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Aliases for YIPF7 Gene

Aliases for YIPF7 Gene

  • Yip1 Domain Family Member 7 2 3 5
  • Five-Pass Transmembrane Protein Localizing In The Golgi Apparatus And The Endoplasmic Reticulum 9 3 4
  • YIP1 Family Member 7 3 4
  • FinGER9 3 4
  • Yip1 Domain Family, Member 7 2
  • Protein YIPF7 3
  • YIP1B 4

External Ids for YIPF7 Gene

Previous GeneCards Identifiers for YIPF7 Gene

  • GC04M044466
  • GC04M044325
  • GC04M043946

Summaries for YIPF7 Gene

GeneCards Summary for YIPF7 Gene

YIPF7 (Yip1 Domain Family Member 7) is a Protein Coding gene. Diseases associated with YIPF7 include De Quervain Disease. An important paralog of this gene is YIPF5.

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for YIPF7 Gene

Genomics for YIPF7 Gene

Regulatory Elements for YIPF7 Gene

Enhancers for YIPF7 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH04F044677 0.4 ENCODE 0.8 -0.5 -473 3.0 PKNOX1 CREB3L1 WRNIP1 ARID4B SIN3A DMAP1 YY1 ZNF207 ZHX2 JUNB GUF1 GNPDA2 YIPF7 GC04M044690
- Elite enhancer/Elite enhancer-gene association Download Table
Download GeneHancer data dump

Enhancers around YIPF7 on UCSC Golden Path with GeneCards custom track

Promoters for YIPF7 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00001240336 -644 3201 PKNOX1 ATF1 CREB3L1 ARID4B SIN3A GLI4 DMAP1 ZNF48 ETS1 YY1

Genomic Location for YIPF7 Gene

Chromosome:
4
Start:
44,621,970 bp from pter
End:
44,678,556 bp from pter
Size:
56,587 bases
Orientation:
Minus strand

Genomic View for YIPF7 Gene

Genes around YIPF7 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
YIPF7 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for YIPF7 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for YIPF7 Gene

Proteins for YIPF7 Gene

  • Protein details for YIPF7 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8N8F6-YIPF7_HUMAN
    Recommended name:
    Protein YIPF7
    Protein Accession:
    Q8N8F6
    Secondary Accessions:
    • Q3SY21
    • Q3SY22

    Protein attributes for YIPF7 Gene

    Size:
    280 amino acids
    Molecular mass:
    30632 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for YIPF7 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for YIPF7 Gene

Post-translational modifications for YIPF7 Gene

  • Glycosylation at Asn 39
  • Modification sites at PhosphoSitePlus

Other Protein References for YIPF7 Gene

No data available for DME Specific Peptides for YIPF7 Gene

Domains & Families for YIPF7 Gene

Gene Families for YIPF7 Gene

Protein Domains for YIPF7 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for YIPF7 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q8N8F6

UniProtKB/Swiss-Prot:

YIPF7_HUMAN :
  • Belongs to the YIP1 family.
Family:
  • Belongs to the YIP1 family.
genes like me logo Genes that share domains with YIPF7: view

Function for YIPF7 Gene

genes like me logo Genes that share phenotypes with YIPF7: view

Animal Model Products

Inhibitory RNA Products

Flow Cytometry Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for YIPF7 Gene

Localization for YIPF7 Gene

Subcellular locations from UniProtKB/Swiss-Prot for YIPF7 Gene

Endoplasmic reticulum membrane; Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for YIPF7 Gene COMPARTMENTS Subcellular localization image for YIPF7 gene
Compartment Confidence
endoplasmic reticulum 3
plasma membrane 3
golgi apparatus 1

Gene Ontology (GO) - Cellular Components for YIPF7 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005789 endoplasmic reticulum membrane IEA --
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with YIPF7: view

Pathways & Interactions for YIPF7 Gene

SuperPathways for YIPF7 Gene

No Data Available

Interacting Proteins for YIPF7 Gene

Gene Ontology (GO) - Biological Process for YIPF7 Gene

None

No data available for Pathways by source and SIGNOR curated interactions for YIPF7 Gene

Transcripts for YIPF7 Gene

mRNA/cDNA for YIPF7 Gene

(2) REFSEQ mRNAs :
(3) Additional mRNA sequences :
(6) Selected AceView cDNA sequences:
(5) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for YIPF7 Gene

Yip1 domain family, member 7:
Representative Sequences:

Inhibitory RNA Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for YIPF7 Gene

No ASD Table

Relevant External Links for YIPF7 Gene

GeneLoc Exon Structure for
YIPF7
ECgene alternative splicing isoforms for
YIPF7

Expression for YIPF7 Gene

mRNA expression in normal human tissues for YIPF7 Gene

mRNA differential expression in normal tissues according to GTEx for YIPF7 Gene

This gene is overexpressed in Muscle - Skeletal (x35.3).

