 |
 | Services
| |
 |
Aliases & Descriptions for YKT6
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc
, and/or 7Ensembl,
8miRBase) About This Section
|
| Aliases |
|---|
| EC 2.3.1.- 3 | | R-SNARE 2 |
| | | Descriptions |
|---|
| SNARE protein Ykt6 2 | | YKT6 v-SNARE homolog (S. cerevisiae) 2 | | YKT6 v-SNARE protein 2 | | YKT6, S. cerevisiae, homolog of 2 |
|
| | Search outside databases for aliases for YKT6 genePrevious GC identifers: GC07P043887 GC07P043981 GC07P044013 |
Summaries for YKT6(According to Entrez Gene,
Wikipedia's
Gene Wiki,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
| EntrezGene summary for YKT6: This gene product is one of the SNARE recognition molecules implicated in vesicular transport between secretory compartments. It is a membrane associated, isoprenylated protein that functions at the endoplasmic reticulum-Golgi transport step. This protein is highly conserved from yeast to human and can functionally complement the loss of the yeast homolog in the yeast secretory pathway. [provided by RefSeq] UniProtKB/Swiss-Prot: YKT6_HUMAN, O15498Function: Vesicular soluble NSF attachment protein receptor (v-SNARE) mediating vesicle docking and fusion to a specific acceptor cellular compartment. Functions in endoplasmic reticulum to Golgi transport; as part of a SNARE complex composed of GOSR1, GOSR2 and STX5. Functions in early/recycling endosome to TGN transport; as part of a SNARE complex composed of BET1L, GOSR1 and STX5. Has a S-palmitoyl transferase activityGene Wiki entry for YKT6 |
Genomic Location for YKT6
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 36),
and/or miRBase,
Genomic Views according to
UCSC and
Ensembl,
Transcription factor binding sites according to
SABiosciences) About This Section
| Genomic View: UCSC Golden Path with GeneCards custom track
Transcription factor binding sites upstream to the YKT6 gene 
Entrez Gene cytogenetic band: 7p15.1 Ensembl cytogenetic band: 7p13 HGNC cytogenetic band: 7p13YKT6 Gene in genomic location: bands according to Ensembl, locations according to
(and/or Entrez Gene and/or Ensembl if different)
 GeneLoc gene densities for chromosome 7 GeneLoc Exon Structure GeneLoc location for GC07P044207:
(about GC identifiers)
Start:
|
44,207,103 bp from pter |
End:
|
44,220,418 bp from pter |
Size:
|
13,316 bases |
Orientation:
|
plus strand |
1 alternative location:
| Chr7+,CRA_TCAG 44,280,084-44,293,399 |
RefSeq DNA sequence:- NC_000007.12 NT_007819.16 NT_079592.2
| Proteins for YKT6
(According to
1UniProtKB,
and/or Ensembl,
Phosphorylation sites according to 2Phosphosite,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from Invitrogen,
Millipore,
Sigma-Aldrich,
R&D Systems,
Enzo Life Sciences,
Abnova,
OriGene and/or,
Abcam,
Biochemical Assays by
Invitrogen,
Millipore,
R&D Systems,
Cell Signaling Technology, and/or
Enzo Life Sciences,
Ontologies according to Gene
Ontology Consortium 01 Apr 2009 and
Entrez Gene,
Antibodies by Invitrogen,
Millipore,
Sigma-Aldrich,
R&D Systems,
Cell Signaling Technology,
Abcam,
Abnova, and/or
Novus Biologicals)
About This Section
| UniProtKB/Swiss-Prot: YKT6_HUMAN, O15498 (See
protein sequence)Recommended Name: Synaptobrevin homolog YKT6 Size: 198 amino acids; 22418 Da
Subunit: Identified in 2 different SNARE complexes; the first one composed of GOSR1, GOSR2 and STX5 and the second one composed of BET1L, GOSR1 and STX5 (By similarity)
