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Aliases for YPEL1 Gene

Aliases for YPEL1 Gene

  • Yippee Like 1 2 3 5
  • Yippee (Drosophila) Homolog-Like 1 2
  • DiGeorge Syndrome-Related Protein 3
  • Yippee-Like 1 (Drosophila) 2
  • Protein Yippee-Like 1 3
  • FKSG3 3

External Ids for YPEL1 Gene

Previous GeneCards Identifiers for YPEL1 Gene

  • GC22M018753
  • GC22M020379
  • GC22M020377
  • GC22M020381
  • GC22M022051
  • GC22M005009

Summaries for YPEL1 Gene

Entrez Gene Summary for YPEL1 Gene

  • This gene is located in the region associated with DiGeorge syndrome on chromosome 22. The encoded protein localizes to the centrosome and nucleolus and may play a role in the regulation of cell division. [provided by RefSeq, Feb 2015]

GeneCards Summary for YPEL1 Gene

YPEL1 (Yippee Like 1) is a Protein Coding gene. An important paralog of this gene is YPEL2.

UniProtKB/Swiss-Prot for YPEL1 Gene

  • May play a role in epithelioid conversion of fibroblasts.

Additional gene information for YPEL1 Gene

No data available for CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for YPEL1 Gene

Genomics for YPEL1 Gene

Regulatory Elements for YPEL1 Gene

Enhancers for YPEL1 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH22H021712 1.5 FANTOM5 Ensembl ENCODE 16.9 +22.4 22404 1.3 RB1 TBL1XR1 ZSCAN4 INSM2 KLF17 RAD21 GATA2 SCRT2 ZNF143 SMARCA5 PPIL2 IGLV5-52 YPEL1 TOP3B LZTR1 ENSG00000224086 PPM1F ENSG00000234630 RN7SL280P GC22M021698
GH22H021814 1.8 FANTOM5 Ensembl ENCODE dbSUPER 11.4 -81.5 -81483 6.2 PKNOX1 PTBP1 BMI1 BATF SCRT2 FOS ATF7 ETV6 RUNX3 IKZF2 ENSG00000224086 LZTR1 PPM1F ENSG00000272779 IGLV5-52 ENSG00000234630 PPIL2 YPEL1 TOP3B THAP7
GH22H021772 1.3 Ensembl ENCODE dbSUPER 12.7 -38.2 -38213 3.6 HNRNPUL1 HDGF CTCF KLF1 TBL1XR1 TSC22D4 PYGO2 RAD21 RELA IRF9 ENSG00000224086 TOP3B IGLV5-52 LZTR1 YPEL1 TOP3BP1 PPM1F ENSG00000234630 PPIL2 YDJC
GH22H021823 1.1 Ensembl ENCODE dbSUPER 11.7 -88.7 -88667 1.4 HLF JUNB BRF2 FOSL1 JUND FOXJ2 ZNF600 FOS PRDM1 PRDM4 YPEL1 TOP3B ENSG00000224086 RNA5SP493 MAPK1
GH22H021857 1.1 ENCODE dbSUPER 11.7 -122.1 -122050 1.5 ELF3 FOXA2 MLX ARID4B ZSCAN9 RFX5 ETV6 RUNX3 MIXL1 THAP11 ENSG00000224086 YPEL1 MAPK1 RNA5SP493
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around YPEL1 on UCSC Golden Path with GeneCards custom track

Promoters for YPEL1 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000144049 34 1601 HDGF PKNOX1 ATF1 ARNT SIN3A YY1 GATA2 ATF7 RUNX3 CAVIN1

Genomic Locations for YPEL1 Gene

Genomic Locations for YPEL1 Gene
chr22:21,697,536-21,735,834
(GRCh38/hg38)
Size:
38,299 bases
Orientation:
Minus strand
chr22:22,051,825-22,090,123
(GRCh37/hg19)

Genomic View for YPEL1 Gene

Genes around YPEL1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
YPEL1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for YPEL1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for YPEL1 Gene

