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Aliases for YPEL3 Gene

Aliases for YPEL3 Gene

  • Yippee Like 3 2 3 5
  • Yippee-Like 3 (Drosophila) 2

External Ids for YPEL3 Gene

Previous GeneCards Identifiers for YPEL3 Gene

  • GC16M030011
  • GC16M027764

Summaries for YPEL3 Gene

GeneCards Summary for YPEL3 Gene

YPEL3 (Yippee Like 3) is a Protein Coding gene. An important paralog of this gene is YPEL2.

UniProtKB/Swiss-Prot for YPEL3 Gene

  • Involved in proliferation and apoptosis in myeloid precursor cells.

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for YPEL3 Gene

Genomics for YPEL3 Gene

Regulatory Elements for YPEL3 Gene

Promoters for YPEL3 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around YPEL3 on UCSC Golden Path with GeneCards custom track

Transcription factor binding sites by QIAGEN in the YPEL3 gene promoter:

Genomic Location for YPEL3 Gene

Chromosome:
16
Start:
30,092,314 bp from pter
End:
30,096,915 bp from pter
Size:
4,602 bases
Orientation:
Minus strand

Genomic View for YPEL3 Gene

Genes around YPEL3 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
YPEL3 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for YPEL3 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for YPEL3 Gene

Proteins for YPEL3 Gene

  • Protein details for YPEL3 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P61236-YPEL3_HUMAN
    Recommended name:
    Protein yippee-like 3
    Protein Accession:
    P61236
    Secondary Accessions:
    • Q65Z99
    • Q86VK6
    • Q9BSJ4
    • Q9CQB6

    Protein attributes for YPEL3 Gene

    Size:
    119 amino acids
    Molecular mass:
    13608 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=EAW79925.1; Type=Erroneous initiation; Evidence={ECO:0000305};

    Alternative splice isoforms for YPEL3 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for YPEL3 Gene

Proteomics data for YPEL3 Gene at MOPED

Post-translational modifications for YPEL3 Gene

Antibody Products

No data available for DME Specific Peptides for YPEL3 Gene

Domains & Families for YPEL3 Gene

Gene Families for YPEL3 Gene

Protein Domains for YPEL3 Gene

InterPro:
Blocks:
ProtoNet:

Suggested Antigen Peptide Sequences for YPEL3 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

P61236

UniProtKB/Swiss-Prot:

YPEL3_HUMAN :
  • Contains 1 Yippee domain.
  • Belongs to the yippee family.
Domain:
  • Contains 1 Yippee domain.
Family:
  • Belongs to the yippee family.
genes like me logo Genes that share domains with YPEL3: view

Function for YPEL3 Gene

Molecular function for YPEL3 Gene

UniProtKB/Swiss-Prot Function:
Involved in proliferation and apoptosis in myeloid precursor cells.

Phenotypes for YPEL3 Gene

genes like me logo Genes that share phenotypes with YPEL3: view

Animal Models for YPEL3 Gene

MGI Knock Outs for YPEL3:

Animal Model Products

miRNA for YPEL3 Gene

miRTarBase miRNAs that target YPEL3

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for YPEL3 Gene

Localization for YPEL3 Gene

Subcellular locations from UniProtKB/Swiss-Prot for YPEL3 Gene

Nucleus, nucleolus.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for YPEL3 Gene COMPARTMENTS Subcellular localization image for YPEL3 gene
Compartment Confidence
nucleus 3
extracellular 2
mitochondrion 2
cytosol 1

No data available for Gene Ontology (GO) - Cellular Components for YPEL3 Gene

Pathways & Interactions for YPEL3 Gene

SuperPathways for YPEL3 Gene

No Data Available

Interacting Proteins for YPEL3 Gene

Gene Ontology (GO) - Biological Process for YPEL3 Gene

None

No data available for Pathways by source and SIGNOR curated interactions for YPEL3 Gene

Drugs & Compounds for YPEL3 Gene

No Compound Related Data Available

Transcripts for YPEL3 Gene

Unigene Clusters for YPEL3 Gene

Yippee-like 3 (Drosophila):
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for YPEL3 Gene

ExUns: 1 ^ 2a · 2b ^ 3a · 3b · 3c · 3d ^ 4a · 4b · 4c ^ 5a · 5b · 5c ^ 6a · 6b · 6c
SP1: - - - - - - -
SP2: - - - - -
SP3: - - -
SP4: - - - - -
SP5: - - -
SP6: - -
SP7:

Relevant External Links for YPEL3 Gene

GeneLoc Exon Structure for
YPEL3
ECgene alternative splicing isoforms for
YPEL3

Expression for YPEL3 Gene

mRNA expression in normal human tissues for YPEL3 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for YPEL3 Gene

This gene is overexpressed in Whole Blood (x8.6).

