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YLPM1 Gene

protein-coding GIFtS: 44

GC14P074299

YLP motif containing 1
(Previous name: chromosome 14 open reading frame 170 )
Symbol approved by the HUGO Gene Nomenclature Committee (HGNC) database
(Previous symbol: C14orf170)

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc , and/or ⁷Ensembl, ⁸miRBase)
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Aliases
C14orf170 ^², ³
ZAP ^¹, ²
ZAP113 ^³
ZAP3 ^², ³

Descriptions
Nuclear protein ZAP3 ^³
YLP motif containing 1 ^²
chromosome 14 open reading frame 170 ^¹
nuclear protein ZAP ^²

External Ids
HGNC: 17798¹
Entrez Gene: 56252²
UniProtKB: P49750³
Ensembl: ENSG00000119596⁷

Search outside databases for aliases for YLPM1 gene

(According to Entrez Gene, Wikipedia's Gene Wiki,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Gene Wiki entry for YLPM1

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 36),
and/or miRBase,
Genomic Views according to UCSC and Ensembl, Transcription factor binding sites according to SABiosciences)
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Genomic View:

UCSC Golden Path with GeneCards custom track

Transcription factor binding sites upstream to the YLPM1 gene

Entrez Gene cytogenetic band: 14q24.3 Ensembl cytogenetic band: 14q24.3 HGNC cytogenetic band: 14q24.3

YLPM1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)

GeneLoc gene densities for chromosome 14 GeneLoc Exon Structure

GeneLoc location for GC14P074299: (about GC identifiers)

Start:	74,299,822 bp from pter
End:	74,373,766 bp from pter
Size:	73,945 bases
Orientation:	plus strand

RefSeq DNA sequence:

NC_000014.7 NT_026437.11

(According to ¹UniProtKB, and/or Ensembl, Phosphorylation sites according to ²Phosphosite, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Enzo Life Sciences, Abnova, OriGene and/or, Abcam,
Biochemical Assays by Invitrogen, Millipore, R&D Systems, Cell Signaling Technology, and/or Enzo Life Sciences, Ontologies according to Gene Ontology Consortium 01 Apr 2009 and Entrez Gene, Antibodies by Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Cell Signaling Technology, Abcam, Abnova, and/or Novus Biologicals)
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UniProtKB/Swiss-Prot: YLPM1_HUMAN, P49750 (See protein sequence)

Recommended Name: YLP motif-containing protein 1

Size: 1951 amino acids; 219985 Da

Subcellular location: Nucleus speckle (By similarity)

Sequence caution: Sequence=AAC42008.1; Type=Frameshift; Positions=1723;

Secondary accessions: P49752 Q96I64 Q9P1V7

Alternative splicing: 3 isoforms: P49750-1 P49750-2 P49750-3

Post-translational modifications:

View phosphorylation sites using PhosphoSite²

REFSEQ proteins: NP_062535.2

ENSEMBL proteins:

ENSP00000238571 ENSP00000324463

Human Recombinant Proteins

	Browse Drug Discovery Central at Invitrogen for human recombinant proteins
	Browse Purified and Recombinant Proteins at Millipore
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	Browse Abcam for Recombinant Proteins
	Browse Abnova for Human Recombinant Proteins

Browse Origene for full length recombinant human proteins expressed in human HEK293 cells

3 Gene Ontology (GO) cellular component terms (links to tree view):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005575	cellular_component	ND	--
GO:0005634	nucleus	IEA	--
GO:0016607	nuclear speck	IEA	--

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Antibodies for YLPM1:

	Browse Antibodies Central at Invitrogen
	Browse Millipore's Extensive Line of Mono- and Polyclonal Antibodies
	Browse Antibodies at Sigma-Aldrich
	Browse R&D Systems for Antibodies
	Search for antibodies at Abcam and the World's Antibody Gateway (free search engine of over 150 antibody companies)
	Browse Abnova for Monoclonal and Polyclonal Antibodies
	Search Novus for antibodies for YLPM1

Assays for YLPM1:

	Browse Invitrogen for biochemical assays
	Browse Kits and Assays available from Millipore
	Browse R&D Systems for biochemical assays
	Browse biochemical assays available from Enzo Life Sciences

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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Graphical View of Domain Structure for InterPro Entry P49750

