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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

YME1L1 Gene

protein-coding   GIFtS: 56
GCID: GC10M027439

YME1-like 1 (S. cerevisiae)

(Previous name: YME1 (S.cerevisiae)-like 1 )
 Explore 4 diseases affiliated with
YME1L1 via our new
 Human Malady Compendium 
Biological research products
for YME1L1
    

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, and/or 10fRNAdb)
About This Section

Aliases
YME1-Like 1 (S. Cerevisiae)1 2     ATP-Dependent Metalloprotease YME1L12
PAMP2 3 5     ATP-Dependent Zinc Metalloprotease YME1L12
YME1L2 3 5     Meg-43
Presenilin-Associated Metalloprotease2 3     EC 3.4.24.-3
YME1-Like Protein 12 3     FTSH13
YME1 (S.Cerevisiae)-Like 11     Meg-43
FTSH2     ATP-Dependent Metalloprotease FtsH13
MEG42     EC 3.4.248
ATP-Dependent Metalloprotease FtsH1 Homolog2     

External Ids:    HGNC: 128431   Entrez Gene: 107302   Ensembl: ENSG000001367587   OMIM: 6074725   UniProtKB: Q96TA23   

Export aliases for YME1L1 gene to outside databases

Previous GC identifers: GC10M027134 GC10M027549 GC10M027403 GC10M027068


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for YME1L1:
The protein encoded by this gene is the human ortholog of yeast mitochondrial AAA metalloprotease, Yme1p. It is
localized in the mitochondria and can functionally complement a yme1 disruptant yeast strain. It is proposed that this
gene plays a role in mitochondrial protein metabolism and could be involved in mitochondrial pathologies. Three
transcript variants encoding different isoforms have been found for this gene. (provided by RefSeq, Dec 2011)

UniProtKB/Swiss-Prot: YMEL1_HUMAN, Q96TA2
Function: Putative ATP-dependent protease which plays a role in mitochondrial protein metabolism. Ensures cell
proliferation, maintains normal cristae morphology and complex I respiration activity, promotes antiapoptotic activity
and protects mitochondria from the accumulation of oxidatively damaged membrane proteins. Requires to control the
accumulation of nonassembled respiratory chain subunits (NDUFB6, OX4 and ND1). Seems to act in the processing of OPA1

Gene Wiki entry for YME1L1


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000010.10  NC_018921.1  NT_008705.16  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the YME1L1 gene promoter:
         ATF-2   c-Jun   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidYME1L1 promoter sequence
   Search SABiosciences Chromatin IP Primers for YME1L1

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat YME1L1


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 10p14   Ensembl cytogenetic band:  10p12.1   HGNC cytogenetic band: 10p14

YME1L1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
YME1L1 gene location

GeneLoc information about chromosome 10         GeneLoc Exon Structure

GeneLoc location for GC10M027439:  view genomic region     (about GC identifiers)

Start:
27,399,383 bp from pter      End:
27,444,195 bp from pter
Size:
44,813 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section

UniProtKB/Swiss-Prot: YMEL1_HUMAN, Q96TA2 (See protein sequence)
Recommended Name: ATP-dependent zinc metalloprotease YME1L1  
Size: 773 amino acids; 86455 Da
Cofactor: Binds 1 zinc ion per subunit (Potential)
Subunit: Exists in several complexes of 600-1100 kDa
Subcellular location: Mitochondrion inner membrane
Secondary accessions: B4DNM1 D3DRV8 D3DRV9 Q5T8D9 Q9H1Q0 Q9UMR9
Alternative splicing: 3 isoforms:  Q96TA2-1   Q96TA2-2   Q96TA2-3   (Mutagenesis of Glu-543 to Gln does not complement excessive accumulation of subunits (NDUFB6, COX4,ND1) due to YME1 deletion mutant. Probably has no ATPase activity)

Explore the universe of human proteins at neXtProt for YME1L1: NX_Q96TA2

Post-translational modifications:

  • View modification sites using PhosphoSitePlus2
  • View neXtProt modification sites for NX_Q96TA2

  • 4/8 DME Specific Peptides for YME1L1 (Q96TA2) (see all 8)
     EMFVGVG  AKANAPC  GRTEILK  QTINQLL 

    YME1L1 Protein expression data from MOPED and PaxDb:    About this image 
    Estimated protein expression log10 (pmol).

