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YKT6 Gene

protein-coding   GIFtS: 60
GCID: GC07P044240

YKT6 V-SNARE Homolog (S. Cerevisiae)

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(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
YKT6 V-SNARE Homolog (S. Cerevisiae)1 2     YKT6 V-SNARE Protein2
R-SNARE1 2     YKT6, S. Cerevisiae, Homolog Of2
SNARE Protein Ykt62     EC 2.3.1.-3
Synaptobrevin Homolog YKT62     EC 2.3.18

External Ids:    HGNC: 169591   Entrez Gene: 106522   Ensembl: ENSG000001066367   OMIM: 6062095   UniProtKB: O154983   

Export aliases for YKT6 gene to outside databases

Previous GC identifers: GC07P043887 GC07P043981 GC07P044013 GC07P044207


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for YKT6 Gene:
This gene product is one of the SNARE recognition molecules implicated in vesicular transport between secretory
compartments. It is a membrane associated, isoprenylated protein that functions at the endoplasmic
reticulum-Golgi transport step. This protein is highly conserved from yeast to human and can functionally
complement the loss of the yeast homolog in the yeast secretory pathway. (provided by RefSeq, Jul 2008)

GeneCards Summary for YKT6 Gene:
YKT6 (YKT6 v-SNARE homolog (S. cerevisiae)) is a protein-coding gene. GO annotations related to this gene include protein-cysteine S-palmitoyltransferase activity and SNAP receptor activity.

UniProtKB/Swiss-Prot: YKT6_HUMAN, O15498
Function: Vesicular soluble NSF attachment protein receptor (v-SNARE) mediating vesicle docking and fusion to a
specific acceptor cellular compartment. Functions in endoplasmic reticulum to Golgi transport; as part of a SNARE
complex composed of GOSR1, GOSR2 and STX5. Functions in early/recycling endosome to TGN transport; as part of a
SNARE complex composed of BET1L, GOSR1 and STX5. Has a S-palmitoyl transferase activity

Gene Wiki entry for YKT6 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000007.13  NT_007819.18  NC_018918.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the YKT6 gene promoter:
         c-Fos   AP-1   ATF-2   SREBP-1c   c-Jun   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 3): YKT6 promoter sequence
   Search Chromatin IP Primers for YKT6

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat YKT6


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 7p15.1   Ensembl cytogenetic band:  7p13   HGNC cytogenetic band: 7p13

YKT6 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
YKT6 gene location

GeneLoc information about chromosome 7         GeneLoc Exon Structure

GeneLoc location for GC07P044240:  view genomic region     (about GC identifiers)

Start:
44,240,567 bp from pter      End:
44,253,893 bp from pter
Size:
13,327 bases      Orientation:
plus strand

1 alternative location:
Chr7+,CRA_TCAG 44,280,084-44,293,399     

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., eBioscience, and/or antibodies-online,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., eBioscience, and/or antibodies-online, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, Cloud-Clone Corp, antibodies-online, and/or others.)
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UniProtKB/Swiss-Prot: YKT6_HUMAN, O15498 (See protein sequence)
Recommended Name: Synaptobrevin homolog YKT6 precursor  
Size: 198 amino acids; 22418 Da
Subunit: Identified in 2 different SNARE complexes; the first one composed of GOSR1, GOSR2 and STX5 and the second
one composed of BET1L, GOSR1 and STX5 (By similarity)
Secondary accessions: Q53F01 Q6FGU9 Q6IB15

Explore the universe of human proteins at neXtProt for YKT6: NX_O15498

Explore proteomics data for YKT6 at MOPED

Post-translational modifications: 

  • Palmitoylated; catalyzes its own palmitoylation. Palmitoylation is required for Golgi targeting1
  • Farnesylation is required for Golgi targeting1
  • Ubiquitination2 at Lys103, Lys182
  • Modification sites at PhosphoSitePlus
  • Selected DME Specific Peptides for YKT6 (O15498) (see all 8)
     ELDETKI  RASVKEQ  QSKAFYK  FTLLEKVL 


    See YKT6 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_006546.1  
    ENSEMBL proteins: 
     ENSP00000420805   ENSP00000223369   ENSP00000412414  