ProtoNet protein and cluster: P49750

(According to MGI Jun 06 2009, UniProtKB, IUBMB,and/or Genatlas,
shRNA from OriGene, Sigma-Aldrich, RNAi from Sigma-Aldrich,
RNAi Products, Clones, and Q-PCR Products from Invitrogen, Millipore, OriGene, and/or Abnova, siRNAs from Applied Biosystems, SYBR primers from OriGene, Cell-based Assays from Millipore, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
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Inhib. RNA:		Invitrogen RNAi Products for gene knock-down (YLPM1)
		Browse for Gene Knock-down Tools from Millipore
		Browse Abnova for Chimera RNAi Products

Browse Origene for 29mer shRNA kit in GFP-retroviral vector

Applied Biosystems Silencer® siRNAs for YLPM1

Sigma-Aldrich siRNA for YLPM1

Browse shRNA at Sigma-Aldrich

Explore Sigma-Aldrich super-pooled esiRNAs

Clones:		Browse Clone Ranger at Invitrogen for clones
		Browse Clones for the Expression of Recombinant Proteins Available from Millipore

OriGene GFP tagged cDNA clone in CMV expression vector: NM_019589
Myc/DDK tagged cDNA clone in CMV expression vector: NM_019589
untagged cDNA clone in CMV expression vector: NM_019589

Primers:

Browse Quantitative PCR Central at Invitrogen for Q-PCR LUX™ Primers

OriGene genome-wide validated SYBR primer pairs: NM_019589

1 Gene Ontology (GO) molecular function term (links to tree view):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0003674	molecular_function	ND	--

About this table

(Pathways according to Invitrogen (maps by GeneGo), Millipore, Cell Signaling Technology, Sigma-Aldrich, KEGG and/or UniProtKB,
Sets of similar genes according to GeneDecks, Proteins Network according to SABiosciences, Interactions according to ¹UniProtKB, ²MINT, and/or ³STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
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1 Gene Ontology (GO) biological process term (links to tree view):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0008150	biological_process	ND	--

About this table

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, Sigma-Aldrich, Tocris Bioscience, and/or Novoseek and Drugs according to Enzo Life Sciences and/or PharmGKB)
About This Section

Browse drugs & compounds from Enzo Life Sciences

Browse Small Molecules at Sigma-Aldrich

Browse Tocris compounds for YLPM1

(GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 219 Homo sapiens; Jun 2 2009) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView,
non coding RNAs according to RNAdb,
ESTs according to GeneTide,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from Invitrogen, Millipore, and/or Abnova,
siRNAs from Applied Biosystems, Sigma-Aldrich,
shRNA from Sigma-Aldrich, OriGene,
Tagged/untagged cDNA clones from OriGene,
Expression Assays from Applied Biosystems)
About This Section

Inhib. RNA:		Invitrogen RNAi Products for gene knock-down (YLPM1)
		Browse for Gene Knock-down Tools from Millipore
		Browse Abnova for Chimera RNAi Products

Browse Origene for 29mer shRNA kit in GFP-retroviral vector

Sigma-Aldrich siRNA for YLPM1

Browse shRNA at Sigma-Aldrich

Explore Sigma-Aldrich super-pooled esiRNAs

Applied Biosystems Silencer® siRNAs:

NM_019589

REFSEQ mRNAs for YLPM1 gene:

NM_019589.2

Applied Biosystems TaqMan ® Gene Expression Assays:

NM_019589

              OriGene GFP tagged cDNA clone in CMV expression vector: NM_019589
                                 Myc/DDK tagged cDNA clone in CMV expression vector: NM_019589
                                 untagged cDNA clone in CMV expression vector: NM_019589

Additional cDNA sequence:

AK090435.1 AK095760.1 AK096592.1 AK297582.1 BC007792.1 BC023570.2 BC044636.1 BX647164.1

L40396.1 L40400.1 L40403.1

21 DOTS entries:

DT.86821316 DT.97837477 DT.100036129 DT.403807 DT.100796385 DT.95298666 DT.315813 DT.95250763

DT.40288195 DT.454492 DT.97822380 DT.315812 DT.91826700 DT.120777942 DT.448284 DT.95335030

DT.97770738 DT.315811 DT.97809341 DT.99929431 DT.120777936

24/337 AceView cDNA sequences (see all 337 ):

