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Aliases for YPEL2 Gene

Aliases for YPEL2 Gene

  • Yippee Like 2 2 3 5
  • DiGeorge Syndrome-Related Protein 3
  • Yippee-Like 2 (Drosophila) 2
  • Protein Yippee-Like 2 3
  • FKSG4 3

External Ids for YPEL2 Gene

Previous GeneCards Identifiers for YPEL2 Gene

  • GC17P057883
  • GC17P054763
  • GC17P057409
  • GC17P052768

Summaries for YPEL2 Gene

GeneCards Summary for YPEL2 Gene

YPEL2 (Yippee Like 2) is a Protein Coding gene. An important paralog of this gene is YPEL1.

Additional gene information for YPEL2 Gene

No data available for Entrez Gene Summary , CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for YPEL2 Gene

Genomics for YPEL2 Gene

GeneHancer (GH) Regulatory Elements for YPEL2 Gene

Promoters and enhancers for YPEL2 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH17I059327 Promoter/Enhancer 2.8 EPDnew FANTOM5 Ensembl ENCODE dbSUPER 556.2 -1.1 -1130 6 PKNOX1 CLOCK FOXA2 ARID4B SIN3A DMAP1 ZBTB7B YY1 ZNF207 ZNF143 YPEL2 RNFT1 NDUFB8P2 RPS6KB1 TUBD1 HEATR6 TEX14 SKA2 SNRPGP17
GH17I059364 Enhancer 1.7 FANTOM5 Ensembl ENCODE dbSUPER 14.4 +39.0 39011 11.8 PKNOX1 CLOCK SMAD1 FOXA2 MLX ARNT ZFP64 ARID4B SIN3A FEZF1 YPEL2 DHX40 SKA2 RPS6KB1 MIR4729 ENSG00000266002
GH17I059438 Enhancer 1.6 FANTOM5 Ensembl ENCODE dbSUPER 14.9 +108.7 108721 3.3 HDGF PKNOX1 SMAD1 ATF1 ARID4B SIN3A IRF4 SLC30A9 ARID2 ZNF143 YPEL2 SMG8 MIR454 GC17P059454 ENSG00000266002 LINC01476
GH17I059422 Enhancer 1.6 FANTOM5 Ensembl ENCODE dbSUPER 14 +94.0 93951 6.4 PKNOX1 ZNF766 FOS ATF7 REST ZNF592 MEF2D MAFF SMARCA4 GLIS1 TUBD1 YPEL2 RPS6KB1 HEATR6 SMG8 TEX14 TRIM37 ENSG00000266002 GC17P059454
GH17I059434 Enhancer 1.5 FANTOM5 Ensembl ENCODE dbSUPER 13.6 +103.7 103741 1.1 PKNOX1 RAD21 RFX5 ZNF366 FOS CEBPB GATAD2B REST ELF1 MAFF YPEL2 GC17P059454 ENSG00000266002 LINC01476
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around YPEL2 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the YPEL2 gene promoter:

Genomic Locations for YPEL2 Gene

Genomic Locations for YPEL2 Gene
chr17:59,331,689-59,401,734
(GRCh38/hg38)
Size:
70,046 bases
Orientation:
Plus strand
chr17:57,409,050-57,479,095
(GRCh37/hg19)

Genomic View for YPEL2 Gene

Genes around YPEL2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
YPEL2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for YPEL2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for YPEL2 Gene

Proteins for YPEL2 Gene

  • Protein details for YPEL2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q96QA6-YPEL2_HUMAN
    Recommended name:
    Protein yippee-like 2
    Protein Accession:
    Q96QA6
    Secondary Accessions:
    • A0PK16
    • A2RUG4
    • Q65ZA0
    • Q8N3W2

    Protein attributes for YPEL2 Gene

    Size:
    119 amino acids
    Molecular mass:
    13577 Da
    Quaternary structure:
    • May interact with FAM168B.

neXtProt entry for YPEL2 Gene

Post-translational modifications for YPEL2 Gene

No Post-translational modifications

Other Protein References for YPEL2 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for YPEL2 Gene

Domains & Families for YPEL2 Gene

Gene Families for YPEL2 Gene

HGNC:
Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Protein Domains for YPEL2 Gene

Suggested Antigen Peptide Sequences for YPEL2 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q96QA6

UniProtKB/Swiss-Prot:

YPEL2_HUMAN :
  • Belongs to the yippee family.
Family:
  • Belongs to the yippee family.
genes like me logo Genes that share domains with YPEL2: view

Function for YPEL2 Gene

Phenotypes From GWAS Catalog for YPEL2 Gene

Gene Ontology (GO) - Molecular Function for YPEL2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0046872 metal ion binding IEA --
genes like me logo Genes that share ontologies with YPEL2: view
genes like me logo Genes that share phenotypes with YPEL2: view

Clone Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for YPEL2 Gene

Localization for YPEL2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for YPEL2 Gene

Nucleus, nucleolus.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for YPEL2 gene
Compartment Confidence
nucleus 4
extracellular 2
mitochondrion 2
cytosol 1

Gene Ontology (GO) - Cellular Components for YPEL2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005730 nucleolus IEA --
genes like me logo Genes that share ontologies with YPEL2: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for YPEL2 Gene

Pathways & Interactions for YPEL2 Gene

SuperPathways for YPEL2 Gene

No Data Available

Gene Ontology (GO) - Biological Process for YPEL2 Gene

None

No data available for Pathways by source and SIGNOR curated interactions for YPEL2 Gene

