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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

YKT6 Gene

protein-coding   GIFtS: 57
GCID: GC07P044207

YKT6 v-SNARE homolog (S. cerevisiae)
 Explore 3 diseases affiliated with
YKT6 via
MalaCards
our new
 Human Malady Compendium 
Biological research products
for YKT6    

Aliases
for YKT6 gene

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, and/or 10fRNAdb)
About This Section
Aliases
YKT6 V-SNARE Homolog (S. Cerevisiae)1 2     YKT6 V-SNARE Protein2
R-SNARE2     YKT6, S. Cerevisiae, Homolog Of2
SNARE Protein Ykt62     EC 2.3.1.-3
Synaptobrevin Homolog YKT62     EC 2.3.18

External Ids:    HGNC: 169591   Entrez Gene: 106522   Ensembl: ENSG000001066367   OMIM: 6062095   UniProtKB: O154983   

Export aliases for YKT6 gene to outside databases

Previous GC identifers: GC07P043887 GC07P043981 GC07P044013


Summaries
for YKT6 gene

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section
Entrez Gene summary for YKT6:
This gene product is one of the SNARE recognition molecules implicated in vesicular transport between secretory
compartments. It is a membrane associated, isoprenylated protein that functions at the endoplasmic reticulum-Golgi
transport step. This protein is highly conserved from yeast to human and can functionally complement the loss of the
yeast homolog in the yeast secretory pathway. (provided by RefSeq, Jul 2008)

UniProtKB/Swiss-Prot: YKT6_HUMAN, O15498
Function: Vesicular soluble NSF attachment protein receptor (v-SNARE) mediating vesicle docking and fusion to a
specific acceptor cellular compartment. Functions in endoplasmic reticulum to Golgi transport; as part of a SNARE
complex composed of GOSR1, GOSR2 and STX5. Functions in early/recycling endosome to TGN transport; as part of a SNARE
complex composed of BET1L, GOSR1 and STX5. Has a S-palmitoyl transferase activity

Gene Wiki entry for YKT6


Genomic Views
for YKT6 gene

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000007.13  NC_018918.1  NT_007819.17  NT_079592.2  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the YKT6 gene promoter:
         c-Fos   AP-1   ATF-2   SREBP-1c   c-Jun   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 3): YKT6 promoter sequence
   Search SABiosciences Chromatin IP Primers for YKT6

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat YKT6


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 7p15.1   Ensembl cytogenetic band:  7p13   HGNC cytogenetic band: 7p13

YKT6 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
YKT6 gene location

GeneLoc information about chromosome 7         GeneLoc Exon Structure

GeneLoc location for GC07P044207:  view genomic region     (about GC identifiers)

Start:
 44,240,567 bp from pter      End:
 44,253,893 bp from pter
Size:
 13,327 bases      Orientation:
 plus strand

1 alternative location:
Chr7+,CRA_TCAG 44,280,084-44,293,399     

Proteins
for YKT6 gene

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section
UniProtKB/Swiss-Prot: YKT6_HUMAN, O15498 (See protein sequence)
Recommended Name: Synaptobrevin homolog YKT6 precursor  
Size: 198 amino acids; 22418 Da
Subunit: Identified in 2 different SNARE complexes; the first one composed of GOSR1, GOSR2 and STX5 and the second one
composed of BET1L, GOSR1 and STX5 (By similarity)
Subcellular location: Cytoplasm, cytosol. Cytoplasmic vesicle membrane; Lipid-anchor; Cytoplasmic side. Golgi apparatus
membrane; Lipid-anchor; Cytoplasmic side. Note=Probably cycles through vesicles between Golgi and endosomes
Secondary accessions: Q53F01 Q6FGU9 Q6IB15

Explore the universe of human proteins at neXtProt for YKT6: NX_O15498

Post-translational modifications:

  • Palmitoylated; catalyzes its own palmitoylation. Palmitoylation is required for Golgi targeting1
  • Farnesylation is required for Golgi targeting1
  • View modification sites using PhosphoSitePlus2
  • View neXtProt modification sites for NX_O15498

    • 4/8 DME Specific Peptides for YKT6 (O15498) (see all 8)
     ELDETKI  RASVKEQ  QSKAFYK  FTLLEKVL 

