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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

YLPM1 Gene

protein-coding   GIFtS: 45
GCID: GC14P075230

YLP motif containing 1

(Previous name: chromosome 14 open reading frame 170 )
(Previous symbol: C14orf170)
 Explore 7 diseases affiliated with
YLPM1 via our new
 Human Malady Compendium 
Biological research products
for YLPM1
    

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, and/or 10fRNAdb)
About This Section

Aliases
YLP Motif Containing 11 2     ZAP32 3
C14orf1701 2 3     ZAP1
Nuclear Protein ZAP32 3     Chromosome 14 Open Reading Frame 1701
ZAP1132 3     YLP Motif-Containing Protein 12

External Ids:    HGNC: 177981   Entrez Gene: 562522   Ensembl: ENSG000001195967   UniProtKB: P497503   

Export aliases for YLPM1 gene to outside databases

Previous GC identifers: GC14P074299 GC14P055398


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

UniProtKB/Swiss-Prot: YLPM1_HUMAN, P49750
Function: Plays a role in the reduction of telomerase activity during differentiation of embryonic stem cells by
binding to the core promoter of TERT and controlling its down-regulation (By similarity)

Gene Wiki entry for YLPM1


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000014.8  NC_018925.1  NT_026437.12  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the YLPM1 gene promoter:
         Pax-5   CUTL1   Tal-1beta   E47   E2F   E2F-1   HOXA5   AP-2beta   AP-2alpha   AP-2alphaA   
         Other transcription factors

Browse SwitchGear Promoter luciferase reporter plasmids
   Search SABiosciences Chromatin IP Primers for YLPM1

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat YLPM1


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 14q24.3   Ensembl cytogenetic band:  14q24.3   HGNC cytogenetic band: 14q24.3

YLPM1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
YLPM1 gene location

GeneLoc information about chromosome 14         GeneLoc Exon Structure

GeneLoc location for GC14P075230:  view genomic region     (about GC identifiers)

Start:
75,230,069 bp from pter      End:
75,304,013 bp from pter
Size:
73,945 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section

UniProtKB/Swiss-Prot: YLPM1_HUMAN, P49750 (See protein sequence)
Recommended Name: YLP motif-containing protein 1  
Size: 1951 amino acids; 219985 Da
Subunit: Interacts with PPP1CA and NCOA5. Forms a complex with ILF2, ILF3, KHDRBS1, RBMX, NCOA5 and PPP1CA (By
similarity)
Subcellular location: Nucleus. Nucleus speckle (By similarity). Note=Migrates to nucleolar caps upon blockage of
transcription
Sequence caution: Sequence=AAC42008.1; Type=Frameshift; Positions=1723; Sequence=AAF61275.1; Type=Erroneous gene model
prediction;
Secondary accessions: P49752 Q96I64 Q9P1V7
Alternative splicing: 3 isoforms:  P49750-1   P49750-3   P49750-4   (Ref.2 (AK095760) sequence is in conflict in position: 524:S->P)

Explore the universe of human proteins at neXtProt for YLPM1: NX_P49750

Post-translational modifications:

  • View modification sites using PhosphoSitePlus2
  • View neXtProt modification sites for NX_P49750

  • YLPM1 Protein expression data from MOPED and PaxDb:    About this image 
    Estimated protein expression log10 (pmol).

    REFSEQ proteins: NP_062535.2  
    ENSEMBL proteins: 
     ENSP00000447921   ENSP00000324463   ENSP00000449860   ENSP00000448367   ENSP00000238571  

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    Uscn Proteins for YLPM1

    Gene Ontology (GO): 2 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus IDA17890166
    GO:0016607nuclear speck IEA--


    YLPM1 for ontologies           About GeneDecksing



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    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section

    YLPM1 for domains           About GeneDecksing

    1 InterPro domain/family:
     IPR026314 YLP_motif_con_p1

    Graphical View of Domain Structure for InterPro Entry P49750

    ProtoNet protein and cluster: P49750


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
    About This Section

    Function Summary:

         UniProtKB/Swiss-Prot: YLPM1_HUMAN, P49750
    Function: Plays a role in the reduction of telomerase activity during differentiation of embryonic stem cells by
    binding to the core promoter of TERT and controlling its down-regulation (By similarity)

    miRNA
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    hsa-miR-3651 hsa-miR-875-5p hsa-miR-146a hsa-miR-765 hsa-let-7a-2* hsa-miR-3916 hsa-miR-298 hsa-miR-3908
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    Gene Ontology (GO): 3 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0001078RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in negative regulation of transcription IEA--
    GO:0003674molecular_function ND--
    GO:0005515protein binding IPI--


