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Aliases for YPEL5 Gene

Aliases for YPEL5 Gene

  • Yippee Like 5 2 3 5
  • Yippee-Like 5 (Drosophila) 2
  • Protein Yippee-Like 5 3
  • CGI-127 3

External Ids for YPEL5 Gene

Previous GeneCards Identifiers for YPEL5 Gene

  • GC02P030345
  • GC02P030281
  • GC02P030223
  • GC02P030369

Summaries for YPEL5 Gene

GeneCards Summary for YPEL5 Gene

YPEL5 (Yippee Like 5) is a Protein Coding gene. Among its related pathways are Immune System. An important paralog of this gene is YPEL1.

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for YPEL5 Gene

Genomics for YPEL5 Gene

Regulatory Elements for YPEL5 Gene

Enhancers for YPEL5 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH02F030113 0.5 Ensembl ENCODE 17.1 -32.3 -32284 2.7 ELF3 HDGF PKNOX1 SIN3A ZBTB40 RAD21 ZNF366 SCRT2 ZNF143 ZNF207 YPEL5 LOC101929418 ENSG00000225943
GH02F030264 1.1 FANTOM5 Ensembl ENCODE 9.8 +119.7 119708 4.8 CHAMP1 ZFHX2 ZNF316 NCOR1 FOS MAFK EGR2 HLF NR2F1 MAFG ENSG00000207187 LBH YPEL5 GC02P030258 LOC102723594
GH02F030145 1.1 FANTOM5 ENCODE 8.2 +1.1 1062 5.7 HDGF PKNOX1 CREB3L1 ARID4B SIN3A ZNF2 YY1 SLC30A9 ZNF143 ZNF207 YPEL5 LBH PIR52638
GH02F030332 0.8 FANTOM5 Ensembl ENCODE 7.3 +189.3 189303 7.6 HDGF PKNOX1 TBL1XR1 RAD21 ZBTB40 EGR1 ZNF143 ETV6 RCOR1 CREM ENSG00000207187 YPEL5 LBH LINC01936 LOC102723594
GH02F030221 1.4 FANTOM5 Ensembl ENCODE 6 +77.7 77727 6.4 HDGF CREB3L1 ZFP64 ARID4B SIN3A DMAP1 YY1 ZNF143 ZNF207 KLF13 YPEL5 LBH ENSG00000231712
- Elite enhancer/Elite enhancer-gene association Download Table
Download GeneHancer data dump

Enhancers around YPEL5 on UCSC Golden Path with GeneCards custom track

Promoters for YPEL5 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000587491 416 2601 HDGF PKNOX1 CREB3L1 ARID4B SIN3A ZNF2 YY1 SLC30A9 ZNF143 ZNF207

Genomic Location for YPEL5 Gene

30,146,884 bp from pter
30,160,533 bp from pter
13,650 bases
Plus strand

Genomic View for YPEL5 Gene

Genes around YPEL5 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
YPEL5 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for YPEL5 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for YPEL5 Gene

Proteins for YPEL5 Gene

  • Protein details for YPEL5 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Protein yippee-like 5
    Protein Accession:
    Secondary Accessions:
    • D6W568
    • Q65Z97
    • Q8R174
    • Q9D6M1
    • Q9UMX7
    • Q9Y3C9

    Protein attributes for YPEL5 Gene

    121 amino acids
    Molecular mass:
    13842 Da
    Quaternary structure:
    No Data Available

neXtProt entry for YPEL5 Gene

Post-translational modifications for YPEL5 Gene

  • Ubiquitination at Lys 47
  • Modification sites at PhosphoSitePlus

No data available for DME Specific Peptides for YPEL5 Gene

Domains & Families for YPEL5 Gene

Gene Families for YPEL5 Gene

Protein Domains for YPEL5 Gene

Suggested Antigen Peptide Sequences for YPEL5 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Contains 1 Yippee domain.
  • Belongs to the yippee family.
  • Contains 1 Yippee domain.
  • Belongs to the yippee family.
genes like me logo Genes that share domains with YPEL5: view

Function for YPEL5 Gene

Gene Ontology (GO) - Molecular Function for YPEL5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0046872 metal ion binding IEA --
genes like me logo Genes that share ontologies with YPEL5: view
genes like me logo Genes that share phenotypes with YPEL5: view

Animal Model Products

miRNA for YPEL5 Gene

miRTarBase miRNAs that target YPEL5

Inhibitory RNA Products

Flow Cytometry Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for YPEL5 Gene

Localization for YPEL5 Gene

Subcellular locations from

Jensen Localization Image for YPEL5 Gene COMPARTMENTS Subcellular localization image for YPEL5 gene
Compartment Confidence
cytosol 3
nucleus 3
extracellular 1
mitochondrion 1
peroxisome 1

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Gene Ontology (GO) - Cellular Components for YPEL5 Gene

Pathways & Interactions for YPEL5 Gene

SuperPathways for YPEL5 Gene

SuperPathway Contained pathways
1 Immune System
genes like me logo Genes that share pathways with YPEL5: view

Pathways by source for YPEL5 Gene

2 Reactome pathways for YPEL5 Gene

Gene Ontology (GO) - Biological Process for YPEL5 Gene


No data available for SIGNOR curated interactions for YPEL5 Gene

Transcripts for YPEL5 Gene

Unigene Clusters for YPEL5 Gene

Yippee-like 5 (Drosophila):
Representative Sequences:

Inhibitory RNA Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for YPEL5 Gene

