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Aliases for YJEFN3 Gene

Aliases for YJEFN3 Gene

  • YjeF N-Terminal Domain Containing 3 2 3 5
  • HYjeF_N3 3 4
  • YjeF_N3 3 4
  • YjeF N-Terminal Domain-Containing Protein 3 3
  • Apolipoprotein A1 Binding Protein 3
  • HYjeF_N3-19p13.11 3

External Ids for YJEFN3 Gene

Previous GeneCards Identifiers for YJEFN3 Gene

  • GC19P019501
  • GC19P019627
  • GC19P019201
  • GC19P019639

Summaries for YJEFN3 Gene

GeneCards Summary for YJEFN3 Gene

YJEFN3 (YjeF N-Terminal Domain Containing 3) is a Protein Coding gene. An important paralog of this gene is NAXE.

UniProtKB/Swiss-Prot for YJEFN3 Gene

  • May play a role in spermiogenesis and oogenesis.

Additional gene information for YJEFN3 Gene

No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for YJEFN3 Gene

Genomics for YJEFN3 Gene

Regulatory Elements for YJEFN3 Gene


Enhancers around YJEFN3 on UCSC Golden Path with GeneCards custom track

Genomic Location for YJEFN3 Gene

Chromosome:
19
Start:
19,528,861 bp from pter
End:
19,537,584 bp from pter
Size:
8,724 bases
Orientation:
Plus strand

Genomic View for YJEFN3 Gene

Genes around YJEFN3 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
YJEFN3 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for YJEFN3 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for YJEFN3 Gene

Proteins for YJEFN3 Gene

  • Protein details for YJEFN3 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    A6XGL0-YJEN3_HUMAN
    Recommended name:
    YjeF N-terminal domain-containing protein 3
    Protein Accession:
    A6XGL0
    Secondary Accessions:
    • A6XGK9
    • Q4G1C0

    Protein attributes for YJEFN3 Gene

    Size:
    299 amino acids
    Molecular mass:
    32585 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=BC020948; Type=Frameshift; Positions=200; Evidence={ECO:0000305};

    Alternative splice isoforms for YJEFN3 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for YJEFN3 Gene

Post-translational modifications for YJEFN3 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for YJEFN3 Gene

Domains & Families for YJEFN3 Gene

Gene Families for YJEFN3 Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Protein Domains for YJEFN3 Gene

Suggested Antigen Peptide Sequences for YJEFN3 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with YJEFN3: view

No data available for UniProtKB/Swiss-Prot for YJEFN3 Gene

Function for YJEFN3 Gene

Molecular function for YJEFN3 Gene

UniProtKB/Swiss-Prot Function:
May play a role in spermiogenesis and oogenesis.

Phenotypes From GWAS Catalog for YJEFN3 Gene

Gene Ontology (GO) - Molecular Function for YJEFN3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0052856 NOT NADHX epimerase activity IBA --
GO:0052857 NOT NADPHX epimerase activity IBA --
genes like me logo Genes that share ontologies with YJEFN3: view
genes like me logo Genes that share phenotypes with YJEFN3: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

Clone Products

  • Applied Biological Materials Clones for YJEFN3
  • Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for YJEFN3 Gene

Localization for YJEFN3 Gene

Subcellular locations from the

Human Protein Atlas (HPA)

Gene Ontology (GO) - Cellular Components for YJEFN3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005739 NOT mitochondrion IBA --
genes like me logo Genes that share ontologies with YJEFN3: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Subcellular locations from COMPARTMENTS for YJEFN3 Gene

Pathways & Interactions for YJEFN3 Gene

SuperPathways for YJEFN3 Gene

No Data Available

Interacting Proteins for YJEFN3 Gene

Gene Ontology (GO) - Biological Process for YJEFN3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006734 NOT NADH metabolic process IBA --
GO:0006739 NOT NADP metabolic process IBA --
genes like me logo Genes that share ontologies with YJEFN3: view

No data available for Pathways by source and SIGNOR curated interactions for YJEFN3 Gene

Drugs & Compounds for YJEFN3 Gene

No Compound Related Data Available

Transcripts for YJEFN3 Gene

Unigene Clusters for YJEFN3 Gene

YjeF N-terminal domain containing 3:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

  • Applied Biological Materials Clones for YJEFN3
  • Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more

Alternative Splicing Database (ASD) splice patterns (SP) for YJEFN3 Gene

No ASD Table

Relevant External Links for YJEFN3 Gene

GeneLoc Exon Structure for
YJEFN3
ECgene alternative splicing isoforms for
YJEFN3

Expression for YJEFN3 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for YJEFN3 Gene

mRNA differential expression in normal tissues according to GTEx for YJEFN3 Gene

This gene is overexpressed in Brain - Putamen (basal ganglia) (x7.6), Brain - Nucleus accumbens (basal ganglia) (x5.6), Brain - Caudate (basal ganglia) (x5.4), and Brain - Hippocampus (x4.2).