    YLPM1 for ontologies           About GeneDecksing



    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
    About This Section



    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for YLPM1

    STRING Interaction Network Preview (showing 5 interactants - click image to see 18)

    5/553 Interacting proteins for YLPM1 (P497501, 2, 3 ENSP000003244634) via UniProtKB, MINT, STRING, and/or I2D (see all 553)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    PPP1CAP621362, 3, ENSP000003260314MINT-7947479 I2D: score=1 STRING: ENSP00000326031
    CACNA1AO005551, 3EBI-712871,EBI-766279 I2D: score=1 
    BMP1P134973, ENSP000003057144I2D: score=3 STRING: ENSP00000305714
    APBB1O002133, ENSP000002994024I2D: score=2 STRING: ENSP00000299402
    MLH1P406923, ENSP000002317904I2D: score=1 STRING: ENSP00000231790
    About this table

    Gene Ontology (GO): 4 biological process terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006351transcription, DNA-dependent ----
    GO:0006355regulation of transcription, DNA-dependent ----
    GO:0008150biological_process ND--
    GO:0032204regulation of telomere maintenance IEA--


    YLPM1 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for YLPM1
    Search CenterWatch for drugs/clinical trials and news about YLPM1 

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for YLPM1 gene: 
    NM_019589.2  

    Unigene Cluster for YLPM1:

    YLP motif containing 1
    Hs.531111  [show with all ESTs]
    Unigene Representative Sequence: NM_019589
    8 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000552421 ENST00000325680(uc001xqj.4 uc001xql.4) ENST00000549293
    ENST00000547879(uc001xqm.1) ENST00000546901 ENST00000550021 ENST00000549197
    ENST00000238571

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    8/37 QIAGEN miScript miRNA Assays for microRNAs that regulate YLPM1 (see all 37):
    hsa-miR-3651 hsa-miR-875-5p hsa-miR-146a hsa-miR-765 hsa-let-7a-2* hsa-miR-3916 hsa-miR-298 hsa-miR-3908
    Browse SwitchGear 3'UTR luciferase reporter plasmids
    Inhib. RNA
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    Browse for Gene Knock-down Tools from EMD Millipore
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    OriGene siRNA: YLPM1
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    Additional cDNA sequence: 

    AK090435.1 AK095760.1 AK096592.1 AK297582.1 BC007792.1 BC023570.2 BC044636.1 BX647164.1 
    L40396.1 L40400.1 L40403.1 

    21 DOTS entries:

    DT.86821316  DT.97837477  DT.100036129  DT.403807  DT.100796385  DT.95298666  DT.315813  DT.95250763 
    DT.40288195  DT.454492  DT.97822380  DT.315812  DT.120777942  DT.448284  DT.95335030  DT.315811 
    DT.91826700  DT.97770738  DT.120777936  DT.97809341  DT.99929431 

    24/337 AceView cDNA sequences (see all 337):

    AA983226 AA808393 BQ005188 BE705887 BU676463 AL601230 BG057803 BM699252 
    AI917029 AL710386 BQ215629 AI952986 BC007792 AI687263 AW592344 AA975246 
    BX090800 AI352606 AA235717 CD722452 AI572305 BQ008617 AI147227 BE048052 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    YLPM1 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS
    CGAP TAG: --

    Microarray
    RNAseq (Illumina Body Map)
    (100×FPKM)½
    SAGE (Serial Analysis of Gene Expression)

    About this image
    See YLPM1 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for YLPM1

    SOURCE GeneReport for Unigene cluster: Hs.531111

    UniProtKB/Swiss-Prot: YLPM1_HUMAN, P49750
    Tissue specificity: Expressed in neuronal, neuroblastoma and embryonic kidney cell lines (at protein level)

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    In Situ
    Assay Products:
     

     
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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of eukaryotes.

    Orthologs for YLPM1 gene from 8/22 species (see all 22)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Ylpm11 , 5 YLP motif containing 11, 5 89.39(n)1
    90.09(a)1
      12 (39.50 cM)5
    565311  NM_178363.31  NP_848140.31 
     849963215 
    chicken
    (Gallus gallus)
    Aves YLPM11 YLP motif containing 1 80.56(n)
    86.92(a)
      423356  XM_421271.3  XP_421271.3 
    lizard
    (Anolis carolinensis)
    Reptilia YLPM16
    --
    50(a)
    1 ↔ 1
    1(22796816-22857691)
    African clawed frog
    (Xenopus laevis)
    Amphibia CA792944.12   -- 76.95(n)    CA792944.1 
    zebrafish
    (Danio rerio)
    Actinopterygii 570553412   -- 75.87(n)    57055341 
    fruit fly
    (Drosophila melanogaster)
    Insecta ZAP36
    --
    17(a)
    1 ↔ 1
    X(9966179-9976523)
    thale cress
    (Arabidopsis thaliana)
    eudicotyledons AT5G627606
    ZAP-like protein
    23(a)
    1 ↔ 1
    5(25204472-25209571)
    rice
    (Oryza sativa)
    Liliopsida --
    nuclear protein ZAP-related, putative, expressed
    24(a)
    1 ↔ 1
    2(6433220-6441715)