ExUns: 1a · 1b · 1c · 1d ^ 2a · 2b ^ 3a · 3b · 3c ^ 4a · 4b ^ 5a · 5b ^ 6a · 6b · 6c · 6d · 6e · 6f · 6g · 6h · 6i
SP1: - - - -
SP2: - - - - - - -
SP3: - - - - - - -
SP4: - - - - -
SP5: - - - - - -
SP6: - - - - -
SP7: - - - - - - - -
SP8: - -
SP9: - - - - - -
SP10: -

Relevant External Links for YPEL5 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for YPEL5 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for YPEL5 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for YPEL5 Gene

This gene is overexpressed in Hair follicle (36.6) and Peripheral blood mononuclear cells (9.5).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for YPEL5 Gene

Protein tissue co-expression partners for YPEL5 Gene

NURSA nuclear receptor signaling pathways regulating expression of YPEL5 Gene:


SOURCE GeneReport for Unigene cluster for YPEL5 Gene:

genes like me logo Genes that share expression patterns with YPEL5: view

Primer Products

No data available for mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for YPEL5 Gene

Orthologs for YPEL5 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for YPEL5 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia YPEL5 34 35
  • 100 (n)
(Monodelphis domestica)
Mammalia YPEL5 35
  • 100 (a)
(Ornithorhynchus anatinus)
Mammalia YPEL5 35
  • 100 (a)
(Bos Taurus)
Mammalia YPEL5 34 35
  • 96.69 (n)
(Rattus norvegicus)
Mammalia Ypel5 34
  • 96.42 (n)
(Canis familiaris)
Mammalia YPEL5 34 35
  • 96.14 (n)
(Mus musculus)
Mammalia Ypel5 34 16 35
  • 95.87 (n)
(Gallus gallus)
Aves YPEL5 34 35
  • 86.5 (n)
(Anolis carolinensis)
Reptilia YPEL5 35
  • 100 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia ypel5 34
  • 81.82 (n)
Str.5006 34
African clawed frog
(Xenopus laevis)
Amphibia Xl.26158 34
(Danio rerio)
Actinopterygii ypel5 35
  • 93 (a)
LOC100332089 34
  • 79.89 (n)
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.10271 34
fruit fly
(Drosophila melanogaster)
Insecta Yippee 34 35
  • 66.95 (n)
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP000780 34
  • 64.62 (n)
(Caenorhabditis elegans)
Secernentea B0546.3 35
  • 14 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes MOH1 35
  • 30 (a)
thale cress
(Arabidopsis thaliana)
eudicotyledons AT2G40110 34
  • 48.18 (n)
(Oryza sativa)
Liliopsida Os03g0698500 34
  • 50.56 (n)
sea squirt
(Ciona savignyi)
Ascidiacea CSA.3746 35
  • 74 (a)
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.1753 34
Species where no ortholog for YPEL5 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for YPEL5 Gene

Gene Tree for YPEL5 (if available)
Gene Tree for YPEL5 (if available)

Paralogs for YPEL5 Gene

Paralogs for YPEL5 Gene

(4) SIMAP similar genes for YPEL5 Gene using alignment to 1 proteins: Pseudogenes for YPEL5 Gene

genes like me logo Genes that share paralogs with YPEL5: view

Variants for YPEL5 Gene

Sequence variations from dbSNP and Humsavar for YPEL5 Gene

SNP ID Clin Chr 02 pos Sequence Context AA Info Type
rs1060243 -- 30,159,442(+) TTGTC(A/C)CCACA utr-variant-3-prime
rs1060255 -- 30,159,474(+) TTTTT(C/T)TGAGA utr-variant-3-prime
rs1060300 -- 30,160,404(+) TCAAT(C/T)TGAGA utr-variant-3-prime
rs10657601 -- 30,152,883(+) GACTG(-/TCC)TCCTT intron-variant
rs10711338 -- 30,160,864(+) TTTGC(-/A)AAAAA downstream-variant-500B

Structural Variations from Database of Genomic Variants (DGV) for YPEL5 Gene

Variant ID Type Subtype PubMed ID
dgv6747n54 CNV gain 21841781
esv2759035 CNV gain 17122850
esv29927 CNV loss 19812545
esv34904 CNV gain 17911159
nsv581259 CNV gain+loss 21841781
nsv953763 CNV duplication 24416366

Variation tolerance for YPEL5 Gene

Residual Variation Intolerance Score: 47.2% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.07; 1.49% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for YPEL5 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for YPEL5 Gene

Disorders for YPEL5 Gene

Relevant External Links for YPEL5

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator
Atlas of Genetics and Cytogenetics in Oncology and Haematology:

No disorders were found for YPEL5 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for YPEL5 Gene

Publications for YPEL5 Gene

  1. Identification and characterization of a novel gene family YPEL in a wide spectrum of eukaryotic species. (PMID: 15556292) Hosono K. … Shimizu N. (Gene 2004) 2 3 4 22 64
  2. Centrosome-related genes, genetic variation, and risk of breast cancer. (PMID: 20508983) Olson J.E. … Couch F.J. (Breast Cancer Res. Treat. 2011) 3 46 64
  3. Generation and annotation of the DNA sequences of human chromosomes 2 and 4. (PMID: 15815621) Hillier L.W. … Wilson R.K. (Nature 2005) 3 4 64
  4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4 64
  5. The Drosophila gene Yippee reveals a novel family of putative zinc binding proteins highly conserved among eukaryotes. (PMID: 11240639) Roxstroem-Lindquist K. … Faye I. (Insect Mol. Biol. 2001) 3 4 64

Products for YPEL5 Gene

Sources for YPEL5 Gene

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