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YTHDF2 Gene

protein-coding   GIFtS: 54

GC01P028935
YTH domain family, member 2
(Previous name: YTH domain family 2 )
Symbol approved by the HUGO Gene Nomenclature Committee (HGNC) database
Services    
(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc , and/or 7Ensembl, 8miRBase)
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Aliases
9430020E02Rik 2
HGRG8 1, 2, 3
NY-REN-2 1, 2
OTTHUMP00000003782 2
Descriptions
CLL-associated antigen KW-14 3
High-glucose-regulated protein 8 2, 3
Renal carcinoma antigen NY-REN-2 3
YTH domain family 2 1, 2
YTH domain family, member 2 2
high glucose-regulated protein 8 2
External Ids
HGNC: 316751
Entrez Gene: 514412
UniProtKB: Q9Y5A93
Ensembl: ENSG000001984927
Search outside databases for aliases for YTHDF2 gene

Previous GC identifers: GC01P028751 GC01P028884

(According to Entrez Gene, Wikipedia's Gene Wiki,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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  --
(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 36),
and/or miRBase,
Genomic Views according to UCSC and Ensembl, Transcription factor binding sites according to SABiosciences)
About This Section

Genomic View:
UCSC Golden Path with GeneCards custom track

 Transcription factor binding sites upstream to the YTHDF2 gene  

Entrez Gene cytogenetic band: 1p35   Ensembl cytogenetic band:  1p35.3   HGNC cytogenetic band: 1p35

YTHDF2 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)

GeneLoc gene densities for chromosome 1         GeneLoc Exon Structure

GeneLoc location for GC01P028935:     (about GC identifiers)

Start:
28,935,723 bp from pter
End:
28,968,874 bp from pter
Size:
33,152 bases
Orientation:
plus strand
RefSeq DNA sequence:
NC_000001.9  NT_004610.18  
(According to 1UniProtKB, and/or Ensembl, Phosphorylation sites according to 2Phosphosite, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Enzo Life Sciences, Abnova, OriGene and/or, Abcam,
Biochemical Assays by Invitrogen, Millipore, R&D Systems, Cell Signaling Technology, and/or Enzo Life Sciences, Ontologies according to Gene Ontology Consortium 01 Apr 2009 and Entrez Gene, Antibodies by Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Cell Signaling Technology, Abcam, Abnova, and/or Novus Biologicals)
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UniProtKB/Swiss-Prot: YTHD2_HUMAN, Q9Y5A9 (See protein sequence)
Recommended Name: YTH domain family protein 2  
Size: 579 amino acids; 62334 Da
Sequence caution: Sequence=AAD42861.1; Type=Frameshift; Positions=565; Sequence=AAF08813.1;
Type=Frameshift; Positions=565;
Secondary accessions: A6NKG4 B4E1G7 Q5VSZ9 Q8TDH0 Q9BUJ5
Alternative splicing: 2 isoforms:  Q9Y5A9-1   Q9Y5A9-2   

Post-translational modifications:

  • View phosphorylation sites using PhosphoSite2


  • REFSEQ proteins: NP_057342.2  

    ENSEMBL proteins: 
    ENSP00000333525 ENSP00000383854 ENSP00000362918 


    Human Recombinant Proteins 
    Browse Drug Discovery Central at Invitrogen for human recombinant proteins
    Browse Purified and Recombinant Proteins at Millipore
    Browse Human Recombinant Proteins at Sigma-Aldrich  
    Browse R&D Systems for human recombinant proteins
    Browse recombinant and purified proteins available from Enzo Life Sciences
    Browse Abcam for Recombinant Proteins
    Human Recombinant Proteins from Abnova (YTHDF2)
                    Browse Origene for full length recombinant human proteins expressed in human HEK293 cells 