    ENSEMBL Gene Tree for YLPM1 (if available)
    TreeFam Gene Tree for YLPM1 (if available) 

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
      --

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/1123 NCBI SNPs in YLPM1 are shown (see all 1123    About this table
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 14 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs769625271,2
    C,--75228209(+) AAAATC/TTACTA 1 -- us2k10--------
    rs1165482501,2
    F,--75228212(+) ATTTAC/TTATGC 1 -- us2k11Minor allele frequency- T:0.03WA 118
    rs763785211,2
    C,--75228231(+) TAAGAC/TATGTG 1 -- us2k12Minor allele frequency- T:0.09NA 122
    rs1448428361,2
    --75228303(+) ATTGAG/TGTTGC 1 -- us2k10--------
    rs1819005251,2
    --75228418(+) GTCCTC/GTCTGC 1 -- us2k10--------
    rs1173148691,2
    C,F,--75228450(+) ACTTTG/CAAACA 1 -- us2k11Minor allele frequency- C:0.04NA 120
    rs342532391,2
    C,--75228487(+) CTCTC-/TTTTTT 1 -- us2k11Minor allele frequency- T:0.00NA 2
    rs284616011,2
    C,--75228488(+) TCTCTC/TTTTTT 1 -- us2k1 trp31Minor allele frequency- T:0.00WA 2
    rs71463951,2
    C,F,--75228647(+) CCTGGC/ATACTT 1 -- us2k18Minor allele frequency- A:0.20NA WA CSA 15
    rs1916670951,2
    --75228717(+) GACCTA/GGTGAT 1 -- us2k10--------

    HapMap Linkage Disequilibrium report for YLPM1 (75230069 - 75304013 bp)
    Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
    Database of Genomic Variants (DGV): 1 variation for YLPM1
         1 CNV: 4839

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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section

    YLPM1 for disorders           About GeneDecksing

    7 diseases for YLPM1:    About MalaCards
    early-onset familial alzheimer disease    macular degeneration    alzheimer's disease    myeloma
    ataxia    neuroblastoma    neuronitis


    Export disorders for YLPM1 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for YLPM1 gene, integrated from 9 sources (see all 34):
    (articles sorted by number of sources associating them with YLPM1)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Cloning of a gene bearing missense mutations in early-onset familial Alzheimer's disease. (PubMed id 7596406)1, 2, 3 Sherrington R....Holman K. (1995)
    2. The nuclear PP1 interacting protein ZAP3 (ZAP) is a putative nucleoside kinase that complexes with SAM68, CIA, NF110/45, and HNRNP- G. (PubMed id 17890166)1, 2, 9 Ulke-Lemee A.... Moorhead G.B.G. (2007)
    3. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
    4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    5. The DNA sequence and analysis of human chromosome 14. (PubMed id 12508121)1, 2 Heilig R.... Weissenbach J. (2003)
    6. A census of human soluble protein complexes. (PubMed id 22939629)1 Havugimana P.C....Emili A. (2012)
    7. Protein phosphatase 1a interacting proteins in the hum an brain. (PubMed id 22321011)1 Esteves S.L....da Cruz e Silva E.F. (2012)
    8. Intersectin (ITSN) family of scaffolds function as mol ecular hubs in protein interaction networks. (PubMed id 22558309)1 Wong K.A....O'Bryan J.P. (2012)
    9. Functional proteomics establishes the interaction of S IRT7 with chromatin remodeling complexes and expands its role in regulation of R NA polymerase I transcription. (PubMed id 22586326)1 Tsai Y.C....Cristea I.M. (2012)
    10. Initial characterization of the human central proteome. (PubMed id 21269460)2 Burkard T.R.... Colinge J. (2011)

    (in PubMed, OMIM, and NCBI Bookshelf)
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    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 56252 HGNC: 17798 AceView: YLPM1 Ensembl:ENSG00000119596 euGenes: HUgn56252
    ECgene: YLPM1 H-InvDB: YLPM1

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for YLPM1 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for YLPM1 gene:
    Search GeneIP for patents involving YLPM1

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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