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Aliases for YTHDC2 Gene

Aliases for YTHDC2 Gene

  • YTH Domain Containing 2 2 3
  • Probable ATP-Dependent RNA Helicase YTHDC2 3
  • CsA-Associated Helicase-Like Protein 3
  • EC 4
  • EC 3.6.1 63
  • CAHL 3

External Ids for YTHDC2 Gene

Previous GeneCards Identifiers for YTHDC2 Gene

  • GC05P112926
  • GC05P112877
  • GC05P108032

Summaries for YTHDC2 Gene

GeneCards Summary for YTHDC2 Gene

YTHDC2 (YTH Domain Containing 2) is a Protein Coding gene. GO annotations related to this gene include nucleic acid binding and ATP-dependent helicase activity. An important paralog of this gene is DHX29.

UniProtKB/Swiss-Prot for YTHDC2 Gene

  • Specifically recognizes and binds N6-methyladenosine (m6A)-containing RNAs. M6A is a modification present at internal sites of mRNAs and some non-coding RNAs and plays a role in the efficiency of mRNA splicing, processing and stability.

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for YTHDC2 Gene

Genomics for YTHDC2 Gene

Regulatory Elements for YTHDC2 Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for YTHDC2 Gene

113,513,683 bp from pter
113,595,287 bp from pter
81,605 bases
Plus strand

Genomic View for YTHDC2 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for YTHDC2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for YTHDC2 Gene

Proteins for YTHDC2 Gene

  • Protein details for YTHDC2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Probable ATP-dependent RNA helicase YTHDC2
    Protein Accession:
    Secondary Accessions:
    • B2RP66

    Protein attributes for YTHDC2 Gene

    1430 amino acids
    Molecular mass:
    160248 Da
    Quaternary structure:
    No Data Available
    • Sequence=BAB15183.1; Type=Erroneous initiation; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for YTHDC2 Gene

neXtProt entry for YTHDC2 Gene

Proteomics data for YTHDC2 Gene at MOPED

Selected DME Specific Peptides for YTHDC2 Gene

Post-translational modifications for YTHDC2 Gene

  • Ubiquitination at Lys1307
  • Modification sites at PhosphoSitePlus

Other Protein References for YTHDC2 Gene

Domains for YTHDC2 Gene

Suggested Antigen Peptide Sequences for YTHDC2 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Q9H6S0
  • The YTH domain mediates RNA-binding.
  • Contains 1 helicase ATP-binding domain.
  • Contains 1 helicase C-terminal domain.
  • Contains 1 R3H domain.
  • Contains 1 YTH domain.
  • Belongs to the DEAD box helicase family. DEAH subfamily.
  • Contains 2 ANK repeats.
genes like me logo Genes that share domains with YTHDC2: view

No data available for Gene Families for YTHDC2 Gene

Function for YTHDC2 Gene

Molecular function for YTHDC2 Gene

UniProtKB/Swiss-Prot CatalyticActivity: ATP + H(2)O = ADP + phosphate
UniProtKB/Swiss-Prot Function: Specifically recognizes and binds N6-methyladenosine (m6A)-containing RNAs. M6A is a modification present at internal sites of mRNAs and some non-coding RNAs and plays a role in the efficiency of mRNA splicing, processing and stability.

Enzyme Numbers (IUBMB) for YTHDC2 Gene

Gene Ontology (GO) - Molecular Function for YTHDC2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003676 nucleic acid binding --
GO:0004004 ATP-dependent RNA helicase activity IBA --
GO:0004386 helicase activity --
GO:0005515 protein binding IPI 21903422
GO:0005524 ATP binding IEA --
genes like me logo Genes that share ontologies with YTHDC2: view

Phenotypes for YTHDC2 Gene

GenomeRNAi human phenotypes for YTHDC2:
genes like me logo Genes that share phenotypes with YTHDC2: view

Animal Model Products

CRISPR Products

miRNA for YTHDC2 Gene

miRTarBase miRNAs that target YTHDC2

No data available for Animal Models , Transcription Factor Targeting and HOMER Transcription for YTHDC2 Gene

Localization for YTHDC2 Gene

Subcellular locations from

Jensen Localization Image for YTHDC2 Gene COMPARTMENTS Subcellular localization image for YTHDC2 gene
Compartment Confidence
nucleus 3
cytoskeleton 1
cytosol 1
mitochondrion 1
peroxisome 1
plasma membrane 1

Gene Ontology (GO) - Cellular Components for YTHDC2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IBA --
GO:0005783 colocalizes_with endoplasmic reticulum IDA 21559518
genes like me logo Genes that share ontologies with YTHDC2: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot for YTHDC2 Gene

Pathways for YTHDC2 Gene

SuperPathways for YTHDC2 Gene

No Data Available

Gene Ontology (GO) - Biological Process for YTHDC2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006200 obsolete ATP catabolic process --
GO:0006396 RNA processing IBA --
GO:0034612 response to tumor necrosis factor IDA 21559518
GO:0044829 positive regulation by host of viral genome replication IMP 21559518
GO:0070555 response to interleukin-1 IDA 21559518
genes like me logo Genes that share ontologies with YTHDC2: view

No data available for Pathways by source for YTHDC2 Gene

Transcripts for YTHDC2 Gene

Unigene Clusters for YTHDC2 Gene

YTH domain containing 2:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for YTHDC2

Primer Products

  • OriGene qSTAR qPCR primer pairs in human,mouse,rat for YTHDC2

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for YTHDC2 Gene

ExUns: 1a · 1b ^ 2 ^ 3 ^ 4 ^ 5a · 5b ^ 6a · 6b ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12 ^ 13a · 13b · 13c ^ 14 ^ 15 ^ 16 ^ 17a · 17b ^ 18a · 18b ^ 19 ^
SP2: -
SP4: - -
SP7: - - - -