    Antibodies for YTHDF2: 
    Browse Antibodies Central at Invitrogen
    Browse Millipore's Extensive Line of Mono- and Polyclonal Antibodies
    Sigma-Aldrich Antibodies for YTHDF2
    Browse R&D Systems for Antibodies
    Search for antibodies at Abcam and the World's Antibody Gateway (free search engine of over 150 antibody companies)
    Monoclonal and Polyclonal Antibodies from Abnova (YTHDF2)
    Novus Biologicals Antibody for YTHDF2

    Assays for YTHDF2: 
    Browse Invitrogen for biochemical assays
    Browse Kits and Assays available from Millipore
    Browse R&D Systems for biochemical assays
    Browse biochemical assays available from Enzo Life Sciences

    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section

    1 InterPro domain/family:
     IPR007275 YTH


       GeneDecks  YTHDF2 for the domains selected above  
    About GeneDecksing

    Graphical View of Domain Structure for InterPro Entry Q9Y5A9

    ProtoNet protein and cluster: Q9Y5A9

    1 Blocks protein family: IPB007275 YT521-B-like protein

    UniProtKB/Swiss-Prot: YTHD2_HUMAN, Q9Y5A9
    Similarity: Contains 1 YTH domain

    (According to MGI Jun 06 2009, UniProtKB, IUBMB,and/or Genatlas,
    shRNA from OriGene, Sigma-Aldrich, RNAi from Sigma-Aldrich,
    RNAi Products, Clones, and Q-PCR Products from Invitrogen, Millipore, OriGene, and/or Abnova, siRNAs from Applied Biosystems, SYBR primers from OriGene, Cell-based Assays from Millipore, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
    About This Section

    Inhib.
    RNA:
    Invitrogen RNAi Products for gene knock-down (YTHDF2)
    Browse for Gene Knock-down Tools from Millipore
    Browse Abnova for Chimera RNAi Products
                  OriGene 29mer shRNA kit in GFP-retroviral vector: NM_016258

                  Applied Biosystems Silencer® siRNAs for YTHDF2

                  Sigma-Aldrich siRNA for YTHDF2  
                         Browse shRNA at Sigma-Aldrich  
                         Explore Sigma-Aldrich super-pooled esiRNAs  

    Clones:Invitrogen Clones for YTHDF2
    Browse Clones for the Expression of Recombinant Proteins Available from Millipore
                  OriGene GFP tagged cDNA clone in CMV expression vector: NM_016258
                                     Myc/DDK tagged cDNA clone in CMV expression vector: NM_016258
                                     untagged cDNA clones in CMV expression vector (see all 2): NM_016258 

    Primers: Browse Quantitative PCR Central at Invitrogen for Q-PCR LUX™ Primers
                  OriGene genome-wide validated SYBR primer pairs: NM_016258

    (Pathways according to Invitrogen (maps by GeneGo), Millipore, Cell Signaling Technology, Sigma-Aldrich, KEGG and/or UniProtKB,
    Sets of similar genes according to GeneDecks, Proteins Network according to SABiosciences, Interactions according to 1UniProtKB, 2MINT, and/or 3STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
    About This Section



    3 Interacting proteins for YTHDF2 (ENSP000003629183) via UniProtKB, MINT, and/or STRING
    InteractantInteraction Details
    GeneCardExternal ID(s)
    ZNF687ENSP000003198293STRING (score=.892)
    SH3D19ENSP000003029133STRING (score=.886)
    RUNX1ENSP000003003053STRING (score=.798)
    About this table

    1 Gene Ontology (GO) biological process term (links to tree view):

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006959 humoral immune response TAS10508479
    About this table
    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, Sigma-Aldrich, Tocris Bioscience, and/or Novoseek and Drugs according to Enzo Life Sciences and/or PharmGKB)
    About This Section

    Browse drugs & compounds from Enzo Life Sciences
    Browse Small Molecules at Sigma-Aldrich

