Free for academic non-profit institutions. Other users need a Commercial license

Aliases for YPEL5 Gene

Aliases for YPEL5 Gene

  • Yippee Like 5 2 3 5
  • Yippee-Like 5 (Drosophila) 2
  • Yippee-Like 5 3
  • CGI-127 3

External Ids for YPEL5 Gene

Previous GeneCards Identifiers for YPEL5 Gene

  • GC02P030345
  • GC02P030281
  • GC02P030223
  • GC02P030369

Summaries for YPEL5 Gene

GeneCards Summary for YPEL5 Gene

YPEL5 (Yippee Like 5) is a Protein Coding gene. An important paralog of this gene is YPEL2.

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for YPEL5 Gene

Genomics for YPEL5 Gene

Regulatory Elements for YPEL5 Gene

Promoters for YPEL5 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around YPEL5 on UCSC Golden Path with GeneCards custom track

Genomic Location for YPEL5 Gene

Chromosome:
2
Start:
30,146,884 bp from pter
End:
30,160,533 bp from pter
Size:
13,650 bases
Orientation:
Plus strand

Genomic View for YPEL5 Gene

Genes around YPEL5 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
YPEL5 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for YPEL5 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for YPEL5 Gene

Proteins for YPEL5 Gene

  • Protein details for YPEL5 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P62699-YPEL5_HUMAN
    Recommended name:
    Protein yippee-like 5
    Protein Accession:
    P62699
    Secondary Accessions:
    • D6W568
    • Q65Z97
    • Q8R174
    • Q9D6M1
    • Q9UMX7
    • Q9Y3C9

    Protein attributes for YPEL5 Gene

    Size:
    121 amino acids
    Molecular mass:
    13842 Da
    Quaternary structure:
    No Data Available

neXtProt entry for YPEL5 Gene

Proteomics data for YPEL5 Gene at MOPED

Post-translational modifications for YPEL5 Gene

  • Ubiquitination at Lys 47
  • Modification sites at PhosphoSitePlus

Antibody Products

No data available for DME Specific Peptides for YPEL5 Gene

Domains & Families for YPEL5 Gene

Gene Families for YPEL5 Gene

Protein Domains for YPEL5 Gene

InterPro:
Blocks:
ProtoNet:

Suggested Antigen Peptide Sequences for YPEL5 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

P62699

UniProtKB/Swiss-Prot:

YPEL5_HUMAN :
  • Contains 1 Yippee domain.
  • Belongs to the yippee family.
Domain:
  • Contains 1 Yippee domain.
Family:
  • Belongs to the yippee family.
genes like me logo Genes that share domains with YPEL5: view

Function for YPEL5 Gene

genes like me logo Genes that share phenotypes with YPEL5: view

Animal Model Products

miRNA for YPEL5 Gene

miRTarBase miRNAs that target YPEL5

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for YPEL5 Gene

Localization for YPEL5 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for YPEL5 Gene COMPARTMENTS Subcellular localization image for YPEL5 gene
Compartment Confidence
cytosol 3
nucleus 3
extracellular 1
mitochondrion 1
peroxisome 1

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Gene Ontology (GO) - Cellular Components for YPEL5 Gene

Pathways & Interactions for YPEL5 Gene

SuperPathways for YPEL5 Gene

No Data Available

Interacting Proteins for YPEL5 Gene

Gene Ontology (GO) - Biological Process for YPEL5 Gene

None

No data available for Pathways by source and SIGNOR curated interactions for YPEL5 Gene

Drugs & Compounds for YPEL5 Gene

No Compound Related Data Available

Transcripts for YPEL5 Gene

Unigene Clusters for YPEL5 Gene

Yippee-like 5 (Drosophila):
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for YPEL5 Gene

ExUns: 1a · 1b · 1c · 1d ^ 2a · 2b ^ 3a · 3b · 3c ^ 4a · 4b ^ 5a · 5b ^ 6a · 6b · 6c · 6d · 6e · 6f · 6g · 6h · 6i
SP1: - - - -
SP2: - - - - - - -
SP3: - - - - - - -
SP4: - - - - -
SP5: - - - - - -
SP6: - - - - -
SP7: - - - - - - - -
SP8: - -
SP9: - - - - - -
SP10: -
SP11:

Relevant External Links for YPEL5 Gene

GeneLoc Exon Structure for
YPEL5
ECgene alternative splicing isoforms for
YPEL5

Expression for YPEL5 Gene

mRNA expression in normal human tissues for YPEL5 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for YPEL5 Gene

This gene is overexpressed in Hair follicle (36.6) and Peripheral blood mononuclear cells (9.5).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for YPEL5 Gene



SOURCE GeneReport for Unigene cluster for YPEL5 Gene Hs.515890

genes like me logo Genes that share expression patterns with YPEL5: view

Protein tissue co-expression partners for YPEL5 Gene

Primer Products

In Situ Assay Products

No data available for mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for YPEL5 Gene