BM987348 BQ215629 AA975246 BQ005188 BM973535 AA808393 AA983226 AI687263

AA732626 AV713690 AI095196 AA610599 AA829415 BU733504 AU142662 BM982466

AI147227 AL601230 AW449505 BC007792 AA190600 BX090800 AA633087 CD722452

highest scoring ESTs for YLPM1:

L40396 AA181552 AA190600 AA191147 AA229821 AA402877 AA418612 AA463706 AA463969 AA514905

Unigene Cluster for YLPM1:

YLP motif containing 1

Hs.531111 [show with all ESTs]

Unigene Representative Sequence: NM_019589

GeneLoc Exon Structure

2 Ensembl transcripts including schematic representations:

ENST00000238571 ENST00000325680

(Experimental results according to ¹GeneNote and GNF BioGPS,
probe sets-to-genes annotations according to ²GeneAnnot , ³GeneTide , Sets of similar genes according to GeneDecks, Electronic Northern calculations according to data from UniGene (Build 219 Homo sapiens), SAGE tags according to CGAP, plus additional links to SOURCE, and/or GNF BioGPS, and/or EXPOLDB, and/or UniProtKB,
Expression Assays from Applied Biosystems )
About This Section

YLPM1 expression in normal and diseased human tissues

Applied Biosystems TaqMan ® Gene Expression Assays for YLPM1

¹ / ² / ³

10 probe-sets matching YLPM1 gene

Affymetrix probe-set	Array	# genes	Sensitivity	Specificity	Correlation	Length	Gb_Accession	Consensus	Uniqueness	Score	Rank
Affymetrix probe-set	Array	GeneAnnot data			GeneNote data		GeneTide data
33927_i_at²^{, 3}	U95-A	1	1.00	1.00	0.76	0.80	L40396	1.00	1.00	1.00	1
33926_at²^{, 3}	U95-A	1	1.00	1.00	0.84	1.23	L40403	0.80	1.00	0.91	1
33928_r_at²^{, 3}	U95-A	1	1.00	1.00	-0.02	0.44	L40396	1.00	1.00	1.00	1
36385_at²^{, 3}	U95-A	2	1.00	0.97	0.50	0.21	L40400	0.80	1.00	0.91	1
212787_at²^{, 3}	U133-A	1	1.00	1.00	--	--	AI952986	0.60	1.00	0.82	1
214659_x_at²	U133-A	1	1.00	1.00	--	--	--	--	--	--	--
214713_at²^{, 3}	U133-A	1	0.82	1.00	--	--	AI703162	0.40	1.00	0.76	1
212787_at²	U133Plus2	1	1.00	1.00	--	--	--	--	--	--	--
214659_x_at²	U133Plus2	1	1.00	1.00	--	--	--	--	--	--	--
214713_at²	U133Plus2	1	0.82	1.00	--	--	--	--	--	--	--

About this table

Data from

(Publications) and GNF BioGPS
About these images
About these images

CGAP SAGE TAG: --

SOURCE GeneReport for Unigene cluster: Hs.531111
Expression variation in blood from EXPOLDB for YLPM1

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD and/or ⁵MGI Jun 06 2009, with possible further links to Flybase and/or WormBase, Gene Trees according to Ensembl)
About This Section

Orthologs for YLPM1 gene from 5/8 species (see all 8 )

Organism	Gene	Locus	Description	Human Similarity	NCBI accessions
chimpanzee (Pan troglodytes)	YLPM1¹	--	YLP motif containing 1	99.72(n) 99.81(a)	453038 XM_510067.2 XP_510067.2
mouse (Mus musculus)	Ylpm1⁵	12	YLP motif containing 1	--	CA980613
zebrafish (Danio rerio)	57055341²	--	--	75.87(n)	57055341
African clawed frog (Xenopus laevis)	CA792944.1²	--	--	76.95(n)	CA792944.1
tropical clawed frog (Silurana tropicalis)	141995989²	--	--	78.66(n)	141995989

About this table Species with no ortholog for YLPM1

ENSEMBL Gene Tree for YLPM1

(Paralogs according to ¹HomoloGene
and ²Ensembl, Pseudogenes according to ³Pseudogene.org)
About This Section

(According to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, and UniProtKB, Linkage Disequilibrium by HapMap, Genotyping Reagents from Applied Biosystems)
About This Section

