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YIPF7 Gene

protein-coding GIFtS: 38

GC04M044325

Yip1 domain family, member 7
Symbol approved by the HUGO Gene Nomenclature Committee (HGNC) database

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc , and/or ⁷Ensembl, ⁸miRBase)
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Aliases
FINGER9 ^³
FLJ39576 ^¹, ²
FinGER9 ^¹, ²
MGC120164 ^²
YIP1B ^³

Descriptions
Five-pass transmembrane protein localizing in the Golgi apparatus and the endoplasmic reticulum 9 ^³
YIP1 family member 7 ^³
Yip1 domain family, member 7 ^²

External Ids
HGNC: 26825¹
Entrez Gene: 285525²
UniProtKB: Q8N8F6³
Ensembl: ENSG00000177752⁷

Search outside databases for aliases for YIPF7 gene

Previous GC identifer: GC04M044466

(According to Entrez Gene, Wikipedia's Gene Wiki,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 36),
and/or miRBase,
Genomic Views according to UCSC and Ensembl, Transcription factor binding sites according to SABiosciences)
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Genomic View:

UCSC Golden Path with GeneCards custom track

Transcription factor binding sites upstream to the YIPF7 gene

Entrez Gene cytogenetic band: 4p13 Ensembl cytogenetic band: 4p13 HGNC cytogenetic band: 4p13

YIPF7 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)

GeneLoc gene densities for chromosome 4 GeneLoc Exon Structure

GeneLoc location for GC04M044325: (about GC identifiers)

Start:	44,319,111 bp from pter
End:	44,348,415 bp from pter
Size:	29,305 bases
Orientation:	minus strand

RefSeq DNA sequence:

NC_000004.10 NT_006238.10

(According to ¹UniProtKB, and/or Ensembl, Phosphorylation sites according to ²Phosphosite, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Enzo Life Sciences, Abnova, OriGene and/or, Abcam,
Biochemical Assays by Invitrogen, Millipore, R&D Systems, Cell Signaling Technology, and/or Enzo Life Sciences, Ontologies according to Gene Ontology Consortium 01 Apr 2009 and Entrez Gene, Antibodies by Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Cell Signaling Technology, Abcam, Abnova, and/or Novus Biologicals)
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UniProtKB/Swiss-Prot: YIPF7_HUMAN, Q8N8F6 (See protein sequence)

Recommended Name: Protein YIPF7

Size: 280 amino acids; 30632 Da

Subcellular location: Endoplasmic reticulum membrane; Multi-pass membrane protein (By similarity)

Caution: It is uncertain whether Met-1 or Met-25 is the initiator

Secondary accessions: Q3SY21 Q3SY22

Alternative splicing: 4 isoforms: Q8N8F6-1 Q8N8F6-2 Q8N8F6-3 Q8N8F6-4

REFSEQ proteins: NP_872398.2

ENSEMBL proteins:

ENSP00000332772

Human Recombinant Proteins

	Browse Drug Discovery Central at Invitrogen for human recombinant proteins
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	Browse Abnova for Human Recombinant Proteins

Browse Origene for full length recombinant human proteins expressed in human HEK293 cells

4 Gene Ontology (GO) cellular component terms (links to tree view):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005783	endoplasmic reticulum	IEA	--
GO:0005789	endoplasmic reticulum membrane	IEA	--
GO:0016020	membrane	IEA	--
GO:0016021	integral to membrane	IEA	--

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Antibodies for YIPF7:

	Browse Antibodies Central at Invitrogen
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	Browse Abnova for Monoclonal and Polyclonal Antibodies
	Search Novus for antibodies for YIPF7

Assays for YIPF7:

	Browse Invitrogen for biochemical assays
	Browse Kits and Assays available from Millipore
	Browse R&D Systems for biochemical assays
	Browse biochemical assays available from Enzo Life Sciences

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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Graphical View of Domain Structure for InterPro Entry Q8N8F6

ProtoNet protein and cluster: Q8N8F6

UniProtKB/Swiss-Prot: YIPF7_HUMAN, Q8N8F6

Similarity: Belongs to the YIP1 family

(According to MGI Jun 06 2009, UniProtKB, IUBMB,and/or Genatlas,
shRNA from OriGene, Sigma-Aldrich, RNAi from Sigma-Aldrich,
RNAi Products, Clones, and Q-PCR Products from Invitrogen, Millipore, OriGene, and/or Abnova, siRNAs from Applied Biosystems, SYBR primers from OriGene, Cell-based Assays from Millipore, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
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Inhib. RNA:		Invitrogen RNAi Products for gene knock-down (YIPF7)
		Browse for Gene Knock-down Tools from Millipore
		Browse Abnova for Chimera RNAi Products

