YIPF6 Gene
protein-coding GIFtS: 47
GCID: GC0XP067718
|
|
Yip1 domain family, member 6
| |
Aliases
for YIPF6 gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| Yip1 Domain Family, Member 61 2 | | FinGER61 2 | | YIP1 Family Member 62 3 | | MGC214161 | | Protein YIPF62 |
Export aliases for YIPF6 gene to outside databasesPrevious GC identifers: GC0XP067502 GC0XP067634 GC0XP061546 |
Summaries
for YIPF6 gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
Gene Wiki entry for YIPF6
|
Genomic Views
for YIPF6 gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000023.10 NC_018934.1 NT_011669.17
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the YIPF6 gene promoter:
TBP Evi-1 Arnt MEF-2A Sox9 c-Jun aMEF-2 RSRFC4 ATF6 ATF
Other transcription factors
Search SABiosciences Chromatin IP Primers for YIPF6
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat YIPF6 |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: Xq12 Ensembl cytogenetic band: Xq12 HGNC cytogenetic band: Xq13.1YIPF6 Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome X GeneLoc Exon Structure GeneLoc location for GC0XP067718: view genomic region
(about GC identifiers)
Start:
|
67,718,165 bp from pter |
End:
|
67,757,127 bp from pter |
Size:
|
38,963 bases |
Orientation:
|
plus strand |
|
Proteins
for YIPF6 gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: YIPF6_HUMAN, Q96EC8 (See
protein sequence)Recommended Name: Protein YIPF6 Size: 236 amino acids; 26256 Da
Subcellular location: Membrane; Multi-pass membrane protein (Potential)
Secondary accessions: Q5JP08Explore the universe of human proteins at neXtProt for YIPF6: NX_Q96EC8
Post-translational modifications:
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_Q96EC8
YIPF6 Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins (2 alternative transcripts):
NP_001182143.1 NP_776195.2
ENSEMBL proteins: ENSP00000417573 ENSP00000401799 ENSP00000363751 Reactome Protein details: Q96EC8
Human Recombinant Protein Products:
Gene Ontology (GO): 3 cellular component terms (GO ID links to tree view): About this table
YIPF6 for ontologies About GeneDecksing
YIPF6 Antibody Products:
Assay Products for YIPF6: |
Protein
Domains /
Families
for YIPF6 gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
YIPF6 for domains About GeneDecksing
1 InterPro domain/family:Graphical View of Domain Structure for InterPro Entry Q96EC8ProtoNet protein and cluster: Q96EC8 UniProtKB/Swiss-Prot: YIPF6_HUMAN, Q96EC8Similarity: Belongs to the YIP1 family |
Function
for YIPF6 gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Clone
Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for YIPF6 (see all 4)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for YIPF6 (see all 3)
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling 
| |  | GenScript: all cDNA clones in your preferred vector (see all 2): YIPF6 (NM_001195214) | |  | Browse Sino Biological Human cDNA Clones | |  | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for YIPF6 | |  | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat YIPF6 |
In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for YIPF6 |
Animal Models:
6 MGI mutant phenotypes (inferred from 1 allele ) (MGI details for Yipf6):
YIPF6 for phenotypes About GeneDecksing
|
Pathways & Interactions
for YIPF6 gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Unified GeneCards pathways About this table
See pathways by source
| Super-pathway | contained gene-specific pathways |
|---|
| 1 | Clathrin derived vesicle budding | | | 2 | Membrane Trafficking | |
Pathway sources
See GeneCards unified pathways
Show all pathways
4 
Reactome Pathways for YIPF6
YIPF6 for pathways About GeneDecksing
Interactions:
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for YIPF6
STRING Interaction
Network Preview (showing 3 interactants - click image to see more details)
3 Interacting proteins for YIPF6 (Q96EC83 ENSP000004175734) via UniProtKB, MINT, STRING, and/or I2DAbout this table
|
Drugs & Compounds
for YIPF6 gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