    YKT6 Human Recombinant Protein Products:

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    Cloud-Clone Corp. Proteins for YKT6

     
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    antibodies-online proteins for YKT6 (16 products) 

     
    Search antibodies-online for peptides for YKT6

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    antibodies-online kits for YKT6 (8 products) 


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    3 InterPro protein domains:
     IPR010908 Longin_dom
     IPR011012 Longin-like_dom
     IPR001388 Synaptobrevin

    Graphical View of Domain Structure for InterPro Entry O15498

    ProtoNet protein and cluster: O15498

    1 Blocks protein domain: IPB001388 Synaptobrevin

    UniProtKB/Swiss-Prot: YKT6_HUMAN, O15498
    Domain: The longin domain regulates palmitoylation and membrane targeting
    Similarity: Belongs to the synaptobrevin family
    Similarity: Contains 1 longin domain
    Similarity: Contains 1 v-SNARE coiled-coil homology domain


    Find genes that share domains with YKT6           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: YKT6_HUMAN, O15498
    Function: Vesicular soluble NSF attachment protein receptor (v-SNARE) mediating vesicle docking and fusion to a
    specific acceptor cellular compartment. Functions in endoplasmic reticulum to Golgi transport; as part of a SNARE
    complex composed of GOSR1, GOSR2 and STX5. Functions in early/recycling endosome to TGN transport; as part of a
    SNARE complex composed of BET1L, GOSR1 and STX5. Has a S-palmitoyl transferase activity

         Enzyme Numbers (IUBMB): EC 2.3.12 EC 2.3.1.-1

         Gene Ontology (GO): 3 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000149SNARE binding IBA--
    GO:0005484SNAP receptor activity IDA15215310
    GO:0019706protein-cysteine S-palmitoyltransferase activity IDA15479160
         
    Find genes that share ontologies with YKT6           About GenesLikeMe


    Phenotypes:
         1 GenomeRNAi human phenotype for YKT6:
     Increased gamma-H2AX phosphory 

    Animal Models:
       genOway: Develop your customized and physiologically relevant rodent model for YKT6

    miRNA
    Products:
        
    miRTarBase miRNAs that target YKT6:
    hsa-mir-132-3p (MIRT021756), hsa-mir-708-5p (MIRT037749), hsa-mir-122-5p (MIRT023323), hsa-mir-1296-5p (MIRT036097), hsa-mir-124-3p (MIRT022550), hsa-mir-30d-5p (MIRT047824)

    Block miRNA regulation of human, mouse, rat YKT6 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate YKT6 (see all 9):
    hsa-miR-549 hsa-miR-579 hsa-miR-218-2* hsa-miR-3918 hsa-miR-1257 hsa-miR-129-3p hsa-miR-1207-5p hsa-miR-129*
    SwitchGear 3'UTR luciferase reporter plasmidYKT6 3' UTR sequence
    Inhib. RNA
    Products:
        
    OriGene RNAi products in human, mouse, rat for YKT6
    Predesigned siRNA for gene silencing in human, mouse, rat YKT6

    Gene Editing
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    Sino Biological Human cDNA Clone for YKT6
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    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat YKT6

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    In Situ Assay
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for YKT6


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    YKT6_HUMAN, O15498: Cytoplasm, cytosol. Cytoplasmic vesicle membrane; Lipid-anchor; Cytoplasmic side. Golgi
    apparatus membrane; Lipid-anchor; Cytoplasmic side. Note=Probably cycles through vesicles between Golgi and
    endosomes
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    cytosol5
    golgi apparatus5
    endoplasmic reticulum4
    endosome4
    mitochondrion4
    plasma membrane4
    vacuole2
    extracellular1
    lysosome1
    nucleus1

    Gene Ontology (GO): Selected cellular component terms (see all 12):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000139Golgi membrane IEA--
    GO:0005737cytoplasm IDA--
    GO:0005739mitochondrion IDA--
    GO:0005768endosome IDA15215310
    GO:0005783endoplasmic reticulum IDA9211930

    Find genes that share ontologies with YKT6           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for YKT6 About    
    See pathways by source

