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Category Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21

GIFtS
-

YPEL2 Gene

protein-coding GIFtS: 46
GCID: GC17P057409

yippee-like 2 (Drosophila)

Explore 5 diseases affiliated with
YPEL2 via

MalaCards

our new
Human Malady Compendium

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc, ⁷Ensembl, ⁸DME, ⁹miRBase, and/or ¹⁰fRNAdb)
About This Section

Aliases
Yippee-Like 2 (Drosophila)¹ ²
FKSG4¹
DiGeorge Syndrome-Related Protein²
Protein Yippee-Like 2²

External Ids:	HGNC: 18326¹	Entrez Gene: 388403²	Ensembl: ENSG00000175155⁷	OMIM: 609723⁵	UniProtKB: Q96QA6³

Export aliases for YPEL2 gene to outside databases

Previous GC identifers: GC17P057883 GC17P054763 GC17P052768

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section

RefSeq DNA sequence:

NC_000017.10 NC_018928.1 NT_010783.15

Regulatory elements:

SABiosciences Regulatory transcription factor binding sites in the YPEL2 gene promoter:
AML1a NF-kappaB2 Zic1 ATF-2 NF-kappaB NF-kappaB1 Evi-1
Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: YPEL2 promoter sequence

Search SABiosciences Chromatin IP Primers for YPEL2

Epigenetics:

QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat YPEL2

Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 17q22 Ensembl cytogenetic band: 17q22 HGNC cytogenetic band: 17q23

YPEL2 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
YPEL2 gene location

GeneLoc information about chromosome 17 GeneLoc Exon Structure

GeneLoc location for GC17P057409: view genomic region (about GC identifiers)

Start:	57,409,050 bp from pter	End:	57,479,095 bp from pter
Size:	70,046 bases	Orientation:	plus strand

(According to ¹UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to ²PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section

UniProtKB/Swiss-Prot: YPEL2_HUMAN, Q96QA6 (See protein sequence)

Recommended Name: Protein yippee-like 2

Size: 119 amino acids; 13577 Da

Subunit: May interact with FAM168B

Subcellular location: Nucleus, nucleolus

Secondary accessions: A0PK16 A2RUG4 Q65ZA0 Q8N3W2

Explore the universe of human proteins at neXtProt for YPEL2: NX_Q96QA6

Post-translational modifications:

View modification sites using PhosphoSitePlus²

View neXtProt modification sites for NX_Q96QA6

YPEL2 Protein expression data from MOPED and PaxDb: About this image

REFSEQ proteins: NP_001005404.1

ENSEMBL proteins:

ENSP00000312272 ENSP00000464285

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Gene Ontology (GO): 1 cellular component term (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005730	nucleolus	IEA	--

YPEL2 for ontologies About GeneDecksing

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(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

YPEL2 for domains About GeneDecksing

1 InterPro domain/family:

IPR004910 Yippee

Graphical View of Domain Structure for InterPro Entry Q96QA6

ProtoNet protein and cluster: Q96QA6

1 Blocks protein family: IPB004910 Yippee-like protein

UniProtKB/Swiss-Prot: YPEL2_HUMAN, Q96QA6

Similarity: Belongs to the yippee family

(According to ¹UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or ²DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
About This Section

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(Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to ¹UniProtKB, ²MINT, ³I2D, and/or ⁴STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
About This Section

Interactions:

Search SABiosciences Gene Network Central^TM Interacting Genes and Proteins Networks for YPEL2

2 Interacting proteins for YPEL2 (Q96QA6^{2, 3}) via UniProtKB, MINT, STRING, and/or I2D

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
KLC1	Q07866³	I2D: score=5
--	D4AEP3²	MINT-8383595

About this table

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
About This Section

Browse Small Molecules at EMD Millipore

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(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
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Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
About This Section

REFSEQ mRNAs for YPEL2 gene:

NM_001005404.3

Unigene Cluster for YPEL2:

Yippee-like 2 (Drosophila)

Hs.463613 [show with all ESTs]

Unigene Representative Sequence: NM_001005404

5 Ensembl transcripts including schematic representations, and UCSC links where relevant:

ENST00000581865 ENST00000312655(uc002ixm.1) ENST00000582192(uc002ixl.1)

ENST00000585166 ENST00000582813

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Additional cDNA sequence:

AB098736.1 AF305195.1 AK096866.1 BC127924.1 BC132884.1 BC132886.1

5 DOTS entries:

DT.101957097 DT.412172 DT.120930241 DT.40127622 DT.95161422

24/102 AceView cDNA sequences (see all 102):

