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YPEL4 Gene

protein-coding   GIFtS: 44

GC11M057169
yippee-like 4 (Drosophila)
Symbol approved by the HUGO Gene Nomenclature Committee (HGNC) database
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Aliases &
Descriptions
for YPEL4

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc , and/or 7Ensembl, 8miRBase)
About This Section
Aliases
FLJ30213 1, 2
MGC102723 2
MGC138324 2
Descriptions
yippee-like 4 2
yippee-like 4 (Drosophila) 2
External Ids
HGNC: 183281
Entrez Gene: 2195392
UniProtKB: Q96NS13
Ensembl: ENSG000001667937
Search outside databases for aliases for YPEL4 gene

Summaries
for YPEL4

(According to Entrez Gene, Wikipedia's Gene Wiki,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

   --

Genomic Location
for YPEL4

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 36),
and/or miRBase,
Genomic Views according to UCSC and Ensembl, Transcription factor binding sites according to SABiosciences)
About This Section

 Genomic View:
UCSC Golden Path with GeneCards custom track

 Transcription factor binding sites upstream to the YPEL4 gene  

Entrez Gene cytogenetic band: 11q12.1   Ensembl cytogenetic band:  11q12.1   HGNC cytogenetic band: 11q12

YPEL4 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)

GeneLoc gene densities for chromosome 11         GeneLoc Exon Structure

GeneLoc location for GC11M057169:     (about GC identifiers)

Start:
 57,169,137 bp from pter
End:
 57,173,993 bp from pter
Size:
 4,857 bases
Orientation:
 minus strand
RefSeq DNA sequence:
NC_000011.8  NT_033903.7  

Proteins
for YPEL4

(According to 1UniProtKB, and/or Ensembl, Phosphorylation sites according to 2Phosphosite, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Enzo Life Sciences, Abnova, OriGene and/or, Abcam,
Biochemical Assays by Invitrogen, Millipore, R&D Systems, Cell Signaling Technology, and/or Enzo Life Sciences, Ontologies according to Gene Ontology Consortium 01 Apr 2009 and Entrez Gene, Antibodies by Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Cell Signaling Technology, Abcam, Abnova, and/or Novus Biologicals)
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 UniProtKB/Swiss-Prot: YPEL4_HUMAN, Q96NS1 (See protein sequence)
Recommended Name: Protein yippee-like 4  
Size: 127 amino acids; 14301 Da
Subcellular location: Nucleus, nucleolus
Secondary accessions: Q2M3U7 Q65Z98

REFSEQ proteins: NP_659445.1  

ENSEMBL proteins: 
ENSP00000300022 


Human Recombinant Proteins 
Browse Drug Discovery Central at Invitrogen for human recombinant proteins
Browse Purified and Recombinant Proteins at Millipore
Browse Human Recombinant Proteins at Sigma-Aldrich  
Browse R&D Systems for human recombinant proteins
Browse recombinant and purified proteins available from Enzo Life Sciences
Browse Abcam for Recombinant Proteins
Browse Abnova for Human Recombinant Proteins
              OriGene Purified Recombinant Human Protein: YPEL4 

1 Gene Ontology (GO) cellular component term (links to tree view):

GO IDQualified GO termEvidencePubMed IDs
GO:0005634 nucleus IEA--
About this table

Antibodies for YPEL4: 
Browse Antibodies Central at Invitrogen
Browse Millipore's Extensive Line of Mono- and Polyclonal Antibodies
Browse Antibodies at Sigma-Aldrich
Browse R&D Systems for Antibodies
Search for antibodies at Abcam and the World's Antibody Gateway (free search engine of over 150 antibody companies)
Browse Abnova for Monoclonal and Polyclonal Antibodies
Search Novus for antibodies for YPEL4

Assays for YPEL4: 
Browse Invitrogen for biochemical assays
Browse Kits and Assays available from Millipore
Browse R&D Systems for biochemical assays
Browse biochemical assays available from Enzo Life Sciences

Protein Domains/
Families
for YPEL4

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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1 InterPro domain/family:
 IPR004910 Yippee


   GeneDecks  YPEL4 for the domains selected above  
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Graphical View of Domain Structure for InterPro Entry Q96NS1

ProtoNet protein and cluster: Q96NS1

1 Blocks protein family: IPB004910 Yippee-like protein

UniProtKB/Swiss-Prot: YPEL4_HUMAN, Q96NS1
Similarity: Belongs to the yippee family