OriGene 29mer shRNA kit in GFP-retroviral vector: NM_182592

Applied Biosystems Silencer® siRNAs for YIPF7

Sigma-Aldrich siRNA for YIPF7

Sigma-Aldrich shRNA for YIPF7

Explore Sigma-Aldrich super-pooled esiRNAs

Clones:		Browse Clone Ranger at Invitrogen for clones
		Browse Clones for the Expression of Recombinant Proteins Available from Millipore

OriGene GFP tagged cDNA clone in CMV expression vector: NM_182592
Myc/DDK tagged cDNA clone in CMV expression vector: NM_182592
untagged cDNA clones in CMV expression vector (see all 2): NM_182592

Primers:

Browse Quantitative PCR Central at Invitrogen for Q-PCR LUX™ Primers

OriGene genome-wide validated SYBR primer pairs: NM_182592

(Pathways according to Invitrogen (maps by GeneGo), Millipore, Cell Signaling Technology, Sigma-Aldrich, KEGG and/or UniProtKB,
Sets of similar genes according to GeneDecks, Proteins Network according to SABiosciences, Interactions according to ¹UniProtKB, ²MINT, and/or ³STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
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(Chemical Compounds according to UniProtKB, Enzo Life Sciences, Sigma-Aldrich, Tocris Bioscience, and/or Novoseek and Drugs according to Enzo Life Sciences and/or PharmGKB)
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Browse drugs & compounds from Enzo Life Sciences

Browse Small Molecules at Sigma-Aldrich

Browse Tocris compounds for YIPF7

(GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 219 Homo sapiens; Jun 2 2009) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView,
non coding RNAs according to RNAdb,
ESTs according to GeneTide,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from Invitrogen, Millipore, and/or Abnova,
siRNAs from Applied Biosystems, Sigma-Aldrich,
shRNA from Sigma-Aldrich, OriGene,
Tagged/untagged cDNA clones from OriGene,
Expression Assays from Applied Biosystems)
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Inhib. RNA:		Invitrogen RNAi Products for gene knock-down (YIPF7)
		Browse for Gene Knock-down Tools from Millipore
		Browse Abnova for Chimera RNAi Products

OriGene 29mer shRNA kit in GFP-retroviral vector: NM_182592

Sigma-Aldrich siRNA for YIPF7

Sigma-Aldrich shRNA for YIPF7

Explore Sigma-Aldrich super-pooled esiRNAs

Applied Biosystems Silencer® siRNAs:

NM_182592

REFSEQ mRNAs for YIPF7 gene:

NM_182592.2

Applied Biosystems TaqMan ® Gene Expression Assays:

NM_182592

              OriGene GFP tagged cDNA clone in CMV expression vector: NM_182592
                                 Myc/DDK tagged cDNA clone in CMV expression vector: NM_182592
                                 untagged cDNA clones in CMV expression vector (see all 2): NM_182592

Additional cDNA sequence:

AK096895.1 BC103995.1 BC103996.1

2 DOTS entries:

DT.99930440 DT.65287862

6 AceView cDNA sequences:

AI672261 AI480122 BX279752 NM_182592 AK096895 R88629

highest scoring ESTs for YIPF7:

AK096895 NM_182592 BC103995 BC103996 DA895313 DA899652 AI672261 DA111259 DB331007 F23269

Unigene Cluster for YIPF7:

Yip1 domain family, member 7

Hs.596000 [show with all ESTs]

Unigene Representative Sequence: AK096895

GeneLoc Exon Structure

1 Ensembl transcript including schematic representation:

ENST00000332990

(Experimental results according to ¹GeneNote and GNF BioGPS,
probe sets-to-genes annotations according to ²GeneAnnot , ³GeneTide , Sets of similar genes according to GeneDecks, Electronic Northern calculations according to data from UniGene (Build 219 Homo sapiens), SAGE tags according to CGAP, plus additional links to SOURCE, and/or GNF BioGPS, and/or EXPOLDB, and/or UniProtKB,
Expression Assays from Applied Biosystems )
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YIPF7 expression in normal and diseased human tissues

Applied Biosystems TaqMan ® Gene Expression Assays for YIPF7

¹ / ² / ³

1 probe-set matching YIPF7 gene

	Affymetrix probe-set	Array	# genes	Sensitivity	Specificity	Correlation	Length	Gb_Accession	Consensus	Uniqueness	Score	Rank
	Affymetrix probe-set	Array	GeneAnnot data			GeneNote data		GeneTide data
	69652_at²^{, 3}	U95-E	1	0.94	1.00	1.00	1.00	AI672261	0.20	1.00	0.72	1