Subcellular location: Cytoplasm, cytosol. Cytoplasmic vesicle membrane; Lipid-anchor; Cytoplasmic side. Golgi apparatus membrane; Lipid-anchor; Cytoplasmic side. Note=Probably cycles through vesicles between Golgi and endosomes
Secondary accessions: Q53F01 Q6FGU9 Q6IB15Post-translational modifications:
Palmitoylated; catalyzes its own palmitoylation. Palmitoylation is required for Golgi targeting1
Farnesylation is required for Golgi targeting1
REFSEQ proteins: NP_006546.1
ENSEMBL proteins: ENSP00000223369
Human Recombinant Proteins               OriGene Purified Recombinant Human Protein: YKT6 
5/10 Gene Ontology (GO) cellular component terms (links to tree view) (see all 10
): About this table
Antibodies for YKT6: Assays for YKT6: | Protein
Domains/ Families for YKT6(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
| - Graphical View of Domain Structure for InterPro Entry O15498
ProtoNet protein and cluster: O15498 1 Blocks protein family: IPB001388 Synaptobrevin
UniProtKB/Swiss-Prot: YKT6_HUMAN, O15498Domain: The longin domain regulates palmitoylation and membrane targetingSimilarity: Belongs to the synaptobrevin familySimilarity: Contains 1 longin domainSimilarity: Contains 1 v-SNARE coiled-coil homology domain | Gene Function for YKT6
(According to MGI Jun 06 2009, UniProtKB,
IUBMB,and/or Genatlas,
shRNA from
OriGene,
Sigma-Aldrich, RNAi from
Sigma-Aldrich,
RNAi Products,
Clones, and
Q-PCR Products
from Invitrogen,
Millipore,
OriGene, and/or
Abnova,
siRNAs from
Applied Biosystems,
SYBR primers from OriGene,
Cell-based Assays from Millipore,
Ontologies according to Gene Ontology Consortium 01 Apr 2009 via
Entrez Gene.)
About This Section
|               OriGene 29mer shRNA kit in GFP-retroviral vector: NM_006555
Applied Biosystems Silencer® siRNAs for YKT6
Sigma-Aldrich siRNA for YKT6  Sigma-Aldrich shRNA for YKT6  Explore Sigma-Aldrich super-pooled esiRNAs 
              OriGene GFP tagged cDNA clone in CMV expression vector: NM_006555                                  Myc/DDK tagged cDNA clone in CMV expression vector: NM_006555                                  untagged cDNA clone in CMV expression vector: NM_006555 
Primers: Browse
Quantitative PCR Central at Invitrogen for Q-PCR LUX™ Primers               OriGene genome-wide validated SYBR primer pairs: NM_006555
UniProtKB/Swiss-Prot: YKT6_HUMAN, O15498Function: Vesicular soluble NSF attachment protein receptor (v-SNARE) mediating vesicle docking and fusion to a specific acceptor cellular compartment. Functions in endoplasmic reticulum to Golgi transport; as part of a SNARE complex composed of GOSR1, GOSR2 and STX5. Functions in early/recycling endosome to TGN transport; as part of a SNARE complex composed of BET1L, GOSR1 and STX5. Has a S-palmitoyl transferase activityEnzyme Number (IUBMB): EC 2.3.1.- 3 Gene Ontology (GO) molecular function terms (links to tree view): About this table | Pathways & Interactions for YKT6
(Pathways according to Invitrogen
(maps by GeneGo),
Millipore,
Cell Signaling Technology,
Sigma-Aldrich,
KEGG
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Proteins Network according to
SABiosciences,
Interactions according to 1UniProtKB,
2MINT, and/or
3STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Apr 2009 via
Entrez Gene.)