ExUns: 20a · 20b ^ 21a · 21b · 21c ^ 22a · 22b ^ 23
SP1: - -
SP3: - -

Relevant External Links for YTHDC2 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for YTHDC2 Gene

mRNA expression in normal human tissues for YTHDC2 Gene

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for YTHDC2 Gene

SOURCE GeneReport for Unigene cluster for YTHDC2 Gene Hs.231942

genes like me logo Genes that share expressions with YTHDC2: view

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for YTHDC2 Gene

Orthologs for YTHDC2 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for YTHDC2 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia YTHDC2 35
  • 99.6 (n)
  • 99.58 (a)
  • 100 (a)
(Bos Taurus)
Mammalia YTHDC2 35
  • 93.4 (n)
  • 96.64 (a)
  • 97 (a)
(Canis familiaris)
Mammalia LOC474641 35
  • 93.78 (n)
  • 97.49 (a)
  • 95 (a)
(Mus musculus)
Mammalia Ythdc2 35
  • 91.33 (n)
  • 96.64 (a)
Ythdc2 16
Ythdc2 36
  • 96 (a)
(Monodelphis domestica)
Mammalia YTHDC2 36
  • 95 (a)
(Ornithorhynchus anatinus)
Mammalia YTHDC2 36
  • 70 (a)
(Rattus norvegicus)
Mammalia Ythdc2 35
  • 89.91 (n)
  • 94.24 (a)
(Gallus gallus)
Aves YTHDC2 35
  • 77.93 (n)
  • 80.27 (a)
  • 80 (a)
(Anolis carolinensis)
Reptilia YTHDC2 36
  • 90 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia ythdc2 35
  • 73.84 (n)
  • 81.39 (a)
(Danio rerio)
Actinopterygii LOC567114 35
  • 62.4 (n)
  • 69.15 (a)
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP007953 35
  • 49.92 (n)
  • 41.45 (a)
fruit fly
(Drosophila melanogaster)
Insecta bgcn 36
  • 23 (a)
(Caenorhabditis elegans)
Secernentea F52B5.3 36
  • 23 (a)
thale cress
(Arabidopsis thaliana)
eudicotyledons HVT1 35
  • 48.66 (n)
  • 37.22 (a)
(Oryza sativa)
Liliopsida Os.45507 35
Os01g0767700 35
  • 49.24 (n)
  • 39.05 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 38 (a)
Species with no ortholog for YTHDC2:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for YTHDC2 Gene

Gene Tree for YTHDC2 (if available)
Gene Tree for YTHDC2 (if available)

Paralogs for YTHDC2 Gene

Paralogs for YTHDC2 Gene

Selected SIMAP similar genes for YTHDC2 Gene using alignment to 4 proteins:

genes like me logo Genes that share paralogs with YTHDC2: view

Variants for YTHDC2 Gene

Sequence variations from dbSNP and Humsavar for YTHDC2 Gene

SNP ID Clin Chr 05 pos Sequence Context AA Info Type MAF
rs9552 -- 113,593,997(+) ATAGT(A/G)TGTGC utr-variant-3-prime, nc-transcript-variant
rs919304 -- 113,580,701(-) ATCCC(A/G)GACAG intron-variant
rs929774 -- 113,513,781(-) GCCTG(C/T)GTTGG utr-variant-5-prime, nc-transcript-variant
rs957777 -- 113,512,957(-) AAGAA(A/G)TATCT upstream-variant-2KB
rs1035408 -- 113,515,424(-) GAAAC(A/G)TTTCT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for YTHDC2 Gene

Variant ID Type Subtype PubMed ID
dgv6295n71 CNV Loss 21882294
nsv882721 CNV Gain 21882294
nsv882722 CNV Loss 21882294
nsv882724 CNV Loss 21882294
esv2540445 CNV Deletion 19546169
esv2162364 CNV Deletion 18987734
esv2730604 CNV Deletion 23290073
esv1743798 CNV Deletion 17803354
dgv208n6 CNV Loss 16902084
nsv520674 CNV Gain 19592680
esv2752057 CNV Gain 17911159
esv2730605 CNV Deletion 23290073
esv2730606 CNV Deletion 23290073
esv2730608 CNV Deletion 23290073
dgv1000e201 CNV Deletion 23290073

Relevant External Links for YTHDC2 Gene

HapMap Linkage Disequilibrium report
Human Gene Mutation Database (HGMD)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for YTHDC2 Gene

Disorders for YTHDC2 Gene

Relevant External Links for YTHDC2

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator
genes like me logo Genes that share disorders with YTHDC2: view

No data available for UniProtKB/Swiss-Prot for YTHDC2 Gene

Publications for YTHDC2 Gene

  1. Genome-wide association study identifies genetic variants influencing F-cell levels in sickle-cell patients. (PMID: 21326311) Bhatnagar P. … Keefer J.R. (J. Hum. Genet. 2011) 3 48
  2. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg R.L. … Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002) 2 3
  3. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4
  4. Large-scale characterization of HeLa cell nuclear phosphoproteins. (PMID: 15302935) Beausoleil S.A. … Gygi S.P. (Proc. Natl. Acad. Sci. U.S.A. 2004) 3
  5. Transcriptome analysis of human gastric cancer. (PMID: 16341674) Oh J.H. … Kim N.S. (Mamm. Genome 2005) 3

Products for YTHDC2 Gene

Sources for YTHDC2 Gene

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