Free for academic non-profit institutions. Other users need a Commercial license

Aliases for YIPF6 Gene

Aliases for YIPF6 Gene

  • Yip1 Domain Family Member 6 2 3 5
  • YIP1 Family Member 6 3 4
  • Yip1 Domain Family, Member 6 2
  • Protein YIPF6 3
  • FinGER6 3

External Ids for YIPF6 Gene

Previous GeneCards Identifiers for YIPF6 Gene

  • GC0XP067502
  • GC0XP067634
  • GC0XP067718
  • GC0XP061546

Summaries for YIPF6 Gene

GeneCards Summary for YIPF6 Gene

YIPF6 (Yip1 Domain Family Member 6) is a Protein Coding gene. Among its related pathways are Clathrin derived vesicle budding and Vesicle-mediated transport. Gene Ontology (GO) annotations related to this gene include identical protein binding.

UniProtKB/Swiss-Prot for YIPF6 Gene

  • May be required for stable YIPF1 and YIPF2 protein expression.

Gene Wiki entry for YIPF6 Gene

Additional gene information for YIPF6 Gene

No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for YIPF6 Gene

Genomics for YIPF6 Gene

GeneHancer (GH) Regulatory Elements for YIPF6 Gene

Promoters and enhancers for YIPF6 Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH0XI068496 Promoter/Enhancer 2 EPDnew Ensembl ENCODE 555.5 +0.2 180 3.4 PKNOX1 SMAD1 MLX ARID4B NEUROD1 SIN3A DMAP1 ZNF2 YY1 POLR2B YIPF6 SERBP1P1 GC0XP068533 GC0XP068269
GH0XI068646 Promoter/Enhancer 1.7 EPDnew Ensembl ENCODE 11.7 +149.4 149398 1.6 CTCF ZNF449 SIN3A ZIC2 ZNF335 GLIS2 POLR2A ZBTB48 NFYB ZBTB20 STARD8 YIPF6 ACTR3P2
GH0XI068463 Enhancer 1.2 Ensembl ENCODE 13.2 -35.5 -35522 0.4 PKNOX1 ATF1 ARNT ZNF133 FEZF1 GLI4 ZNF2 GTF3C2 ZNF121 ZNF766 YIPF6 LOC100128467 OPHN1 GC0XP068269
GH0XI068462 Enhancer 0.9 ENCODE 13.2 -35.9 -35869 0.2 NFXL1 ZBTB40 GTF3C2 ZNF335 ZNF766 FOS ATF7 RCOR1 CREM ZNF362 YIPF6 LOC100128467 OPHN1 GC0XP068269
GH0XI069284 Enhancer 1 Ensembl ENCODE 9.9 +787.5 787498 1.7 RB1 KLF17 RAD21 GLIS2 EGR1 ZNF143 EGR2 ZNF654 ZBTB11 REST YIPF6 FAM155B PIR50037 GC0XM069229
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around YIPF6 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the YIPF6 gene promoter:

Genomic Locations for YIPF6 Gene

Genomic Locations for YIPF6 Gene
74,008 bases
Plus strand

Genomic View for YIPF6 Gene

Genes around YIPF6 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
YIPF6 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for YIPF6 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for YIPF6 Gene

Proteins for YIPF6 Gene

  • Protein details for YIPF6 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Protein YIPF6
    Protein Accession:
    Secondary Accessions:
    • B4E1U7
    • G5E997
    • Q5JP08

    Protein attributes for YIPF6 Gene

    236 amino acids
    Molecular mass:
    26256 Da
    Quaternary structure:
    • Predominantly interacts with YIPF1 or YIPF2, but may also form a ternary complex with YIPF1 and YIPF2. This interaction may stabilize YIPF1 and YIPF2.