    SuperPathContained pathways About
    1Nicotine Pathway (Dopaminergic Neuron), Pharmacodynamics
    Nicotine Pathway (Dopaminergic Neuron), Pharmacodynamics0.44
    SNARE interactions in vesicular transport0.40
    2Clathrin dependent protein traffic
    Transport Clathrin coated vesicle cycle0.66


    Find genes that share SuperPaths with YKT6           About GenesLikeMe

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways


    1 GeneGo (Thomson Reuters) Pathway for YKT6
        Transport Clathrin-coated vesicle cycle


    1 PharmGKB Pathway for YKT6
        Nicotine Pathway (Dopaminergic Neuron), Pharmacodynamics

    1 Kegg Pathway  (Kegg details for YKT6):
        SNARE interactions in vesicular transport

        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for YKT6
    Interactions:

        GeneGlobe Interaction Network for YKT6

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for YKT6 (O154983 ENSP000002233694) via UniProtKB, MINT, STRING, and/or I2D (see all 143)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    USO1O607633, ENSP000004116984I2D: score=4 STRING: ENSP00000411698
    CTPS1P178123, ENSP000003616994I2D: score=3 STRING: ENSP00000361699
    BET1LQ9NYM93, ENSP000003722104I2D: score=2 STRING: ENSP00000372210
    COG3Q96JB23, ENSP000002586544I2D: score=2 STRING: ENSP00000258654
    NAPBQ9H1153, ENSP000003662254I2D: score=2 STRING: ENSP00000366225
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 9):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006810transport ----
    GO:0006888ER to Golgi vesicle-mediated transport IDA9211930
    GO:0006903vesicle targeting IDA9211930
    GO:0006904vesicle docking involved in exocytosis IDA9211930
    GO:0006906vesicle fusion IBA--

    Find genes that share ontologies with YKT6           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for YKT6

    1 Novoseek inferred chemical compound relationship for YKT6 gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    cysteine 34.2 2 15044687 (1), 15479160 (1)



    Find genes that share compounds with YKT6           About GenesLikeMe



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for YKT6 gene: 
    NM_006555.3  

    Unigene Cluster for YKT6:

    YKT6 v-SNARE homolog (S. cerevisiae)
    Hs.520794  [show with all ESTs]
    Unigene Representative Sequence: NM_006555
    7 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000496112 ENST00000447123 ENST00000223369(uc003tkm.3 uc011kbv.2)
    ENST00000463014 ENST00000478411 ENST00000424864 ENST00000421621
    miRNA
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    Selected qRT-PCR Assays for microRNAs that regulate YKT6 (see all 9):
    hsa-miR-549 hsa-miR-579 hsa-miR-218-2* hsa-miR-3918 hsa-miR-1257 hsa-miR-129-3p hsa-miR-1207-5p hsa-miR-129*
    SwitchGear 3'UTR luciferase reporter plasmidYKT6 3' UTR sequence
    Inhib. RNA
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    Clone
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    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: YKT6 (NM_006555)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for YKT6
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat YKT6
    Primer
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    OriGene qPCR primer pairs and template standards for YKT6
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      QuantiTect SYBR Green Assays in human, mouse, rat YKT6
      QuantiFast Probe-based Assays in human, mouse, rat YKT6

    Additional mRNA sequence: 

    AB451317.1 AB451447.1 AF091079.1 AK075018.1 AK223488.1 AK299158.1 AK312622.1 BC007319.2 
    BT007078.1 CR456989.1 CR542008.1 U95735.1 

    21 DOTS entries:

    DT.100825169  DT.317823  DT.101956730  DT.100825168  DT.95239327  DT.92456279  DT.95265602  DT.121097123 
    DT.100008256  DT.100044674  DT.121096981  DT.95265587  DT.100044673  DT.121096976  DT.92456277  DT.95265597 
    DT.95265603  DT.95348990  DT.121096974  DT.95265590  DT.95265601 

    Selected AceView cDNA sequences (see all 567):

