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YPEL2 Gene

protein-coding GIFtS: 46

GC17P054763

yippee-like 2 (Drosophila)
Symbol approved by the HUGO Gene Nomenclature Committee (HGNC) database

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc , and/or ⁷Ensembl, ⁸miRBase)
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Aliases
DKFZp761C2021 ^²
FKSG4 ^¹, ²

Descriptions
DiGeorge syndrome-related protein ^²
yippee-like 2 ^²
yippee-like 2 (Drosophila) ^²

External Ids
HGNC: 18326¹
Entrez Gene: 388403²
UniProtKB: Q96QA6³
Ensembl: ENSG00000175155⁷

Search outside databases for aliases for YPEL2 gene

Previous GC identifer: GC17P057883

(According to Entrez Gene, Wikipedia's Gene Wiki,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 36),
and/or miRBase,
Genomic Views according to UCSC and Ensembl, Transcription factor binding sites according to SABiosciences)
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Genomic View:

UCSC Golden Path with GeneCards custom track

Transcription factor binding sites upstream to the YPEL2 gene

Entrez Gene cytogenetic band: 17q22 Ensembl cytogenetic band: 17q22 HGNC cytogenetic band: 17q23

YPEL2 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)

GeneLoc gene densities for chromosome 17 GeneLoc Exon Structure

GeneLoc location for GC17P054763: (about GC identifiers)

Start:	54,763,835 bp from pter
End:	54,833,877 bp from pter
Size:	70,043 bases
Orientation:	plus strand

RefSeq DNA sequence:

NC_000017.9 NT_010783.14

(According to ¹UniProtKB, and/or Ensembl, Phosphorylation sites according to ²Phosphosite, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Enzo Life Sciences, Abnova, OriGene and/or, Abcam,
Biochemical Assays by Invitrogen, Millipore, R&D Systems, Cell Signaling Technology, and/or Enzo Life Sciences, Ontologies according to Gene Ontology Consortium 01 Apr 2009 and Entrez Gene, Antibodies by Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Cell Signaling Technology, Abcam, Abnova, and/or Novus Biologicals)
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UniProtKB/Swiss-Prot: YPEL2_HUMAN, Q96QA6 (See protein sequence)

Recommended Name: Protein yippee-like 2

Size: 119 amino acids; 13577 Da

Subcellular location: Nucleus, nucleolus

Secondary accessions: A0PK16 A2RUG4 Q65ZA0 Q8N3W2

Post-translational modifications:

View phosphorylation sites using PhosphoSite²

REFSEQ proteins: NP_001005404.1

ENSEMBL proteins:

ENSP00000312272

Human Recombinant Proteins

	Browse Drug Discovery Central at Invitrogen for human recombinant proteins
	Browse Purified and Recombinant Proteins at Millipore
	Browse Human Recombinant Proteins at Sigma-Aldrich
	Browse R&D Systems for human recombinant proteins
	Browse recombinant and purified proteins available from Enzo Life Sciences
	Browse Abcam for Recombinant Proteins
	Browse Abnova for Human Recombinant Proteins

OriGene Purified Recombinant Human Protein: YPEL2

1 Gene Ontology (GO) cellular component term (links to tree view):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005634	nucleus	IEA	--

About this table

Antibodies for YPEL2:

	Browse Antibodies Central at Invitrogen
	Browse Millipore's Extensive Line of Mono- and Polyclonal Antibodies
	Browse Antibodies at Sigma-Aldrich
	Browse R&D Systems for Antibodies
	Search for antibodies at Abcam and the World's Antibody Gateway (free search engine of over 150 antibody companies)
	Browse Abnova for Monoclonal and Polyclonal Antibodies
	Search Novus for antibodies for YPEL2

Assays for YPEL2:

	Browse Invitrogen for biochemical assays
	Browse Kits and Assays available from Millipore
	Browse R&D Systems for biochemical assays
	Browse biochemical assays available from Enzo Life Sciences

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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Graphical View of Domain Structure for InterPro Entry Q96QA6

