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Aliases for YTHDF1 Gene

Aliases for YTHDF1 Gene

  • YTH N(6)-Methyladenosine RNA Binding Protein 1 2 3
  • Dermatomyositis Associated With Cancer Putative Autoantigen 1 3 4
  • YTH Domain Family, Member 1 2 3
  • YTH Domain Family 1 2 3
  • C20orf21 3 4
  • DACA-1 3 4
  • YTH Domain-Containing Family Protein 1 3
  • YTH Domain Family Protein 1 3

External Ids for YTHDF1 Gene

Previous Symbols for YTHDF1 Gene

  • C20orf21

Summaries for YTHDF1 Gene

GeneCards Summary for YTHDF1 Gene

YTHDF1 (YTH N(6)-Methyladenosine RNA Binding Protein 1) is a Protein Coding gene. Diseases associated with YTHDF1 include dermatomyositis. An important paralog of this gene is YTHDF3.

UniProtKB/Swiss-Prot for YTHDF1 Gene

  • Specifically recognizes and binds N6-methyladenosine (m6A)-containing RNAs. M6A is a modification present at internal sites of mRNAs and some non-coding RNAs and plays a role in the efficiency of mRNA splicing, processing and stability.

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for YTHDF1 Gene

Genomics for YTHDF1 Gene

Genomic Location for YTHDF1 Gene

Start:
63,195,429 bp from pter
End:
63,216,234 bp from pter
Size:
20,806 bases
Orientation:
Minus strand

Genomic View for YTHDF1 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for YTHDF1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for YTHDF1 Gene

Regulatory Elements for YTHDF1 Gene

Proteins for YTHDF1 Gene

  • Protein details for YTHDF1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9BYJ9-YTHD1_HUMAN
    Recommended name:
    YTH domain-containing family protein 1
    Protein Accession:
    Q9BYJ9
    Secondary Accessions:
    • Q8N3G5
    • Q8TBT1
    • Q96AN4
    • Q96S57
    • Q9BTI7
    • Q9NX79

    Protein attributes for YTHDF1 Gene

    Size:
    559 amino acids
    Molecular mass:
    60874 Da
    Quaternary structure:
    No Data Available

    Three dimensional structures from OCA and Proteopedia for YTHDF1 Gene

    Alternative splice isoforms for YTHDF1 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for YTHDF1 Gene

Proteomics data for YTHDF1 Gene at MOPED

Post-translational modifications for YTHDF1 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for YTHDF1 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for YTHDF1 Gene

Domains for YTHDF1 Gene

Protein Domains for YTHDF1 Gene

InterPro:
Blocks:
ProtoNet:

UniProtKB/Swiss-Prot:

YTHD1_HUMAN
Domain:
  • Contains 1 YTH domain.:
    • Q9BYJ9
genes like me logo Genes that share domains with YTHDF1: view

No data available for Gene Families for YTHDF1 Gene

Function for YTHDF1 Gene

Molecular function for YTHDF1 Gene

UniProtKB/Swiss-Prot Function: Specifically recognizes and binds N6-methyladenosine (m6A)-containing RNAs. M6A is a modification present at internal sites of mRNAs and some non-coding RNAs and plays a role in the efficiency of mRNA splicing, processing and stability.

Gene Ontology (GO) - Molecular Function for YTHDF1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0044822 poly(A) RNA binding IDA 22658674
GO:1990247 N6-methyladenosine-containing RNA binding IDA 24284625
genes like me logo Genes that share ontologies with YTHDF1: view

Phenotypes for YTHDF1 Gene

GenomeRNAi human phenotypes for YTHDF1:
genes like me logo Genes that share phenotypes with YTHDF1: view

miRNA for YTHDF1 Gene

miRTarBase miRNAs that target YTHDF1

No data available for Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targeting and HOMER Transcription for YTHDF1 Gene

Localization for YTHDF1 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for YTHDF1 Gene COMPARTMENTS Subcellular localization image for YTHDF1 gene
Compartment Confidence
cytosol 2
nucleus 2

No data available for Gene Ontology (GO) - Cellular Components for YTHDF1 Gene

Pathways for YTHDF1 Gene

SuperPathways for YTHDF1 Gene

No Data Available

Gene Ontology (GO) - Biological Process for YTHDF1 Gene

None

No data available for Pathways by source for YTHDF1 Gene

Transcripts for YTHDF1 Gene

mRNA/cDNA for YTHDF1 Gene

Unigene Clusters for YTHDF1 Gene

YTH domain family, member 1:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for YTHDF1 Gene

No ASD Table

Relevant External Links for YTHDF1 Gene

GeneLoc Exon Structure for
YTHDF1
ECgene alternative splicing isoforms for
YTHDF1

Expression for YTHDF1 Gene

mRNA expression in normal human tissues for YTHDF1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for YTHDF1 Gene

