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YPEL5 Gene

protein-coding   GIFtS: 46

GC02P030223
yippee-like 5 (Drosophila)
Symbol approved by the HUGO Gene Nomenclature Committee (HGNC) database
Services    
(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc , and/or 7Ensembl, 8miRBase)
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Aliases
CGI-127 1, 2
OTTHUMP00000123521 2
OTTHUMP00000123522 2
Descriptions
yippee protein 2
yippee-like 5 2
yippee-like 5 (Drosophila) 2
External Ids
HGNC: 183291
Entrez Gene: 516462
UniProtKB: P626993
Ensembl: ENSG000001198017
Search outside databases for aliases for YPEL5 gene

Previous GC identifers: GC02P030345 GC02P030281

(According to Entrez Gene, Wikipedia's Gene Wiki,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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  --
(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 36),
and/or miRBase,
Genomic Views according to UCSC and Ensembl, Transcription factor binding sites according to SABiosciences)
About This Section

Genomic View:
UCSC Golden Path with GeneCards custom track

 Transcription factor binding sites upstream to the YPEL5 gene  

Entrez Gene cytogenetic band: 2p23.1   Ensembl cytogenetic band:  2p23.1   HGNC cytogenetic band: 2p23

YPEL5 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)

GeneLoc gene densities for chromosome 2         GeneLoc Exon Structure

GeneLoc location for GC02P030223:     (about GC identifiers)

Start:
30,223,311 bp from pter
End:
30,236,903 bp from pter
Size:
13,593 bases
Orientation:
plus strand
RefSeq DNA sequence:
NC_000002.10  NT_022184.14  
(According to 1UniProtKB, and/or Ensembl, Phosphorylation sites according to 2Phosphosite, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Enzo Life Sciences, Abnova, OriGene and/or, Abcam,
Biochemical Assays by Invitrogen, Millipore, R&D Systems, Cell Signaling Technology, and/or Enzo Life Sciences, Ontologies according to Gene Ontology Consortium 01 Apr 2009 and Entrez Gene, Antibodies by Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Cell Signaling Technology, Abcam, Abnova, and/or Novus Biologicals)
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UniProtKB/Swiss-Prot: YPEL5_HUMAN, P62699 (See protein sequence)
Recommended Name: Protein yippee-like 5  
Size: 121 amino acids; 13842 Da
Secondary accessions: Q65Z97 Q8R174 Q9D6M1 Q9UMX7 Q9Y3C9

Post-translational modifications:

  • View phosphorylation sites using PhosphoSite2


  • REFSEQ proteins (4 alternative transcripts): 
    NP_001120871.1  NP_001120872.1  NP_001120873.1  NP_057145.1  


    ENSEMBL proteins: 
    ENSP00000261353 ENSP00000385278 ENSP00000368834 ENSP00000383974 ENSP00000384140 ENSP00000368835 


    Human Recombinant Proteins 
    Browse Drug Discovery Central at Invitrogen for human recombinant proteins
    Browse Purified and Recombinant Proteins at Millipore
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    Browse R&D Systems for human recombinant proteins
    Browse recombinant and purified proteins available from Enzo Life Sciences
    Browse Abcam for Recombinant Proteins
    Browse Abnova for Human Recombinant Proteins
                  OriGene Purified Recombinant Human Protein: YPEL5 


    Antibodies for YPEL5: 
    Browse Antibodies Central at Invitrogen
    Browse Millipore's Extensive Line of Mono- and Polyclonal Antibodies
    Browse Antibodies at Sigma-Aldrich
    Browse R&D Systems for Antibodies
    Search for antibodies at Abcam and the World's Antibody Gateway (free search engine of over 150 antibody companies)
    Browse Abnova for Monoclonal and Polyclonal Antibodies
    Search Novus for antibodies for YPEL5

    Assays for YPEL5: 
    Browse Invitrogen for biochemical assays
    Browse Kits and Assays available from Millipore
    Browse R&D Systems for biochemical assays
    Browse biochemical assays available from Enzo Life Sciences

    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section

    1 InterPro domain/family:
     IPR004910 Yippee


       GeneDecks  YPEL5 for the domains selected above  
    About GeneDecksing

    Graphical View of Domain Structure for InterPro Entry P62699

    ProtoNet protein and cluster: P62699

    1 Blocks protein family: IPB004910 Yippee-like protein

    UniProtKB/Swiss-Prot: YPEL5_HUMAN, P62699
    Similarity: Belongs to the yippee family

    (According to MGI Jun 06 2009, UniProtKB, IUBMB,and/or Genatlas,
    shRNA from OriGene, Sigma-Aldrich, RNAi from Sigma-Aldrich,
    RNAi Products, Clones, and Q-PCR Products from Invitrogen, Millipore, OriGene, and/or Abnova, siRNAs from Applied Biosystems, SYBR primers from OriGene, Cell-based Assays from Millipore, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
    About This Section

