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Aliases for YPEL2 Gene

Aliases for YPEL2 Gene

  • Yippee-Like 2 (Drosophila) 2 3
  • DiGeorge Syndrome-Related Protein 3
  • Protein Yippee-Like 2 3
  • FKSG4 3

External Ids for YPEL2 Gene

Previous GeneCards Identifiers for YPEL2 Gene

  • GC17P057883
  • GC17P054763
  • GC17P057409
  • GC17P052768

Summaries for YPEL2 Gene

GeneCards Summary for YPEL2 Gene

YPEL2 (Yippee-Like 2 (Drosophila)) is a Protein Coding gene. An important paralog of this gene is YPEL5.

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for YPEL2 Gene

Genomics for YPEL2 Gene

Regulatory Elements for YPEL2 Gene

Genomic Location for YPEL2 Gene

Start:
59,331,689 bp from pter
End:
59,401,734 bp from pter
Size:
70,046 bases
Orientation:
Plus strand

Genomic View for YPEL2 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for YPEL2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for YPEL2 Gene

Proteins for YPEL2 Gene

  • Protein details for YPEL2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q96QA6-YPEL2_HUMAN
    Recommended name:
    Protein yippee-like 2
    Protein Accession:
    Q96QA6
    Secondary Accessions:
    • A0PK16
    • A2RUG4
    • Q65ZA0
    • Q8N3W2

    Protein attributes for YPEL2 Gene

    Size:
    119 amino acids
    Molecular mass:
    13577 Da
    Quaternary structure:
    • May interact with FAM168B

neXtProt entry for YPEL2 Gene

Proteomics data for YPEL2 Gene at MOPED

Post-translational modifications for YPEL2 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for YPEL2 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for YPEL2 Gene

Domains for YPEL2 Gene

Protein Domains for YPEL2 Gene

InterPro:
Blocks:
ProtoNet:

Suggested Antigen Peptide Sequences for YPEL2 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q96QA6

UniProtKB/Swiss-Prot:

YPEL2_HUMAN :
  • Q96QA6
Family:
  • Belongs to the yippee family.
genes like me logo Genes that share domains with YPEL2: view

No data available for Gene Families for YPEL2 Gene

Function for YPEL2 Gene

miRNA for YPEL2 Gene

miRTarBase miRNAs that target YPEL2

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Phenotypes , Animal Models , Transcription Factor Targeting and HOMER Transcription for YPEL2 Gene

Localization for YPEL2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for YPEL2 Gene

Nucleus, nucleolus.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for YPEL2 Gene COMPARTMENTS Subcellular localization image for YPEL2 gene
Compartment Confidence
nucleus 5
extracellular 2
mitochondrion 2
cytosol 1

Gene Ontology (GO) - Cellular Components for YPEL2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus --
GO:0005730 nucleolus IEA --
genes like me logo Genes that share ontologies with YPEL2: view

Pathways for YPEL2 Gene

SuperPathways for YPEL2 Gene

No Data Available

Interacting Proteins for YPEL2 Gene

Gene Ontology (GO) - Biological Process for YPEL2 Gene

None

No data available for Pathways by source for YPEL2 Gene

Transcripts for YPEL2 Gene

Unigene Clusters for YPEL2 Gene

Yippee-like 2 (Drosophila):
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for YPEL2 Gene

No ASD Table

Relevant External Links for YPEL2 Gene

GeneLoc Exon Structure for
YPEL2
ECgene alternative splicing isoforms for
YPEL2

Expression for YPEL2 Gene

mRNA expression in normal human tissues for YPEL2 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

SOURCE GeneReport for Unigene cluster for YPEL2 Gene Hs.463613

mRNA Expression by UniProt/SwissProt for YPEL2 Gene

Q96QA6-YPEL2_HUMAN
Tissue specificity: Widely expressed. Detected in fetal and adult kidney, heart, liver, lung and skeletal muscle.
genes like me logo Genes that share expressions with YPEL2: view

No data available for mRNA differential expression in normal tissues and Protein expression for YPEL2 Gene