    YKT6 Protein expression data from MOPED and PaxDb:    About this image 
    YKT6 Protein Expression
    REFSEQ proteins: NP_006546.1  
    ENSEMBL proteins: 
     ENSP00000420805   ENSP00000223369   ENSP00000412414  

    Human Recombinant Protein Products for YKT6: 
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    Browse ProSpec Recombinant Proteins
    Uscn Proteins for YKT6

    Gene Ontology (GO): 5/11 cellular component terms (GO ID links to tree view) (see all 11):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000139Golgi membrane IEA--
    GO:0005737cytoplasm IDA--
    GO:0005739mitochondrion IDA--
    GO:0005768endosome IDA15215310
    GO:0005783endoplasmic reticulum IDA9211930

    YKT6 for ontologies           About GeneDecksing



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    Protein Domains /
    Families
    for YKT6 gene

    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    YKT6 for domains           About GeneDecksing

    3 InterPro domains/families:
     IPR010908 Longin_dom
     IPR001388 Synaptobrevin
     IPR011012 Longin-like_dom

    Graphical View of Domain Structure for InterPro Entry O15498

    ProtoNet protein and cluster: O15498

    1 Blocks protein family: IPB001388 Synaptobrevin

    UniProtKB/Swiss-Prot: YKT6_HUMAN, O15498
    Domain: The longin domain regulates palmitoylation and membrane targeting
    Similarity: Belongs to the synaptobrevin family
    Similarity: Contains 1 longin domain
    Similarity: Contains 1 v-SNARE coiled-coil homology domain


    Function
    for YKT6 gene

    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, Sirion Biotech, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, Sirion Biotech, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
    About This Section
    Molecular Function:

         UniProtKB/Swiss-Prot Summary: YKT6_HUMAN, O15498
    Function: Vesicular soluble NSF attachment protein receptor (v-SNARE) mediating vesicle docking and fusion to a
    specific acceptor cellular compartment. Functions in endoplasmic reticulum to Golgi transport; as part of a SNARE
    complex composed of GOSR1, GOSR2 and STX5. Functions in early/recycling endosome to TGN transport; as part of a SNARE
    complex composed of BET1L, GOSR1 and STX5. Has a S-palmitoyl transferase activity

         Enzyme Numbers (IUBMB): EC 2.3.12 EC 2.3.1.-1

         Gene Ontology (GO): 2 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005484SNAP receptor activity IDA15215310
    GO:0019706protein-cysteine S-palmitoleyltransferase activity IDA15479160
         
    YKT6 for ontologies           About GeneDecksing


    Phenotypes:
         1 GenomeRNAi human phenotype for YKT6:
     Increased gamma-H2AX phosphory 

    Animal Models:
       inGenious Targeting Laboratory - Customizable classic, inducible, and humanized mouse model solutions for YKT6 

    miRNA
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    hsa-miR-549 hsa-miR-579 hsa-miR-218-2* hsa-miR-3918 hsa-miR-1257 hsa-miR-129-3p hsa-miR-1207-5p hsa-miR-129*
    SwitchGear 3'UTR luciferase reporter plasmid: YKT6 3' UTR sequence
    Inhib. RNA
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    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for YKT6 (see all 7)
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    Gene Editing
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    Clone
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    In Situ Assay
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    Pathways & Interactions
    for YKT6 gene

    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
    About This Section

    Unified GeneCards pathways  About this table 
    See pathways by source

    Super-pathwaycontained gene-specific pathways
    1Nicotine Pathway (Dopaminergic Neuron), Pharmacodynamics
    		Nicotine Pathway (Dopaminergic Neuron), Pharmacodynamics1.00
    		SNARE interactions in vesicular transport0.40
    2Clathrin-dependent protein traffic
    		Transport_Clathrin-coated vesicle cycle0.66