Proteins for YPEL1 Gene

  • Protein details for YPEL1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    O60688-YPEL1_HUMAN
    Recommended name:
    Protein yippee-like 1
    Protein Accession:
    O60688
    Secondary Accessions:
    • Q65ZA1
    • Q6GLI6

    Protein attributes for YPEL1 Gene

    Size:
    119 amino acids
    Molecular mass:
    13575 Da
    Quaternary structure:
    No Data Available

neXtProt entry for YPEL1 Gene

Post-translational modifications for YPEL1 Gene

No Post-translational modifications

Other Protein References for YPEL1 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for YPEL1 Gene

Domains & Families for YPEL1 Gene

Gene Families for YPEL1 Gene

HGNC:
Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Protein Domains for YPEL1 Gene

Suggested Antigen Peptide Sequences for YPEL1 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

O60688

UniProtKB/Swiss-Prot:

YPEL1_HUMAN :
  • Belongs to the yippee family.
Family:
  • Belongs to the yippee family.
genes like me logo Genes that share domains with YPEL1: view

Function for YPEL1 Gene

Molecular function for YPEL1 Gene

UniProtKB/Swiss-Prot Function:
May play a role in epithelioid conversion of fibroblasts.

Phenotypes From GWAS Catalog for YPEL1 Gene

Gene Ontology (GO) - Molecular Function for YPEL1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0046872 metal ion binding IEA --
genes like me logo Genes that share ontologies with YPEL1: view
genes like me logo Genes that share phenotypes with YPEL1: view

Clone Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for YPEL1 Gene

Localization for YPEL1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for YPEL1 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for YPEL1 gene
Compartment Confidence
nucleus 4
extracellular 3
mitochondrion 2
cytosol 1

Gene Ontology (GO) - Cellular Components for YPEL1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IEA --
genes like me logo Genes that share ontologies with YPEL1: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for YPEL1 Gene

Pathways & Interactions for YPEL1 Gene

SuperPathways for YPEL1 Gene

No Data Available

Interacting Proteins for YPEL1 Gene

Gene Ontology (GO) - Biological Process for YPEL1 Gene

None

No data available for Pathways by source and SIGNOR curated interactions for YPEL1 Gene

Drugs & Compounds for YPEL1 Gene

No Compound Related Data Available

Transcripts for YPEL1 Gene

mRNA/cDNA for YPEL1 Gene

Unigene Clusters for YPEL1 Gene

Yippee-like 1 (Drosophila):
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for YPEL1 Gene

ExUns: 1a · 1b · 1c ^ 2a · 2b ^ 3 ^ 4 ^ 5a · 5b ^ 6
SP1: - -
SP2: -
SP3:
SP4: -

Relevant External Links for YPEL1 Gene

GeneLoc Exon Structure for
YPEL1
ECgene alternative splicing isoforms for
YPEL1

Expression for YPEL1 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for YPEL1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for YPEL1 Gene

This gene is overexpressed in Testis (x17.3).

NURSA nuclear receptor signaling pathways regulating expression of YPEL1 Gene:

YPEL1

SOURCE GeneReport for Unigene cluster for YPEL1 Gene:

Hs.517436

Evidence on tissue expression from TISSUES for YPEL1 Gene

  • Nervous system(4.7)
genes like me logo Genes that share expression patterns with YPEL1: view

No data available for Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for YPEL1 Gene

