YTHDF1 Gene
protein-coding GIFtS: 45
GCID: GC20M061826
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YTH domain family, member 1(Previous name: YTH domain family 1 )
(Previous symbol: C20orf21)
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Aliases
for YTHDF1 gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| YTH Domain Family, Member 11 2 | | DACA-12 3 | | C20orf211 2 3 | | FLJ203911 | | YTH Domain Family 11 2 | | YTH Domain Family Protein 12 | | Dermatomyositis Associated With Cancer Putative Autoantigen 12 3 | | |
Export aliases for YTHDF1 gene to outside databasesPrevious GC identifers: GC20M062554 GC20M061297 GC20M058551 |
Summaries
for YTHDF1 gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
-- |
Genomic Views
for YTHDF1 gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000020.10 NC_018931.1 NT_011333.6
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the YTHDF1 gene promoter:
SRF TBP N-Myc SRF (504 AA) TFIID Cart-1 C/EBPalpha HNF-4alpha1
Other transcription factors
Search SABiosciences Chromatin IP Primers for YTHDF1
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat YTHDF1 |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 20q13.33 Ensembl cytogenetic band: 20q13.33 HGNC cytogenetic band: 20q13.33YTHDF1 Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 20 GeneLoc Exon Structure GeneLoc location for GC20M061826: view genomic region
(about GC identifiers)
Start:
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61,826,781 bp from pter |
End:
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61,847,586 bp from pter |
Size:
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20,806 bases |
Orientation:
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minus strand |
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Proteins
for YTHDF1 gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: YTHD1_HUMAN, Q9BYJ9 (See
protein sequence)Recommended Name: YTH domain family protein 1 Size: 559 amino acids; 60874 Da
Secondary accessions: Q8N3G5 Q8TBT1 Q96AN4 Q96S57 Q9BTI7 Q9NX79Alternative splicing: 2 isoforms: Q9BYJ9-1 Q9BYJ9-2 (No experimental confirmation available)Explore the universe of human proteins at neXtProt for YTHDF1: NX_Q9BYJ9
Post-translational modifications:
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_Q9BYJ9
YTHDF1 Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins: NP_060268.2
ENSEMBL proteins: ENSP00000359364 ENSP00000359359 ENSP00000359358
Human Recombinant Protein Products for YTHDF1:
YTHDF1 Antibody Products:
Assay Products for YTHDF1: |
Protein
Domains /
Families
for YTHDF1 gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
YTHDF1 for domains About GeneDecksing
1 InterPro domain/family:Graphical View of Domain Structure for InterPro Entry Q9BYJ9ProtoNet protein and cluster: Q9BYJ9 1 Blocks protein family: IPB007275 YT521-B-like protein
UniProtKB/Swiss-Prot: YTHD1_HUMAN, Q9BYJ9Similarity: Contains 1 YTH domain |
Function
for YTHDF1 gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
inGenious Targeting Laboratory,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase,
shRNA from
OriGene,
Sirion Biotech,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Sirion Biotech,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
Sirion Biotech,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Phenotypes:
1 GenomeRNAi human phenotype for YTHDF1:
1 MGI phenotypic allele  for Ythdf1 (no phenotypes)
YTHDF1 for phenotypes About GeneDecksing
Animal Models:
Clone
Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for YTHDF1 (see all 3)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for YTHDF1
OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling 
| |  | GenScript: all cDNA clones in your preferred vector: YTHDF1 (NM_017798) | |  | Browse Sino Biological Human cDNA Clones | |  | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for YTHDF1 | |  | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat YTHDF1 |
In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for YTHDF1 |
|
Pathways & Interactions
for YTHDF1 gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Interactions:
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for YTHDF1
STRING Interaction
Network Preview (showing 5 interactants - click image to see 7)
5/11 Interacting proteins for YTHDF1 (Q9BYJ92, 3 ENSP000003593644) via UniProtKB, MINT, STRING, and/or I2D (see all 11)About this table
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Drugs & Compounds
for YTHDF1 gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
 Browse Tocris compounds for YTHDF1
Search CenterWatch for drugs/clinical trials and news about YTHDF1 / YTHD1
|
Transcripts
for YTHDF1 gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
Sirion Biotech,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for YTHDF1 gene: NM_017798.3 Unigene Cluster for YTHDF1: YTH domain family, member 1 Hs.11747 [show with all ESTs]Unigene Representative Sequence: NM_0177983 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000370339(uc011aaq.2 uc002yeh.3) ENST00000370334 ENST00000370333
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for YTHDF1 (see all 3)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for YTHDF1
OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector: YTHDF1 (NM_017798) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for YTHDF1 | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat YTHDF1 |
Additional cDNA sequence: AB055518.1 AK000398.1 AK024546.1 AK095795.1 AK300073.1 AL834366.1 BC003681.1 BC016920.2 BC025264.1 BC050284.1 9 DOTS entries: DT.91802563 DT.120833622 DT.95289733 DT.102831513 DT.95289731 DT.95289732 DT.95289734 DT.99994499 DT.100027658 24/237 AceView cDNA sequences (see all 237): AI146287 AA099708 W52047 AI479039 AI359773 AI299526 BM126951 AV729585 AI421444 AI198090 AA301454 BM021311 BM748094 AI078340 AW769250 AL550164 AI553931 BQ186004 AW117956 AI418135 NM_017798 BU859969 BM194314 CD673219
GeneLoc Exon Structure
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Expression
for YTHDF1 gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| YTHDF1 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: CCTGACGCTC
About this image
See YTHDF1 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for YTHDF1
SOURCE GeneReport for Unigene cluster: Hs.11747
SABiosciences Custom PCR Arrays for YTHDF1
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for YTHDF1
Browse OriGene validated miRNA SYBR primer pairs
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse, rat YTHDF1 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat YTHDF1 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat YTHDF1 | In Situ
Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for YTHDF1 |
Orthologs
for YTHDF1 gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of eukaryotes.