Protein differential expression in normal tissues from HIPED for YJEFN3 Gene

This gene is overexpressed in Pancreatic juice (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for YJEFN3 Gene



Protein tissue co-expression partners for YJEFN3 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of YJEFN3 Gene:

YJEFN3

SOURCE GeneReport for Unigene cluster for YJEFN3 Gene:

Hs.729508

mRNA Expression by UniProt/SwissProt for YJEFN3 Gene:

A6XGL0-YJEN3_HUMAN
Tissue specificity: Expressed in theca cells in ovary and in Leydig cells in testis (at protein level). Also expressed in brain and mammary gland.
genes like me logo Genes that share expression patterns with YJEFN3: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for YJEFN3 Gene

Orthologs for YJEFN3 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for YJEFN3 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia YJEFN3 33 34
  • 99.44 (n)
dog
(Canis familiaris)
Mammalia YJEFN3 33 34
  • 90.63 (n)
cow
(Bos Taurus)
Mammalia YJEFN3 33 34
  • 88.89 (n)
mouse
(Mus musculus)
Mammalia Yjefn3 34
  • 85 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Yjefn3 33
  • 81.74 (n)
oppossum
(Monodelphis domestica)
Mammalia YJEFN3 34
  • 70 (a)
OneToOne
chicken
(Gallus gallus)
Aves LOC100857831 33
  • 74.87 (n)
YJEFN3 34
  • 69 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia YJEFN3 34
  • 66 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia yjefn3 33
  • 62.13 (n)
zebrafish
(Danio rerio)
Actinopterygii yjefn3 33 34
  • 62.41 (n)
fruit fly
(Drosophila melanogaster)
Insecta CG2974 34
  • 39 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea Y18D10A.3 34
  • 26 (a)
OneToMany
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes -- 34
  • 35 (a)
OneToMany
Species where no ortholog for YJEFN3 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for YJEFN3 Gene

ENSEMBL:
Gene Tree for YJEFN3 (if available)
TreeFam:
Gene Tree for YJEFN3 (if available)

Paralogs for YJEFN3 Gene

Paralogs for YJEFN3 Gene

(2) SIMAP similar genes for YJEFN3 Gene using alignment to 3 proteins:

genes like me logo Genes that share paralogs with YJEFN3: view

Variants for YJEFN3 Gene

Sequence variations from dbSNP and Humsavar for YJEFN3 Gene

SNP ID Clin Chr 19 pos Sequence Context AA Info Type
rs1000439111 -- 19,532,223(+) CCGTG(C/G)CTCCC intron-variant, utr-variant-5-prime
rs1000471739 -- 19,531,958(+) TGGTC(G/T)GGAAC intron-variant, utr-variant-5-prime
rs1001066110 -- 19,534,856(+) CCAGC(A/G)GGGAA intron-variant
rs1001155495 -- 19,527,760(+) CGTGC(C/T)CGACT upstream-variant-2KB, reference, missense
rs1001434526 -- 19,537,832(+) TGGGC(A/G)ACATA downstream-variant-500B, upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for YJEFN3 Gene

Variant ID Type Subtype PubMed ID
nsv509723 CNV insertion 20534489
nsv952426 CNV deletion 24416366

Variation tolerance for YJEFN3 Gene

Residual Variation Intolerance Score: 77.7% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.35; 26.70% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for YJEFN3 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
YJEFN3

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for YJEFN3 Gene

Disorders for YJEFN3 Gene

Relevant External Links for YJEFN3

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
YJEFN3

No disorders were found for YJEFN3 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for YJEFN3 Gene

Publications for YJEFN3 Gene

  1. ApoA-I-binding protein (AI-BP) and its homologues hYjeF_N2 and hYjeF_N3 comprise the YjeF_N domain protein family in humans with a role in spermiogenesis and oogenesis. (PMID: 17533573) Rudolph C … Schmitz G (Hormone and metabolic research = Hormon- und Stoffwechselforschung = Hormones et metabolisme 2007) 2 3 4 60
  2. The DNA sequence and biology of human chromosome 19. (PMID: 15057824) Grimwood J … Lucas SM (Nature 2004) 3 4 60
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 60
  4. Genome-wide association analysis identifies 13 new risk loci for schizophrenia. (PMID: 23974872) Ripke S … Sullivan PF (Nature genetics 2013) 3 60
  5. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 60

Products for YJEFN3 Gene

Sources for YJEFN3 Gene

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