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YPEL2 Gene

protein-coding   GIFtS: 46

GC17P054763
yippee-like 2 (Drosophila)
Symbol approved by the HUGO Gene Nomenclature Committee (HGNC) database
Services    
(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc , and/or 7Ensembl, 8miRBase)
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Aliases
DKFZp761C2021 2
FKSG4 1, 2
Descriptions
DiGeorge syndrome-related protein 2
yippee-like 2 2
yippee-like 2 (Drosophila) 2
External Ids
HGNC: 183261
Entrez Gene: 3884032
UniProtKB: Q96QA63
Ensembl: ENSG000001751557
Search outside databases for aliases for YPEL2 gene

Previous GC identifer: GC17P057883

(According to Entrez Gene, Wikipedia's Gene Wiki,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

  --
(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 36),
and/or miRBase,
Genomic Views according to UCSC and Ensembl, Transcription factor binding sites according to SABiosciences)
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Genomic View:
UCSC Golden Path with GeneCards custom track

 Transcription factor binding sites upstream to the YPEL2 gene  

Entrez Gene cytogenetic band: 17q22   Ensembl cytogenetic band:  17q22   HGNC cytogenetic band: 17q23

YPEL2 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)

GeneLoc gene densities for chromosome 17         GeneLoc Exon Structure

GeneLoc location for GC17P054763:     (about GC identifiers)

Start:
54,763,835 bp from pter
End:
54,833,877 bp from pter
Size:
70,043 bases
Orientation:
plus strand
RefSeq DNA sequence:
NC_000017.9  NT_010783.14  
(According to 1UniProtKB, and/or Ensembl, Phosphorylation sites according to 2Phosphosite, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Enzo Life Sciences, Abnova, OriGene and/or, Abcam,
Biochemical Assays by Invitrogen, Millipore, R&D Systems, Cell Signaling Technology, and/or Enzo Life Sciences, Ontologies according to Gene Ontology Consortium 01 Apr 2009 and Entrez Gene, Antibodies by Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Cell Signaling Technology, Abcam, Abnova, and/or Novus Biologicals)
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UniProtKB/Swiss-Prot: YPEL2_HUMAN, Q96QA6 (See protein sequence)
Recommended Name: Protein yippee-like 2  
Size: 119 amino acids; 13577 Da
Subcellular location: Nucleus, nucleolus
Secondary accessions: A0PK16 A2RUG4 Q65ZA0 Q8N3W2

Post-translational modifications:

  • View phosphorylation sites using PhosphoSite2


  • REFSEQ proteins: NP_001005404.1  

    ENSEMBL proteins: 
    ENSP00000312272 


    Human Recombinant Proteins 
    Browse Drug Discovery Central at Invitrogen for human recombinant proteins
    Browse Purified and Recombinant Proteins at Millipore
    Browse Human Recombinant Proteins at Sigma-Aldrich  
    Browse R&D Systems for human recombinant proteins
    Browse recombinant and purified proteins available from Enzo Life Sciences
    Browse Abcam for Recombinant Proteins
    Browse Abnova for Human Recombinant Proteins
                  OriGene Purified Recombinant Human Protein: YPEL2 

    1 Gene Ontology (GO) cellular component term (links to tree view):

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634 nucleus IEA--
    About this table

    Antibodies for YPEL2: 
    Browse Antibodies Central at Invitrogen
    Browse Millipore's Extensive Line of Mono- and Polyclonal Antibodies
    Browse Antibodies at Sigma-Aldrich
    Browse R&D Systems for Antibodies
    Search for antibodies at Abcam and the World's Antibody Gateway (free search engine of over 150 antibody companies)
    Browse Abnova for Monoclonal and Polyclonal Antibodies
    Search Novus for antibodies for YPEL2

    Assays for YPEL2: 
    Browse Invitrogen for biochemical assays
    Browse Kits and Assays available from Millipore
    Browse R&D Systems for biochemical assays
    Browse biochemical assays available from Enzo Life Sciences

    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section

    1 InterPro domain/family:
     IPR004910 Yippee


       GeneDecks  YPEL2 for the domains selected above  
    About GeneDecksing

    Graphical View of Domain Structure for InterPro Entry Q96QA6

    ProtoNet protein and cluster: Q96QA6

    1 Blocks protein family: IPB004910 Yippee-like protein

    UniProtKB/Swiss-Prot: YPEL2_HUMAN, Q96QA6
    Similarity: Belongs to the yippee family