    Alternative splice isoforms for YIPF6 Gene


neXtProt entry for YIPF6 Gene

Post-translational modifications for YIPF6 Gene

  • Glycosylation at posLast=5555 and isoforms=2144

Other Protein References for YIPF6 Gene

No data available for DME Specific Peptides for YIPF6 Gene

Domains & Families for YIPF6 Gene

Gene Families for YIPF6 Gene

Human Protein Atlas (HPA):
  • Predicted membrane proteins

Protein Domains for YIPF6 Gene


Suggested Antigen Peptide Sequences for YIPF6 Gene

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the YIP1 family.
  • Belongs to the YIP1 family.
genes like me logo Genes that share domains with YIPF6: view

Function for YIPF6 Gene

Molecular function for YIPF6 Gene

UniProtKB/Swiss-Prot Function:
May be required for stable YIPF1 and YIPF2 protein expression.

Gene Ontology (GO) - Molecular Function for YIPF6 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 16189514
GO:0042802 identical protein binding IEA --
genes like me logo Genes that share ontologies with YIPF6: view
genes like me logo Genes that share phenotypes with YIPF6: view

Animal Model Products

CRISPR Products

miRNA for YIPF6 Gene

miRTarBase miRNAs that target YIPF6

Inhibitory RNA Products

No data available for Enzyme Numbers (IUBMB) , Phenotypes From GWAS Catalog , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for YIPF6 Gene

Localization for YIPF6 Gene

Subcellular locations from UniProtKB/Swiss-Prot for YIPF6 Gene

Golgi apparatus membrane; Multi-pass membrane protein. Note=Evenly distributed between cis- and trans-Golgi apparatus (PubMed:27999994). Mainly localizes within medial-/trans-Golgi and trans-Golgi network (TGN), while less so within cis-Golgi (PubMed:28286305). {ECO:0000269 PubMed:27999994, ECO:0000269 PubMed:28286305}.

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for YIPF6 gene
Compartment Confidence
golgi apparatus 5
endoplasmic reticulum 4
plasma membrane 2
nucleus 2

Subcellular locations from the

Human Protein Atlas (HPA)

Gene Ontology (GO) - Cellular Components for YIPF6 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000138 Golgi trans cisterna IDA 28286305
GO:0000139 Golgi membrane IEA --
GO:0005783 endoplasmic reticulum IDA --
GO:0005794 Golgi apparatus IEA --
GO:0005797 Golgi medial cisterna IDA 28286305
genes like me logo Genes that share ontologies with YIPF6: view

Pathways & Interactions for YIPF6 Gene

genes like me logo Genes that share pathways with YIPF6: view

Gene Ontology (GO) - Biological Process for YIPF6 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0060576 intestinal epithelial cell development IEA --
genes like me logo Genes that share ontologies with YIPF6: view

No data available for SIGNOR curated interactions for YIPF6 Gene

Drugs & Compounds for YIPF6 Gene

No Compound Related Data Available

Transcripts for YIPF6 Gene

Unigene Clusters for YIPF6 Gene

Yip1 domain family, member 6:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Alternative Splicing Database (ASD) splice patterns (SP) for YIPF6 Gene

ExUns: 1a · 1b · 1c ^ 2 ^ 3a · 3b · 3c ^ 4 ^ 5 ^ 6a · 6b ^ 7
SP1: - - - -
SP2: - - -
SP4: -

Relevant External Links for YIPF6 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for YIPF6 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for YIPF6 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for YIPF6 Gene

This gene is overexpressed in Nasal epithelium (60.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for YIPF6 Gene

NURSA nuclear receptor signaling pathways regulating expression of YIPF6 Gene:


SOURCE GeneReport for Unigene cluster for YIPF6 Gene:


Evidence on tissue expression from TISSUES for YIPF6 Gene

  • Kidney(4.3)
  • Nervous system(3.6)
genes like me logo Genes that share expression patterns with YIPF6: view

Primer Products

No data available for mRNA differential expression in normal tissues , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for YIPF6 Gene