NURSA nuclear receptor signaling pathways regulating expression of YIPF7 Gene:

YIPF7

SOURCE GeneReport for Unigene cluster for YIPF7 Gene:

Hs.596000
genes like me logo Genes that share expression patterns with YIPF7: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners and mRNA Expression by UniProt/SwissProt for YIPF7 Gene

Orthologs for YIPF7 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for YIPF7 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia YIPF7 34 35
  • 98.81 (n)
cow
(Bos Taurus)
Mammalia YIPF7 34 35
  • 88.37 (n)
dog
(Canis familiaris)
Mammalia YIPF7 34 35
  • 84.97 (n)
mouse
(Mus musculus)
Mammalia Yipf7 34 16 35
  • 83.6 (n)
rat
(Rattus norvegicus)
Mammalia Yipf7 34
  • 83.46 (n)
oppossum
(Monodelphis domestica)
Mammalia YIPF7 35
  • 80 (a)
OneToOne
chicken
(Gallus gallus)
Aves YIPF7 34 35
  • 71.76 (n)
lizard
(Anolis carolinensis)
Reptilia YIPF7 35
  • 62 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia yipf7 34
  • 66.53 (n)
zebrafish
(Danio rerio)
Actinopterygii zgc:123321 34
  • 62.62 (n)
YIPF7 35
  • 59 (a)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta CG12404 35
  • 41 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea F32D8.14 35
  • 37 (a)
OneToMany
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes YIP1 35
  • 33 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea CSA.977 35
  • 48 (a)
OneToMany
Species where no ortholog for YIPF7 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for YIPF7 Gene

ENSEMBL:
Gene Tree for YIPF7 (if available)
TreeFam:
Gene Tree for YIPF7 (if available)

Paralogs for YIPF7 Gene

Paralogs for YIPF7 Gene

(1) SIMAP similar genes for YIPF7 Gene using alignment to 3 proteins:

genes like me logo Genes that share paralogs with YIPF7: view

Variants for YIPF7 Gene

Sequence variations from dbSNP and Humsavar for YIPF7 Gene

SNP ID Clin Chr 04 pos Sequence Context AA Info Type
rs10015229 -- 44,647,158(+) CAGGG(A/T)AGGCC intron-variant
rs10018722 -- 44,642,411(+) AAATT(G/T)AAATT intron-variant
rs1020128 -- 44,630,825(+) TCACC(A/G)CTTCT intron-variant
rs10446545 -- 44,620,016(+) AAAAT(A/G)TTGCA utr-variant-3-prime
rs10446546 -- 44,620,084(+) AGCAA(C/T)AAAAC utr-variant-3-prime

Structural Variations from Database of Genomic Variants (DGV) for YIPF7 Gene

Variant ID Type Subtype PubMed ID
nsv1013488 CNV loss 25217958
nsv477500 CNV novel sequence insertion 20440878
nsv509893 OTHER sequence alteration 20534489

Variation tolerance for YIPF7 Gene

Residual Variation Intolerance Score: 67.6% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 4.50; 64.50% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for YIPF7 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
YIPF7

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for YIPF7 Gene

Disorders for YIPF7 Gene

MalaCards: The human disease database

(1) MalaCards diseases for YIPF7 Gene - From: DISEASES

Disorder Aliases PubMed IDs
de quervain disease
  • radial styloid tenosynovitis
- elite association - COSMIC cancer census association via MalaCards
Search YIPF7 in MalaCards View complete list of genes associated with diseases

Relevant External Links for YIPF7

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
YIPF7
genes like me logo Genes that share disorders with YIPF7: view

No data available for UniProtKB/Swiss-Prot and Genatlas for YIPF7 Gene

Publications for YIPF7 Gene

  1. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4 64
  2. Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. (PMID: 16344560) Kimura K. … Sugano S. (Genome Res. 2006) 3 64
  3. Generation and annotation of the DNA sequences of human chromosomes 2 and 4. (PMID: 15815621) Hillier L.W. … Wilson R.K. (Nature 2005) 4 64
  4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 4 64
  5. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg R.L. … Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002) 3 64

Products for YIPF7 Gene

Sources for YIPF7 Gene

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