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Aliases for YPEL3 Gene

Aliases for YPEL3 Gene

  • Yippee Like 3 2 3 5
  • Yippee-Like 3 (Drosophila) 2

External Ids for YPEL3 Gene

Previous GeneCards Identifiers for YPEL3 Gene

  • GC16M030011
  • GC16M027764

Summaries for YPEL3 Gene

GeneCards Summary for YPEL3 Gene

YPEL3 (Yippee Like 3) is a Protein Coding gene. An important paralog of this gene is YPEL2.

UniProtKB/Swiss-Prot for YPEL3 Gene

  • Involved in proliferation and apoptosis in myeloid precursor cells.

Additional gene information for YPEL3 Gene

No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for YPEL3 Gene

Genomics for YPEL3 Gene

Regulatory Elements for YPEL3 Gene

Enhancers for YPEL3 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH16H030074 1.3 ENCODE dbSUPER 38.3 +20.2 20231 4.6 ARID4B SIN3A DMAP1 ZNF2 YY1 ZNF143 ZHX2 REST ZNF592 KAT8 YPEL3 SRCAP SETD1A GDPD3 ZNF764 SMG1P5 ENSG00000198106 INO80E SMG1P2 NPIPB12
GH16H030059 1.3 Ensembl ENCODE dbSUPER 36.7 +35.8 35849 2.7 HDAC1 PKNOX1 NFIB KLF17 TCF12 RCOR1 ZNF398 ZNF217 NFIC ZSCAN16 YPEL3 ENSG00000274904 ALDOA
GH16H030063 1.4 ENCODE dbSUPER 32.5 +31.3 31296 4.9 MLX ZFP64 FEZF1 DMAP1 YY1 SLC30A9 ZNF143 SP3 NFYC ZC3H11A YPEL3 SETD1A RNF40 SMG1P5 ZNF747 SMG1P2 INO80E SRCAP CA5AP1 LOC647086
GH16H030030 1.2 Ensembl ENCODE 36.2 +65.6 65587 2.7 RB1 ARID4B KLF17 FEZF1 DMAP1 ZNF2 RAD21 SLC30A9 ZNF143 ZNF391 YPEL3 GC16M030027 GC16P030051
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around YPEL3 on UCSC Golden Path with GeneCards custom track

Promoters for YPEL3 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000085154 815 1001 HDGF ARID4B SIN3A DMAP1 ZNF2 ZNF121 SLC30A9 CBX5 ELK1 ZNF143

Transcription factor binding sites by QIAGEN in the YPEL3 gene promoter:

Genomic Locations for YPEL3 Gene

Genomic Locations for YPEL3 Gene
4,602 bases
Minus strand

Genomic View for YPEL3 Gene

Genes around YPEL3 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
YPEL3 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for YPEL3 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for YPEL3 Gene

Proteins for YPEL3 Gene

  • Protein details for YPEL3 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Protein yippee-like 3
    Protein Accession:
    Secondary Accessions:
    • Q65Z99
    • Q86VK6
    • Q9BSJ4
    • Q9CQB6

    Protein attributes for YPEL3 Gene

    119 amino acids
    Molecular mass:
    13608 Da
    Quaternary structure:
    No Data Available
    • Sequence=EAW79925.1; Type=Erroneous initiation; Evidence={ECO:0000305};

    Alternative splice isoforms for YPEL3 Gene


neXtProt entry for YPEL3 Gene

Post-translational modifications for YPEL3 Gene

No data available for DME Specific Peptides for YPEL3 Gene

Domains & Families for YPEL3 Gene

Gene Families for YPEL3 Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Protein Domains for YPEL3 Gene

Suggested Antigen Peptide Sequences for YPEL3 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the yippee family.
  • Belongs to the yippee family.
genes like me logo Genes that share domains with YPEL3: view

Function for YPEL3 Gene

Molecular function for YPEL3 Gene

UniProtKB/Swiss-Prot Function:
Involved in proliferation and apoptosis in myeloid precursor cells.

Phenotypes From GWAS Catalog for YPEL3 Gene

Gene Ontology (GO) - Molecular Function for YPEL3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0046872 metal ion binding IEA --
genes like me logo Genes that share ontologies with YPEL3: view
genes like me logo Genes that share phenotypes with YPEL3: view

Animal Models for YPEL3 Gene

MGI Knock Outs for YPEL3:

Animal Model Products

CRISPR Products

miRNA for YPEL3 Gene

miRTarBase miRNAs that target YPEL3

Inhibitory RNA Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for YPEL3 Gene

Localization for YPEL3 Gene

Subcellular locations from UniProtKB/Swiss-Prot for YPEL3 Gene

Nucleus, nucleolus.

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for YPEL3 gene
Compartment Confidence
nucleus 3
extracellular 2
mitochondrion 2
cytosol 1

Gene Ontology (GO) - Cellular Components for YPEL3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005730 nucleolus IEA --
genes like me logo Genes that share ontologies with YPEL3: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for YPEL3 Gene

Pathways & Interactions for YPEL3 Gene

SuperPathways for YPEL3 Gene

No Data Available

Gene Ontology (GO) - Biological Process for YPEL3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:2000774 positive regulation of cellular senescence IDA 20388804
genes like me logo Genes that share ontologies with YPEL3: view

No data available for Pathways by source and SIGNOR curated interactions for YPEL3 Gene

Drugs & Compounds for YPEL3 Gene

No Compound Related Data Available

Transcripts for YPEL3 Gene

Unigene Clusters for YPEL3 Gene

Yippee-like 3 (Drosophila):
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Alternative Splicing Database (ASD) splice patterns (SP) for YPEL3 Gene

ExUns: 1 ^ 2a · 2b ^ 3a · 3b · 3c · 3d ^ 4a · 4b · 4c ^ 5a · 5b · 5c ^ 6a · 6b · 6c
SP1: - - - - - - -
SP2: - - - - -
SP3: - - -
SP4: - - - - -
SP5: - - -
SP6: - -

Relevant External Links for YPEL3 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for YPEL3 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for YPEL3 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for YPEL3 Gene

This gene is overexpressed in Whole Blood (x8.6).

