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YIPF7 Gene

protein-coding GIFtS: 39
GCID: GC04M044624

Yip1 Domain Family, Member 7

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disease database

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc, ⁷Ensembl, ⁸DME, ⁹miRBase, ¹⁰fRNAdb, ¹²H-InvDB, ¹³NCBI, ¹⁴NONCODE, and/or ¹⁵RNAdb)
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This gene clusters with an RNA gene
Subcategory (RNA class): antisense

Quality score for the ORGUL clustered with this gene is 3

Aliases
Yip1 Domain Family, Member 7¹ ²		Protein YIPF7²
Five-Pass Transmembrane Protein Localizing In The Golgi Apparatus And The Endoplasmic Reticulum 9² ³		FINGER9³
YIP1 Family Member 7² ³		YIP1B³
FinGER9²

External Ids:	HGNC: 26825¹	Entrez Gene: 285525²	Ensembl: ENSG00000177752⁷	UniProtKB: Q8N8F6³

ORGUL members:

Export aliases for YIPF7 gene to outside databases

Previous GC identifers: GC04M044466 GC04M044325 GC04M043946

(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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GeneCards Summary for YIPF7 Gene:

YIPF7 (Yip1 domain family, member 7) is a protein-coding gene. An important paralog of this gene is YIPF5.

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:

NC_000004.11 NT_006238.12 NC_018915.2

Regulatory elements:

Regulatory transcription factor binding sites in the YIPF7 gene promoter:
GR Pbx1a AML1a AP-1 GR-beta POU3F2 (N-Oct-5a) POU3F2 (N-Oct-5b) LCR-F1 POU3F2 GR-alpha
Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: YIPF7 promoter sequence

Search Chromatin IP Primers for YIPF7

Epigenetics:

DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat YIPF7

Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 4p12 Ensembl cytogenetic band: 4p12 HGNC cytogenetic band: 4p13

YIPF7 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
YIPF7 gene location

GeneLoc information about chromosome 4 GeneLoc Exon Structure

GeneLoc location for GC04M044624: view genomic region (about GC identifiers)

Start:	44,624,086 bp from pter	End:	44,680,573 bp from pter
Size:	56,488 bases	Orientation:	minus strand

(According to ¹UniProtKB, HORDE, ²neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., eBioscience, and/or antibodies-online,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., eBioscience, and/or antibodies-online, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, Cloud-Clone Corp, antibodies-online, and/or others.)
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UniProtKB/Swiss-Prot: YIPF7_HUMAN, Q8N8F6 (See protein sequence)

Recommended Name: Protein YIPF7

Size: 280 amino acids; 30632 Da

Caution: It is uncertain whether Met-1 or Met-25 is the initiator

Secondary accessions: Q3SY21 Q3SY22

Alternative splicing: 4 isoforms: Q8N8F6-1 Q8N8F6-2 Q8N8F6-3 Q8N8F6-4 (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for YIPF7: NX_Q8N8F6

Post-translational modifications:

Glycosylation² at Asn39

REFSEQ proteins: NP_872398.2

ENSEMBL proteins:

ENSP00000412696 ENSP00000477355 ENSP00000332772

YIPF7 Human Recombinant Protein Products:

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(According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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HGNC Gene Families:

YIPF: Yip1 domain family

1 InterPro protein domain:

IPR006977 Yip1

Graphical View of Domain Structure for InterPro Entry Q8N8F6

ProtoNet protein and cluster: Q8N8F6

UniProtKB/Swiss-Prot: YIPF7_HUMAN, Q8N8F6

Similarity: Belongs to the YIP1 family

Find genes that share domains with YIPF7 About GenesLikeMe

(According to ¹UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or ²DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, genOway,
transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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Phenotypes:
1 GenomeRNAi human phenotype for YIPF7:

Decreased POU5F1-GFP protein e

Animal Models:

genOway: Develop your customized and physiologically relevant rodent model for YIPF7

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In Situ Assay
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(According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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Subcellular locations from UniProtKB/Swiss-Prot

YIPF7_HUMAN, Q8N8F6: Endoplasmic reticulum membrane; Multi-pass membrane protein (By similarity)

Subcellular locations from COMPARTMENTS:

Compartment	Confidence
endoplasmic reticulum	5
plasma membrane	3

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Gene Ontology (GO): 3 cellular component terms: About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005789	endoplasmic reticulum membrane	IEA	--
GO:0016020	membrane	--	--
GO:0016021	integral component of membrane	IEA	--