    REFSEQ proteins (3 alternative transcripts): 
    NP_001240795.1  NP_055078.1  NP_647473.1  

    ENSEMBL proteins: 
     ENSP00000365184   ENSP00000318480   ENSP00000398713   ENSP00000379590   ENSP00000365139  

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    Uscn Proteins for YME1L1

    Gene Ontology (GO): 4 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005739mitochondrion ----
    GO:0005743mitochondrial inner membrane IDA--
    GO:0016020membrane ----
    GO:0016021integral to membrane IEA--


    YME1L1 for ontologies           About GeneDecksing



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    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section

    YME1L1 for domains           About GeneDecksing

    5 InterPro domains/families:
     IPR003959 ATPase_AAA_core
     IPR003960 ATPase_AAA_CS
     IPR000642 Peptidase_M41
     IPR005936 FtsH
     IPR003593 AAA+_ATPase

    Graphical View of Domain Structure for InterPro Entry Q96TA2

    ProtoNet protein and cluster: Q96TA2

    2 Blocks protein families:
    IPB000642 Peptidase M41
    IPB003960 AAA-protein subdomain


    UniProtKB/Swiss-Prot: YMEL1_HUMAN, Q96TA2
    Similarity: In the N-terminal section; belongs to the AAA ATPase family
    Similarity: In the C-terminal section; belongs to the peptidase M41 family


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
    About This Section

    Function Summary:

         UniProtKB/Swiss-Prot: YMEL1_HUMAN, Q96TA2
    Function: Putative ATP-dependent protease which plays a role in mitochondrial protein metabolism. Ensures cell
    proliferation, maintains normal cristae morphology and complex I respiration activity, promotes antiapoptotic activity
    and protects mitochondria from the accumulation of oxidatively damaged membrane proteins. Requires to control the
    accumulation of nonassembled respiratory chain subunits (NDUFB6, OX4 and ND1). Seems to act in the processing of OPA1

    Enzyme Numbers (IUBMB): EC 3.4.24.-1 EC 3.4.242

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    hsa-miR-548j hsa-miR-429 hsa-miR-124 hsa-miR-548a-5p hsa-miR-548d-5p hsa-miR-506 hsa-miR-200b hsa-miR-509-3-5p
    SwitchGear 3'UTR luciferase reporter plasmidYME1L1 3' UTR sequence
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    Gene Ontology (GO): 4 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004222metalloendopeptidase activity IEA--
    GO:0005524ATP binding IEA--
    GO:0017111nucleoside-triphosphatase activity IEA--
    GO:0046872metal ion binding IEA--


    YME1L1 for ontologies           About GeneDecksing


    2 GenomeRNAi human phenotypes for YME1L1:
     Increased cell number in G1, s  Synthetic lethal with Ras 

    Animal Models:
         1 MGI phenotypic allele for Yme1l1 (no phenotypes)

    YME1L1 for phenotypes           About GeneDecksing


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
    About This Section



    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for YME1L1

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    5/398 Interacting proteins for YME1L1 (Q96TA22, 3 ENSP000003184804) via UniProtKB, MINT, STRING, and/or I2D (see all 398)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    AFG3L2Q9Y4W62, 3, ENSP000002691434MINT-8079030 I2D: score=1 STRING: ENSP00000269143
    ATP5BP065762, 3, ENSP000002620304MINT-8079030 I2D: score=1 STRING: ENSP00000262030
    ATP5C1P365422, 3, ENSP000003491424MINT-8079030 I2D: score=1 STRING: ENSP00000349142
    HSPA9P386462, 3MINT-8079030 I2D: score=1 
    SLC25A1P530072, 3MINT-8079030 I2D: score=1 
    About this table

    Gene Ontology (GO): 5/6 biological process terms (GO ID links to tree view) (see all 6):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006508proteolysis ----
    GO:0006515misfolded or incompletely synthesized protein catabolic process IMP--
    GO:0007005mitochondrion organization IMP--
    GO:0008283cell proliferation IMP--
    GO:0030163protein catabolic process ----


    YME1L1 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section

    YME1L1 for compounds           About GeneDecksing

    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for YME1L1
    1 Novoseek chemical compound relationship for YME1L1 gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    atp 10.1 3 15803409 (2), 15047485 (1)

    Search CenterWatch for drugs/clinical trials and news about YME1L1 / YMEL1 

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for YME1L1 gene (4 alternative transcripts): 
    NM_001253866.1  NM_014263.3  NM_139312.2  NM_139313.1  

    Unigene Clusters for YME1L1:

    YME1-like 1 (S. cerevisiae)
    Hs.74647  [show with all ESTs], Hs.499145  [show with all ESTs]
    Unigene Representative Sequences: X73617, BC024215
    9 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000376016(uc001itj.3 uc010qdl.2) ENST00000326799(uc001iti.3)
    ENST00000463270 ENST00000491542 ENST00000493741 ENST00000427324 ENST00000396296
    ENST00000477432(uc001itk.2) ENST00000375972

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    8/35 QIAGEN miScript miRNA Assays for microRNAs that regulate YME1L1 (see all 35):
    hsa-miR-548j hsa-miR-429 hsa-miR-124 hsa-miR-548a-5p hsa-miR-548d-5p hsa-miR-506 hsa-miR-200b hsa-miR-509-3-5p
    SwitchGear 3'UTR luciferase reporter plasmidYME1L1 3' UTR sequence
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    Additional cDNA sequence: 

    AF070656.1 AF151782.1 AJ132637.1 AK001259.1 AK022930.1 AK291292.1 AK297973.1 AK309708.1 
    AK314372.1 AY358484.1 BC007795.2 BC019602.1 BC023507.2 BC024032.2 BC024215.1 

    24/117 DOTS entries (see all 117):

    DT.75111939  DT.100840954  DT.416839  DT.91929548  DT.100645914  DT.95070986  DT.102840523  DT.97845698 
    DT.75187431  DT.96086423  DT.91863912  DT.120744259  DT.102845570  DT.95189905  DT.92338901  DT.95228736 
    DT.91659769  DT.95160576  DT.97847759  DT.75187239  DT.91641502  DT.95292892  DT.95160588  DT.95363549 

    24/530 AceView cDNA sequences (see all 530):

    BM556685 AA285032 BM787580 BX472489 BP872267 CB161024 AI739557 BM768047 
    CA310172 BF796410 AW963623 BM980852 BF793595 CB119538 BU156440 F03137 
    AL701495 BI856907 AA452392 AA926753 BX406565 NM_014263 AW139700 BM793392 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    YME1L1 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS
    CGAP TAG: CTGTTATAGG

    Microarray
    RNAseq (Illumina Body Map)
    (100×FPKM)½
    SAGE (Serial Analysis of Gene Expression)

    About this image
    See YME1L1 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for YME1L1

    SOURCE GeneReport for Unigene clusters: Hs.74647 Hs.499145

    UniProtKB/Swiss-Prot: YMEL1_HUMAN, Q96TA2
    Tissue specificity: High expression in cardiac and skeletal muscle mitochondria

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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for YME1L1

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the last universal common ancestor (LUCA).

    Orthologs for YME1L1 gene from 8/34 species (see all 34)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    chicken
    (Gallus gallus)
    Aves YME1L11 YME1-like 1 (S. cerevisiae) 77.31(n)
    82.21(a)
      428418  NM_001031512.1  NP_001026683.1 
    lizard
    (Anolis carolinensis)
    Reptilia YME1L16
    --
    83(a)
    1 ↔ 1
    6(14472207-14491697)
    zebrafish
    (Danio rerio)
    Actinopterygii BI897858.12   -- 94.37(n)    BI897858.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta CG34991 , 3 ATP-dependent peptidase3
    CG34991
    54(a)3
    56.65(n)1
    55.76(a)1
      59B43
    376361  NM_166568.21  NP_726263.11 
    worm
    (Caenorhabditis elegans)
    Secernentea M03C11.53 ATP-binding protein (AAA protein family
    member)
    55(a)   III(10487806-10493012)   --
    thale cress
    (Arabidopsis thaliana)
    eudicotyledons ftsh46
    FTSH116
    (see all 11)
    cell division protease ftsH-11
    (see all 11)
    37(a)
    34(a)
    (see all 11)
    1 ↔ many
    1 ↔ many
    (see all 11)
    2(11131578-11135345)
    5(21562747-21568012)
    rice
    (Oryza sativa)
    Liliopsida NM_193606.12   -- 72.29(n)    NM_193606.1 
    E. coli
    (Escherichia coli)
    Gamma proteobacteria ftsH6
    protease, ATP-dependent zinc-metallo
    36(a)
    possible ortholog
    Chromosome(3323023-3324957)


    ENSEMBL Gene Tree for YME1L1 (if available)
    TreeFam Gene Tree for YME1L1 (if available) 

