Aliases for YTHDF1 Gene
External Ids for YTHDF1 Gene
Previous HGNC Symbols for YTHDF1 Gene
Previous GeneCards Identifiers for YTHDF1 Gene
GeneCards Summary for YTHDF1 Gene
YTHDF1 (YTH N6-Methyladenosine RNA Binding Protein 1) is a Protein Coding gene. GO annotations related to this gene include poly(A) RNA binding and N6-methyladenosine-containing RNA binding. An important paralog of this gene is YTHDF3.
UniProtKB/Swiss-Prot for YTHDF1 Gene
Specifically recognizes and binds N6-methyladenosine (m6A)-containing mRNAs, and promotes mRNA translation efficiency (PubMed:24284625, PubMed:26046440, PubMed:26318451). M6A is a modification present at internal sites of mRNAs and some non-coding RNAs and plays a role in the efficiency of mRNA splicing, processing and stability (PubMed:24284625). Acts as a regulator of mRNA translation efficiency: promotes ribosome loading to m6A-containing mRNAs and interacts with translation initiation factors eIF3 (EIF3A or EIF3B) to facilitate translation initiation (PubMed:26046440).