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Aliases for YPEL3 Gene

Aliases for YPEL3 Gene

  • Yippee Like 3 2 3 5
  • Yippee-Like 3 (Drosophila) 2

External Ids for YPEL3 Gene

Previous GeneCards Identifiers for YPEL3 Gene

  • GC16M030011
  • GC16M027764

Summaries for YPEL3 Gene

GeneCards Summary for YPEL3 Gene

YPEL3 (Yippee Like 3) is a Protein Coding gene. An important paralog of this gene is YPEL2.

UniProtKB/Swiss-Prot for YPEL3 Gene

  • Involved in proliferation and apoptosis in myeloid precursor cells.

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for YPEL3 Gene

Genomics for YPEL3 Gene

Regulatory Elements for YPEL3 Gene

Enhancers for YPEL3 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH16F030089 1.2 ENCODE 39.4 +3.4 3423 8.1 CREB3L1 MLX DMAP1 SLC30A9 ZNF143 SP3 NFYC TBX21 MEF2D SSRP1 SMG1P2 YPEL3 ZNF764 ZNF785 CD2BP2 TBX6 BCL7C PRR14 ORAI3 MIR762HG
GH16F030059 1.2 Ensembl ENCODE 36.7 +35.8 35849 2.7 HDAC1 PKNOX1 KLF17 RAD21 RARA ZNF121 GATA2 RCOR1 ZNF263 SMAD5 YPEL3 ENSG00000274904 ALDOA
GH16F030074 1.1 ENCODE 38.3 +20.2 20231 4.6 PKNOX1 CREB3L1 ARID4B SIN3A DMAP1 ZNF2 YY1 FOS ZNF263 MXD4 YPEL3 GDPD3 DOC2A TBC1D10B MIR762HG ZNF689 PPP4C TBX6
GH16F030063 1.2 ENCODE 32.5 +31.3 31296 4.9 MLX CREB3L1 ZFP64 FEZF1 DMAP1 YY1 SLC30A9 ZNF143 ZNF263 SP3 YPEL3 SMG1P2 CA5AP1 ENSG00000247735 PRR14 ZNF771 ENSG00000274904 PIR61223
GH16F030102 0.9 ENCODE 38.2 -7.0 -7013 3.0 PKNOX1 SREBF2 ARID4B SIN3A ZNF48 ZNF121 ZNF366 SCRT2 HSF1 ZNF207 YPEL3 PPP4C ENSG00000247735 TBC1D10B ZNF764 ZNF771 ENSG00000261367
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around YPEL3 on UCSC Golden Path with GeneCards custom track

Promoters for YPEL3 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00001504677 815 1801 HDGF ARNT CREB3L1 ARID4B SIN3A DMAP1 ZNF2 SLC30A9 ZNF143 ZNF207

Genomic Location for YPEL3 Gene

Chromosome:
16
Start:
30,092,314 bp from pter
End:
30,096,915 bp from pter
Size:
4,602 bases
Orientation:
Minus strand

Genomic View for YPEL3 Gene

Genes around YPEL3 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
YPEL3 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for YPEL3 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for YPEL3 Gene

Proteins for YPEL3 Gene

  • Protein details for YPEL3 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P61236-YPEL3_HUMAN
    Recommended name:
    Protein yippee-like 3
    Protein Accession:
    P61236
    Secondary Accessions:
    • Q65Z99
    • Q86VK6
    • Q9BSJ4
    • Q9CQB6

    Protein attributes for YPEL3 Gene

    Size:
    119 amino acids
    Molecular mass:
    13608 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=EAW79925.1; Type=Erroneous initiation; Evidence={ECO:0000305};

    Alternative splice isoforms for YPEL3 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for YPEL3 Gene

Post-translational modifications for YPEL3 Gene

No data available for DME Specific Peptides for YPEL3 Gene

Domains & Families for YPEL3 Gene

Gene Families for YPEL3 Gene

Protein Domains for YPEL3 Gene

Suggested Antigen Peptide Sequences for YPEL3 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

P61236

UniProtKB/Swiss-Prot:

YPEL3_HUMAN :
  • Contains 1 Yippee domain.
  • Belongs to the yippee family.
Domain:
  • Contains 1 Yippee domain.
Family:
  • Belongs to the yippee family.
genes like me logo Genes that share domains with YPEL3: view

Function for YPEL3 Gene

Molecular function for YPEL3 Gene

UniProtKB/Swiss-Prot Function:
Involved in proliferation and apoptosis in myeloid precursor cells.

