YPEL3 Gene
protein-coding GIFtS: 45
GCID: GC16M030103
|
|
yippee-like 3 (Drosophila)
| |
Aliases
for YPEL3 gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| Yippee-Like 3 (Drosophila)1 2 | | MGC105001 | | Protein Yippee-Like 32 |
Export aliases for YPEL3 gene to outside databasesPrevious GC identifers: GC16M030011 GC16M027764 |
Summaries
for YPEL3 gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
UniProtKB/Swiss-Prot: YPEL3_HUMAN, P61236Function: Involved in proliferation and apoptosis in myeloid precursor cells (By similarity)
|
Genomic Views
for YPEL3 gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000016.9 NC_018927.1 NT_010393.16
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the YPEL3 gene promoter:
c-Fos AP-1 c-Jun
Other transcription factors
Search SABiosciences Chromatin IP Primers for YPEL3
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat YPEL3 |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 16p11.2 Ensembl cytogenetic band: 16p11.2 HGNC cytogenetic band: 16p11YPEL3 Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 16 GeneLoc Exon Structure GeneLoc location for GC16M030103: view genomic region
(about GC identifiers)
Start:
|
30,103,635 bp from pter |
End:
|
30,108,236 bp from pter |
Size:
|
4,602 bases |
Orientation:
|
minus strand |
|
Proteins
for YPEL3 gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: YPEL3_HUMAN, P61236 (See
protein sequence)Recommended Name: Protein yippee-like 3 Size: 119 amino acids; 13608 Da
Subcellular location: Nucleus, nucleolus
Sequence caution: Sequence=EAW79925.1; Type=Erroneous initiation;
Secondary accessions: Q65Z99 Q86VK6 Q9BSJ4 Q9CQB6Alternative splicing: 2 isoforms: P61236-1 P61236-2 Explore the universe of human proteins at neXtProt for YPEL3: NX_P61236
Post-translational modifications:
Probably ubiquitinated leading to its degradation by the proteasome (By similarity)1
View neXtProt modification sites for NX_P61236
YPEL3 Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins (2 alternative transcripts):
NP_001138996.1 NP_113665.3
ENSEMBL proteins: ENSP00000454949 ENSP00000381821 ENSP00000457598 ENSP00000381818 ENSP00000457976 ENSP00000456427 ENSP00000454350 ENSP00000456825 ENSP00000456212
Human Recombinant Protein Products:
Gene Ontology (GO): 1 cellular component term (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0005730 | nucleolus |
IEA | -- |
YPEL3 for ontologies About GeneDecksing
YPEL3 Antibody Products:
Assay Products for YPEL3: |
Protein
Domains /
Families
for YPEL3 gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
YPEL3 for domains About GeneDecksing
1 InterPro domain/family:Graphical View of Domain Structure for InterPro Entry P61236ProtoNet protein and cluster: P61236 1 Blocks protein family: IPB004910 Yippee-like protein
UniProtKB/Swiss-Prot: YPEL3_HUMAN, P61236Similarity: Belongs to the yippee family |
Function
for YPEL3 gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Function Summary:
UniProtKB/Swiss-Prot: YPEL3_HUMAN, P61236Function: Involved in proliferation and apoptosis in myeloid precursor cells (By similarity)
Clone
Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for YPEL3 (see all 4)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for YPEL3 (see all 3)
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
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In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for YPEL3 |
|
Pathways & Interactions
for YPEL3 gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Interactions:
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for YPEL3
|
Drugs & Compounds
for YPEL3 gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
 Browse Tocris compounds for YPEL3
Search CenterWatch for drugs/clinical trials and news about YPEL3
|
Transcripts
for YPEL3 gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for YPEL3 gene (2 alternative transcripts): NM_001145524.1 NM_031477.4 Unigene Cluster for YPEL3: Yippee-like 3 (Drosophila) Hs.513491 [show with all ESTs]Unigene Representative Sequence: AK02240912 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000570099 ENST00000398841(uc002dwl.3 uc002dwm.3) ENST00000565479
ENST00000566134 ENST00000398838 ENST00000563788 ENST00000566595 ENST00000565110
ENST00000568674 ENST00000568681 ENST00000562641(uc002dwn.1) ENST00000566401
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for YPEL3 (see all 4)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for YPEL3 (see all 3)
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector (see all 2): YPEL3 (NM_031477) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for YPEL3 | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat YPEL3 |
Additional cDNA sequence: AB098737.1 AF305622.1 AK022409.1 AK026047.1 AL359610.1 BC005009.1 BC050664.1 15 DOTS entries: DT.452139 DT.100024056 DT.97842587 DT.97842588 DT.91762394 DT.95272609 DT.120695071 DT.120695860 DT.95107770 DT.95272610 DT.120695432 DT.121636264 DT.40118507 DT.91748024 DT.100696780 24/162 AceView cDNA sequences (see all 162): AI348611 CR598881 BC005009 AW161040 BU732551 BQ787397 BQ710636 AW072082 AA830980 AI318382 AK026047 BM690281 BU608102 AI184354 CR604822 BM762254 BX480343 BM709084 AI804817 AA933695 AI304823 AI865104 CR606841 BQ185491
GeneLoc Exon Structure
5/7 Alternative Splicing Database (ASD) splice patterns (SP) for YPEL3 (see all 7) About this scheme
| ExUns: | 1 | ^ | 2a | · | 2b | ^ | 3a | · | 3b | · | 3c | · | 3d | ^ | 4a | · | 4b | · | 4c | ^ | 5a | · | 5b | · | 5c | ^ | 6a | · | 6b | · | 6c |
|---|
|
| SP1: | | | - | | - | | - | | - | | | | | | | | - | | - | | | | | | - | | | | | | | | |
| SP2: | | | | | | | - | | - | | | | | | | | - | | - | | | | | | - | | | | | | | | |
| SP3: | | | | | | | - | | - | | | | | | | | | | - | | | | | | | | | | | | | | |
| SP4: | | | | | | | - | | - | | - | | | | | | - | | - | | | | | | | | | | | | | | |
| SP5: | | | | | | | | | | | | | | | | | - | | - | | | | | | - | | | | | | | |
ECgene alternative splicing isoforms for YPEL3
|
Expression
for YPEL3 gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| YPEL3 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: CACTGTGACC
About this image
See YPEL3 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for YPEL3
SOURCE GeneReport for Unigene cluster: Hs.513491
UniProtKB/Swiss-Prot: YPEL3_HUMAN, P61236Tissue specificity: Widely expressed
SABiosciences Custom PCR Arrays for YPEL3
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for YPEL3
Browse OriGene validated miRNA SYBR primer pairs
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse, rat YPEL3 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat YPEL3 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat YPEL3 | In Situ
Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for YPEL3 |
Orthologs
for YPEL3 gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of eukaryotes.
