YRDC Gene
protein-coding GIFtS: 45
GCID: GC01M038268
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yrdC domain containing (E. coli)(Previous name: yrdC domain containing (E.coli) )
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Aliases
for YRDC gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| YrdC Domain Containing (E. Coli)1 2 | | FLJ234761 | | IRIP1 2 3 5 | | YrdC Domain Containing (E.Coli)1 | | SUA51 2 | | RP11-109P14.42 | | Dopamine Receptor-Interacting Protein 32 3 | | Dopamine Receptor Interacting Protein 32 | | Ischemia/Reperfusion-Inducible Protein Homolog2 3 | | Ischemia/Reperfusion Inducible Protein2 | | DRIP32 3 | | YrdC Domain-Containing Protein, Mitochondrial2 | | HIRIP1 | | |
Export aliases for YRDC gene to outside databasesPrevious GC identifers: GC01M037938 GC01M038041 GC01M036386 |
Summaries
for YRDC gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
UniProtKB/Swiss-Prot: YRDC_HUMAN, Q86U90Function: May regulate the activity of some transporters (By similarity)
|
Genomic Views
for YRDC gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000001.10 NC_018912.1 NT_032977.9
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the YRDC gene promoter:
COUP-TF1 Pbx1a Pax-5 COUP HNF-4alpha2 CUTL1 LCR-F1 HNF-4alpha1 Ik-2 COUP-TF
Other transcription factors
Search SABiosciences Chromatin IP Primers for YRDC
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat YRDC |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 1p34.3 Ensembl cytogenetic band: 1p34.3 HGNC cytogenetic band: 1p34.3YRDC Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 1 GeneLoc Exon Structure GeneLoc location for GC01M038268: view genomic region
(about GC identifiers)
Start:
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38,268,614 bp from pter |
End:
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38,273,865 bp from pter |
Size:
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5,252 bases |
Orientation:
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minus strand |
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Proteins
for YRDC gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: YRDC_HUMAN, Q86U90 (See
protein sequence)Recommended Name: YrdC domain-containing protein, mitochondrial precursor Size: 279 amino acids; 29328 Da
Subunit: Interacts with RSC1A1 (By similarity)
Subcellular location: Mitochondrion (Potential). Membrane; Peripheral membrane protein. Note=Predominantly localized inthe plasma membrane (By similarity)
Sequence caution: Sequence=AAH08984.3; Type=Erroneous initiation; Sequence=AAP37053.1; Type=Erroneous initiation;Sequence=AAP37054.1; Type=Erroneous initiation; Sequence=BAB15668.1; Type=Erroneous initiation;
Secondary accessions: Q4W4X8 Q6NVW3 Q7L4E4 Q7Z2I4 Q9H5F8Explore the universe of human proteins at neXtProt for YRDC: NX_Q86U90
Post-translational modifications:
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_Q86U90
YRDC Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins: NP_078916.3
ENSEMBL proteins: ENSP00000362135
Human Recombinant Protein Products:
Gene Ontology (GO): 3 cellular component terms (GO ID links to tree view): About this table
YRDC for ontologies About GeneDecksing
YRDC Antibody Products:
Assay Products for YRDC: |
Protein
Domains /
Families
for YRDC gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
YRDC for domains About GeneDecksing
2 InterPro domains/families:Graphical View of Domain Structure for InterPro Entry Q86U90ProtoNet protein and cluster: Q86U90 2 Blocks protein families: IPB004388 Sua5/YciO/YrdC/YwlC protein family IPB006070 SUA5/yciO/yrdC
UniProtKB/Swiss-Prot: YRDC_HUMAN, Q86U90Similarity: Belongs to the SUA5 familySimilarity: Contains 1 YrdC-like domain |
Function
for YRDC gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Function Summary:
UniProtKB/Swiss-Prot: YRDC_HUMAN, Q86U90Function: May regulate the activity of some transporters (By similarity)
Clone
Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for YRDC (see all 4)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for YRDC (see all 2)
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
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| |  | GenScript: all cDNA clones in your preferred vector: YRDC (NM_024640) | |  | Browse Sino Biological Human cDNA Clones | |  | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for YRDC | |  | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat YRDC |
In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for YRDC |
Gene Ontology (GO): 1 molecular function term (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0005515 | protein binding |
-- | -- |
YRDC for ontologies About GeneDecksing
1 GenomeRNAi human phenotype for YRDC:
|
Pathways & Interactions
for YRDC gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Interactions:
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for YRDC
STRING Interaction
Network Preview (showing 3 interactants - click image to see more details)
3 Interacting proteins for YRDC (Q86U903 ENSP000003621354) via UniProtKB, MINT, STRING, and/or I2DAbout this table
Gene Ontology (GO): 1 biological process term (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0051051 | negative regulation of transport |
IDA | 2675563 |
YRDC for ontologies About GeneDecksing
|
Drugs & Compounds
for YRDC gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
 Browse Tocris compounds for YRDC
Search CenterWatch for drugs/clinical trials and news about YRDC
|
Transcripts
for YRDC gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for YRDC gene: NM_024640.3 Unigene Cluster for YRDC: YrdC domain containing (E. coli) Hs.301564 [show with all ESTs]Unigene Representative Sequence: AK0907701 Ensembl transcript including schematic representation, and UCSC links where relevant: ENST00000373044(uc001cca.1)
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for YRDC (see all 4)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for YRDC (see all 2)
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector: YRDC (NM_024640) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for YRDC | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat YRDC |
Additional cDNA sequence: AF250397.1 AK027129.1 AK090770.1 AK129676.1 AY172561.1 AY286019.1 AY286020.1 BC008984.1 BC067857.1 BC068057.1 BC080186.1 10 DOTS entries: DT.91922876 DT.91721077 DT.100757666 DT.100010010 DT.100701535 DT.95151122 DT.95151123 DT.100805326 DT.101960885 DT.91760838 24/144 AceView cDNA sequences (see all 144): AY172561 CR593798 BX339259 AI277012 F09604 AY286020 BU849788 CR612568 BG116662 F09318 AL514604 BC080186 BC068057 AK027129 BM127051 BU194354 CR615600 BX118773 AV714679 AW573003 BC008984 CR625266 AI304827 AA917670
GeneLoc Exon Structure
|
Expression
for YRDC gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| YRDC expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: TATTGTAATT
About this image
See YRDC Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for YRDC
SOURCE GeneReport for Unigene cluster: Hs.301564
UniProtKB/Swiss-Prot: YRDC_HUMAN, Q86U90Tissue specificity: Ubiquitously expressed
SABiosciences Expression via Pathway-Focused PCR Array including YRDC:
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for YRDC
Browse OriGene validated miRNA SYBR primer pairs
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse, rat YRDC | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat YRDC | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat YRDC | In Situ
Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for YRDC |
Orthologs
for YRDC gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the last universal common ancestor (LUCA).
