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YLPM1 Gene

protein-coding   GIFtS: 44

GC14P074299
YLP motif containing 1
(Previous name: chromosome 14 open reading frame 170 )
Symbol approved by the HUGO Gene Nomenclature Committee (HGNC) database
(Previous symbol: C14orf170)
Services    
(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc , and/or 7Ensembl, 8miRBase)
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Aliases
C14orf170 2, 3
ZAP 1, 2
ZAP113 3
ZAP3 2, 3
Descriptions
Nuclear protein ZAP3 3
YLP motif containing 1 2
chromosome 14 open reading frame 170 1
nuclear protein ZAP 2
External Ids
HGNC: 177981
Entrez Gene: 562522
UniProtKB: P497503
Ensembl: ENSG000001195967
Search outside databases for aliases for YLPM1 gene

(According to Entrez Gene, Wikipedia's Gene Wiki,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Gene Wiki entry for YLPM1
(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 36),
and/or miRBase,
Genomic Views according to UCSC and Ensembl, Transcription factor binding sites according to SABiosciences)
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Genomic View:
UCSC Golden Path with GeneCards custom track

 Transcription factor binding sites upstream to the YLPM1 gene  

Entrez Gene cytogenetic band: 14q24.3   Ensembl cytogenetic band:  14q24.3   HGNC cytogenetic band: 14q24.3

YLPM1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)

GeneLoc gene densities for chromosome 14         GeneLoc Exon Structure

GeneLoc location for GC14P074299:     (about GC identifiers)

Start:
74,299,822 bp from pter
End:
74,373,766 bp from pter
Size:
73,945 bases
Orientation:
plus strand
RefSeq DNA sequence:
NC_000014.7  NT_026437.11  
(According to 1UniProtKB, and/or Ensembl, Phosphorylation sites according to 2Phosphosite, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Enzo Life Sciences, Abnova, OriGene and/or, Abcam,
Biochemical Assays by Invitrogen, Millipore, R&D Systems, Cell Signaling Technology, and/or Enzo Life Sciences, Ontologies according to Gene Ontology Consortium 01 Apr 2009 and Entrez Gene, Antibodies by Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Cell Signaling Technology, Abcam, Abnova, and/or Novus Biologicals)
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UniProtKB/Swiss-Prot: YLPM1_HUMAN, P49750 (See protein sequence)
Recommended Name: YLP motif-containing protein 1  
Size: 1951 amino acids; 219985 Da
Subcellular location: Nucleus speckle (By similarity)
Sequence caution: Sequence=AAC42008.1; Type=Frameshift; Positions=1723;
Secondary accessions: P49752 Q96I64 Q9P1V7
Alternative splicing: 3 isoforms:  P49750-1   P49750-2   P49750-3   

Post-translational modifications:

  • View phosphorylation sites using PhosphoSite2


  • REFSEQ proteins: NP_062535.2  

    ENSEMBL proteins: 
    ENSP00000238571 ENSP00000324463 


    Human Recombinant Proteins 
    Browse Drug Discovery Central at Invitrogen for human recombinant proteins
    Browse Purified and Recombinant Proteins at Millipore
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    Browse Abcam for Recombinant Proteins
    Browse Abnova for Human Recombinant Proteins
                    Browse Origene for full length recombinant human proteins expressed in human HEK293 cells 

    3 Gene Ontology (GO) cellular component terms (links to tree view):

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005575 cellular_component ND--
    GO:0005634 nucleus IEA--
    GO:0016607 nuclear speck IEA--
    About this table

    Antibodies for YLPM1: 
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    Assays for YLPM1: 
    Browse Invitrogen for biochemical assays
    Browse Kits and Assays available from Millipore
    Browse R&D Systems for biochemical assays
    Browse biochemical assays available from Enzo Life Sciences

    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section

    1 InterPro domain/family:
     IPR004019 YLP_motif


       GeneDecks  YLPM1 for the domains selected above  
    About GeneDecksing

    Graphical View of Domain Structure for InterPro Entry P49750

    ProtoNet protein and cluster: P49750

    (According to MGI Jun 06 2009, UniProtKB, IUBMB,and/or Genatlas,
    shRNA from OriGene, Sigma-Aldrich, RNAi from Sigma-Aldrich,
    RNAi Products, Clones, and Q-PCR Products from Invitrogen, Millipore, OriGene, and/or Abnova, siRNAs from Applied Biosystems, SYBR primers from OriGene, Cell-based Assays from Millipore, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
    About This Section