BF448974 AW241652 AA242807 AI149779 AI208796 AI128325 AL831930 BE858915

N59155 AI985541 CD673236 AA604677 BU783882 CA445996 AA983913 BU633932

BE042903 BF195961 AI814795 BQ272526 AA903218 AA588481 BM264556 AI284077

GeneLoc Exon Structure

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section

YPEL2 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: TTACCAAATT

About this image

YPEL2 expression in embryonic tissues and stem cells

Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine About this table

2 LifeMap In Vivo Development Anatomical Compartments/Cells

Tissue

Anatomical Compartment

Cell

Category (developmental path)

Brain

Neural Tube

Expression:

Positive

Negative

Selective marker

Experimental details:

Curated

Microarrays

In-situ hybridization

See YPEL2 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for YPEL2

SOURCE GeneReport for Unigene cluster: Hs.463613

UniProtKB/Swiss-Prot: YPEL2_HUMAN, Q96QA6

Tissue specificity: Widely expressed. Detected in fetal and adult kidney, heart, liver, lung and skeletal muscle

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In Situ
Assay Products:

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(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD , ⁵MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or ⁶Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
About This Section

This gene was present in the common ancestor of eukaryotes.

Orthologs for YPEL2 gene from 7/23 species (see all 23) About this table

Organism	Taxonomic classification	Gene	Description	Human Similarity	Orthology Type	Details
chicken (Gallus gallus)	Aves	YPEL2¹	yippee-like 2 (Drosophila)	89.92(n) 100(a)		417632 NM_001007847.1 NP_001007848.1
lizard (Anolis carolinensis)	Reptilia	YPEL2⁶	--	65(a)	1 ↔ 1	GL344048.1(72332-81314)
zebrafish (Danio rerio)	Actinopterygii	LOC561851¹	protein yippee-like 2-like	82.35(n) 97.48(a)		561851 XM_685254.3 XP_690346.1
fruit fly (Drosophila melanogaster)	Insecta	CG15309¹	CG15309	72.92(n) 88.39(a)		31949 NM_001103466.2 NP_001096936.1
worm (Caenorhabditis elegans)	Secernentea	F37A8.5¹	Protein F37A8.5	70.18(n) 86.84(a)		175512 NM_065395.1 NP_497796.1
thale cress (Arabidopsis thaliana)	eudicotyledons	AT5G53940¹	yippee-like zinc-binding protein	58.42(n) 51.55(a)		835477 NM_124773.2 NP_200205.1
rice (Oryza sativa)	Liliopsida	-- -- (see all 5)	yippee zinc-binding protein, putative, expressed (see all 5)	57(a) 54(a) (see all 5)	many ↔ many possible ortholog (see all 5)	11(20052277-20054046) 3(4853970-4856536)

ENSEMBL Gene Tree for YPEL2 (if available)
TreeFam Gene Tree for YPEL2 (if available)

(Paralogs according to ¹HomoloGene,
²Ensembl, and ³SIMAP, Pseudogenes according to ⁴Pseudogene.org Build 68)
About This Section

Paralogs for YPEL2 gene

YPEL3² YPEL1² YPEL4² YPEL5²

4 SIMAP similar genes for YPEL2 using alignment to 1 protein entry: YPEL2_HUMAN:

YPEL1 YPEL4 YPEL3 YPEL5

YPEL2 for paralogs About GeneDecksing

(SNPs/Variants according to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section

SNP ID	Valid	Clinical significance	Chr 17 pos	Sequence	#	AA Chg	Type	More	#	Allele freq	Pop	Total sample	More
Genomic Data					Transcription Related Data				Allele Frequencies
				--	--	--		--	--
rs185984600^1,2	C,	unknown	57416613(+)	`AATGGA/C/TATGAA`	1	--	int¹		0	--	--	--	--
rs190333794^1,2		--	57407184(+)	`CAGAAA/GCAGTA`	1	--	us2k¹		0	--	--	--	--
rs138250725^1,2		--	57407200(+)	`CAGTCC/TTGTTA`	1	--	us2k¹		0	--	--	--	--
rs182847379^1,2		--	57407401(+)	`TAAACC/TGTGGA`	1	--	us2k¹		0	--	--	--	--
rs142752731^1,2		--	57407484(+)	`CTAAAG/TAATCC`	1	--	us2k¹		0	--	--	--	--
rs187176117^1,2		--	57407548(+)	`CTCATC/GTGAAA`	1	--	us2k¹		0	--	--	--	--
rs28687600^1,2	C,F,H	--	57407559(+)	`GCATTC/TCCCCC`	1	--	us2k¹ tfbs³ trp³		7		NS NA WA CSA	668
rs146167102^1,2		--	57407567(+)	`CCCCCC/GCCCCC`	1	--	us2k¹		0	--	--	--	--
rs148784526^1,2		--	57408017(+)	`GTCCTA/GTTTTC`	1	--	us2k¹		0	--	--	--	--
rs8072004^1,2	C,F,A,H,	--	57408572(+)	`GGTAAC/TTTAGG`	1	--	us2k¹		20		NS EA NA	2642

