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YME1L1 Gene

protein-coding   GIFtS: 59
GCID: GC10M027439

YME1-Like 1 ATPase

(Previous names: YME1 (S.cerevisiae)-like 1, YME1-like 1 (S. cerevisiae))
  See YME1L1-related disease
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
YME1-Like 1 ATPase1 2     ATP-Dependent Metalloprotease FtsH1 Homolog2
PAMP2 3 5     ATP-Dependent Metalloprotease YME1L12
YME1L2 3 5     ATP-Dependent Zinc Metalloprotease YME1L12
Presenilin-Associated Metalloprotease2 3     meg-42
YME1-Like Protein 12 3     EC 3.4.24.-3
YME1 (S.Cerevisiae)-Like 11     FTSH13
YME1-Like 1 (S. Cerevisiae)1     Meg-43
FTSH2     ATP-Dependent Metalloprotease FtsH13
MEG42     EC 3.4.248

External Ids:    HGNC: 128431   Entrez Gene: 107302   Ensembl: ENSG000001367587   OMIM: 6074725   UniProtKB: Q96TA23   

Export aliases for YME1L1 gene to outside databases

Previous GC identifers: GC10M027134 GC10M027549 GC10M027403 GC10M027068


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for YME1L1 Gene:
The protein encoded by this gene is the human ortholog of yeast mitochondrial AAA metalloprotease, Yme1p. It is
localized in the mitochondria and can functionally complement a yme1 disruptant yeast strain. It is proposed that
this gene plays a role in mitochondrial protein metabolism and could be involved in mitochondrial pathologies.
Three transcript variants encoding different isoforms have been found for this gene. (provided by RefSeq, Dec
2011)

GeneCards Summary for YME1L1 Gene:
YME1L1 (YME1-like 1 ATPase) is a protein-coding gene. Diseases associated with YME1L1 include pulmonary valve insufficiency. GO annotations related to this gene include nucleoside-triphosphatase activity and metalloendopeptidase activity.

UniProtKB/Swiss-Prot: YMEL1_HUMAN, Q96TA2
Function: Putative ATP-dependent protease which plays a role in mitochondrial protein metabolism. Ensures cell
proliferation, maintains normal cristae morphology and complex I respiration activity, promotes antiapoptotic
activity and protects mitochondria from the accumulation of oxidatively damaged membrane proteins. Requires to
control the accumulation of nonassembled respiratory chain subunits (NDUFB6, OX4 and ND1). Seems to act in the
processing of OPA1

Gene Wiki entry for YME1L1 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000010.10  NC_018921.2  NT_008705.17  
Regulatory elements:
   Regulatory transcription factor binding sites in the YME1L1 gene promoter:
         ATF-2   c-Jun   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidYME1L1 promoter sequence
   Search Chromatin IP Primers for YME1L1

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat YME1L1


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 10p14   Ensembl cytogenetic band:  10p12.1   HGNC cytogenetic band: 10p14

YME1L1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
YME1L1 gene location

GeneLoc information about chromosome 10         GeneLoc Exon Structure

GeneLoc location for GC10M027439:  view genomic region     (about GC identifiers)

Start:
27,399,383 bp from pter      End:
27,444,195 bp from pter
Size:
44,813 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., and/or eBioscience,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., and/or eBioscience, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: YMEL1_HUMAN, Q96TA2 (See protein sequence)
Recommended Name: ATP-dependent zinc metalloprotease YME1L1  
Size: 773 amino acids; 86455 Da
Cofactor: Binds 1 zinc ion per subunit (Potential)
Subunit: Exists in several complexes of 600-1100 kDa
Secondary accessions: B4DNM1 D3DRV8 D3DRV9 Q5T8D9 Q9H1Q0 Q9UMR9
Alternative splicing: 3 isoforms:  Q96TA2-1   Q96TA2-2   Q96TA2-3   (Mutagenesis of Glu-543 to Gln does not complement excessive accumulation of subunits (NDUFB6, COX4,ND1) due to YME1 deletion mutant. Probably has no ATPase activity)

Explore the universe of human proteins at neXtProt for YME1L1: NX_Q96TA2

Explore proteomics data for YME1L1 at MOPED

Post-translational modifications: 

  • Ubiquitination2 at Lys237, Lys253, Lys258, Lys269, Lys363, Lys385, Lys446, Lys524, Lys568
  • Modification sites at PhosphoSitePlus
  • Selected DME Specific Peptides for YME1L1 (Q96TA2) (see all 8)
     EMFVGVG  AKANAPC  GRTEILK  QTINQLL 


    See YME1L1 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (3 alternative transcripts): 
    NP_001240795.1  NP_055078.1  NP_647473.1  