Orthologs for YTHDF1 gene from 8/26 species (see all 26) About this table
ENSEMBL Gene Tree for YTHDF1 (if available)
TreeFam Gene Tree for YTHDF1 (if available) |
Paralogs
for YTHDF1 gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| Paralogs for YTHDF1 gene
- YTHDF22
4 SIMAP similar genes for YTHDF1 using alignment to 4 protein entries: YTHD1_HUMAN (see all proteins):YTHDF3 DKFZp451A052 YTHDF2 DKFZp451J085
YTHDF1 for paralogs About GeneDecksing
2 Pseudogenes.org Pseudogenes for YTHDF1
PGOHUM00000258202 PGOHUM00000243552
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Genomic Variants
for YTHDF1 gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 20 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for YTHDF1 (61826781 - 61847586 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 5 variations for YTHDF1
5 CNVs: 5148 5146 5147 31044 53464 | SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing YTHDF1 |
|
Disorders
/ Diseases
for YTHDF1 gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
YTHDF1 for disorders About GeneDecksing
3  diseases for YTHDF1: About MalaCardsdermatomyositis pancreatic cancer pancreatitis
Export disorders for YTHDF1 gene to outside databases
|
Publications
for YTHDF1 gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for YTHDF1 gene, integrated from 9 sources (see all 19):
(articles sorted by number of sources associating them with YTHDF1) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
- Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
- The DNA sequence and comparative analysis of human chromosome 20. (PubMed id 11780052)1, 2 Deloukas P....Rogers J. (2001)
- A census of human soluble protein complexes. (PubMed id 22939629)1 Havugimana P.C....Emili A. (2012)
- Mapping a dynamic innate immunity protein interaction network regulating type I interferon production. (PubMed id 21903422)1 Li S....Dorf M.E. (2011)
- Initial characterization of the human central proteome. (PubMed id 21269460)2 Burkard T.R.... Colinge J. (2011)
- Systematic and quantitative assessment of the ubiquiti n-modified proteome. (PubMed id 21906983)1 Kim W....Gygi S.P. (2011)
- System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation. (PubMed id 21406692)2 Rigbolt K.T....Blagoev B. (2011)
- Mass spectrometric analysis of lysine ubiquitylation r eveals promiscuity at site level. (PubMed id 21139048)1 Danielsen J.M....Nielsen M.L. (2011)
- Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis. (PubMed id 20068231)2 Olsen J.V....Mann M. (2010)
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External Searches for YTHDF1 gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
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Genome Databases showing YTHDF1 gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing YTHDF1 gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing YTHDF1 gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
| Name | Description |
| PharmGKB entry for YTHDF1 | Pharmacogenomics, SNPs, Pathways |
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| | |
About This Section
| Patent Information for YTHDF1 gene:
Search GeneIP for patents involving YTHDF1
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for YTHDF1 gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript, LifeMap BioReagents, and Sirion Biotech, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences, In Situ Hybridization Assays from
Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory)
About This Section
|
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 | |
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| | |  | Browse OriGene Antibodies | | OriGene shRNA RFP for YTHDF1 | | | OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for YTHDF1 | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for YTHDF1 | | | OriGene Protein Over-expression Lysate for YTHDF1 | | Browse OriGene Fluorogenic Cell Assay Kits | | | Browse OriGene siRNAs | | OriGene 3'-UTR Clone for YTHDF1 | | | OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for YTHDF1 | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for YTHDF1 | | | Browse OriGene GFP tagged cDNA clones in CMV expression vector | | Browse OriGene MicroRNA Expression Plasmids | | | Browse OriGene basic RS shRNAs | | Browse OriGene validated miRNA SYBR primer pairs | | | OriGene Purified Protein for YTHDF1 | | OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling | | | OriGene Custom Antibody Services for YTHDF1 | | OriGene Custom Protein Services for YTHDF1 | | | OriGene Custom Immunoassay Development | | |
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| | | QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat YTHDF1 | | | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing YTHDF1 | | | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat YTHDF1 | | | QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat YTHDF1 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat YTHDF1 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat YTHDF1 |
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| | | | Search Tocris compounds for YTHDF1 |
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 | | | YTHDF1 Proteins, Antibodies, CLIAs, and ELISAs |
| | | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for YTHDF1 |
|  |  |  |  | | | | Search ThermoFisher Antibodies for YTHDF1 |
| | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat YTHDF1 |
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