Protein differential expression in normal tissues from HIPED for YPEL3 Gene

This gene is overexpressed in Platelet (44.9) and Heart (24.1).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for YPEL3 Gene

Protein tissue co-expression partners for YPEL3 Gene

NURSA nuclear receptor signaling pathways regulating expression of YPEL3 Gene:


SOURCE GeneReport for Unigene cluster for YPEL3 Gene:


mRNA Expression by UniProt/SwissProt for YPEL3 Gene:

Tissue specificity: Widely expressed.

Evidence on tissue expression from TISSUES for YPEL3 Gene

  • Pancreas(4.2)
genes like me logo Genes that share expression patterns with YPEL3: view

No data available for Phenotype-based relationships between genes and organs from Gene ORGANizer for YPEL3 Gene

Orthologs for YPEL3 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for YPEL3 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia YPEL3 33 34
  • 99.44 (n)
(Canis familiaris)
Mammalia YPEL3 33 34
  • 98.04 (n)
(Bos Taurus)
Mammalia YPEL3 33 34
  • 97.48 (n)
(Mus musculus)
Mammalia Ypel3 33 16 34
  • 95.52 (n)
(Rattus norvegicus)
Mammalia Ypel3 33
  • 95.24 (n)
(Monodelphis domestica)
Mammalia YPEL3 34
  • 90 (a)
African clawed frog
(Xenopus laevis)
Amphibia Xl.9405 33
(Danio rerio)
Actinopterygii ypel3 34
  • 90 (a)
LOC561851 33
  • 78.43 (n)
fruit fly
(Drosophila melanogaster)
Insecta CG15309 34
  • 82 (a)
(Caenorhabditis elegans)
Secernentea F37A8.5 33 34
  • 70.47 (n)
A. gosspyii yeast
(Ashbya gossypii)
Saccharomycetes AGOS_ABR153C 33
  • 54.68 (n)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes MOH1 33 34
  • 51.77 (n)
K. lactis yeast
(Kluyveromyces lactis)
Saccharomycetes KLLA0E05875g 33
  • 49.07 (n)
thale cress
(Arabidopsis thaliana)
eudicotyledons AT3G11230 33
  • 58.89 (n)
(Hordeum vulgare)
Liliopsida Hv.6839 33
sea squirt
(Ciona savignyi)
Ascidiacea -- 34
  • 79 (a)
bread mold
(Neurospora crassa)
Ascomycetes NCU00024 33
  • 60.54 (n)
fission yeast
(Schizosaccharomyces pombe)
Schizosaccharomycetes SPAPJ691.02 33
  • 47.1 (n)
Species where no ortholog for YPEL3 was found in the sources mined by GeneCards:
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • beta proteobacteria (Neisseria meningitidis)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)

Evolution for YPEL3 Gene

Gene Tree for YPEL3 (if available)
Gene Tree for YPEL3 (if available)

Paralogs for YPEL3 Gene

Paralogs for YPEL3 Gene

(4) SIMAP similar genes for YPEL3 Gene using alignment to 5 proteins:

genes like me logo Genes that share paralogs with YPEL3: view

Variants for YPEL3 Gene

Sequence variations from dbSNP and Humsavar for YPEL3 Gene

SNP ID Clin Chr 16 pos Sequence Context AA Info Type
rs1000060529 -- 30,094,596(+) CTGGG(A/G)GAGAA intron-variant, upstream-variant-2KB
rs1000305364 -- 30,093,887(+) CTGGC(C/T)GGCCA intron-variant, upstream-variant-2KB
rs1001016523 -- 30,096,114(+) CGCGG(A/G)GCCCG upstream-variant-2KB, utr-variant-5-prime
rs1001460360 -- 30,094,350(+) ACCAA(C/G)CAACT intron-variant
rs1001565006 -- 30,095,198(+) GTGGG(A/G)AGCTG intron-variant, upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for YPEL3 Gene

Variant ID Type Subtype PubMed ID
nsv833187 CNV loss 17160897
nsv1160384 CNV duplication 26073780
esv2758642 CNV gain 17122850

Variation tolerance for YPEL3 Gene

Residual Variation Intolerance Score: 46.5% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.85; 17.75% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for YPEL3 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for YPEL3 Gene

Disorders for YPEL3 Gene

Relevant External Links for YPEL3

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator
Atlas of Genetics and Cytogenetics in Oncology and Haematology:

No disorders were found for YPEL3 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for YPEL3 Gene

Publications for YPEL3 Gene

  1. Identification and characterization of a novel gene family YPEL in a wide spectrum of eukaryotic species. (PMID: 15556292) Hosono K … Shimizu N (Gene 2004) 2 3 4 60
  2. Centrosome-related genes, genetic variation, and risk of breast cancer. (PMID: 20508983) Olson JE … Couch FJ (Breast cancer research and treatment 2011) 3 45 60
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 60
  4. Architecture of the human interactome defines protein communities and disease networks. (PMID: 28514442) Huttlin EL … Harper JW (Nature 2017) 3 60
  5. Phospho-tyrosine dependent protein-protein interaction network. (PMID: 25814554) Grossmann A … Stelzl U (Molecular systems biology 2015) 3 60

Products for YPEL3 Gene

Sources for YPEL3 Gene

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