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YTHDF1 Gene

protein-coding GIFtS: 46

GC20M061297

YTH domain family, member 1
(Previous name: YTH domain family 1 )
Symbol approved by the HUGO Gene Nomenclature Committee (HGNC) database
(Previous symbol: C20orf21)

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc , and/or ⁷Ensembl, ⁸miRBase)
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Aliases
C20orf21 ^², ³
DACA-1 ^³
FLJ20391 ^¹, ²
OTTHUMP00000031533 ^²

Descriptions
Dermatomyositis associated with cancer putative autoantigen 1 ^³
YTH domain family 1 ^¹, ²
YTH domain family, member 1 ^²

External Ids
HGNC: 15867¹
Entrez Gene: 54915²
UniProtKB: Q9BYJ9³
Ensembl: ENSG00000149658⁷

Search outside databases for aliases for YTHDF1 gene

Previous GC identifer: GC20M062554

(According to Entrez Gene, Wikipedia's Gene Wiki,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 36),
and/or miRBase,
Genomic Views according to UCSC and Ensembl, Transcription factor binding sites according to SABiosciences)
About This Section

Genomic View:

UCSC Golden Path with GeneCards custom track

Transcription factor binding sites upstream to the YTHDF1 gene

Entrez Gene cytogenetic band: 20q13.33 Ensembl cytogenetic band: 20q13.33 HGNC cytogenetic band: 20q13.33

YTHDF1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)

GeneLoc gene densities for chromosome 20 GeneLoc Exon Structure

GeneLoc location for GC20M061297: (about GC identifiers)

Start:	61,297,226 bp from pter
End:	61,318,031 bp from pter
Size:	20,806 bases
Orientation:	minus strand

RefSeq DNA sequence:

NC_000020.9 NT_011333.5

(According to ¹UniProtKB, and/or Ensembl, Phosphorylation sites according to ²Phosphosite, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Enzo Life Sciences, Abnova, OriGene and/or, Abcam,
Biochemical Assays by Invitrogen, Millipore, R&D Systems, Cell Signaling Technology, and/or Enzo Life Sciences, Ontologies according to Gene Ontology Consortium 01 Apr 2009 and Entrez Gene, Antibodies by Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Cell Signaling Technology, Abcam, Abnova, and/or Novus Biologicals)
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UniProtKB/Swiss-Prot: YTHD1_HUMAN, Q9BYJ9 (See protein sequence)

Recommended Name: YTH domain family protein 1

Size: 559 amino acids; 60874 Da

Secondary accessions: Q8N3G5 Q8TBT1 Q96AN4 Q96S57 Q9BTI7 Q9NX79

Alternative splicing: 2 isoforms: Q9BYJ9-1 Q9BYJ9-2

Post-translational modifications:

View phosphorylation sites using PhosphoSite²

REFSEQ proteins: NP_060268.2

ENSEMBL proteins:

ENSP00000359364 ENSP00000359359 ENSP00000339489 ENSP00000359358

Human Recombinant Proteins

	Browse Drug Discovery Central at Invitrogen for human recombinant proteins
	Browse Purified and Recombinant Proteins at Millipore
	Browse Human Recombinant Proteins at Sigma-Aldrich
	Browse R&D Systems for human recombinant proteins
	Browse recombinant and purified proteins available from Enzo Life Sciences
	Recombinant Proteins from Abcam (YTHD1)
	Human Recombinant Proteins from Abnova (YTHDF1)

OriGene Purified Recombinant Human Protein: YTHDF1

Antibodies for YTHDF1:

	Browse Antibodies Central at Invitrogen
	Browse Millipore's Extensive Line of Mono- and Polyclonal Antibodies
	Browse Antibodies at Sigma-Aldrich
	Browse R&D Systems for Antibodies
	Antibodies from Abcam (YTHD1), each with their Abpromise^SM
	Browse Abnova for Monoclonal and Polyclonal Antibodies
	Search Novus for antibodies for YTHDF1

Assays for YTHDF1:

	Browse Invitrogen for biochemical assays
	Browse Kits and Assays available from Millipore
	Browse R&D Systems for biochemical assays
	Browse biochemical assays available from Enzo Life Sciences

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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Graphical View of Domain Structure for InterPro Entry Q9BYJ9

