YSK4 Gene
protein-coding GIFtS : 47
GC02M135438
YSK4 Sps1/Ste20-related kinase homolog (S. cerevisiae) (Previous names: Yeast Sps1/Ste20-related kinase 4 (S. cerevisiae), yeast Sps1/Ste20-related kinase 4 (S. cerevisiae) )Symbol approved by the HUGO Gene Nomenclature Committee (HGNC) database
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Aliases & Descriptions for YSK4
(According to
1 HGNC ,
2 Entrez Gene ,
3 UniProtKB/Swiss-Prot ,
4 UniProtKB/TrEMBL , 5 OMIM , 6 GeneLoc
, and/or 7 Ensembl ,
8 miRBase )About This Section
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Aliases EC 2.7.11.1 3 FLJ23074 1 , 2 RCK 2 , 3
Descriptions Regulated in COPD, protein kinase 3 YSK4 Sps1/Ste20-related kinase homolog (S. cerevisiae) 2 regulated in COPD kinase 2 yeast Sps1/Ste20-related kinase 4 2 yeast Sps1/Ste20-related kinase 4 (S. cerevisiae) 1
Search outside databases for aliases for YSK4 genePrevious GC identifer: GC02M135571
Summaries for YSK4 (According to Entrez Gene ,
Wikipedia's
Gene Wiki ,
UniProtKB/Swiss-Prot ,
and/or
UniProtKB/TrEMBL )
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Genomic Location for YSK4
(According to
GeneLoc and/or
HGNC , and/or
Entrez Gene (NCBI build 36) ,
and/or miRBase ,
Genomic Views according to
UCSC and
Ensembl ,
Transcription factor binding sites according to
SABiosciences )About This Section
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Genomic View : UCSC Golden Path with GeneCards custom track Transcription factor binding sites upstream to the YSK4 gene Entrez Gene cytogenetic band: 2q21.3 Ensembl cytogenetic band: 2q21.3 HGNC cytogenetic band: 2q21.3 YSK4 Gene in genomic location: bands according to Ensembl, locations according to
(and/or Entrez Gene and/or Ensembl if different) GeneLoc gene densities for chromosome 2 GeneLoc Exon Structure
GeneLoc location for GC02M135438:
(about GC identifiers )
Start:
135,438,743 bp from pter
End:
135,498,718 bp from pter
Size:
59,976 bases
Orientation:
minus strand
RefSeq DNA sequence: NC_000002.10 NT_022135.15 Proteins for YSK4
(According to
1 UniProtKB ,
and/or Ensembl ,
Phosphorylation sites according to 2 Phosphosite ,
RefSeq according to NCBI ,
PDB rendering according to OCA and/or Proteopedia ,
Recombinant Proteins
from Invitrogen ,
Millipore ,
Sigma-Aldrich ,
R&D Systems ,
Enzo Life Sciences ,
Abnova ,
OriGene and/or,
Abcam ,
Biochemical Assays by
Invitrogen ,
Millipore ,
R&D Systems ,
Cell Signaling Technology , and/or
Enzo Life Sciences ,
Ontologies according to Gene
Ontology Consortium 01 Apr 2009 and
Entrez Gene ,
Antibodies by Invitrogen ,
Millipore ,
Sigma-Aldrich ,
R&D Systems ,
Cell Signaling Technology ,
Abcam ,
Abnova , and/or
Novus Biologicals )
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UniProtKB/Swiss-Prot: YSK4_HUMAN, Q56UN5 (See
protein sequence )Recommended Name: SPS1/STE20-related protein kinase YSK4 Size : 1328 amino acids; 150537 Da
Secondary accessions : B2RP57 Q56UN1 Q56UN2 Q56UN3 Q56UN4 Q8N4E9 Q9H5T2Alternative splicing : 6 isoforms : Q56UN5-1 Q56UN5-2 Q56UN5-3 Q56UN5-4 Q56UN5-5 Q56UN5-6
Post-translational modifications:
View phosphorylation sites using PhosphoSite 2
REFSEQ proteins (2 alternative transcripts):
NP_001018056.1 NP_079328.3 ENSEMBL proteins: ENSP00000365005 ENSP00000351140 ENSP00000365004 ENSP00000376650 ENSP00000376649 ENSP00000321160 ENSP00000376647 Human Recombinant Proteins Browse Origene for full length recombinant human proteins expressed in human HEK293 cells Antibodies for YSK4: Assays for YSK4:
Protein
Domains/ Families for YSK4(According to InterPro , ProtoNet ,
UniProtKB , and/or BLOCKS ,
Sets of similar genes according to GeneDecks )
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Graphical View of Domain Structure for InterPro Entry Q56UN5 ProtoNet protein and cluster: Q56UN5
UniProtKB/Swiss-Prot: YSK4_HUMAN, Q56UN5 Similarity : Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. STE20subfamily Similarity : Contains 1 protein kinase domain
Gene Function for YSK4
(According to MGI Jun 06 2009, UniProtKB ,
IUBMB ,and/or Genatlas ,
shRNA from
OriGene ,
Sigma-Aldrich , RNAi from
Sigma-Aldrich ,
RNAi Products ,
Clones , and
Q-PCR Products
from Invitrogen ,
Millipore ,
OriGene , and/or
Abnova ,
siRNAs from
Applied Biosystems ,
SYBR primers from OriGene ,
Cell-based Assays from Millipore ,
Ontologies according to Gene Ontology Consortium 01 Apr 2009 via
Entrez Gene .)
