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Aliases for YPEL4 Gene

Aliases for YPEL4 Gene

  • Yippee-Like 4 (Drosophila) 2 3

External Ids for YPEL4 Gene

Summaries for YPEL4 Gene

GeneCards Summary for YPEL4 Gene

YPEL4 (Yippee-Like 4 (Drosophila)) is a Protein Coding gene. An important paralog of this gene is YPEL2.

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for YPEL4 Gene

Genomics for YPEL4 Gene

Genomic Location for YPEL4 Gene

Start:
57,645,087 bp from pter
End:
57,649,944 bp from pter
Size:
4,858 bases
Orientation:
Minus strand

Genomic View for YPEL4 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for YPEL4 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for YPEL4 Gene

Regulatory Elements for YPEL4 Gene

Proteins for YPEL4 Gene

  • Protein details for YPEL4 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q96NS1-YPEL4_HUMAN
    Recommended name:
    Protein yippee-like 4
    Protein Accession:
    Q96NS1
    Secondary Accessions:
    • B3KW92
    • Q2M3U7
    • Q65Z98

    Protein attributes for YPEL4 Gene

    Size:
    127 amino acids
    Molecular mass:
    14301 Da
    Quaternary structure:
    No Data Available

neXtProt entry for YPEL4 Gene

Proteomics data for YPEL4 Gene at MOPED

Post-translational modifications for YPEL4 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for YPEL4 Gene

No data available for DME Specific Peptides for YPEL4 Gene

Domains for YPEL4 Gene

Protein Domains for YPEL4 Gene

InterPro:
Blocks:
ProtoNet:

UniProtKB/Swiss-Prot:

YPEL4_HUMAN
Family:
  • Belongs to the yippee family.:
    • Q96NS1
genes like me logo Genes that share domains with YPEL4: view

No data available for Gene Families for YPEL4 Gene

Function for YPEL4 Gene

Phenotypes for YPEL4 Gene

GenomeRNAi human phenotypes for YPEL4:
genes like me logo Genes that share phenotypes with YPEL4: view

miRNA for YPEL4 Gene

miRTarBase miRNAs that target YPEL4

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Animal Models , Transcription Factor Targeting and HOMER Transcription for YPEL4 Gene

Localization for YPEL4 Gene

Subcellular locations from UniProtKB/Swiss-Prot for YPEL4 Gene

Nucleus, nucleolus.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for YPEL4 Gene COMPARTMENTS Subcellular localization image for YPEL4 gene
Compartment Confidence
nucleus 5
extracellular 2
mitochondrion 2
cytosol 1

Gene Ontology (GO) - Cellular Components for YPEL4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus --
GO:0005730 nucleolus IEA --
genes like me logo Genes that share ontologies with YPEL4: view

Pathways for YPEL4 Gene

SuperPathways for YPEL4 Gene

No Data Available

Gene Ontology (GO) - Biological Process for YPEL4 Gene

None

No data available for Pathways by source for YPEL4 Gene

Transcripts for YPEL4 Gene

Unigene Clusters for YPEL4 Gene

Yippee-like 4 (Drosophila):
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for YPEL4 Gene

ExUns: 1a · 1b ^ 2a · 2b · 2c · 2d ^ 3a · 3b ^ 4a · 4b ^ 5
SP1: - - - -
SP2: - -
SP3: - - -
SP4: -
SP5: - - -
SP6: -

Relevant External Links for YPEL4 Gene

GeneLoc Exon Structure for
YPEL4
ECgene alternative splicing isoforms for
YPEL4

Expression for YPEL4 Gene

mRNA expression in normal human tissues for YPEL4 Gene

mRNA differential expression in normal tissues according to GTEx for YPEL4 Gene

This gene is overexpressed in Brain - Cerebellum (6.1), Brain - Cerebellar Hemisphere (5.8), Brain - Cortex (5.0), and Brain - Frontal Cortex (BA9) (4.2).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, and MOPED for YPEL4 Gene

SOURCE GeneReport for Unigene cluster for YPEL4 Gene Hs.135978

mRNA Expression by UniProt/SwissProt for YPEL4 Gene

Q96NS1-YPEL4_HUMAN
Tissue specificity: Widely expressed. Detected adult brain, lung, colon, small intestine and ovary, and in fetal brain, lung, liver and spleen.
genes like me logo Genes that share expressions with YPEL4: view