    Pathway sources
    See GeneCards unified pathways
    Show all pathways


    1 GeneGo (Thomson Reuters) Pathway for YKT6
        Transport Clathrin-coated vesicle cycle

    1 PharmGKB Pathway for YKT6
        Nicotine Pathway (Dopaminergic Neuron), Pharmacodynamics

    1         Kegg Pathway  (Kegg details for YKT6):
        SNARE interactions in vesicular transport


    YKT6 for pathways           About GeneDecksing

    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for YKT6

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    5/71 Interacting proteins for YKT6 (O154983 ENSP000002233694) via UniProtKB, MINT, STRING, and/or I2D (see all 71)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    USO1O607633, ENSP000004116984I2D: score=4 STRING: ENSP00000411698
    CTPS1P178123, ENSP000003616994I2D: score=3 STRING: ENSP00000361699
    BET1LQ9NYM93, ENSP000003722104I2D: score=2 STRING: ENSP00000372210
    COG3Q96JB23, ENSP000002586544I2D: score=2 STRING: ENSP00000258654
    NAPBQ9H1153, ENSP000003662254I2D: score=2 STRING: ENSP00000366225
    About this table

    Gene Ontology (GO): 5/6 biological process terms (GO ID links to tree view) (see all 6):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006810transport ----
    GO:0006888ER to Golgi vesicle-mediated transport IDA9211930
    GO:0006903vesicle targeting IDA9211930
    GO:0006904vesicle docking involved in exocytosis IDA9211930
    GO:0015031protein transport IEA--

    YKT6 for ontologies           About GeneDecksing



    Drugs & Compounds
    for YKT6 gene

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section

    YKT6 for compounds           About GeneDecksing

    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for YKT6
    1 Novoseek chemical compound relationship for YKT6 gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    cysteine 34.2 2 15044687 (1), 15479160 (1)

    Search CenterWatch for drugs/clinical trials and news about YKT6 

    Transcripts
    for YKT6 gene

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, Sirion Biotech, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section
    REFSEQ mRNAs for YKT6 gene: 
    NM_006555.3  

    Unigene Cluster for YKT6:

    YKT6 v-SNARE homolog (S. cerevisiae)
    Hs.520794  [show with all ESTs]
    Unigene Representative Sequence: NM_006555
    7 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000496112 ENST00000447123 ENST00000223369(uc003tkm.3 uc011kbv.2)
    ENST00000463014 ENST00000478411 ENST00000424864 ENST00000421621

    miRNA
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    hsa-miR-549 hsa-miR-579 hsa-miR-218-2* hsa-miR-3918 hsa-miR-1257 hsa-miR-129-3p hsa-miR-1207-5p hsa-miR-129*
    SwitchGear 3'UTR luciferase reporter plasmid: YKT6 3' UTR sequence
    Inhib. RNA
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    Clone
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    Additional cDNA sequence: 

    AB451317.1 AB451447.1 AF091079.1 AK075018.1 AK223488.1 AK299158.1 AK312622.1 BC007319.2 
    BT007078.1 CR456989.1 CR542008.1 U95735.1 

    21 DOTS entries:

    DT.100825169  DT.317823  DT.101956730  DT.100825168  DT.95239327  DT.92456279  DT.95265602  DT.121097123 
    DT.100008256  DT.100044674  DT.121096981  DT.95265587  DT.100044673  DT.121096976  DT.92456277  DT.95265597 
    DT.95265603  DT.95348990  DT.121096974  DT.95265590  DT.95265601 

    24/567 AceView cDNA sequences (see all 567):

    CD675502 CF126052 BG333800 BQ879059 BU553381 BE265205 CA309982 BQ100787 
    BM810401 BM680985 BM751620 BM795896 T31130 BE896887 BX097518 BQ949804 
    AW027293 BF194876 BQ671458 BM982994 CA439756 BE792456 BU168280 BM719475 

    GeneLoc Exon Structure

    5/6 Alternative Splicing Database (ASD) splice patterns (SP) for YKT6 (see all 6)    About this scheme

    ExUns: 1a · 1b ^ 2a · 2b ^ 3 ^ 4a · 4b ^ 5a · 5b ^ 6a · 6b ^ 7 ^ 8a · 8b · 8c · 8d
    SP1:                                -                 -     -           -                           
    SP2:                                -                 -     -     -     -                           
    SP3:                                                  -     -                                       
    SP4:              -                 -                                                               
    SP5:                                                                    -                           


    ECgene alternative splicing isoforms for YKT6

    Expression
    for YKT6 gene

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    YKT6 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS
    CGAP TAG: TCATTTTCCT
    YKT6 Expression
    About this image
    See YKT6 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for YKT6

    SOURCE GeneReport for Unigene cluster: Hs.520794
        SABiosciences Custom PCR Arrays for YKT6

    Primer
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    In Situ
    Assay Products:     
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    Orthologs
    for YKT6 gene

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section
    This gene was present in the common ancestor of eukaryotes.

