V3 here soon-try beta now


Gene Search (GeneCards Home)	\|	GeneCards Guide	\|	User Feedback	\|	Terms of Use	\|	Notice about third-party sites

YPEL3 Gene

protein-coding GIFtS: 46

GC16M030011

yippee-like 3 (Drosophila)
Symbol approved by the HUGO Gene Nomenclature Committee (HGNC) database

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc , and/or ⁷Ensembl, ⁸miRBase)
About This Section

Aliases
MGC10500 ^¹, ²

Descriptions
yippee-like 3 ^²
yippee-like 3 (Drosophila) ^²

External Ids
HGNC: 18327¹
Entrez Gene: 83719²
UniProtKB: P61236³
Ensembl: ENSG00000090238⁷

Search outside databases for aliases for YPEL3 gene

(According to Entrez Gene, Wikipedia's Gene Wiki,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

UniProtKB/Swiss-Prot: YPEL3_HUMAN, P61236

Function: Involved in proliferation and apoptosis in myeloid precursor cells (By similarity)

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 36),
and/or miRBase,
Genomic Views according to UCSC and Ensembl, Transcription factor binding sites according to SABiosciences)
About This Section

Genomic View:

UCSC Golden Path with GeneCards custom track

Transcription factor binding sites upstream to the YPEL3 gene

Entrez Gene cytogenetic band: 16p11.2 Ensembl cytogenetic band: 16p11.2 HGNC cytogenetic band: 16p11

YPEL3 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)

GeneLoc gene densities for chromosome 16 GeneLoc Exon Structure

GeneLoc location for GC16M030011: (about GC identifiers)

Start:	30,011,136 bp from pter
End:	30,015,038 bp from pter
Size:	3,903 bases
Orientation:	minus strand

RefSeq DNA sequence:

NC_000016.8 NT_010393.15

(According to ¹UniProtKB, and/or Ensembl, Phosphorylation sites according to ²Phosphosite, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Enzo Life Sciences, Abnova, OriGene and/or, Abcam,
Biochemical Assays by Invitrogen, Millipore, R&D Systems, Cell Signaling Technology, and/or Enzo Life Sciences, Ontologies according to Gene Ontology Consortium 01 Apr 2009 and Entrez Gene, Antibodies by Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Cell Signaling Technology, Abcam, Abnova, and/or Novus Biologicals)
About This Section

UniProtKB/Swiss-Prot: YPEL3_HUMAN, P61236 (See protein sequence)

Recommended Name: Protein yippee-like 3

Size: 119 amino acids; 13608 Da

Subcellular location: Nucleus, nucleolus

Secondary accessions: Q65Z99 Q86VK6 Q9BSJ4 Q9CQB6

Alternative splicing: 2 isoforms: P61236-1 P61236-2

Post-translational modifications:

Probably ubiquitinated leading to its degradation by the proteasome (By similarity)¹

REFSEQ proteins (2 alternative transcripts):

NP_001138996.1 NP_113665.3

ENSEMBL proteins:

ENSP00000381818 ENSP00000381821 ENSP00000204279

Human Recombinant Proteins

	Browse Drug Discovery Central at Invitrogen for human recombinant proteins
	Browse Purified and Recombinant Proteins at Millipore
	Browse Human Recombinant Proteins at Sigma-Aldrich
	Browse R&D Systems for human recombinant proteins
	Browse recombinant and purified proteins available from Enzo Life Sciences
	Browse Abcam for Recombinant Proteins
	Human Recombinant Proteins from Abnova (YPEL3)

Browse Origene for full length recombinant human proteins expressed in human HEK293 cells

Antibodies for YPEL3:

	Browse Antibodies Central at Invitrogen
	Browse Millipore's Extensive Line of Mono- and Polyclonal Antibodies
	Browse Antibodies at Sigma-Aldrich
	Browse R&D Systems for Antibodies
	Search for antibodies at Abcam and the World's Antibody Gateway (free search engine of over 150 antibody companies)
	Browse Abnova for Monoclonal and Polyclonal Antibodies
	Search Novus for antibodies for YPEL3

Assays for YPEL3:

	Browse Invitrogen for biochemical assays
	Browse Kits and Assays available from Millipore
	Browse R&D Systems for biochemical assays
	Browse biochemical assays available from Enzo Life Sciences