ProtoNet protein and cluster: Q9BYJ9

1 Blocks protein family: IPB007275 YT521-B-like protein

UniProtKB/Swiss-Prot: YTHD1_HUMAN, Q9BYJ9

Similarity: Contains 1 YTH domain

(According to MGI Jun 06 2009, UniProtKB, IUBMB,and/or Genatlas,
shRNA from OriGene, Sigma-Aldrich, RNAi from Sigma-Aldrich,
RNAi Products, Clones, and Q-PCR Products from Invitrogen, Millipore, OriGene, and/or Abnova, siRNAs from Applied Biosystems, SYBR primers from OriGene, Cell-based Assays from Millipore, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
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Inhib. RNA:		Invitrogen RNAi Products for gene knock-down (YTHDF1)
		Browse for Gene Knock-down Tools from Millipore
		Browse Abnova for Chimera RNAi Products

OriGene 29mer shRNA kit in GFP-retroviral vector: NM_017798

Applied Biosystems Silencer® siRNAs for YTHDF1

Sigma-Aldrich siRNA for YTHDF1

Sigma-Aldrich shRNA for YTHDF1

Explore Sigma-Aldrich super-pooled esiRNAs

Clones:		Invitrogen Clones for YTHDF1
		Browse Clones for the Expression of Recombinant Proteins Available from Millipore

OriGene GFP tagged cDNA clone in CMV expression vector: NM_017798
Myc/DDK tagged cDNA clone in CMV expression vector: NM_017798
untagged cDNA clones in CMV expression vector (see all 2): AK095795

Primers:

Browse Quantitative PCR Central at Invitrogen for Q-PCR LUX™ Primers

OriGene genome-wide validated SYBR primer pairs: NM_017798

1 MGI phenotypic allele

for Ythdf1 (no phenotypes)

(Pathways according to Invitrogen (maps by GeneGo), Millipore, Cell Signaling Technology, Sigma-Aldrich, KEGG and/or UniProtKB,
Sets of similar genes according to GeneDecks, Proteins Network according to SABiosciences, Interactions according to ¹UniProtKB, ²MINT, and/or ³STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
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(Chemical Compounds according to UniProtKB, Enzo Life Sciences, Sigma-Aldrich, Tocris Bioscience, and/or Novoseek and Drugs according to Enzo Life Sciences and/or PharmGKB)
About This Section

Browse drugs & compounds from Enzo Life Sciences

Browse Small Molecules at Sigma-Aldrich

Browse Tocris compounds for YTHDF1

(GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 219 Homo sapiens; Jun 2 2009) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView,
non coding RNAs according to RNAdb,
ESTs according to GeneTide,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from Invitrogen, Millipore, and/or Abnova,
siRNAs from Applied Biosystems, Sigma-Aldrich,
shRNA from Sigma-Aldrich, OriGene,
Tagged/untagged cDNA clones from OriGene,
Expression Assays from Applied Biosystems)
About This Section

Inhib. RNA:		Invitrogen RNAi Products for gene knock-down (YTHDF1)
		Browse for Gene Knock-down Tools from Millipore
		Browse Abnova for Chimera RNAi Products

OriGene 29mer shRNA kit in GFP-retroviral vector: NM_017798

Sigma-Aldrich siRNA for YTHDF1

Sigma-Aldrich shRNA for YTHDF1

Explore Sigma-Aldrich super-pooled esiRNAs

Applied Biosystems Silencer® siRNAs:

NM_017798

REFSEQ mRNAs for YTHDF1 gene:

NM_017798.3

Applied Biosystems TaqMan ® Gene Expression Assays:

NM_017798

              OriGene GFP tagged cDNA clone in CMV expression vector: NM_017798
                                 Myc/DDK tagged cDNA clone in CMV expression vector: NM_017798
                                 untagged cDNA clones in CMV expression vector (see all 2): AK095795

Additional cDNA sequence:

AB055518.1 AK000398.1 AK024546.1 AK095795.1 AK300073.1 AL834366.1 BC003681.1 BC016920.2

BC025264.1 BC050284.1 CR594400.1

9 DOTS entries:

DT.91802563 DT.95289733 DT.120833622 DT.102831513 DT.95289731 DT.95289734 DT.99994499 DT.100027658

DT.95289732

24/237 AceView cDNA sequences (see all 237 ):