About This Section
| 1 Sigma-Aldrich "Your Favorite Gene" Pathway for YKT6 (Your Favorite Gene powered by Ingenuity) 
Gene Network CentralTM Interacting Genes and Proteins Network for YKT6 
5/18 Interacting proteins for YKT6 (ENSP000002233693) via UniProtKB, MINT, and/or STRING (see all 18
)About this table
5 Gene Ontology (GO) biological process terms (links to tree view): About this table
|
Drugs & Compounds for YKT6(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
Sigma-Aldrich, Tocris Bioscience, and/or
Novoseek and Drugs according to
Enzo Life Sciences and/or
PharmGKB)
About This Section
|
Browse Tocris compounds for YKT6
|
Transcripts for YKT6(GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 219 Homo sapiens; Jun 2 2009) or GenBank, RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
non coding RNAs according to
RNAdb,
ESTs according to GeneTide,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from Invitrogen,
Millipore, and/or
Abnova,
siRNAs from Applied Biosystems,
Sigma-Aldrich,
shRNA from
Sigma-Aldrich,
OriGene,
Tagged/untagged cDNA clones from
OriGene, Expression Assays from Applied Biosystems) About This Section
|               OriGene 29mer shRNA kit in GFP-retroviral vector: NM_006555
Sigma-Aldrich siRNA for YKT6  Sigma-Aldrich shRNA for YKT6  Explore Sigma-Aldrich super-pooled esiRNAs 
Applied Biosystems Silencer® siRNAs: NM_006555 REFSEQ mRNAs for YKT6 gene: NM_006555.3
Applied Biosystems TaqMan ® Gene Expression Assays: NM_006555               OriGene GFP tagged cDNA clone in CMV expression vector: NM_006555                                  Myc/DDK tagged cDNA clone in CMV expression vector: NM_006555                                  untagged cDNA clone in CMV expression vector: NM_006555  Additional cDNA sequence: AB451317.1 AB451447.1 AF091079.1 AK075018.1 AK223488.1 AK299158.1 AK312622.1 BC007319.2 BT007078.1 CR456989.1 CR542008.1 CR617047.1 U95735.1 21 DOTS entries: DT.100825169 DT.317823 DT.101956730 DT.100825168 DT.95239327 DT.92456279 DT.95265602 DT.121097123 DT.100008256 DT.100044674 DT.121096981 DT.95265587 DT.100044673 DT.121096976 DT.92456277 DT.95265597 DT.95265603 DT.95348990 DT.121096974 DT.95265590 DT.95265601 24/567 AceView cDNA sequences (see all 567
):AW081630 BQ879059 BM908559 BE265205 CA439756 AW027293 BE407827 BQ215883 BM561271 BQ005651 BQ949804 BM719475 CK823099 BM563231 BU859934 BE792077 AW963959 AI910114 BM684619 AA535242 AI564908 BM828311 AW016223 BQ100874
highest scoring ESTs for YKT6:AA167715 U95735 AA011657 AA011672 AA026067 AA026068 AA037831 AA037832 AA045591 AA045592 Unigene Cluster for YKT6: YKT6 v-SNARE homolog (S. cerevisiae) Hs.520794 [show with all ESTs]Unigene Representative Sequence: NM_006555
GeneLoc Exon Structure
5/6 Alternative Splicing Database (ASD) splice patterns (SP) for YKT6 (see all 6
)
| ExUns: | 1a | · | 1b | ^ | 2a | · | 2b | ^ | 3 | ^ | 4a | · | 4b | ^ | 5a | · | 5b | ^ | 6a | · | 6b | ^ | 7 | ^ | 8a | · | 8b | · | 8c | · | 8d | |
| SP1: | |   | |   | |   | |   | |   | - |   | |   | |   | - |   | - |   | |   | - |   | |   | |   | |   | |   | |
| SP2: | |   | |   | |   | |   | |   | - |   | |   | |   | - |   | - |   | - |   | - |   | |   | |   | |   | |   | |
| SP3: | |   | |   | |   | |   | |   | |   | |   | |   | - |   | - |   | |   | |   | |   | |   | |   | |   | |
| SP4: | |   | |   | - |   | |   | |   | - |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |
| SP5: | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | - |   | |   | |   | |   | |   |
About this scheme
ECgene alternative splicing isoforms for YKT6
1 Ensembl transcript including schematic representation: ENST00000223369
|
Expression for YKT6
(Experimental results according to
1GeneNote
and GNF BioGPS,
probe sets-to-genes annotations according to
2GeneAnnot ,
3GeneTide ,
Sets of similar genes according to GeneDecks,
Electronic Northern calculations according to data from
UniGene (Build 219 Homo sapiens),
SAGE tags according to
CGAP,
plus additional links to
SOURCE, and/or
GNF
BioGPS, and/or
EXPOLDB, and/or
UniProtKB,
Expression Assays from
Applied Biosystems
)
About This Section
| YKT6 expression in normal and diseased human tissues
Applied Biosystems TaqMan ® Gene Expression Assays for YKT6
1 / 2 / 3 7 probe-sets matching YKT6 gene Data from
(Publications) and GNF BioGPS About these images About these images
CGAP SAGE TAG: TCATTTTCCT
SOURCE GeneReport for Unigene cluster: Hs.520794
Expression variation in blood from EXPOLDB for YKT6 |
Orthologs for YKT6
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
and/or
5MGI Jun 06 2009,
with possible further links to
Flybase
and/or
WormBase,
Gene Trees according to Ensembl)
About This Section
|
Orthologs for YKT6 gene from 5/22 species (see all 22
)
About this table Species with no ortholog for YKT6
ENSEMBL Gene Tree for YKT6 | Paralogs for YKT6(Paralogs according to 1HomoloGene and 2Ensembl, Pseudogenes according to 3Pseudogene.org) About This Section
| -- |
SNPs/Variants for YKT6(According to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE, and
UniProtKB,
Linkage Disequilibrium by HapMap,
Genotyping Reagents from
Applied Biosystems)
About This Section
|
HapMap Linkage Disequilibrium images for YKT6 (up to first 250kb)
|
Disorders & Mutations for YKT6
(in which this Gene is Involved, According to
OMIM, UniProtKB,
PharmGKB,
Genatlas, GeneTests,
Blood group antigen gene mutations by BGMUT,
HGMD, GAD,
HuGE Navigator,
BCGD,
and/or TGDB.)