    Inhib.
    RNA:
    Invitrogen RNAi Products for gene knock-down (YPEL5)
    Browse for Gene Knock-down Tools from Millipore
    Browse Abnova for Chimera RNAi Products
                   OriGene 29mer shRNA kit in GFP-retroviral vectors (see all 4): NM_016061

                  Applied Biosystems Silencer® siRNAs for YPEL5

                  Sigma-Aldrich siRNA for YPEL5  
                         Sigma-Aldrich shRNA for YPEL5  
                         Explore Sigma-Aldrich super-pooled esiRNAs  

    Clones:Browse Clone Ranger at Invitrogen for clones
    Browse Clones for the Expression of Recombinant Proteins Available from Millipore
                   OriGene GFP tagged cDNA clones in CMV expression vector (see all 4): NM_001127399
                                     Myc/DDK tagged cDNA clones in CMV expression vector (see all 4): NM_001127399
                                     untagged cDNA clones in CMV expression vector (see all 4): NM_001127399 

    Primers: Browse Quantitative PCR Central at Invitrogen for Q-PCR LUX™ Primers
                  OriGene genome-wide validated SYBR primer pairs: NM_001127401

    (Pathways according to Invitrogen (maps by GeneGo), Millipore, Cell Signaling Technology, Sigma-Aldrich, KEGG and/or UniProtKB,
    Sets of similar genes according to GeneDecks, Proteins Network according to SABiosciences, Interactions according to 1UniProtKB, 2MINT, and/or 3STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
    About This Section


      --
    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, Sigma-Aldrich, Tocris Bioscience, and/or Novoseek and Drugs according to Enzo Life Sciences and/or PharmGKB)
    About This Section

    Browse drugs & compounds from Enzo Life Sciences
    Browse Small Molecules at Sigma-Aldrich

    Browse Tocris compounds for YPEL5

    (GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 219 Homo sapiens; Jun 2 2009) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView,
    non coding RNAs according to RNAdb,
    ESTs according to GeneTide,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from Invitrogen, Millipore, and/or Abnova,
    siRNAs from Applied Biosystems, Sigma-Aldrich,
    shRNA from Sigma-Aldrich, OriGene,
    Tagged/untagged cDNA clones from OriGene,
    Expression Assays from Applied Biosystems)
    About This Section

    Inhib.
    RNA:
    Invitrogen RNAi Products for gene knock-down (YPEL5)
    Browse for Gene Knock-down Tools from Millipore
    Browse Abnova for Chimera RNAi Products
                   OriGene 29mer shRNA kit in GFP-retroviral vectors (see all 4): NM_016061

                  Sigma-Aldrich siRNA for YPEL5  
                         Sigma-Aldrich shRNA for YPEL5  
                         Explore Sigma-Aldrich super-pooled esiRNAs  

    Applied Biosystems Silencer® siRNAs: 

    NM_001127399  NM_001127400  NM_001127401  NM_016061  

    REFSEQ mRNAs for YPEL5 gene (4 alternative transcripts): 

    NM_001127399.1   NM_001127400.1   NM_001127401.1   NM_016061.2   

    Applied Biosystems TaqMan ® Gene Expression Assays: 

    NM_001127399  NM_001127400  NM_001127401  NM_016061  

                   OriGene GFP tagged cDNA clones in CMV expression vector (see all 4): NM_001127399
                                     Myc/DDK tagged cDNA clones in CMV expression vector (see all 4): NM_001127399
                                     untagged cDNA clones in CMV expression vector (see all 4): NM_001127399 

    Additional cDNA sequence: 

    AB098739.1 AF135161.1 AF151885.1 AF172940.1 AK025730.1 AK307099.1 AK311404.1 BC000836.1 
    BC047237.1 CR590716.1 CR612144.1 CR612194.1 CR615384.1 CR617186.1 CR617677.1 CR620890.1 
    CR622707.1 CR623255.1 

    24 DOTS entries:

    DT.319786  DT.100885434  DT.92448299  DT.100885436  DT.97767180  DT.92448297  DT.91664542  DT.92448301 
    DT.92448298  DT.120985340  DT.92448305  DT.95227142  DT.95369308  DT.120985374  DT.100885435  DT.120985324 
    DT.100885442  DT.120985371  DT.95369312  DT.101977220  DT.91817422  DT.92448302  DT.100885446  DT.91934924 

    24/522 AceView cDNA sequences (see all 522 ):

    BM850701 BM856482 AA883267 BE675523 AA447847 AV682350 CR615384 BM664463 
    AI149536 AI458367 AA745603 CR617186 H24217 CR612144 AA152318 AV714538 
    AA621431 AI367687 BF589710 AI150177 AA682763 CR622707 AW074691 AA364531 

    highest scoring ESTs for YPEL5:

    AA151651 AA027857 AA033645 AA055324 AA083837 AA115539 AA133758 AA152318 AA152423 AA165032 

    Unigene Cluster for YPEL5:

    Yippee-like 5 (Drosophila)
    Hs.515890  [show with all ESTs]
    Unigene Representative Sequence: NM_001127401


    GeneLoc Exon Structure

    5/11 Alternative Splicing Database (ASD) splice patterns (SP) for YPEL5 (see all 11 )

    ExUns: 1a · 1b · 1c · 1d ^ 2a · 2b ^ 3a · 3b · 3c ^ 4a · 4b ^ 5a · 5b ^ 6a · 6b · 6c · 6d · 6e · 6f · 6g · 6h · 6i
    SP1:                          -     -                       -           -                                                               
    SP2:                          -     -           -     -     -     -     -                                                               
    SP3:                          -     -     -     -     -     -           -                                                               
    SP4:                          -     -                       -     -     -                                                               
    SP5:                          -     -                 -     -     -     -                                                               

    About this scheme

    ECgene alternative splicing isoforms for YPEL5

    6 Ensembl transcripts including schematic representations:
    ENST00000261353  ENST00000402708  ENST00000379519  ENST00000402003  ENST00000408026  ENST00000379520  
    (Experimental results according to 1GeneNote and GNF BioGPS,
    probe sets-to-genes annotations according to 2GeneAnnot , 3GeneTide , Sets of similar genes according to GeneDecks, Electronic Northern calculations according to data from UniGene (Build 219 Homo sapiens), SAGE tags according to CGAP, plus additional links to SOURCE, and/or GNF BioGPS, and/or EXPOLDB, and/or UniProtKB,
    Expression Assays from Applied Biosystems )
    About This Section

    YPEL5 expression in normal and diseased human tissues

     Applied Biosystems TaqMan ® Gene Expression Assays for YPEL5

    1 / 2 / 3

    5 probe-sets matching YPEL5 gene


    Affymetrix
    probe-set
    Array  GeneAnnot data GeneNote data GeneTide data
    # genes Sensitivity Specificity Correlation Length Gb_Accession Consensus Uniqueness Score Rank

    45270_at2, 3 U95-B 1 1.00 1.00 1.00 1.00 AA151651 1.00 1.00 1.00 1

    222408_s_at2, 3 U133-B 1 1.00 1.00 -- -- BC000836 0.80 1.00 0.91 1

    217783_s_at2, 3 U133-A 1 1.00 1.00 -- -- NM_016061 0.60 1.00 0.82 1

    222408_s_at2 U133Plus2 1 1.00 1.00 -- -- -- -- -- -- --

    217783_s_at2 U133Plus2 1 1.00 1.00 -- -- -- -- -- -- --
    About this table
    Data from (Publications) and GNF BioGPS
        About these images
    About these images

    CGAP SAGE TAG: TAACTTAAGC

    SOURCE GeneReport for Unigene cluster: Hs.515890
    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD and/or 5MGI Jun 06 2009, with possible further links to Flybase and/or WormBase, Gene Trees according to Ensembl)
    About This Section


    Orthologs for YPEL5 gene from 5/13 species (see all 13 )
    Organism Gene Locus Description Human
    Similarity
    NCBI accessions
    dog
    (Canis familiaris)
    YPEL51   -- yippee-like 5 (Drosophila) 95.87(n)
    100(a)
    475714  XM_857398.1  XP_862491.1 
    chimpanzee
    (Pan troglodytes)
    YPEL51   -- yippee-like 5 (Drosophila) 99.72(n)
    100(a)
    459128  XM_515383.2  XP_515383.2 
    cow
    (Bos taurus)
    YPEL51   -- yippee-like 5 (Drosophila) 96.42(n)
    100(a)
    780856  XM_001249349.1  XP_001249350.1 
    rat
    (Rattus norvegicus)
    Ypel51   -- yippee-like 5 (Drosophila) 96.14(n)
    100(a)
    298792  NM_001035221.1  NP_001030298.1 
    mouse
    (Mus musculus)
    Ypel51, 5 175
    yippee-like 5 (Drosophila)1, 5 95.59(n)1
    100(a)1
    3832951  NM_027166.41  NP_081442.11 
     AA5912955  AB0987445  (see all 21)
    About this table        Species with no ortholog for YPEL5

    ENSEMBL Gene Tree for YPEL5
    (Paralogs according to 1HomoloGene
    and 2Ensembl, Pseudogenes according to 3Pseudogene.org)
    About This Section

    Paralogs for YPEL5 gene
    YPEL12  YPEL32  YPEL22  YPEL42  

    (According to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, and UniProtKB, Linkage Disequilibrium by HapMap, Genotyping Reagents from Applied Biosystems)
    About This Section


