YPEL5 Gene
protein-coding GIFtS: 50
GCID: GC02P030369
|
|
yippee-like 5 (Drosophila)
| |
Aliases
for YPEL5 gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| Yippee-Like 5 (Drosophila)1 2 | | CGI-1271 | | Protein Yippee-Like 52 |
Export aliases for YPEL5 gene to outside databasesPrevious GC identifers: GC02P030345 GC02P030281 GC02P030223 GC02P030108 |
Summaries
for YPEL5 gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
-- |
Genomic Views
for YPEL5 gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000002.11 NC_018913.1 NT_022184.15
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the YPEL5 gene promoter:
FOXF2 FOXO3 POU6F1 (c2) STAT5A FOXO3b MZF-1 POU2F1a FOXO3a ATF6
Other transcription factors
Search SABiosciences Chromatin IP Primers for YPEL5
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat YPEL5 |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 2p23.1 Ensembl cytogenetic band: 2p23.1 HGNC cytogenetic band: 2p23YPEL5 Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 2 GeneLoc Exon Structure GeneLoc location for GC02P030369: view genomic region
(about GC identifiers)
Start:
|
30,369,750 bp from pter |
End:
|
30,383,399 bp from pter |
Size:
|
13,650 bases |
Orientation:
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plus strand |
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Proteins
for YPEL5 gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: YPEL5_HUMAN, P62699 (See
protein sequence)Recommended Name: Protein yippee-like 5 Size: 121 amino acids; 13842 Da
Secondary accessions: D6W568 Q65Z97 Q8R174 Q9D6M1 Q9UMX7 Q9Y3C9Explore the universe of human proteins at neXtProt for YPEL5: NX_P62699
Post-translational modifications:
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_P62699
YPEL5 Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins (4 alternative transcripts):
NP_001120871.1 NP_001120872.1 NP_001120873.1 NP_057145.1
ENSEMBL proteins: ENSP00000368835 ENSP00000368834 ENSP00000261353 ENSP00000383974 ENSP00000385278
Human Recombinant Protein Products for YPEL5:
YPEL5 Antibody Products:
Assay Products for YPEL5: |
Protein
Domains /
Families
for YPEL5 gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
YPEL5 for domains About GeneDecksing
1 InterPro domain/family:Graphical View of Domain Structure for InterPro Entry P62699ProtoNet protein and cluster: P62699 1 Blocks protein family: IPB004910 Yippee-like protein
UniProtKB/Swiss-Prot: YPEL5_HUMAN, P62699Similarity: Belongs to the yippee family |
Function
for YPEL5 gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
inGenious Targeting Laboratory,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase,
shRNA from
OriGene,
Sirion Biotech,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Sirion Biotech,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
Sirion Biotech,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Gene Ontology (GO): 1 molecular function term (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0008113 | peptide-methionine (S)-S-oxide reductase activity |
-- | -- |
YPEL5 for ontologies About GeneDecksing
Phenotypes:
1 GenomeRNAi human phenotype for YPEL5:
Animal Models:
Clone
Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for YPEL5 (see all 7)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for YPEL5 (see all 4)
OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling 
| |  | GenScript: all cDNA clones in your preferred vector (see all 4): YPEL5 (NM_016061) | |  | Browse Sino Biological Human cDNA Clones | |  | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for YPEL5 | |  | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat YPEL5 |
In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for YPEL5 |
|
Pathways & Interactions
for YPEL5 gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Interactions:
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for YPEL5