Drugs & Compounds for YPEL2 Gene

No Compound Related Data Available

Transcripts for YPEL2 Gene

Unigene Clusters for YPEL2 Gene

Yippee-like 2 (Drosophila):
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for YPEL2 Gene

No ASD Table

Relevant External Links for YPEL2 Gene

GeneLoc Exon Structure for
YPEL2
ECgene alternative splicing isoforms for
YPEL2

Expression for YPEL2 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for YPEL2 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

NURSA nuclear receptor signaling pathways regulating expression of YPEL2 Gene:

YPEL2

SOURCE GeneReport for Unigene cluster for YPEL2 Gene:

Hs.463613

mRNA Expression by UniProt/SwissProt for YPEL2 Gene:

Q96QA6-YPEL2_HUMAN
Tissue specificity: Widely expressed. Detected in fetal and adult kidney, heart, liver, lung and skeletal muscle.

Evidence on tissue expression from TISSUES for YPEL2 Gene

  • Lung(4.3)
genes like me logo Genes that share expression patterns with YPEL2: view

No data available for mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners and Phenotype-based relationships between genes and organs from Gene ORGANizer for YPEL2 Gene

Orthologs for YPEL2 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for YPEL2 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia YPEL2 33 34
  • 99.72 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia YPEL2 34
  • 98 (a)
OneToOne
dog
(Canis familiaris)
Mammalia YPEL2 33 34
  • 96.64 (n)
cow
(Bos Taurus)
Mammalia YPEL2 33 34
  • 94.12 (n)
mouse
(Mus musculus)
Mammalia Ypel2 33 16 34
  • 93.56 (n)
oppossum
(Monodelphis domestica)
Mammalia YPEL2 34
  • 36 (a)
OneToOne
chicken
(Gallus gallus)
Aves YPEL2 33 34
  • 89.92 (n)
lizard
(Anolis carolinensis)
Reptilia YPEL2 34
  • 62 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia ypel2 33
  • 84.31 (n)
zebrafish
(Danio rerio)
Actinopterygii ypel2b 34
  • 97 (a)
OneToMany
ypel2a 34
  • 91 (a)
OneToMany
LOC100004727 33
  • 81.32 (n)
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP011563 33
  • 73.91 (n)
fruit fly
(Drosophila melanogaster)
Insecta CG15309 33 34
  • 72.92 (n)
worm
(Caenorhabditis elegans)
Secernentea F37A8.5 34
  • 72 (a)
OneToMany
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes MOH1 34
  • 36 (a)
OneToMany
thale cress
(Arabidopsis thaliana)
eudicotyledons AT5G53940 33
  • 58.42 (n)
sea squirt
(Ciona savignyi)
Ascidiacea -- 34
  • 78 (a)
OneToMany
Species where no ortholog for YPEL2 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for YPEL2 Gene

ENSEMBL:
Gene Tree for YPEL2 (if available)
TreeFam:
Gene Tree for YPEL2 (if available)

Paralogs for YPEL2 Gene

Paralogs for YPEL2 Gene

(4) SIMAP similar genes for YPEL2 Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with YPEL2: view

Variants for YPEL2 Gene

Sequence variations from dbSNP and Humsavar for YPEL2 Gene

SNP ID Clin Chr 17 pos Variation AA Info Type
rs1000037500 -- 59,332,237(+) C/T genic_upstream_transcript_variant, intron_variant, upstream_transcript_variant
rs1000040539 -- 59,377,983(+) A/G intron_variant
rs1000054745 -- 59,391,940(+) G/A intron_variant
rs1000070867 -- 59,400,726(+) G/A 3_prime_UTR_variant
rs1000084767 -- 59,376,449(+) C/A intron_variant

Structural Variations from Database of Genomic Variants (DGV) for YPEL2 Gene

Variant ID Type Subtype PubMed ID
esv2758699 CNV gain 17122850
esv3573764 CNV gain 25503493
esv3582851 CNV loss 25503493
esv7723 CNV gain 19470904
nsv1057152 CNV gain 25217958
nsv1062736 CNV gain 25217958
nsv1109094 CNV deletion 24896259
nsv527058 CNV loss 19592680
nsv833500 CNV loss 17160897

Variation tolerance for YPEL2 Gene

Residual Variation Intolerance Score: 49.5% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.05; 1.10% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for YPEL2 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
YPEL2

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for YPEL2 Gene

Disorders for YPEL2 Gene

Additional Disease Information for YPEL2

Genetic Association Database
(GAD)
Human Genome Epidemiology Navigator
(HuGE)
ATLAS of Genetics and Cytogenetics in Oncology and Haematology

No disorders were found for YPEL2 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for YPEL2 Gene

Publications for YPEL2 Gene

  1. Identification and characterization of a novel gene family YPEL in a wide spectrum of eukaryotic species. (PMID: 15556292) Hosono K … Shimizu N (Gene 2004) 2 3 4 58
  2. Centrosome-related genes, genetic variation, and risk of breast cancer. (PMID: 20508983) Olson JE … Couch FJ (Breast cancer research and treatment 2011) 3 44 58
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 58
  4. Genetic association study of QT interval highlights role for calcium signaling pathways in myocardial repolarization. (PMID: 24952745) Arking DE … Newton-Cheh C (Nature genetics 2014) 3 58
  5. The protein interaction landscape of the human CMGC kinase group. (PMID: 23602568) Varjosalo M … Gstaiger M (Cell reports 2013) 3 58

Products for YPEL2 Gene

Sources for YPEL2 Gene

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