GeneDecks YIPF7 for binary patterns associated with the probe-sets selected above

About GeneDecksing

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Data from

(Publications) and GNF BioGPS
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About these images

CGAP SAGE TAG: --

SOURCE GeneReport for Unigene cluster: Hs.596000

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD and/or ⁵MGI Jun 06 2009, with possible further links to Flybase and/or WormBase, Gene Trees according to Ensembl)
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Orthologs for YIPF7 gene from 5/6 species (see all 6 )

Organism	Gene	Locus	Description	Human Similarity	NCBI accessions
dog (Canis familiaris)	YIPF7¹	--	Yip1 domain family, member 7	84.97(n) 80(a)	475137 XM_532367.2 XP_532367.1
cow (Bos taurus)	YIPF7¹	--	Yip1 domain family, member 7	88.24(n) 88.24(a)	522186 XM_600461.3 XP_600461.3
rat (Rattus norvegicus)	Yipf7¹	--	Yip1 domain family, member 7	83.46(n) 82.81(a)	364147 XM_344236.2 XP_344237.1
mouse (Mus musculus)	Yipf7^{1, 5}	5⁵	Yip1 domain family, member 7^{1, 5}	83.6(n)¹ 81.5(a)¹	75581¹ NM_023784.4¹ NP_076273.1¹ AF217188⁵ AK009405⁵ (see all 6)
chicken (Gallus gallus)	YIPF7¹	--	Yip1 domain family, member 7	71.76(n) 69.8(a)	422774 XM_420728.1 XP_420728.1

About this table Species with no ortholog for YIPF7

ENSEMBL Gene Tree for YIPF7

(Paralogs according to ¹HomoloGene
and ²Ensembl, Pseudogenes according to ³Pseudogene.org)
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Paralogs for YIPF7 gene

YIPF5²

(According to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, and UniProtKB, Linkage Disequilibrium by HapMap, Genotyping Reagents from Applied Biosystems)
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10/186 NCBI SNPs in YIPF7 are shown (see all 186 )
(Click for Applied Biosystems TaqMan ® Genotyping Assay) (see all 93)

AB	SNP ID	Valid	Chr 4 pos	Sequence	Recs	AA Chg	Type	More	Recs	Pop	Total sample	More
AB	Genomic Data				Transcription Data				Allele Frequencies
				--	--	--		--	--			--
	rs2348353^1,2	A,C,F,H,O	44346787(+)	`ATAGGC/TATTAG`	1	A/T	mis¹ ese³		17	NS EU EA WA NA	1164
	rs990356^1,2	A,C,F,H	44318913(+)	`AATACA/CTCTAT`	1	--	ng5¹		14	MN EU EA WA NA	2878
	rs4235133^1,2	A,C,F,H	44350101(+)	`AAAATG/ATGATG`	1	--	ng3¹		8	EU EA WA	832
	rs1388311^1,2	C,F,H,O	44348759(+)	`TAGAAG/AATCTC`	1	--	ng3¹		7	NA EU EA WA	558
	rs3213898^1,2	C,F,H	44318934(+)	`AGGGTT/CGATCA`	1	--	ng5¹		13	EA EU WA	2752
	rs4632694^1,2	H	44350118(+)	`TATTAG/TTCACA`	1	--	ng3¹		4	EU EA WA	418
	rs6819533^1,2	H	44318766(+)	`ACATAC/TCCCTG`	1	--	ng5¹		4	EU EA WA	408
	rs3213899^1,2	H	44319109(+)	`CATATC/TACCAA`	1	--	ng5¹		4	EU EA WA	416
	rs1371242^1,2	A,C,F,H,O	44325701(+)	`TTTCAT/CAGTAG`	1	--	int¹ ese³		7	NA EU EA WA	560
	rs1898864^1,2	A,C,F,H,O	44325305(+)	`CCTGGT/CTTATC`	1	--	int¹		11	NA EU EA WA	980

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HapMap Linkage Disequilibrium images for YIPF7 (up to first 250kb)

(in which this Gene is Involved, According to OMIM, UniProtKB, PharmGKB, Genatlas, GeneTests, Blood group antigen gene mutations by BGMUT, HGMD, GAD, HuGE Navigator, BCGD, and/or TGDB.)
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(Possibly Related Articles in Doctor's Guide)
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(in PubMed. Associations of this gene to articles via ¹Novoseek, ²HGNC, ³Entrez Gene, ⁴UniProtKB/Swiss-Prot, ⁵UniProtKB/TrEMBL, ⁶GAD, and/or ⁷PharmGKB)
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6 PubMed articles for YIPF7 gene:

Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)^{3, 4} Ota T....Sugano S. (2004)
Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. (PubMed id 16344560)³ Kimura K.... Sugano S. (2006)
Generation and annotation of the DNA sequences of human chromosomes 2 and 4. (PubMed id 15815621)⁴ Hillier L.W....Wilson R.K. (2005)
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)⁴ Gerhard D.S....Malek J. (2004)
Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)³ Strausberg R.L....Marra M.A. (2002)
Toward a complete human genome sequence. (PubMed id 9847074)³ (1998)

(in PubMed, OMIM, and NCBI Bookshelf)
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		AND	OR
Aliases
Free Text

Query String		PubMed OMIM NCBI Bookshelf
	(Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, and/or H-InvDB)
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Entrez Gene: 285525	HGNC: 26825	AceView: FLJ39576	Ensembl:ENSG00000177752	euGenes: HUgn285525
ECgene: YIPF7	H-InvDB: YIPF7

(According to HUGE)
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(According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
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Licensable Technologies for YIPF7
(Available from WIS Yeda, Salk, Tufts)

About This Section

(Reagents available from Applied Biosystems, Antibodies and assays by Cell Signaling Technology, Abcam, Novus Biologicals,
Sigma-Aldrich, R&D Systems, Millipore, Abnova, and/or Invitrogen, Clones available from OriGene,and/or Invitrogen, Drugs and/or compounds by Sigma-Aldrich,
Enzo Life Sciences, and/or Tocris Bioscience)
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Products for YIPF7:

TaqMan ® Gene Expression Assays

TaqMan ® Genotyping Assays

Free SNP selection tool

Invitrogen iPath Pathways	Invitrogen BLOCK-iT™ RNAi
Invitrogen Antibodies	Invitrogen Assays
Invitrogen Clones	Invitrogen Q-PCR Products
Invitrogen Human Recombinant Kinases	Invitrogen Custom Antibody and Peptide Service
Invitrogen Proteins / Assays / Screening Services	Search Invitrogen catalog for YIPF7-related products

	Millipore Custom Antibody & Bulk Services
	Millipore Preclinical / Clinical Development Services
	Millipore Immunoassay Services
	Millipore Target Screening & Profiling Services

	Predesigned and custom siRNAs for YIPF7		Browse antibodies at Sigma-Aldrich
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	Recombinant & Natural Proteins

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Search Novus for antibodies for YIPF7

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YIPF7 Gene

protein-coding GIFtS: 38

Aliases &
Descriptions
for YIPF7

Summaries
for YIPF7

Genomic Location
for YIPF7

Proteins
for YIPF7

Protein Domains/
Families
for YIPF7

Gene Function
for YIPF7

Pathways & Interactions
for YIPF7

Drugs & Compounds
for YIPF7

Transcripts
for YIPF7

Expression
for YIPF7

Orthologs
for YIPF7

Paralogs
for YIPF7

SNPs/Variants
for YIPF7

Disorders & Mutations
for YIPF7

Medical News
for YIPF7

Publications
for YIPF7

Search for YIPF7

Genome Databases showing YIPF7

Other Databases showing YIPF7

Specialized Databases showing YIPF7

Licensable Technologies
for YIPF7

Services
for YIPF7

Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

YIPF7 Gene

protein-coding GIFtS: 38

Aliases & Descriptionsfor YIPF7

Summariesfor YIPF7

Genomic Locationfor YIPF7

Proteinsfor YIPF7

Protein Domains/Familiesfor YIPF7

Gene Functionfor YIPF7

Pathways & Interactionsfor YIPF7

Drugs & Compoundsfor YIPF7

Transcriptsfor YIPF7

Expression for YIPF7

Orthologsfor YIPF7

Paralogsfor YIPF7

SNPs/Variantsfor YIPF7

Disorders & Mutationsfor YIPF7

Medical Newsfor YIPF7

Publicationsfor YIPF7

Search for YIPF7

Genome Databases showing YIPF7

Other Databases showing YIPF7

Specialized Databases showing YIPF7

Licensable Technologiesfor YIPF7

Servicesfor YIPF7

Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

Aliases &
Descriptions
for YIPF7

Summaries
for YIPF7

Genomic Location
for YIPF7

Proteins
for YIPF7

Protein Domains/
Families
for YIPF7

Gene Function
for YIPF7

Pathways & Interactions
for YIPF7

Drugs & Compounds
for YIPF7

Transcripts
for YIPF7

Expression
for YIPF7

Orthologs
for YIPF7

Paralogs
for YIPF7

SNPs/Variants
for YIPF7

Disorders & Mutations
for YIPF7

Medical News
for YIPF7

Publications
for YIPF7

Licensable Technologies
for YIPF7

Services
for YIPF7