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Aliases for YLPM1 Gene

Aliases for YLPM1 Gene

  • YLP Motif Containing 1 2 3
  • Nuclear Protein ZAP3 3 4
  • C14orf170 3 4
  • ZAP113 3 4
  • ZAP3 3 4
  • Protein Phosphatase 1, Regulatory Subunit 169 3
  • Chromosome 14 Open Reading Frame 170 2
  • YLP Motif-Containing Protein 1 3
  • Regulatory Subunit 169 2
  • Protein Phosphatase 1 2
  • PPP1R169 3

External Ids for YLPM1 Gene

Previous HGNC Symbols for YLPM1 Gene

  • C14orf170

Previous GeneCards Identifiers for YLPM1 Gene

  • GC14P074299
  • GC14P075230
  • GC14P055398

Summaries for YLPM1 Gene

GeneCards Summary for YLPM1 Gene

YLPM1 (YLP Motif Containing 1) is a Protein Coding gene.

UniProtKB/Swiss-Prot for YLPM1 Gene

  • Plays a role in the reduction of telomerase activity during differentiation of embryonic stem cells by binding to the core promoter of TERT and controlling its down-regulation.

Gene Wiki entry for YLPM1 Gene

No data available for Entrez Gene Summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for YLPM1 Gene

Genomics for YLPM1 Gene

Regulatory Elements for YLPM1 Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for YLPM1 Gene

Start:
74,763,322 bp from pter
End:
74,859,435 bp from pter
Size:
96,114 bases
Orientation:
Plus strand

Genomic View for YLPM1 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for YLPM1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for YLPM1 Gene

Proteins for YLPM1 Gene

  • Protein details for YLPM1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P49750-YLPM1_HUMAN
    Recommended name:
    YLP motif-containing protein 1
    Protein Accession:
    P49750
    Secondary Accessions:
    • P49752
    • Q96I64
    • Q9P1V7

    Protein attributes for YLPM1 Gene

    Size:
    1951 amino acids
    Molecular mass:
    219985 Da
    Quaternary structure:
    • Interacts with PPP1CA and NCOA5. Forms a complex with ILF2, ILF3, KHDRBS1, RBMX, NCOA5 and PPP1CA (By similarity).
    SequenceCaution:
    • Sequence=AAC42008.1; Type=Frameshift; Positions=1723; Evidence={ECO:0000305}; Sequence=AAF61275.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};

    Alternative splice isoforms for YLPM1 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for YLPM1 Gene

Proteomics data for YLPM1 Gene at MOPED

Post-translational modifications for YLPM1 Gene

  • Ubiquitination at Lys490
  • Modification sites at PhosphoSitePlus

Other Protein References for YLPM1 Gene

No data available for DME Specific Peptides for YLPM1 Gene

Domains for YLPM1 Gene

Protein Domains for YLPM1 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for YLPM1 Gene

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with YLPM1: view

No data available for Gene Families and UniProtKB/Swiss-Prot for YLPM1 Gene

Function for YLPM1 Gene

Molecular function for YLPM1 Gene

UniProtKB/Swiss-Prot Function:
Plays a role in the reduction of telomerase activity during differentiation of embryonic stem cells by binding to the core promoter of TERT and controlling its down-regulation.

Gene Ontology (GO) - Molecular Function for YLPM1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001078 RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in negative regulation of transcription IEA --
GO:0003873 6-phosphofructo-2-kinase activity --
GO:0005515 protein binding IPI 21078624
GO:0005524 ATP binding --
GO:0044822 poly(A) RNA binding IDA 22681889
genes like me logo Genes that share ontologies with YLPM1: view

Animal Model Products

CRISPR Products

miRNA for YLPM1 Gene

miRTarBase miRNAs that target YLPM1

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for YLPM1

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Phenotypes , Animal Models , Transcription Factor Targeting and HOMER Transcription for YLPM1 Gene

Localization for YLPM1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for YLPM1 Gene

Nucleus. Nucleus speckle. Note=Migrates to nucleolar caps upon blockage of transcription.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for YLPM1 Gene COMPARTMENTS Subcellular localization image for YLPM1 gene
Compartment Confidence
nucleus 5
cytosol 3

Gene Ontology (GO) - Cellular Components for YLPM1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IDA 17890166
GO:0005654 nucleoplasm IDA --
GO:0005737 cytoplasm IDA --
GO:0016607 nuclear speck IEA --
genes like me logo Genes that share ontologies with YLPM1: view

Pathways for YLPM1 Gene

SuperPathways for YLPM1 Gene

No Data Available

Gene Ontology (GO) - Biological Process for YLPM1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000122 negative regulation of transcription from RNA polymerase II promoter IEA --
GO:0006000 fructose metabolic process --
GO:0006351 transcription, DNA-templated IEA --
GO:0008150 biological_process ND --
GO:0032204 regulation of telomere maintenance IEA --
genes like me logo Genes that share ontologies with YLPM1: view

No data available for Pathways by source for YLPM1 Gene

Transcripts for YLPM1 Gene

Unigene Clusters for YLPM1 Gene

YLP motif containing 1:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for YLPM1

Primer Products

  • QuantiTect SYBR Green Assays in human,mouse,rat
  • Pre-validated RT² qPCR Primer Assay in human,mouse,rat
  • QuantiFast Probe-based Assays in human,mouse,rat

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for YLPM1 Gene

No ASD Table

Relevant External Links for YLPM1 Gene

GeneLoc Exon Structure for
YLPM1
ECgene alternative splicing isoforms for
YLPM1

Expression for YLPM1 Gene

mRNA expression in normal human tissues for YLPM1 Gene

Protein differential expression in normal tissues for YLPM1 Gene

This gene is overexpressed in Nasal epithelium (11.9), Peripheral blood mononuclear cells (8.6), CD8 Tcells (7.7), and Lymph node (6.2).