Gene Ontology (GO) - Molecular Function for YPEL3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0046872 metal ion binding IEA --
genes like me logo Genes that share ontologies with YPEL3: view

Phenotypes for YPEL3 Gene

genes like me logo Genes that share phenotypes with YPEL3: view

Animal Models for YPEL3 Gene

MGI Knock Outs for YPEL3:

Animal Model Products

miRNA for YPEL3 Gene

miRTarBase miRNAs that target YPEL3

Inhibitory RNA Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for YPEL3 Gene

Localization for YPEL3 Gene

Subcellular locations from UniProtKB/Swiss-Prot for YPEL3 Gene

Nucleus, nucleolus.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for YPEL3 gene
Compartment Confidence
nucleus 3
extracellular 2
mitochondrion 2
cytosol 1

Gene Ontology (GO) - Cellular Components for YPEL3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005730 nucleolus IEA --
genes like me logo Genes that share ontologies with YPEL3: view

Pathways & Interactions for YPEL3 Gene

SuperPathways for YPEL3 Gene

No Data Available

Gene Ontology (GO) - Biological Process for YPEL3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:2000774 positive regulation of cellular senescence IDA 20388804
genes like me logo Genes that share ontologies with YPEL3: view

No data available for Pathways by source and SIGNOR curated interactions for YPEL3 Gene

Transcripts for YPEL3 Gene

Unigene Clusters for YPEL3 Gene

Yippee-like 3 (Drosophila):
Representative Sequences:

Inhibitory RNA Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for YPEL3 Gene

ExUns: 1 ^ 2a · 2b ^ 3a · 3b · 3c · 3d ^ 4a · 4b · 4c ^ 5a · 5b · 5c ^ 6a · 6b · 6c
SP1: - - - - - - -
SP2: - - - - -
SP3: - - -
SP4: - - - - -
SP5: - - -
SP6: - -
SP7:

Relevant External Links for YPEL3 Gene

GeneLoc Exon Structure for
YPEL3
ECgene alternative splicing isoforms for
YPEL3

Expression for YPEL3 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for YPEL3 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for YPEL3 Gene

This gene is overexpressed in Whole Blood (x8.6).

Protein differential expression in normal tissues from HIPED for YPEL3 Gene

This gene is overexpressed in Platelet (44.9) and Heart (24.1).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for YPEL3 Gene



Protein tissue co-expression partners for YPEL3 Gene

NURSA nuclear receptor signaling pathways regulating expression of YPEL3 Gene:

YPEL3

SOURCE GeneReport for Unigene cluster for YPEL3 Gene:

Hs.513491

mRNA Expression by UniProt/SwissProt for YPEL3 Gene:

P61236-YPEL3_HUMAN
Tissue specificity: Widely expressed.
genes like me logo Genes that share expression patterns with YPEL3: view

