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YTHDC2 Gene

protein-coding   GIFtS: 50
GCID: GC05P112877

YTH Domain Containing 2

Pneumococci & Pneumococcal Diseases Congress
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
YTH Domain Containing 21 2
CAHL2
CsA-Associated Helicase-Like Protein2
Probable ATP-Dependent RNA Helicase YTHDC22
EC 3.6.4.133
EC 3.6.18

External Ids:    HGNC: 247211   Entrez Gene: 648482   Ensembl: ENSG000000471887   UniProtKB: Q9H6S03   

Export aliases for YTHDC2 gene to outside databases

Previous GC identifers: GC05P112926 GC05P108032


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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GeneCards Summary for YTHDC2 Gene:
YTHDC2 (YTH domain containing 2) is a protein-coding gene. Diseases associated with YTHDC2 include coronary artery disease, and hepatitis c virus. GO annotations related to this gene include ATP-dependent helicase activity and nucleic acid binding. An important paralog of this gene is DHX29.


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence:
NC_000005.10  NT_034772.7  NC_018916.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the YTHDC2 gene promoter:
         ISGF-3   POU3F1   NCX/Ncx   C/EBPalpha   GATA-1   CREB   PPAR-gamma1   deltaCREB   PPAR-gamma2   ATF   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidYTHDC2 promoter sequence
   Search Chromatin IP Primers for YTHDC2

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat YTHDC2


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 5q22.2   Ensembl cytogenetic band:  5q22.2   HGNC cytogenetic band: 5q22.3

YTHDC2 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
YTHDC2 gene location

GeneLoc information about chromosome 5         GeneLoc Exon Structure

GeneLoc location for GC05P112877:  view genomic region     (about GC identifiers)

Start:
112,849,380 bp from pter      End:
112,930,984 bp from pter
Size:
81,605 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
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UniProtKB/Swiss-Prot: YTDC2_HUMAN, Q9H6S0 (See protein sequence)
Recommended Name: Probable ATP-dependent RNA helicase YTHDC2  
Size: 1430 amino acids; 160248 Da
Sequence caution: Sequence=BAB15183.1; Type=Erroneous initiation;
1 PDB 3D structure from and Proteopedia for YTHDC2:
2YU6 (3D)    
Secondary accessions: B2RP66

Explore the universe of human proteins at neXtProt for YTHDC2: NX_Q9H6S0

Explore proteomics data for YTHDC2 at MOPED

Post-translational modifications: 

  • Ubiquitination2 at Lys1307
  • Modification sites at PhosphoSitePlus
  • Selected DME Specific Peptides for YTHDC2 (Q9H6S0) (see all 6)
     TNIAETS  VDEVHER  GKTTQIPQ  ILSTNIAE 


    See YTHDC2 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_073739.3  
    ENSEMBL proteins: 
     ENSP00000161863   ENSP00000426644   ENSP00000423101   ENSP00000422916  

    YTHDC2 Human Recombinant Protein Products:

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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    Selected InterPro protein domains (see all 10):
     IPR011545 DNA/RNA_helicase_DEAD/DEAH_N
     IPR001374 R3H_ss-bd
     IPR002110 Ankyrin_rpt
     IPR007502 Helicase-assoc_dom
     IPR011709 DUF1605

    Graphical View of Domain Structure for InterPro Entry Q9H6S0

    ProtoNet protein and cluster: Q9H6S0

    UniProtKB/Swiss-Prot: YTDC2_HUMAN, Q9H6S0
    Domain: The YTH domain mediates RNA-binding (By similarity)
    Similarity: Belongs to the DEAD box helicase family. DEAH subfamily
    Similarity: Contains 2 ANK repeats
    Similarity: Contains 1 helicase ATP-binding domain
    Similarity: Contains 1 helicase C-terminal domain
    Similarity: Contains 1 R3H domain
    Similarity: Contains 1 YTH domain


    YTHDC2 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: YTDC2_HUMAN, Q9H6S0
    Catalytic activity: ATP + H(2)O = ADP + phosphate

         Enzyme Numbers (IUBMB): EC 3.6.12 EC 3.6.4.131

         Gene Ontology (GO): Selected molecular function terms (see all 6):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003676nucleic acid binding ----
    GO:0004386helicase activity ----
    GO:0005515protein binding IPI--
    GO:0005524ATP binding IEA--
    GO:0008026ATP-dependent helicase activity IEA--
         
