cell Rep 2013)
    8. Methods for quantification of in vivo changes in protein ubiquitination following proteasome and deubiquitinase inhibition. (PubMed id 22505724)1 Udeshi N.D....Carr S.A. (amp 2012)
    9. A high-throughput approach for measuring temporal changes in the interactome. (PubMed id 22863883)1 Kristensen A.R....Foster L.J. (Nat. Methods 2012)
    10. Systems-wide analysis of ubiquitylation dynamics reveals a key role for PAF15 ubiquitylation in DNA-damage bypass. (PubMed id 23000965)1 Povlsen L.K....Choudhary C. (Nat. Cell Biol. 2012)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section

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    Entrez Gene: 51441 HGNC: 31675 AceView: YTHDF2 Ensembl:ENSG00000198492 euGenes: HUgn51441
    ECgene: YTHDF2 H-InvDB: YTHDF2

    (According to HUGE)
    About This Section

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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
    About This Section

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    NameDescription
    PharmGKB entry for YTHDF2 Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for YTHDF2 Genetics and Cytogenetics in Oncology and Haematology

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section

    TryGeneCards Plus
    Patent Information for YTHDF2 gene:
    Search GeneIP for patents involving YTHDF2

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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