ProtoNet protein and cluster: Q96QA6

1 Blocks protein family: IPB004910 Yippee-like protein

UniProtKB/Swiss-Prot: YPEL2_HUMAN, Q96QA6

Similarity: Belongs to the yippee family

(According to MGI Jun 06 2009, UniProtKB, IUBMB,and/or Genatlas,
shRNA from OriGene, Sigma-Aldrich, RNAi from Sigma-Aldrich,
RNAi Products, Clones, and Q-PCR Products from Invitrogen, Millipore, OriGene, and/or Abnova, siRNAs from Applied Biosystems, SYBR primers from OriGene, Cell-based Assays from Millipore, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
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Inhib. RNA:		Invitrogen RNAi Products for gene knock-down (YPEL2)
		Browse for Gene Knock-down Tools from Millipore
		Browse Abnova for Chimera RNAi Products

OriGene 29mer shRNA kit in GFP-retroviral vector: NM_001005404

Applied Biosystems Silencer® siRNAs for YPEL2

Sigma-Aldrich siRNA and siRNA Panels for YPEL2

Sigma-Aldrich shRNA for YPEL2

Explore Sigma-Aldrich super-pooled esiRNAs

Clones:		Browse Clone Ranger at Invitrogen for clones
		Browse Clones for the Expression of Recombinant Proteins Available from Millipore

OriGene GFP tagged cDNA clone in CMV expression vector: NM_001005404
Myc/DDK tagged cDNA clone in CMV expression vector: NM_001005404
untagged cDNA clone in CMV expression vector: NM_001005404

Primers:

Browse Quantitative PCR Central at Invitrogen for Q-PCR LUX™ Primers

OriGene genome-wide validated SYBR primer pairs: NM_001005404

(Pathways according to Invitrogen (maps by GeneGo), Millipore, Cell Signaling Technology, Sigma-Aldrich, KEGG and/or UniProtKB,
Sets of similar genes according to GeneDecks, Proteins Network according to SABiosciences, Interactions according to ¹UniProtKB, ²MINT, and/or ³STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
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(Chemical Compounds according to UniProtKB, Enzo Life Sciences, Sigma-Aldrich, Tocris Bioscience, and/or Novoseek and Drugs according to Enzo Life Sciences and/or PharmGKB)
About This Section

Browse drugs & compounds from Enzo Life Sciences

Browse Small Molecules at Sigma-Aldrich

Browse Tocris compounds for YPEL2

(GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 219 Homo sapiens; Jun 2 2009) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView,
non coding RNAs according to RNAdb,
ESTs according to GeneTide,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from Invitrogen, Millipore, and/or Abnova,
siRNAs from Applied Biosystems, Sigma-Aldrich,
shRNA from Sigma-Aldrich, OriGene,
Tagged/untagged cDNA clones from OriGene,
Expression Assays from Applied Biosystems)
About This Section

Inhib. RNA:		Invitrogen RNAi Products for gene knock-down (YPEL2)
		Browse for Gene Knock-down Tools from Millipore
		Browse Abnova for Chimera RNAi Products

OriGene 29mer shRNA kit in GFP-retroviral vector: NM_001005404

Sigma-Aldrich siRNA and siRNA Panels for YPEL2

Sigma-Aldrich shRNA for YPEL2

Explore Sigma-Aldrich super-pooled esiRNAs

Applied Biosystems Silencer® siRNAs:

NM_001005404

REFSEQ mRNAs for YPEL2 gene:

NM_001005404.3

Applied Biosystems TaqMan ® Gene Expression Assays:

NM_001005404

              OriGene GFP tagged cDNA clone in CMV expression vector: NM_001005404
                                 Myc/DDK tagged cDNA clone in CMV expression vector: NM_001005404
                                 untagged cDNA clone in CMV expression vector: NM_001005404

Additional cDNA sequence:

AB098736.1 AF305195.1 AK096866.1 BC127924.1 BC132884.1 BC132886.1

5 DOTS entries:

DT.101957097 DT.412172 DT.120930241 DT.40127622 DT.95161422

24/102 AceView cDNA sequences (see all 102 ):

BF448974 AI149779 AA588481 CD673236 N59155 BE042903 AW241652 BU633932

AA903218 AA242807 AI208796 BQ272526 AI284077 AI985541 AA983913 AA604677

BE858915 AL831930 BM264556 BU783882 CA445996 BF195961 AI128325 AI814795

highest scoring ESTs for YPEL2:

AW005748 AA018664 AA018665 AA046023 AA046075 AA204707 AA242807 AA280716 AA281431 AA287724

Unigene Cluster for YPEL2:

Yippee-like 2 (Drosophila)

Hs.463613 [show with all ESTs]

Unigene Representative Sequence: NM_001005404

GeneLoc Exon Structure

1 Ensembl transcript including schematic representation:

ENST00000312655

(Experimental results according to ¹GeneNote and GNF BioGPS,
probe sets-to-genes annotations according to ²GeneAnnot , ³GeneTide , Sets of similar genes according to GeneDecks, Electronic Northern calculations according to data from UniGene (Build 219 Homo sapiens), SAGE tags according to CGAP, plus additional links to SOURCE, and/or GNF BioGPS, and/or EXPOLDB, and/or UniProtKB,
Expression Assays from Applied Biosystems )
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YPEL2 expression in normal and diseased human tissues

Applied Biosystems TaqMan ® Gene Expression Assays for YPEL2

¹ / ² / ³

8 probe-sets matching YPEL2 gene

Affymetrix probe-set	Array	# genes	Sensitivity	Specificity	Correlation	Length	Gb_Accession	Consensus	Uniqueness	Score	Rank
Affymetrix probe-set	Array	GeneAnnot data			GeneNote data		GeneTide data
50359_at²^{, 3}	U95-B	1	1.00	1.00	0.57	1.50	AI887904	0.60	1.00	0.82	1
50225_s_at²^{, 3}	U95-C	1	1.00	1.00	0.87	0.96	AW005748	0.80	1.00	0.91	1
77492_at²^{, 3}	U95-D	1	1.00	1.00	0.66	0.55	AI149779	0.60	1.00	0.82	1
229060_at²^{, 3}	U133-B	1	1.00	1.00	--	--	AW005748	0.80	1.00	0.91	1
227020_at²^{, 3}	U133-B	1	1.00	1.00	--	--	BE502982	0.60	1.00	0.82	1
1556420_s_at²	U133Plus2	1	1.00	1.00	--	--	--	--	--	--	--
229060_at²	U133Plus2	1	1.00	1.00	--	--	--	--	--	--	--
227020_at²	U133Plus2	1	1.00	1.00	--	--	--	--	--	--	--

About this table

Data from

(Publications) and GNF BioGPS
About these images
About these images

CGAP SAGE TAG: TTACCAAATT

SOURCE GeneReport for Unigene cluster: Hs.463613
UniProtKB/Swiss-Prot: YPEL2_HUMAN, Q96QA6
Tissue specificity: Widely expressed. Detected in fetal and adult kidney, heart, liver, lung and
skeletal muscle

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD and/or ⁵MGI Jun 06 2009, with possible further links to Flybase and/or WormBase, Gene Trees according to Ensembl)
About This Section

Orthologs for YPEL2 gene from 5/17 species (see all 17 )

Organism	Gene	Locus	Description	Human Similarity	NCBI accessions
dog (Canis familiaris)	YPEL2¹	--	yippee-like 2 (Drosophila)	96.64(n) 100(a)	610066 XM_847459.1 XP_852552.1
cow (Bos taurus)	YPEL2¹	--	yippee-like 2 (Drosophila)	94.12(n) 100(a)	616180 XM_001251637.1 XP_001251638.1
mouse (Mus musculus)	Ypel2^{1, 5}	11⁵	yippee-like 2 (Drosophila)^{1, 5}	93.56(n)¹ 100(a)¹	77864¹ NM_001005341.3¹ NP_001005341.1¹ AB098741⁵ AK021387⁵ (see all 13)
chicken (Gallus gallus)	YPEL2¹	--	yippee-like 2 (Drosophila)	89.92(n) 100(a)	417632 NM_001007847.1 NP_001007848.1
zebrafish (Danio rerio)	LOC561851¹	--	similar to Protein yippee-like 1	82.35(n) 97.48(a)	561851 XM_685254.3 XP_690346.1

About this table Species with no ortholog for YPEL2

ENSEMBL Gene Tree for YPEL2

(Paralogs according to ¹HomoloGene
and ²Ensembl, Pseudogenes according to ³Pseudogene.org)
About This Section