Find genes that share ontologies with YIPF7 About GenesLikeMe

(SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to ¹UniProtKB, ²MINT, ³I2D, and/or ⁴STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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Custom Pathway & Disease-focused RT² Profiler PCR Arrays for YIPF7
Interactions:

Search GeneGlobe Interaction Network for YIPF7

STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

Selected Interacting proteins for YIPF7 (ENSP00000412696⁴) via UniProtKB, MINT, STRING, and/or I2D (see all 68)

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
RABAC1	ENSP00000222008⁴	STRING: ENSP00000222008
IER3IP1	ENSP00000256433⁴	STRING: ENSP00000256433
SEC13	ENSP00000312122⁴	STRING: ENSP00000312122
YIPF6	ENSP00000417573⁴	STRING: ENSP00000417573
RAB1A	ENSP00000387286⁴	STRING: ENSP00000387286

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(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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Browse Small Molecules at EMD Millipore

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Browse Tocris compounds for YIPF7

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
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REFSEQ mRNAs for YIPF7 gene:

NM_182592.2

Unigene Cluster for YIPF7:

Yip1 domain family, member 7

Hs.596000 [show with all ESTs]

Unigene Representative Sequence: AK096895

5 Ensembl transcripts including schematic representations, and UCSC links where relevant:

ENST00000415895 ENST00000510035(uc010ify.2) ENST00000502794 ENST00000508947

ENST00000332990(uc021xnx.1)

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Additional mRNA sequence:

AK096895.1 BC103995.1 BC103996.1

2 DOTS entries:

DT.99930440 DT.65287862

6 AceView cDNA sequences:

AI672261 AI480122 BX279752 NM_182592 AK096895 R88629

GeneLoc Exon Structure

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE ¹MOPED, ²PaxDb, and ³MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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YIPF7 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS <intensity>^2/3
CGAP TAG: --

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YIPF7 Protein expression data from MOPED¹, PaxDb² and MaxQB³:

--

SOURCE GeneReport for Unigene cluster: Hs.596000

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In Situ
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(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD , ⁵MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or ⁶Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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This gene was present in the common ancestor of animals and fungi.

Orthologs for YIPF7 gene from Selected species (see all 14) About this table

Organism	Taxonomic classification	Gene	Description	Human Similarity	Orthology Type	Details
mouse (Mus musculus)	Mammalia	Yipf7^{1 , 5}	Yip1 domain family, member 7^{1, 5}	83.6(n)¹ 81.5(a)¹		5 (37.13 cM)⁵ 75581¹ NM_023784.5¹ NP_076273.1¹ 69516675⁵
chicken (Gallus gallus)	Aves	YIPF7¹	Yip1 domain family, member 7	71.76(n) 69.8(a)		422774 NM_001277822.1 NP_001264751.1
lizard (Anolis carolinensis)	Reptilia	YIPF7⁶	Yip1 domain family, member 7	62(a)	1 ↔ 1	5(102140270-102197447)
tropical clawed frog (Xenopus tropicalis)	Amphibia	yipf7¹	Yip1 domain family, member 7	66.53(n) 64.61(a)		100492489 XM_002933464.2 XP_002933510.2
zebrafish (Danio rerio)	Actinopterygii	zgc:123321¹	zgc:123321	62.62(n) 59.92(a)		559912 NM_001037233.1 NP_001032310.1
fruit fly (Drosophila melanogaster)	Insecta	CG12404⁶	--	41(a)	1 → many	2L(12993748-13000631)
worm (Caenorhabditis elegans)	Secernentea	F32D8.14⁶	Protein F32D8.14, isoform b (F32D8.14) mRNA, compl...	37(a)	1 → many	V(10893649-10894767) WBGene00009336
baker's yeast (Saccharomyces cerevisiae)	Saccharomycetes	YIP1⁶	Integral membrane protein required for the biogene...	33(a)	1 → many	VII(842845-843591) YGR172C

ENSEMBL Gene Tree for YIPF7 (if available)
TreeFam Gene Tree for YIPF7 (if available)

(Paralogs according to ¹HomoloGene,
²Ensembl, and ³SIMAP, Pseudogenes according to ⁴Pseudogene.org Build 68)
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Paralogs for YIPF7 gene