Orthologs for YPEL5 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for YPEL5 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia YPEL5 35
  • 96.69 (n)
  • 100 (a)
YPEL5 36
  • 100 (a)
OneToOne
dog
(Canis familiaris)
Mammalia YPEL5 35
  • 96.14 (n)
  • 100 (a)
YPEL5 36
  • 100 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Ypel5 35
  • 95.87 (n)
  • 100 (a)
Ypel5 16
Ypel5 36
  • 100 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia YPEL5 35
  • 100 (n)
  • 100 (a)
YPEL5 36
  • 100 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Ypel5 35
  • 96.42 (n)
  • 100 (a)
oppossum
(Monodelphis domestica)
Mammalia YPEL5 36
  • 100 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia YPEL5 36
  • 100 (a)
OneToOne
chicken
(Gallus gallus)
Aves YPEL5 35
  • 86.5 (n)
  • 100 (a)
YPEL5 36
  • 100 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia YPEL5 36
  • 100 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia Str.5006 35
ypel5 35
  • 81.82 (n)
  • 100 (a)
African clawed frog
(Xenopus laevis)
Amphibia Xl.26158 35
zebrafish
(Danio rerio)
Actinopterygii LOC100332089 35
  • 79.89 (n)
  • 99.17 (a)
ypel5 36
  • 93 (a)
OneToOne
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.10271 35
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP000780 35
  • 64.62 (n)
  • 72.81 (a)
fruit fly
(Drosophila melanogaster)
Insecta Yippee 35
  • 66.95 (n)
  • 74.36 (a)
Yippee 36
  • 70 (a)
OneToOne
worm
(Caenorhabditis elegans)
Secernentea B0546.3 36
  • 14 (a)
OneToOne
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes MOH1 36
  • 30 (a)
OneToMany
thale cress
(Arabidopsis thaliana)
eudicotyledons AT2G40110 35
  • 48.18 (n)
  • 42.73 (a)
rice
(Oryza sativa)
Liliopsida Os03g0698500 35
  • 50.56 (n)
  • 47.46 (a)
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.1753 35
sea squirt
(Ciona savignyi)
Ascidiacea CSA.3746 36
  • 74 (a)
OneToOne
Species with no ortholog for YPEL5:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for YPEL5 Gene

ENSEMBL:
Gene Tree for YPEL5 (if available)
TreeFam:
Gene Tree for YPEL5 (if available)

Paralogs for YPEL5 Gene

Paralogs for YPEL5 Gene

(4) SIMAP similar genes for YPEL5 Gene using alignment to 1 proteins:

Pseudogenes.org Pseudogenes for YPEL5 Gene

genes like me logo Genes that share paralogs with YPEL5: view

Variants for YPEL5 Gene

Sequence variations from dbSNP and Humsavar for YPEL5 Gene

SNP ID Clin Chr 02 pos Sequence Context AA Info Type
rs1060243 -- 30,159,442(+) TTGTC(A/C)CCACA utr-variant-3-prime
rs1060255 -- 30,159,474(+) TTTTT(C/T)TGAGA utr-variant-3-prime
rs1060300 -- 30,160,404(+) TCAAT(C/T)TGAGA utr-variant-3-prime
rs1137288 -- 30,158,639(+) TACAG(C/T)GAAGT reference, synonymous-codon
rs1345151 -- 30,152,320(-) CATAC(A/G)TACCA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for YPEL5 Gene

Variant ID Type Subtype PubMed ID
dgv1163e1 CNV Complex 17122850
esv34904 CNV Gain 17911159
esv29927 CNV Loss 19812545

Variation tolerance for YPEL5 Gene

Residual Variation Intolerance Score: 47.2% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.07; 1.49% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for YPEL5 Gene

HapMap Linkage Disequilibrium report
YPEL5

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for YPEL5 Gene

Disorders for YPEL5 Gene

Relevant External Links for YPEL5

Genetic Association Database (GAD)
YPEL5
Human Genome Epidemiology (HuGE) Navigator
YPEL5
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
YPEL5

No disorders were found for YPEL5 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for YPEL5 Gene

Publications for YPEL5 Gene

  1. Identification and characterization of a novel gene family YPEL in a wide spectrum of eukaryotic species. (PMID: 15556292) Hosono K. … Shimizu N. (Gene 2004) 2 3 4 23 67
  2. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 3
  3. Recurrent reciprocal RNA chimera involving YPEL5 and PPP1CB in chronic lymphocytic leukemia. (PMID: 23382248) Velusamy T. … Elenitoba-Johnson K.S. (Proc. Natl. Acad. Sci. U.S.A. 2013) 3
  4. The SOX2-interactome in brain cancer cells identifies the requirement of MSI2 and USP9X for the growth of brain tumor cells. (PMID: 23667531) Cox J.L. … Rizzino A. (PLoS ONE 2013) 3
  5. Centrosome-related genes, genetic variation, and risk of breast cancer. (PMID: 20508983) Olson J.E. … Couch F.J. (Breast Cancer Res. Treat. 2011) 3

Products for YPEL5 Gene

Sources for YPEL5 Gene

Back to Top

Content