Orthologs for YRDC gene from 10/35 species (see all 35) About this table
ENSEMBL Gene Tree for YRDC (if available)
TreeFam Gene Tree for YRDC (if available) |
Paralogs
for YRDC gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| Paralogs for YRDC gene
YRDC for paralogs About GeneDecksing
3 Pseudogenes.org Pseudogenes for YRDC
PGOHUM00000239180 PGOHUM00000236272 PGOHUM00000236724
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Genomic Variants
for YRDC gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 1 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for YRDC (38268614 - 38273865 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV) variations for YRDC: -- | SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing YRDC |
|
Disorders
/ Diseases
for YRDC gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
YRDC for disorders About GeneDecksing
OMIM gene information: 612276
OMIM disorders: --
5  diseases for YRDC: About MalaCardsischemia pneumonia tuberculosis malaria
mycobacterium tuberculosis
Export disorders for YRDC gene to outside databases
|
Publications
for YRDC gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for YRDC gene, integrated from 9 sources (see all 21):
(articles sorted by number of sources associating them with YRDC) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- Isolation and identification of a novel cDNA that encodes human yrdC protein. (PubMed id 12730717)1, 2, 3 Chen J.... Mao Y. (2003)
- IRIP, a new ischemia/reperfusion-inducible protein that participates in the regulation of transporter activity. (PubMed id 16024787)1, 2 Jiang W.... Mirochnitchenko O. (2005)
- A census of human soluble protein complexes. (PubMed id 22939629)1 Havugimana P.C....Emili A. (2012)
- Initial characterization of the human central proteome. (PubMed id 21269460)2 Burkard T.R.... Colinge J. (2011)
- Systematic and quantitative assessment of the ubiquiti n-modified proteome. (PubMed id 21906983)1 Kim W....Gygi S.P. (2011)
- System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation. (PubMed id 21406692)2 Rigbolt K.T....Blagoev B. (2011)
- Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis. (PubMed id 20068231)2 Olsen J.V....Mann M. (2010)
- Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions. (PubMed id 19690332)2 Mayya V.... Han D.K. (2009)
- Ischemia-reperfusion-inducible protein modulates cell sensitivity to anticancer drugs by regulating activity of efflux transporter. (PubMed id 19279227)1 Prokopenko O. and Mirochnitchenko O. (2009)
- Kinase-selective enrichment enables quantitative phosphoproteomics of the kinome across the cell cycle. (PubMed id 18691976)2 Daub H.... Mann M. (2008)
|
External Searches for YRDC gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
|
Genome Databases showing YRDC gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing YRDC gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing YRDC gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
| Name | Description |
| PharmGKB entry for YRDC | Pharmacogenomics, SNPs, Pathways |
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| | |
About This Section
| Patent Information for YRDC gene:
Search GeneIP for patents involving YRDC
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for YRDC gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
About This Section
|
 | |
 | |
 |
| | |  | Browse OriGene Antibodies | | OriGene shRNA RFP for YRDC | | | OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for YRDC | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for YRDC | | | Browse OriGene Protein Over-expression Lysates | | Browse OriGene Fluorogenic Cell Assay Kits | | | OriGene siRNA for YRDC | | OriGene 3'-UTR Clone for YRDC | | | OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for YRDC | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for YRDC | | | Browse OriGene GFP tagged cDNA clones in CMV expression vector | | Browse OriGene MicroRNA Expression Plasmids | | | Browse OriGene basic RS shRNAs | | Browse OriGene validated miRNA SYBR primer pairs | | | Browse OriGene full length recombinant human proteins expressed in human HEK293 cells | | OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling | | | OriGene Custom Antibody Services for YRDC | | OriGene Custom Protein Services for YRDC | | | OriGene Custom Immunoassay Development | | |
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| | | QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat YRDC | | | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing YRDC | | | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat YRDC | | | QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat YRDC | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat YRDC | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat YRDC |
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 |  |  |  | |
| | | | Search Tocris compounds for YRDC |
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 | | | YRDC Proteins, Antibodies, CLIAs, and ELISAs |
| | | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for YRDC |
|  |  |  | | | | Search ThermoFisher Antibodies for YRDC |
| | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat YRDC |
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