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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

YOD1 Gene

protein-coding   GIFtS: 48
GCID: GC01M207217

YOD1 Deubiquitinase

(Previous names: YOD1 OTU deubiquinating enzyme 1 homolog ( yeast), YOD1...)
  Search for YOD1
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
YOD1 Deubiquitinase1 2     PRO09072
DUBA82 3 5     hsHIN72
OTUD22 3 5     OTU Domain Containing 22
YOD1 OTU Deubiquinating Enzyme 1 Homolog ( Yeast)1 2     Ubiquitin Thioesterase OTU12
DUBA-82 3     EC 3.4.19.123
HIN-72 3     HIN73
HIV-1-Induced Protease 72 3     HsHIN73
OTU Domain-Containing Protein 22 3     EC 3.1.28
YOD1 OTU Deubiquinating Enzyme 1 Homolog (S. Cerevisiae)1     

External Ids:    HGNC: 250351   Entrez Gene: 554322   Ensembl: ENSG000001806677   OMIM: 6120235   UniProtKB: Q5VVQ63   

Export aliases for YOD1 gene to outside databases

Previous GC identifers: GC01M203608 GC01M205284 GC01M177914


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for YOD1 Gene:
Protein ubiquitination controls many intracellular processes, including cell cycle progression, transcriptional
activation, and signal transduction. This dynamic process, involving ubiquitin conjugating enzymes and
deubiquitinating enzymes, adds and removes ubiquitin. Deubiquitinating enzymes are cysteine proteases that
specifically cleave ubiquitin from ubiquitin-conjugated protein substrates. The protein encoded by this gene
belongs to a DUB subfamily characterized by an ovarian tumor (OTU) domain. Alternative splicing results in
multiple transcript variants. (provided by RefSeq, Jan 2013)

GeneCards Summary for YOD1 Gene: 
YOD1 (YOD1 deubiquitinase) is a protein-coding gene. GO annotations related to this gene include ubiquitin-specific protease activity and zinc ion binding.

UniProtKB/Swiss-Prot: OTU1_HUMAN, Q5VVQ6
Function: Hydrolase that can remove conjugated ubiquitin from proteins and participates in endoplasmic
reticulum-associated degradation (ERAD) for misfolded lumenal proteins. May act by triming the ubiquitin chain on
the associated substrate to facilitate their threading through the VCP/p97 pore. Ubiquitin moieties on substrates
may present a steric impediment to the threading process when the substrate is transferred to the VCP pore and
threaded through VCP's axial channel. Mediates deubiquitination of both 'Lys-48'- and 'Lys-63'-linked
polyubiquitin chains. Able to cleave both polyubiquitin and di-ubiquitin




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000001.10  NT_167186.1  NC_018912.2  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the YOD1 gene promoter:
         E2F-4   E2F-3a   E2F-5   HTF   E2F-2   GATA-2   GATA-1   E2F-1   E2F   HSF2   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidYOD1 promoter sequence
   Search SABiosciences Chromatin IP Primers for YOD1

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat YOD1


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 1q32.2   Ensembl cytogenetic band:  1q32.2   HGNC cytogenetic band: 1q32.2

YOD1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
YOD1 gene location

GeneLoc information about chromosome 1         GeneLoc Exon Structure

GeneLoc location for GC01M207217:  view genomic region     (about GC identifiers)

Start:
207,217,194 bp from pter      End:
207,226,325 bp from pter
Size:
9,132 bases      Orientation:
minus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: OTU1_HUMAN, Q5VVQ6 (See protein sequence)
Recommended Name: Ubiquitin thioesterase OTU1  
Size: 348 amino acids; 38322 Da
Subunit: Interacts with VCP; the interaction is direct. Interacts with FAF2/UBXD8. Interacts with DERL1; however
interaction is dependent on the UBAX-like region, suggesting that it may be indirect
Sequence caution: Sequence=AAF71033.1; Type=Erroneous translation; Note=Wrong choice of frame;
Sequence=EAW93510.1; Type=Erroneous gene model prediction;
Secondary accessions: B2RNX3 Q5VVQ5 Q6ZRS6 Q86T63 Q9P1L8
Alternative splicing: 2 isoforms:  Q5VVQ6-1   Q5VVQ6-2   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for YOD1: NX_Q5VVQ6

Explore proteomics data for YOD1 at MOPED 

Post-translational modifications:

  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_Q5VVQ6

  • 4/7 DME Specific Peptides for YOD1 (Q5VVQ6) (see all 7)
     LRCMVCQ  CQKGLTGQ  DGIHYDPL  YYVVEGGV 

    YOD1 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    YOD1 Protein Expression
    REFSEQ proteins (2 alternative transcripts): 
    NP_001263249.1  NP_061036.3  

    ENSEMBL proteins: 
     ENSP00000326813   ENSP00000356051   ENSP00000375793  

    Human Recombinant Protein Products for YOD1: 
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    Novus Biologicals YOD1 Protein
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    Cloud-Clone Corp. Proteins for YOD1 


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    LSBio Antibodies in human, mouse, rat for YOD1 

    Assay Products for YOD1: 
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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    HGNC Gene Families: 
    OTUD: OTU domain containing

    3 InterPro protein domains:
     IPR015880 Znf_C2H2-like
     IPR003323 OTU
     IPR007087 Znf_C2H2

    Graphical View of Domain Structure for InterPro Entry Q5VVQ6

    ProtoNet protein and cluster: Q5VVQ6

    UniProtKB/Swiss-Prot: OTU1_HUMAN, Q5VVQ6
    Domain: The UBAX-like region mediates the interaction with VCP. According to PubMed:19818707, it corresponds to a
    UBX domain, which is a hallmark for VCP-associated proteins. However, no canonical UBX is detected by prediction
    tools such as Pfam or PROSITE
    Similarity: Contains 1 C2H2-type zinc finger
    Similarity: Contains 1 OTU domain


    YOD1 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: OTU1_HUMAN, Q5VVQ6
    Function: Hydrolase that can remove conjugated ubiquitin from proteins and participates in endoplasmic
    reticulum-associated degradation (ERAD) for misfolded lumenal proteins. May act by triming the ubiquitin chain on
    the associated substrate to facilitate their threading through the VCP/p97 pore. Ubiquitin moieties on substrates
    may present a steric impediment to the threading process when the substrate is transferred to the VCP pore and
    threaded through VCP's axial channel. Mediates deubiquitination of both 'Lys-48'- and 'Lys-63'-linked
    polyubiquitin chains. Able to cleave both polyubiquitin and di-ubiquitin
    Catalytic activity: Thiol-dependent hydrolysis of ester, thioester, amide, peptide and isopeptide bonds formed by
    the C-terminal Gly of ubiquitin (a 76-residue protein attached to proteins as an intracellular targeting signal)

         Enzyme Numbers (IUBMB): EC 3.1.22 EC 3.4.19.121

         Gene Ontology (GO): 4 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004843ubiquitin-specific protease activity IDA19818707
    GO:0005515protein binding IPI19818707
    GO:0008270zinc ion binding ----
    GO:0046872metal ion binding IEA--
         
    YOD1 for ontologies           About GeneDecksing


    Animal Models:
       inGenious Targeting Laboratory - Custom generated mouse model solutions for YOD1 
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       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for YOD1 
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    hsa-miR-579 hsa-miR-140-5p hsa-miR-100* hsa-miR-607 hsa-miR-520f hsa-miR-520e hsa-miR-3607-3p hsa-miR-3146
    Browse SwitchGear 3'UTR luciferase reporter plasmids
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for YOD1


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section

    SuperPaths for YOD1 About                                                                                                See pathways by source

    SuperPathContained pathways About
    1Protein processing in endoplasmic reticulum
    Protein processing in endoplasmic reticulum

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways



    1         Kegg Pathway  (Kegg details for YOD1):
        Protein processing in endoplasmic reticulum


    YOD1 for pathways           About GeneDecksing

    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for YOD1

    STRING Interaction Network Preview (showing 5 interactants - click image to see 17)

    5/41 Interacting proteins for YOD1 (Q5VVQ63 ENSP000003268134) via UniProtKB, MINT, STRING, and/or I2D (see all 41)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    HIST1H4AP628053I2D: score=1 
    HIST1H4BP628053I2D: score=1 
    HIST1H4CP628053I2D: score=1 
    HIST1H4DP628053I2D: score=1 
    HIST1H4EP628053I2D: score=1 
    About this table

    Gene Ontology (GO): 5/9 biological process terms (GO ID links to tree view) (see all 9):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006520cellular amino acid metabolic process ISS--
    GO:0030433ER-associated protein catabolic process IMP19818707
    GO:0030968endoplasmic reticulum unfolded protein response IMP19818707
    GO:0035523protein K29-linked deubiquitination IDA--
    GO:0035871protein K11-linked deubiquitination IDA--

