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Aliases for YRDC Gene

Aliases for YRDC Gene

  • YrdC N6-Threonylcarbamoyltransferase Domain Containing 2 3
  • YrdC N(6)-Threonylcarbamoyltransferase Domain Containing 3 5
  • Ischemia/Reperfusion-Inducible Protein Homolog 3 4
  • Dopamine Receptor-Interacting Protein 3 3 4
  • Ischemia/Reperfusion Inducible Protein 2 3
  • HIRIP 3 4
  • DRIP3 3 4
  • IRIP 3 4
  • Dopamine Receptor Interacting Protein 3 3
  • YrdC Domain Containing (E. Coli) 2
  • YrdC Domain Containing (E.Coli) 2
  • YrdC Domain Containing 3
  • SUA5 3

External Ids for YRDC Gene

Previous GeneCards Identifiers for YRDC Gene

  • GC01M037938
  • GC01M038041
  • GC01M038268
  • GC01M036386

Summaries for YRDC Gene

GeneCards Summary for YRDC Gene

YRDC (YrdC N6-Threonylcarbamoyltransferase Domain Containing) is a Protein Coding gene. GO annotations related to this gene include double-stranded RNA binding.

UniProtKB/Swiss-Prot for YRDC Gene

  • May regulate the activity of some transporters.

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for YRDC Gene

Genomics for YRDC Gene

Regulatory Elements for YRDC Gene

Enhancers for YRDC Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around YRDC on UCSC Golden Path with GeneCards custom track

Promoters for YRDC Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around YRDC on UCSC Golden Path with GeneCards custom track

Genomic Location for YRDC Gene

Chromosome:
1
Start:
37,802,942 bp from pter
End:
37,808,193 bp from pter
Size:
5,252 bases
Orientation:
Minus strand

Genomic View for YRDC Gene

Genes around YRDC on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
YRDC Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for YRDC Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for YRDC Gene

Proteins for YRDC Gene

  • Protein details for YRDC Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q86U90-YRDC_HUMAN
    Recommended name:
    YrdC domain-containing protein, mitochondrial
    Protein Accession:
    Q86U90
    Secondary Accessions:
    • Q4W4X8
    • Q6NVW3
    • Q7L4E4
    • Q7Z2I4
    • Q9H5F8

    Protein attributes for YRDC Gene

    Size:
    279 amino acids
    Molecular mass:
    29328 Da
    Quaternary structure:
    • Interacts with RSC1A1.
    SequenceCaution:
    • Sequence=AAH08984.3; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=AAP37053.1; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=AAP37054.1; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=BAB15668.1; Type=Erroneous initiation; Evidence={ECO:0000305};

neXtProt entry for YRDC Gene

Proteomics data for YRDC Gene at MOPED

Post-translational modifications for YRDC Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for YRDC Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for YRDC Gene

Domains & Families for YRDC Gene

Suggested Antigen Peptide Sequences for YRDC Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q86U90

UniProtKB/Swiss-Prot:

YRDC_HUMAN :
  • Contains 1 YrdC-like domain.
  • Belongs to the SUA5 family.
Domain:
  • Contains 1 YrdC-like domain.
Family:
  • Belongs to the SUA5 family.
genes like me logo Genes that share domains with YRDC: view

No data available for Gene Families for YRDC Gene

Function for YRDC Gene

Molecular function for YRDC Gene

UniProtKB/Swiss-Prot Function:
May regulate the activity of some transporters.

Gene Ontology (GO) - Molecular Function for YRDC Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IEA --
genes like me logo Genes that share ontologies with YRDC: view
genes like me logo Genes that share phenotypes with YRDC: view

Animal Model Products

miRNA for YRDC Gene

miRTarBase miRNAs that target YRDC

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for YRDC Gene

Localization for YRDC Gene

Subcellular locations from UniProtKB/Swiss-Prot for YRDC Gene

Mitochondrion. Membrane; Peripheral membrane protein. Note=Predominantly localized in the plasma membrane. {ECO:0000250}.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for YRDC Gene COMPARTMENTS Subcellular localization image for YRDC gene
Compartment Confidence
mitochondrion 5
cytosol 1
extracellular 1
nucleus 1

No data available for Gene Ontology (GO) - Cellular Components for YRDC Gene

Pathways & Interactions for YRDC Gene

SuperPathways for YRDC Gene

No Data Available

Gene Ontology (GO) - Biological Process for YRDC Gene

None

No data available for Pathways by source and SIGNOR curated interactions for YRDC Gene

Drugs & Compounds for YRDC Gene

No Compound Related Data Available

Transcripts for YRDC Gene

mRNA/cDNA for YRDC Gene

(1) REFSEQ mRNAs :
(11) Additional mRNA sequences :
(144) Selected AceView cDNA sequences:
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for YRDC Gene

YrdC domain containing (E. coli):
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for YRDC Gene

No ASD Table

Relevant External Links for YRDC Gene

GeneLoc Exon Structure for
YRDC
ECgene alternative splicing isoforms for
YRDC

Expression for YRDC Gene

mRNA expression in normal human tissues for YRDC Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for YRDC Gene

