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Aliases for YTHDF1 Gene

Aliases for YTHDF1 Gene

  • YTH N(6)-Methyladenosine RNA Binding Protein 1 2 3
  • Dermatomyositis Associated With Cancer Putative Autoantigen 1 3 4
  • YTH Domain Family, Member 1 2 3
  • YTH Domain Family 1 2 3
  • C20orf21 3 4
  • DACA-1 3 4
  • YTH Domain-Containing Family Protein 1 3
  • YTH Domain Family Protein 1 3

External Ids for YTHDF1 Gene

Previous HGNC Symbols for YTHDF1 Gene

  • C20orf21

Previous GeneCards Identifiers for YTHDF1 Gene

  • GC20M062554
  • GC20M061297
  • GC20M061826
  • GC20M058551

Summaries for YTHDF1 Gene

GeneCards Summary for YTHDF1 Gene

YTHDF1 (YTH N(6)-Methyladenosine RNA Binding Protein 1) is a Protein Coding gene. Diseases associated with YTHDF1 include dermatomyositis. An important paralog of this gene is YTHDF3.

UniProtKB/Swiss-Prot for YTHDF1 Gene

  • Specifically recognizes and binds N6-methyladenosine (m6A)-containing RNAs. M6A is a modification present at internal sites of mRNAs and some non-coding RNAs and plays a role in the efficiency of mRNA splicing, processing and stability.

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for YTHDF1 Gene

Genomics for YTHDF1 Gene

Regulatory Elements for YTHDF1 Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for YTHDF1 Gene

63,195,429 bp from pter
63,216,234 bp from pter
20,806 bases
Minus strand

Genomic View for YTHDF1 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for YTHDF1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for YTHDF1 Gene

Proteins for YTHDF1 Gene

  • Protein details for YTHDF1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    YTH domain-containing family protein 1
    Protein Accession:
    Secondary Accessions:
    • Q8N3G5
    • Q8TBT1
    • Q96AN4
    • Q96S57
    • Q9BTI7
    • Q9NX79

    Protein attributes for YTHDF1 Gene

    559 amino acids
    Molecular mass:
    60874 Da
    Quaternary structure:
    No Data Available

    Three dimensional structures from OCA and Proteopedia for YTHDF1 Gene

    Alternative splice isoforms for YTHDF1 Gene


neXtProt entry for YTHDF1 Gene

Proteomics data for YTHDF1 Gene at MOPED

Post-translational modifications for YTHDF1 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for YTHDF1 Gene

ENSEMBL proteins:
REFSEQ proteins:

Antibody Products

  • Santa Cruz Biotechnology (SCBT) Antibodies for YTHDF1

No data available for DME Specific Peptides for YTHDF1 Gene

Domains for YTHDF1 Gene

Protein Domains for YTHDF1 Gene


Suggested Antigen Peptide Sequences for YTHDF1 Gene

Graphical View of Domain Structure for InterPro Entry



  • Contains 1 YTH domain.
  • Contains 1 YTH domain.
genes like me logo Genes that share domains with YTHDF1: view

No data available for Gene Families for YTHDF1 Gene

Function for YTHDF1 Gene

Molecular function for YTHDF1 Gene

UniProtKB/Swiss-Prot Function:
Specifically recognizes and binds N6-methyladenosine (m6A)-containing RNAs. M6A is a modification present at internal sites of mRNAs and some non-coding RNAs and plays a role in the efficiency of mRNA splicing, processing and stability.

Gene Ontology (GO) - Molecular Function for YTHDF1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0044822 poly(A) RNA binding IDA 22658674
GO:1990247 N6-methyladenosine-containing RNA binding IDA 24284625
genes like me logo Genes that share ontologies with YTHDF1: view

Phenotypes for YTHDF1 Gene

GenomeRNAi human phenotypes for YTHDF1:
genes like me logo Genes that share phenotypes with YTHDF1: view

Animal Model Products

miRNA for YTHDF1 Gene

miRTarBase miRNAs that target YTHDF1

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for YTHDF1

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targeting and HOMER Transcription for YTHDF1 Gene

Localization for YTHDF1 Gene

Subcellular locations from

Jensen Localization Image for YTHDF1 Gene COMPARTMENTS Subcellular localization image for YTHDF1 gene
Compartment Confidence
cytosol 2
nucleus 2

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Gene Ontology (GO) - Cellular Components for YTHDF1 Gene

Pathways for YTHDF1 Gene

SuperPathways for YTHDF1 Gene

No Data Available

Gene Ontology (GO) - Biological Process for YTHDF1 Gene


No data available for Pathways by source for YTHDF1 Gene

Transcripts for YTHDF1 Gene

mRNA/cDNA for YTHDF1 Gene

Unigene Clusters for YTHDF1 Gene

YTH domain family, member 1:
Representative Sequences:

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for YTHDF1

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for YTHDF1 Gene

No ASD Table

Relevant External Links for YTHDF1 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for YTHDF1 Gene

mRNA expression in normal human tissues for YTHDF1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues for YTHDF1 Gene

This gene is overexpressed in Lung (30.0) and Breast (18.4).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for YTHDF1 Gene