 Browse Tocris compounds for YIPF6
Search CenterWatch for drugs/clinical trials and news about YIPF6
|
Transcripts
for YIPF6 gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for YIPF6 gene (2 alternative transcripts): NM_001195214.1 NM_173834.3 Unigene Cluster for YIPF6: Yip1 domain family, member 6 Hs.82719 [show with all ESTs]Unigene Representative Sequence: NM_1738347 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000462683(uc004dwz.3 uc011mph.2) ENST00000451537 ENST00000470730
ENST00000374643 ENST00000462972 ENST00000496576 ENST00000374622
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for YIPF6 (see all 4)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for YIPF6 (see all 3)
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector (see all 2): YIPF6 (NM_001195214) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for YIPF6 | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat YIPF6 |
Additional cDNA sequence: AK024673.1 AK026979.1 AK095555.1 AK292835.1 AK303992.1 AL117461.1 BC012469.1 U79272.1 15 DOTS entries: DT.443024 DT.215833 DT.311510 DT.100789520 DT.121291193 DT.100789541 DT.100036446 DT.100789521 DT.452543 DT.100789518 DT.121291202 DT.121291205 DT.95277966 DT.121291183 DT.121291208 24/288 AceView cDNA sequences (see all 288): AI539451 BM547411 BF793582 BU168281 BG109860 BU737702 AL117461 AI439508 AK024673 CB156714 AI129260 AA349738 BU726870 AI758231 BI791510 AW136627 AI670729 AA782140 BE673403 BQ439305 BM712232 BI222749 AA534344 AI492829
GeneLoc Exon Structure
4 Alternative Splicing Database (ASD) splice patterns (SP) for YIPF6 About this scheme
| ExUns: | 1a | · | 1b | · | 1c | ^ | 2 | ^ | 3a | · | 3b | · | 3c | ^ | 4 | ^ | 5 | ^ | 6a | · | 6b | ^ | 7 |
|---|
|
| SP1: | | | | | - | | | | | | - | | - | | | | | | - | | | | | | |
| SP2: | | | | | - | | | | | | - | | - | | | | | | | | | | | | |
| SP3: | | | | | | | | | | | | | | | | | | | | | | | | | |
| SP4: | | | | | - | | | | | | | | | | | | | | | | | | | |
ECgene alternative splicing isoforms for YIPF6
|
Expression
for YIPF6 gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| YIPF6 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: AACCCAAGAG
About this image
See YIPF6 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for YIPF6
SOURCE GeneReport for Unigene cluster: Hs.82719
SABiosciences Custom PCR Arrays for YIPF6
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for YIPF6
Browse OriGene validated miRNA SYBR primer pairs
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse / rat YIPF6 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat YIPF6 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat YIPF6 | In Situ
Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for YIPF6 |
Orthologs
for YIPF6 gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of eukaryotes.
Orthologs for YIPF6 gene from 8/31 species (see all 31) About this table
| Organism |
Taxonomic
classification |
Gene |
Description |
Human
Similarity |
Orthology
Type |
Details |
mouse
(Mus musculus) |
Mammalia |
Yipf61 , 5 |
Yip1 domain family, member 61, 5 |
77.59(n)1
83.83(a)1 |
|
X (43.19 cM)5
779291 NM_207633.21 NP_997516.11
989363165 |
chicken
(Gallus gallus) |
Aves |
YIPF61 |
Yip1 domain family, member 6 |
73.22(n)
76.92(a) |
|
422161 XM_420160.3 XP_420160.2 |
African clawed frog
(Xenopus laevis) |
Amphibia |
Xl.158002 |
Xenopus laevis transcribed sequence with weak similarity to protein refNP_493177.1 (C.elegans) Yeast YIP1 protein like [Caenorhabditis elegans] less |
73.39(n) |
|
BX844750.1 |
zebrafish
(Danio rerio) |
Actinopterygii |
Dr.123162 |
Transcribed sequence with weak similarity to protein refNP_115688.1 (H.sapiens) hypothetical protein MGC11061 [Homo sapiens] less |
75.84(n) |
|
CK028181.1 |
fruit fly
(Drosophila melanogaster) |
Insecta |
CG36521 |
CG3652 |
55.18(n)
53.4(a) |
|
33643 NM_134984.3 NP_608828.2 |
worm
(Caenorhabditis elegans) |
Secernentea |
W02D9.21 |
Protein W02D9.2 |
52.25(n)
52.97(a) |
|
173123 NM_060776.5 NP_493177.2 |
thale cress
(Arabidopsis thaliana) |
eudicotyledons |
