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YIPF6 Gene

protein-coding GIFtS: 46

GC0XP067634

Yip1 domain family, member 6
Symbol approved by the HUGO Gene Nomenclature Committee (HGNC) database

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc , and/or ⁷Ensembl, ⁸miRBase)
About This Section

Aliases
FinGER6 ^¹, ²
MGC21416 ^¹, ²
OTTHUMP00000023452 ^²

Descriptions
YIP1 family member 6 ^³
Yip1 domain family, member 6 ^²

External Ids
HGNC: 28304¹
Entrez Gene: 286451²
UniProtKB: Q96EC8³
Ensembl: ENSG00000181704⁷

Search outside databases for aliases for YIPF6 gene

Previous GC identifer: GC0XP067502

(According to Entrez Gene, Wikipedia's Gene Wiki,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Gene Wiki entry for YIPF6

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 36),
and/or miRBase,
Genomic Views according to UCSC and Ensembl, Transcription factor binding sites according to SABiosciences)
About This Section

Genomic View:

UCSC Golden Path with GeneCards custom track

Transcription factor binding sites upstream to the YIPF6 gene

Entrez Gene cytogenetic band: Xq12 Ensembl cytogenetic band: Xq12 HGNC cytogenetic band: Xq13.1

YIPF6 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)

GeneLoc gene densities for chromosome X GeneLoc Exon Structure

GeneLoc location for GC0XP067634: (about GC identifiers)

Start:	67,635,611 bp from pter
End:	67,669,026 bp from pter
Size:	33,416 bases
Orientation:	plus strand

RefSeq DNA sequence:

NC_000023.9 NT_011669.16

(According to ¹UniProtKB, and/or Ensembl, Phosphorylation sites according to ²Phosphosite, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Enzo Life Sciences, Abnova, OriGene and/or, Abcam,
Biochemical Assays by Invitrogen, Millipore, R&D Systems, Cell Signaling Technology, and/or Enzo Life Sciences, Ontologies according to Gene Ontology Consortium 01 Apr 2009 and Entrez Gene, Antibodies by Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Cell Signaling Technology, Abcam, Abnova, and/or Novus Biologicals)
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UniProtKB/Swiss-Prot: YIPF6_HUMAN, Q96EC8 (See protein sequence)

Recommended Name: Protein YIPF6

Size: 236 amino acids; 26256 Da

Subcellular location: Membrane; Multi-pass membrane protein (Potential)

Secondary accessions: Q5JP08

Post-translational modifications:

View phosphorylation sites using PhosphoSite²

REFSEQ proteins: NP_776195.1

ENSEMBL proteins:

ENSP00000363751 ENSP00000363774

Human Recombinant Proteins

	Browse Drug Discovery Central at Invitrogen for human recombinant proteins
	Browse Purified and Recombinant Proteins at Millipore
	Browse Human Recombinant Proteins at Sigma-Aldrich
	Browse R&D Systems for human recombinant proteins
	Browse recombinant and purified proteins available from Enzo Life Sciences
	Recombinant Proteins from Abcam (YIPF6)
	Browse Abnova for Human Recombinant Proteins

Browse Origene for full length recombinant human proteins expressed in human HEK293 cells

5/6 Gene Ontology (GO) cellular component terms (links to tree view) (see all 6 ):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005634	nucleus	IDA	18029348
GO:0005730	nucleolus	IDA	18029348
GO:0005737	cytoplasm	IDA	18029348
GO:0005783	endoplasmic reticulum	IDA	11256614
GO:0016020	membrane	IEA	--

About this table

Antibodies for YIPF6:

	Browse Antibodies Central at Invitrogen
	Browse Millipore's Extensive Line of Mono- and Polyclonal Antibodies
	Sigma-Aldrich Antibodies for YIPF6
	Browse R&D Systems for Antibodies
	Antibodies from Abcam (YIPF6), each with their Abpromise^SM
	Browse Abnova for Monoclonal and Polyclonal Antibodies
	Search Novus for antibodies for YIPF6

Assays for YIPF6:

	Browse Invitrogen for biochemical assays
	Browse Kits and Assays available from Millipore
	Browse R&D Systems for biochemical assays
	Browse biochemical assays available from Enzo Life Sciences

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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Graphical View of Domain Structure for InterPro Entry Q96EC8

ProtoNet protein and cluster: Q96EC8

UniProtKB/Swiss-Prot: YIPF6_HUMAN, Q96EC8

Similarity: Belongs to the YIP1 family

(According to MGI Jun 06 2009, UniProtKB, IUBMB,and/or Genatlas,
shRNA from OriGene, Sigma-Aldrich, RNAi from Sigma-Aldrich,
RNAi Products, Clones, and Q-PCR Products from Invitrogen, Millipore, OriGene, and/or Abnova, siRNAs from Applied Biosystems, SYBR primers from OriGene, Cell-based Assays from Millipore, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
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Inhib. RNA:		Invitrogen RNAi Products for gene knock-down (YIPF6)
		Browse for Gene Knock-down Tools from Millipore
		Browse Abnova for Chimera RNAi Products