SOURCE GeneReport for Unigene cluster for YTHDF1 Gene Hs.744852

genes like me logo Genes that share expressions with YTHDF1: view

Orthologs for YTHDF1 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for YTHDF1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia YTHDF1 36
  • 98.51 (n)
  • 98.39 (a)
YTHDF1 37
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia YTHDF1 36
  • 84.62 (n)
  • 88.73 (a)
YTHDF1 37
  • 88 (a)
OneToOne
dog
(Canis familiaris)
Mammalia YTHDF1 36
  • 88.25 (n)
  • 92.72 (a)
YTHDF1 37
  • 93 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Ythdf1 36
  • 88.07 (n)
  • 93.92 (a)
Ythdf1 16
Ythdf1 37
  • 94 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia YTHDF1 37
  • 89 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia YTHDF1 37
  • 89 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Ythdf1 36
  • 88.07 (n)
  • 93.74 (a)
chicken
(Gallus gallus)
Aves YTHDF1 36
  • 80.38 (n)
  • 89.45 (a)
YTHDF1 37
  • 89 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia YTHDF1 37
  • 86 (a)
OneToOne
African clawed frog
(Xenopus laevis)
Amphibia MGC68505 36
tropical clawed frog
(Silurana tropicalis)
Amphibia MGC75606 36
ythdf1 36
  • 78.25 (n)
  • 84.66 (a)
zebrafish
(Danio rerio)
Actinopterygii ythdf1 36
  • 72.74 (n)
  • 78.45 (a)
ythdf1 37
  • 70 (a)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta CG6422 37
  • 27 (a)
OneToMany
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes -- 37
  • 28 (a)
OneToMany
corn
(Zea mays)
Liliopsida Zm.13185 36
rice
(Oryza sativa)
Liliopsida Os.7188 36
wheat
(Triticum aestivum)
Liliopsida Ta.7012 36
sea squirt
(Ciona savignyi)
Ascidiacea CSA.6332 37
  • 42 (a)
OneToMany
Species with no ortholog for YTHDF1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • worm (Caenorhabditis elegans)

Evolution for YTHDF1 Gene

ENSEMBL:
Gene Tree for YTHDF1 (if available)
TreeFam:
Gene Tree for YTHDF1 (if available)

Paralogs for YTHDF1 Gene

Paralogs for YTHDF1 Gene

Selected SIMAP similar genes for YTHDF1 Gene using alignment to 4 proteins:

Pseudogenes.org Pseudogenes for YTHDF1 Gene

genes like me logo Genes that share paralogs with YTHDF1: view

Variants for YTHDF1 Gene

Sequence variations from dbSNP and Humsavar for YTHDF1 Gene

SNP ID Clin Chr 20 pos Sequence Context AA Info Type MAF
rs1044505 -- 63,196,383(-) TATTC(G/T)GTGAG utr-variant-3-prime
rs3787510 -- 63,199,415(-) CAGCC(C/T)CCCGG intron-variant
rs3787511 -- 63,198,781(-) CACTT(C/T)GACCT intron-variant
rs4809503 -- 63,209,526(+) gccct(C/T)tggga intron-variant
rs4809504 -- 63,211,495(+) ATATG(C/T)CCACT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for YTHDF1 Gene

Variant ID Type Subtype PubMed ID
nsv913073 CNV Loss 21882294
nsv9825 CNV Gain 18304495
dgv4618n71 CNV Loss 21882294
nsv913161 CNV Loss 21882294
dgv68n68 CNV Loss 17160897
nsv913165 CNV Loss 21882294
nsv913166 CNV Loss 21882294
nsv834031 CNV Loss 17160897
dgv519n27 CNV Loss 19166990
dgv4626n71 CNV Loss 21882294
dgv4627n71 CNV Loss 21882294
nsv828798 CNV Loss 20364138
esv2722892 CNV Deletion 23290073
nsv527884 CNV Loss 19592680
dgv4628n71 CNV Loss 21882294
dgv4629n71 CNV Loss 21882294
nsv834032 CNV Loss 17160897

Relevant External Links for YTHDF1 Gene

HapMap Linkage Disequilibrium report
YTHDF1

Disorders for YTHDF1 Gene

(1) MalaCards Diseases for YTHDF1 Gene

Search for YTHDF1 Gene in MalaCards »
genes like me logo Genes that share disorders with YTHDF1: view

No data available for UniProtKB/Swiss-Prot for YTHDF1 Gene

Publications for YTHDF1 Gene

  1. N-methyladenosine-dependent regulation of messenger RNA stability. (PMID: 24284625) Wang X. … He C. (Nature 2014) 2 3 4
  2. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4
  4. The DNA sequence and comparative analysis of human chromosome 20. (PMID: 11780052) Deloukas P. … Rogers J. (Nature 2001) 3 4
  5. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg R.L. … Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002) 3

Products for YTHDF1 Gene

Sources for YTHDF1 Gene

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