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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

YPEL2 Gene

protein-coding   GIFtS: 46
GCID: GC17P057409

yippee-like 2 (Drosophila)

 Explore 5 diseases affiliated with
YPEL2 via our new
 Human Malady Compendium 
Biological research products
for YPEL2
    

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, and/or 10fRNAdb)
About This Section

Aliases
Yippee-Like 2 (Drosophila)1 2
FKSG41
DiGeorge Syndrome-Related Protein2
Protein Yippee-Like 22

External Ids:    HGNC: 183261   Entrez Gene: 3884032   Ensembl: ENSG000001751557   OMIM: 6097235   UniProtKB: Q96QA63   

Export aliases for YPEL2 gene to outside databases

Previous GC identifers: GC17P057883 GC17P054763 GC17P052768


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

  --

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000017.10  NC_018928.1  NT_010783.15  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the YPEL2 gene promoter:
         AML1a   NF-kappaB2   Zic1   ATF-2   NF-kappaB   NF-kappaB1   Evi-1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidYPEL2 promoter sequence
   Search SABiosciences Chromatin IP Primers for YPEL2

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat YPEL2


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 17q22   Ensembl cytogenetic band:  17q22   HGNC cytogenetic band: 17q23

YPEL2 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
YPEL2 gene location

GeneLoc information about chromosome 17         GeneLoc Exon Structure

GeneLoc location for GC17P057409:  view genomic region     (about GC identifiers)

Start:
57,409,050 bp from pter      End:
57,479,095 bp from pter
Size:
70,046 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section

UniProtKB/Swiss-Prot: YPEL2_HUMAN, Q96QA6 (See protein sequence)
Recommended Name: Protein yippee-like 2  
Size: 119 amino acids; 13577 Da
Subunit: May interact with FAM168B
Subcellular location: Nucleus, nucleolus
Secondary accessions: A0PK16 A2RUG4 Q65ZA0 Q8N3W2

Explore the universe of human proteins at neXtProt for YPEL2: NX_Q96QA6

Post-translational modifications:

  • View modification sites using PhosphoSitePlus2
  • View neXtProt modification sites for NX_Q96QA6

  • YPEL2 Protein expression data from MOPED and PaxDb:    About this image 
    Estimated protein expression log10 (pmol).

    REFSEQ proteins: NP_001005404.1  
    ENSEMBL proteins: 
     ENSP00000312272   ENSP00000464285  

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    Gene Ontology (GO): 1 cellular component term (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005730nucleolus IEA--


    YPEL2 for ontologies           About GeneDecksing



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    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section

    YPEL2 for domains           About GeneDecksing

    1 InterPro domain/family:
     IPR004910 Yippee

    Graphical View of Domain Structure for InterPro Entry Q96QA6

    ProtoNet protein and cluster: Q96QA6

    1 Blocks protein family: IPB004910 Yippee-like protein

    UniProtKB/Swiss-Prot: YPEL2_HUMAN, Q96QA6
    Similarity: Belongs to the yippee family


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
    About This Section

    miRNA
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    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
    About This Section



    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for YPEL2

    2 Interacting proteins for YPEL2 (Q96QA62, 3) via UniProtKB, MINT, STRING, and/or I2D
    InteractantInteraction Details
    GeneCardExternal ID(s)
    KLC1Q078663I2D: score=5 
    --D4AEP32MINT-8383595
    About this table

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for YPEL2
    Search CenterWatch for drugs/clinical trials and news about YPEL2 

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
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    About This Section

    REFSEQ mRNAs for YPEL2 gene: 
    NM_001005404.3  

    Unigene Cluster for YPEL2:

    Yippee-like 2 (Drosophila)
    Hs.463613  [show with all ESTs]
    Unigene Representative Sequence: NM_001005404
    5 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000581865 ENST00000312655(uc002ixm.1) ENST00000582192(uc002ixl.1)
    ENST00000585166 ENST00000582813

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    hsa-miR-124* hsa-miR-520e hsa-miR-631 hsa-miR-106a hsa-miR-128 hsa-miR-30d hsa-miR-3653 hsa-miR-371-5p
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    Additional cDNA sequence: 

    AB098736.1 AF305195.1 AK096866.1 BC127924.1 BC132884.1 BC132886.1 

    5 DOTS entries:

    DT.101957097  DT.412172  DT.120930241  DT.40127622  DT.95161422 

    24/102 AceView cDNA sequences (see all 102):

    BF448974 AW241652 AA242807 AI149779 AI208796 AI128325 AL831930 BE858915 
    N59155 AI985541 CD673236 AA604677 BU783882 CA445996 AA983913 BU633932 
    BE042903 BF195961 AI814795 BQ272526 AA903218 AA588481 BM264556 AI284077 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    YPEL2 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS
    CGAP TAG: TTACCAAATT

    Microarray
    RNAseq (Illumina Body Map)
    (100×FPKM)½
    SAGE (Serial Analysis of Gene Expression)

    About this image

    YPEL2 expression in embryonic tissues and stem cells
    Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine    About this table
    2 LifeMap In Vivo Development Anatomical Compartments/Cells 
    Tissue Anatomical Compartment CellCategory (developmental path)
    BrainThalamusBrain
    Neural TubeTelencephalonNeural Tube
    Expression: Positive    Negative     Selective marker
    Experimental details: Curated     Microarrays     In-situ hybridization

    See YPEL2 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for YPEL2

    SOURCE GeneReport for Unigene cluster: Hs.463613

    UniProtKB/Swiss-Prot: YPEL2_HUMAN, Q96QA6
    Tissue specificity: Widely expressed. Detected in fetal and adult kidney, heart, liver, lung and skeletal muscle

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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for YPEL2

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of eukaryotes.

