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Aliases for YRDC Gene

Aliases for YRDC Gene

  • YrdC N(6)-Threonylcarbamoyltransferase Domain Containing 2 3
  • IRIP 3 4 6
  • Ischemia/Reperfusion-Inducible Protein Homolog 3 4
  • Dopamine Receptor-Interacting Protein 3 3 4
  • Ischemia/Reperfusion Inducible Protein 2 3
  • HIRIP 3 4
  • DRIP3 3 4
  • YrdC Domain-Containing Protein, Mitochondrial 3
  • Dopamine Receptor Interacting Protein 3 3
  • YrdC Domain Containing (E. Coli) 2
  • YrdC Domain Containing (E.Coli) 2
  • YrdC Domain Containing 3
  • SUA5 3

External Ids for YRDC Gene

Previous GeneCards Identifiers for YRDC Gene

  • GC01M037938
  • GC01M038041
  • GC01M038268
  • GC01M036386

Summaries for YRDC Gene

GeneCards Summary for YRDC Gene

YRDC (YrdC N(6)-Threonylcarbamoyltransferase Domain Containing) is a Protein Coding gene. Diseases associated with YRDC include ischemia. GO annotations related to this gene include double-stranded RNA binding.

UniProtKB/Swiss-Prot for YRDC Gene

  • May regulate the activity of some transporters.

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for YRDC Gene

Genomics for YRDC Gene

Regulatory Elements for YRDC Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for YRDC Gene

37,802,942 bp from pter
37,808,193 bp from pter
5,252 bases
Minus strand

Genomic View for YRDC Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for YRDC Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for YRDC Gene

Proteins for YRDC Gene

  • Protein details for YRDC Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    YrdC domain-containing protein, mitochondrial
    Protein Accession:
    Secondary Accessions:
    • Q4W4X8
    • Q6NVW3
    • Q7L4E4
    • Q7Z2I4
    • Q9H5F8

    Protein attributes for YRDC Gene

    279 amino acids
    Molecular mass:
    29328 Da
    Quaternary structure:
    • Interacts with RSC1A1.
    • Sequence=AAH08984.3; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=AAP37053.1; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=AAP37054.1; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=BAB15668.1; Type=Erroneous initiation; Evidence={ECO:0000305};

neXtProt entry for YRDC Gene

Proteomics data for YRDC Gene at MOPED

Post-translational modifications for YRDC Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for YRDC Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for YRDC Gene

Domains for YRDC Gene

Suggested Antigen Peptide Sequences for YRDC Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Contains 1 YrdC-like domain.
  • Belongs to the SUA5 family.
  • Contains 1 YrdC-like domain.
  • Belongs to the SUA5 family.
genes like me logo Genes that share domains with YRDC: view

No data available for Gene Families for YRDC Gene

Function for YRDC Gene

Molecular function for YRDC Gene

UniProtKB/Swiss-Prot Function:
May regulate the activity of some transporters.

Gene Ontology (GO) - Molecular Function for YRDC Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003725 double-stranded RNA binding IEA --
GO:0005515 protein binding --
genes like me logo Genes that share ontologies with YRDC: view

Phenotypes for YRDC Gene

GenomeRNAi human phenotypes for YRDC:
genes like me logo Genes that share phenotypes with YRDC: view

Animal Model Products

No data available for Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targeting and HOMER Transcription for YRDC Gene

Localization for YRDC Gene

Subcellular locations from UniProtKB/Swiss-Prot for YRDC Gene

Mitochondrion. Membrane; Peripheral membrane protein. Note=Predominantly localized in the plasma membrane. {ECO:0000250}.

Subcellular locations from

Jensen Localization Image for YRDC Gene COMPARTMENTS Subcellular localization image for YRDC gene
Compartment Confidence
mitochondrion 3
cytosol 1
extracellular 1
nucleus 1

Gene Ontology (GO) - Cellular Components for YRDC Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005739 mitochondrion IEA --
GO:0016020 membrane IEA --
genes like me logo Genes that share ontologies with YRDC: view

Pathways for YRDC Gene

SuperPathways for YRDC Gene

No Data Available

PCR Array Products

  • Pathway & Disease-focused RT² Profiler PCR Arrays

Gene Ontology (GO) - Biological Process for YRDC Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0051051 negative regulation of transport IDA 2675563
genes like me logo Genes that share ontologies with YRDC: view

No data available for Pathways by source for YRDC Gene

Transcripts for YRDC Gene

mRNA/cDNA for YRDC Gene

(1) REFSEQ mRNAs :
(11) Additional mRNA sequences :
(144) Selected AceView cDNA sequences:
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for YRDC Gene

YrdC domain containing (E. coli):
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for YRDC Gene

No ASD Table

Relevant External Links for YRDC Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for YRDC Gene

mRNA expression in normal human tissues for YRDC Gene

Protein differential expression in normal tissues for YRDC Gene

This gene is overexpressed in Cervix (38.1), Testis (13.4), and Fetal ovary (8.0).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for YRDC Gene

SOURCE GeneReport for Unigene cluster for YRDC Gene Hs.301564

mRNA Expression by UniProt/SwissProt for YRDC Gene

Tissue specificity: Ubiquitously expressed.
genes like me logo Genes that share expressions with YRDC: view