    YOD1 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for YOD1 (OTU1)

    Search CenterWatch for drugs/clinical trials and news about YOD1 / OTU1

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for YOD1 gene (2 alternative transcripts): 
    NM_001276320.1  NM_018566.3  

    Unigene Clusters for YOD1:

    YOD1 OTU deubiquinating enzyme 1 homolog (S. cerevisiae)
    Hs.567533  [show with all ESTs], Hs.745490  [show with all ESTs]
    Unigene Representative Sequences: NM_001276320, NM_018566
    3 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000315927(uc001hfe.1) ENST00000367084(uc001hff.1) ENST00000391927

    miRNA
    Products:
         
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    8/117 QIAGEN miScript miRNA Assays for microRNAs that regulate YOD1 (see all 117):
    hsa-miR-579 hsa-miR-140-5p hsa-miR-100* hsa-miR-607 hsa-miR-520f hsa-miR-520e hsa-miR-3607-3p hsa-miR-3146
    Browse SwitchGear 3'UTR luciferase reporter plasmids
    Inhib. RNA
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    Browse for Gene Knock-down Tools from EMD Millipore
    OriGene RNAi products in human, mouse, rat for YOD1
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat YOD1
    Clone
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    OriGene clones in human, mouse for YOD1 (see all 7)
    OriGene ORF clones in mouse, rat for YOD1
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: YOD1 (NM_002478)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for YOD1
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat YOD1
    Sirion Biotech Customized lentivirus for stable overexpression of YOD1 
                         Customized lentivirus expression plasmids for stable overexpression of YOD1 
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      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat YOD1
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat YOD1

    Additional mRNA sequence: 

    AL833081.2 BC137166.1 BC137167.1 

    5 DOTS entries:

    DT.95151639  DT.100651383  DT.87017586  DT.410129  DT.91809420 

    24/60 AceView cDNA sequences (see all 60):

    BX281286 BU677062 CR590739 AA830040 CB120592 AF116608 AA338005 CF143691 
    CB136300 BX325304 AL833081 AA279267 AI690940 BU633998 AI065073 BG035362 
    BU608976 BU754342 AA687363 BF436566 CD653082 AA521103 BX324620 AL121343 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    YOD1 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: AGTCTACTTT
    YOD1 Expression
    About this image


    See YOD1 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for YOD1

    SOURCE GeneReport for Unigene clusters: Hs.567533 Hs.745490
        SABiosciences Custom PCR Arrays for YOD1
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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for YOD1

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of eukaryotes.

    Orthologs for YOD1 gene from 8/19 species (see all 19)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Yod11 , 5 YOD1 OTU deubiquitinating enzyme 1 homologue (S. cerevisiae)1, 5 87.76(n)1
    88.63(a)1
      1 (56.89 cM)5
    2264181  NM_178691.41  NP_848806.21 
     1307173275 
    chicken
    (Gallus gallus)
    Aves YOD11 YOD1 OTU deubiquinating enzyme 1 homolog (S. cerevisiae) 69.66(n)
    74.09(a)
      428266  NM_001031499.1  NP_001026670.1 
    lizard
    (Anolis carolinensis)
    Reptilia YOD16
    Uncharacterized protein
    73(a)
    1 ↔ 1
    GL343228.1(2100891-2105951)
    zebrafish
    (Danio rerio)
    Actinopterygii yod11 YOD1 OTU deubiquinating enzyme 1 homolog (S. cerevisiae) 65.89(n)
    71.1(a)
      550411  NM_001017716.1  NP_001017716.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta CG46031 CG4603 50.78(n)
    48.32(a)
      38603  NM_139694.3  NP_647951.2 
    baker's yeast
    (Saccharomyces cerevisiae)
    Saccharomycetes OTU1(YFL044C)4
    OTU11
    Deubiquitylation enzyme that binds to the chaperone-ATPase more4
    Otu1p1
    48.12(n)1
    37.66(a)1
      6(45560-44655)4
    8505001, 4  NP_116610.11, 4 
    thale cress
    (Arabidopsis thaliana)
    eudicotyledons AT1G506701 ubiquitin thioesterase OTU1 53.64(n)
    48.73(a)
      841489  NM_103949.3  NP_175482.1 
    rice
    (Oryza sativa)
    Liliopsida Os02g01648001 hypothetical protein 56.21(n)
    54.9(a)
      4328405  NM_001052527.1  NP_001045992.1 