Orthologs for YPEL4 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for YPEL4 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia YPEL4 36
  • 99.74 (n)
  • 100 (a)
YPEL4 37
  • 100 (a)
OneToOne
dog
(Canis familiaris)
Mammalia YPEL4 36
  • 92.91 (n)
  • 99.21 (a)
YPEL4 37
  • 99 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Ypel4 36
  • 91.08 (n)
  • 99.21 (a)
Ypel4 16
Ypel4 37
  • 99 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia YPEL4 37
  • 99 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia YPEL4 37
  • 97 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Ypel4 36
  • 91.34 (n)
  • 99.21 (a)
chicken
(Gallus gallus)
Aves LOC100858042 36
  • 83.06 (n)
  • 89.17 (a)
YPEL4 37
  • 66 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia YPEL4 37
  • 96 (a)
OneToOne
zebrafish
(Danio rerio)
Actinopterygii ypel3 36
  • 77.78 (n)
  • 83.33 (a)
ypel3 37
  • 80 (a)
OneToMany
fruit fly
(Drosophila melanogaster)
Insecta CG15309 37
  • 76 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea F37A8.5 37
  • 66 (a)
OneToMany
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes MOH1 37
  • 36 (a)
OneToMany
soybean
(Glycine max)
eudicotyledons Gma.4134 36
thale cress
(Arabidopsis thaliana)
eudicotyledons AT3G08990 36
  • 60.3 (n)
  • 58.43 (a)
corn
(Zea mays)
Liliopsida Zm.5188 36
sea squirt
(Ciona savignyi)
Ascidiacea -- 37
  • 74 (a)
OneToMany
Species with no ortholog for YPEL4:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • cow (Bos Taurus)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)

Evolution for YPEL4 Gene

ENSEMBL:
Gene Tree for YPEL4 (if available)
TreeFam:
Gene Tree for YPEL4 (if available)

Paralogs for YPEL4 Gene

Paralogs for YPEL4 Gene

Selected SIMAP similar genes for YPEL4 Gene using alignment to 4 proteins:

genes like me logo Genes that share paralogs with YPEL4: view

Variants for YPEL4 Gene

Sequence variations from dbSNP and Humsavar for YPEL4 Gene

SNP ID Clin Chr 11 pos Sequence Context AA Info Type MAF
rs890036 -- 57,646,247(-) CATGG(C/T)CCTTC intron-variant
rs1647394 -- 57,651,115(-) ctgca(A/G)ctggt upstream-variant-2KB
rs1798177 -- 57,644,677(+) GCTGA(C/T)TGATT downstream-variant-500B
rs2076895 -- 57,645,499(+) TCATC(C/T)TCAGA utr-variant-3-prime
rs7108113 -- 57,651,876(+) atccc(G/T)ctaga upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for YPEL4 Gene

Variant ID Type Subtype PubMed ID
nsv832163 CNV Gain 17160897
nsv832164 CNV Loss 17160897
esv992553 CNV Deletion 20482838

Relevant External Links for YPEL4 Gene

HapMap Linkage Disequilibrium report
YPEL4

Disorders for YPEL4 Gene

Relevant External Links for YPEL4

Genetic Association Database (GAD)
YPEL4
Human Genome Epidemiology (HuGE) Navigator
YPEL4
genes like me logo Genes that share disorders with YPEL4: view

No data available for UniProtKB/Swiss-Prot for YPEL4 Gene

Publications for YPEL4 Gene

  1. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4
  2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4
  3. Identification and characterization of a novel gene family YPEL in a wide spectrum of eukaryotic species. (PMID: 15556292) Hosono K. … Shimizu N. (Gene 2004) 3 4
  4. Centrosome-related genes, genetic variation, and risk of breast cancer. (PMID: 20508983) Olson J.E. … Couch F.J. (Breast Cancer Res. Treat. 2011) 3 49
  5. MVP interacts with YPEL4 and inhibits YPEL4-mediated activities of the ERK signal pathway. (PMID: 20555386) Liang P. … Wu X. (Biochem. Cell Biol. 2010) 3

Products for YPEL4 Gene

Sources for YPEL4 Gene

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