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Aliases for YPEL2 Gene

Aliases for YPEL2 Gene

  • Yippee Like 2 2 3 5
  • DiGeorge Syndrome-Related Protein 3
  • Yippee-Like 2 (Drosophila) 2
  • Yippee-Like 2 3
  • FKSG4 3

External Ids for YPEL2 Gene

Previous GeneCards Identifiers for YPEL2 Gene

  • GC17P057883
  • GC17P054763
  • GC17P057409
  • GC17P052768

Summaries for YPEL2 Gene

GeneCards Summary for YPEL2 Gene

YPEL2 (Yippee Like 2) is a Protein Coding gene. An important paralog of this gene is YPEL5.

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for YPEL2 Gene

Genomics for YPEL2 Gene

Regulatory Elements for YPEL2 Gene

Enhancers for YPEL2 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around YPEL2 on UCSC Golden Path with GeneCards custom track

Promoters for YPEL2 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around YPEL2 on UCSC Golden Path with GeneCards custom track

Genomic Location for YPEL2 Gene

59,331,689 bp from pter
59,401,734 bp from pter
70,046 bases
Plus strand

Genomic View for YPEL2 Gene

Genes around YPEL2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
YPEL2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for YPEL2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for YPEL2 Gene

Proteins for YPEL2 Gene

  • Protein details for YPEL2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Protein yippee-like 2
    Protein Accession:
    Secondary Accessions:
    • A0PK16
    • A2RUG4
    • Q65ZA0
    • Q8N3W2

    Protein attributes for YPEL2 Gene

    119 amino acids
    Molecular mass:
    13577 Da
    Quaternary structure:
    • May interact with FAM168B.

neXtProt entry for YPEL2 Gene

Proteomics data for YPEL2 Gene at MOPED

Post-translational modifications for YPEL2 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for YPEL2 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for YPEL2 Gene

Domains & Families for YPEL2 Gene

Gene Families for YPEL2 Gene

Protein Domains for YPEL2 Gene


Suggested Antigen Peptide Sequences for YPEL2 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Contains 1 Yippee domain.
  • Belongs to the yippee family.
  • Contains 1 Yippee domain.
  • Belongs to the yippee family.
genes like me logo Genes that share domains with YPEL2: view

Function for YPEL2 Gene

genes like me logo Genes that share phenotypes with YPEL2: view

Animal Model Products

  • Taconic Biosciences Mouse Models for YPEL2

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for YPEL2 Gene

Localization for YPEL2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for YPEL2 Gene

Nucleus, nucleolus.

Subcellular locations from

Jensen Localization Image for YPEL2 Gene COMPARTMENTS Subcellular localization image for YPEL2 gene
Compartment Confidence
nucleus 4
extracellular 2
mitochondrion 2
cytosol 1

No data available for Gene Ontology (GO) - Cellular Components for YPEL2 Gene

Pathways & Interactions for YPEL2 Gene

SuperPathways for YPEL2 Gene

No Data Available

Interacting Proteins for YPEL2 Gene

Gene Ontology (GO) - Biological Process for YPEL2 Gene


No data available for Pathways by source and SIGNOR curated interactions for YPEL2 Gene

Drugs & Compounds for YPEL2 Gene

No Compound Related Data Available

Transcripts for YPEL2 Gene

Unigene Clusters for YPEL2 Gene

Yippee-like 2 (Drosophila):
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for YPEL2 Gene

No ASD Table

Relevant External Links for YPEL2 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for YPEL2 Gene

mRNA expression in normal human tissues for YPEL2 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

SOURCE GeneReport for Unigene cluster for YPEL2 Gene Hs.463613

mRNA Expression by UniProt/SwissProt for YPEL2 Gene

Tissue specificity: Widely expressed. Detected in fetal and adult kidney, heart, liver, lung and skeletal muscle.
genes like me logo Genes that share expression patterns with YPEL2: view

Primer Products

No data available for mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression and Protein tissue co-expression partners for YPEL2 Gene