Orthologs for YPEL3 gene from 7/22 species (see all 22) About this table
ENSEMBL Gene Tree for YPEL3 (if available)
TreeFam Gene Tree for YPEL3 (if available) |
Paralogs
for YPEL3 gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| Paralogs for YPEL3 gene
- YPEL12 YPEL22 YPEL42 YPEL52
4 SIMAP similar genes for YPEL3 using alignment to 5 protein entries: YPEL3_HUMAN (see all proteins):YPEL2 YPEL4 YPEL1 YPEL5
YPEL3 for paralogs About GeneDecksing
|
Genomic Variants
for YPEL3 gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 16 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for YPEL3 (30103635 - 30108236 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 3 variations for YPEL3
3 CNVs: 4940 35383 4001 | SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing YPEL3 |
|
Disorders
/ Diseases
for YPEL3 gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
YPEL3 for disorders About GeneDecksing
OMIM gene information: 609724
OMIM disorders: --
4  diseases for YPEL3: About MalaCardsestrogen-receptor positive breast cancer digeorge syndrome breast cancer malaria
1 disease from the University of Copenhagen DISEASES database for YPEL3:estrogen-receptor positive breast cancer Human Genome Epidemiology (HuGE) Navigator: YPEL3 (1 document)
Export disorders for YPEL3 gene to outside databases
|
Publications
for YPEL3 gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for YPEL3 gene, integrated from 9 sources (see all 11):
(articles sorted by number of sources associating them with YPEL3) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- Identification and characterization of a novel gene family YPEL in a wide spectrum of eukaryotic species. (PubMed id 15556292)1, 2 Hosono K.... Shimizu N. (2004)
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
- Novel senescence associated gene, YPEL3, is repressed by estrogen in ER+ mammary tumor cells and required for tamoxifen-induced cellul ar senescence. (PubMed id 21671470)1 Tuttle R....Berberich S.J. (2012)
- Senescence-associated gene YPEL3 is downregulated in human colon tumors. (PubMed id 21267786)1 Tuttle R....Berberich S.J. (2011)
- Why YPEL3 represents a novel tumor suppressor. (PubMed id 21196260)1 Berberich S.J....Tuttle R. (2011)
- Interactions of pathological hallmark proteins: tubul in polymerization promoting protein/p25, beta-amyloid, and alpha-synuclein. (PubMed id 21832049)1 OlA!h J....OvA!di J. (2011)
- YPEL3, a p53-regulated gene that induces cellular sen escence. (PubMed id 20388804)1 Kelley K.D....Berberich S.J. (2010)
- Centrosome-related genes, genetic variation, and risk of breast cancer. (PubMed id 20508983)1 Olson J.E....Couch F.J. (2010)
- The sequence and analysis of duplication-rich human chromosome 16. (PubMed id 15616553)2 Martin J.... Pennacchio L.A. (2004)
- Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1 Ota T.... Sugano S. (2004)
|
External Searches for YPEL3 gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
|
Genome Databases showing YPEL3 gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing YPEL3 gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing YPEL3 gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
| Name | Description |
| PharmGKB entry for YPEL3 | Pharmacogenomics, SNPs, Pathways |
|
| | |
About This Section
| Patent Information for YPEL3 gene:
Search GeneIP for patents involving YPEL3
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for YPEL3 gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
About This Section
|
 | |
 | |
 |
| | |  | Browse OriGene Antibodies | | Browse OriGene shRNA RFPs | | | OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for YPEL3 | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for YPEL3 | | | OriGene Protein Over-expression Lysate for YPEL3 | | Browse OriGene Fluorogenic Cell Assay Kits | | | OriGene siRNA for YPEL3 | | OriGene 3'-UTR Clone for YPEL3 | | | OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for YPEL3 | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for YPEL3 | | | Browse OriGene GFP tagged cDNA clones in CMV expression vector | | Browse OriGene MicroRNA Expression Plasmids | | | Browse OriGene basic RS shRNAs | | Browse OriGene validated miRNA SYBR primer pairs | | | Browse OriGene full length recombinant human proteins expressed in human HEK293 cells | | OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
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| | | QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat YPEL3 | | | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing YPEL3 | | | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat YPEL3 | | | QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat YPEL3 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat YPEL3 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat YPEL3 |
| |
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 | | | YPEL3 Proteins, Antibodies, CLIAs, and ELISAs |
| | | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for YPEL3 |
|  |  |  | | | | Search ThermoFisher Antibodies for YPEL3 |
| | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat YPEL3 |
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