STRING Interaction
Network Preview (showing 3 interactants - click image to see more details)
4 Interacting proteins for YPEL5 (P626993 ENSP000002613534) via UniProtKB, MINT, STRING, and/or I2DAbout this table
|
Drugs & Compounds
for YPEL5 gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
 Browse Tocris compounds for YPEL5
Search CenterWatch for drugs/clinical trials and news about YPEL5
|
Transcripts
for YPEL5 gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
Sirion Biotech,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for YPEL5 gene (4 alternative transcripts): NM_001127399.1 NM_001127400.1 NM_001127401.1 NM_016061.2 Unigene Cluster for YPEL5: Yippee-like 5 (Drosophila) Hs.515890 [show with all ESTs]Unigene Representative Sequence: NM_00112740110 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000379520(uc002rna.4 uc002rnd.3) ENST00000379519(uc002rnb.4 uc002rnc.4 uc002rmz.4 uc010ezn.3)
ENST00000261353 ENST00000490211 ENST00000402003 ENST00000402708 ENST00000482474
ENST00000470120 ENST00000492439 ENST00000495673
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for YPEL5 (see all 7)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for YPEL5 (see all 4)
OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector (see all 4): YPEL5 (NM_016061) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for YPEL5 | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat YPEL5 |
Additional cDNA sequence: AB098739.1 AF135161.1 AF151885.1 AF172940.1 AK025730.1 AK307099.1 AK311404.1 BC000836.1 BC047237.1 23 DOTS entries: DT.319786 DT.100885434 DT.92448299 DT.100885436 DT.97767180 DT.91664542 DT.92448297 DT.92448301 DT.92448298 DT.120985340 DT.92448305 DT.95227142 DT.95369308 DT.120985374 DT.100885435 DT.120985324 DT.120985371 DT.95369312 DT.101977220 DT.91817422 DT.92448302 DT.100885442 DT.100885446 24/522 AceView cDNA sequences (see all 522): CD518057 AA133757 BQ639083 BM995172 AI859827 BM671293 AA679441 BQ009319 CR617677 AA447847 CR612194 BU663276 CA414762 BU739044 CR612144 AI161426 CR615384 AL543109 CB159724 AI858227 AA745603 AA447696 AW630390 AI865137
GeneLoc Exon Structure
5/11 Alternative Splicing Database (ASD) splice patterns (SP) for YPEL5 (see all 11) About this scheme
| ExUns: | 1a | · | 1b | · | 1c | · | 1d | ^ | 2a | · | 2b | ^ | 3a | · | 3b | · | 3c | ^ | 4a | · | 4b | ^ | 5a | · | 5b | ^ | 6a | · | 6b | · | 6c | · | 6d | · | 6e | · | 6f | · | 6g | · | 6h | · | 6i |
|---|
|
| SP1: | | | | | | | | | - | | - | | | | | | | | - | | | | - | | | | | | | | | | | | | | | | | | | | | | |
| SP2: | | | | | | | | | - | | - | | | | - | | - | | - | | - | | - | | | | | | | | | | | | | | | | | | | | | | |
| SP3: | | | | | | | | | - | | - | | - | | - | | - | | - | | | | - | | | | | | | | | | | | | | | | | | | | | | |
| SP4: | | | | | | | | | - | | - | | | | | | | | - | | - | | - | | | | | | | | | | | | | | | | | | | | | | |
| SP5: | | | | | | | | | - | | - | | | | | | - | | - | | - | | - | | | | | | | | | | | | | | | | | | | | | |
ECgene alternative splicing isoforms for YPEL5
|
Expression
for YPEL5 gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| YPEL5 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: TAACTTAAGC
About this image
See YPEL5 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for YPEL5
SOURCE GeneReport for Unigene cluster: Hs.515890
SABiosciences Custom PCR Arrays for YPEL5
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for YPEL5
Browse OriGene validated miRNA SYBR primer pairs
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse, rat YPEL5 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat YPEL5 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat YPEL5 | In Situ
Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for YPEL5 |
Orthologs
for YPEL5 gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of eukaryotes.
