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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

YPEL3 Gene

protein-coding   GIFtS: 46
GCID: GC16M030103

Yippee-Like 3 (Drosophila)

  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Yippee-Like 3 (Drosophila)1 2
Protein Yippee-Like 32

External Ids:    HGNC: 183271   Entrez Gene: 837192   Ensembl: ENSG000000902387   OMIM: 6097245   UniProtKB: P612363   

Export aliases for YPEL3 gene to outside databases

Previous GC identifers: GC16M030011 GC16M027764


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

GeneCards Summary for YPEL3 Gene: 
YPEL3 (yippee-like 3 (Drosophila)) is a protein-coding gene. Diseases associated with YPEL3 include estrogen-receptor positive breast cancer, and digeorge syndrome. An important paralog of this gene is YPEL1.

UniProtKB/Swiss-Prot: YPEL3_HUMAN, P61236
Function: Involved in proliferation and apoptosis in myeloid precursor cells (By similarity)




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000016.9  NT_010393.16  NC_018927.2  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the YPEL3 gene promoter:
         c-Fos   AP-1   c-Jun   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidYPEL3 promoter sequence
   Search SABiosciences Chromatin IP Primers for YPEL3

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat YPEL3


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 16p11.2   Ensembl cytogenetic band:  16p11.2   HGNC cytogenetic band: 16p11

YPEL3 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
YPEL3 gene location

GeneLoc information about chromosome 16         GeneLoc Exon Structure

GeneLoc location for GC16M030103:  view genomic region     (about GC identifiers)

Start:
30,103,635 bp from pter      End:
30,108,236 bp from pter
Size:
4,602 bases      Orientation:
minus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: YPEL3_HUMAN, P61236 (See protein sequence)
Recommended Name: Protein yippee-like 3  
Size: 119 amino acids; 13608 Da
Subcellular location: Nucleus, nucleolus
Sequence caution: Sequence=EAW79925.1; Type=Erroneous initiation;
Secondary accessions: Q65Z99 Q86VK6 Q9BSJ4 Q9CQB6
Alternative splicing: 2 isoforms:  P61236-1   P61236-2   

Explore the universe of human proteins at neXtProt for YPEL3: NX_P61236

Explore proteomics data for YPEL3 at MOPED 

Post-translational modifications:

  • UniProtKB: Probably ubiquitinated leading to its degradation by the proteasome (By similarity)
  • View neXtProt modification sites for NX_P61236

  • YPEL3 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    YPEL3 Protein Expression
    REFSEQ proteins (2 alternative transcripts): 
    NP_001138996.1  NP_113665.3  

    ENSEMBL proteins: 
     ENSP00000454949   ENSP00000381821   ENSP00000457598   ENSP00000381818   ENSP00000457976  
     ENSP00000456427   ENSP00000454350   ENSP00000456825   ENSP00000456212  

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    Cloud-Clone Corp. Proteins for YPEL3 

    Gene Ontology (GO): 1 cellular component term (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005730nucleolus IEA--

    YPEL3 for ontologies           About GeneDecksing



    YPEL3 Antibody Products: 
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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    1 InterPro protein domain:
     IPR004910 Yippee

    Graphical View of Domain Structure for InterPro Entry P61236

    ProtoNet protein and cluster: P61236

    1 Blocks protein domain: IPB004910 Yippee-like protein

    UniProtKB/Swiss-Prot: YPEL3_HUMAN, P61236
    Similarity: Belongs to the yippee family


    YPEL3 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: YPEL3_HUMAN, P61236
    Function: Involved in proliferation and apoptosis in myeloid precursor cells (By similarity)

    Animal Models:

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    SwitchGear 3'UTR luciferase reporter plasmidYPEL3 3' UTR sequence
    Inhib. RNA
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    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section



    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for YPEL3

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for YPEL3

    Search CenterWatch for drugs/clinical trials and news about YPEL3

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for YPEL3 gene (2 alternative transcripts): 
    NM_001145524.1  NM_031477.4  

    Unigene Cluster for YPEL3:

    Yippee-like 3 (Drosophila)
    Hs.513491  [show with all ESTs]
    Unigene Representative Sequence: AK022409
    12 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000570099 ENST00000398841(uc002dwl.3 uc002dwm.3) ENST00000565479
    ENST00000566134 ENST00000398838 ENST00000563788 ENST00000566595 ENST00000565110
    ENST00000568674 ENST00000568681 ENST00000562641(uc002dwn.1) ENST00000566401

    miRNA
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    8/10 QIAGEN miScript miRNA Assays for microRNAs that regulate YPEL3 (see all 10):
    hsa-miR-3163 hsa-miR-3194-5p hsa-miR-148b hsa-miR-27a hsa-miR-548v hsa-miR-128 hsa-miR-3681* hsa-miR-152
    SwitchGear 3'UTR luciferase reporter plasmidYPEL3 3' UTR sequence
    Inhib. RNA
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      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat YPEL3
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    Additional mRNA sequence: 

    AB098737.1 AF305622.1 AK022409.1 AK026047.1 AL359610.1 BC005009.1 BC050664.1 

    15 DOTS entries:

    DT.452139  DT.100024056  DT.97842587  DT.97842588  DT.91762394  DT.95272609  DT.120695071  DT.120695860 
    DT.95107770  DT.95272610  DT.120695432  DT.121636264  DT.40118507  DT.91748024  DT.100696780 

    24/162 AceView cDNA sequences (see all 162):

    BX351623 CR598881 AW161040 F29204 AI304823 AI318383 CR606841 BQ787397 
    AW072082 BU070387 AI568781 AI804817 CR604822 BM762254 BX480343 BM709084 
    BQ710636 CB306825 AI348611 AI865104 BQ185491 AI318382 AA830980 AA342171 

    GeneLoc Exon Structure

    5/7 Alternative Splicing Database (ASD) splice patterns (SP) for YPEL3 (see all 7)    About this scheme

    ExUns: 1 ^ 2a · 2b ^ 3a · 3b · 3c · 3d ^ 4a · 4b · 4c ^ 5a · 5b · 5c ^ 6a · 6b · 6c
    SP1:        -     -     -     -                       -     -                 -                     
    SP2:                    -     -                       -     -                 -                     
    SP3:                    -     -                             -                                       
    SP4:                    -     -     -                 -     -                                       
    SP5:                                                  -     -                 -                     


    ECgene alternative splicing isoforms for YPEL3

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    YPEL3 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: CACTGTGACC
    YPEL3 Expression
    About this image


    See YPEL3 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for YPEL3

    SOURCE GeneReport for Unigene cluster: Hs.513491

    UniProtKB/Swiss-Prot: YPEL3_HUMAN, P61236
    Tissue specificity: Widely expressed

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    In Situ
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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of eukaryotes.

    Orthologs for YPEL3 gene from 8/16 species (see all 16)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Ypel31 , 5 yippee-like 3 (Drosophila)1, 5 95.52(n)1
    100(a)1
      7 (69.25 cM)5
    660901  NM_025347.21  NP_079623.11 
     1267769555 
    African clawed frog
    (Xenopus laevis)
    Amphibia Xl.94052 Xenopus laevis transcribed sequence with strong similarity more 87.17(n)    BG347776.1 
    zebrafish
    (Danio rerio)
    Actinopterygii LOC1000047271 protein yippee-like 1-like 77.04(n)
    82.22(a)
      100004727  XM_001343922.3  XP_001343958.3 
    fruit fly
    (Drosophila melanogaster)
    Insecta CG153096
    --
    81(a)
    1 → many
    X(10099325-10106407)
    worm
    (Caenorhabditis elegans)
    Secernentea F37A8.56
    Protein yippee-like F37A8.5
    70(a)
    1 → many
    III(3956624-3957475)
    baker's yeast
    (Saccharomyces cerevisiae)
    Saccharomycetes MOH16
    Protein of unknown function, has homology to kinas...
    33(a)
    1 → many
    II(126828-127244)
    thale cress
    (Arabidopsis thaliana)
    eudicotyledons AT4G277451 yippee-like protein 59.52(n)
    58.16(a)
      3770406  NM_001036656.4  NP_001031733.1 
    rice
    (Oryza sativa)
    Liliopsida Os11g05518001 hypothetical protein 61.56(n)
    60.2(a)
      4350710  NM_001074612.1  NP_001068080.1 


