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YPEL1 Gene

protein-coding GIFtS: 50

GC22M020381

yippee-like 1 (Drosophila)
(Previous name: yippee (Drosophila) homolog-like 1 )
Symbol approved by the HUGO Gene Nomenclature Committee (HGNC) database

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc , and/or ⁷Ensembl, ⁸miRBase)
About This Section

Aliases
FKSG3 ^²
MGC64992 ^²

Descriptions
DiGeorge syndrome-related protein ^²
yippee (Drosophila) homolog-like 1 ^¹
yippee-like 1 ^²
yippee-like 1 (Drosophila) ^²

External Ids
HGNC: 12845¹
Entrez Gene: 29799²
UniProtKB: O60688³
Ensembl: ENSG00000100027⁷

Search outside databases for aliases for YPEL1 gene

Previous GC identifers: GC22M018753 GC22M020379 GC22M020377

(According to Entrez Gene, Wikipedia's Gene Wiki,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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EntrezGene summary for YPEL1:

This gene encodes a potential zinc-binding protein and is located in the region associated with

DiGeorge syndrome on chromosome 22. The encoded protein may play a role in the regulation of

cellular morphology and may function during craniofacial development. [provided by RefSeq]

UniProtKB/Swiss-Prot: YPEL1_HUMAN, O60688

Function: May play a role in epithelioid conversion of fibroblasts

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 36),
and/or miRBase,
Genomic Views according to UCSC and Ensembl, Transcription factor binding sites according to SABiosciences)
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Genomic View:

UCSC Golden Path with GeneCards custom track

Transcription factor binding sites upstream to the YPEL1 gene

Entrez Gene cytogenetic band: 22q11.2 Ensembl cytogenetic band: 22q11.21 HGNC cytogenetic band: 22q11.2

YPEL1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)

GeneLoc gene densities for chromosome 22 GeneLoc Exon Structure

GeneLoc location for GC22M020381: (about GC identifiers)

Start:	20,381,825 bp from pter
End:	20,420,071 bp from pter
Size:	38,247 bases
Orientation:	minus strand

RefSeq DNA sequence:

NC_000022.9 NT_011520.11

(According to ¹UniProtKB, and/or Ensembl, Phosphorylation sites according to ²Phosphosite, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Enzo Life Sciences, Abnova, OriGene and/or, Abcam,
Biochemical Assays by Invitrogen, Millipore, R&D Systems, Cell Signaling Technology, and/or Enzo Life Sciences, Ontologies according to Gene Ontology Consortium 01 Apr 2009 and Entrez Gene, Antibodies by Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Cell Signaling Technology, Abcam, Abnova, and/or Novus Biologicals)
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UniProtKB/Swiss-Prot: YPEL1_HUMAN, O60688 (See protein sequence)

Recommended Name: Protein yippee-like 1

Size: 119 amino acids; 13575 Da

Subcellular location: Nucleus (By similarity)

Secondary accessions: Q65ZA1 Q6GLI6

REFSEQ proteins: NP_037445.1

ENSEMBL proteins:

ENSP00000342832 ENSP00000386014

Human Recombinant Proteins

	Browse Drug Discovery Central at Invitrogen for human recombinant proteins
	Browse Purified and Recombinant Proteins at Millipore
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	Browse Abnova for Human Recombinant Proteins

OriGene Purified Recombinant Human Protein: YPEL1

1 Gene Ontology (GO) cellular component term (links to tree view):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005634	nucleus	IEA	--

About this table

Antibodies for YPEL1:

	Browse Antibodies Central at Invitrogen
	Browse Millipore's Extensive Line of Mono- and Polyclonal Antibodies
	Browse Antibodies at Sigma-Aldrich
	Browse R&D Systems for Antibodies
	Search for antibodies at Abcam and the World's Antibody Gateway (free search engine of over 150 antibody companies)
	Browse Abnova for Monoclonal and Polyclonal Antibodies
	Search Novus for antibodies for YPEL1

Assays for YPEL1:

	Browse Invitrogen for biochemical assays
	Browse Kits and Assays available from Millipore
	Browse R&D Systems for biochemical assays
	Browse biochemical assays available from Enzo Life Sciences

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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Graphical View of Domain Structure for InterPro Entry O60688