    ENSEMBL proteins: 
     ENSP00000318480   ENSP00000365184   ENSP00000473557   ENSP00000398713   ENSP00000379590  
     ENSP00000473302   ENSP00000365139  

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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    AATP: ATPases / AAA-type

    Selected InterPro protein domains (see all 6):
     IPR003959 ATPase_AAA_core
     IPR005936 FtsH
     IPR003960 ATPase_AAA_CS
     IPR000642 Peptidase_M41
     IPR027417 P-loop_NTPase

    Graphical View of Domain Structure for InterPro Entry Q96TA2

    ProtoNet protein and cluster: Q96TA2

    2 Blocks protein domains:
    IPB000642 Peptidase M41
    IPB003960 AAA-protein subdomain


    UniProtKB/Swiss-Prot: YMEL1_HUMAN, Q96TA2
    Similarity: In the N-terminal section; belongs to the AAA ATPase family
    Similarity: In the C-terminal section; belongs to the peptidase M41 family


    Find genes that share domains with YME1L1           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: YMEL1_HUMAN, Q96TA2
    Function: Putative ATP-dependent protease which plays a role in mitochondrial protein metabolism. Ensures cell
    proliferation, maintains normal cristae morphology and complex I respiration activity, promotes antiapoptotic
    activity and protects mitochondria from the accumulation of oxidatively damaged membrane proteins. Requires to
    control the accumulation of nonassembled respiratory chain subunits (NDUFB6, OX4 and ND1). Seems to act in the
    processing of OPA1

         Enzyme Numbers (IUBMB): EC 3.4.24.-1 EC 3.4.242

         Gene Ontology (GO): 5 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000166nucleotide binding ----
    GO:0004222metalloendopeptidase activity IEA--
    GO:0005524ATP binding IEA--
    GO:0017111nucleoside-triphosphatase activity IEA--
    GO:0046872metal ion binding IEA--
         
    Find genes that share ontologies with YME1L1           About GenesLikeMe


    Phenotypes:
         2 GenomeRNAi human phenotypes for YME1L1:
     Increased cell number in G1, s  Synthetic lethal with Ras 

         1 MGI phenotypic allele for Yme1l1 (no phenotypes)

    Find genes that share phenotypes with YME1L1           About GenesLikeMe

    Animal Models:
       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for YME1L1
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    Selected qRT-PCR Assays for microRNAs that regulate YME1L1 (see all 35):
    hsa-miR-548j hsa-miR-429 hsa-miR-124 hsa-miR-548a-5p hsa-miR-548d-5p hsa-miR-506 hsa-miR-200b hsa-miR-509-3-5p
    SwitchGear 3'UTR luciferase reporter plasmidYME1L1 3' UTR sequence
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    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    YMEL1_HUMAN, Q96TA2: Mitochondrion inner membrane
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    mitochondrion5
    chloroplast3
    cytosol3
    plasma membrane2
    extracellular1
    nucleus1
    peroxisome1

    Gene Ontology (GO): 4 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005739mitochondrion ----
    GO:0005743mitochondrial inner membrane IDA--
    GO:0016020membrane ----
    GO:0016021integral component of membrane IEA--

    Find genes that share ontologies with YME1L1           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for YME1L1
    Interactions:

        GeneGlobe Interaction Network for YME1L1

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for YME1L1 (Q96TA22, 3 ENSP000003184804) via UniProtKB, MINT, STRING, and/or I2D (see all 471)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    AFG3L2Q9Y4W62, 3, ENSP000002691434MINT-8079030 I2D: score=1 STRING: ENSP00000269143
    ATP5BP065762, 3, ENSP000002620304MINT-8079030 I2D: score=1 STRING: ENSP00000262030
    ATP5C1P365422, 3, ENSP000003491424MINT-8079030 I2D: score=1 STRING: ENSP00000349142
    UQCRFS1P479852, 3, ENSP000003063974MINT-8079030 I2D: score=1 STRING: ENSP00000306397
    HSPA9P386462, 3MINT-8079030 I2D: score=1 
    About this table

    Gene Ontology (GO): 4 biological process terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006508proteolysis ----
    GO:0006515misfolded or incompletely synthesized protein catabolic process IMP--
    GO:0007005mitochondrion organization IMP--
    GO:0008283cell proliferation IMP--

    Find genes that share ontologies with YME1L1           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for YME1L1 (YMEL1)

    1 Novoseek inferred chemical compound relationship for YME1L1 gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    atp 10.1 3 15803409 (2), 15047485 (1)



    Find genes that share compounds with YME1L1           About GenesLikeMe



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for YME1L1 gene (4 alternative transcripts): 
    NM_001253866.1  NM_014263.3  NM_139312.2  NM_139313.1  

    Unigene Clusters for YME1L1:

    YME1-like 1 (S. cerevisiae)
    Hs.74647  [show with all ESTs], Hs.499145  [show with all ESTs]
    Unigene Representative Sequences: X73617, BC024215
    8 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000326799(uc001iti.3) ENST00000376016(uc001itj.3 uc010qdl.2)
    ENST00000463270 ENST00000491542 ENST00000427324 ENST00000396296 ENST00000477432(uc001itk.2)
    ENST00000375972
    miRNA
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    Selected qRT-PCR Assays for microRNAs that regulate YME1L1 (see all 35):
    hsa-miR-548j hsa-miR-429 hsa-miR-124 hsa-miR-548a-5p hsa-miR-548d-5p hsa-miR-506 hsa-miR-200b hsa-miR-509-3-5p
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      QuantiTect SYBR Green Assays in human, mouse, rat YME1L1
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    Additional mRNA sequence: 

    AF070656.1 AF151782.1 AJ132637.1 AK001259.1 AK022930.1 AK291292.1 AK297973.1 AK309708.1 
    AK314372.1 AY358484.1 BC007795.2 BC019602.1 BC023507.2 BC024032.2 BC024215.1 

    Selected DOTS entries (see all 117):

    DT.75111939  DT.100840954  DT.416839  DT.91929548  DT.100645914  DT.95070986  DT.102840523  DT.97845698 
    DT.75187431  DT.96086423  DT.91863912  DT.120744259  DT.102845570  DT.95189905  DT.92338901  DT.95228736 
    DT.91659769  DT.95160576  DT.97847759  DT.75187239  DT.91641502  DT.95292892  DT.95160588  DT.95363549 

    Selected AceView cDNA sequences (see all 530):

    BI830135 BM756343 BQ230570 BC023507 BU155006 BQ717013 AL708518 BX426567 
    AL709289 CR611030 AW467583 BQ423781 BU686181 NM_014263 BX406565 AA926753 
    AA452392 BI856907 AL701495 BU156440 F03137 CB119538 BM980852 BF793595 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    YME1L1 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: CTGTTATAGG
    YME1L1 Expression
    About this image

    YME1L1 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    YME1L1 Protein Expression

    SOURCE GeneReport for Unigene clusters: Hs.74647 Hs.499145

    UniProtKB/Swiss-Prot: YMEL1_HUMAN, Q96TA2
    Tissue specificity: High expression in cardiac and skeletal muscle mitochondria

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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for YME1L1

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of eukaryotes.

    Orthologs for YME1L1 gene from Selected species (see all 19)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Yme1l11 , 5 YME1-like 1 (S. cerevisiae)1, 5 89.09(n)1
    94.13(a)1
      2 (15.24 cM)5
    273771  NM_013771.51  NP_038799.11 
     231563695 
    chicken
    (Gallus gallus)
    Aves YME1L11 YME1-like 1 (S. cerevisiae) 77.08(n)
    81.37(a)
      428418  NM_001031512.1  NP_001026683.1 
    lizard
    (Anolis carolinensis)
    Reptilia YME1L16
    YME1-like 1 ATPase
    88(a)
    1 ↔ 1
    6(14472149-14492086)
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia yme1l11 YME1-like 1 ATPase 74.83(n)
    82.8(a)
      100494966  XM_002933140.2  XP_002933186.2 
    zebrafish
    (Danio rerio)
    Actinopterygii BI897858.12   -- 94.37(n)    BI897858.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta CG34991 , 3 ATP-dependent peptidase3
    CG34991
    54(a)3
    57.07(n)1
    56.12(a)1
      59B43
    376361  NM_001274213.11  NP_001261142.11 
    worm
    (Caenorhabditis elegans)
    Secernentea M03C11.53
    ymel-11
    ATP-binding protein (AAA protein family
    member)3
    ymel-11
    55(a)3
    58.55(n)1
    53.27(a)1
      III(10487806-10493012)3
    1764601  NM_066897.31  NP_499298.21 
    baker's yeast
    (Saccharomyces cerevisiae)
    Saccharomycetes YME1(YPR024W)4 Catalytic subunit of the mitochondrial inner membrane more   --   16(610481-612724) 856135  NP_015349.1 
    Alicante grape
    (Vitis vinifera)
    eudicotyledons CF519047.12   -- 75.52(n)    CF519047.1 
    rice
    (Oryza sativa)
    Liliopsida NM_193606.12   -- 72.29(n)    NM_193606.1 


    ENSEMBL Gene Tree for YME1L1 (if available)
    TreeFam Gene Tree for YME1L1 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for YME1L1 gene
    8 SIMAP similar genes for YME1L1 using alignment to 6 protein entries:     YMEL1_HUMAN (see all proteins):
    FTSH    DKFZp666D103    PSMC1    AFG3L2    SPG7    PSMC5
    PSMC2    PSMC6