AI421444 AL550164 CD673219 AV729447 AV729585 AI207174 BM194314 BM745209

AI421386 AA405564 AI553931 BF818964 BF196729 CR594400 CA311646 BM743244

CB529952 AW075266 NM_017798 AA301454 AW769250 AB055518 AV725141 AI078340

highest scoring ESTs for YTHDF1:

AK095795 AL514504 AL526609 AW001012 BC050284 BI562443 CB960283 CB961972 CB988619 AA099708

Unigene Cluster for YTHDF1:

YTH domain family, member 1

Hs.11747 [show with all ESTs]

Unigene Representative Sequence: NM_017798

GeneLoc Exon Structure

4 Ensembl transcripts including schematic representations:

ENST00000370339 ENST00000370334 ENST00000342761 ENST00000370333

(Experimental results according to ¹GeneNote and GNF BioGPS,
probe sets-to-genes annotations according to ²GeneAnnot , ³GeneTide , Sets of similar genes according to GeneDecks, Electronic Northern calculations according to data from UniGene (Build 219 Homo sapiens), SAGE tags according to CGAP, plus additional links to SOURCE, and/or GNF BioGPS, and/or EXPOLDB, and/or UniProtKB,
Expression Assays from Applied Biosystems )
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YTHDF1 expression in normal and diseased human tissues

Applied Biosystems TaqMan ® Gene Expression Assays for YTHDF1

¹ / ² / ³

3 probe-sets matching YTHDF1 gene

Affymetrix probe-set	Array	# genes	Sensitivity	Specificity	Correlation	Length	Gb_Accession	Consensus	Uniqueness	Score	Rank
Affymetrix probe-set	Array	GeneAnnot data			GeneNote data		GeneTide data
56516_at²^{, 3}	U95-B	1	1.00	1.00	1.00	1.00	AW001012	0.80	1.00	0.91	1
221741_s_at²	U133-A	1	1.00	1.00	--	--	--	--	--	--	--
221741_s_at²	U133Plus2	1	1.00	1.00	--	--	--	--	--	--	--

About this table

Data from

(Publications) and GNF BioGPS
About these images
About these images

CGAP SAGE TAG: CCTGACGCTC

SOURCE GeneReport for Unigene cluster: Hs.11747

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD and/or ⁵MGI Jun 06 2009, with possible further links to Flybase and/or WormBase, Gene Trees according to Ensembl)
About This Section

Orthologs for YTHDF1 gene from 5/13 species (see all 13 )

Organism	Gene	Locus	Description	Human Similarity	NCBI accessions
dog (Canis familiaris)	YTHDF1¹	--	YTH domain family, member 1	88.6(n) 92.98(a)	485968 XM_543093.2 XP_543093.2
chimpanzee (Pan troglodytes)	YTHDF1¹	--	YTH domain family, member 1	99.64(n) 99.64(a)	470035 XM_525419.2 XP_525419.2
cow (Bos taurus)	YTHDF1¹	--	YTH domain family, member 1	84.48(n) 88.73(a)	538525 XM_580915.3 XP_580915.3
rat (Rattus norvegicus)	Ythdf1¹	--	YTH domain family, member 1	88.07(n) 93.74(a)	296467 NM_001024756.1 NP_001019927.1
mouse (Mus musculus)	Ythdf1^{1, 5}	2⁵	YTH domain family 1^{1, 5}	88.07(n)¹ 93.92(a)¹	228994¹ NM_173761.3¹ NP_776122.1¹ AA426988⁵ AK033241⁵ (see all 16)

About this table Species with no ortholog for YTHDF1

ENSEMBL Gene Tree for YTHDF1

(Paralogs according to ¹HomoloGene
and ²Ensembl, Pseudogenes according to ³Pseudogene.org)
About This Section

Paralogs for YTHDF1 gene

YTHDF2² YTHDF3²

(According to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, and UniProtKB, Linkage Disequilibrium by HapMap, Genotyping Reagents from Applied Biosystems)
About This Section

10/139 NCBI SNPs in YTHDF1 are shown (see all 139 )
(Click for Applied Biosystems TaqMan ® Genotyping Assay) (see all 60)