    CB137255 CF125402 CK823099 H40165 BI261925 BX483817 BU624350 BM931170 
    BQ069093 BQ878917 BM553341 AA535242 BM684619 BQ674848 AI205634 BU681686 
    AA514224 BI334797 BU501872 F24525 CK823098 CA865891 AI140279 BC007319 

    GeneLoc Exon Structure

    Selected Alternative Splicing Database (ASD) splice patterns (SP) for YKT6 (see all 6)    About this scheme

    ExUns: 1a · 1b ^ 2a · 2b ^ 3 ^ 4a · 4b ^ 5a · 5b ^ 6a · 6b ^ 7 ^ 8a · 8b · 8c · 8d
    SP1:                                -                 -     -           -                           
    SP2:                                -                 -     -     -     -                           
    SP3:                                                  -     -                                       
    SP4:              -                 -                                                               
    SP5:                                                                    -                           


    ECgene alternative splicing isoforms for YKT6

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    YKT6 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: TCATTTTCCT
    YKT6 Expression
    About this image


    YKT6 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 8) fully expand
     
     Brain (Nervous System)    fully expand to see all 4 entries
             Cerebral Cortex
     
     Ovary (Reproductive System)    fully expand to see all 2 entries
             Ovarian Mesenchymal Stroma Cells Ovary Interstitium
             Oviduct
     
     Bone (Muscoskeletal System)
             Bone Marrow
     
     Trophoblast (Extraembryonic Tissues)
             Trophoblast Cells Trophoblast
     
     Testis (Reproductive System)
             Leydig Cells Testis Interstitium
    YKT6 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    YKT6 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.520794
        Custom PCR Arrays for YKT6
    Primer
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    QuantiFast Probe-based Assays in human, mouse, rat YKT6
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for YKT6

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of eukaryotes.

    Orthologs for YKT6 gene from Selected species (see all 23)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Ykt61 , 5 YKT6 homolog (S. Cerevisiae)1, 5 89.06(n)1
    92.93(a)1
      11 (3.89 cM)5
    564181  NM_019661.41  NP_062635.21 
     59556935 
    chicken
    (Gallus gallus)
    Aves YKT61 YKT6 v-SNARE homolog (S. cerevisiae) 78.28(n)
    86.36(a)
      430371  NM_001113744.1  NP_001107216.1 
    lizard
    (Anolis carolinensis)
    Reptilia YKT66
    YKT6 v-SNARE homolog (S. cerevisiae)
    85(a)
    1 ↔ 1
    GL343238.1(389854-395940)
    African clawed frog
    (Xenopus laevis)
    Amphibia LOC3980342 isoprenylated v-SNARE protein 76.51(n)    AF067648.1 
    zebrafish
    (Danio rerio)
    Actinopterygii zgc555362 similar to prenylated SNARE protein 77.88(n)   394067  AY391470.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta CG15153
    Ykt61
    SNAP receptor3
    Ykt61
    61(a)3
    57.36(n)1
    61.42(a)1
      7C33
    317061  NM_132195.31  NP_572423.11 
    worm
    (Caenorhabditis elegans)
    Secernentea B0361.103
    ykt-61
    synaptobrevin3
    ykt-61
    56(a)3
    58.97(n)1
    57.44(a)1
      III(7358173-7359293)3
    1760311  NM_066204.41  NP_498605.11 
    baker's yeast
    (Saccharomyces cerevisiae)
    Saccharomycetes YKT6(YKL196C)4
    YKT61
    Vesicle membrane protein (v-SNARE) with acyltransferase more4
    YKT61
    53.7(n)1
    47.47(a)1
      11(75534-74932)4
    8536381, 4  NP_012725.11, 4 
    rice
    (Oryza sativa)
    Liliopsida Os01g08663001 Os01g0866300 52.25(n)
    45.95(a)
      4325070  NM_001051440.1  NP_001044905.1 


    ENSEMBL Gene Tree for YKT6 (if available)
    TreeFam Gene Tree for YKT6 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for YKT6 gene