Primer Products

Orthologs for YPEL3 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for YPEL3 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia YPEL3 34 35
  • 99.44 (n)
dog
(Canis familiaris)
Mammalia YPEL3 34 35
  • 98.04 (n)
cow
(Bos Taurus)
Mammalia YPEL3 34 35
  • 97.48 (n)
mouse
(Mus musculus)
Mammalia Ypel3 34 16 35
  • 95.52 (n)
rat
(Rattus norvegicus)
Mammalia Ypel3 34
  • 95.24 (n)
oppossum
(Monodelphis domestica)
Mammalia YPEL3 35
  • 90 (a)
OneToOne
African clawed frog
(Xenopus laevis)
Amphibia Xl.9405 34
zebrafish
(Danio rerio)
Actinopterygii ypel3 35
  • 90 (a)
OneToMany
LOC561851 34
  • 78.43 (n)
fruit fly
(Drosophila melanogaster)
Insecta CG15309 35
  • 82 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea F37A8.5 34 35
  • 70.47 (n)
A. gosspyii yeast
(Ashbya gossypii)
Saccharomycetes AGOS_ABR153C 34
  • 54.68 (n)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes MOH1 34 35
  • 51.77 (n)
K. lactis yeast
(Kluyveromyces lactis)
Saccharomycetes KLLA0E05875g 34
  • 49.07 (n)
thale cress
(Arabidopsis thaliana)
eudicotyledons AT3G11230 34
  • 58.89 (n)
barley
(Hordeum vulgare)
Liliopsida Hv.6839 34
sea squirt
(Ciona savignyi)
Ascidiacea -- 35
  • 79 (a)
OneToMany
bread mold
(Neurospora crassa)
Ascomycetes NCU00024 34
  • 60.54 (n)
fission yeast
(Schizosaccharomyces pombe)
Schizosaccharomycetes SPAPJ691.02 34
  • 47.1 (n)
Species where no ortholog for YPEL3 was found in the sources mined by GeneCards:
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • beta proteobacteria (Neisseria meningitidis)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)

Evolution for YPEL3 Gene

ENSEMBL:
Gene Tree for YPEL3 (if available)
TreeFam:
Gene Tree for YPEL3 (if available)

Paralogs for YPEL3 Gene

Paralogs for YPEL3 Gene

(4) SIMAP similar genes for YPEL3 Gene using alignment to 5 proteins:

genes like me logo Genes that share paralogs with YPEL3: view

Variants for YPEL3 Gene

Sequence variations from dbSNP and Humsavar for YPEL3 Gene

SNP ID Clin Chr 16 pos Sequence Context AA Info Type
rs1044572 -- 30,092,440(-) GTGTT(C/T)TGCTC nc-transcript-variant, upstream-variant-2KB, utr-variant-3-prime
rs1044584 -- 30,092,414(-) ACCGT(C/T)TGCTC nc-transcript-variant, upstream-variant-2KB, utr-variant-3-prime
rs1044634 -- 30,092,353(-) TCGTT(C/T)TGTAG nc-transcript-variant, upstream-variant-2KB, utr-variant-3-prime
rs112305247 -- 30,091,959(+) AGGCT(C/G)AGCGC downstream-variant-500B, upstream-variant-2KB
rs113020474 -- 30,092,800(+) TGTTC(A/C)TGAAA upstream-variant-2KB, splice-acceptor-variant

Structural Variations from Database of Genomic Variants (DGV) for YPEL3 Gene

Variant ID Type Subtype PubMed ID
esv2758642 CNV gain 17122850
nsv1160384 CNV duplication 26073780
nsv833187 CNV loss 17160897

Variation tolerance for YPEL3 Gene

Residual Variation Intolerance Score: 46.5% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.85; 17.75% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for YPEL3 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
YPEL3

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for YPEL3 Gene

Disorders for YPEL3 Gene

Relevant External Links for YPEL3

Genetic Association Database (GAD)
YPEL3
Human Genome Epidemiology (HuGE) Navigator
YPEL3
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
YPEL3

No disorders were found for YPEL3 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for YPEL3 Gene

Publications for YPEL3 Gene

  1. Identification and characterization of a novel gene family YPEL in a wide spectrum of eukaryotic species. (PMID: 15556292) Hosono K. … Shimizu N. (Gene 2004) 2 3 4 64
  2. Centrosome-related genes, genetic variation, and risk of breast cancer. (PMID: 20508983) Olson J.E. … Couch F.J. (Breast Cancer Res. Treat. 2011) 3 46 64
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4 64
  4. Phospho-tyrosine dependent protein-protein interaction network. (PMID: 25814554) Grossmann A. … Stelzl U. (Mol. Syst. Biol. 2015) 3 64
  5. Biological insights from 108 schizophrenia-associated genetic loci. (PMID: 25056061) (Nature 2014) 3 64

Products for YPEL3 Gene

Sources for YPEL3 Gene

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