Paralogs for YPEL2 gene

YPEL1² YPEL3² YPEL4² YPEL5²

(According to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, and UniProtKB, Linkage Disequilibrium by HapMap, Genotyping Reagents from Applied Biosystems)
About This Section

10/348 NCBI SNPs in YPEL2 are shown (see all 348 )
(Click for Applied Biosystems TaqMan ® Genotyping Assay) (see all 95)

AB	SNP ID	Valid	Chr 17 pos	Sequence	Recs	AA Chg	Type	More	Recs	Allele freq	Pop	Total sample	More
AB	Genomic Data				Transcription Data				Allele Frequencies
				--	--	--		--	--				--
	rs1451508^1,2	A,C,F,H	54832017(-)	`CAATTC/ACCCCA`	1	--	ut3¹		6		MN EA EU WA	2088
	rs8072004^1,2	A,C,F,H	54763354(+)	`GGTAAC/TTTAGG`	1	--	ng5¹		8		EU EA WA	832
	rs1451507^1,2	A,C,F	54832055(-)	`CTCCCC/AACACC`	1	--	ut3¹		2		MN EA	1686
	rs9905500^1,2	A,C	54830678(+)	`TCCAAA/GCATCC`	1	--	ut3¹ ese³		0	--	--	--	--
	rs758379^1,2	C,F	54832398(+)	`TGTGCA/GAAAGA`	1	--	ut3¹ ese³		5		MN NA EA	546
	rs7221185^1,2	A,C	54831435(+)	`TGGACC/TCTTTC`	1	--	ut3¹ ese³ trp³		0	--	--	--	--
	rs7220373^1,2	A,C	54832851(+)	`AATTTC/GCAACA`	1	--	ut3¹		0	--	--	--	--
	rs10853012^1,2	A,C	54833058(+)	`TTGAGA/TATGGA`	1	--	ut3¹ ese³		0	--	--	--	--
	rs12601869^1,2	C	54831670(+)	`TTCTGA/CATGTT`	1	--	ut3¹		0	--	--	--	--
	rs1046037^1,2	F	54833035(+)	`AGCAGA/CACCCA`	1	--	ut3¹ ese³		1		MN	184

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HapMap Linkage Disequilibrium images for YPEL2 (up to first 250kb)

(in which this Gene is Involved, According to OMIM, UniProtKB, PharmGKB, Genatlas, GeneTests, Blood group antigen gene mutations by BGMUT, HGMD, GAD, HuGE Navigator, BCGD, and/or TGDB.)
About This Section

OMIM: 609723

Human Genome Epidemiology Navigator: YPEL2 (2 documents)

(Possibly Related Articles in Doctor's Guide)
About This Section

(in PubMed. Associations of this gene to articles via ¹Novoseek, ²HGNC, ³Entrez Gene, ⁴UniProtKB/Swiss-Prot, ⁵UniProtKB/TrEMBL, ⁶GAD, and/or ⁷PharmGKB)
About This Section

5 PubMed articles for YPEL2 gene:

Identification and characterization of a novel gene family YPEL in a wide spectrum of eukaryotic species. (PubMed id 15556292)^{3, 4} Hosono K.... Shimizu N. (2004)
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)^{3, 4} Gerhard D.S....Malek J. (2004)
Distinct genetic loci control plasma HIV-RNA and cellular HIV-DNA levels in HIV-1 infection: the ANRS Genome Wide Association 01 study. (PubMed id 19107206)³ Dalmasso C....Theodorou I. (2008)
Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)³ Ota T....Sugano S. (2004)
Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)³ Strausberg R.L....Marra M.A. (2002)

(in PubMed, OMIM, and NCBI Bookshelf)
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		AND	OR
Aliases
Free Text

Query String		PubMed OMIM NCBI Bookshelf
	(Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, and/or H-InvDB)
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Entrez Gene: 388403	HGNC: 18326	AceView: YPEL2	Ensembl:ENSG00000175155	euGenes: HUgn388403
ECgene: YPEL2	H-InvDB: YPEL2