Orthologs for YPEL2 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for YPEL2 Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia YPEL2 35
  • 94.12 (n)
  • 100 (a)
YPEL2 36
  • 100 (a)
(Canis familiaris)
Mammalia YPEL2 35
  • 96.64 (n)
  • 100 (a)
YPEL2 36
  • 100 (a)
(Mus musculus)
Mammalia Ypel2 35
  • 93.56 (n)
  • 100 (a)
Ypel2 16
Ypel2 36
  • 100 (a)
(Pan troglodytes)
Mammalia YPEL2 35
  • 99.72 (n)
  • 100 (a)
YPEL2 36
  • 100 (a)
(Monodelphis domestica)
Mammalia YPEL2 36
  • 36 (a)
(Ornithorhynchus anatinus)
Mammalia YPEL2 36
  • 98 (a)
(Gallus gallus)
Aves YPEL2 35
  • 89.92 (n)
  • 100 (a)
YPEL2 36
  • 100 (a)
(Anolis carolinensis)
Reptilia YPEL2 36
  • 62 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia ypel2 35
  • 84.31 (n)
  • 100 (a)
(Danio rerio)
Actinopterygii LOC100004727 35
  • 81.32 (n)
  • 98.28 (a)
ypel2a 36
  • 91 (a)
ypel2b 36
  • 97 (a)
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP011563 35
  • 73.91 (n)
  • 88.7 (a)
fruit fly
(Drosophila melanogaster)
Insecta CG15309 35
  • 72.92 (n)
  • 88.39 (a)
CG15309 36
  • 89 (a)
(Caenorhabditis elegans)
Secernentea F37A8.5 36
  • 72 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes MOH1 36
  • 36 (a)
thale cress
(Arabidopsis thaliana)
eudicotyledons AT5G53940 35
  • 58.42 (n)
  • 51.55 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 78 (a)
Species with no ortholog for YPEL2:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for YPEL2 Gene

Gene Tree for YPEL2 (if available)
Gene Tree for YPEL2 (if available)

Paralogs for YPEL2 Gene

Paralogs for YPEL2 Gene

(4) SIMAP similar genes for YPEL2 Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with YPEL2: view

Variants for YPEL2 Gene

Sequence variations from dbSNP and Humsavar for YPEL2 Gene

SNP ID Clin Chr 17 pos Sequence Context AA Info Type
rs2520 -- 59,397,614(-) CCACC(A/C)TTCCA utr-variant-3-prime
rs10599 -- 59,397,562(+) CGTGA(A/G)GAAGA utr-variant-3-prime
rs12060 -- 59,397,457(-) AGGAT(A/C)TGTTC utr-variant-3-prime
rs930709 -- 59,345,207(-) ATTCT(C/T)TCAGC intron-variant
rs930710 -- 59,342,637(-) GAGAT(A/G)ATAAT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for YPEL2 Gene

Variant ID Type Subtype PubMed ID
dgv995e1 CNV Complex 17122850
nsv833500 CNV Loss 17160897
nsv908649 CNV Gain 21882294
esv7723 CNV Gain 19470904
nsv527058 CNV Loss 19592680

Variation tolerance for YPEL2 Gene

Residual Variation Intolerance Score: 49.5% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.05; 1.10% of all genes are more intolerant (likely to be disease-causing)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Relevant External Links for YPEL2 Gene

Disorders for YPEL2 Gene

Relevant External Links for YPEL2

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator
Atlas of Genetics and Cytogenetics in Oncology and Haematology:

No disorders were found for YPEL2 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for YPEL2 Gene

Publications for YPEL2 Gene

  1. Identification and characterization of a novel gene family YPEL in a wide spectrum of eukaryotic species. (PMID: 15556292) Hosono K. … Shimizu N. (Gene 2004) 2 3 4 67
  2. Genetic association study of QT interval highlights role for calcium signaling pathways in myocardial repolarization. (PMID: 24952745) Arking D.E. … Newton-Cheh C. (Nat. Genet. 2014) 3
  3. The protein interaction landscape of the human CMGC kinase group. (PMID: 23602568) Varjosalo M. … Gstaiger M. (Cell Rep 2013) 3
  4. Centrosome-related genes, genetic variation, and risk of breast cancer. (PMID: 20508983) Olson J.E. … Couch F.J. (Breast Cancer Res. Treat. 2011) 3
  5. Association of mitotic regulation pathway polymorphisms with pancreatic cancer risk and outcome. (PMID: 20056645) Couch F.J. … McWilliams R.R. (Cancer Epidemiol. Biomarkers Prev. 2010) 3

Products for YPEL2 Gene

Sources for YPEL2 Gene