About This Section
|
OMIM: 606209
|
Medical News for YKT6(Possibly Related Articles in
Doctor's Guide)
About This Section
| -- |
Publications for YKT6 (in
PubMed.
Associations of this gene to articles via
1Novoseek,
2HGNC,
3Entrez Gene,
4UniProtKB/Swiss-Prot,
5UniProtKB/TrEMBL,
6GAD, and/or
7PharmGKB)
About This Section
| 10/19 PubMed articles for YKT6 gene (see all 19
):- The human SNARE protein Ykt6 mediates its own palmitoylation at C- terminal cysteine residues. (PubMed id 15479160)1, 2, 3, 4 Veit M. (2004)
- Localization and activity of the SNARE Ykt6 determined by its regulatory domain and palmitoylation. (PubMed id 15044687)1, 3, 4 Fukasawa M.... Rothman J.E. (2004)
- Participation of the syntaxin 5/Ykt6/GS28/GS15 SNARE complex in transport from the early/recycling endosome to the trans-Golgi network. (PubMed id 15215310)1, 3, 4 Tai G.... Hong W. (2004)
- Longins and their longin domains: regulated SNAREs and multifunctional SNARE regulators. (PubMed id 15544955)2, 3 Rossi V....Filippini F. (2004)
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)3, 4 Gerhard D.S....Malek J. (2004)
- Ykt6p, a prenylated SNARE essential for endoplasmic reticulum-Golgi transport. (PubMed id 9211930)3, 4 McNew J.A.... Soellner T.H. (1997)
- GS15 forms a SNARE complex with syntaxin 5, GS28, and Ykt6 and is implicated in traffic in the early cisternae of the Golgi apparatus. (PubMed id 12388752)1, 3 Xu Y....Hong W. (2002)
- Possible involvement of CCT5, RGS3, and YKT6 genes up-regulated in p53-mutated tumors in resistance to docetaxel in human breast cancers. (PubMed id 16821082)3 Ooe A....Noguchi S. (2007)
- Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. (PubMed id 16344560)3 Kimura K.... Sugano S. (2006)
- Involvement of a novel Q-SNARE, D12, in quality control of the endomembrane system. (PubMed id 16354670)3 Okumura A.J....Wada I. (2006)
|
Search for YKT6
(in PubMed,
OMIM, and NCBI Bookshelf) About This Section
|
|
Genome Databases showing YKT6
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
and/or
H-InvDB)
About This Section
|
| Other Databases showing YKT6
(According to HUGE)
About This Section
| -- |
Specialized Databases showing YKT6(According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL, Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot) About This Section
|
| About This Section
| --
| Services for YKT6(Reagents available from Applied Biosystems, Antibodies and assays by Cell
Signaling Technology, Abcam, Novus Biologicals, Sigma-Aldrich, R&D Systems, Millipore, Abnova, and/or Invitrogen, Clones available from OriGene,and/or Invitrogen, Drugs and/or compounds by Sigma-Aldrich, Enzo Life Sciences, and/or Tocris Bioscience) About This Section
| 
 Products for YKT6:

 | |
 | | | | |
|
 |  |  |
| | Recombinant Proteins (YKT6) | | Antibodies (YKT6) |
| | | Search Tocris compounds for YKT6 |
|
 |
 | | | |
GeneCards Homepage - Last full update: 2 Jul 2009
Incremental update: 13 Oct 2009
|