Orthologs for YIPF6 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for YIPF6 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia YIPF6 33 34
  • 99.86 (n)
(Bos Taurus)
Mammalia YIPF6 33 34
  • 92.8 (n)
(Canis familiaris)
Mammalia YIPF6 33 34
  • 91.67 (n)
(Monodelphis domestica)
Mammalia YIPF6 34
  • 79 (a)
(Rattus norvegicus)
Mammalia Yipf6 33
  • 78.16 (n)
(Mus musculus)
Mammalia Yipf6 33 16 34
  • 77.59 (n)
(Ornithorhynchus anatinus)
Mammalia YIPF6 34
  • 48 (a)
(Gallus gallus)
Aves YIPF6 33 34
  • 73.36 (n)
(Anolis carolinensis)
Reptilia YIPF6 34
  • 80 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia yipf6 33
  • 70.16 (n)
Str.8591 33
African clawed frog
(Xenopus laevis)
Amphibia Xl.15800 33
(Danio rerio)
Actinopterygii yipf6 33 34
  • 69.89 (n)
Dr.12316 33
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP008226 33
  • 56.13 (n)
fruit fly
(Drosophila melanogaster)
Insecta CG3652 33 34
  • 55.44 (n)
(Caenorhabditis elegans)
Secernentea W02D9.2 34 33
  • 52.41 (n)
thale cress
(Arabidopsis thaliana)
eudicotyledons AT2G18840 33
  • 50.98 (n)
(Oryza sativa)
Liliopsida Os01g0867700 33
  • 47.01 (n)
fission yeast
(Schizosaccharomyces pombe)
Schizosaccharomycetes SPAC644.13c 33
  • 53.17 (n)
sea squirt
(Ciona savignyi)
Ascidiacea -- 34
  • 53 (a)
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.4967 33
Species where no ortholog for YIPF6 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for YIPF6 Gene

Gene Tree for YIPF6 (if available)
Gene Tree for YIPF6 (if available)

Paralogs for YIPF6 Gene

No data available for Paralogs for YIPF6 Gene

Variants for YIPF6 Gene

Sequence variations from dbSNP and Humsavar for YIPF6 Gene

SNP ID Clin Chr 0X pos Variation AA Info Type
rs1000031093 -- 68,555,580(+) G/A genic_downstream_transcript_variant, intron_variant
rs1000084964 -- 68,569,847(+) T/C genic_downstream_transcript_variant, intron_variant
rs1000088710 -- 68,563,457(+) C/T genic_downstream_transcript_variant, intron_variant
rs1000192586 -- 68,555,166(+) T/A genic_downstream_transcript_variant, intron_variant
rs1000217554 -- 68,546,116(+) T/C genic_downstream_transcript_variant, intron_variant

Structural Variations from Database of Genomic Variants (DGV) for YIPF6 Gene

Variant ID Type Subtype PubMed ID
esv1584074 OTHER inversion 17803354
esv3332626 CNV insertion 20981092

Variation tolerance for YIPF6 Gene

Residual Variation Intolerance Score: 64.9% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.23; 5.15% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for YIPF6 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for YIPF6 Gene

Disorders for YIPF6 Gene

Additional Disease Information for YIPF6

No disorders were found for YIPF6 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for YIPF6 Gene

Publications for YIPF6 Gene

  1. YIPF1, YIPF2, and YIPF6 are medial-/trans-Golgi and trans-Golgi network-localized Yip domain family proteins, which play a role in the Golgi reassembly and glycan synthesis. (PMID: 28286305) Soonthornsit J … Nakamura N (Experimental cell research 2017) 3 4 58
  2. The DNA sequence of the human X chromosome. (PMID: 15772651) Ross MT … Bentley DR (Nature 2005) 3 4 58
  3. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4 58
  4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 58
  5. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg RL … Mammalian Gene Collection Program Team (Proceedings of the National Academy of Sciences of the United States of America 2002) 2 3 58

Products for YIPF6 Gene

Sources for YIPF6 Gene

Loading form....