Gene Function
for YPEL4

(According to MGI Jun 06 2009, UniProtKB, IUBMB,and/or Genatlas,
shRNA from OriGene, Sigma-Aldrich, RNAi from Sigma-Aldrich,
RNAi Products, Clones, and Q-PCR Products from Invitrogen, Millipore, OriGene, and/or Abnova, siRNAs from Applied Biosystems, SYBR primers from OriGene, Cell-based Assays from Millipore, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
About This Section
Inhib.
RNA:		Invitrogen RNAi Products for gene knock-down (YPEL4)
Browse for Gene Knock-down Tools from Millipore
Browse Abnova for Chimera RNAi Products
              OriGene 29mer shRNA kit in GFP-retroviral vector: NM_145008

              Applied Biosystems Silencer® siRNAs for YPEL4

              Sigma-Aldrich siRNA for YPEL4  
                     Sigma-Aldrich shRNA for YPEL4  
                     Explore Sigma-Aldrich super-pooled esiRNAs  

Clones:Invitrogen Clones for YPEL4
Browse Clones for the Expression of Recombinant Proteins Available from Millipore
              OriGene GFP tagged cDNA clone in CMV expression vector: NM_145008
                                 Myc/DDK tagged cDNA clone in CMV expression vector: NM_145008
                                 untagged cDNA clone in CMV expression vector: NM_145008 

Primers: Browse Quantitative PCR Central at Invitrogen for Q-PCR LUX™ Primers
              OriGene genome-wide validated SYBR primer pairs: NM_145008

Pathways & Interactions
for YPEL4

(Pathways according to Invitrogen (maps by GeneGo), Millipore, Cell Signaling Technology, Sigma-Aldrich, KEGG and/or UniProtKB,
Sets of similar genes according to GeneDecks, Proteins Network according to SABiosciences, Interactions according to 1UniProtKB, 2MINT, and/or 3STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
About This Section


  --

Drugs & Compounds
for YPEL4

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, Sigma-Aldrich, Tocris Bioscience, and/or Novoseek and Drugs according to Enzo Life Sciences and/or PharmGKB)
About This Section

Browse drugs & compounds from Enzo Life Sciences
Browse Small Molecules at Sigma-Aldrich

Browse Tocris compounds for YPEL4

Transcripts
for YPEL4

(GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 219 Homo sapiens; Jun 2 2009) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView,
non coding RNAs according to RNAdb,
ESTs according to GeneTide,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from Invitrogen, Millipore, and/or Abnova,
siRNAs from Applied Biosystems, Sigma-Aldrich,
shRNA from Sigma-Aldrich, OriGene,
Tagged/untagged cDNA clones from OriGene,
Expression Assays from Applied Biosystems)
About This Section
Inhib.
RNA:		Invitrogen RNAi Products for gene knock-down (YPEL4)
Browse for Gene Knock-down Tools from Millipore
Browse Abnova for Chimera RNAi Products
              OriGene 29mer shRNA kit in GFP-retroviral vector: NM_145008

              Sigma-Aldrich siRNA for YPEL4  
                     Sigma-Aldrich shRNA for YPEL4  
                     Explore Sigma-Aldrich super-pooled esiRNAs  

Applied Biosystems Silencer® siRNAs: 

NM_145008  

REFSEQ mRNAs for YPEL4 gene: 

NM_145008.2   

Applied Biosystems TaqMan ® Gene Expression Assays: 

NM_145008  

              OriGene GFP tagged cDNA clone in CMV expression vector: NM_145008
                                 Myc/DDK tagged cDNA clone in CMV expression vector: NM_145008
                                 untagged cDNA clone in CMV expression vector: NM_145008 

Additional cDNA sequence: 

AB098738.1 AK054775.1 AK054967.1 AK124577.1 BC029228.1 BC064995.1 BC104781.1 BC111012.1 
BC112119.1 

6 DOTS entries:

DT.307333  DT.91868052  DT.100018472  DT.307334  DT.97838041  DT.100738138 

24/40 AceView cDNA sequences (see all 40 ):

BX106972 BU732730 AK124577 BC029228 NM_145008 BM698861 BE673815 BM669646 
AK054775 BU688993 BM709355 AI703426 BC064995 BM926759 BI754146 W00827 
BI489821 BM922142 AK054967 BF874997 BF876018 BI754648 AW873586 BF842399 

highest scoring ESTs for YPEL4:

AI703426 AK054775 AK124577 BC029228 BC064995 BI754146 BX442580 AI216256 AK054967 AW016769 

Unigene Cluster for YPEL4:

Yippee-like 4 (Drosophila)
Hs.135978  [show with all ESTs]
Unigene Representative Sequence: AK124577


GeneLoc Exon Structure

5/6 Alternative Splicing Database (ASD) splice patterns (SP) for YPEL4 (see all 6 )