10/302 NCBI SNPs in YLPM1 are shown (see all 302 )
(Click for Applied Biosystems TaqMan ® Genotyping Assay) (see all 111)

AB	SNP ID	Valid	Chr 14 pos	Sequence	Recs	AA Chg	Type	More	Recs	Allele freq	Pop	Total sample	More
AB	Genomic Data				Transcription Data				Allele Frequencies
				--	--	--		--	--				--
	rs12889277^1,2	C,F,H	74299129(+)	`GATTTA/TTATGT`	1	--	ng5¹		7		EU EA WA NA	496
	rs7150879^1,2	H	74353660(+)	`TTTGGC/GTGAAA`	1	A/G	mis¹ ese³		4		EU EA WA	416
--	rs7159205^1,2	A	74372546(+)	`TGGCTG/TTTTCT`	1	--	ut3¹ ese³		0	--	--	--	--
--	rs7146395^1,2	C	74298400(+)	`cctggA/Ctactt`	1	--	ng5¹		0	--	--	--	--
--	rs17782755^1,2	F	74374068(+)	`TGCCAA/GTGAAA`	1	--	ng3¹		3		NA	142
	rs10135451^1,2	A	74298940(+)	`CCCCCA/CCACAC`	1	--	ng5¹ tfbs³		0	--	--	--	--
	rs2302835^1,2	A,C,F,H	74349214(+)	`CCACCG/AGGCCG`	1	P/P	syn¹ ese³		8		EA EU WA NA	2044
	rs2287401^1,2	C,F,H	74318422(+)	`CAAGGG/TATACC`	1	G/G	syn¹		12		NA EU EA WA	1044
	rs2302834^1,2	C,F,H	74349148(+)	`CAGCCA/TCCTCC`	1	P/P	syn¹		6		EA MN EU WA	2096
	rs12885527^1,2	F	74300590(+)	`TCGCAA/GTCCTA`	1	Q/Q	syn¹		2		NA	182

About this table

HapMap Linkage Disequilibrium images for YLPM1 (up to first 250kb)

(in which this Gene is Involved, According to OMIM, UniProtKB, PharmGKB, Genatlas, GeneTests, Blood group antigen gene mutations by BGMUT, HGMD, GAD, HuGE Navigator, BCGD, and/or TGDB.)
About This Section

(Possibly Related Articles in Doctor's Guide)
About This Section

(in PubMed. Associations of this gene to articles via ¹Novoseek, ²HGNC, ³Entrez Gene, ⁴UniProtKB/Swiss-Prot, ⁵UniProtKB/TrEMBL, ⁶GAD, and/or ⁷PharmGKB)
About This Section

10/13 PubMed articles for YLPM1 gene (see all 13 ):

Cloning of a gene bearing missense mutations in early-onset familial Alzheimer's disease. (PubMed id 7596406)^{2, 3, 4} Sherrington R....Holman K. (1995)
Global, in vivo, and site-specific phosphorylation dynamics in signaling networks. (PubMed id 17081983)^{3, 4} Olsen J.V....Mann M. (2006)
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)^{3, 4} Gerhard D.S....Malek J. (2004)
Large-scale characterization of HeLa cell nuclear phosphoproteins. (PubMed id 15302935)^{3, 4} Beausoleil S.A....Gygi S.P. (2004)
The DNA sequence and analysis of human chromosome 14. (PubMed id 12508121)^{3, 4} Heilig R.... Weissenbach J. (2003)
The nuclear PP1 interacting protein ZAP3 (ZAP) is a putative nucleoside kinase that complexes with SAM68, CIA, NF110/45, and HNRNP-G. (PubMed id 17890166)^{1, 3} Ulke-Lemee A....Moorhead G.B. (2007)
Combining protein-based IMAC, peptide-based IMAC, and MudPIT for efficient phosphoproteomic analysis. (PubMed id 18220336)⁴ Cantin G.T....Yates J.R. III (2008)
A quantitative atlas of mitotic phosphorylation. (PubMed id 18669648)⁴ Dephoure N.... Gygi S.P. (2008)
Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. (PubMed id 16344560)³ Kimura K.... Sugano S. (2006)
A human protein-protein interaction network: a resource for annotating the proteome. (PubMed id 16169070)³ Stelzl U....Wanker E.E. (2005)