    Inhib.
    RNA:
    Invitrogen RNAi Products for gene knock-down (YLPM1)
    Browse for Gene Knock-down Tools from Millipore
    Browse Abnova for Chimera RNAi Products
                    Browse Origene for 29mer shRNA kit in GFP-retroviral vector

                  Applied Biosystems Silencer® siRNAs for YLPM1

                  Sigma-Aldrich siRNA for YLPM1  
                         Browse shRNA at Sigma-Aldrich  
                         Explore Sigma-Aldrich super-pooled esiRNAs  

    Clones:Browse Clone Ranger at Invitrogen for clones
    Browse Clones for the Expression of Recombinant Proteins Available from Millipore
                  OriGene GFP tagged cDNA clone in CMV expression vector: NM_019589
                                     Myc/DDK tagged cDNA clone in CMV expression vector: NM_019589
                                     untagged cDNA clone in CMV expression vector: NM_019589 

    Primers: Browse Quantitative PCR Central at Invitrogen for Q-PCR LUX™ Primers
                  OriGene genome-wide validated SYBR primer pairs: NM_019589

    1 Gene Ontology (GO) molecular function term (links to tree view):

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003674 molecular_function ND--
    About this table

    (Pathways according to Invitrogen (maps by GeneGo), Millipore, Cell Signaling Technology, Sigma-Aldrich, KEGG and/or UniProtKB,
    Sets of similar genes according to GeneDecks, Proteins Network according to SABiosciences, Interactions according to 1UniProtKB, 2MINT, and/or 3STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
    About This Section


      --

    1 Gene Ontology (GO) biological process term (links to tree view):

    GO IDQualified GO termEvidencePubMed IDs
    GO:0008150 biological_process ND--
    About this table
    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, Sigma-Aldrich, Tocris Bioscience, and/or Novoseek and Drugs according to Enzo Life Sciences and/or PharmGKB)
    About This Section

    Browse drugs & compounds from Enzo Life Sciences
    Browse Small Molecules at Sigma-Aldrich

    Browse Tocris compounds for YLPM1

    (GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 219 Homo sapiens; Jun 2 2009) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView,
    non coding RNAs according to RNAdb,
    ESTs according to GeneTide,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from Invitrogen, Millipore, and/or Abnova,
    siRNAs from Applied Biosystems, Sigma-Aldrich,
    shRNA from Sigma-Aldrich, OriGene,
    Tagged/untagged cDNA clones from OriGene,
    Expression Assays from Applied Biosystems)
    About This Section

    Inhib.
    RNA:
    Invitrogen RNAi Products for gene knock-down (YLPM1)
    Browse for Gene Knock-down Tools from Millipore
    Browse Abnova for Chimera RNAi Products
                    Browse Origene for 29mer shRNA kit in GFP-retroviral vector

                  Sigma-Aldrich siRNA for YLPM1  
                         Browse shRNA at Sigma-Aldrich  
                         Explore Sigma-Aldrich super-pooled esiRNAs  

    Applied Biosystems Silencer® siRNAs: 

    NM_019589  

    REFSEQ mRNAs for YLPM1 gene: 

    NM_019589.2   

    Applied Biosystems TaqMan ® Gene Expression Assays: 

    NM_019589  

                  OriGene GFP tagged cDNA clone in CMV expression vector: NM_019589
                                     Myc/DDK tagged cDNA clone in CMV expression vector: NM_019589
                                     untagged cDNA clone in CMV expression vector: NM_019589 

    Additional cDNA sequence: 

    AK090435.1 AK095760.1 AK096592.1 AK297582.1 BC007792.1 BC023570.2 BC044636.1 BX647164.1 
    L40396.1 L40400.1 L40403.1 

    21 DOTS entries:

    DT.86821316  DT.97837477  DT.100036129  DT.403807  DT.100796385  DT.95298666  DT.315813  DT.95250763 
    DT.40288195  DT.454492  DT.97822380  DT.315812  DT.91826700  DT.120777942  DT.448284  DT.95335030 
    DT.97770738  DT.315811  DT.97809341  DT.99929431  DT.120777936 