OriGene 29mer shRNA kit in GFP-retroviral vectors (see all 2): NM_173834

Applied Biosystems Silencer® siRNAs for YIPF6

Sigma-Aldrich siRNA for YIPF6

Browse shRNA at Sigma-Aldrich

Explore Sigma-Aldrich super-pooled esiRNAs

Clones:		Browse Clone Ranger at Invitrogen for clones
		Browse Clones for the Expression of Recombinant Proteins Available from Millipore

OriGene GFP tagged cDNA clone in CMV expression vector: NM_173834
Myc/DDK tagged cDNA clone in CMV expression vector: NM_173834
untagged cDNA clones in CMV expression vector (see all 3): BC012469

Primers:

Browse Quantitative PCR Central at Invitrogen for Q-PCR LUX™ Primers

OriGene genome-wide validated SYBR primer pairs: BC012469

(Pathways according to Invitrogen (maps by GeneGo), Millipore, Cell Signaling Technology, Sigma-Aldrich, KEGG and/or UniProtKB,
Sets of similar genes according to GeneDecks, Proteins Network according to SABiosciences, Interactions according to ¹UniProtKB, ²MINT, and/or ³STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
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(Chemical Compounds according to UniProtKB, Enzo Life Sciences, Sigma-Aldrich, Tocris Bioscience, and/or Novoseek and Drugs according to Enzo Life Sciences and/or PharmGKB)
About This Section

Browse drugs & compounds from Enzo Life Sciences

Browse Small Molecules at Sigma-Aldrich

Browse Tocris compounds for YIPF6

(GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 219 Homo sapiens; Jun 2 2009) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView,
non coding RNAs according to RNAdb,
ESTs according to GeneTide,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from Invitrogen, Millipore, and/or Abnova,
siRNAs from Applied Biosystems, Sigma-Aldrich,
shRNA from Sigma-Aldrich, OriGene,
Tagged/untagged cDNA clones from OriGene,
Expression Assays from Applied Biosystems)
About This Section

Inhib. RNA:		Invitrogen RNAi Products for gene knock-down (YIPF6)
		Browse for Gene Knock-down Tools from Millipore
		Browse Abnova for Chimera RNAi Products

OriGene 29mer shRNA kit in GFP-retroviral vectors (see all 2): NM_173834

Sigma-Aldrich siRNA for YIPF6

Browse shRNA at Sigma-Aldrich

Explore Sigma-Aldrich super-pooled esiRNAs

Applied Biosystems Silencer® siRNAs:

NM_173834

REFSEQ mRNAs for YIPF6 gene:

NM_173834.2

Applied Biosystems TaqMan ® Gene Expression Assays:

NM_173834

              OriGene GFP tagged cDNA clone in CMV expression vector: NM_173834
                                 Myc/DDK tagged cDNA clone in CMV expression vector: NM_173834
                                 untagged cDNA clones in CMV expression vector (see all 3): BC012469

Additional cDNA sequence:

AK024673.1 AK095555.1 AK292835.1 AK303992.1 BC012469.1

16 DOTS entries:

DT.443024 DT.215833 DT.311510 DT.100789520 DT.121291193 DT.100789541 DT.100036446 DT.100789521

DT.452543 DT.100789518 DT.121291202 DT.121291205 DT.95277966 DT.121291183 DT.121291208 DT.121295884

24/288 AceView cDNA sequences (see all 288 ):

CB156714 AI499522 BM984382 AA349738 CB160821 AA741193 AI670729 AW136627

AW130003 BG109860 AI129260 BM476596 BI791510 BM992539 F07812 CF128035

BU168281 AK024673 BF793582 AA758041 AI758231 CD105283 CB069787 BU726870

highest scoring ESTs for YIPF6:

AA195936 AA206548 AA327784 AA349738 AA531461 AA577682 AA976229 AI193251 AI246516 AI590122

Unigene Clusters for YIPF6:

Yip1 domain family, member 6

Hs.82719 [show with all ESTs], Hs.700646 [show with all ESTs]

Unigene Representative Sequences: AL117461, AK095555

GeneLoc Exon Structure

4 Alternative Splicing Database (ASD) splice patterns (SP) for YIPF6

ExUns:	1a	·	1b	·	1c	^	2	^	3a	·	3b	·	3c	^	4	^	5	^	6a	·	6b	^	7
SP1:					-						-		-						-
SP2:					-						-		-
SP3:
SP4:					-