SOURCE GeneReport for Unigene cluster for YTHDF1 Gene Hs.744852

genes like me logo Genes that share expressions with YTHDF1: view

Expression partners for YTHDF1 Gene

* - Elite partner

Primer Products

In Situ Assay Products

No data available for mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for YTHDF1 Gene

Orthologs for YTHDF1 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for YTHDF1 Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia YTHDF1 35
  • 84.62 (n)
  • 88.73 (a)
  • 88 (a)
(Canis familiaris)
Mammalia YTHDF1 35
  • 88.25 (n)
  • 92.72 (a)
  • 93 (a)
(Mus musculus)
Mammalia Ythdf1 35
  • 88.07 (n)
  • 93.92 (a)
Ythdf1 16
Ythdf1 36
  • 94 (a)
(Pan troglodytes)
Mammalia YTHDF1 35
  • 98.51 (n)
  • 98.39 (a)
  • 100 (a)
(Rattus norvegicus)
Mammalia Ythdf1 35
  • 88.07 (n)
  • 93.74 (a)
(Monodelphis domestica)
Mammalia YTHDF1 36
  • 89 (a)
(Ornithorhynchus anatinus)
Mammalia YTHDF1 36
  • 89 (a)
(Gallus gallus)
Aves YTHDF1 35
  • 80.38 (n)
  • 89.45 (a)
  • 89 (a)
(Anolis carolinensis)
Reptilia YTHDF1 36
  • 86 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia MGC75606 35
ythdf1 35
  • 78.25 (n)
  • 84.66 (a)
African clawed frog
(Xenopus laevis)
Amphibia MGC68505 35
(Danio rerio)
Actinopterygii ythdf1 35
  • 72.74 (n)
  • 78.45 (a)
ythdf1 36
  • 70 (a)
fruit fly
(Drosophila melanogaster)
Insecta CG6422 36
  • 27 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes -- 36
  • 28 (a)
(Oryza sativa)
Liliopsida Os.7188 35
(Triticum aestivum)
Liliopsida Ta.7012 35
(Zea mays)
Liliopsida Zm.13185 35
sea squirt
(Ciona savignyi)
Ascidiacea CSA.6332 36
  • 42 (a)
Species with no ortholog for YTHDF1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • worm (Caenorhabditis elegans)

Evolution for YTHDF1 Gene

Gene Tree for YTHDF1 (if available)
Gene Tree for YTHDF1 (if available)

Paralogs for YTHDF1 Gene

Paralogs for YTHDF1 Gene

(4) SIMAP similar genes for YTHDF1 Gene using alignment to 4 proteins: Pseudogenes for YTHDF1 Gene

genes like me logo Genes that share paralogs with YTHDF1: view

Variants for YTHDF1 Gene

Sequence variations from dbSNP and Humsavar for YTHDF1 Gene

SNP ID Clin Chr 20 pos Sequence Context AA Info Type MAF
rs1044505 -- 63,196,383(-) TATTC(G/T)GTGAG utr-variant-3-prime
rs3787510 -- 63,199,415(-) CAGCC(C/T)CCCGG intron-variant
rs3787511 -- 63,198,781(-) CACTT(C/T)GACCT intron-variant
rs4809503 -- 63,209,526(+) gccct(C/T)tggga intron-variant
rs4809504 -- 63,211,495(+) ATATG(C/T)CCACT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for YTHDF1 Gene

Variant ID Type Subtype PubMed ID
nsv913073 CNV Loss 21882294
nsv9825 CNV Gain 18304495
dgv4618n71 CNV Loss 21882294
nsv913161 CNV Loss 21882294
dgv68n68 CNV Loss 17160897
nsv913165 CNV Loss 21882294
nsv913166 CNV Loss 21882294
nsv834031 CNV Loss 17160897
dgv519n27 CNV Loss 19166990
dgv4626n71 CNV Loss 21882294
dgv4627n71 CNV Loss 21882294
nsv828798 CNV Loss 20364138
esv2722892 CNV Deletion 23290073
nsv527884 CNV Loss 19592680
dgv4628n71 CNV Loss 21882294
dgv4629n71 CNV Loss 21882294
nsv834032 CNV Loss 17160897

Relevant External Links for YTHDF1 Gene

HapMap Linkage Disequilibrium report

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for YTHDF1 Gene

Disorders for YTHDF1 Gene

MalaCards: The human disease database

MalaCards: The human disease database.

Search for YTHDF1 Gene in MalaCards »

(1) Disease for YTHDF1 Gene

genes like me logo Genes that share disorders with YTHDF1: view

No data available for OMIM , UniProtKB/Swiss-Prot , University of Copenhagen DISEASES , Novoseek inferred disease relationships , Genatlas and External Links for YTHDF1 Gene

Publications for YTHDF1 Gene

  1. N-methyladenosine-dependent regulation of messenger RNA stability. (PMID: 24284625) Wang X. … He C. (Nature 2014) 2 3 4
  2. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4
  4. The DNA sequence and comparative analysis of human chromosome 20. (PMID: 11780052) Deloukas P. … Rogers J. (Nature 2001) 3 4
  5. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg R.L. … Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002) 3

Products for YTHDF1 Gene

Sources for YTHDF1 Gene

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