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Aliases for YKT6 Gene

Aliases for YKT6 Gene

  • YKT6 V-SNARE Homolog (S. Cerevisiae) 2 3 5
  • R-SNARE 2 3
  • YKT6, S. Cerevisiae, Homolog Of 3
  • YKT6 V-SNARE Protein 3
  • SNARE Protein Ykt6 3
  • EC 2.3.1.- 4
  • EC 2.3.1 63

External Ids for YKT6 Gene

Previous GeneCards Identifiers for YKT6 Gene

  • GC07P043887
  • GC07P043981
  • GC07P044013
  • GC07P044207

Summaries for YKT6 Gene

Entrez Gene Summary for YKT6 Gene

  • This gene product is one of the SNARE recognition molecules implicated in vesicular transport between secretory compartments. It is a membrane associated, isoprenylated protein that functions at the endoplasmic reticulum-Golgi transport step. This protein is highly conserved from yeast to human and can functionally complement the loss of the yeast homolog in the yeast secretory pathway. [provided by RefSeq, Jul 2008]

GeneCards Summary for YKT6 Gene

YKT6 (YKT6 V-SNARE Homolog (S. Cerevisiae)) is a Protein Coding gene. Among its related pathways are Nicotine Pathway (Dopaminergic Neuron), Pharmacodynamics and Transport to the Golgi and subsequent modification. GO annotations related to this gene include SNARE binding and protein-cysteine S-palmitoyltransferase activity.

UniProtKB/Swiss-Prot for YKT6 Gene

  • Vesicular soluble NSF attachment protein receptor (v-SNARE) mediating vesicle docking and fusion to a specific acceptor cellular compartment. Functions in endoplasmic reticulum to Golgi transport; as part of a SNARE complex composed of GOSR1, GOSR2 and STX5. Functions in early/recycling endosome to TGN transport; as part of a SNARE complex composed of BET1L, GOSR1 and STX5. Has a S-palmitoyl transferase activity.

Gene Wiki entry for YKT6 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for YKT6 Gene

Genomics for YKT6 Gene

Regulatory Elements for YKT6 Gene

Enhancers for YKT6 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around YKT6 on UCSC Golden Path with GeneCards custom track

Promoters for YKT6 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around YKT6 on UCSC Golden Path with GeneCards custom track

Genomic Location for YKT6 Gene

Chromosome:
7
Start:
44,200,968 bp from pter
End:
44,214,294 bp from pter
Size:
13,327 bases
Orientation:
Plus strand

Genomic View for YKT6 Gene

Genes around YKT6 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
YKT6 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for YKT6 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for YKT6 Gene

Proteins for YKT6 Gene

  • Protein details for YKT6 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    O15498-YKT6_HUMAN
    Recommended name:
    Synaptobrevin homolog YKT6
    Protein Accession:
    O15498
    Secondary Accessions:
    • B4DR94
    • Q53F01
    • Q6FGU9
    • Q6IB15

    Protein attributes for YKT6 Gene

    Size:
    198 amino acids
    Molecular mass:
    22418 Da
    Quaternary structure:
    • Identified in 2 different SNARE complexes; the first one composed of GOSR1, GOSR2 and STX5 and the second one composed of BET1L, GOSR1 and STX5.

    Alternative splice isoforms for YKT6 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for YKT6 Gene

Proteomics data for YKT6 Gene at MOPED

Selected DME Specific Peptides for YKT6 Gene

Post-translational modifications for YKT6 Gene

  • Farnesylation is required for Golgi targeting.
  • Palmitoylated; catalyzes its own palmitoylation. Palmitoylation is required for Golgi targeting.
  • Ubiquitination at Lys 182
  • Modification sites at PhosphoSitePlus

Other Protein References for YKT6 Gene

ENSEMBL proteins:
REFSEQ proteins:

Domains & Families for YKT6 Gene

Gene Families for YKT6 Gene

Protein Domains for YKT6 Gene

Graphical View of Domain Structure for InterPro Entry

O15498

UniProtKB/Swiss-Prot:

YKT6_HUMAN :
  • The longin domain regulates palmitoylation and membrane targeting.
  • Belongs to the synaptobrevin family.
Domain:
  • The longin domain regulates palmitoylation and membrane targeting.
  • Contains 1 longin domain.
  • Contains 1 v-SNARE coiled-coil homology domain.
Family:
  • Belongs to the synaptobrevin family.
genes like me logo Genes that share domains with YKT6: view

Function for YKT6 Gene

Molecular function for YKT6 Gene

UniProtKB/Swiss-Prot Function:
Vesicular soluble NSF attachment protein receptor (v-SNARE) mediating vesicle docking and fusion to a specific acceptor cellular compartment. Functions in endoplasmic reticulum to Golgi transport; as part of a SNARE complex composed of GOSR1, GOSR2 and STX5. Functions in early/recycling endosome to TGN transport; as part of a SNARE complex composed of BET1L, GOSR1 and STX5. Has a S-palmitoyl transferase activity.