    Find genes that share paralogs with YKT6           About GenesLikeMe


    1 Pseudogenes.org Pseudogene for YKT6
    PGOHUM00000243435


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for YKT6 (see all 328)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 7 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1861207911,2
    --44238662(+) AGATCA/CGATGC 1 -- us2k10--------
    rs1894304931,2
    --44238711(+) GTTCCA/TTTGCT 1 -- us2k10--------
    rs47242921,2
    C--44238780(+) tagttT/Agaagt 1 -- us2k11Minor allele frequency- A:0.50NA 2
    rs47242931,2
    C--44238805(+) cctccG/Agcttt 1 -- us2k11Minor allele frequency- A:0.50NA 2
    rs1998968101,2
    C--44238914(+) TTGATA/GGGGAT 1 -- us2k10--------
    rs1499516701,2
    C--44239034(+) TCATTA/GAGCAG 1 -- us2k10--------
    rs1864702621,2
    --44239368(+) TGCCCA/TGGCCA 1 -- us2k10--------
    rs77808901,2
    C--44239524(+) atacgG/Tcccat 1 -- us2k10--------
    rs1830354331,2
    --44239596(+) TCTGCA/GTCTAT 1 -- us2k10--------
    rs1504866631,2
    C--44239715(+) ATCATA/GGTGGA 1 -- us2k10--------

    HapMap Linkage Disequilibrium report for YKT6 (44240567 - 44253893 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 4 variations for YKT6:    About this table    
    Variant IDTypeSubtypePubMed ID
    nsv509195CNV Insertion20534489
    nsv830983CNV Loss17160897
    nsv887998CNV Loss21882294
    nsv8082CNV Gain18304495

    Site Specific Mutation Identification with PCR Assays
    Search QIAGEN SeqTarget long-range PCR primers for resequencing YKT6
    DNA2.0 Custom Variant and Variant Library Synthesis for YKT6

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 606209    OMIM disorders: --


    Find genes that share disorders with YKT6           About GenesLikeMe


    Export disorders for YKT6 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for YKT6 gene, integrated from 10 sources (see all 32):
    (articles sorted by number of sources associating them with YKT6)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. The human SNARE protein Ykt6 mediates its own palmitoylation at C- terminal cysteine residues. (PubMed id 15479160)1, 2, 3, 9 Veit M. (Biochem. J. 2004)
    2. Localization and activity of the SNARE Ykt6 determined by its regulatory domain and palmitoylation. (PubMed id 15044687)1, 2, 9 Fukasawa M.... Rothman J.E. (Proc. Natl. Acad. Sci. U.S.A. 2004)
    3. Participation of the syntaxin 5/Ykt6/GS28/GS15 SNARE complex in transport from the early/recycling endosome to the trans-Golgi network. (PubMed id 15215310)1, 2, 9 Tai G.... Hong W. (Mol. Biol. Cell 2004)
    4. Longins and their longin domains: regulated SNAREs and multifunctional SNARE regulators. (PubMed id 15544955)1, 3 Rossi V....Filippini F. (Trends Biochem. Sci. 2004)
    5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    6. Ykt6p, a prenylated SNARE essential for endoplasmic reticulum-Golgi transport. (PubMed id 9211930)1, 2 McNew J.A.... Soellner T.H. (J. Biol. Chem. 1997)
    7. GS15 forms a SNARE complex with syntaxin 5, GS28, and Ykt6 and is implicated in traffic in the early cisternae of the Golgi apparatus. (PubMed id 12388752)1, 9 Xu Y....Hong W. (Mol. Biol. Cell 2002)
    8. Interlaboratory reproducibility of large-scale human protein-complex analysis by standardized AP-MS. (PubMed id 23455922)1 Varjosalo M....Superti-Furga G. (Nat. Methods 2013)
    9. Bcl2-associated athanogene 3 interactome analysis reveals a new role in modulating proteasome activity. (PubMed id 23824909)1 Chen Y....Ge F. (amp 2013)
    10. A census of human soluble protein complexes. (PubMed id 22939629)1 Havugimana P.C....Emili A. (Cell 2012)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 10652 HGNC: 16959 AceView: YKT6 Ensembl:ENSG00000106636 euGenes: HUgn10652
    ECgene: YKT6 Kegg: 10652 H-InvDB: YKT6

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for YKT6 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for YKT6 gene:
    Search GeneIP for patents involving YKT6

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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