Orthologs for YPEL5 gene from 8/31 species (see all 31) About this table
ENSEMBL Gene Tree for YPEL5 (if available)
TreeFam Gene Tree for YPEL5 (if available) |
Paralogs
for YPEL5 gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| Paralogs for YPEL5 gene
- YPEL32 YPEL12 YPEL22 YPEL42
4 SIMAP similar genes for YPEL5 using alignment to 1 protein entry: YPEL5_HUMAN:YPEL4 YPEL3 YPEL1 YPEL2
YPEL5 for paralogs About GeneDecksing
4 Pseudogenes.org Pseudogenes for YPEL5
PGOHUM00000242664 PGOHUM00000239551 PGOHUM00000234526 PGOHUM00000244360
|
Genomic Variants
for YPEL5 gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 2 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for YPEL5 (30369750 - 30383399 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 4 variations for YPEL5
3 CNVs: 2374 3348 8366
1 Indel: 73141 | SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing YPEL5 |
|
Disorders
/ Diseases
for YPEL5 gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
YPEL5 for disorders About GeneDecksing
OMIM gene information: 609726
OMIM disorders: --
2  diseases for YPEL5: About MalaCardsbreast cancer malaria
Human Genome Epidemiology (HuGE) Navigator: YPEL5 (1 document)
Export disorders for YPEL5 gene to outside databases
|
Publications
for YPEL5 gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for YPEL5 gene, integrated from 9 sources (see all 13):
(articles sorted by number of sources associating them with YPEL5) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- Identification and characterization of a novel gene family YPEL in a wide spectrum of eukaryotic species. (PubMed id 15556292)1, 2, 9 Hosono K.... Shimizu N. (2004)
- Generation and annotation of the DNA sequences of human chromosomes 2 and 4. (PubMed id 15815621)1, 2 Hillier L.W....Wilson R.K. (2005)
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
- The Drosophila gene Yippee reveals a novel family of putative zinc binding proteins highly conserved among eukaryotes. (PubMed id 11240639)1, 2 Roxstroem-Lindquist K. and Faye I. (2001)
- Identification of novel human genes evolutionarily conserved in Caenorhabditis elegans by comparative proteomics. (PubMed id 10810093)1, 2 Lai C.H....Lin W. (2000)
- Systematic and quantitative assessment of the ubiquiti n-modified proteome. (PubMed id 21906983)1 Kim W....Gygi S.P. (2011)
- Initial characterization of the human central proteome. (PubMed id 21269460)2 Burkard T.R.... Colinge J. (2011)
- Mass spectrometric analysis of lysine ubiquitylation r eveals promiscuity at site level. (PubMed id 21139048)1 Danielsen J.M....Nielsen M.L. (2011)
- A proteome-wide, quantitative survey of in vivo ubiqui tylation sites reveals widespread regulatory roles. (PubMed id 21890473)1 Wagner S.A....Choudhary C. (2011)
- Centrosome-related genes, genetic variation, and risk of breast cancer. (PubMed id 20508983)1 Olson J.E....Couch F.J. (2010)
|
External Searches for YPEL5 gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
|
Genome Databases showing YPEL5 gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing YPEL5 gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing YPEL5 gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
| Name | Description |
| PharmGKB entry for YPEL5 | Pharmacogenomics, SNPs, Pathways |
|
| | |
About This Section
| Patent Information for YPEL5 gene:
Search GeneIP for patents involving YPEL5
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for YPEL5 gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript, LifeMap BioReagents, and Sirion Biotech, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences, In Situ Hybridization Assays from
Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory)
About This Section
|
 | |
 | |
 |
| | |  | Browse OriGene Antibodies | | OriGene shRNA RFP for YPEL5 | | | OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for YPEL5 | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for YPEL5 | | | OriGene Protein Over-expression Lysate for YPEL5 | | Browse OriGene Fluorogenic Cell Assay Kits | | | OriGene siRNA for YPEL5 | | OriGene 3'-UTR Clone for YPEL5 | | | OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for YPEL5 | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for YPEL5 | | | Browse OriGene GFP tagged cDNA clones in CMV expression vector | | Browse OriGene MicroRNA Expression Plasmids | | | Browse OriGene basic RS shRNAs | | Browse OriGene validated miRNA SYBR primer pairs | | | Browse OriGene full length recombinant human proteins expressed in human HEK293 cells | | OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
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| | | QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat YPEL5 | | | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing YPEL5 | | | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat YPEL5 | | | QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat YPEL5 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat YPEL5 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat YPEL5 |
| |
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| |  |  |  |  | | | | |
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 | | | YPEL5 Proteins, Antibodies, CLIAs, and ELISAs |
| | | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for YPEL5 |
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