Expression partners for YRDC Gene

* - Elite partner

Primer Products

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and mRNA differential expression in normal tissues for YRDC Gene

Orthologs for YRDC Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for YRDC Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia YRDC 35
  • 89.13 (n)
  • 90.84 (a)
  • 90 (a)
(Canis familiaris)
Mammalia YRDC 35
  • 86.49 (n)
  • 87.73 (a)
  • 86 (a)
(Mus musculus)
Mammalia Yrdc 35
  • 85.68 (n)
  • 86.28 (a)
Yrdc 16
Yrdc 36
  • 85 (a)
(Pan troglodytes)
Mammalia YRDC 35
  • 99.4 (n)
  • 99.64 (a)
  • 100 (a)
(Rattus norvegicus)
Mammalia Yrdc 35
  • 85.2 (n)
  • 87 (a)
(Monodelphis domestica)
Mammalia YRDC 36
  • 66 (a)
(Ornithorhynchus anatinus)
Mammalia YRDC 36
  • 70 (a)
(Gallus gallus)
Aves YRDC 35
  • 68.13 (n)
  • 67.6 (a)
  • 65 (a)
(Anolis carolinensis)
Reptilia YRDC 36
  • 64 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia yrdc 35
  • 59.97 (n)
  • 63.76 (a)
African clawed frog
(Xenopus laevis)
Amphibia LOC398509 35
(Danio rerio)
Actinopterygii yrdc 35
  • 59.19 (n)
  • 60.99 (a)
yrdc 36
  • 52 (a)
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP007397 35
  • 54.06 (n)
  • 47.67 (a)
fruit fly
(Drosophila melanogaster)
Insecta CG33786 35
  • 53.64 (n)
  • 49.75 (a)
CG33786 36
  • 41 (a)
(Caenorhabditis elegans)
Secernentea Y48C3A.18 36
  • 38 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes SUA5 38
thale cress
(Arabidopsis thaliana)
eudicotyledons AT5G60590 35
  • 50.34 (n)
  • 47.96 (a)
(Oryza sativa)
Liliopsida Os03g0201600 35
  • 51.76 (n)
  • 47.2 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 35 (a)
Species with no ortholog for YRDC:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for YRDC Gene

Gene Tree for YRDC (if available)
Gene Tree for YRDC (if available)

Paralogs for YRDC Gene Pseudogenes for YRDC Gene

genes like me logo Genes that share paralogs with YRDC: view

No data available for Paralogs for YRDC Gene

Variants for YRDC Gene

Sequence variations from dbSNP and Humsavar for YRDC Gene

SNP ID Clin Chr 01 pos Sequence Context AA Info Type MAF
rs7686 -- 37,803,246(-) CTCGC(A/G)GGGAG utr-variant-3-prime
rs10015 -- 37,802,983(-) TTTTT(C/T)TTTAA utr-variant-3-prime
rs12395 -- 37,803,164(-) GGGAA(A/G)TAAAC utr-variant-3-prime
rs14614 -- 37,803,125(-) TTTTC(C/T)TATTT utr-variant-3-prime
rs540924 -- 37,805,518(-) GTCTT(C/T)CTTGG intron-variant

Structural Variations from Database of Genomic Variants (DGV) for YRDC Gene

Variant ID Type Subtype PubMed ID
nsv871810 CNV Loss 21882294
nsv870730 CNV Gain 21882294

Relevant External Links for YRDC Gene

HapMap Linkage Disequilibrium report

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for YRDC Gene

Disorders for YRDC Gene

MalaCards: The human disease database

MalaCards: The human disease database.

Search for YRDC Gene in MalaCards »

(1) Disease for YRDC Gene

genes like me logo Genes that share disorders with YRDC: view

No data available for OMIM , UniProtKB/Swiss-Prot , University of Copenhagen DISEASES , Novoseek inferred disease relationships , Genatlas and External Links for YRDC Gene

Publications for YRDC Gene

  1. Isolation and identification of a novel cDNA that encodes human yrdC protein. (PMID: 12730717) Chen J. … Mao Y. (J. Hum. Genet. 2003) 2 3 4
  2. IRIP, a new ischemia/reperfusion-inducible protein that participates in the regulation of transporter activity. (PMID: 16024787) Jiang W. … Mirochnitchenko O. (Mol. Cell. Biol. 2005) 3 4
  3. Large-scale analysis of the human ubiquitin-related proteome. (PMID: 16196087) Matsumoto M. … Nakayama K.I. (Proteomics 2005) 3
  4. Systematic analysis of the protein interaction network for the human transcription machinery reveals the identity of the 7SK capping enzyme. (PMID: 17643375) Jeronimo C. … Coulombe B. (Mol. Cell 2007) 3
  5. Ischemia-reperfusion-inducible protein modulates cell sensitivity to anticancer drugs by regulating activity of efflux transporter. (PMID: 19279227) Prokopenko O. … Mirochnitchenko O. (Am. J. Physiol., Cell Physiol. 2009) 3

Products for YRDC Gene

Sources for YRDC Gene

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