    Browse Tocris compounds for YTHDF2

    (GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 219 Homo sapiens; Jun 2 2009) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView,
    non coding RNAs according to RNAdb,
    ESTs according to GeneTide,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from Invitrogen, Millipore, and/or Abnova,
    siRNAs from Applied Biosystems, Sigma-Aldrich,
    shRNA from Sigma-Aldrich, OriGene,
    Tagged/untagged cDNA clones from OriGene,
    Expression Assays from Applied Biosystems)
    About This Section

    Inhib.
    RNA:
    Invitrogen RNAi Products for gene knock-down (YTHDF2)
    Browse for Gene Knock-down Tools from Millipore
    Browse Abnova for Chimera RNAi Products
                  OriGene 29mer shRNA kit in GFP-retroviral vector: NM_016258

                  Sigma-Aldrich siRNA for YTHDF2  
                         Browse shRNA at Sigma-Aldrich  
                         Explore Sigma-Aldrich super-pooled esiRNAs  

    Applied Biosystems Silencer® siRNAs: 

    NM_016258  

    REFSEQ mRNAs for YTHDF2 gene: 

    NM_016258.2   

    Applied Biosystems TaqMan ® Gene Expression Assays: 

    NM_016258  

                  OriGene GFP tagged cDNA clone in CMV expression vector: NM_016258
                                     Myc/DDK tagged cDNA clone in CMV expression vector: NM_016258
                                     untagged cDNA clones in CMV expression vector (see all 2): NM_016258 

    Additional cDNA sequence: 

    AB451335.1 AB451484.1 AF155095.1 AF192968.1 AK074276.1 AK292581.1 AK303833.1 BC002559.2 
    CR593745.1 CR594279.1 CR595878.1 CR599207.1 EU093085.2 

    24 DOTS entries:

    DT.448634  DT.202769  DT.95166815  DT.100884786  DT.100884782  DT.120759786  DT.100884776  DT.100884781 
    DT.120759785  DT.121431552  DT.97847970  DT.121431566  DT.99971591  DT.100884785  DT.101964561  DT.121431544 
    DT.121431549  DT.95166788  DT.95166857  DT.97777074  DT.100721532  DT.121431538  DT.40296836  DT.91812378 

    24/448 AceView cDNA sequences (see all 448 ):

    AW189393 AA278174 BX442178 CR593745 BQ642076 BX461086 CA443459 AA729840 
    AI500186 AI492914 AI434380 BP345358 CB306211 CB160717 BQ946104 BU155230 
    BM989398 BF439081 BC002559 AI627674 AI473351 AA400161 AI590324 BU538179 

    highest scoring ESTs for YTHDF2:

    AI561100 AA083725 AA100514 AA112006 AA128950 AA158158 AA165364 AA218977 AA223209 AA223343 

    Unigene Cluster for YTHDF2:

    YTH domain family, member 2
    Hs.532286  [show with all ESTs]
    Unigene Representative Sequence: NM_016258


    GeneLoc Exon Structure

    5/7 Alternative Splicing Database (ASD) splice patterns (SP) for YTHDF2 (see all 7 )

    ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5 ^ 6a · 6b · 6c · 6d · 6e ^ 7 ^ 8
    SP1:        -           -     -                                   -         
    SP2:                    -     -                                             
    SP3:                                                                        
    SP4:                                                                        
    SP5:                    -     -                                             

    About this scheme

    ECgene alternative splicing isoforms for YTHDF2

    3 Ensembl transcripts including schematic representations:
    ENST00000331716  ENST00000401077  ENST00000373812  
    (Experimental results according to 1GeneNote and GNF BioGPS,
    probe sets-to-genes annotations according to 2GeneAnnot , 3GeneTide , Sets of similar genes according to GeneDecks, Electronic Northern calculations according to data from UniGene (Build 219 Homo sapiens), SAGE tags according to CGAP, plus additional links to SOURCE, and/or GNF BioGPS, and/or EXPOLDB, and/or UniProtKB,
    Expression Assays from Applied Biosystems )
    About This Section

