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Aliases for YLPM1 Gene

Aliases for YLPM1 Gene

  • YLP Motif Containing 1 2 3 5
  • Nuclear Protein ZAP3 3 4
  • C14orf170 3 4
  • ZAP113 3 4
  • ZAP3 3 4
  • Protein Phosphatase 1, Regulatory Subunit 169 3
  • Chromosome 14 Open Reading Frame 170 2
  • Regulatory Subunit 169 2
  • Protein Phosphatase 1 2
  • PPP1R169 3

External Ids for YLPM1 Gene

Previous HGNC Symbols for YLPM1 Gene

  • C14orf170

Previous GeneCards Identifiers for YLPM1 Gene

  • GC14P074299
  • GC14P075230
  • GC14P055398

Summaries for YLPM1 Gene

GeneCards Summary for YLPM1 Gene

YLPM1 (YLP Motif Containing 1) is a Protein Coding gene. GO annotations related to this gene include poly(A) RNA binding and 6-phosphofructo-2-kinase activity.

UniProtKB/Swiss-Prot for YLPM1 Gene

  • Plays a role in the reduction of telomerase activity during differentiation of embryonic stem cells by binding to the core promoter of TERT and controlling its down-regulation.

Gene Wiki entry for YLPM1 Gene

No data available for Entrez Gene Summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for YLPM1 Gene

Genomics for YLPM1 Gene

Regulatory Elements for YLPM1 Gene

Enhancers for YLPM1 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around YLPM1 on UCSC Golden Path with GeneCards custom track

Promoters for YLPM1 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around YLPM1 on UCSC Golden Path with GeneCards custom track

Genomic Location for YLPM1 Gene

74,763,322 bp from pter
74,859,435 bp from pter
96,114 bases
Plus strand

Genomic View for YLPM1 Gene

Genes around YLPM1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
YLPM1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for YLPM1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for YLPM1 Gene

Proteins for YLPM1 Gene

  • Protein details for YLPM1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    YLP motif-containing protein 1
    Protein Accession:
    Secondary Accessions:
    • P49752
    • Q96I64
    • Q9P1V7

    Protein attributes for YLPM1 Gene

    1951 amino acids
    Molecular mass:
    219985 Da
    Quaternary structure:
    • Interacts with PPP1CA and NCOA5. Forms a complex with ILF2, ILF3, KHDRBS1, RBMX, NCOA5 and PPP1CA (By similarity).
    • Sequence=AAC42008.1; Type=Frameshift; Positions=1723; Evidence={ECO:0000305}; Sequence=AAF61275.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};

    Alternative splice isoforms for YLPM1 Gene


neXtProt entry for YLPM1 Gene

Proteomics data for YLPM1 Gene at MOPED

Post-translational modifications for YLPM1 Gene

  • Ubiquitination at Lys 490
  • Modification sites at PhosphoSitePlus

Other Protein References for YLPM1 Gene

No data available for DME Specific Peptides for YLPM1 Gene

Domains & Families for YLPM1 Gene

Gene Families for YLPM1 Gene

Protein Domains for YLPM1 Gene


Suggested Antigen Peptide Sequences for YLPM1 Gene

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with YLPM1: view

No data available for UniProtKB/Swiss-Prot for YLPM1 Gene

Function for YLPM1 Gene

Molecular function for YLPM1 Gene

UniProtKB/Swiss-Prot Function:
Plays a role in the reduction of telomerase activity during differentiation of embryonic stem cells by binding to the core promoter of TERT and controlling its down-regulation.

Phenotypes for YLPM1 Gene

GenomeRNAi human phenotypes for YLPM1:
genes like me logo Genes that share phenotypes with YLPM1: view

Animal Model Products

CRISPR Products

miRNA for YLPM1 Gene

miRTarBase miRNAs that target YLPM1

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for YLPM1 Gene

Localization for YLPM1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for YLPM1 Gene

Nucleus. Nucleus speckle. Note=Migrates to nucleolar caps upon blockage of transcription.

Gene Ontology (GO) - Cellular Components for YLPM1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005654 nucleoplasm IDA --
GO:0005737 cytoplasm IDA --
genes like me logo Genes that share ontologies with YLPM1: view

No data available for Subcellular locations from COMPARTMENTS for YLPM1 Gene

Pathways & Interactions for YLPM1 Gene

SuperPathways for YLPM1 Gene

No Data Available

Gene Ontology (GO) - Biological Process for YLPM1 Gene


No data available for Pathways by source and SIGNOR curated interactions for YLPM1 Gene

Drugs & Compounds for YLPM1 Gene

No Compound Related Data Available

Transcripts for YLPM1 Gene

Unigene Clusters for YLPM1 Gene

YLP motif containing 1:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for YLPM1 Gene

No ASD Table

Relevant External Links for YLPM1 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for YLPM1 Gene

mRNA expression in normal human tissues for YLPM1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for YLPM1 Gene