(in PubMed, OMIM, and NCBI Bookshelf)
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		AND	OR
Aliases
Free Text

Query String		PubMed OMIM NCBI Bookshelf
	(Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, and/or H-InvDB)
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Entrez Gene: 56252	HGNC: 17798	AceView: YLPM1	Ensembl:ENSG00000119596	euGenes: HUgn56252
ECgene: YLPM1	H-InvDB: YLPM1

(According to HUGE)
About This Section

(According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section

Licensable Technologies for YLPM1
(Available from WIS Yeda, Salk, Tufts)

About This Section

(Reagents available from Applied Biosystems, Antibodies and assays by Cell Signaling Technology, Abcam, Novus Biologicals,
Sigma-Aldrich, R&D Systems, Millipore, Abnova, and/or Invitrogen, Clones available from OriGene,and/or Invitrogen, Drugs and/or compounds by Sigma-Aldrich,
Enzo Life Sciences, and/or Tocris Bioscience)
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Products for YLPM1:

TaqMan ® Gene Expression Assays

TaqMan ® Genotyping Assays

Free SNP selection tool

Invitrogen iPath Pathways	Invitrogen BLOCK-iT™ RNAi
Invitrogen Antibodies	Invitrogen Assays
Invitrogen Clones	Invitrogen Q-PCR Products
Invitrogen Human Recombinant Kinases	Invitrogen Custom Antibody and Peptide Service
Invitrogen Proteins / Assays / Screening Services	Search Invitrogen catalog for YLPM1-related products

	Millipore Custom Antibody & Bulk Services
	Millipore Preclinical / Clinical Development Services
	Millipore Immunoassay Services
	Millipore Target Screening & Profiling Services

	Predesigned and custom siRNAs for YLPM1		Browse antibodies at Sigma-Aldrich
	Explore super-pooled esiRNAs		Browse proteins at Sigma-Aldrich
	Browse shRNAs at Sigma-Aldrich		Browse small molecules at Sigma-Aldrich
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YLPM1 Gene

protein-coding GIFtS: 44

Aliases &
Descriptions
for YLPM1

Summaries
for YLPM1

Genomic Location
for YLPM1

Proteins
for YLPM1

Protein Domains/
Families
for YLPM1

Gene Function
for YLPM1

Pathways & Interactions
for YLPM1

Drugs & Compounds
for YLPM1

Transcripts
for YLPM1

Expression
for YLPM1

Orthologs
for YLPM1

Paralogs
for YLPM1

SNPs/Variants
for YLPM1

Disorders & Mutations
for YLPM1

Medical News
for YLPM1

Publications
for YLPM1

Search for YLPM1

Genome Databases showing YLPM1

Other Databases showing YLPM1

Specialized Databases showing YLPM1

Licensable Technologies
for YLPM1

Services
for YLPM1

Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

YLPM1 Gene

protein-coding GIFtS: 44

Aliases & Descriptionsfor YLPM1

Summariesfor YLPM1

Genomic Locationfor YLPM1

Proteinsfor YLPM1

Protein Domains/Familiesfor YLPM1

Gene Functionfor YLPM1

Pathways & Interactionsfor YLPM1

Drugs & Compoundsfor YLPM1

Transcriptsfor YLPM1

Expression for YLPM1

Orthologsfor YLPM1

Paralogsfor YLPM1

SNPs/Variantsfor YLPM1

Disorders & Mutationsfor YLPM1

Medical Newsfor YLPM1

Publicationsfor YLPM1

Search for YLPM1

Genome Databases showing YLPM1

Other Databases showing YLPM1

Specialized Databases showing YLPM1

Licensable Technologiesfor YLPM1

Servicesfor YLPM1

Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

Aliases &
Descriptions
for YLPM1

Summaries
for YLPM1

Genomic Location
for YLPM1

Proteins
for YLPM1

Protein Domains/
Families
for YLPM1

Gene Function
for YLPM1

Pathways & Interactions
for YLPM1

Drugs & Compounds
for YLPM1

Transcripts
for YLPM1

Expression
for YLPM1

Orthologs
for YLPM1

Paralogs
for YLPM1

SNPs/Variants
for YLPM1

Disorders & Mutations
for YLPM1

Medical News
for YLPM1

Publications
for YLPM1

Licensable Technologies
for YLPM1

Services
for YLPM1