AB	SNP ID	Valid	Chr 20 pos	Sequence	Recs	AA Chg	Type	More	Recs	Pop	Total sample	More
AB	Genomic Data				Transcription Data				Allele Frequencies
				--	--	--		--	--			--
--	rs6011669^1,2	A,C,F,H	61319908(+)	`AGTGCC/GGGCAA`	1	--	ng3¹		4	EU EA WA	412
	rs6090289^1,2	A,C,F,H	61296969(+)	`AGTCCA/GGAAAG`	1	--	ng5¹		11	EU EA WA NA	960
	rs6011668^1,2	A,C,F,H	61319068(+)	`TGGGGC/TAGCAG`	1	--	ng3¹		4	EU EA WA	416
	rs6090288^1,2	F,H	61296812(+)	`TCACAT/CACTTG`	1	--	ng5¹		4	EU EA WA	420
	rs6011659^1,2	F,H	61297723(+)	`AAGACG/AGCATT`	1	--	ut3¹		4	EU EA WA	420
	rs6010871^1,2	H	61298064(+)	`TTAACC/TTTTTG`	1	--	ut3¹ ese³		4	EU EA WA	396
	rs6010869^1,2	H	61297802(+)	`CAGACC/TTAAAG`	1	--	ut3¹		4	EU EA WA	420
	rs6090290^1,2	H	61297069(+)	`CTTAAG/AGAAAT`	1	--	ng5¹		4	EU EA WA	420
	rs6122392^1,2	H	61297912(+)	`TGGAAG/AGAAAG`	1	--	ut3¹ trp³		4	EU EA WA	418
	rs6122103^1,2	A,C,F,H	61305140(+)	`TTGACG/AGCGGA`	1	A/A	syn¹		7	EU EA WA NA	550

About this table

HapMap Linkage Disequilibrium images for YTHDF1 (up to first 250kb)

(in which this Gene is Involved, According to OMIM, UniProtKB, PharmGKB, Genatlas, GeneTests, Blood group antigen gene mutations by BGMUT, HGMD, GAD, HuGE Navigator, BCGD, and/or TGDB.)
About This Section

(Possibly Related Articles in Doctor's Guide)
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(in PubMed. Associations of this gene to articles via ¹Novoseek, ²HGNC, ³Entrez Gene, ⁴UniProtKB/Swiss-Prot, ⁵UniProtKB/TrEMBL, ⁶GAD, and/or ⁷PharmGKB)
About This Section

5 PubMed articles for YTHDF1 gene:

The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)^{3, 4} Gerhard D.S....Malek J. (2004)
Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)^{3, 4} Ota T....Sugano S. (2004)
The DNA sequence and comparative analysis of human chromosome 20. (PubMed id 11780052)^{3, 4} Deloukas P....Rogers J. (2001)
The full-ORF clone resource of the German cDNA Consortium. (PubMed id 17974005)⁴ Bechtel S....Schupp I. (2007)
Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)³ Strausberg R.L....Marra M.A. (2002)

(in PubMed, OMIM, and NCBI Bookshelf)
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		AND	OR
Aliases
Free Text

Query String		PubMed OMIM NCBI Bookshelf
	(Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, and/or H-InvDB)
About This Section

Entrez Gene: 54915	HGNC: 15867	AceView: YTHDF1	Ensembl:ENSG00000149658	euGenes: HUgn54915
ECgene: YTHDF1	H-InvDB: YTHDF1

(According to HUGE)
About This Section

(According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section

Licensable Technologies for YTHDF1
(Available from WIS Yeda, Salk, Tufts)

About This Section

(Reagents available from Applied Biosystems, Antibodies and assays by Cell Signaling Technology, Abcam, Novus Biologicals,
Sigma-Aldrich, R&D Systems, Millipore, Abnova, and/or Invitrogen, Clones available from OriGene,and/or Invitrogen, Drugs and/or compounds by Sigma-Aldrich,
Enzo Life Sciences, and/or Tocris Bioscience)
About This Section

Products for YTHDF1:

TaqMan ® Gene Expression Assays

TaqMan ® Genotyping Assays

Free SNP selection tool

Invitrogen iPath Pathways	Invitrogen BLOCK-iT™ RNAi
Invitrogen Antibodies	Invitrogen Assays
Invitrogen Clones	Invitrogen Q-PCR Products
Invitrogen Human Recombinant Kinases	Invitrogen Custom Antibody and Peptide Service
Invitrogen Proteins / Assays / Screening Services	Search Invitrogen catalog for YTHDF1-related products

	Millipore Custom Antibody & Bulk Services
	Millipore Preclinical / Clinical Development Services
	Millipore Immunoassay Services
	Millipore Target Screening & Profiling Services

	Predesigned and custom siRNAs for YTHDF1		Browse antibodies at Sigma-Aldrich
	Explore super-pooled esiRNAs		Browse proteins at Sigma-Aldrich
	Lentivirus-delivered shRNAs for YTHDF1		Browse small molecules at Sigma-Aldrich
	"Your Favorite Gene" Pathways		feedback

	Antibodies		Primer Pairs
	Cell Culture Products		ELISAs
	Flow Cytometry Kits		Protease Activity Assays & Reagents
	Cell Selection/Detection Kits & Reagents		ELISA/Assay Development Kits & Reagents
	Multiplex/Array Assay Kits & Reagents		ELISpot Kits & Development Modules
	Recombinant & Natural Proteins

	Recombinant Proteins (YTHDF1)
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	Custom Service for Mouse Mab
	Custom Service for Rabbit Pab from Full-length Protein

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	Tagged/untagged cDNA clones
	Validated SYBR primer pairs
	Purified proteins from HEK293T cells
	Western blot validated antibodies
	shRNA in GFP-retroviral vector

Search Tocris compounds for YTHDF1

Search www.enzolifesicences.com for proteins, assays, substrates, inhibitors & antibodies

Search Novus for antibodies for YTHDF1

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YTHDF1 Gene

protein-coding GIFtS: 46

Aliases &
Descriptions
for YTHDF1

Summaries
for YTHDF1

Genomic Location
for YTHDF1

Proteins
for YTHDF1

Protein Domains/
Families
for YTHDF1

Gene Function
for YTHDF1

Pathways & Interactions
for YTHDF1

Drugs & Compounds
for YTHDF1

Transcripts
for YTHDF1

Expression
for YTHDF1

Orthologs
for YTHDF1

Paralogs
for YTHDF1

SNPs/Variants
for YTHDF1

Disorders & Mutations
for YTHDF1

Medical News
for YTHDF1

Publications
for YTHDF1

Search for YTHDF1

Genome Databases showing YTHDF1

Other Databases showing YTHDF1

Specialized Databases showing YTHDF1

Licensable Technologies
for YTHDF1

Services
for YTHDF1

Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

YTHDF1 Gene

protein-coding GIFtS: 46

Aliases & Descriptionsfor YTHDF1

Summariesfor YTHDF1

Genomic Locationfor YTHDF1

Proteinsfor YTHDF1

Protein Domains/Familiesfor YTHDF1

Gene Functionfor YTHDF1

Pathways & Interactionsfor YTHDF1

Drugs & Compoundsfor YTHDF1

Transcriptsfor YTHDF1

Expression for YTHDF1

Orthologsfor YTHDF1

Paralogsfor YTHDF1

SNPs/Variantsfor YTHDF1

Disorders & Mutationsfor YTHDF1

Medical Newsfor YTHDF1

Publicationsfor YTHDF1

Search for YTHDF1

Genome Databases showing YTHDF1

Other Databases showing YTHDF1

Specialized Databases showing YTHDF1

Licensable Technologiesfor YTHDF1

Servicesfor YTHDF1

Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

Aliases &
Descriptions
for YTHDF1

Summaries
for YTHDF1

Genomic Location
for YTHDF1

Proteins
for YTHDF1

Protein Domains/
Families
for YTHDF1

Gene Function
for YTHDF1

Pathways & Interactions
for YTHDF1

Drugs & Compounds
for YTHDF1

Transcripts
for YTHDF1

Expression
for YTHDF1

Orthologs
for YTHDF1

Paralogs
for YTHDF1

SNPs/Variants
for YTHDF1

Disorders & Mutations
for YTHDF1

Medical News
for YTHDF1

Publications
for YTHDF1

Licensable Technologies
for YTHDF1

Services
for YTHDF1