    10/69 NCBI SNPs in YPEL5 are shown (see all 69 )
    (Click for Applied Biosystems TaqMan ® Genotyping Assay)  (see all 32)
    ABGenomic DataTranscription DataAllele Frequencies
    SNP IDValidChr 2 posSequenceRecsAA
    Chg
    TypeMoreRecsAllele
    freq
    PopTotal
    sample
    More
    ------------
    rs49519831,2
    A,C,F,H30235405(+) AGCAGT/CGTGTA 4 -- ut31 ese32Minor allele frequency- C:0.07EU WA 238
    --
    rs30878951,2
    A,C,F,H30235457(-) CAAGAT/CGTAAA 4 -- ut31 ese33Minor allele frequency- C:0.11MN EU WA 424
    rs22765481,2
    A,C,F30223164(+) AGGGTG/AAGCCA 1 -- ng511Minor allele frequency- A:0.13EA 1492
    rs37545351,2
    C,F,H30222380(+) CCGAAA/CGTCAG 1 -- ng517Minor allele frequency- C:0.19EA MN EU WA 2078
    rs170091761,2
    F,H30236556(+) CATGCT/CCAATT 4 -- ut317Minor allele frequency- C:0.01NA EU EA WA 516
    --
    rs65479951,2
    A,C30221346(+) cgggcA/Gtggtg 1 -- ng510--------
    rs37686711,2
    F,H30236117(+) TGTCAA/GTGTGC 4 -- ut314Minor allele frequency- G:0.34EU EA WA 418
    --
    rs75887771,2
    A,C30224862(+) AGTGCC/TTTGGT 3 -- int1 ut510--------
    rs124705121,2
    C30223212(+) GAGGAA/CAGGGG 1 -- ng510--------
    rs11372881,2
    C,F,H30235009(+) TACAGC/TGAAGT 4 S/S syn114Minor allele frequency- T:0.35EA MN NA EU WA 2656
    About this table

    HapMap Linkage Disequilibrium images for YPEL5 (up to first 250kb)

    (in which this Gene is Involved, According to OMIM, UniProtKB, PharmGKB, Genatlas, GeneTests, Blood group antigen gene mutations by BGMUT, HGMD, GAD, HuGE Navigator, BCGD, and/or TGDB.)
    About This Section

    OMIM: 609726

    (Possibly Related Articles in Doctor's Guide)
    About This Section

      --

    (in PubMed. Associations of this gene to articles via 1Novoseek, 2HGNC, 3Entrez Gene, 4UniProtKB/Swiss-Prot, 5UniProtKB/TrEMBL, 6GAD, and/or 7PharmGKB)
    About This Section

    6 PubMed articles for YPEL5 gene:
    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section

     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)
    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, and/or H-InvDB)
    About This Section

    Entrez Gene: 51646 HGNC: 18329 AceView: YPEL5 Ensembl:ENSG00000119801 euGenes: HUgn51646
    ECgene: YPEL5 H-InvDB: YPEL5
    (According to HUGE)
    About This Section

      --
    (According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section

      --
    (Available from WIS Yeda, Salk, Tufts)
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      --
    (Reagents available from Applied Biosystems, Antibodies and assays by Cell Signaling Technology, Abcam, Novus Biologicals,
    Sigma-Aldrich, R&D Systems, Millipore, Abnova, and/or Invitrogen, Clones available from OriGene,and/or Invitrogen, Drugs and/or compounds by Sigma-Aldrich,
    Enzo Life Sciences, and/or Tocris Bioscience)
    About This Section



    Products for YPEL5:
     TaqMan ® Gene Expression Assays
     TaqMan ® Genotyping Assays
      Free SNP selection tool



      Invitrogen iPath Pathways  Invitrogen BLOCK-iT™ RNAi
      Invitrogen Antibodies  Invitrogen Assays
      Invitrogen Clones  Invitrogen Q-PCR Products
      Invitrogen Human Recombinant Kinases  Invitrogen Custom Antibody and Peptide Service
      Invitrogen Proteins / Assays / Screening Services  Search Invitrogen catalog for YPEL5-related products

     Millipore Custom Antibody & Bulk Services
     Millipore Preclinical / Clinical Development Services
     Millipore Immunoassay Services
     Millipore Target Screening & Profiling Services


     Predesigned and custom siRNAs for YPEL5 Browse antibodies at Sigma-Aldrich
     Explore super-pooled esiRNAs Browse proteins at Sigma-Aldrich
     Lentivirus-delivered shRNAs for YPEL5 Browse small molecules at Sigma-Aldrich
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     Search Tocris compounds for YPEL5




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     Search Novus for antibodies for YPEL5

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