ExUns: 1a · 1b ^ 2a · 2b · 2c · 2d ^ 3a · 3b ^ 4a · 4b ^ 5
SP1:              -     -           -           -                     
SP2:                                -           -                     
SP3:              -     -           -                                 
SP4:                                -                                 
SP5:                                -     -     -                     

About this scheme

ECgene alternative splicing isoforms for YPEL4

1 Ensembl transcript including schematic representation:
ENST00000300022  

Expression
for YPEL4

(Experimental results according to 1GeneNote and GNF BioGPS,
probe sets-to-genes annotations according to 2GeneAnnot , 3GeneTide , Sets of similar genes according to GeneDecks, Electronic Northern calculations according to data from UniGene (Build 219 Homo sapiens), SAGE tags according to CGAP, plus additional links to SOURCE, and/or GNF BioGPS, and/or EXPOLDB, and/or UniProtKB,
Expression Assays from Applied Biosystems )
About This Section

YPEL4 expression in normal and diseased human tissues

 Applied Biosystems TaqMan ® Gene Expression Assays for YPEL4

1 / 2 / 3

3 probe-sets matching YPEL4 gene


Affymetrix
probe-set		 Array  GeneAnnot data GeneNote data GeneTide data
# genes Sensitivity Specificity Correlation Length Gb_Accession Consensus Uniqueness Score Rank
48382_at2, 3 U95-B 1 1.00 1.00 1.00 1.00 AI703426 0.80 1.00 0.91 1

235916_at2, 3 U133-B 1 1.00 1.00 -- -- BE673815 0.60 1.00 0.82 1

235916_at2 U133Plus2 1 1.00 1.00 -- -- -- -- -- -- --
GeneDecks  YPEL4 for binary patterns associated with the probe-sets selected above  
About GeneDecksing
About this table    
Data from (Publications) and GNF BioGPS
    About these images
About these images

CGAP SAGE TAG: GACCACAGAA

SOURCE GeneReport for Unigene cluster: Hs.135978

UniProtKB/Swiss-Prot: YPEL4_HUMAN, Q96NS1
Tissue specificity: Widely expressed. Detected adult brain, lung, colon, small intestine and ovary,
and in fetal brain, lung, liver and spleen

Orthologs
for YPEL4

(Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD and/or 5MGI Jun 06 2009, with possible further links to Flybase and/or WormBase, Gene Trees according to Ensembl)
About This Section
Orthologs for YPEL4 gene from 5/10 species (see all 10 )
Organism Gene Locus Description Human
Similarity		 NCBI accessions
dog
(Canis familiaris)		 YPEL41   -- yippee-like 4 (Drosophila) 92.91(n)
99.21(a)		 610168  XM_847589.1  XP_852682.1 
chimpanzee
(Pan troglodytes)		 YPEL41   -- yippee-like 4 (Drosophila) 99.74(n)
100(a)		 451197  XM_001138848.1  XP_001138848.1 
rat
(Rattus norvegicus)		 Ypel41   -- yippee-like 4 (Drosophila) 91.34(n)
99.21(a)		 502643  NM_001024369.1  NP_001019540.1 
mouse
(Mus musculus)		 Ypel41, 5 25
 yippee-like 4 (Drosophila)1, 5 91.08(n)1
99.21(a)1		 2415251  NM_001005342.21  NP_001005342.11 
 AB0987435  AK0435775  (see all 7)
zebrafish
(Danio rerio)		 ypel31   -- yippee-like 3 78.57(n)
84.82(a)		 368214  NM_212790.1  NP_997955.1 
About this table        Species with no ortholog for YPEL4

ENSEMBL Gene Tree for YPEL4

Paralogs
for YPEL4

(Paralogs according to 1HomoloGene
and 2Ensembl, Pseudogenes according to 3Pseudogene.org)
About This Section

Paralogs for YPEL4 gene
YPEL12  YPEL32  YPEL22  YPEL52  

SNPs/Variants
for YPEL4

(According to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, and UniProtKB, Linkage Disequilibrium by HapMap, Genotyping Reagents from Applied Biosystems)
About This Section