    Orthologs for YPEL2 gene from 7/23 species (see all 23)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    chicken
    (Gallus gallus)
    Aves YPEL21 yippee-like 2 (Drosophila) 89.92(n)
    100(a)
      417632  NM_001007847.1  NP_001007848.1 
    lizard
    (Anolis carolinensis)
    Reptilia YPEL26
    --
    65(a)
    1 ↔ 1
    GL344048.1(72332-81314)
    zebrafish
    (Danio rerio)
    Actinopterygii LOC5618511 protein yippee-like 2-like 82.35(n)
    97.48(a)
      561851  XM_685254.3  XP_690346.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta CG153091 CG15309 72.92(n)
    88.39(a)
      31949  NM_001103466.2  NP_001096936.1 
    worm
    (Caenorhabditis elegans)
    Secernentea F37A8.51 Protein F37A8.5 70.18(n)
    86.84(a)
      175512  NM_065395.1  NP_497796.1 
    thale cress
    (Arabidopsis thaliana)
    eudicotyledons AT5G539401 yippee-like zinc-binding protein 58.42(n)
    51.55(a)
      835477  NM_124773.2  NP_200205.1 
    rice
    (Oryza sativa)
    Liliopsida --
    --
    (see all 5)
    yippee zinc-binding protein, putative, expressed
    (see all 5)
    57(a)
    54(a)
    (see all 5)
    many ↔ many
    possible ortholog
    (see all 5)
    11(20052277-20054046)
    3(4853970-4856536)


    ENSEMBL Gene Tree for YPEL2 (if available)
    TreeFam Gene Tree for YPEL2 (if available) 

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for YPEL2 gene
    YPEL32  YPEL12  YPEL42  YPEL52  
    4 SIMAP similar genes for YPEL2 using alignment to 1 protein entry:     YPEL2_HUMAN:
    YPEL1    YPEL4    YPEL3    YPEL5

    YPEL2 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/1235 NCBI SNPs in YPEL2 are shown (see all 1235    About this table
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 17 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1859846001,2
    C,unknown57416613(+) AATGGA/C/TATGAA 1 -- int10--------
    rs1903337941,2
    --57407184(+) CAGAAA/GCAGTA 1 -- us2k10--------
    rs1382507251,2
    --57407200(+) CAGTCC/TTGTTA 1 -- us2k10--------
    rs1828473791,2
    --57407401(+) TAAACC/TGTGGA 1 -- us2k10--------
    rs1427527311,2
    --57407484(+) CTAAAG/TAATCC 1 -- us2k10--------
    rs1871761171,2
    --57407548(+) CTCATC/GTGAAA 1 -- us2k10--------
    rs286876001,2
    C,F,H--57407559(+) GCATTC/TCCCCC 1 -- us2k1 tfbs3 trp37Minor allele frequency- T:0.03NS NA WA CSA 668
    rs1461671021,2
    --57407567(+) CCCCCC/GCCCCC 1 -- us2k10--------
    rs1487845261,2
    --57408017(+) GTCCTA/GTTTTC 1 -- us2k10--------
    rs80720041,2
    C,F,A,H,--57408572(+) GGTAAC/TTTAGG 1 -- us2k120Minor allele frequency- T:0.27NS EA NA 2642

    HapMap Linkage Disequilibrium report for YPEL2 (57409050 - 57479095 bp)
    Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
    Database of Genomic Variants (DGV): 2 variations for YPEL2
         1 CNV: 4043
         1 Indel: 60240

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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section

    YPEL2 for disorders           About GeneDecksing

    OMIM gene information: 609723    OMIM disorders: --

    5 diseases for YPEL2:    About MalaCards
    digeorge syndrome    pancreatic cancer    breast cancer    pancreatitis
    malaria

    Human Genome Epidemiology (HuGE) Navigator: YPEL2 (4 documents)

    Export disorders for YPEL2 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for YPEL2 gene integrated from 9 sources:
    (articles sorted by number of sources associating them with YPEL2)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Identification and characterization of a novel gene family YPEL in a wide spectrum of eukaryotic species. (PubMed id 15556292)1, 2 Hosono K.... Shimizu N. (2004)
    2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    3. Characterizing the neurite outgrowth inhibitory effect of Mani. (PubMed id 22771904)2 Mishra M.... Heese K. (2012)
    4. Centrosome-related genes, genetic variation, and risk of breast cancer. (PubMed id 20508983)1 Olson J.E....Couch F.J. (2010)
    5. Association of mitotic regulation pathway polymorphis ms with pancreatic cancer risk and outcome. (PubMed id 20056645)1 Couch F.J....McWilliams R.R. (2010)
    6. Distinct genetic loci control plasma HIV-RNA and cellular HIV-DNA levels in HIV-1 infection: the ANRS Genome Wide Association 01 study. (PubMed id 19107206)1 Dalmasso C....Theodorou I. (2008)
    7. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1 Ota T.... Sugano S. (2004)
    8. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (2002)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 388403 HGNC: 18326 AceView: YPEL2 Ensembl:ENSG00000175155 euGenes: HUgn388403
    ECgene: YPEL2 H-InvDB: YPEL2

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for YPEL2 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for YPEL2 gene:
    Search GeneIP for patents involving YPEL2

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences),
    In Situ Hybridization Assays from
    Advanced Cell Diagnostics
    About This Section

     
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     YPEL2 Proteins, Antibodies, CLIAs, and ELISAs
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    GeneCards Homepage - Last full update: 19 Mar 2013 - Incrementals: 21 Mar 2013 , 15 Apr 2013 , 26 Apr 2013

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    VWF
    (GIFTS: 73)
    von Willebrand factor
    GIFtS Group
    The GeneCards human gene database gene index: 1 3 5 6 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z 


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