Enzyme Numbers (IUBMB) for YKT6 Gene

genes like me logo Genes that share phenotypes with YKT6: view

Animal Model Products

No data available for Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for YKT6 Gene

Localization for YKT6 Gene

Subcellular locations from UniProtKB/Swiss-Prot for YKT6 Gene

Cytoplasm, cytosol. Cytoplasmic vesicle membrane; Lipid-anchor; Cytoplasmic side. Golgi apparatus membrane; Lipid-anchor; Cytoplasmic side. Note=Probably cycles through vesicles between Golgi and endosomes.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for YKT6 Gene COMPARTMENTS Subcellular localization image for YKT6 gene
Compartment Confidence
cytosol 5
endoplasmic reticulum 5
endosome 5
extracellular 5
golgi apparatus 5
mitochondrion 5
plasma membrane 4
vacuole 2
lysosome 1
nucleus 1

Gene Ontology (GO) - Cellular Components for YKT6 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000139 Golgi membrane TAS --
GO:0005829 cytosol IEA --
GO:0005887 integral component of plasma membrane IDA 9211930
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with YKT6: view

Pathways & Interactions for YKT6 Gene

genes like me logo Genes that share pathways with YKT6: view

Gene Ontology (GO) - Biological Process for YKT6 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006810 transport IEA --
genes like me logo Genes that share ontologies with YKT6: view

No data available for SIGNOR curated interactions for YKT6 Gene

Drugs & Compounds for YKT6 Gene

(1) Drugs for YKT6 Gene - From: Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
genes like me logo Genes that share compounds with YKT6: view

Transcripts for YKT6 Gene

Unigene Clusters for YKT6 Gene

YKT6 v-SNARE homolog (S. cerevisiae):
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for YKT6 Gene

ExUns: 1a · 1b ^ 2a · 2b ^ 3 ^ 4a · 4b ^ 5a · 5b ^ 6a · 6b ^ 7 ^ 8a · 8b · 8c · 8d
SP1: - - - -
SP2: - - - - -
SP3: - -
SP4: - -
SP5: -
SP6:

Relevant External Links for YKT6 Gene

GeneLoc Exon Structure for
YKT6
ECgene alternative splicing isoforms for
YKT6

Expression for YKT6 Gene

mRNA expression in normal human tissues for YKT6 Gene

Protein differential expression in normal tissues from HIPED for YKT6 Gene

This gene is overexpressed in Colon muscle (10.8).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for YKT6 Gene