10/16 NCBI SNPs in YPEL4 are shown (see all 16 )
(Click for Applied Biosystems TaqMan ® Genotyping Assay)  (see all 36)
ABGenomic DataTranscription DataAllele Frequencies
SNP IDValidChr 11 posSequenceRecsAA
Chg		TypeMoreRecsAllele
freq		PopTotal
sample		More
------------
rs17981771,2
A,C,F,H,O57168726(+) GCTGAT/CTGATT 1 -- ng517Minor allele frequency- C:0.20EU EA WA NA 558
rs20768951,2
A,C,F,H57169548(+) TCATCC/TTCAGA 1 -- ut31 ese34Minor allele frequency- T:0.03EU EA WA 412
--
rs16473941,2
C,F57175164(-) ctgcaA/Gctggt 1 -- ng313Minor allele frequency- G:0.20NA 134
rs122781621,2
F,H57169741(+) GCCATC/TGCTTC 1 -- ut314Minor allele frequency- T:0.01EU EA WA 388
rs74793231,2
H57169888(+) TAGTGG/TATATG 1 -- ut31 ese34Minor allele frequency- T:0.00EU EA WA 420
--
rs71081131,2
A57175925(+) atcccG/Tctaga 1 -- ng310--------
rs122947351,2
A,C,F,H57171970(+) CTCACG/ATGTGG 1 -- int1 ese311Minor allele frequency- A:0.07EU EA WA NA 980
rs8900361,2
A,C,F,H57170296(-) CATGGC/TCCTTC 1 -- int16Minor allele frequency- T:0.09NA EU EA WA 582
rs79473571,2
A,C,F,H57170963(+) TGTTCG/AGGCTA 1 -- int16Minor allele frequency- A:0.38EU EA WA NA 594
rs127931391,2
C,F,H57170519(+) CCAGAG/CAGCCC 1 -- int112Minor allele frequency- C:0.47EU EA WA NA 1148
About this table

HapMap Linkage Disequilibrium images for YPEL4 (up to first 250kb)

Disorders & Mutations
for YPEL4

(in which this Gene is Involved, According to OMIM, UniProtKB, PharmGKB, Genatlas, GeneTests, Blood group antigen gene mutations by BGMUT, HGMD, GAD, HuGE Navigator, BCGD, and/or TGDB.)
About This Section

 OMIM: 609725

Medical News
for YPEL4

(Possibly Related Articles in Doctor's Guide)
About This Section

   --

Publications
for YPEL4

(in PubMed. Associations of this gene to articles via 1Novoseek, 2HGNC, 3Entrez Gene, 4UniProtKB/Swiss-Prot, 5UniProtKB/TrEMBL, 6GAD, and/or 7PharmGKB)
About This Section

4 PubMed articles for YPEL4 gene:

Search for YPEL4

(in PubMed, OMIM, and NCBI Bookshelf)
About This Section

 ANDOR
Aliases
Free Text  
  Query String
PubMed
OMIM
NCBI Bookshelf
  (Note: In FireFox, select the above section and copy using Ctrl-C)

Genome Databases showing YPEL4

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, and/or H-InvDB)
About This Section
Entrez Gene: 219539 HGNC: 18328 AceView: YPEL4 Ensembl:ENSG00000166793 euGenes: HUgn219539
ECgene: YPEL4 H-InvDB: YPEL4

Other Databases showing YPEL4

(According to HUGE)
About This Section

   --

Specialized Databases showing YPEL4

(According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section

   --

Licensable Technologies
for YPEL4

(Available from WIS Yeda, Salk, Tufts)
About This Section

  --

Services
for YPEL4

(Reagents available from Applied Biosystems, Antibodies and assays by Cell Signaling Technology, Abcam, Novus Biologicals,
Sigma-Aldrich, R&D Systems, Millipore, Abnova, and/or Invitrogen, Clones available from OriGene,and/or Invitrogen, Drugs and/or compounds by Sigma-Aldrich,
Enzo Life Sciences, and/or Tocris Bioscience)
About This Section



Products for YPEL4:
 TaqMan ® Gene Expression Assays
 TaqMan ® Genotyping Assays
  Free SNP selection tool



  Invitrogen iPath Pathways  Invitrogen BLOCK-iT™ RNAi
  Invitrogen Antibodies  Invitrogen Assays
  Invitrogen Clones  Invitrogen Q-PCR Products
  Invitrogen Human Recombinant Kinases  Invitrogen Custom Antibody and Peptide Service
  Invitrogen Proteins / Assays / Screening Services  Search Invitrogen catalog for YPEL4-related products

 Millipore Custom Antibody & Bulk Services
 Millipore Preclinical / Clinical Development Services
 Millipore Immunoassay Services
 Millipore Target Screening & Profiling Services


 Predesigned and custom siRNAs for YPEL4 Browse antibodies at Sigma-Aldrich
 Explore super-pooled esiRNAs Browse proteins at Sigma-Aldrich
 Lentivirus-delivered shRNAs for YPEL4 Browse small molecules at Sigma-Aldrich
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 Search Novus for antibodies for YPEL4

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