YIPF5²

1 SIMAP similar gene for YIPF7 using alignment to 3 protein entries: YIPF7_HUMAN (see all proteins):

YIPF5

Find genes that share paralogs with YIPF7 About GenesLikeMe

(SNPs/Variants according to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, ⁴UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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SNP ID	Valid	Clinical significance	Chr 4 pos	Sequence	#	AA Chg	Type	More	#	Allele freq	Pop	Total sample	More
Genomic Data					Transcription Related Data				Allele Frequencies
				--	--	--		--	--
rs6844310^1,2	C,F	--	44623876(+)	`TAAGAA/CGGAAG`	1	--	ds500¹		1		WA	118
rs190024190^1,2		--	44623902(+)	`GTGGTA/GAGTCA`	1	--	ds500¹		0	--	--	--	--
rs35962907^1,2	C	--	44623946(+)	`TAAAGT/-AAGTG`	1	--	ds500¹		1		CSA	2
rs68087334^1,2	C	--	44623947(+)	`AAAGA-/TAGTGA`	1	--	ds500¹		0	--	--	--	--
rs181100007^1,2		--	44623957(+)	`AATTGA/TAAGGC`	1	--	ds500¹		0	--	--	--	--
rs6819533^1,2	C,H	--	44624009(+)	`ACATAC/TCCCTG`	1	--	ds500¹		4		NS EA	408
rs74862882^1,2	C,F	--	44624076(+)	`TGTCAT/CGAAAG`	1	--	ds500¹		1		NA	120
rs79379876^1,2	C,F	--	44624101(+)	`TACTAG/CAGATT`	1	--	ds500¹		2		WA	120
rs990356^1,2	C,F,A,H	--	44624156(+)	`AATACA/CTCTAT`	1	--	ds500¹		36		MN EA NA NS WA CSA	4823
rs3213898^1,2	C,F,H	--	44624177(+)	`AGGGTT/CGATCA`	1	--	ds500¹		13		EA NS NA	2574

HapMap Linkage Disequilibrium report for YIPF7 (44624086 - 44680573 bp)

Structural Variations
Database of Genomic Variants (DGV) 1 variation for YIPF7: About this table

Variant ID	Type	Subtype	PubMed ID
nsv509893	CNV	Loss	20534489

Site Specific Mutation Identification with PCR Assays

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(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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(in PubMed. Associations of this gene to articles via ¹Entrez Gene, ²UniProtKB/Swiss-Prot, ³HGNC, ⁴GAD, ⁵PharmGKB, ⁶HMDB, ⁷DrugBank, ⁸UniProtKB/TrEMBL, ⁹ Novoseek, and/or ¹⁰fRNAdb)
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PubMed articles for YIPF7 gene integrated from 10 sources:
(articles sorted by number of sources associating them with YIPF7)

Utopia: connect your pdf to the dynamic
world of online information

Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)^{1, 2} Ota T.... Sugano S. (Nat. Genet. 2004)
Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. (PubMed id 16344560)¹ Kimura K.... Sugano S. (Genome Res. 2006)
Generation and annotation of the DNA sequences of human chromosomes 2 and 4. (PubMed id 15815621)² Hillier L.W.... Wilson R.K. (Nature 2005)
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)² Gerhard D.S.... Malek J. (Genome Res. 2004)
Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)¹ Strausberg R.L....Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002)
Toward a complete human genome sequence. (PubMed id 9847074)¹ Sulston J.E. and Waterston R. (Genome Res. 1998)

(in PubMed, OMIM, and NCBI Bookshelf)
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		AND	OR
Aliases
Free Text

Query String		PubMed OMIM NCBI Bookshelf
	(Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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Entrez Gene: 285525	HGNC: 26825	AceView: FLJ39576	Ensembl:ENSG00000177752	euGenes: HUgn285525
ECgene: YIPF7	H-InvDB: YIPF7

(According to HUGE)
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(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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Name	Description
PharmGKB entry for YIPF7	Pharmacogenomics, SNPs, Pathways

Intellectual Property for YIPF7 gene
(Patent information from GeneIP, Licensable technologies from WIS Yeda, Salk, Tufts, IP news from LifeMap Sciences, Inc.)

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Patent Information for YIPF7 gene:
Search GeneIP for patents involving YIPF7

GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search

(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, eBioscience, antibodies-online, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
Advanced Cell Diagnostics, Animal models from genOway)
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GeneCards Homepage - Last full update: 7 May 2014 - Incrementals: 9 May 2014 , 2 Jun 2014 , 26 Jun 2014 , 30 Jun 2014 , 21 Aug 2014 , 8 Sep 2014 , 2 Nov 2014 , 8 Jan 2015

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Hot genes Disease genes YIPF7 gene at Home site.

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YIPF7 Gene

Yip1 Domain Family, Member 7

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YIPF7 Gene

Yip1 Domain Family, Member 7

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