ProtoNet protein and cluster: O60688

1 Blocks protein family: IPB004910 Yippee-like protein

UniProtKB/Swiss-Prot: YPEL1_HUMAN, O60688

Similarity: Belongs to the yippee family

(According to MGI Jun 06 2009, UniProtKB, IUBMB,and/or Genatlas,
shRNA from OriGene, Sigma-Aldrich, RNAi from Sigma-Aldrich,
RNAi Products, Clones, and Q-PCR Products from Invitrogen, Millipore, OriGene, and/or Abnova, siRNAs from Applied Biosystems, SYBR primers from OriGene, Cell-based Assays from Millipore, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
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Inhib. RNA:		Invitrogen RNAi Products for gene knock-down (YPEL1)
		Browse for Gene Knock-down Tools from Millipore
		Browse Abnova for Chimera RNAi Products

OriGene 29mer shRNA kit in GFP-retroviral vector: NM_013313

Applied Biosystems Silencer® siRNAs for YPEL1

Sigma-Aldrich siRNA for YPEL1

Sigma-Aldrich shRNA for YPEL1

Explore Sigma-Aldrich super-pooled esiRNAs

Clones:		Invitrogen Clones for YPEL1
		Browse Clones for the Expression of Recombinant Proteins Available from Millipore

OriGene GFP tagged cDNA clone in CMV expression vector: NM_013313
Myc/DDK tagged cDNA clone in CMV expression vector: NM_013313
untagged cDNA clones in CMV expression vector (see all 2): AF305069

Primers:

Browse Quantitative PCR Central at Invitrogen for Q-PCR LUX™ Primers

OriGene genome-wide validated SYBR primer pairs: NM_013313

UniProtKB/Swiss-Prot: YPEL1_HUMAN, O60688

Function: May play a role in epithelioid conversion of fibroblasts

(Pathways according to Invitrogen (maps by GeneGo), Millipore, Cell Signaling Technology, Sigma-Aldrich, KEGG and/or UniProtKB,
Sets of similar genes according to GeneDecks, Proteins Network according to SABiosciences, Interactions according to ¹UniProtKB, ²MINT, and/or ³STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
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(Chemical Compounds according to UniProtKB, Enzo Life Sciences, Sigma-Aldrich, Tocris Bioscience, and/or Novoseek and Drugs according to Enzo Life Sciences and/or PharmGKB)
About This Section

Browse drugs & compounds from Enzo Life Sciences

Browse Small Molecules at Sigma-Aldrich

Browse Tocris compounds for YPEL1

(GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 219 Homo sapiens; Jun 2 2009) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView,
non coding RNAs according to RNAdb,
ESTs according to GeneTide,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from Invitrogen, Millipore, and/or Abnova,
siRNAs from Applied Biosystems, Sigma-Aldrich,
shRNA from Sigma-Aldrich, OriGene,
Tagged/untagged cDNA clones from OriGene,
Expression Assays from Applied Biosystems)
About This Section

Inhib. RNA:		Invitrogen RNAi Products for gene knock-down (YPEL1)
		Browse for Gene Knock-down Tools from Millipore
		Browse Abnova for Chimera RNAi Products

OriGene 29mer shRNA kit in GFP-retroviral vector: NM_013313

Sigma-Aldrich siRNA for YPEL1

Sigma-Aldrich shRNA for YPEL1

Explore Sigma-Aldrich super-pooled esiRNAs

Applied Biosystems Silencer® siRNAs:

NM_013313

REFSEQ mRNAs for YPEL1 gene:

NM_013313.3

Applied Biosystems TaqMan ® Gene Expression Assays:

NM_013313

              OriGene GFP tagged cDNA clone in CMV expression vector: NM_013313
                                 Myc/DDK tagged cDNA clone in CMV expression vector: NM_013313
                                 untagged cDNA clones in CMV expression vector (see all 2): AF305069

Additional cDNA sequence:

AB098734.1 AB098735.1 AF060862.1 AF305069.1 AK096530.1 BC015229.1 BC034486.1 BC048303.1

BC074501.1 CR456376.2 CR600614.1 CR616192.1 CR933630.1

10 DOTS entries:

DT.100660517 DT.100724398 DT.452431 DT.417942 DT.100660518 DT.97833577 DT.100660513 DT.100673240

DT.100680484 DT.120645770

24/156 AceView cDNA sequences (see all 156 ):

AW160431 AW207054 BE672864 H14672 Z41424 CR456376 BE677438 AI954202

CK822369 Z45781 CK822368 F09469 NM_013313 T33657 BC048303 AI436662

AI440053 AA954374 Z43497 AA443152 CR616192 CA391726 AW162047 AA834555

highest scoring ESTs for YPEL1:

AA007655 AA425563 AF060862 AW160339 AW160431 AW161250 BC048303 BG721344 BI459859 BI461654

Unigene Cluster for YPEL1:

Yippee-like 1 (Drosophila)

Hs.517436 [show with all ESTs]

Unigene Representative Sequence: CR933630

GeneLoc Exon Structure

4 Alternative Splicing Database (ASD) splice patterns (SP) for YPEL1

ExUns:	1a	·	1b	·	1c	^	2a	·	2b	^	3	^	4	^	5a	·	5b	^	6
SP1:									-		-
SP2:											-
SP3:
SP4:									-

About this scheme

ECgene alternative splicing isoforms for YPEL1

2 Ensembl transcripts including schematic representations:

ENST00000339468 ENST00000403503

(Experimental results according to ¹GeneNote and GNF BioGPS,
probe sets-to-genes annotations according to ²GeneAnnot , ³GeneTide , Sets of similar genes according to GeneDecks, Electronic Northern calculations according to data from UniGene (Build 219 Homo sapiens), SAGE tags according to CGAP, plus additional links to SOURCE, and/or GNF BioGPS, and/or EXPOLDB, and/or UniProtKB,
Expression Assays from Applied Biosystems )
About This Section

YPEL1 expression in normal and diseased human tissues

Applied Biosystems TaqMan ® Gene Expression Assays for YPEL1

¹ / ² / ³

9 probe-sets matching YPEL1 gene

Affymetrix probe-set	Array	# genes	Sensitivity	Specificity	Correlation	Length	Gb_Accession	Consensus	Uniqueness	Score	Rank
Affymetrix probe-set	Array	GeneAnnot data			GeneNote data		GeneTide data
60790_at²^{, 3}	U95-C	1	1.00	1.00	0.13	1.29	AA425563	0.80	1.00	0.91	1
40352_at²^{, 3}	U95-A	1	1.00	1.00	0.87	0.67	AF060862	0.80	1.00	0.91	1
52798_at²^{, 3}	U95-B	1	1.00	1.00	0.88	1.05	AA007655	0.80	1.00	0.91	1
213996_at²^{, 3}	U133-A	1	1.00	1.00	--	--	NM_013313	0.60	1.00	0.82	1
228788_at²^{, 3}	U133-B	1	1.00	1.00	--	--	AA425358	0.60	0.75	0.68	1
228296_at²^{, 3}	U133-B	1	1.00	1.00	--	--	AW450686	0.60	1.00	0.82	1
213996_at²	U133Plus2	1	1.00	1.00	--	--	--	--	--	--	--
228788_at²	U133Plus2	1	1.00	1.00	--	--	--	--	--	--	--
228296_at²	U133Plus2	1	1.00	1.00	--	--	--	--	--	--	--

GeneDecks YPEL1 for binary patterns associated with the probe-sets selected above

About GeneDecksing

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Data from

(Publications) and GNF BioGPS
About these images
About these images

CGAP SAGE TAG: --

SOURCE GeneReport for Unigene cluster: Hs.517436
Expression variation in blood from EXPOLDB for YPEL1

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD and/or ⁵MGI Jun 06 2009, with possible further links to Flybase and/or WormBase, Gene Trees according to Ensembl)
About This Section

Orthologs for YPEL1 gene from 5/11 species (see all 11 )

Organism	Gene	Locus	Description	Human Similarity	NCBI accessions
dog (Canis familiaris)	YPEL1¹	--	yippee-like 1 (Drosophila)	91.6(n) 99.16(a)	608652 XM_845743.1 XP_850836.1
chimpanzee (Pan troglodytes)	YPEL1¹	--	yippee-like 1 (Drosophila)	99.44(n) 100(a)	748107 XM_001159736.1 XP_001159736.1
cow (Bos taurus)	YPEL1¹	--	yippee-like 1 (Drosophila)	89.92(n) 99.16(a)	521410 XM_599673.3 XP_599673.2
mouse (Mus musculus)	Ypel1^{1, 5}	16⁵	yippee-like 1 (Drosophila)^{1, 5}	90.4(n)¹ 99.15(a)¹	106369¹ NM_023249.3¹ NP_075738.1¹ AA212096⁵ AB098740⁵ (see all 22)
chicken (Gallus gallus)	YPEL1¹	--	yippee-like 1 (Drosophila)	84.59(n) 100(a)	416774 XM_415068.2 XP_415068.1

About this table Species with no ortholog for YPEL1

ENSEMBL Gene Tree for YPEL1

(Paralogs according to ¹HomoloGene
and ²Ensembl, Pseudogenes according to ³Pseudogene.org)
About This Section