Orthologs for YPEL2 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for YPEL2 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia YPEL2 35
  • 99.72 (n)
  • 100 (a)
YPEL2 36
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia YPEL2 35
  • 94.12 (n)
  • 100 (a)
YPEL2 36
  • 100 (a)
OneToOne
dog
(Canis familiaris)
Mammalia YPEL2 35
  • 96.64 (n)
  • 100 (a)
YPEL2 36
  • 100 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Ypel2 35
  • 93.56 (n)
  • 100 (a)
Ypel2 16
Ypel2 36
  • 100 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia YPEL2 36
  • 36 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia YPEL2 36
  • 98 (a)
OneToOne
chicken
(Gallus gallus)
Aves YPEL2 35
  • 89.92 (n)
  • 100 (a)
YPEL2 36
  • 100 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia YPEL2 36
  • 62 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia ypel2 35
  • 84.31 (n)
  • 100 (a)
zebrafish
(Danio rerio)
Actinopterygii LOC100004727 35
  • 81.32 (n)
  • 98.28 (a)
ypel2a 36
  • 91 (a)
OneToMany
ypel2b 36
  • 97 (a)
OneToMany
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP011563 35
  • 73.91 (n)
  • 88.7 (a)
fruit fly
(Drosophila melanogaster)
Insecta CG15309 35
  • 72.92 (n)
  • 88.39 (a)
CG15309 36
  • 89 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea F37A8.5 36
  • 72 (a)
OneToMany
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes MOH1 36
  • 36 (a)
OneToMany
thale cress
(Arabidopsis thaliana)
eudicotyledons AT5G53940 35
  • 58.42 (n)
  • 51.55 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 78 (a)
OneToMany
Species with no ortholog for YPEL2:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for YPEL2 Gene

ENSEMBL:
Gene Tree for YPEL2 (if available)
TreeFam:
Gene Tree for YPEL2 (if available)

Paralogs for YPEL2 Gene

Paralogs for YPEL2 Gene

Selected SIMAP similar genes for YPEL2 Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with YPEL2: view

Variants for YPEL2 Gene

Sequence variations from dbSNP and Humsavar for YPEL2 Gene

SNP ID Clin Chr 17 pos Sequence Context AA Info Type MAF
rs2520 -- 59,397,614(-) CCACC(A/C)TTCCA utr-variant-3-prime
rs10599 -- 59,397,562(+) CGTGA(A/G)GAAGA utr-variant-3-prime
rs12060 -- 59,397,457(-) AGGAT(A/C)TGTTC utr-variant-3-prime
rs716317 -- 59,333,280(+) TCCCC(A/C)GCTCC intron-variant
rs728478 -- 59,389,143(+) ATTTC(A/G)GTAGA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for YPEL2 Gene

Variant ID Type Subtype PubMed ID
dgv995e1 CNV Complex 17122850
nsv833500 CNV Loss 17160897
nsv908649 CNV Gain 21882294
esv7723 CNV Gain 19470904
nsv527058 CNV Loss 19592680

Relevant External Links for YPEL2 Gene

HapMap Linkage Disequilibrium report
YPEL2

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for YPEL2 Gene

Disorders for YPEL2 Gene

Relevant External Links for YPEL2

Genetic Association Database (GAD)
YPEL2
Human Genome Epidemiology (HuGE) Navigator
YPEL2
genes like me logo Genes that share disorders with YPEL2: view

No data available for UniProtKB/Swiss-Prot for YPEL2 Gene

Publications for YPEL2 Gene

  1. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4
  2. Identification and characterization of a novel gene family YPEL in a wide spectrum of eukaryotic species. (PMID: 15556292) Hosono K. … Shimizu N. (Gene 2004) 3 4
  3. Centrosome-related genes, genetic variation, and risk of breast cancer. (PMID: 20508983) Olson J.E. … Couch F.J. (Breast Cancer Res. Treat. 2011) 3 48
  4. The protein interaction landscape of the human CMGC kinase group. (PMID: 23602568) Varjosalo M. … Gstaiger M. (Cell Rep 2013) 3
  5. Genetic variation in the chromosome 17q23 amplicon and breast cancer risk. (PMID: 19454617) Kelemen L.E. … Couch F.J. (Cancer Epidemiol. Biomarkers Prev. 2009) 48

Products for YPEL2 Gene

Sources for YPEL2 Gene

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