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

Graphical View of Domain Structure for InterPro Entry P61236

ProtoNet protein and cluster: P61236

1 Blocks protein family: IPB004910 Yippee-like protein

UniProtKB/Swiss-Prot: YPEL3_HUMAN, P61236

Similarity: Belongs to the yippee family

(According to MGI Jun 06 2009, UniProtKB, IUBMB,and/or Genatlas,
shRNA from OriGene, Sigma-Aldrich, RNAi from Sigma-Aldrich,
RNAi Products, Clones, and Q-PCR Products from Invitrogen, Millipore, OriGene, and/or Abnova, siRNAs from Applied Biosystems, SYBR primers from OriGene, Cell-based Assays from Millipore, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
About This Section

Inhib. RNA:		Invitrogen RNAi Products for gene knock-down (YPEL3)
		Browse for Gene Knock-down Tools from Millipore
		Browse Abnova for Chimera RNAi Products

OriGene 29mer shRNA kit in GFP-retroviral vectors (see all 2): NM_031477

Applied Biosystems Silencer® siRNAs for YPEL3

Sigma-Aldrich siRNA for YPEL3

Sigma-Aldrich shRNA for YPEL3

Explore Sigma-Aldrich super-pooled esiRNAs

Clones:		Browse Clone Ranger at Invitrogen for clones
		Browse Clones for the Expression of Recombinant Proteins Available from Millipore

OriGene GFP tagged cDNA clones in CMV expression vector (see all 2): NM_001145524
Myc/DDK tagged cDNA clones in CMV expression vector (see all 2): NM_001145524
untagged cDNA clones in CMV expression vector (see all 4): AK022409

Primers:

Browse Quantitative PCR Central at Invitrogen for Q-PCR LUX™ Primers

OriGene genome-wide validated SYBR primer pairs: NM_031477

UniProtKB/Swiss-Prot: YPEL3_HUMAN, P61236

Function: Involved in proliferation and apoptosis in myeloid precursor cells (By similarity)

(Pathways according to Invitrogen (maps by GeneGo), Millipore, Cell Signaling Technology, Sigma-Aldrich, KEGG and/or UniProtKB,
Sets of similar genes according to GeneDecks, Proteins Network according to SABiosciences, Interactions according to ¹UniProtKB, ²MINT, and/or ³STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
About This Section

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, Sigma-Aldrich, Tocris Bioscience, and/or Novoseek and Drugs according to Enzo Life Sciences and/or PharmGKB)
About This Section

Browse drugs & compounds from Enzo Life Sciences

Browse Small Molecules at Sigma-Aldrich

Browse Tocris compounds for YPEL3

(GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 219 Homo sapiens; Jun 2 2009) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView,
non coding RNAs according to RNAdb,
ESTs according to GeneTide,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from Invitrogen, Millipore, and/or Abnova,
siRNAs from Applied Biosystems, Sigma-Aldrich,
shRNA from Sigma-Aldrich, OriGene,
Tagged/untagged cDNA clones from OriGene,
Expression Assays from Applied Biosystems)
About This Section

Inhib. RNA:		Invitrogen RNAi Products for gene knock-down (YPEL3)
		Browse for Gene Knock-down Tools from Millipore
		Browse Abnova for Chimera RNAi Products

OriGene 29mer shRNA kit in GFP-retroviral vectors (see all 2): NM_031477

Sigma-Aldrich siRNA for YPEL3

Sigma-Aldrich shRNA for YPEL3

Explore Sigma-Aldrich super-pooled esiRNAs

Applied Biosystems Silencer® siRNAs:

NM_031477

REFSEQ mRNAs for YPEL3 gene (2 alternative transcripts):

NM_001145524.1 NM_031477.4

Applied Biosystems TaqMan ® Gene Expression Assays:

NM_031477

               OriGene GFP tagged cDNA clones in CMV expression vector (see all 2): NM_001145524
                                 Myc/DDK tagged cDNA clones in CMV expression vector (see all 2): NM_001145524
                                 untagged cDNA clones in CMV expression vector (see all 4): AK022409

Additional cDNA sequence:

AB098737.1 AF305622.1 AK022409.1 AK026047.1 AL359610.1 BC005009.1 BC050664.1 CR598881.1

CR604822.1 CR606841.1 CR611674.1 CR623470.1

14 DOTS entries:

DT.452139 DT.100024056 DT.97842587 DT.97842588 DT.91762394 DT.95272609 DT.120695071 DT.120695860

DT.95107770 DT.95272610 DT.120695432 DT.40118507 DT.91748024 DT.100696780

24/162 AceView cDNA sequences (see all 162 ):

AI304823 CR604822 AW072082 AK026047 AA342171 BQ787397 BM709084 CR598881

AI348611 AW161040 F29204 CR606841 BQ710636 BX351623 BC005009 CR623470

BU070387 CB306825 AI568781 AA933695 AI318382 AI804817 BM762254 AI318383

highest scoring ESTs for YPEL3:

AA490511 AF305622 AI830095 AK022409 AK026047 AL531933 AL555324 AL566375 AL568887 AL577858

Unigene Cluster for YPEL3:

Yippee-like 3 (Drosophila)

Hs.513491 [show with all ESTs]

Unigene Representative Sequence: AK022409

GeneLoc Exon Structure

5/7 Alternative Splicing Database (ASD) splice patterns (SP) for YPEL3 (see all 7 )

ExUns:	1	^	2a	·	2b	^	3a	·	3b	·	3c	·	3d	^	4a	·	4b	·	4c	^	5a	·	5b	·	5c	^	6a	·	6b	·	6c
SP1:			-		-		-		-								-		-						-
SP2:							-		-								-		-						-
SP3:							-		-										-
SP4:							-		-		-						-		-
SP5:																	-		-						-

About this scheme

ECgene alternative splicing isoforms for YPEL3

3 Ensembl transcripts including schematic representations:

ENST00000398838 ENST00000398841 ENST00000204279

(Experimental results according to ¹GeneNote and GNF BioGPS,
probe sets-to-genes annotations according to ²GeneAnnot , ³GeneTide , Sets of similar genes according to GeneDecks, Electronic Northern calculations according to data from UniGene (Build 219 Homo sapiens), SAGE tags according to CGAP, plus additional links to SOURCE, and/or GNF BioGPS, and/or EXPOLDB, and/or UniProtKB,
Expression Assays from Applied Biosystems )
About This Section

YPEL3 expression in normal and diseased human tissues

Applied Biosystems TaqMan ® Gene Expression Assays for YPEL3

¹ / ² / ³

6 probe-sets matching YPEL3 gene

Affymetrix probe-set	Array	# genes	Sensitivity	Specificity	Correlation	Length	Gb_Accession	Consensus	Uniqueness	Score	Rank
Affymetrix probe-set	Array	GeneAnnot data			GeneNote data		GeneTide data
60848_at²^{, 3}	U95-C	1	1.00	1.00	0.68	0.91	H04096	0.60	1.00	0.82	1
63369_at²^{, 3}	U95-C	2	1.00	0.97	0.97	1.10	AI830095	0.80	1.00	0.91	1
232077_s_at²^{, 3}	U133-B	1	1.00	1.00	--	--	AU147979	0.20	1.00	0.72	1
223179_at²^{, 3}	U133-B	1	1.00	1.00	--	--	BC005009	0.80	1.00	0.91	1
232077_s_at²	U133Plus2	1	1.00	1.00	--	--	--	--	--	--	--
223179_at²	U133Plus2	1	1.00	1.00	--	--	--	--	--	--	--

About this table

Data from

(Publications) and GNF BioGPS
About these images
About these images

CGAP SAGE TAG: CACTGTGACC

SOURCE GeneReport for Unigene cluster: Hs.513491
UniProtKB/Swiss-Prot: YPEL3_HUMAN, P61236
Tissue specificity: Widely expressed

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD and/or ⁵MGI Jun 06 2009, with possible further links to Flybase and/or WormBase, Gene Trees according to Ensembl)
About This Section

Orthologs for YPEL3 gene from 5/10 species (see all 10 )

Organism	Gene	Locus	Description	Human Similarity	NCBI accessions
chimpanzee (Pan troglodytes)	YPEL3¹	--	yippee-like 3 (Drosophila)	98.61(n) 97.22(a)	467945 XM_523338.2 XP_523338.2
cow (Bos taurus)	YPEL3¹	--	yippee-like 3 (Drosophila)	96.95(n) 98.59(a)	787498 XM_001254874.1 XP_001254875.1
rat (Rattus norvegicus)	RGD1564579¹	--	similar to yippee-like 3	91.94(n) 94.12(a)	293491 XM_215057.4 XP_215057.4
mouse (Mus musculus)	Ypel3^{1, 5}	7⁵	yippee-like 3 (Drosophila)^{1, 5}	95.52(n)¹ 100(a)¹	66090¹ NM_025347.2¹ NP_079623.1¹ AA797224⁵ AB098742⁵ (see all 17)
zebrafish (Danio rerio)	LOC100004727¹	--	similar to yippee-like 1	77.04(n) 82.22(a)	100004727 XM_001343922.2 XP_001343958.2

About this table Species with no ortholog for YPEL3

ENSEMBL Gene Tree for YPEL3

(Paralogs according to ¹HomoloGene
and ²Ensembl, Pseudogenes according to ³Pseudogene.org)
About This Section