Paralogs for YPEL1 gene

YPEL3² YPEL2² YPEL4² YPEL5²

Pseudogenes

1 related pseudogene

(According to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, and UniProtKB, Linkage Disequilibrium by HapMap, Genotyping Reagents from Applied Biosystems)
About This Section

10/297 NCBI SNPs in YPEL1 are shown (see all 297 )
(Click for Applied Biosystems TaqMan ® Genotyping Assay) (see all 95)

AB	SNP ID	Valid	Chr 22 pos	Sequence	Recs	AA Chg	Type	More	Recs	Allele freq	Pop	Total sample	More
AB	Genomic Data				Transcription Data				Allele Frequencies
				--	--	--		--	--				--
	rs3747094^1,2	A,C,F,H	20383880(+)	`CGGGCA/GACGCG`	1	--	ut3¹ ese³		4		EU EA WA	412
	rs710172^1,2	A,C,F,H	20385280(-)	`CACTCC/TCGGCC`	1	--	ut3¹ ese³		6		MN EU EA WA	776
	rs1045681^1,2	A,C,F,H	20382814(-)	`GAGGTT/CCGTGC`	1	--	ut3¹ ese³		9		MN EU EA WA NA	906
	rs1860^1,2	A,C,F,H	20385394(-)	`TCCTTC/TGAATG`	1	--	ut3¹ ese³ trp³		15		MN EU EA WA NA	1348
	rs861817^1,2	C,F,H	20384607(-)	`aacaaA/Gagaga`	1	--	ut3¹		8		EU EA WA	836
--	rs5994871^1,2	A,C	20421244(+)	`atgatC/Tgcgct`	1	--	ng3¹		0	--	--	--	--
	rs7285388^1,2	A,C	20383776(+)	`TGGATC/TGTAAT`	1	--	ut3¹ ese³		0	--	--	--	--
--	rs9610199^1,2	A,C	20421957(+)	`tgcccC/Tgcacc`	1	--	ng3¹		0	--	--	--	--
	rs2329826^1,2	A	20383107(+)	`CTGCAC/TGCGAG`	1	--	ut3¹ ese³		0	--	--	--	--
	rs3747095^1,2	C	20383885(+)	`AACGCG/TTCTAG`	1	--	ut3¹ ese³		0	--	--	--	--

About this table

HapMap Linkage Disequilibrium images for YPEL1 (up to first 250kb)

(in which this Gene is Involved, According to OMIM, UniProtKB, PharmGKB, Genatlas, GeneTests, Blood group antigen gene mutations by BGMUT, HGMD, GAD, HuGE Navigator, BCGD, and/or TGDB.)
About This Section

OMIM: 608082

(Possibly Related Articles in Doctor's Guide)
About This Section

(in PubMed. Associations of this gene to articles via ¹Novoseek, ²HGNC, ³Entrez Gene, ⁴UniProtKB/Swiss-Prot, ⁵UniProtKB/TrEMBL, ⁶GAD, and/or ⁷PharmGKB)
About This Section

9 PubMed articles for YPEL1 gene:

Identification and characterization of a novel gene family YPEL in a wide spectrum of eukaryotic species. (PubMed id 15556292)^{3, 4} Hosono K.... Shimizu N. (2004)
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)^{3, 4} Gerhard D.S....Malek J. (2004)
A genome annotation-driven approach to cloning the human ORFeome. (PubMed id 15461802)^{3, 4} Collins J.E.... Dunham I. (2004)
Ypel1: a novel nuclear protein that induces an epithelial-like morphology in fibroblasts. (PubMed id 11473580)^{2, 3} Farlie P....Newgreen D. (2001)
The full-ORF clone resource of the German cDNA Consortium. (PubMed id 17974005)⁴ Bechtel S....Schupp I. (2007)
Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)³ Ota T....Sugano S. (2004)
Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)³ Strausberg R.L....Marra M.A. (2002)
[IMAGE: molecular integration of the analysis of the human genome and its expression] (PubMed id 7757816)³ Auffray C....Lamy B. (1995)
Canine Imerslund-Grasbeck syndrome maps to a region orthologous to HSA14q. (PubMed id 14722725)¹ He Q....Henthorn P.S. (2003)

(in PubMed, OMIM, and NCBI Bookshelf)
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		AND	OR
Aliases
Free Text