Orthologs for YPEL1 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for YPEL1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia YPEL1 33 34
  • 99.44 (n)
oppossum
(Monodelphis domestica)
Mammalia YPEL1 34
  • 99 (a)
OneToOne
dog
(Canis familiaris)
Mammalia YPEL1 33 34
  • 91.6 (n)
mouse
(Mus musculus)
Mammalia Ypel1 33 16 34
  • 90.4 (n)
cow
(Bos Taurus)
Mammalia YPEL1 33 34
  • 89.92 (n)
rat
(Rattus norvegicus)
Mammalia Ypel1 33
  • 89.55 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia YPEL1 34
  • 77 (a)
OneToOne
chicken
(Gallus gallus)
Aves YPEL1 33
  • 84.59 (n)
lizard
(Anolis carolinensis)
Reptilia YPEL1 34
  • 100 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia ypel1 33
  • 82.63 (n)
Str.9858 33
African clawed frog
(Xenopus laevis)
Amphibia Xl.23559 33
zebrafish
(Danio rerio)
Actinopterygii ypel1 33 34
  • 84.03 (n)
ypel3 33
fruit fly
(Drosophila melanogaster)
Insecta CG15309 34 35
  • 88 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea F37A8.5 35 34
  • 87 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes MOH1 34
  • 36 (a)
OneToMany
thale cress
(Arabidopsis thaliana)
eudicotyledons AT4G27745 33
  • 61.56 (n)
rice
(Oryza sativa)
Liliopsida Os11g0551800 33
  • 62.24 (n)
sea squirt
(Ciona savignyi)
Ascidiacea -- 34
  • 79 (a)
OneToMany
Species where no ortholog for YPEL1 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for YPEL1 Gene

ENSEMBL:
Gene Tree for YPEL1 (if available)
TreeFam:
Gene Tree for YPEL1 (if available)

Paralogs for YPEL1 Gene

Paralogs for YPEL1 Gene

(4) SIMAP similar genes for YPEL1 Gene using alignment to 2 proteins:

Pseudogenes.org Pseudogenes for YPEL1 Gene

genes like me logo Genes that share paralogs with YPEL1: view

Variants for YPEL1 Gene

Sequence variations from dbSNP and Humsavar for YPEL1 Gene

SNP ID Clin Chr 22 pos Sequence Context AA Info Type
rs1000044355 -- 21,737,634(+) CAAGA(A/C)ACAAT upstream-variant-2KB
rs1000133861 -- 21,715,658(+) CTCAC(C/T)GCAAC intron-variant
rs1000274827 -- 21,719,222(+) CCACA(C/T)GGTGC intron-variant
rs1000276816 -- 21,701,871(+) CCTAC(A/G)CAACA intron-variant
rs1000424062 -- 21,732,478(+) AGACA(A/T)ATATG intron-variant

Structural Variations from Database of Genomic Variants (DGV) for YPEL1 Gene

Variant ID Type Subtype PubMed ID
nsv955499 CNV deletion 24416366
nsv7350 OTHER inversion 18451855
nsv588322 CNV loss 21841781
nsv510804 CNV deletion 20534489
nsv191511 CNV deletion 16902084
nsv1060548 CNV gain 25217958
esv3557950 CNV deletion 23714750
esv2678585 CNV deletion 23128226
dgv1293e212 CNV loss 25503493

Variation tolerance for YPEL1 Gene

Residual Variation Intolerance Score: 45% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for YPEL1 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
YPEL1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for YPEL1 Gene

Disorders for YPEL1 Gene

Relevant External Links for YPEL1

Genetic Association Database (GAD)
YPEL1
Human Genome Epidemiology (HuGE) Navigator
YPEL1
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
YPEL1

No disorders were found for YPEL1 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for YPEL1 Gene

Publications for YPEL1 Gene

  1. Identification and characterization of a novel gene family YPEL in a wide spectrum of eukaryotic species. (PMID: 15556292) Hosono K … Shimizu N (Gene 2004) 2 3 4 60
  2. Centrosome-related genes, genetic variation, and risk of breast cancer. (PMID: 20508983) Olson JE … Couch FJ (Breast cancer research and treatment 2011) 3 45 60
  3. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose JE … Uhl GR (Molecular medicine (Cambridge, Mass.) 2010) 3 45 60
  4. A genome annotation-driven approach to cloning the human ORFeome. (PMID: 15461802) Collins JE … Dunham I (Genome biology 2004) 3 4 60
  5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 60

Products for YPEL1 Gene

Sources for YPEL1 Gene

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