    Orthologs for YKT6 gene from 10/35 species (see all 35)    About this table
    Organism Taxonomic
    classification    		 Gene Description Human
    Similarity    		 Orthology
    Type    		 Details
    mouse
    (Mus musculus)    		 Mammalia Ykt61 , 5 YKT6 homolog (S. Cerevisiae)1, 5 89.06(n)1
    92.93(a)1    		   11 (3.89 cM)5
    564181  NM_019661.41  NP_062635.21 
     59556935 
    chicken
    (Gallus gallus)    		 Aves YKT61 YKT6 v-SNARE homolog (S. cerevisiae) 78.28(n)
    86.36(a)    		   430371  NM_001113744.1  NP_001107216.1 
    lizard
    (Anolis carolinensis)    		 Reptilia YKT66
    		 --
    		 87(a)
    		 1 ↔ 1
    		 GL343238.1(389854-395867)
    African clawed frog
    (Xenopus laevis)    		 Amphibia LOC3980342 isoprenylated v-SNARE protein 76.51(n)    AF067648.1 
    zebrafish
    (Danio rerio)    		 Actinopterygii zgc555362 similar to prenylated SNARE protein 77.88(n)   394067  AY391470.1 
    fruit fly
    (Drosophila melanogaster)    		 Insecta CG15153
    Ykt61    		 SNAP receptor3
    CG1515-PA1    		 61(a)3
    57.31(n)1
    61.73(a)1    		   7C33
    317061  NM_132195.21  NP_572423.11 
    worm
    (Caenorhabditis elegans)    		 Secernentea B0361.103
    ykt-61    		 synaptobrevin3
    Protein YKT-61    		 56(a)3
    58.97(n)1
    57.44(a)1    		   III(7358173-7359293)3
    1760311  NM_066204.31  NP_498605.11 
    baker's yeast
    (Saccharomyces cerevisiae)    		 Saccharomycetes YKT6(YKL196C)4
    YKT61    		 Vesicle membrane protein (v-SNARE) with acyltransferase activity; involved in trafficking to and within the Golgi, endocytic trafficking to the vacuole, and vacuolar fusion; membrane localization due to prenylation at the carboxy-terminus less4
    Ykt6p1    		 53.7(n)1
    47.47(a)1    		   11(75534-74932)4
    8536381, 4  NP_012725.11, 4 
    thale cress
    (Arabidopsis thaliana)    		 eudicotyledons YKT611 VAMP-like protein YKT61 52.67(n)
    47.51(a)    		   835918  NM_001161313.1  NP_001154785.1 
    rice
    (Oryza sativa)    		 Liliopsida Os01g08663001 hypothetical protein 52.25(n)
    45.95(a)    		   4325070  NM_001051440.1  NP_001044905.1 


    ENSEMBL Gene Tree for YKT6 (if available)
    TreeFam Gene Tree for YKT6 (if available) 