    24/337 AceView cDNA sequences (see all 337 ):

    BM987348 BQ215629 AA975246 BQ005188 BM973535 AA808393 AA983226 AI687263 
    AA732626 AV713690 AI095196 AA610599 AA829415 BU733504 AU142662 BM982466 
    AI147227 AL601230 AW449505 BC007792 AA190600 BX090800 AA633087 CD722452 

    highest scoring ESTs for YLPM1:

    L40396 AA181552 AA190600 AA191147 AA229821 AA402877 AA418612 AA463706 AA463969 AA514905 

    Unigene Cluster for YLPM1:

    YLP motif containing 1
    Hs.531111  [show with all ESTs]
    Unigene Representative Sequence: NM_019589


    GeneLoc Exon Structure

    2 Ensembl transcripts including schematic representations:
    ENST00000238571  ENST00000325680  
    (Experimental results according to 1GeneNote and GNF BioGPS,
    probe sets-to-genes annotations according to 2GeneAnnot , 3GeneTide , Sets of similar genes according to GeneDecks, Electronic Northern calculations according to data from UniGene (Build 219 Homo sapiens), SAGE tags according to CGAP, plus additional links to SOURCE, and/or GNF BioGPS, and/or EXPOLDB, and/or UniProtKB,
    Expression Assays from Applied Biosystems )
    About This Section

    YLPM1 expression in normal and diseased human tissues

     Applied Biosystems TaqMan ® Gene Expression Assays for YLPM1

    1 / 2 / 3

    10 probe-sets matching YLPM1 gene


    Affymetrix
    probe-set
    Array  GeneAnnot data GeneNote data GeneTide data
    # genes Sensitivity Specificity Correlation Length Gb_Accession Consensus Uniqueness Score Rank

    33927_i_at2, 3 U95-A 1 1.00 1.00 0.76 0.80 L40396 1.00 1.00 1.00 1

    33926_at2, 3 U95-A 1 1.00 1.00 0.84 1.23 L40403 0.80 1.00 0.91 1

    33928_r_at2, 3 U95-A 1 1.00 1.00 -0.02 0.44 L40396 1.00 1.00 1.00 1

    36385_at2, 3 U95-A 2 1.00 0.97 0.50 0.21 L40400 0.80 1.00 0.91 1

    212787_at2, 3 U133-A 1 1.00 1.00 -- -- AI952986 0.60 1.00 0.82 1

    214659_x_at2 U133-A 1 1.00 1.00 -- -- -- -- -- -- --

    214713_at2, 3 U133-A 1 0.82 1.00 -- -- AI703162 0.40 1.00 0.76 1

    212787_at2 U133Plus2 1 1.00 1.00 -- -- -- -- -- -- --

    214659_x_at2 U133Plus2 1 1.00 1.00 -- -- -- -- -- -- --

    214713_at2 U133Plus2 1 0.82 1.00 -- -- -- -- -- -- --
    About this table
    Data from (Publications) and GNF BioGPS
        About these images
    About these images

    CGAP SAGE TAG: --

    SOURCE GeneReport for Unigene cluster: Hs.531111

    Expression variation in blood from EXPOLDB for YLPM1

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD and/or 5MGI Jun 06 2009, with possible further links to Flybase and/or WormBase, Gene Trees according to Ensembl)
    About This Section


    Orthologs for YLPM1 gene from 5/8 species (see all 8 )
    Organism Gene Locus Description Human
    Similarity
    NCBI accessions
    chimpanzee
    (Pan troglodytes)
    YLPM11   -- YLP motif containing 1 99.72(n)
    99.81(a)
    453038  XM_510067.2  XP_510067.2 
    mouse
    (Mus musculus)
    Ylpm15 12 YLP motif containing 1   -- CA980613 
    zebrafish
    (Danio rerio)
    570553412   --   -- 75.87(n)  57055341 
    African clawed frog
    (Xenopus laevis)
    CA792944.12   --   -- 76.95(n)  CA792944.1 
    tropical clawed frog
    (Silurana tropicalis)
    1419959892   --   -- 78.66(n)  141995989 
    About this table        Species with no ortholog for YLPM1