This gene is overexpressed in Cervix (38.1), Testis (13.4), and Fetal ovary (8.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for YRDC Gene



SOURCE GeneReport for Unigene cluster for YRDC Gene Hs.301564

mRNA Expression by UniProt/SwissProt for YRDC Gene

Q86U90-YRDC_HUMAN
Tissue specificity: Ubiquitously expressed.
genes like me logo Genes that share expression patterns with YRDC: view

Protein tissue co-expression partners for YRDC Gene

Primer Products

No data available for mRNA differential expression in normal tissues for YRDC Gene

Orthologs for YRDC Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for YRDC Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia YRDC 35
  • 89.13 (n)
  • 90.84 (a)
YRDC 36
  • 90 (a)
OneToOne
dog
(Canis familiaris)
Mammalia YRDC 35
  • 86.49 (n)
  • 87.73 (a)
YRDC 36
  • 86 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Yrdc 35
  • 85.68 (n)
  • 86.28 (a)
Yrdc 16
Yrdc 36
  • 85 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia YRDC 35
  • 99.4 (n)
  • 99.64 (a)
YRDC 36
  • 100 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Yrdc 35
  • 85.2 (n)
  • 87 (a)
oppossum
(Monodelphis domestica)
Mammalia YRDC 36
  • 66 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia YRDC 36
  • 70 (a)
OneToOne
chicken
(Gallus gallus)
Aves YRDC 35
  • 68.13 (n)
  • 67.6 (a)
YRDC 36
  • 65 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia YRDC 36
  • 64 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia yrdc 35
  • 59.97 (n)
  • 63.76 (a)
African clawed frog
(Xenopus laevis)
Amphibia LOC398509 35
zebrafish
(Danio rerio)
Actinopterygii yrdc 35
  • 59.19 (n)
  • 60.99 (a)
yrdc 36
  • 52 (a)
OneToOne
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP007397 35
  • 54.06 (n)
  • 47.67 (a)
fruit fly
(Drosophila melanogaster)
Insecta CG33786 35
  • 53.64 (n)
  • 49.75 (a)
CG33786 36
  • 41 (a)
OneToOne
worm
(Caenorhabditis elegans)
Secernentea Y48C3A.18 36
  • 38 (a)
OneToOne
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes SUA5 38
thale cress
(Arabidopsis thaliana)
eudicotyledons AT5G60590 35
  • 50.34 (n)
  • 47.96 (a)
rice
(Oryza sativa)
Liliopsida Os03g0201600 35
  • 51.76 (n)
  • 47.2 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 35 (a)
OneToOne
Species with no ortholog for YRDC:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for YRDC Gene

ENSEMBL:
Gene Tree for YRDC (if available)
TreeFam:
Gene Tree for YRDC (if available)

Paralogs for YRDC Gene

Pseudogenes.org Pseudogenes for YRDC Gene

genes like me logo Genes that share paralogs with YRDC: view

No data available for Paralogs for YRDC Gene

Variants for YRDC Gene

Sequence variations from dbSNP and Humsavar for YRDC Gene

SNP ID Clin Chr 01 pos Sequence Context AA Info Type
rs7686 -- 37,803,246(-) CTCGC(A/G)GGGAG utr-variant-3-prime
rs10015 -- 37,802,983(+) TTTTT(A/C/G/T)TTTAA utr-variant-3-prime
rs12395 -- 37,803,164(-) GGGAA(A/G)TAAAC utr-variant-3-prime
rs14614 -- 37,803,125(-) TTTTC(C/T)TATTT utr-variant-3-prime
rs540924 -- 37,805,518(-) GTCTT(C/T)CTTGG intron-variant

Structural Variations from Database of Genomic Variants (DGV) for YRDC Gene

Variant ID Type Subtype PubMed ID
nsv871810 CNV Loss 21882294
nsv870730 CNV Gain 21882294

Variation tolerance for YRDC Gene

Residual Variation Intolerance Score: 41.6% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.03; 21.10% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for YRDC Gene

HapMap Linkage Disequilibrium report
YRDC

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for YRDC Gene

Disorders for YRDC Gene

Relevant External Links for YRDC

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
YRDC

No disorders were found for YRDC Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for YRDC Gene

Publications for YRDC Gene

  1. Isolation and identification of a novel cDNA that encodes human yrdC protein. (PMID: 12730717) Chen J. … Mao Y. (J. Hum. Genet. 2003) 2 3 4 67
  2. SR protein kinases promote splicing of nonconsensus introns. (PMID: 26167880) Lipp J.J. … Guthrie C. (Nat. Struct. Mol. Biol. 2015) 3
  3. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 3
  4. A census of human soluble protein complexes. (PMID: 22939629) Havugimana P.C. … Emili A. (Cell 2012) 3
  5. Ischemia-reperfusion-inducible protein modulates cell sensitivity to anticancer drugs by regulating activity of efflux transporter. (PMID: 19279227) Prokopenko O. … Mirochnitchenko O. (Am. J. Physiol., Cell Physiol. 2009) 3

Products for YRDC Gene

Sources for YRDC Gene

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