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               OriGene 29mer shRNA kit in GFP-retroviral vectors (see all 2 ): NM_025052 Applied Biosystems Silencer ® siRNAs for YSK4 Sigma-Aldrich siRNA and siRNA Panels for YSK4 Sigma-Aldrich shRNA Panels and shRNA for YSK4 Explore Sigma-Aldrich super-pooled esiRNAs                OriGene GFP tagged cDNA clones in CMV expression vector (see all 2 ): NM_001018046                                  Myc/DDK tagged cDNA clones in CMV expression vector (see all 2 ): NM_001018046                                  untagged cDNA clones in CMV expression vector (see all 2 ): NM_001018046  Primers: Browse
Quantitative PCR Central at Invitrogen for Q-PCR LUX™ Primers               OriGene genome-wide validated SYBR primer pairs: NM_025052 UniProtKB/Swiss-Prot: YSK4_HUMAN, Q56UN5 Catalytic activity : ATP + a protein = ADP + a phosphoproteinEnzyme Number (IUBMB): EC 2.7.11.1
4 Gene Ontology (GO) molecular function terms (links to tree view) :
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Pathways & Interactions for YSK4
(Pathways according to Invitrogen
(maps by GeneGo ),
Millipore ,
Cell Signaling Technology ,
Sigma-Aldrich ,
KEGG
and/or UniProtKB ,
Sets of similar genes according to GeneDecks ,
Proteins Network according to
SABiosciences ,
Interactions according to 1 UniProtKB ,
2 MINT , and/or
3 STRING ,
with links to IntAct and
Ensembl ,
Ontologies according to Gene Ontology Consortium 01 Apr 2009 via
Entrez Gene .)
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--1 Gene Ontology (GO) biological process term (links to tree view) :
GO ID Qualified GO term Evidence PubMed IDs GO:0006468 protein amino acid phosphorylation
IEA --
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Drugs & Compounds for YSK4 (Chemical Compounds according to UniProtKB , Enzo Life Sciences ,
Sigma-Aldrich , Tocris Bioscience , and/or
Novoseek and Drugs according to
Enzo Life Sciences and/or
PharmGKB )
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Browse Tocris compounds for YSK4
Transcripts for YSK4(GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 219 Homo sapiens; Jun 2 2009) or GenBank , RefSeq according to Entrez Gene ,
DOTS (version 10), and/or
AceView ,
non coding RNAs according to
RNAdb ,
ESTs according to GeneTide ,
exon structure from GeneLoc ,
alternative splicing isoforms according to ASD and/or
ECgene ,
RNAi Products from Invitrogen ,
Millipore , and/or
Abnova ,
siRNAs from Applied Biosystems ,
Sigma-Aldrich ,
shRNA from
Sigma-Aldrich ,
OriGene ,
Tagged/untagged cDNA clones from
OriGene , Expression Assays from Applied Biosystems )About This Section
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               OriGene 29mer shRNA kit in GFP-retroviral vectors (see all 2 ): NM_025052 Sigma-Aldrich siRNA and siRNA Panels for YSK4 Sigma-Aldrich shRNA Panels and shRNA for YSK4 Explore Sigma-Aldrich super-pooled esiRNAs
Applied Biosystems Silencer ® siRNAs: NM_001018046 NM_025052
REFSEQ mRNAs for YSK4 gene (2 alternative transcripts): NM_001018046.1 NM_025052.3
Applied Biosystems TaqMan ® Gene Expression Assays: NM_001018046 NM_025052
               OriGene GFP tagged cDNA clones in CMV expression vector (see all 2 ): NM_001018046                                  Myc/DDK tagged cDNA clones in CMV expression vector (see all 2 ): NM_001018046                                  untagged cDNA clones in CMV expression vector (see all 2 ): NM_001018046  
Additional cDNA sequence: AK122935.1 AK131216.1 AK225579.1 AK309454.1 AY574901.1 AY574902.1 AY574903.1 AY574904.1 AY574905.1 BC034417.1 BC137276.1 BC137277.1 BC144555.1
9 DOTS entries : DT.91917990 DT.403574 DT.121021305 DT.102825058 DT.121021292 DT.99996939 DT.97790639 DT.121021293 DT.121021303
24/25 AceView cDNA sequences (see all 25
):BM969829 BQ045211 BC034417 AK131216 CA311871 AK122935 CD632388 CD632400 N57475 AK097522 CD632386 NM_025052 AK026727 BI832332 CD632385 CD632396 CD632398 CD632394 CD632402 BX090530 CD632392 N47620 CD632390 BU676900
highest scoring ESTs for YSK4 :AY574901 AY574902 AY574904 AY574905 BC034417 BM969829 BQ045211 N57475 NM_025052 AI683447
Unigene Cluster for YSK4: YSK4 Sps1/Ste20-related kinase homolog (S. cerevisiae) Hs.659395 [show with all ESTs ] Unigene Representative Sequence: AK122935 GeneLoc Exon Structure 5/6 Alternative Splicing Database (ASD) splice patterns (SP) for YSK4 (see all 6
) ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9a · 9b ^ 10a · 10b ^ 11a · 11b · 11c · 11d · 11e SP1 :                     -               SP2 :   -                   -   -             SP3 :   -             -     -   -   -   -           SP4 :   -             -       -   -             SP5 :   -       -   -           -   -            
About this scheme ECgene alternative splicing isoforms for YSK4 7 Ensembl transcripts including schematic representations : ENST00000375845
ENST00000358371
ENST00000375844
ENST00000392918
ENST00000392917
ENST00000315513
ENST00000392915
Expression for YSK4
(Experimental results according to
1 GeneNote
and GNF BioGPS ,
probe sets-to-genes annotations according to
2 GeneAnnot ,
3 GeneTide ,
Sets of similar genes according to GeneDecks ,
Electronic Northern calculations according to data from
UniGene (Build 219 Homo sapiens),
SAGE tags according to
CGAP ,
plus additional links to
SOURCE , and/or
GNF
BioGPS , and/or
EXPOLDB , and/or
UniProtKB ,
Expression Assays from
Applied Biosystems
)
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YSK4 expression in normal and diseased human tissues Applied Biosystems TaqMan ® Gene Expression Assays for YSK4 1 / 2 / 3
4 probe-sets matching YSK4 gene Data from
(Publications) and GNF BioGPS About these images About these images CGAP SAGE TAG: TGCCTGACCASOURCE GeneReport for Unigene cluster: Hs.659395
Orthologs for YSK4
(Orthologs according to
1,2 HomoloGene (2 older version, for species not in 1 newer version),
3 euGenes ,
4 SGD
and/or
5 MGI Jun 06 2009,
with possible further links to
Flybase
and/or
WormBase ,
Gene Trees according to Ensembl )
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Orthologs for YSK4 gene from 5/7 species (see all 7
)
About this table Species with no ortholog for YSK4 ENSEMBL Gene Tree for YSK4 Paralogs for YSK4 (Paralogs according to 1 HomoloGene and 2 Ensembl , Pseudogenes according to 3 Pseudogene.org )About This Section
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Paralogs for YSK4 gene MAP3K3 2 MAP3K2 2
SNPs/Variants for YSK4 (According to the
1 NCBI SNP Database ,
2 Ensembl ,
3 PupaSUITE , and
UniProtKB ,
Linkage Disequilibrium by HapMap ,
Genotyping Reagents from
Applied Biosystems )
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HapMap Linkage Disequilibrium images for YSK4 (up to first 250kb)
Disorders & Mutations for YSK4
(in which this Gene is Involved, According to
OMIM, UniProtKB ,
PharmGKB ,
Genatlas , GeneTests ,
Blood group antigen gene mutations by BGMUT ,
HGMD, GAD ,
HuGE Navigator ,
BCGD ,
and/or TGDB .)
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Medical News for YSK4 (Possibly Related Articles in
Doctor's Guide )
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Publications for YSK4 (in
PubMed .
Associations of this gene to articles via
1 Novoseek ,
2 HGNC ,
3 Entrez Gene ,
4 UniProtKB/Swiss-Prot ,
5 UniProtKB/TrEMBL ,
6 GAD , and/or
7 PharmGKB )
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6 PubMed articles for YSK4 gene :
Search for YSK4
(in PubMed ,
OMIM , and NCBI Bookshelf ) About This Section
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Genome Databases showing YSK4
(According to
Entrez Gene ,
HGNC ,
AceView ,
euGenes ,
Ensembl ,
miRBase ,
ECgene ,
and/or
H-InvDB )
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Other Databases showing YSK4
(According to HUGE )
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Specialized Databases showing YSK4 (According to ATLAS , HORDE , IMGT , MTDB, LEIDEN , UniProtKB/Swiss-Prot , and/or UniProtKB/TrEMBL ,Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot )About This Section
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-- Services for YSK4 (Reagents available from Applied Biosystems , Antibodies and assays by Cell
Signaling Technology , Abcam , Novus Biologicals ,Sigma-Aldrich , R&D Systems , Millipore , Abnova , and/or Invitrogen , Clones available from OriGene ,and/or Invitrogen , Drugs and/or compounds by Sigma-Aldrich , Enzo Life Sciences , and/or Tocris Bioscience )About This Section
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