    ENSEMBL Gene Tree for YLPM1
    (Paralogs according to 1HomoloGene
    and 2Ensembl, Pseudogenes according to 3Pseudogene.org)
    About This Section

      --
    (According to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, and UniProtKB, Linkage Disequilibrium by HapMap, Genotyping Reagents from Applied Biosystems)
    About This Section


    10/302 NCBI SNPs in YLPM1 are shown (see all 302 )
    (Click for Applied Biosystems TaqMan ® Genotyping Assay)  (see all 111)
    ABGenomic DataTranscription DataAllele Frequencies
    SNP IDValidChr 14 posSequenceRecsAA
    Chg
    TypeMoreRecsAllele
    freq
    PopTotal
    sample
    More
    ------------
    rs128892771,2
    C,F,H74299129(+) GATTTA/TTATGT 1 -- ng517Minor allele frequency- T:0.35EU EA WA NA 496
    rs71508791,2
    H74353660(+) TTTGGC/GTGAAA 1 A/G mis1 ese34Minor allele frequency- G:0.00EU EA WA 416
    --
    rs71592051,2
    A74372546(+) TGGCTG/TTTTCT 1 -- ut31 ese30--------
    --
    rs71463951,2
    C74298400(+) cctggA/Ctactt 1 -- ng510--------
    --
    rs177827551,2
    F74374068(+) TGCCAA/GTGAAA 1 -- ng313Minor allele frequency- G:0.19NA 142
    rs101354511,2
    A74298940(+) CCCCCA/CCACAC 1 -- ng51 tfbs30--------
    rs23028351,2
    A,C,F,H74349214(+) CCACCG/AGGCCG 1 P/P syn1 ese38Minor allele frequency- A:0.03EA EU WA NA 2044
    rs22874011,2
    C,F,H74318422(+) CAAGGG/TATACC 1 G/G syn112Minor allele frequency- N:0.00NA EU EA WA 1044
    rs23028341,2
    C,F,H74349148(+) CAGCCA/TCCTCC 1 P/P syn16Minor allele frequency- T:0.21EA MN EU WA 2096
    rs128855271,2
    F74300590(+) TCGCAA/GTCCTA 1 Q/Q syn12Minor allele frequency- G:0.04NA 182
    About this table

    HapMap Linkage Disequilibrium images for YLPM1 (up to first 250kb)

    (in which this Gene is Involved, According to OMIM, UniProtKB, PharmGKB, Genatlas, GeneTests, Blood group antigen gene mutations by BGMUT, HGMD, GAD, HuGE Navigator, BCGD, and/or TGDB.)
    About This Section

      --

    (Possibly Related Articles in Doctor's Guide)
    About This Section

      --

    (in PubMed. Associations of this gene to articles via 1Novoseek, 2HGNC, 3Entrez Gene, 4UniProtKB/Swiss-Prot, 5UniProtKB/TrEMBL, 6GAD, and/or 7PharmGKB)
    About This Section

    10/13 PubMed articles for YLPM1 gene (see all 13 ):
    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section

     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)
    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, and/or H-InvDB)
    About This Section

    Entrez Gene: 56252 HGNC: 17798 AceView: YLPM1 Ensembl:ENSG00000119596 euGenes: HUgn56252
    ECgene: YLPM1 H-InvDB: YLPM1
    (According to HUGE)
    About This Section

      --
    (According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section

      --
    (Available from WIS Yeda, Salk, Tufts)
    About This Section

      --
    (Reagents available from Applied Biosystems, Antibodies and assays by Cell Signaling Technology, Abcam, Novus Biologicals,
    Sigma-Aldrich, R&D Systems, Millipore, Abnova, and/or Invitrogen, Clones available from OriGene,and/or Invitrogen, Drugs and/or compounds by Sigma-Aldrich,
    Enzo Life Sciences, and/or Tocris Bioscience)
    About This Section



    Products for YLPM1:
     TaqMan ® Gene Expression Assays
     TaqMan ® Genotyping Assays
      Free SNP selection tool



      Invitrogen iPath Pathways  Invitrogen BLOCK-iT™ RNAi
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     Predesigned and custom siRNAs for YLPM1 Browse antibodies at Sigma-Aldrich
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     Search Novus for antibodies for YLPM1

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