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Aliases for YJEFN3 Gene

Aliases for YJEFN3 Gene

  • YjeF N-Terminal Domain Containing 3 2 3 5
  • HYjeF_N3 3 4
  • YjeF_N3 3 4
  • YjeF N-Terminal Domain-Containing Protein 3 3
  • Apolipoprotein A1 Binding Protein 3
  • HYjeF_N3-19p13.11 3

External Ids for YJEFN3 Gene

Previous GeneCards Identifiers for YJEFN3 Gene

  • GC19P019501
  • GC19P019627
  • GC19P019201
  • GC19P019639

Summaries for YJEFN3 Gene

GeneCards Summary for YJEFN3 Gene

YJEFN3 (YjeF N-Terminal Domain Containing 3) is a Protein Coding gene. An important paralog of this gene is NAXE.

UniProtKB/Swiss-Prot for YJEFN3 Gene

  • May play a role in spermiogenesis and oogenesis.

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for YJEFN3 Gene

Genomics for YJEFN3 Gene

Regulatory Elements for YJEFN3 Gene

Enhancers for YJEFN3 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH19F019484 1.7 FANTOM5 Ensembl ENCODE 5 -40.9 -40888 6.3 HDGF PKNOX1 WRNIP1 ARID4B SIN3A YY1 FOS JUNB REST TBX21 GATAD2A YJEFN3 TM6SF2 RFXANK GMIP PBX4 MAU2 GC19M019490 PIR48619
GH19F019443 1.6 FANTOM5 Ensembl ENCODE 4.9 -80.1 -80135 10.1 HDGF PKNOX1 WRNIP1 ZNF143 ZNF263 REST TBX21 ZNF623 SMARCA4 NBN NDUFA13 GATAD2A GMIP MAU2 YJEFN3 LINC00663 RFXANK BORCS8 GC19P019436 PIR48619
GH19F019402 1.5 FANTOM5 ENCODE 4.9 -123.4 -123427 5.3 PKNOX1 MLX CREB3L1 ZFP64 ARID4B SIN3A DMAP1 YY1 CBX5 ZNF143 NDUFA13 GATAD2A TM6SF2 ENSG00000269191 YJEFN3 GMIP HOMER3 RFXANK ENSG00000267234 GC19P019435
GH19F019374 1.4 Ensembl ENCODE 5.2 -151.9 -151909 4.5 PKNOX1 ARNT ZFP64 ARID4B SIN3A FEZF1 YY1 ZNF766 ZNF207 FOS ENSG00000268030 ZNF90 UPF1 ENSG00000267481 ENSG00000268938 ZNF253 ZNF506 ZNF14 GATAD2A ELL
GH19F019531 1.3 Ensembl ENCODE 5.5 +3.8 3761 1.3 ATF1 PKNOX1 CREB3L1 WRNIP1 SIN3A ZNF2 ZNF48 GLIS2 ZNF143 ZNF207 NDUFA13 GATAD2A ZNF506 ZNF14 YJEFN3 GC19M019535
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around YJEFN3 on UCSC Golden Path with GeneCards custom track

Genomic Location for YJEFN3 Gene

Chromosome:
19
Start:
19,528,861 bp from pter
End:
19,537,584 bp from pter
Size:
8,724 bases
Orientation:
Plus strand

Genomic View for YJEFN3 Gene

Genes around YJEFN3 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
YJEFN3 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for YJEFN3 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for YJEFN3 Gene

Proteins for YJEFN3 Gene

  • Protein details for YJEFN3 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    A6XGL0-YJEN3_HUMAN
    Recommended name:
    YjeF N-terminal domain-containing protein 3
    Protein Accession:
    A6XGL0
    Secondary Accessions:
    • A6XGK9
    • Q4G1C0

    Protein attributes for YJEFN3 Gene

    Size:
    299 amino acids
    Molecular mass:
    32585 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=BC020948; Type=Frameshift; Positions=200; Evidence={ECO:0000305};

    Alternative splice isoforms for YJEFN3 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for YJEFN3 Gene

Post-translational modifications for YJEFN3 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for YJEFN3 Gene

Domains & Families for YJEFN3 Gene

Protein Domains for YJEFN3 Gene

Suggested Antigen Peptide Sequences for YJEFN3 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

A6XGL0

UniProtKB/Swiss-Prot:

YJEN3_HUMAN :
  • Contains 1 YjeF N-terminal domain.
Domain:
  • Contains 1 YjeF N-terminal domain.
genes like me logo Genes that share domains with YJEFN3: view

No data available for Gene Families for YJEFN3 Gene

Function for YJEFN3 Gene

Molecular function for YJEFN3 Gene

UniProtKB/Swiss-Prot Function:
May play a role in spermiogenesis and oogenesis.