About this scheme

ECgene alternative splicing isoforms for YIPF6

2 Ensembl transcripts including schematic representations:

ENST00000374622 ENST00000374643

(Experimental results according to ¹GeneNote and GNF BioGPS,
probe sets-to-genes annotations according to ²GeneAnnot , ³GeneTide , Sets of similar genes according to GeneDecks, Electronic Northern calculations according to data from UniGene (Build 219 Homo sapiens), SAGE tags according to CGAP, plus additional links to SOURCE, and/or GNF BioGPS, and/or EXPOLDB, and/or UniProtKB,
Expression Assays from Applied Biosystems )
About This Section

YIPF6 expression in normal and diseased human tissues

Applied Biosystems TaqMan ® Gene Expression Assays for YIPF6

¹ / ² / ³

14 probe-sets matching YIPF6 gene

Affymetrix probe-set	Array	# genes	Sensitivity	Specificity	Correlation	Length	Gb_Accession	Consensus	Uniqueness	Score	Rank
Affymetrix probe-set	Array	GeneAnnot data			GeneNote data		GeneTide data
59068_r_at²^{, 3}	U95-B	1	1.00	1.00	0.60	0.97	AI743307	0.80	1.00	0.91	1
59066_at²^{, 3}	U95-B	1	1.00	1.00	0.51	1.16	AL036615	0.80	1.00	0.91	1
59067_f_at²^{, 3}	U95-B	2	1.00	0.81	0.77	1.05	AI743307	0.80	1.00	0.91	1
62938_at²^{, 3}	U95-C	1	0.88	1.00	0.63	0.57	AA577682	0.80	1.00	0.91	1
74328_f_at²^{, 3}	U95-D	1	0.27	1.00	-0.22	0.30	AW026528	0.20	1.00	0.72	1
37891_at*²^{, 3}	U95-A	3	1.00	0.33	0.59	1.29	U79272	0.60	1.00	0.82	1
212340_at²^{, 3}	U133-A	1	1.00	1.00	--	--	BE673723	0.60	1.00	0.82	1
212341_at²^{, 3}	U133-A	1	1.00	1.00	--	--	AA195936	0.80	1.00	0.91	1
212342_at²^{, 3}	U133-A	1	1.00	1.00	--	--	BG500611	0.60	1.00	0.82	1
212343_at*²^{, 3}	U133-A	3	1.00	0.33	--	--	AL117461	0.60	1.00	0.82	1
212340_at²	U133Plus2	1	1.00	1.00	--	--	--	--	--	--	--
212341_at²	U133Plus2	1	1.00	1.00	--	--	--	--	--	--	--
212342_at²	U133Plus2	1	1.00	1.00	--	--	--	--	--	--	--
212343_at*²	U133Plus2	3	1.00	0.33	--	--	--	--	--	--	--

GeneDecks YIPF6 for binary patterns associated with the probe-sets selected above

About GeneDecksing

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Data from

(Publications) and GNF BioGPS
About these images
About these images

CGAP SAGE TAG: AACCCAAGAG

SOURCE GeneReport for Unigene clusters: Hs.82719 Hs.700646

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD and/or ⁵MGI Jun 06 2009, with possible further links to Flybase and/or WormBase, Gene Trees according to Ensembl)
About This Section

Orthologs for YIPF6 gene from 5/17 species (see all 17 )

Organism	Gene	Locus	Description	Human Similarity	NCBI accessions
dog (Canis familiaris)	YIPF6¹	--	Yip1 domain family, member 6	91.53(n) 93.64(a)	491931 XM_549051.2 XP_549051.2
chimpanzee (Pan troglodytes)	YIPF6¹	--	Yip1 domain family, member 6	99.72(n) 99.58(a)	465681 XM_521102.2 XP_521102.1
cow (Bos taurus)	YIPF6¹	--	Yip1 domain family, member 6	92.66(n) 94.07(a)	540347 XM_593379.3 XP_593379.2
rat (Rattus norvegicus)	Yipf6¹	--	Yip1 domain family, member 6	78.01(n) 81.28(a)	363476 NM_001025747.1 NP_001020918.1
mouse (Mus musculus)	Yipf6^{1, 5}	X⁵	Yip1 domain family, member 6^{1, 5}	77.45(n)¹ 83.4(a)¹	77929¹ NM_207633.2¹ NP_997516.1¹ AI428112⁵ AK020780⁵ (see all 18)

About this table Species with no ortholog for YIPF6

ENSEMBL Gene Tree for YIPF6

(Paralogs according to ¹HomoloGene
and ²Ensembl, Pseudogenes according to ³Pseudogene.org)
About This Section