    YTHDF2 expression in normal and diseased human tissues

     Applied Biosystems TaqMan ® Gene Expression Assays for YTHDF2

    1 / 2 / 3

    5 probe-sets matching YTHDF2 gene


    Affymetrix
    probe-set
    Array  GeneAnnot data GeneNote data GeneTide data
    # genes Sensitivity Specificity Correlation Length Gb_Accession Consensus Uniqueness Score Rank

    65763_at2, 3 U95-C 1 1.00 1.00 1.00 1.00 AI561100 1.00 1.00 1.00 1

    217812_at2, 3 U133-A 1 1.00 1.00 -- -- NM_016258 0.60 1.00 0.82 1

    222430_s_at2, 3 U133-B 2 1.00 0.68 -- -- BC002559 0.80 1.00 0.91 1

    217812_at2 U133Plus2 1 1.00 1.00 -- -- -- -- -- -- --

    222430_s_at2 U133Plus2 2 1.00 0.68 -- -- -- -- -- -- --
    About this table
    Data from (Publications) and GNF BioGPS
        About these images
    About these images

    CGAP SAGE TAG: TGCAGGTGTG

    SOURCE GeneReport for Unigene cluster: Hs.532286
    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD and/or 5MGI Jun 06 2009, with possible further links to Flybase and/or WormBase, Gene Trees according to Ensembl)
    About This Section


    Orthologs for YTHDF2 gene from 5/8 species (see all 8 )
    Organism Gene Locus Description Human
    Similarity
    NCBI accessions
    dog
    (Canis familiaris)
    YTHDF21   -- YTH domain family, member 2 95.78(n)
    97.75(a)
    478161  XM_535336.2  XP_535336.2 
    chimpanzee
    (Pan troglodytes)
    YTHDF21   -- YTH domain family, member 2 99.94(n)
    100(a)
    740305  XM_001154131.1  XP_001154131.1 
    cow
    (Bos taurus)
    YTHDF21   -- YTH domain family, member 2 97.24(n)
    99.65(a)
    541050  NM_001076253.1  NP_001069721.1 
    rat
    (Rattus norvegicus)
    Ythdf21   -- YTH domain family, member 2 95.03(n)
    99.22(a)
    313053  XM_232772.4  XP_232772.4 
    mouse
    (Mus musculus)
    Ythdf21, 5 45
    YTH domain family 21, 5 95.62(n)1
    99.48(a)1
    2135411  NM_145393.31  NP_663368.21 
     AI4507655  AK0316165  (see all 22)
    About this table        Species with no ortholog for YTHDF2

    ENSEMBL Gene Tree for YTHDF2
    (Paralogs according to 1HomoloGene
    and 2Ensembl, Pseudogenes according to 3Pseudogene.org)
    About This Section

    Paralogs for YTHDF2 gene
    YTHDF12  YTHDF32  

    (According to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, and UniProtKB, Linkage Disequilibrium by HapMap, Genotyping Reagents from Applied Biosystems)
    About This Section


