YJEFN3 Gene
protein-coding GIFtS: 36
GCID: GC19P019627
|
|
YjeF N-terminal domain containing 3
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Aliases
for YJEFN3 gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| YjeF N-Terminal Domain Containing 31 2 | | Apolipoprotein A1 Binding Protein2 | | HYjeF_N3-19p13.111 | | YjeF_N33 | | HYjeF_N31 | | YjeF N-Terminal Domain-Containing Protein 32 | | FLJ449681 | | YjeF_N33 |
Export aliases for YJEFN3 gene to outside databasesPrevious GC identifers: GC19P019501 GC19P019201 |
Summaries
for YJEFN3 gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
UniProtKB/Swiss-Prot: YJEN3_HUMAN, A6XGL0Function: May play a role in spermiogenesis and oogenesis
|
Genomic Views
for YJEFN3 gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000019.9 NC_018930.1 NT_011295.11
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the YJEFN3 gene promoter:
ER-alpha CUTL1 PPAR-gamma1 E2F CP2 E2F-1 STAT3 PPAR-gamma2 ATF6
Other transcription factors
Search SABiosciences Chromatin IP Primers for YJEFN3
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat YJEFN3 |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 19p13.11 Ensembl cytogenetic band: 19p13.11 HGNC cytogenetic band: 19p13.11YJEFN3 Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 19 GeneLoc Exon Structure GeneLoc location for GC19P019627: view genomic region
(about GC identifiers)
Start:
|
19,627,036 bp from pter |
End:
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19,648,393 bp from pter |
Size:
|
21,358 bases |
Orientation:
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plus strand |
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Proteins
for YJEFN3 gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: YJEN3_HUMAN, A6XGL0 (See
protein sequence)Recommended Name: YjeF N-terminal domain-containing protein 3 Size: 299 amino acids; 32585 Da
Sequence caution: Sequence=BC020948; Type=Frameshift; Positions=200;
Secondary accessions: A6XGK9 Q4G1C0Alternative splicing: 2 isoforms: A6XGL0-1 A6XGL0-2 (No experimental confirmation available)Explore the universe of human proteins at neXtProt for YJEFN3: NX_A6XGL0
Post-translational modifications:
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_A6XGL0
YJEFN3 Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins (2 alternative transcripts):
NP_001177257.1 NP_940939.2
ENSEMBL proteins: ENSP00000426964 ENSP00000398520 ENSP00000451799
Human Recombinant Protein Products:
YJEFN3 Antibody Products:
Assay Products for YJEFN3: |
Protein
Domains /
Families
for YJEFN3 gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
YJEFN3 for domains About GeneDecksing
1 InterPro domain/family:Graphical View of Domain Structure for InterPro Entry A6XGL0ProtoNet protein and cluster: A6XGL0 UniProtKB/Swiss-Prot: YJEN3_HUMAN, A6XGL0Similarity: Contains 1 YjeF N-terminal domain |
Function
for YJEFN3 gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Function Summary:
UniProtKB/Swiss-Prot: YJEN3_HUMAN, A6XGL0Function: May play a role in spermiogenesis and oogenesis
Clone
Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for YJEFN3 (see all 2)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for YJEFN3 (see all 2)
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Synthesis Service for YJEFN3 | |  | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat YJEFN3 |
|
Pathways & Interactions
for YJEFN3 gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Interactions:
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for YJEFN3
|
Drugs & Compounds
for YJEFN3 gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
 Browse Tocris compounds for YJEFN3
Search CenterWatch for drugs/clinical trials and news about YJEFN3 / YJEN3
|
Transcripts
for YJEFN3 gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for YJEFN3 gene (2 alternative transcripts): NM_001190328.1 NM_198537.3 Unigene Cluster for YJEFN3: YjeF N-terminal domain containing 3 Hs.729508 [show with all ESTs]Unigene Representative Sequence: AK0574495 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000458210(uc021uqv.1 uc002nmu.2) ENST00000514277 ENST00000436027(uc010ecf.2)
ENST00000510139 ENST00000553705
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for YJEFN3 (see all 2)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for YJEFN3 (see all 2)
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector (see all 2): YJEFN3 (NM_198537) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for YJEFN3 | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat YJEFN3 |
Additional cDNA sequence: AK057449.1 AK094976.1 BC020948.1 BC093948.1 BC112285.1 DQ778079.1 DQ778080.1 4 DOTS entries: DT.75157373 DT.442679 DT.100653454 DT.95353856 24/469 AceView cDNA sequences (see all 469): F33589 CD671540 BU727190 BC009189 CD107235 CD671541 BM665656 AI056888 BM850820 AK094976 BQ026764 AI357370 BM668365 BE908146 BU957352 BQ228787 F30016 CB128799 CF130548 CB159147 BE389629 BM790018 F30223 CD678943
GeneLoc Exon Structure
|
Expression
for YJEFN3 gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| YJEFN3 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: CTAGTGCCGT
About this image
See YJEFN3 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for YJEFN3
SOURCE GeneReport for Unigene cluster: Hs.729508
UniProtKB/Swiss-Prot: YJEN3_HUMAN, A6XGL0Tissue specificity: Expressed in theca cells in ovary and in Leydig cells in testis (at protein level). Also expressedin brain and mammary gland
SABiosciences Custom PCR Arrays for YJEFN3
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for YJEFN3
Browse OriGene validated miRNA SYBR primer pairs
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse, rat YJEFN3 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat YJEFN3 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat YJEFN3 |
Orthologs
for YJEFN3 gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of eukaryotes.