Query String		PubMed OMIM NCBI Bookshelf
	(Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, and/or H-InvDB)
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Entrez Gene: 29799	HGNC: 12845	AceView: YPEL1	Ensembl:ENSG00000100027	euGenes: HUgn29799
ECgene: YPEL1	H-InvDB: YPEL1

(According to HUGE)
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(According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
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Name	Description
ATLAS Chromosomes in Cancer entry for YPEL1	Genetics and Cytogenetics in Oncology and Haematology

Licensable Technologies for YPEL1
(Available from WIS Yeda, Salk, Tufts)

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(Reagents available from Applied Biosystems, Antibodies and assays by Cell Signaling Technology, Abcam, Novus Biologicals,
Sigma-Aldrich, R&D Systems, Millipore, Abnova, and/or Invitrogen, Clones available from OriGene,and/or Invitrogen, Drugs and/or compounds by Sigma-Aldrich,
Enzo Life Sciences, and/or Tocris Bioscience)
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Products for YPEL1:

TaqMan ® Gene Expression Assays

TaqMan ® Genotyping Assays

Free SNP selection tool

Invitrogen iPath Pathways	Invitrogen BLOCK-iT™ RNAi
Invitrogen Antibodies	Invitrogen Assays
Invitrogen Clones	Invitrogen Q-PCR Products
Invitrogen Human Recombinant Kinases	Invitrogen Custom Antibody and Peptide Service
Invitrogen Proteins / Assays / Screening Services	Search Invitrogen catalog for YPEL1-related products

	Millipore Custom Antibody & Bulk Services
	Millipore Preclinical / Clinical Development Services
	Millipore Immunoassay Services
	Millipore Target Screening & Profiling Services

	Predesigned and custom siRNAs for YPEL1		Browse antibodies at Sigma-Aldrich
	Explore super-pooled esiRNAs		Browse proteins at Sigma-Aldrich
	Lentivirus-delivered shRNAs for YPEL1		Browse small molecules at Sigma-Aldrich
	"Your Favorite Gene" Pathways		feedback

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	Purified proteins from HEK293T cells
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	shRNA in GFP-retroviral vector

Search Tocris compounds for YPEL1

Search www.enzolifesicences.com for proteins, assays, substrates, inhibitors & antibodies

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YPEL1 Gene

protein-coding GIFtS: 50

Aliases &
Descriptions
for YPEL1

Summaries
for YPEL1

Genomic Location
for YPEL1

Proteins
for YPEL1

Protein Domains/
Families
for YPEL1

Gene Function
for YPEL1

Pathways & Interactions
for YPEL1

Drugs & Compounds
for YPEL1

Transcripts
for YPEL1

Expression
for YPEL1

Orthologs
for YPEL1

Paralogs
for YPEL1

SNPs/Variants
for YPEL1

Disorders & Mutations
for YPEL1

Medical News
for YPEL1

Publications
for YPEL1

Search for YPEL1

Genome Databases showing YPEL1

Other Databases showing YPEL1

Specialized Databases showing YPEL1

Licensable Technologies
for YPEL1

Services
for YPEL1

Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

YPEL1 Gene

protein-coding GIFtS: 50

Aliases & Descriptionsfor YPEL1

Summariesfor YPEL1

Genomic Locationfor YPEL1

Proteinsfor YPEL1

Protein Domains/Familiesfor YPEL1

Gene Functionfor YPEL1

Pathways & Interactionsfor YPEL1

Drugs & Compoundsfor YPEL1

Transcriptsfor YPEL1

Expression for YPEL1

Orthologsfor YPEL1

Paralogsfor YPEL1

SNPs/Variantsfor YPEL1

Disorders & Mutationsfor YPEL1

Medical Newsfor YPEL1

Publicationsfor YPEL1

Search for YPEL1

Genome Databases showing YPEL1

Other Databases showing YPEL1

Specialized Databases showing YPEL1

Licensable Technologiesfor YPEL1

Servicesfor YPEL1

Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

Aliases &
Descriptions
for YPEL1

Summaries
for YPEL1

Genomic Location
for YPEL1

Proteins
for YPEL1

Protein Domains/
Families
for YPEL1

Gene Function
for YPEL1

Pathways & Interactions
for YPEL1

Drugs & Compounds
for YPEL1

Transcripts
for YPEL1

Expression
for YPEL1

Orthologs
for YPEL1

Paralogs
for YPEL1

SNPs/Variants
for YPEL1

Disorders & Mutations
for YPEL1

Medical News
for YPEL1

Publications
for YPEL1

Licensable Technologies
for YPEL1

Services
for YPEL1