    ENSEMBL Gene Tree for YOD1 (if available)
    TreeFam Gene Tree for YOD1 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
      --

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/182 SNPs in YOD1 are shown (see all 182)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 1 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs28427411,2
    C,F,O,A,H--207216695(+) CGTCCA/GTAATT 2 -- ds500115Minor allele frequency- G:0.13NA EA NS WA 1594
    rs1501956281,2
    --207216713(+) TTTCAA/GTGAGA 2 -- ds50010--------
    rs1158431661,2
    C,F--207216766(+) TCTGGC/TCAATT 2 -- ds50011Minor allele frequency- T:0.01NA 120
    rs1846109231,2
    --207216770(+) GCCAAG/TTGTAA 2 -- ds50010--------
    rs1891288151,2
    --207216808(+) TTTAAA/GTGTTG 2 -- ds50010--------
    rs788196171,2
    F--207216871(+) CAGATC/TTAAGT 2 -- ds50011Minor allele frequency- T:0.01WA 118
    rs1456922631,2
    --207216892(+) TGCAGC/TCTATT 2 -- ds50010--------
    rs782957301,2
    F--207217029(+) AGAAAT/CACCTT 2 -- ds50012Minor allele frequency- C:0.04CSA WA 120
    rs118020371,2
    C,F,H--207217062(+) GAGTCC/TGCCTA 2 -- ds500110Minor allele frequency- T:0.06NS EA NA WA 1208
    rs1166908671,2
    C,F--207217063(+) AGTCCG/ACCTAA 2 -- ds50011Minor allele frequency- A:0.02WA 118

    HapMap Linkage Disequilibrium report for YOD1 (207217194 - 207226325 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 1 variation for YOD1:    About this table     
    Variant IDTypeSubtypePubMed ID
    nsv832426CNV Gain17160897

    SABiosciences Cancer Mutation PCR Assays
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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section

    YOD1 for disorders           About MalaCards
    OMIM gene information: 612023    OMIM disorders: --


    YOD1 for disorders           About GeneDecksing

    Genetic Association Database (GAD): YOD1

    Export disorders for YOD1 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for YOD1 gene, integrated from 9 sources (see all 18):
    (articles sorted by number of sources associating them with YOD1)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. The otubain YOD1 is a deubiquitinating enzyme that associates with p97 to facilitate protein dislocation from the ER. (PubMed id 19818707)1, 2 Ernst R.... Schlieker C. (2009)
    2. The DNA sequence and biological annotation of human chromosome 1. (PubMed id 16710414)1, 2 Gregory S.G.... Bentley D.R. (2006)
    3. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
    4. Proteome-wide identification of ubiquitylation sites b y conjugation of engineered lysine-less ubiquitin. (PubMed id 22053931)1 Oshikawa K....Nakayama K.I. (2012)
    5. A microarray of ubiquitylated proteins for profiling d eubiquitylase activity reveals the critical roles of both chain and substrate. (PubMed id 22626734)1 Loch C.M. and Strickler J.E. (2012)
    6. Methods for quantification of in vivo changes in prote in ubiquitination following proteasome and deubiquitinase inhibition. (PubMed id 22505724)1 Udeshi N.D....Carr S.A. (2012)
    7. Initial characterization of the human central proteome. (PubMed id 21269460)2 Burkard T.R.... Colinge J. (2011)
    8. Activity-based chemical proteomics accelerates inhibi tor development for deubiquitylating enzymes. (PubMed id 22118674)1 Altun M....Kessler B.M. (2011)
    9. Systematic and quantitative assessment of the ubiquiti n-modified proteome. (PubMed id 21906983)1 Kim W....Gygi S.P. (2011)
    10. Mass spectrometric analysis of lysine ubiquitylation r eveals promiscuity at site level. (PubMed id 21139048)1 Danielsen J.M....Nielsen M.L. (2011)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
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    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 55432 HGNC: 25035 AceView: DKFZp451J1719 Ensembl:ENSG00000180667 euGenes: HUgn55432
    ECgene: YOD1 Kegg: 55432 H-InvDB: YOD1

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for YOD1 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for YOD1 gene:
    Search GeneIP for patents involving YOD1

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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    GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 3 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

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