Orthologs for YJEFN3 gene from 7/24 species (see all 24) About this table
| Organism |
Taxonomic
classification |
Gene |
Description |
Human
Similarity |
Orthology
Type |
Details |
chicken
(Gallus gallus) |
Aves |
LOC1008578311 |
yjeF N-terminal domain-containing protein 3-like |
74.74(n)
73.71(a) |
|
100857831 XM_003643399.1 XP_003643447.1 |
lizard
(Anolis carolinensis) |
Reptilia |
YJEFN36 |
-- |
67(a) |
1 → many |
GL344325.1(24830-28585) |
zebrafish
(Danio rerio) |
Actinopterygii |
yjefn31 |
YjeF N-terminal domain containing 3 |
61.11(n)
60.16(a) |
|
557840 NM_001044843.1 NP_001038308.1 |
fruit fly
(Drosophila melanogaster) |
Insecta |
CG29746 |
-- |
41(a) |
1 → many |
X(9978947-9980204) |
worm
(Caenorhabditis elegans) |
Secernentea |
Y18D10A.36 |
NAD(P)H-hydrate epimerase |
26(a) |
1 → many |
I(12810159-12815631) |
thale cress
(Arabidopsis thaliana) |
eudicotyledons |
PPOX6 |
pyridoxin (pyrodoxamine) 5'-phosphate oxidase |
17(a) |
1 → many |
5(20329187-20333155) |
rice
(Oryza sativa) |
Liliopsida |
-- |
pyridoxamine 5'-phosphate oxidase family protein, ... |
18(a) |
1 → many |
10(11996425-12002475) |
ENSEMBL Gene Tree for YJEFN3 (if available)
TreeFam Gene Tree for YJEFN3 (if available) |
Paralogs
for YJEFN3 gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| Paralogs for YJEFN3 gene
- APOA1BP2
2 SIMAP similar genes for YJEFN3 using alignment to 3 protein entries: YJEN3_HUMAN (see all proteins):NDUFA13 APOA1BP
YJEFN3 for paralogs About GeneDecksing
|
Genomic Variants
for YJEFN3 gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 19 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for YJEFN3 (19627036 - 19648393 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV) variations for YJEFN3: -- | SABiosciences Cancer Mutation PCR Assays |
|
Disorders
/ Diseases
for YJEFN3 gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
YJEFN3 for disorders About GeneDecksing
1  disease for YJEFN3: About MalaCardsmalaria
Export disorders for YJEFN3 gene to outside databases
|
Publications
for YJEFN3 gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for YJEFN3 gene integrated from 9 sources:
(articles sorted by number of sources associating them with YJEFN3) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- ApoA-I-binding protein (AI-BP) and its homologues hYjeF_N2 and hYjeF_N3 comprise the YjeF_N domain protein family in humans with a role in spermiogenesis and oogenesis. (PubMed id 17533573)1, 2, 3 Rudolph C.... Schmitz G. (2007)
- The DNA sequence and biology of human chromosome 19. (PubMed id 15057824)1, 2 Grimwood J.... Lucas S.M. (2004)
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
- Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1 Ota T.... Sugano S. (2004)
- Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (2002)
- Hepatitis C virus core protein interacts with 14-3-3 protein and activates the kinase Raf-1. (PubMed id )2 Aoki H.... Hino O. (2000)
|
External Searches for YJEFN3 gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
|
Genome Databases showing YJEFN3 gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing YJEFN3 gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing YJEFN3 gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
| Name | Description |
| PharmGKB entry for YJEFN3 | Pharmacogenomics, SNPs, Pathways |
|
| | |
About This Section
| Patent Information for YJEFN3 gene:
Search GeneIP for patents involving YJEFN3
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for YJEFN3 gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
About This Section
|
 | |
 | |
 |
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| | | QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat YJEFN3 | | | Search QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing YJEFN3 | | | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat YJEFN3 | | | QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat YJEFN3 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat YJEFN3 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat YJEFN3 |
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 | | | YJEFN3 Proteins, Antibodies, CLIAs, and ELISAs |
| | | |  |  |  | | | | ThermoFisher Antibodies for YJEFN3 |
| | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat YJEFN3 |
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