Gene Ontology (GO) - Molecular Function for YJEFN3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0052856 NOT NADHX epimerase activity IBA --
GO:0052857 NOT NADPHX epimerase activity IBA --
genes like me logo Genes that share ontologies with YJEFN3: view
genes like me logo Genes that share phenotypes with YJEFN3: view

Animal Model Products

Inhibitory RNA Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for YJEFN3 Gene

Localization for YJEFN3 Gene

Gene Ontology (GO) - Cellular Components for YJEFN3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005739 NOT mitochondrion IBA --
genes like me logo Genes that share ontologies with YJEFN3: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Subcellular locations from COMPARTMENTS for YJEFN3 Gene

Pathways & Interactions for YJEFN3 Gene

SuperPathways for YJEFN3 Gene

No Data Available

Interacting Proteins for YJEFN3 Gene

Gene Ontology (GO) - Biological Process for YJEFN3 Gene

None

No data available for Pathways by source and SIGNOR curated interactions for YJEFN3 Gene

Transcripts for YJEFN3 Gene

Unigene Clusters for YJEFN3 Gene

YjeF N-terminal domain containing 3:
Representative Sequences:

Inhibitory RNA Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for YJEFN3 Gene

No ASD Table

Relevant External Links for YJEFN3 Gene

GeneLoc Exon Structure for
YJEFN3
ECgene alternative splicing isoforms for
YJEFN3

Expression for YJEFN3 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for YJEFN3 Gene

mRNA differential expression in normal tissues according to GTEx for YJEFN3 Gene

This gene is overexpressed in Brain - Putamen (basal ganglia) (x7.6), Brain - Nucleus accumbens (basal ganglia) (x5.6), Brain - Caudate (basal ganglia) (x5.4), and Brain - Hippocampus (x4.2).

Protein differential expression in normal tissues from HIPED for YJEFN3 Gene

This gene is overexpressed in Pancreatic juice (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for YJEFN3 Gene



Protein tissue co-expression partners for YJEFN3 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of YJEFN3 Gene:

YJEFN3

SOURCE GeneReport for Unigene cluster for YJEFN3 Gene:

Hs.729508

mRNA Expression by UniProt/SwissProt for YJEFN3 Gene:

A6XGL0-YJEN3_HUMAN
Tissue specificity: Expressed in theca cells in ovary and in Leydig cells in testis (at protein level). Also expressed in brain and mammary gland.
genes like me logo Genes that share expression patterns with YJEFN3: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery for YJEFN3 Gene

Orthologs for YJEFN3 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for YJEFN3 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia YJEFN3 34 35
  • 99.44 (n)
dog
(Canis familiaris)
Mammalia YJEFN3 34 35
  • 90.63 (n)
cow
(Bos Taurus)
Mammalia YJEFN3 34 35
  • 88.89 (n)
mouse
(Mus musculus)
Mammalia Yjefn3 35
  • 85 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Yjefn3 34
  • 81.74 (n)
oppossum
(Monodelphis domestica)
Mammalia YJEFN3 35
  • 70 (a)
OneToOne
chicken
(Gallus gallus)
Aves LOC100857831 34
  • 74.87 (n)
YJEFN3 35
  • 69 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia YJEFN3 35
  • 66 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia yjefn3 34
  • 62.13 (n)
zebrafish
(Danio rerio)
Actinopterygii yjefn3 34 35
  • 62.41 (n)
fruit fly
(Drosophila melanogaster)
Insecta CG2974 35
  • 39 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea Y18D10A.3 35
  • 26 (a)
OneToMany
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes -- 35
  • 35 (a)
OneToMany
Species where no ortholog for YJEFN3 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for YJEFN3 Gene

ENSEMBL:
Gene Tree for YJEFN3 (if available)
TreeFam:
Gene Tree for YJEFN3 (if available)

Paralogs for YJEFN3 Gene

Paralogs for YJEFN3 Gene

(2) SIMAP similar genes for YJEFN3 Gene using alignment to 3 proteins:

genes like me logo Genes that share paralogs with YJEFN3: view

Variants for YJEFN3 Gene

Sequence variations from dbSNP and Humsavar for YJEFN3 Gene

SNP ID Clin Chr 19 pos Sequence Context AA Info Type
rs10422819 -- 19,532,219(+) TGTTC(A/C)GTGGC intron-variant, utr-variant-5-prime
rs10426732 -- 19,529,245(+) AGCTG(C/T)GTTGC intron-variant, upstream-variant-2KB, reference, missense
rs1054930 -- 19,537,537(+) CCGCG(C/G)CCACA upstream-variant-2KB, utr-variant-3-prime
rs10820 -- 19,527,333(-) TGCCT(C/G/T)TAACA upstream-variant-2KB, reference, missense
rs111375911 -- 19,528,008(+) ACAGG(C/T)GGGGG upstream-variant-2KB, reference, missense

Structural Variations from Database of Genomic Variants (DGV) for YJEFN3 Gene

Variant ID Type Subtype PubMed ID
nsv509723 CNV insertion 20534489
nsv952426 CNV deletion 24416366

Variation tolerance for YJEFN3 Gene

Residual Variation Intolerance Score: 77.7% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.35; 26.70% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for YJEFN3 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
YJEFN3

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for YJEFN3 Gene

Disorders for YJEFN3 Gene

Relevant External Links for YJEFN3

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
YJEFN3

No disorders were found for YJEFN3 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for YJEFN3 Gene

Publications for YJEFN3 Gene

  1. ApoA-I-binding protein (AI-BP) and its homologues hYjeF_N2 and hYjeF_N3 comprise the YjeF_N domain protein family in humans with a role in spermiogenesis and oogenesis. (PMID: 17533573) Rudolph C. … Schmitz G. (Horm. Metab. Res. 2007) 2 3 4 64
  2. The DNA sequence and biology of human chromosome 19. (PMID: 15057824) Grimwood J. … Lucas S.M. (Nature 2004) 3 4 64
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4 64
  4. Genome-wide association analysis identifies 13 new risk loci for schizophrenia. (PMID: 23974872) Ripke S. … Sullivan P.F. (Nat. Genet. 2013) 3 64
  5. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 64

Products for YJEFN3 Gene

Sources for YJEFN3 Gene

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