    YTHDC2 for ontologies           About GeneDecksing


    Phenotypes:
         1 GenomeRNAi human phenotype for YTHDC2:
     Decreased p24 protein expressi 

    Animal Models:
       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for YTHDC2
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       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for YTHDC2

    miRNA
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    miRTarBase miRNAs that target YTHDC2:
    hsa-mir-96-5p (MIRT048734), hsa-mir-30c-5p (MIRT047966), hsa-mir-505-3p (MIRT041048)

    Block miRNA regulation of human, mouse, rat YTHDC2 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate YTHDC2 (see all 20):
    hsa-miR-495 hsa-miR-607 hsa-miR-181c hsa-miR-520d-5p hsa-miR-4328 hsa-miR-148b hsa-miR-513c hsa-miR-129-3p
    SwitchGear 3'UTR luciferase reporter plasmidYTHDC2 3' UTR sequence
    Inhib. RNA
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    Predesigned siRNA for gene silencing in human, mouse, rat YTHDC2

    Gene Editing
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    OriGene ORF clones in mouse, rat for YTHDC2
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    GenScript: all cDNA clones in your preferred vector: YTHDC2 (NM_022828)
    Browse Sino Biological Human cDNA Clones
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    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat YTHDC2

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    In Situ Assay
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for YTHDC2


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    nucleus3
    cytoskeleton1
    cytosol1
    mitochondrion1
    peroxisome1
    plasma membrane1

    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for YTHDC2
    Interactions:

        Search GeneGlobe Interaction Network for YTHDC2

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for YTHDC2 (Q9H6S01, 2, 3 ENSP000001618634) via UniProtKB, MINT, STRING, and/or I2D (see all 694)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    SQSTM1Q135012, 3MINT-7945693 I2D: score=1 
    IRF4Q153061, 3, ENSP000003703434EBI-1057466,EBI-751345 I2D: score=1 STRING: ENSP00000370343
    USP42Q9H9J43, ENSP000003019624I2D: score=2 STRING: ENSP00000301962
    IRAK1P516173, ENSP000003589974I2D: score=1 STRING: ENSP00000358997
    EXOSC10Q017802, ENSP000003661354MINT-7945693 STRING: ENSP00000366135
    About this table

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for YTHDC2 (YTDC2)



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
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    REFSEQ mRNAs for YTHDC2 gene: 
    NM_022828.3  

    Unigene Cluster for YTHDC2:

    YTH domain containing 2
    Hs.231942  [show with all ESTs]
    Unigene Representative Sequence: NM_022828
    7 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000161863(uc003kqn.3) ENST00000503857(uc010jcf.2) ENST00000515883(uc010jce.2)
    ENST00000514720 ENST00000506333 ENST00000512600 ENST00000507567

    miRNA
    Products:
         
    Block miRNA regulation of human, mouse, rat YTHDC2 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate YTHDC2 (see all 20):
    hsa-miR-495 hsa-miR-607 hsa-miR-181c hsa-miR-520d-5p hsa-miR-4328 hsa-miR-148b hsa-miR-513c hsa-miR-129-3p
    SwitchGear 3'UTR luciferase reporter plasmidYTHDC2 3' UTR sequence
    Inhib. RNA
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    OriGene RNAi products in human, mouse, rat for YTHDC2
    Predesigned siRNA for gene silencing in human, mouse, rat YTHDC2
    Clone
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    OriGene clones in human, mouse for YTHDC2 (see all 7)
    OriGene ORF clones in mouse, rat for YTHDC2
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: YTHDC2 (NM_022828)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for YTHDC2
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat YTHDC2
    Primer
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    OriGene qSTAR qPCR primer pairs in human, mouse for YTHDC2
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat YTHDC2
      QuantiTect SYBR Green Assays in human, mouse, rat YTHDC2
      QuantiFast Probe-based Assays in human, mouse, rat YTHDC2

    Additional mRNA sequence: 

    AK025593.1 AK096486.1 AK131450.1 AK225316.1 AK310855.1 AL049305.1 BC019100.2 BC137285.1 

    11 DOTS entries:

    DT.91754242  DT.40131006  DT.113188  DT.100022403  DT.91754228  DT.95272922  DT.100012653  DT.120812363 
    DT.97793725  DT.91660640  DT.95272923 