    Find genes that share paralogs with YME1L1           About GenesLikeMe


    4 Pseudogenes.org Pseudogenes for YME1L1
    PGOHUM00000248000 PGOHUM00000234779 PGOHUM00000246193 PGOHUM00000240299


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for YME1L1 (see all 988)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 10 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs677157511,2
    C--27078553(-) GTTTT-/TAAAA 
            
    TAAAT
    3 -- int11Minor allele frequency- TAAAA:0.00NA 2
    rs348019501,2
    C--27099600(+) ATATA-/TAAAATT 3 -- int12Minor allele frequency- TA:0.00NA CSA 4
    rs1442130521,2
    C--27398605(+) TCAAG-/ATCC  
            
    ATCTG
    3 -- ds50010--------
    rs604717611,2
    C--27398608(+) AGATC-/CATC  
            
    TGATA
    3 -- ds50010--------
    rs1405227491,2
    --27398774(+) ATGATC/GTAACT 3 -- ds50010--------
    rs1456153311,2
    C--27398883(+) TCCTAC/TATTGC 3 -- ds50010--------
    rs110155361,2
    C,F--27399003(+) TCTAAT/CTGTGG 3 -- ds50018Minor allele frequency- C:0.29NA WA CSA EA 367
    rs1846547911,2
    --27399024(+) ACACAC/TAACAT 3 -- ds50010--------
    rs1466491151,2
    --27399082(+) CTCAAC/TAAATA 3 -- ut310--------
    rs74778061,2
    C,F,A,H--27399117(+) GACTTT/CATCAA 3 -- ut3120Minor allele frequency- C:0.35NS EA NA WA 2230

    HapMap Linkage Disequilibrium report for YME1L1 (27399383 - 27444195 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 2 variations for YME1L1:    About this table    
    Variant IDTypeSubtypePubMed ID
    esv2422253CNV Deletion17116639
    esv2664616CNV Deletion23128226

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing YME1L1
    DNA2.0 Custom Variant and Variant Library Synthesis for YME1L1

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 607472    OMIM disorders: --

    1 disease for YME1L1:    
    About MalaCards
    pulmonary valve insufficiency

    1 disease from the University of Copenhagen DISEASES database for YME1L1:
    Pulmonary valve insufficiency

    Find genes that share disorders with YME1L1           About GenesLikeMe

    Genetic Association Database (GAD): YME1L1
    Human Genome Epidemiology (HuGE) Navigator: YME1L1 (2 documents)

    Export disorders for YME1L1 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for YME1L1 gene, integrated from 10 sources (see all 52):
    (articles sorted by number of sources associating them with YME1L1)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. YME1L controls the accumulation of respiratory chain subunits and is required for apoptotic resistance, cristae morphogenesis and cell proliferation. (PubMed id 22262461)1, 2, 3 Stiburek L.... Zeman J. (Mol. Biol. Cell 2012)
    2. Identification and characterization of YME1L1, a novel paraplegin- related gene. (PubMed id 10843804)1, 2, 9 Coppola M.... Incerti B. (Genomics 2000)
    3. Genetic variants in nuclear-encoded mitochondrial genes influence AIDS progression. (PubMed id 20877624)1, 4 Hendrickson S.L....O'Brien S.J. (PLoS ONE 2010)
    4. A scan of chromosome 10 identifies a novel locus showing strong association with late-onset Alzheimer disease. (PubMed id 16385451)1, 4 Grupe A....Goate A. (Am. J. Hum. Genet. 2006)
    5. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (Nat. Genet. 2004)
    6. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    7. The DNA sequence and comparative analysis of human chromosome 10. (PubMed id 15164054)1, 2 Deloukas P.... Rogers J. (Nature 2004)
    8. The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment. (PubMed id 12975309)1, 2 Clark H.F.... Gray A.M. (Genome Res. 2003)
    9. The human homologue of the yeast mitochondrial AAA metalloprotease Yme1p complements a yeast yme1 disruptant. (PubMed id 10930580)1, 9 Shah Z.H....Jacobs H.T. (FEBS Lett. 2000)
    10. Metalloprotease-mediated OPA1 processing is modulated by the mitochondrial membrane potential. (PubMed id 18076378)2, 9 Guillery O.... Rojo M. (Biol. Cell 2008)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 10730 HGNC: 12843 AceView: YME1L1 Ensembl:ENSG00000136758 euGenes: HUgn10730
    ECgene: YME1L1 H-InvDB: YME1L1

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for YME1L1 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for YME1L1 gene:
    Search GeneIP for patents involving YME1L1

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, eBioscience, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
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