HapMap Linkage Disequilibrium report for YPEL2 (57409050 - 57479095 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 2 variations for YPEL2
1 CNV: 4043
1 Indel: 60240

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(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
About This Section

YPEL2 for disorders           About GeneDecksing

OMIM gene information: 609723    OMIM disorders: --

5 diseases for YPEL2:    About MalaCards

digeorge syndrome pancreatic cancer breast cancer pancreatitis

malaria

Human Genome Epidemiology (HuGE) Navigator: YPEL2 (4 documents)

Export disorders for YPEL2 gene to outside databases

(in PubMed. Associations of this gene to articles via ¹Entrez Gene, ²UniProtKB/Swiss-Prot, ³HGNC, ⁴GAD, ⁵PharmGKB, ⁶HMDB, ⁷DrugBank, ⁸UniProtKB/TrEMBL, ⁹ Novoseek, and/or ¹⁰fRNAdb)
About This Section

PubMed articles for YPEL2 gene integrated from 9 sources:
(articles sorted by number of sources associating them with YPEL2)

Utopia: connect your pdf to the dynamic
world of online information

Identification and characterization of a novel gene family YPEL in a wide spectrum of eukaryotic species. (PubMed id 15556292)^{1, 2} Hosono K.... Shimizu N. (2004)
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)^{1, 2} Gerhard D.S....Malek J. (2004)
Characterizing the neurite outgrowth inhibitory effect of Mani. (PubMed id 22771904)² Mishra M.... Heese K. (2012)
Centrosome-related genes, genetic variation, and risk of breast cancer. (PubMed id 20508983)¹ Olson J.E....Couch F.J. (2010)
Association of mitotic regulation pathway polymorphis ms with pancreatic cancer risk and outcome. (PubMed id 20056645)¹ Couch F.J....McWilliams R.R. (2010)
Distinct genetic loci control plasma HIV-RNA and cellular HIV-DNA levels in HIV-1 infection: the ANRS Genome Wide Association 01 study. (PubMed id 19107206)¹ Dalmasso C....Theodorou I. (2008)
Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)¹ Ota T.... Sugano S. (2004)
Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)¹ Strausberg R.L....Marra M.A. (2002)

(in PubMed, OMIM, and NCBI Bookshelf)
About This Section

		AND	OR
Aliases
Free Text

Query String		PubMed OMIM NCBI Bookshelf
	(Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
About This Section

Entrez Gene: 388403	HGNC: 18326	AceView: YPEL2	Ensembl:ENSG00000175155	euGenes: HUgn388403
ECgene: YPEL2	H-InvDB: YPEL2

(According to HUGE)
About This Section

(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section

Name	Description
PharmGKB entry for YPEL2	Pharmacogenomics, SNPs, Pathways

Intellectual Property for YPEL2 gene
(Patent information from GeneIP, Licensable technologies from WIS Yeda, Salk, Tufts, IP news from LifeMap Sciences, Inc.)

About This Section

Patent Information for YPEL2 gene:
Search GeneIP for patents involving YPEL2

GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search

(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences),
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About This Section


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GeneCards Homepage - Last full update: 19 Mar 2013 - Incrementals: 21 Mar 2013 , 15 Apr 2013 , 26 Apr 2013

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Category			VWF (GIFTS: 73) von Willebrand factor
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The GeneCards human gene database gene index: 1 3 5 6 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

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Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

Hot genes Disease genes YPEL2 gene at Home site.

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YPEL2 Gene

yippee-like 2 (Drosophila)

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YPEL2 Gene

yippee-like 2 (Drosophila)

Aliasesfor YPEL2 gene

Summariesfor YPEL2 gene

Genomic Viewsfor YPEL2 gene

Proteinsfor YPEL2 gene

Protein Domains /Familiesfor YPEL2 gene

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for YPEL2 gene

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for YPEL2 gene

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for YPEL2 gene

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for YPEL2 gene

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for YPEL2 gene

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for YPEL2 gene

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for YPEL2 gene

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Orthologs
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for YPEL2 gene

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Intellectual Property
for YPEL2 gene

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for YPEL2 gene