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for YME1L1 gene
    6 SIMAP similar genes for YME1L1 using alignment to 5 protein entries:     YMEL1_HUMAN (see all proteins):
    FTSH    AFG3L2    SPG7    PSMC2    PSMC5    PSMC6

    YME1L1 for paralogs           About GeneDecksing


    4 Pseudogenes.org Pseudogenes for YME1L1
    PGOHUM00000248000 PGOHUM00000234779 PGOHUM00000246193 PGOHUM00000240299


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/911 NCBI SNPs in YME1L1 are shown (see all 911    About this table
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 10 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1442130521,2
    C,--27398605(+) TCAAG-/ATCC  
            
    ATCTG
    3 -- ds50010--------
    rs604717611,2
    C--27398608(+) AGATC-/CATC  
            
    TGATA
    3 -- ds50010--------
    rs1405227491,2
    --27398774(+) ATGATC/GTAACT 3 -- ds50010--------
    rs1456153311,2
    --27398883(+) TCCTAC/TATTGC 3 -- ds50010--------
    rs110155361,2
    C,F,--27399003(+) TCTAAT/CTGTGG 3 -- ds50018Minor allele frequency- C:0.29NA WA CSA EA 367
    rs1846547911,2
    --27399024(+) ACACAC/TAACAT 3 -- ds50010--------
    rs1466491151,2
    --27399082(+) CTCAAC/TAAATA 3 -- ut310--------
    rs74778061,2
    C,F,A,H,--27399117(+) GACTTT/CATCAA 3 -- ut3120Minor allele frequency- C:0.35NS EA NA WA 2230
    rs735980201,2
    C,--27399132(+) TTATAC/GGTGTA 3 -- ut314Minor allele frequency- G:0.05WA CSA NA 241
    rs1414186761,2
    --27399165(+) GACAGA/GACAGG 3 -- ut310--------

    HapMap Linkage Disequilibrium report for YME1L1 (27399383 - 27444195 bp)
    Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
    Database of Genomic Variants (DGV): 1 variation for YME1L1
         1 CNV: 5416

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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section

    YME1L1 for disorders           About GeneDecksing

    OMIM gene information: 607472    OMIM disorders: --

    4 diseases for YME1L1:    About MalaCards
    alzheimer's disease    tuberculosis    malaria    mycobacterium tuberculosis

    1 disease from the University of Copenhagen DISEASES database for YME1L1:
    Pulmonary valve insufficiency
    Human Genome Epidemiology (HuGE) Navigator: YME1L1 (2 documents)

    Export disorders for YME1L1 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for YME1L1 gene, integrated from 9 sources (see all 47):
    (articles sorted by number of sources associating them with YME1L1)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Identification and characterization of YME1L1, a novel paraplegin- related gene. (PubMed id 10843804)1, 2, 9 Coppola M.... Incerti B. (2000)
    2. YME1L controls the accumulation of respiratory chain subunits and is required for apoptotic resistance, cristae morphogenesis and cell proliferation. (PubMed id 22262461)1, 2 Stiburek L.... Zeman J. (2012)
    3. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
    4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    5. The DNA sequence and comparative analysis of human chromosome 10. (PubMed id 15164054)1, 2 Deloukas P.... Rogers J. (2004)
    6. The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment. (PubMed id 12975309)1, 2 Clark H.F.... Gray A.M. (2003)
    7. The human homologue of the yeast mitochondrial AAA metalloprotease Yme1p complements a yeast yme1 disruptant. (PubMed id 10930580)1, 9 Shah Z.H....Jacobs H.T. (2000)
    8. Metalloprotease-mediated OPA1 processing is modulated by the mitochondrial membrane potential. (PubMed id 18076378)2, 9 Guillery O.... Rojo M. (2008)
    9. A census of human soluble protein complexes. (PubMed id 22939629)1 Havugimana P.C....Emili A. (2012)
    10. Initial characterization of the human central proteome. (PubMed id 21269460)2 Burkard T.R.... Colinge J. (2011)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 10730 HGNC: 12843 AceView: YME1L1 Ensembl:ENSG00000136758 euGenes: HUgn10730
    ECgene: YME1L1 H-InvDB: YME1L1

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for YME1L1 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for YME1L1 gene:
    Search GeneIP for patents involving YME1L1

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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    GeneCards Homepage - Last full update: 19 Mar 2013 - Incrementals: 21 Mar 2013 , 15 Apr 2013 , 26 Apr 2013

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