    Paralogs
    for YKT6 gene

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for YKT6 gene

    YKT6 for paralogs           About GeneDecksing


    1 Pseudogenes.org Pseudogene for YKT6
    PGOHUM00000243435


    Genomic Variants
    for YKT6 gene

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/264 NCBI SNPs in YKT6 are shown (see all 264)     About this table
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance    		Chr 7 posSequence#AA
    Chg    		TypeMore#Allele
    freq    		PopTotal
    sample    		More
    ----------
    rs1861207911,2
    		--44238662(+) AGATCA/CGATGC 1 -- us2k10--------
    rs1894304931,2
    		--44238711(+) GTTCCA/TTTGCT 1 -- us2k10--------
    rs47242921,2
    		C--44238780(+) TAGTTT/AGAAGT 1 -- us2k11Minor allele frequency- A:0.50NA 2
    rs47242931,2
    		C--44238805(+) CCTCCG/AGCTTT 1 -- us2k11Minor allele frequency- A:0.50NA 2
    rs1499516701,2
    		--44239034(+) TCATTA/GAGCAG 1 -- us2k10--------
    rs1864702621,2
    		--44239368(+) TGCCCA/TGGCCA 1 -- us2k10--------
    rs77808901,2
    		C--44239524(+) atacgG/Tcccat 1 -- us2k10--------
    rs1830354331,2
    		--44239596(+) TCTGCA/GTCTAT 1 -- us2k10--------
    rs1504866631,2
    		--44239715(+) ATCATA/GGTGGA 1 -- us2k10--------
    rs584446631,2
    		C,F--44239833(+) TCTCTC/TTGCCA 1 -- us2k11Minor allele frequency- T:0.04WA 118

    HapMap Linkage Disequilibrium report for YKT6 (44240567 - 44253893 bp)
    Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
    Database of Genomic Variants (DGV): 1 variation for YKT6
         1 CNV: 4532

    SABiosciences Cancer Mutation PCR Assays
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    Disorders / Diseases
    for YKT6 gene

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    YKT6 for disorders           About GeneDecksing

    OMIM gene information: 606209    OMIM disorders: --

    3 diseases for YKT6:    About MalaCards
    tetanus    breast cancer    malaria


    Export disorders for YKT6 gene to outside databases

    Publications
    for YKT6 gene

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for YKT6 gene, integrated from 9 sources (see all 27):
    (articles sorted by number of sources associating them with YKT6)    		    Utopia: connect your pdf to the dynamic
    world of online information

    1. The human SNARE protein Ykt6 mediates its own palmitoylation at C- terminal cysteine residues. (PubMed id 15479160)1, 2, 3, 9 Veit M. (2004)
    2. Localization and activity of the SNARE Ykt6 determined by its regulatory domain and palmitoylation. (PubMed id 15044687)1, 2, 9 Fukasawa M.... Rothman J.E. (2004)
    3. Participation of the syntaxin 5/Ykt6/GS28/GS15 SNARE complex in transport from the early/recycling endosome to the trans-Golgi network. (PubMed id 15215310)1, 2, 9 Tai G.... Hong W. (2004)
    4. Longins and their longin domains: regulated SNAREs and multifunctional SNARE regulators. (PubMed id 15544955)1, 3 Rossi V....Filippini F. (2004)
    5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    6. Ykt6p, a prenylated SNARE essential for endoplasmic reticulum-Golgi transport. (PubMed id 9211930)1, 2 McNew J.A.... Soellner T.H. (1997)
    7. GS15 forms a SNARE complex with syntaxin 5, GS28, and Ykt6 and is implicated in traffic in the early cisternae of the Golgi apparatus. (PubMed id 12388752)1, 9 Xu Y....Hong W. (2002)
    8. A census of human soluble protein complexes. (PubMed id 22939629)1 Havugimana P.C....Emili A. (2012)
    9. Initial characterization of the human central proteome. (PubMed id 21269460)2 Burkard T.R.... Colinge J. (2011)
    10. A proteome-wide, quantitative survey of in vivo ubiqui tylation sites reveals widespread regulatory roles. (PubMed id 21890473)1 Wagner S.A....Choudhary C. (2011)

    External Searches for YKT6 gene

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
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      Query String
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    OMIM
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    Genome Databases showing YKT6 gene

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 10652 HGNC: 16959 AceView: YKT6 Ensembl:ENSG00000106636 euGenes: HUgn10652
    ECgene: YKT6 Kegg: 10652 H-InvDB: YKT6

    Other Databases showing YKT6 gene

    (According to HUGE)
    About This Section
    		   --

    Specialized Databases showing YKT6 gene

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for YKT6 Pharmacogenomics, SNPs, Pathways

    Intellectual Property
    for YKT6 gene

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    		Patent Information for YKT6 gene:
    Search GeneIP for patents involving YKT6

    GeneCards and IP:
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