(According to HUGE)
About This Section

(According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section

Licensable Technologies for YPEL2
(Available from WIS Yeda, Salk, Tufts)

About This Section

(Reagents available from Applied Biosystems, Antibodies and assays by Cell Signaling Technology, Abcam, Novus Biologicals,
Sigma-Aldrich, R&D Systems, Millipore, Abnova, and/or Invitrogen, Clones available from OriGene,and/or Invitrogen, Drugs and/or compounds by Sigma-Aldrich,
Enzo Life Sciences, and/or Tocris Bioscience)
About This Section

Products for YPEL2:

TaqMan ® Gene Expression Assays

TaqMan ® Genotyping Assays

Free SNP selection tool

Invitrogen iPath Pathways	Invitrogen BLOCK-iT™ RNAi
Invitrogen Antibodies	Invitrogen Assays
Invitrogen Clones	Invitrogen Q-PCR Products
Invitrogen Human Recombinant Kinases	Invitrogen Custom Antibody and Peptide Service
Invitrogen Proteins / Assays / Screening Services	Search Invitrogen catalog for YPEL2-related products

	Millipore Custom Antibody & Bulk Services
	Millipore Preclinical / Clinical Development Services
	Millipore Immunoassay Services
	Millipore Target Screening & Profiling Services

	Predesigned and custom siRNAs for YPEL2		Browse antibodies at Sigma-Aldrich
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	Lentivirus-delivered shRNAs for YPEL2		Browse small molecules at Sigma-Aldrich
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	Multiplex/Array Assay Kits & Reagents		ELISpot Kits & Development Modules
	Recombinant & Natural Proteins

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	Purified proteins from HEK293T cells
	Western blot validated antibodies
	shRNA in GFP-retroviral vector

Search Tocris compounds for YPEL2

Search www.enzolifesicences.com for proteins, assays, substrates, inhibitors & antibodies

Search Novus for antibodies for YPEL2

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YPEL2 Gene

protein-coding GIFtS: 46

Aliases &
Descriptions
for YPEL2

Summaries
for YPEL2

Genomic Location
for YPEL2

Proteins
for YPEL2

Protein Domains/
Families
for YPEL2

Gene Function
for YPEL2

Pathways & Interactions
for YPEL2

Drugs & Compounds
for YPEL2

Transcripts
for YPEL2

Expression
for YPEL2

Orthologs
for YPEL2

Paralogs
for YPEL2

SNPs/Variants
for YPEL2

Disorders & Mutations
for YPEL2

Medical News
for YPEL2

Publications
for YPEL2

Search for YPEL2

Genome Databases showing YPEL2

Other Databases showing YPEL2

Specialized Databases showing YPEL2

Licensable Technologies
for YPEL2

Services
for YPEL2

Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

YPEL2 Gene

protein-coding GIFtS: 46

Aliases & Descriptionsfor YPEL2

Summariesfor YPEL2

Genomic Locationfor YPEL2

Proteinsfor YPEL2

Protein Domains/Familiesfor YPEL2

Gene Functionfor YPEL2

Pathways & Interactionsfor YPEL2

Drugs & Compoundsfor YPEL2

Transcriptsfor YPEL2

Expression for YPEL2

Orthologsfor YPEL2

Paralogsfor YPEL2

SNPs/Variantsfor YPEL2

Disorders & Mutationsfor YPEL2

Medical Newsfor YPEL2

Publicationsfor YPEL2

Search for YPEL2

Genome Databases showing YPEL2

Other Databases showing YPEL2

Specialized Databases showing YPEL2

Licensable Technologiesfor YPEL2

Servicesfor YPEL2

Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

Aliases &
Descriptions
for YPEL2

Summaries
for YPEL2

Genomic Location
for YPEL2

Proteins
for YPEL2

Protein Domains/
Families
for YPEL2

Gene Function
for YPEL2

Pathways & Interactions
for YPEL2

Drugs & Compounds
for YPEL2

Transcripts
for YPEL2

Expression
for YPEL2

Orthologs
for YPEL2

Paralogs
for YPEL2

SNPs/Variants
for YPEL2

Disorders & Mutations
for YPEL2

Medical News
for YPEL2

Publications
for YPEL2

Licensable Technologies
for YPEL2

Services
for YPEL2