    (According to MGI Jun 06 2009, UniProtKB, IUBMB,and/or Genatlas,
    shRNA from OriGene, Sigma-Aldrich, RNAi from Sigma-Aldrich,
    RNAi Products, Clones, and Q-PCR Products from Invitrogen, Millipore, OriGene, and/or Abnova, siRNAs from Applied Biosystems, SYBR primers from OriGene, Cell-based Assays from Millipore, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
    About This Section

    Inhib.
    RNA:
    Invitrogen RNAi Products for gene knock-down (YPEL2)
    Browse for Gene Knock-down Tools from Millipore
    Browse Abnova for Chimera RNAi Products
                  OriGene 29mer shRNA kit in GFP-retroviral vector: NM_001005404

                  Applied Biosystems Silencer® siRNAs for YPEL2

                  Sigma-Aldrich siRNA and siRNA Panels for YPEL2  
                         Sigma-Aldrich shRNA for YPEL2  
                         Explore Sigma-Aldrich super-pooled esiRNAs  

    Clones:Browse Clone Ranger at Invitrogen for clones
    Browse Clones for the Expression of Recombinant Proteins Available from Millipore
                  OriGene GFP tagged cDNA clone in CMV expression vector: NM_001005404
                                     Myc/DDK tagged cDNA clone in CMV expression vector: NM_001005404
                                     untagged cDNA clone in CMV expression vector: NM_001005404 

    Primers: Browse Quantitative PCR Central at Invitrogen for Q-PCR LUX™ Primers
                  OriGene genome-wide validated SYBR primer pairs: NM_001005404

    (Pathways according to Invitrogen (maps by GeneGo), Millipore, Cell Signaling Technology, Sigma-Aldrich, KEGG and/or UniProtKB,
    Sets of similar genes according to GeneDecks, Proteins Network according to SABiosciences, Interactions according to 1UniProtKB, 2MINT, and/or 3STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
    About This Section


      --
    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, Sigma-Aldrich, Tocris Bioscience, and/or Novoseek and Drugs according to Enzo Life Sciences and/or PharmGKB)
    About This Section

    Browse drugs & compounds from Enzo Life Sciences
    Browse Small Molecules at Sigma-Aldrich

    Browse Tocris compounds for YPEL2

    (GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 219 Homo sapiens; Jun 2 2009) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView,
    non coding RNAs according to RNAdb,
    ESTs according to GeneTide,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from Invitrogen, Millipore, and/or Abnova,
    siRNAs from Applied Biosystems, Sigma-Aldrich,
    shRNA from Sigma-Aldrich, OriGene,
    Tagged/untagged cDNA clones from OriGene,
    Expression Assays from Applied Biosystems)
    About This Section

    Inhib.
    RNA:
    Invitrogen RNAi Products for gene knock-down (YPEL2)
    Browse for Gene Knock-down Tools from Millipore
    Browse Abnova for Chimera RNAi Products
                  OriGene 29mer shRNA kit in GFP-retroviral vector: NM_001005404

                  Sigma-Aldrich siRNA and siRNA Panels for YPEL2  
                         Sigma-Aldrich shRNA for YPEL2  
                         Explore Sigma-Aldrich super-pooled esiRNAs  

    Applied Biosystems Silencer® siRNAs: 

    NM_001005404  

    REFSEQ mRNAs for YPEL2 gene: 

    NM_001005404.3   

    Applied Biosystems TaqMan ® Gene Expression Assays: 

    NM_001005404  

                  OriGene GFP tagged cDNA clone in CMV expression vector: NM_001005404
                                     Myc/DDK tagged cDNA clone in CMV expression vector: NM_001005404
                                     untagged cDNA clone in CMV expression vector: NM_001005404 

    Additional cDNA sequence: 

    AB098736.1 AF305195.1 AK096866.1 BC127924.1 BC132884.1 BC132886.1 

    5 DOTS entries:

    DT.101957097  DT.412172  DT.120930241  DT.40127622  DT.95161422 

    24/102 AceView cDNA sequences (see all 102 ):

    BF448974 AI149779 AA588481 CD673236 N59155 BE042903 AW241652 BU633932 
    AA903218 AA242807 AI208796 BQ272526 AI284077 AI985541 AA983913 AA604677 
    BE858915 AL831930 BM264556 BU783882 CA445996 BF195961 AI128325 AI814795 

    highest scoring ESTs for YPEL2:

    AW005748 AA018664 AA018665 AA046023 AA046075 AA204707 AA242807 AA280716 AA281431 AA287724 

    Unigene Cluster for YPEL2:

    Yippee-like 2 (Drosophila)
    Hs.463613  [show with all ESTs]
    Unigene Representative Sequence: NM_001005404


    GeneLoc Exon Structure

    1 Ensembl transcript including schematic representation:
    ENST00000312655  
    (Experimental results according to 1GeneNote and GNF BioGPS,
    probe sets-to-genes annotations according to 2GeneAnnot , 3GeneTide , Sets of similar genes according to GeneDecks, Electronic Northern calculations according to data from UniGene (Build 219 Homo sapiens), SAGE tags according to CGAP, plus additional links to SOURCE, and/or GNF BioGPS, and/or EXPOLDB, and/or UniProtKB,
    Expression Assays from Applied Biosystems )
    About This Section

    YPEL2 expression in normal and diseased human tissues

     Applied Biosystems TaqMan ® Gene Expression Assays for YPEL2

    1 / 2 / 3

    8 probe-sets matching YPEL2 gene


    Affymetrix
    probe-set
    Array  GeneAnnot data GeneNote data GeneTide data
    # genes Sensitivity Specificity Correlation Length Gb_Accession Consensus Uniqueness Score Rank

    50359_at2, 3 U95-B 1 1.00 1.00 0.57 1.50 AI887904 0.60 1.00 0.82 1

    50225_s_at2, 3 U95-C 1 1.00 1.00 0.87 0.96 AW005748 0.80 1.00 0.91 1

    77492_at2, 3 U95-D 1 1.00 1.00 0.66 0.55 AI149779 0.60 1.00 0.82 1

    229060_at2, 3 U133-B 1 1.00 1.00 -- -- AW005748 0.80 1.00 0.91 1

    227020_at2, 3 U133-B 1 1.00 1.00 -- -- BE502982 0.60 1.00 0.82 1

    1556420_s_at2 U133Plus2 1 1.00 1.00 -- -- -- -- -- -- --

    229060_at2 U133Plus2 1 1.00 1.00 -- -- -- -- -- -- --

    227020_at2 U133Plus2 1 1.00 1.00 -- -- -- -- -- -- --
    About this table
    Data from (Publications) and GNF BioGPS
        About these images
    About these images

    CGAP SAGE TAG: TTACCAAATT

    SOURCE GeneReport for Unigene cluster: Hs.463613

    UniProtKB/Swiss-Prot: YPEL2_HUMAN, Q96QA6
    Tissue specificity: Widely expressed. Detected in fetal and adult kidney, heart, liver, lung and
    skeletal muscle

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD and/or 5MGI Jun 06 2009, with possible further links to Flybase and/or WormBase, Gene Trees according to Ensembl)
    About This Section


    Orthologs for YPEL2 gene from 5/17 species (see all 17 )
    Organism Gene Locus Description Human
    Similarity
    NCBI accessions
    dog
    (Canis familiaris)
    YPEL21   -- yippee-like 2 (Drosophila) 96.64(n)
    100(a)
    610066  XM_847459.1  XP_852552.1 
    cow
    (Bos taurus)
    YPEL21   -- yippee-like 2 (Drosophila) 94.12(n)
    100(a)
    616180  XM_001251637.1  XP_001251638.1 
    mouse
    (Mus musculus)
    Ypel21, 5 115
    yippee-like 2 (Drosophila)1, 5 93.56(n)1
    100(a)1
    778641  NM_001005341.31  NP_001005341.11 
     AB0987415  AK0213875  (see all 13)
    chicken
    (Gallus gallus)
    YPEL21   -- yippee-like 2 (Drosophila) 89.92(n)
    100(a)
    417632  NM_001007847.1  NP_001007848.1 
    zebrafish
    (Danio rerio)
    LOC5618511   -- similar to Protein yippee-like 1 82.35(n)
    97.48(a)
    561851  XM_685254.3  XP_690346.1 
    About this table        Species with no ortholog for YPEL2

    ENSEMBL Gene Tree for YPEL2
    (Paralogs according to 1HomoloGene
    and 2Ensembl, Pseudogenes according to 3Pseudogene.org)
    About This Section

    Paralogs for YPEL2 gene
    YPEL12  YPEL32  YPEL42  YPEL52  

    (According to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, and UniProtKB, Linkage Disequilibrium by HapMap, Genotyping Reagents from Applied Biosystems)
    About This Section