This gene is overexpressed in Nasal epithelium (11.9), Peripheral blood mononuclear cells (8.6), CD8 Tcells (7.7), and Lymph node (6.2).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for YLPM1 Gene

SOURCE GeneReport for Unigene cluster for YLPM1 Gene Hs.531111

mRNA Expression by UniProt/SwissProt for YLPM1 Gene

Tissue specificity: Expressed in neuronal, neuroblastoma and embryonic kidney cell lines (at protein level).
genes like me logo Genes that share expression patterns with YLPM1: view

Protein tissue co-expression partners for YLPM1 Gene

- Elite partner

Primer Products

No data available for mRNA differential expression in normal tissues for YLPM1 Gene

Orthologs for YLPM1 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for YLPM1 Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia YLPM1 35
  • 92.57 (n)
  • 94.69 (a)
YLPM1 36
  • 94 (a)
(Mus musculus)
Mammalia Ylpm1 35
  • 87.8 (n)
  • 88.3 (a)
Ylpm1 16
Ylpm1 36
  • 89 (a)
(Pan troglodytes)
Mammalia YLPM1 35
  • 99.72 (n)
  • 99.81 (a)
YLPM1 36
  • 100 (a)
(Rattus norvegicus)
Mammalia Ylpm1 35
  • 87.87 (n)
  • 88.71 (a)
(Canis familiaris)
Mammalia YLPM1 36
  • 95 (a)
(Monodelphis domestica)
Mammalia YLPM1 36
  • 74 (a)
(Ornithorhynchus anatinus)
Mammalia YLPM1 36
  • 71 (a)
(Gallus gallus)
Aves YLPM1 36
  • 61 (a)
(Anolis carolinensis)
Reptilia YLPM1 36
  • 46 (a)
(Danio rerio)
Actinopterygii ylpm1 36
  • 41 (a)
fruit fly
(Drosophila melanogaster)
Insecta ZAP3 36
  • 19 (a)
(Glycine max)
eudicotyledons Gma.6971 35
Species with no ortholog for YLPM1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for YLPM1 Gene

Gene Tree for YLPM1 (if available)
Gene Tree for YLPM1 (if available)

Paralogs for YLPM1 Gene

(1) SIMAP similar genes for YLPM1 Gene using alignment to 7 proteins:

genes like me logo Genes that share paralogs with YLPM1: view

No data available for Paralogs for YLPM1 Gene

Variants for YLPM1 Gene

Sequence variations from dbSNP and Humsavar for YLPM1 Gene

SNP ID Clin Chr 14 pos Sequence Context AA Info Type
rs7141001 -- 74,784,041(+) ACTGT(C/T)AGTGC intron-variant
rs7493800 -- 74,794,469(+) gagcc(A/C)ccgtg intron-variant
rs7493915 -- 74,772,197(+) TGAGT(A/G)AATTA intron-variant
rs7494188 -- 74,817,792(+) gctta(G/T)gcctg intron-variant
rs7142898 -- 74,787,607(+) CAGTA(A/T)GACAG intron-variant

Structural Variations from Database of Genomic Variants (DGV) for YLPM1 Gene

Variant ID Type Subtype PubMed ID
nsv832832 CNV Gain+Loss 17160897
esv1004666 CNV Loss 20482838
nsv826995 CNV Loss 20364138
nsv826996 CNV Loss 20364138
nsv1355 CNV Loss 18451855

Variation tolerance for YLPM1 Gene

Residual Variation Intolerance Score: 1.55% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 5.59; 72.41% of all genes are more intolerant (likely to be disease-causing)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Relevant External Links for YLPM1 Gene

Disorders for YLPM1 Gene

Relevant External Links for YLPM1

Atlas of Genetics and Cytogenetics in Oncology and Haematology:

No disorders were found for YLPM1 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for YLPM1 Gene

Publications for YLPM1 Gene

  1. Cloning of a gene bearing missense mutations in early-onset familial Alzheimer's disease. (PMID: 7596406) Sherrington R. … St George-Hyslop P.H. (Nature 1995) 2 3 4 67
  2. The nuclear PP1 interacting protein ZAP3 (ZAP) is a putative nucleoside kinase that complexes with SAM68, CIA, NF110/45, and HNRNP- G. (PMID: 17890166) Ulke-Lemee A. … Moorhead G.B.G. (Biochim. Biophys. Acta 2007) 3 23
  3. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 3
  4. Panorama of ancient metazoan macromolecular complexes. (PMID: 26344197) Wan C. … Emili A. (Nature 2015) 3
  5. A human interactome in three quantitative dimensions organized by stoichiometries and abundances. (PMID: 26496610) Hein M.Y. … Mann M. (Cell 2015) 3

Products for YLPM1 Gene

Sources for YLPM1 Gene