    ENSEMBL Gene Tree for YPEL3 (if available)
    TreeFam Gene Tree for YPEL3 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for YPEL3 gene
    YPEL12  YPEL22  YPEL42  YPEL52  
    4 SIMAP similar genes for YPEL3 using alignment to 5 protein entries:     YPEL3_HUMAN (see all proteins):
    YPEL2    YPEL4    YPEL1    YPEL5

    YPEL3 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/65 SNPs in YPEL3 are shown (see all 65)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 16 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1397784071,2
    --27770733(+) TCCCCA/CACATA 1 -- int10--------
    rs1406493031,2
    --30105214(+) GGCCAC/GCTCTT 2 -- int10--------
    rs1907992601,2
    --30105376(+) CTGAAA/GAATCC 2 -- int10--------
    rs794800621,2
    --30105715(+) TGGGTG/TATCTT 2 -- int10--------
    rs1833949161,2
    --30105880(+) TGATTA/GTATCC 2 -- int10--------
    rs1471121831,2
    C--30105889(+) CCTAAC/TTCTCT 2 -- int10--------
    rs782540811,2
    F--30105920(+) GGAGAG/CAAGGG 2 -- int11Minor allele frequency- C:0.05WA 118
    rs2009701191,2
    C,F--30106134(+) GTCTTG/ACAGTT 4 /C syn11Minor allele frequency- A:0.00EU 1323
    rs1385016031,2
    C--30106221(+) ACCCTA/C/GTGGGG 2 -- int10--------
    rs1878071941,2
    C--30106247(+) AGGGAC/GGGTCC 2 -- int10--------

    HapMap Linkage Disequilibrium report for YPEL3 (30103635 - 30108236 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 4 variations for YPEL3:    About this table     
    Variant IDTypeSubtypePubMed ID
    nsv833187CNV Loss17160897
    dgv2668n71CNV Loss21882294
    nsv905720CNV Loss21882294
    dgv846e1CNV Complex17122850

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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 609724    OMIM disorders: --

    4 diseases for YPEL3:    About MalaCards
    estrogen-receptor positive breast cancer    digeorge syndrome    cellulitis    breast cancer

    1 disease from the University of Copenhagen DISEASES database for YPEL3:
    estrogen-receptor positive breast cancer

    YPEL3 for disorders           About GeneDecksing

    Genetic Association Database (GAD): YPEL3
    Human Genome Epidemiology (HuGE) Navigator: YPEL3 (1 document)

    Export disorders for YPEL3 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for YPEL3 gene, integrated from 9 sources (see all 11):
    (articles sorted by number of sources associating them with YPEL3)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Centrosome-related genes, genetic variation, and risk of breast cancer. (PubMed id 20508983)1, 4 Olson J.E....Couch F.J. (2010)
    2. Identification and characterization of a novel gene family YPEL in a wide spectrum of eukaryotic species. (PubMed id 15556292)1, 2 Hosono K.... Shimizu N. (2004)
    3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    4. Novel senescence associated gene, YPEL3, is repressed by estrogen in ER+ mammary tumor cells and required for tamoxifen-induced cellul ar senescence. (PubMed id 21671470)1 Tuttle R....Berberich S.J. (2012)
    5. Senescence-associated gene YPEL3 is downregulated in human colon tumors. (PubMed id 21267786)1 Tuttle R....Berberich S.J. (2011)
    6. Why YPEL3 represents a novel tumor suppressor. (PubMed id 21196260)1 Berberich S.J....Tuttle R. (2011)
    7. Interactions of pathological hallmark proteins: tubul in polymerization promoting protein/p25, beta-amyloid, and alpha-synuclein. (PubMed id 21832049)1 OlA!h J....OvA!di J. (2011)
    8. YPEL3, a p53-regulated gene that induces cellular sen escence. (PubMed id 20388804)1 Kelley K.D....Berberich S.J. (2010)
    9. The sequence and analysis of duplication-rich human chromosome 16. (PubMed id 15616553)2 Martin J.... Pennacchio L.A. (2004)
    10. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1 Ota T.... Sugano S. (2004)

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    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 83719 HGNC: 18327 AceView: YPEL3 Ensembl:ENSG00000090238 euGenes: HUgn83719
    ECgene: YPEL3 H-InvDB: YPEL3

    (According to HUGE)
    About This Section
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    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for YPEL3 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for YPEL3 gene:
    Search GeneIP for patents involving YPEL3

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