    Selected AceView cDNA sequences (see all 168):

    BX095474 AA976993 AI434990 BG203583 BU183816 AA922641 AI207209 NM_022828 
    AA282082 CB268902 BC019100 BX437705 AA283156 AA309730 AI332392 AW514633 
    AI887563 AK095368 AA976570 CR614354 BF056966 AI992372 AI219789 AI367658 

    GeneLoc Exon Structure

    Selected Alternative Splicing Database (ASD) splice patterns (SP) for YTHDC2 (see all 8)    About this scheme

    ExUns: 1a · 1b ^ 2 ^ 3 ^ 4 ^ 5a · 5b ^ 6a · 6b ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12 ^ 13a · 13b · 13c ^ 14 ^ 15 ^ 16 ^ 17a · 17b ^ 18a · 18b ^ 19 ^
    SP1:                                                                                                                                                            
    SP2:              -                                                                                                                                             
    SP3:                                                                                                                                                            
    SP4:                                                                                                                          -     -                           
    SP5:                                                                                                                                                            

    ExUns: 20a · 20b ^ 21a · 21b · 21c ^ 22a · 22b ^ 23
    SP1:              -                       -         
    SP2:                                                
    SP3:  -           -                                 
    SP4:                                                
    SP5:                                                


    ECgene alternative splicing isoforms for YTHDC2

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    YTHDC2 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: TACTTAATAG
    YTHDC2 Expression
    About this image

    YTHDC2 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    YTHDC2 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.231942
        Custom PCR Arrays for YTHDC2
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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for YTHDC2

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of eukaryotes.

    Orthologs for YTHDC2 gene from Selected species (see all 17)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Ythdc21 , 5 YTH domain containing 21, 5 91.33(n)1
    96.64(a)1
      18 (23.81 cM)5
    2402551  NM_001163013.11  NP_001156485.11 
     448286655 
    chicken
    (Gallus gallus)
    Aves YTHDC21 YTH domain containing 2 77.93(n)
    80.27(a)
      415602  XM_413970.4  XP_413970.2 
    lizard
    (Anolis carolinensis)
    Reptilia YTHDC26
    YTH domain containing 2
    90(a)
    1 ↔ 1
    GL343193.1(7347220-7380577)
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia ythdc21 YTH domain containing 2 73.84(n)
    81.39(a)
      779469  XM_002936413.2  XP_002936459.2 
    zebrafish
    (Danio rerio)
    Actinopterygii LOC5671141 probable ATP-dependent RNA helicase YTHDC2-like 62.4(n)
    69.15(a)
      567114  XM_690404.6  XP_695496.6 
    fruit fly
    (Drosophila melanogaster)
    Insecta bgcn6
    benign gonial cell neoplasm
    23(a)
    1 ↔ 1
    2R(19740801-19746314)
    worm
    (Caenorhabditis elegans)
    Secernentea F52B5.36
    Protein F52B5.3 (F52B5.3) mRNA, complete cds
    23(a)
    1 ↔ 1
    I(8318346-8323983) WBGene00009922
    thale cress
    (Arabidopsis thaliana)
    eudicotyledons HVT11 HVT1 48.66(n)
    37.22(a)
      817631  NM_179823.3  NP_850154.2 
    rice
    (Oryza sativa)
    Liliopsida Os.455072 Oryza sativa (japonica cultivar-group) putative ATP-dependent more 74(n)    NM_184116.1 


    ENSEMBL Gene Tree for YTHDC2 (if available)
    TreeFam Gene Tree for YTHDC2 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for YTHDC2 gene
    DHX292  DHX302  DHX362  TDRD92  DHX572  DHX92  
    2 SIMAP similar genes for YTHDC2 using alignment to 4 protein entries:     YTDC2_HUMAN (see all proteins):
    PPP1R12A    DHX36