Protein differential expression in normal tissues from HIPED for YPEL3 Gene

This gene is overexpressed in Platelet (44.9) and Heart (24.1).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for YPEL3 Gene



SOURCE GeneReport for Unigene cluster for YPEL3 Gene Hs.513491

mRNA Expression by UniProt/SwissProt for YPEL3 Gene

P61236-YPEL3_HUMAN
Tissue specificity: Widely expressed.
genes like me logo Genes that share expression patterns with YPEL3: view

Protein tissue co-expression partners for YPEL3 Gene

Primer Products

In Situ Assay Products

Orthologs for YPEL3 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for YPEL3 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia YPEL3 35
  • 99.44 (n)
  • 98.32 (a)
YPEL3 36
  • 98 (a)
OneToOne
cow
(Bos Taurus)
Mammalia YPEL3 36
  • 100 (a)
OneToOne
YPEL3 35
  • 97.48 (n)
  • 100 (a)
dog
(Canis familiaris)
Mammalia YPEL3 35
  • 98.04 (n)
  • 100 (a)
YPEL3 36
  • 100 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Ypel3 35
  • 95.52 (n)
  • 100 (a)
Ypel3 16
Ypel3 36
  • 100 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia YPEL3 36
  • 90 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Ypel3 35
  • 95.24 (n)
  • 100 (a)
African clawed frog
(Xenopus laevis)
Amphibia Xl.9405 35
zebrafish
(Danio rerio)
Actinopterygii LOC561851 35
  • 78.43 (n)
  • 88.24 (a)
ypel3 36
  • 90 (a)
OneToMany
fruit fly
(Drosophila melanogaster)
Insecta CG15309 36
  • 82 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea F37A8.5 36
  • 71 (a)
OneToMany
F37A8.5 35
  • 70.47 (n)
  • 82.46 (a)
A. gosspyii yeast
(Ashbya gossypii)
Saccharomycetes AGOS_ABR153C 35
  • 54.68 (n)
  • 46.07 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes MOH1 35
  • 51.77 (n)
  • 47.87 (a)
MOH1 36
  • 35 (a)
OneToMany
K. lactis yeast
(Kluyveromyces lactis)
Saccharomycetes KLLA0E05875g 35
  • 49.07 (n)
  • 45.37 (a)
thale cress
(Arabidopsis thaliana)
eudicotyledons AT3G11230 35
  • 58.89 (n)
  • 55.56 (a)
barley
(Hordeum vulgare)
Liliopsida Hv.6839 35
bread mold
(Neurospora crassa)
Ascomycetes NCU00024 35
  • 60.54 (n)
  • 54.08 (a)
fission yeast
(Schizosaccharomyces pombe)
Schizosaccharomycetes SPAPJ691.02 35
  • 47.1 (n)
  • 42.39 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 79 (a)
OneToMany
Species with no ortholog for YPEL3:
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • beta proteobacteria (Neisseria meningitidis)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)

Evolution for YPEL3 Gene

ENSEMBL:
Gene Tree for YPEL3 (if available)
TreeFam:
Gene Tree for YPEL3 (if available)

Paralogs for YPEL3 Gene

Paralogs for YPEL3 Gene

(4) SIMAP similar genes for YPEL3 Gene using alignment to 5 proteins:

genes like me logo Genes that share paralogs with YPEL3: view

Variants for YPEL3 Gene

Sequence variations from dbSNP and Humsavar for YPEL3 Gene

SNP ID Clin Chr 16 pos Sequence Context AA Info Type
rs528470477 -- 30,094,109(+) CTGAT(A/C)CCTGT intron-variant, nc-transcript-variant
rs540308817 -- 30,094,160(+) AGAGA(G/T)AAGGA intron-variant
rs561072554 -- 30,094,059(+) AGAAT(C/T)CTGTC intron-variant, nc-transcript-variant
rs765098209 -- 30,093,994(+) TGGCT(A/G)GCTGG intron-variant, nc-transcript-variant
rs750969751 -- 30,094,302(+) GACAA(C/T)ATAAG intron-variant

Structural Variations from Database of Genomic Variants (DGV) for YPEL3 Gene

Variant ID Type Subtype PubMed ID
dgv2668n71 CNV Loss 21882294
nsv833187 CNV Loss 17160897
nsv905720 CNV Loss 21882294
dgv846e1 CNV Complex 17122850

Variation tolerance for YPEL3 Gene

Residual Variation Intolerance Score: 46.5% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.85; 17.75% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for YPEL3 Gene

HapMap Linkage Disequilibrium report
YPEL3

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for YPEL3 Gene

Disorders for YPEL3 Gene

Relevant External Links for YPEL3

Genetic Association Database (GAD)
YPEL3
Human Genome Epidemiology (HuGE) Navigator
YPEL3
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
YPEL3

No disorders were found for YPEL3 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for YPEL3 Gene

Publications for YPEL3 Gene

  1. Identification and characterization of a novel gene family YPEL in a wide spectrum of eukaryotic species. (PMID: 15556292) Hosono K. … Shimizu N. (Gene 2004) 2 3 4 67
  2. Phospho-tyrosine dependent protein-protein interaction network. (PMID: 25814554) Grossmann A. … Stelzl U. (Mol. Syst. Biol. 2015) 3
  3. Biological insights from 108 schizophrenia-associated genetic loci. (PMID: 25056061) (Nature 2014) 3
  4. A proteome-scale map of the human interactome network. (PMID: 25416956) Rolland T. … Vidal M. (Cell 2014) 3
  5. The protein interaction landscape of the human CMGC kinase group. (PMID: 23602568) Varjosalo M. … Gstaiger M. (Cell Rep 2013) 3

Products for YPEL3 Gene

Sources for YPEL3 Gene

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