    10/195 NCBI SNPs in YTHDF2 are shown (see all 195 )
    (Click for Applied Biosystems TaqMan ® Genotyping Assay)  (see all 44)
    ABGenomic DataTranscription DataAllele Frequencies
    SNP IDValidChr 1 posSequenceRecsAA
    Chg
    TypeMoreRecsAllele
    freq
    PopTotal
    sample
    More
    ------------
    rs37536921,2
    A,C,F,H28935400(-) ATTGCC/AGGAAG 1 -- ng51 trp313Minor allele frequency- A:0.41NA MN EA EU WA 2226
    rs37380671,2
    A,C,F,H28935823(-) GAAGCT/CGTGCT 1 -- ut516Minor allele frequency- C:0.41MN EA EU WA 1670
    --
    rs168383821,2
    C,F,H28942019(+) CATTAC/GTAGTA 1 T/S mis1 ese311Minor allele frequency- G:0.01NA EU EA WA 980
    rs172622931,2
    C,F,H28935014(+) ACAGAG/ATCTCG 1 -- ng517Minor allele frequency- A:0.04NA EU EA WA 562
    rs66975401,2
    C,F,H28936146(+) CGCAGC/ACGGGG 1 -- ut51 ese34Minor allele frequency- A:0.03EU EA WA 418
    rs120680751,2
    C,F,H28935307(+) TGCATG/AAGGTG 1 -- ng517Minor allele frequency- A:0.08EU EA WA NA 562
    rs13180001,2
    F,H28935764(+) CTGGTC/AGTCCC 1 -- ut517Minor allele frequency- A:0.00MN EU EA WA NA 780
    --
    rs352887451,2
    F28942729(-) AACGGG/AGCCTT 1 S/P mis11Minor allele frequency- A:0.46NA 24
    --
    rs23187701,2
    H28942219(+) GTCCCG/ATTGCA 1 I/V mis1 ese34Minor allele frequency- A:0.00EU EA WA 420
    rs343052381,2
    F28934205(+) CAACCG/ACTTAC 1 -- ng511Minor allele frequency- A:0.02NA 92
    About this table

    HapMap Linkage Disequilibrium images for YTHDF2 (up to first 250kb)

    (in which this Gene is Involved, According to OMIM, UniProtKB, PharmGKB, Genatlas, GeneTests, Blood group antigen gene mutations by BGMUT, HGMD, GAD, HuGE Navigator, BCGD, and/or TGDB.)
    About This Section

    OMIM: 610640   disorders: 152430  

    Human Gene Mutation Database: YTHDF2
    Human Genome Epidemiology Navigator: YTHDF2 (1 document)

    (Possibly Related Articles in Doctor's Guide)
    About This Section

      --

    (in PubMed. Associations of this gene to articles via 1Novoseek, 2HGNC, 3Entrez Gene, 4UniProtKB/Swiss-Prot, 5UniProtKB/TrEMBL, 6GAD, and/or 7PharmGKB)
    About This Section

    10/11 PubMed articles for YTHDF2 gene (see all 11 ):
    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section

     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)
    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, and/or H-InvDB)
    About This Section

    Entrez Gene: 51441 HGNC: 31675 AceView: YTHDF2 Ensembl:ENSG00000198492 euGenes: HUgn51441
    ECgene: YTHDF2 H-InvDB: YTHDF2
    (According to HUGE)
    About This Section

      --
    (According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section

    NameDescription
    ATLAS Chromosomes in Cancer entry for YTHDF2 Genetics and Cytogenetics in Oncology and Haematology
    (Available from WIS Yeda, Salk, Tufts)
    About This Section

      --
    (Reagents available from Applied Biosystems, Antibodies and assays by Cell Signaling Technology, Abcam, Novus Biologicals,
    Sigma-Aldrich, R&D Systems, Millipore, Abnova, and/or Invitrogen, Clones available from OriGene,and/or Invitrogen, Drugs and/or compounds by Sigma-Aldrich,
    Enzo Life Sciences, and/or Tocris Bioscience)
    About This Section



    Products for YTHDF2:
     TaqMan ® Gene Expression Assays
     TaqMan ® Genotyping Assays
      Free SNP selection tool



      Invitrogen iPath Pathways  Invitrogen BLOCK-iT™ RNAi
      Invitrogen Antibodies  Invitrogen Assays
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      Invitrogen Proteins / Assays / Screening Services  Search Invitrogen catalog for YTHDF2-related products

     Millipore Custom Antibody & Bulk Services
     Millipore Preclinical / Clinical Development Services
     Millipore Immunoassay Services
     Millipore Target Screening & Profiling Services


     Predesigned and custom siRNAs for YTHDF2 Antibodies for YTHDF2
     Explore super-pooled esiRNAs Browse proteins at Sigma-Aldrich
     Browse shRNAs at Sigma-Aldrich Browse small molecules at Sigma-Aldrich
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