AT4G302601 |
Yip1 integral membrane domain-containing protein |
52.16(n)
43.53(a) |
|
829149 NM_119172.3 NP_567843.1 |
rice
(Oryza sativa) |
Liliopsida |
Os01g08677001 |
hypothetical protein |
46.76(n)
38.86(a) |
|
4325047 NM_001051450.1 NP_001044915.1 |
ENSEMBL Gene Tree for YIPF6 (if available)
TreeFam Gene Tree for YIPF6 (if available) |
Paralogs
for YIPF6 gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| Paralogs for YIPF6 gene
- YIPF42
YIPF6 for paralogs About GeneDecksing
|
Genomic Variants
for YIPF6 gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr X pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for YIPF6 (67718165 - 67757127 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV) variations for YIPF6: -- | SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing YIPF6 |
|
Disorders
/ Diseases
for YIPF6 gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
YIPF6 for disorders About GeneDecksing
2  diseases for YIPF6: About MalaCardscongenital diaphragmatic hernia hernia
1 disease from the University of Copenhagen DISEASES database for YIPF6:Congenital diaphragmatic hernia Export disorders for YIPF6 gene to outside databases
|
Publications
for YIPF6 gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for YIPF6 gene, integrated from 9 sources (see all 12):
(articles sorted by number of sources associating them with YIPF6) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- The DNA sequence of the human X chromosome. (PubMed id 15772651)1, 2 Ross M.T.... Bentley D.R. (2005)
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
- Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1, 3 Strausberg R.L....Marra M.A. (2002)
- Ubiquitin-mediated proteolysis of HuR by heat shock. (PubMed id 19322201)1 Abdelmohsen K....Gorospe M. (2009)
- Toward a confocal subcellular atlas of the human proteome. (PubMed id 18029348)1 Barbe L....Andersson-Svahn H. (2008)
- The LIFEdb database in 2006. (PubMed id 16381901)1 Mehrle A....Wiemann S. (2006)
- Towards a proteome-scale map of the human protein-protein interaction network. (PubMed id 16189514)1 Rual J.F....Vidal M. (2005)
- Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1 Ota T.... Sugano S. (2004)
- From ORFeome to biology: a functional genomics pipeline. (PubMed id 15489336)1 Wiemann S....Poustka A. (2004)
- Transcriptome characterization elucidates signaling networks that control human ES cell growth and differentiation. (PubMed id 15146197)1 Brandenberger R.... Stanton L.W. (2004)
|
External Searches for YIPF6 gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
|
Genome Databases showing YIPF6 gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing YIPF6 gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing YIPF6 gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
| Name | Description |
| PharmGKB entry for YIPF6 | Pharmacogenomics, SNPs, Pathways |
|
| | |
About This Section
| Patent Information for YIPF6 gene:
Search GeneIP for patents involving YIPF6
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for YIPF6 gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
About This Section
|
 | |
 | |
 |
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| |
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| | | QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat YIPF6 | | | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing YIPF6 | | | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat YIPF6 | | | QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat YIPF6 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat YIPF6 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat YIPF6 |
| |
 |  |  |  | |
| | | | Search Tocris compounds for YIPF6 |
| |  |  |  |  | | | | |
 |
 |
 |
 | | | YIPF6 Proteins, Antibodies, CLIAs, and ELISAs |
| | | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for YIPF6 |
|  |  |  | | | | Search ThermoFisher Antibodies for YIPF6 |
| | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat YIPF6 |
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