    10/348 NCBI SNPs in YPEL2 are shown (see all 348 )
    (Click for Applied Biosystems TaqMan ® Genotyping Assay)  (see all 95)
    ABGenomic DataTranscription DataAllele Frequencies
    SNP IDValidChr 17 posSequenceRecsAA
    Chg
    TypeMoreRecsAllele
    freq
    PopTotal
    sample
    More
    ------------
    rs14515081,2
    A,C,F,H54832017(-) CAATTC/ACCCCA 1 -- ut316Minor allele frequency- A:0.31MN EA EU WA 2088
    rs80720041,2
    A,C,F,H54763354(+) GGTAAC/TTTAGG 1 -- ng518Minor allele frequency- T:0.29EU EA WA 832
    rs14515071,2
    A,C,F54832055(-) CTCCCC/AACACC 1 -- ut312Minor allele frequency- A:0.25MN EA 1686
    rs99055001,2
    A,C54830678(+) TCCAAA/GCATCC 1 -- ut31 ese30--------
    rs7583791,2
    C,F54832398(+) TGTGCA/GAAAGA 1 -- ut31 ese35Minor allele frequency- G:0.30MN NA EA 546
    rs72211851,2
    A,C54831435(+) TGGACC/TCTTTC 1 -- ut31 ese3 trp30--------
    rs72203731,2
    A,C54832851(+) AATTTC/GCAACA 1 -- ut310--------
    rs108530121,2
    A,C54833058(+) TTGAGA/TATGGA 1 -- ut31 ese30--------
    rs126018691,2
    C54831670(+) TTCTGA/CATGTT 1 -- ut310--------
    rs10460371,2
    F54833035(+) AGCAGA/CACCCA 1 -- ut31 ese31Minor allele frequency- C:0.28MN 184
    About this table

    HapMap Linkage Disequilibrium images for YPEL2 (up to first 250kb)

    (in which this Gene is Involved, According to OMIM, UniProtKB, PharmGKB, Genatlas, GeneTests, Blood group antigen gene mutations by BGMUT, HGMD, GAD, HuGE Navigator, BCGD, and/or TGDB.)
    About This Section

    OMIM: 609723

    Human Genome Epidemiology Navigator: YPEL2 (2 documents)

    (Possibly Related Articles in Doctor's Guide)
    About This Section

      --

    (in PubMed. Associations of this gene to articles via 1Novoseek, 2HGNC, 3Entrez Gene, 4UniProtKB/Swiss-Prot, 5UniProtKB/TrEMBL, 6GAD, and/or 7PharmGKB)
    About This Section

    5 PubMed articles for YPEL2 gene:
    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section

     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)
    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, and/or H-InvDB)
    About This Section

    Entrez Gene: 388403 HGNC: 18326 AceView: YPEL2 Ensembl:ENSG00000175155 euGenes: HUgn388403
    ECgene: YPEL2 H-InvDB: YPEL2
    (According to HUGE)
    About This Section

      --
    (According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section

      --
    (Available from WIS Yeda, Salk, Tufts)
    About This Section

      --
    (Reagents available from Applied Biosystems, Antibodies and assays by Cell Signaling Technology, Abcam, Novus Biologicals,
    Sigma-Aldrich, R&D Systems, Millipore, Abnova, and/or Invitrogen, Clones available from OriGene,and/or Invitrogen, Drugs and/or compounds by Sigma-Aldrich,
    Enzo Life Sciences, and/or Tocris Bioscience)
    About This Section



    Products for YPEL2:
     TaqMan ® Gene Expression Assays
     TaqMan ® Genotyping Assays
      Free SNP selection tool



      Invitrogen iPath Pathways  Invitrogen BLOCK-iT™ RNAi
      Invitrogen Antibodies  Invitrogen Assays
      Invitrogen Clones  Invitrogen Q-PCR Products
      Invitrogen Human Recombinant Kinases  Invitrogen Custom Antibody and Peptide Service
      Invitrogen Proteins / Assays / Screening Services  Search Invitrogen catalog for YPEL2-related products

     Millipore Custom Antibody & Bulk Services
     Millipore Preclinical / Clinical Development Services
     Millipore Immunoassay Services
     Millipore Target Screening & Profiling Services


     Predesigned and custom siRNAs for YPEL2 Browse antibodies at Sigma-Aldrich
     Explore super-pooled esiRNAs Browse proteins at Sigma-Aldrich
     Lentivirus-delivered shRNAs for YPEL2 Browse small molecules at Sigma-Aldrich
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     Search Tocris compounds for YPEL2




     Search www.enzolifesicences.com for proteins, assays, substrates, inhibitors & antibodies
     Search Novus for antibodies for YPEL2

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