Integrated Proteomics: protein expression from ProteomicsDB, MOPED, and MaxQB for YLPM1 Gene

SOURCE GeneReport for Unigene cluster for YLPM1 Gene Hs.531111

mRNA Expression by UniProt/SwissProt for YLPM1 Gene

P49750-YLPM1_HUMAN
Tissue specificity: Expressed in neuronal, neuroblastoma and embryonic kidney cell lines (at protein level).
genes like me logo Genes that share expressions with YLPM1: view

Expression partners for YLPM1 Gene

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and mRNA differential expression in normal tissues for YLPM1 Gene

Orthologs for YLPM1 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for YLPM1 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia YLPM1 35
  • 92.57 (n)
  • 94.69 (a)
YLPM1 36
  • 94 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Ylpm1 35
  • 87.8 (n)
  • 88.3 (a)
Ylpm1 16
Ylpm1 36
  • 89 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia YLPM1 35
  • 99.72 (n)
  • 99.81 (a)
YLPM1 36
  • 100 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Ylpm1 35
  • 87.87 (n)
  • 88.71 (a)
dog
(Canis familiaris)
Mammalia YLPM1 36
  • 95 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia YLPM1 36
  • 74 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia YLPM1 36
  • 71 (a)
OneToOne
chicken
(Gallus gallus)
Aves YLPM1 36
  • 61 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia YLPM1 36
  • 46 (a)
OneToOne
zebrafish
(Danio rerio)
Actinopterygii ylpm1 36
  • 41 (a)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta ZAP3 36
  • 19 (a)
OneToOne
soybean
(Glycine max)
eudicotyledons Gma.6971 35
Species with no ortholog for YLPM1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for YLPM1 Gene

ENSEMBL:
Gene Tree for YLPM1 (if available)
TreeFam:
Gene Tree for YLPM1 (if available)

Paralogs for YLPM1 Gene

Selected SIMAP similar genes for YLPM1 Gene using alignment to 7 proteins:

genes like me logo Genes that share paralogs with YLPM1: view

No data available for Paralogs for YLPM1 Gene

Variants for YLPM1 Gene

Sequence variations from dbSNP and Humsavar for YLPM1 Gene

SNP ID Clin Chr 14 pos Sequence Context AA Info Type MAF
rs878206 -- 74,797,072(-) ATCAC(C/T)TGAAC intron-variant
rs888413 -- 74,800,693(+) AGATA(C/T)GGCAG intron-variant
rs957345 -- 74,809,376(-) GGCTA(C/G)AGAAC intron-variant
rs973879 -- 74,831,024(+) TCTCT(C/T)TACAC intron-variant
rs1046377 -- 74,836,029(+) CAACA(A/G)AGAGT utr-variant-3-prime, nc-transcript-variant

Structural Variations from Database of Genomic Variants (DGV) for YLPM1 Gene

Variant ID Type Subtype PubMed ID
nsv832832 CNV Gain+Loss 17160897
esv1004666 CNV Loss 20482838
nsv826995 CNV Loss 20364138
nsv826996 CNV Loss 20364138
nsv1355 CNV Loss 18451855

Relevant External Links for YLPM1 Gene

HapMap Linkage Disequilibrium report
YLPM1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for YLPM1 Gene

Disorders for YLPM1 Gene

No disorders were found for YLPM1 Gene.

No data available for MalaCards , OMIM , UniProtKB/Swiss-Prot , University of Copenhagen DISEASES , Novoseek inferred disease relationships , Genatlas and External Links for YLPM1 Gene

Publications for YLPM1 Gene

  1. The nuclear PP1 interacting protein ZAP3 (ZAP) is a putative nucleoside kinase that complexes with SAM68, CIA, NF110/45, and HNRNP- G. (PMID: 17890166) Ulke-Lemee A. … Moorhead G.B.G. (Biochim. Biophys. Acta 2007) 3 4 23
  2. Cloning of a gene bearing missense mutations in early-onset familial Alzheimer's disease. (PMID: 7596406) Sherrington R. … St George-Hyslop P.H. (Nature 1995) 2 3 4
  3. The DNA sequence and analysis of human chromosome 14. (PMID: 12508121) Heilig R. … Weissenbach J. (Nature 2003) 3 4
  4. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4
  5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4

Products for YLPM1 Gene

Sources for YLPM1 Gene

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