SOURCE GeneReport for Unigene cluster for YKT6 Gene Hs.520794

genes like me logo Genes that share expression patterns with YKT6: view

Protein tissue co-expression partners for YKT6 Gene

Primer Products

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for YKT6 Gene

Orthologs for YKT6 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for YKT6 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia YKT6 35
  • 89.23 (n)
  • 92.93 (a)
YKT6 36
  • 93 (a)
OneToOne
dog
(Canis familiaris)
Mammalia YKT6 35
  • 88.1 (n)
  • 93.45 (a)
-- 36
  • 64 (a)
OneToMany
-- 36
  • 87 (a)
OneToMany
mouse
(Mus musculus)
Mammalia Ykt6 35
  • 89.06 (n)
  • 92.93 (a)
Ykt6 16
Ykt6 36
  • 93 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia YKT6 35
  • 99.83 (n)
  • 100 (a)
YKT6 36
  • 100 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Ykt6 35
  • 90.4 (n)
  • 94.95 (a)
oppossum
(Monodelphis domestica)
Mammalia YKT6 36
  • 92 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia YKT6 36
  • 80 (a)
OneToOne
chicken
(Gallus gallus)
Aves YKT6 35
  • 78.28 (n)
  • 86.36 (a)
YKT6 36
  • 85 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia YKT6 36
  • 85 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia MGC76008 35
ykt6 35
  • 75.08 (n)
  • 87.88 (a)
African clawed frog
(Xenopus laevis)
Amphibia LOC398034 35
zebrafish
(Danio rerio)
Actinopterygii ykt6 35
  • 76.09 (n)
  • 84.85 (a)
zgc55536 35
ykt6 36
  • 84 (a)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta CG1515 37
  • 61 (a)
Ykt6 35
  • 57.36 (n)
  • 61.42 (a)
Ykt6 36
  • 60 (a)
OneToOne
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP000392 35
  • 62.05 (n)
  • 63.08 (a)
worm
(Caenorhabditis elegans)
Secernentea B0361.10 37
  • 56 (a)
ykt-6 35
  • 58.97 (n)
  • 57.44 (a)
ykt-6 36
  • 55 (a)
OneToOne
A. gosspyii yeast
(Ashbya gossypii)
Saccharomycetes AGOS_AER109W 35
  • 53.87 (n)
  • 47.47 (a)
K. lactis yeast
(Kluyveromyces lactis)
Saccharomycetes KLLA0D02684g 35
  • 52.02 (n)
  • 47.98 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes YKT6 35
  • 53.7 (n)
  • 47.47 (a)
YKT6 36
  • 46 (a)
OneToOne
YKT6 38
rice
(Oryza sativa)
Liliopsida Os01g0866300 35
  • 52.25 (n)
  • 45.95 (a)
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.1746 35
bread mold
(Neurospora crassa)
Ascomycetes NCU08973 35
  • 53.06 (n)
  • 45.41 (a)
fission yeast
(Schizosaccharomyces pombe)
Schizosaccharomycetes ykt6 35
  • 52.55 (n)
  • 54.59 (a)
Species with no ortholog for YKT6:
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for YKT6 Gene

ENSEMBL:
Gene Tree for YKT6 (if available)
TreeFam:
Gene Tree for YKT6 (if available)

Paralogs for YKT6 Gene

Pseudogenes.org Pseudogenes for YKT6 Gene

genes like me logo Genes that share paralogs with YKT6: view

No data available for Paralogs for YKT6 Gene

Variants for YKT6 Gene

Sequence variations from dbSNP and Humsavar for YKT6 Gene

SNP ID Clin Chr 07 pos Sequence Context AA Info Type
rs917793 -- 44,206,254(-) GCAAG(A/T)CTTGT intron-variant
rs1004558 -- 44,200,808(-) CTTGT(A/G)CTGGG upstream-variant-2KB
rs1045776 -- 44,213,786(+) AGGAC(C/T)CCACC utr-variant-3-prime
rs1476892 -- 44,204,354(-) TACCT(A/G)GCTCA intron-variant
rs12670584 -- 44,212,419(+) TCCTG(C/G/T)GAGAA utr-variant-3-prime

Structural Variations from Database of Genomic Variants (DGV) for YKT6 Gene

Variant ID Type Subtype PubMed ID
nsv8082 CNV Gain 18304495
nsv830983 CNV Loss 17160897
nsv509195 CNV Insertion 20534489
nsv887998 CNV Loss 21882294

Variation tolerance for YKT6 Gene

Residual Variation Intolerance Score: 58.7% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.69; 14.68% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for YKT6 Gene

HapMap Linkage Disequilibrium report
YKT6

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for YKT6 Gene

Disorders for YKT6 Gene

Relevant External Links for YKT6

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
YKT6

No disorders were found for YKT6 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for YKT6 Gene

Publications for YKT6 Gene

  1. The human SNARE protein Ykt6 mediates its own palmitoylation at C- terminal cysteine residues. (PMID: 15479160) Veit M. (Biochem. J. 2004) 2 3 4 23 67
  2. Longins and their longin domains: regulated SNAREs and multifunctional SNARE regulators. (PMID: 15544955) Rossi V. … Filippini F. (Trends Biochem. Sci. 2004) 2 3
  3. Localization and activity of the SNARE Ykt6 determined by its regulatory domain and palmitoylation. (PMID: 15044687) Fukasawa M. … Rothman J.E. (Proc. Natl. Acad. Sci. U.S.A. 2004) 3 23
  4. Participation of the syntaxin 5/Ykt6/GS28/GS15 SNARE complex in transport from the early/recycling endosome to the trans-Golgi network. (PMID: 15215310) Tai G. … Hong W. (Mol. Biol. Cell 2004) 3 23
  5. GS15 forms a SNARE complex with syntaxin 5, GS28, and Ykt6 and is implicated in traffic in the early cisternae of the Golgi apparatus. (PMID: 12388752) Xu Y. … Hong W. (Mol. Biol. Cell 2002) 3 23

Products for YKT6 Gene

Sources for YKT6 Gene

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