    YTHDC2 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for YTHDC2 (see all 2075)    About this table    
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 5 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1424750901,2
    C,Funtested1112868683(+) GTTGCC/TGCAGA 2 A syn12Minor allele frequency- T:0.00NA EU 5871
    rs785184161,2
    C--112847398(+) GTTCCA/GGAGAA 1 -- us2k10--------
    rs1381880261,2
    C--112847519(+) GGGTG-/GGAGGAGG 1 -- cds10--------
    rs1908920091,2
    --112847595(+) GTCAAC/TTTTAT 1 -- us2k10--------
    rs757975321,2
    F--112847647(+) TGCTCG/ATATGC 1 -- us2k11Minor allele frequency- A:0.03WA 118
    rs785982281,2
    --112847650(+) TCGTAC/TGCCAC 1 -- us2k10--------
    rs1471091391,2
    --112847653(+) TATGCC/TACAAG 1 -- us2k10--------
    rs18200581,2
    C,F--112847671(-) TGATAT/AGCCTG 1 -- us2k11Minor allele frequency- A:0.03NA 120
    rs1379449671,2
    --112847694(+) CCCCAG/TTTCTT 1 -- us2k10--------
    rs68715671,2
    C,F--112847801(+) CAGAAC/TAAGCT 1 -- us2k1 tfbs30--------

    HapMap Linkage Disequilibrium report for YTHDC2 (112849380 - 112930984 bp)

    Structural Variations
         Database of Genomic Variants (DGV) Selected variations for YTHDC2 (see all 15):    About this table    
    Variant IDTypeSubtypePubMed ID
    esv2730604CNV Deletion23290073
    esv2162364CNV Deletion18987734
    esv1743798CNV Deletion17803354
    esv2730606CNV Deletion23290073
    esv2730605CNV Deletion23290073
    esv2730608CNV Deletion23290073
    dgv1000e201CNV Deletion23290073
    esv2540445CNV Deletion19546169
    dgv208n6CNV Loss16902084
    nsv882724CNV Loss21882294

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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    6 diseases for YTHDC2:    
    About MalaCards
    coronary artery disease    hepatitis c virus    hepatitis c    hepatitis
    hiv-1    malaria


    YTHDC2 for disorders           About GeneDecksing


    Congresses - knowledge worth sharing:
    The International Symposium on Pneumococci and Pneumococcal Diseases (ISPPD) 9 - 13 March 2014
    Genetic Association Database (GAD): YTHDC2
    Human Genome Epidemiology (HuGE) Navigator: YTHDC2 (2 documents)

    Export disorders for YTHDC2 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for YTHDC2 gene, integrated from 10 sources (see all 33):
    (articles sorted by number of sources associating them with YTHDC2)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Genome-wide association study identifies genetic variants influencing F-cell levels in sickle-cell patients. (PubMed id 21326311)1, 4 Bhatnagar P....Keefer J.R. (J. Hum. Genet. 2011)
    2. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (Nat. Genet. 2004)
    3. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1, 3 Strausberg R.L....Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002)
    4. Transcriptional machinery of TNF-I+-inducible YTH domain containing 2 (YTHDC2) gene. (PubMed id 24269672)1 Tanabe A....Sahara H. (Gene 2014)
    5. Functional proteomics establishes the interaction of SIRT7 with chromatin remodeling complexes and expands its role in regulation of RNA polymerase I transcription. (PubMed id 22586326)1 Tsai Y.C.... Cristea I.M. (Mol. Cell. Proteomics 2012)
    6. Mapping a dynamic innate immunity protein interaction network regulating type I interferon production. (PubMed id 21903422)1 Li S.... Dorf M.E. (Immunity 2011)
    7. Initial characterization of the human central proteome. (PubMed id 21269460)2 Burkard T.R.... Colinge J. (BMC Syst. Biol. 2011)
    8. Cyclosporin A associated helicase-like protein facilitates the association of hepatitis C virus RNA polymerase with its cellular cyclophilin B. (PubMed id 21559518)1 Morohashi K....Sugawara F. (PLoS ONE 2011)
    9. A proteome-wide, quantitative survey of in vivo ubiquitylation sites reveals widespread regulatory roles. (PubMed id 21890473)1 Wagner S.A....Choudhary C. (amp 2011)
    10. Interaction proteomics analysis of polycomb proteins defines distinct PRC1 Complexes in mammalian cells. (PubMed id 21282530)1 Vandamme J.... Angrand P.O. (Mol. Cell. Proteomics 2011)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 64848 HGNC: 24721 AceView: YTHDC2 Ensembl:ENSG00000047188 euGenes: HUgn64848
    ECgene: YTHDC2 H-InvDB: YTHDC2

    (According to HUGE)
    About This Section

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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for YTHDC2 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section

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    Patent Information for YTHDC2 gene:
    Search GeneIP for patents involving YTHDC2

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript, and ESI BIO, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
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