Paralogs for YPEL3 gene

YPEL1² YPEL2² YPEL4² YPEL5²

(According to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, and UniProtKB, Linkage Disequilibrium by HapMap, Genotyping Reagents from Applied Biosystems)
About This Section

7 NCBI SNPs in YPEL3 are shown
(Click for Applied Biosystems TaqMan ® Genotyping Assay) (only AB snps)

AB	SNP ID	Valid	Chr 16 pos	Sequence	Recs	AA Chg	Type	More	Recs	Allele freq	Pop	Total sample	More
AB	Genomic Data				Transcription Data				Allele Frequencies
				--	--	--		--	--				--
--	rs12444973^1,2	C	30014786(+)	`CTGCAA/TCGCGG`	1	--	ut5¹		0	--	--	--	--
	rs3809627^1,2	C	30010661(+)	`CCATCA/CCGAGC`	1	--	ng5¹		0	--	--	--	--
--	rs62057755^1,2	--	30016935(+)	`CCCTCA/CTAGGA`	1	--	ng3¹		0	--	--	--	--
--	rs73530179^1,2	--	30015282(+)	`TCGGAA/GGGTCT`	1	--	ng3¹		0	--	--	--	--
--	rs71389445^1,2	--	30013668(+)	`GCATGA/GAGGCC`	1	L/L	syn¹		0	--	--	--	--
--	rs35445351^1,2	--	30013252(-)	`AGACA-/GGGGAG`	1	--	int¹		0	--	--	--	--
--	rs34541261^1,2	--	30013402(-)	`TGGAT-/CCCCCA`	1	--	int¹		0	--	--	--	--

About this table
The following additional 22 SNP(s) have been found in Applied Biosystems data source:

(Click for Applied Biosystems TaqMan ® Genotyping Assay)

rs3809626	rs1043065	rs2289292	rs11641307	rs3809624	rs1042997	rs61736370
rs1044634	rs8060511	rs3809625	rs6565174	rs8057594	rs12927492	rs2278557
rs4785	rs11861842	rs2289291	rs1044584	rs35175583	rs61738521	rs1044572
rs7188971

HapMap Linkage Disequilibrium images for YPEL3 (up to first 250kb)

(in which this Gene is Involved, According to OMIM, UniProtKB, PharmGKB, Genatlas, GeneTests, Blood group antigen gene mutations by BGMUT, HGMD, GAD, HuGE Navigator, BCGD, and/or TGDB.)
About This Section

OMIM: 609724

(Possibly Related Articles in Doctor's Guide)
About This Section

(in PubMed. Associations of this gene to articles via ¹Novoseek, ²HGNC, ³Entrez Gene, ⁴UniProtKB/Swiss-Prot, ⁵UniProtKB/TrEMBL, ⁶GAD, and/or ⁷PharmGKB)
About This Section

5 PubMed articles for YPEL3 gene:

Identification and characterization of a novel gene family YPEL in a wide spectrum of eukaryotic species. (PubMed id 15556292)^{3, 4} Hosono K.... Shimizu N. (2004)
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)^{3, 4} Gerhard D.S....Malek J. (2004)
The sequence and analysis of duplication-rich human chromosome 16. (PubMed id 15616553)⁴ Martin J.... Pennacchio L.A. (2004)
Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)³ Ota T....Sugano S. (2004)
Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)³ Strausberg R.L....Marra M.A. (2002)

(in PubMed, OMIM, and NCBI Bookshelf)
About This Section

		AND	OR
Aliases
Free Text

Query String		PubMed OMIM NCBI Bookshelf
	(Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, and/or H-InvDB)
About This Section

Entrez Gene: 83719	HGNC: 18327	AceView: YPEL3	Ensembl:ENSG00000090238	euGenes: HUgn83719
ECgene: YPEL3	H-InvDB: YPEL3

(According to HUGE)
About This Section

(According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section

Licensable Technologies for YPEL3
(Available from WIS Yeda, Salk, Tufts)

About This Section

(Reagents available from Applied Biosystems, Antibodies and assays by Cell Signaling Technology, Abcam, Novus Biologicals,
Sigma-Aldrich, R&D Systems, Millipore, Abnova, and/or Invitrogen, Clones available from OriGene,and/or Invitrogen, Drugs and/or compounds by Sigma-Aldrich,
Enzo Life Sciences, and/or Tocris Bioscience)
About This Section

Products for YPEL3:

TaqMan ® Gene Expression Assays

TaqMan ® Genotyping Assays

Free SNP selection tool

Invitrogen iPath Pathways	Invitrogen BLOCK-iT™ RNAi
Invitrogen Antibodies	Invitrogen Assays
Invitrogen Clones	Invitrogen Q-PCR Products
Invitrogen Human Recombinant Kinases	Invitrogen Custom Antibody and Peptide Service
Invitrogen Proteins / Assays / Screening Services	Search Invitrogen catalog for YPEL3-related products

	Millipore Custom Antibody & Bulk Services
	Millipore Preclinical / Clinical Development Services
	Millipore Immunoassay Services
	Millipore Target Screening & Profiling Services

	Predesigned and custom siRNAs for YPEL3		Browse antibodies at Sigma-Aldrich
	Explore super-pooled esiRNAs		Browse proteins at Sigma-Aldrich
	Lentivirus-delivered shRNAs for YPEL3		Browse small molecules at Sigma-Aldrich
	"Your Favorite Gene" Pathways		feedback

	Antibodies		Primer Pairs
	Cell Culture Products		ELISAs
	Flow Cytometry Kits		Protease Activity Assays & Reagents
	Cell Selection/Detection Kits & Reagents		ELISA/Assay Development Kits & Reagents
	Multiplex/Array Assay Kits & Reagents		ELISpot Kits & Development Modules
	Recombinant & Natural Proteins

	Recombinant Proteins (YPEL3)
	Search for Antibodies
	Search for Chimera RNAi
	Custom Service for Mouse Mab
	Custom Service for Rabbit Pab from Full-length Protein

Search for Antibodies & Assays

	Search for Recombinant Proteins
	Search for Antibodies

Search OriGene for YPEL3

Search Tocris compounds for YPEL3

Search www.enzolifesicences.com for proteins, assays, substrates, inhibitors & antibodies

Search Novus for antibodies for YPEL3

GeneCards Homepage - Last full update: 2 Jul 2009 Incremental update: 13 Oct 2009

Random Gene From GIFtS :

about GIFtS

Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

Developed at the Crown Human Genome Center & Weizmann Institute of Science

The GeneCards Human Gene Database: Copyright © 1996-2009, Weizmann Institute of Science. All Rights Reserved.
YPEL3 Gene at Home site.
Version 2.41.1
server5.xennexinc.com

YPEL3 Gene

protein-coding GIFtS: 46

Aliases &
Descriptions
for YPEL3

Summaries
for YPEL3

Genomic Location
for YPEL3

Proteins
for YPEL3

Protein Domains/
Families
for YPEL3

Gene Function
for YPEL3

Pathways & Interactions
for YPEL3

Drugs & Compounds
for YPEL3

Transcripts
for YPEL3

Expression
for YPEL3

Orthologs
for YPEL3

Paralogs
for YPEL3

SNPs/Variants
for YPEL3

Disorders & Mutations
for YPEL3

Medical News
for YPEL3

Publications
for YPEL3

Search for YPEL3

Genome Databases showing YPEL3

Other Databases showing YPEL3

Specialized Databases showing YPEL3

Licensable Technologies
for YPEL3

Services
for YPEL3

Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

YPEL3 Gene

protein-coding GIFtS: 46

Aliases & Descriptionsfor YPEL3

Summariesfor YPEL3

Genomic Locationfor YPEL3

Proteinsfor YPEL3

Protein Domains/Familiesfor YPEL3

Gene Functionfor YPEL3

Pathways & Interactionsfor YPEL3

Drugs & Compoundsfor YPEL3

Transcriptsfor YPEL3

Expression for YPEL3

Orthologsfor YPEL3

Paralogsfor YPEL3

SNPs/Variantsfor YPEL3

Disorders & Mutationsfor YPEL3

Medical Newsfor YPEL3

Publicationsfor YPEL3

Search for YPEL3

Genome Databases showing YPEL3

Other Databases showing YPEL3

Specialized Databases showing YPEL3

Licensable Technologiesfor YPEL3

Servicesfor YPEL3

Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

Aliases &
Descriptions
for YPEL3

Summaries
for YPEL3

Genomic Location
for YPEL3

Proteins
for YPEL3

Protein Domains/
Families
for YPEL3

Gene Function
for YPEL3

Pathways & Interactions
for YPEL3

Drugs & Compounds
for YPEL3

Transcripts
for YPEL3

Expression
for YPEL3

Orthologs
for YPEL3

Paralogs
for YPEL3

SNPs/Variants
for YPEL3

Disorders & Mutations
for YPEL3

Medical News
for YPEL3

Publications
for YPEL3

Licensable Technologies
for YPEL3

Services
for YPEL3