Paralogs for YIPF6 gene

YIPF4²

(According to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, and UniProtKB, Linkage Disequilibrium by HapMap, Genotyping Reagents from Applied Biosystems)
About This Section

10/68 NCBI SNPs in YIPF6 are shown (see all 68 )
(Click for Applied Biosystems TaqMan ® Genotyping Assay) (see all 30)

AB	SNP ID	Valid	Chr X pos	Sequence	Recs	AA Chg	Type	More	Recs	Pop	Total sample	More
AB	Genomic Data				Transcription Data				Allele Frequencies
				--	--	--		--	--			--
	rs5918840^1,2	A,C,F,H	67634890(+)	`GAAGAC/TTATCT`	1	--	ng5¹		4	EU EA WA	420
	rs4306042^1,2	A,C,F,H	67633613(+)	`ATGACC/TGTAGG`	1	--	ng5¹		12	EU EA WA NA	948
	rs6625338^1,2	H	67634930(+)	`TTTTAG/AACCCT`	1	--	ng5¹ ese³		4	EU EA WA	420
	rs4390083^1,2	A,C,F,H	67643855(+)	`tttacC/Tttcat`	1	--	int¹		7	EU EA WA NA	535
	rs6625340^1,2	A,C,F,H	67642969(+)	`tctctG/Aaaaga`	1	--	int¹		4	EU EA WA	418
--	rs4827580^1,2	A,C,F,H	67650509(+)	`TAAATG/ATACAC`	1	--	int¹		7	EU EA WA NA	560
	rs7055305^1,2	A,C,F,H	67640226(+)	`aactgC/Tacagg`	1	--	int¹		7	EU EA WA NA	560
	rs12843249^1,2	A,C,F,H	67635810(+)	`TTCTTT/GTACCC`	1	--	int¹		4	EU EA WA	412
--	rs6624368^1,2	A,C,F	67667574(+)	`ACATAT/CTGCAG`	1	--	int¹		3	NA	142
--	rs5964679^1,2	A,C,H	67643460(+)	`tatagG/Atgtgt`	1	--	int¹		1	EU	120

About this table

HapMap Linkage Disequilibrium images for YIPF6 (up to first 250kb)

(in which this Gene is Involved, According to OMIM, UniProtKB, PharmGKB, Genatlas, GeneTests, Blood group antigen gene mutations by BGMUT, HGMD, GAD, HuGE Navigator, BCGD, and/or TGDB.)
About This Section

(Possibly Related Articles in Doctor's Guide)
About This Section

(in PubMed. Associations of this gene to articles via ¹Novoseek, ²HGNC, ³Entrez Gene, ⁴UniProtKB/Swiss-Prot, ⁵UniProtKB/TrEMBL, ⁶GAD, and/or ⁷PharmGKB)
About This Section

10 PubMed articles for YIPF6 gene:

The DNA sequence of the human X chromosome. (PubMed id 15772651)^{3, 4} Ross M.T.... Bentley D.R. (2005)
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)^{3, 4} Gerhard D.S....Malek J. (2004)
Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)^{2, 3} Strausberg R.L....Marra M.A. (2002)
Toward a confocal subcellular atlas of the human proteome. (PubMed id 18029348)³ Barbe L....Andersson-Svahn H. (2008)
The LIFEdb database in 2006. (PubMed id 16381901)³ Mehrle A....Wiemann S. (2006)
Towards a proteome-scale map of the human protein-protein interaction network. (PubMed id 16189514)³ Rual J.F....Vidal M. (2005)
Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)³ Ota T....Sugano S. (2004)
From ORFeome to biology: a functional genomics pipeline. (PubMed id 15489336)³ Wiemann S....Poustka A. (2004)
Systematic subcellular localization of novel proteins identified by large-scale cDNA sequencing. (PubMed id 11256614)³ Simpson J.C.... Wiemann S. (2000)
DNA cloning using in vitro site-specific recombination. (PubMed id 11076863)³ Hartley J.L....Brasch M.A. (2000)

(in PubMed, OMIM, and NCBI Bookshelf)
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		AND	OR
Aliases
Free Text

Query String		PubMed OMIM NCBI Bookshelf
	(Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, and/or H-InvDB)
About This Section

Entrez Gene: 286451	HGNC: 28304	AceView: MGC21416	Ensembl:ENSG00000181704	euGenes: HUgn286451
ECgene: YIPF6	H-InvDB: YIPF6

(According to HUGE)
About This Section

(According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section

Licensable Technologies for YIPF6
(Available from WIS Yeda, Salk, Tufts)

About This Section

(Reagents available from Applied Biosystems, Antibodies and assays by Cell Signaling Technology, Abcam, Novus Biologicals,
Sigma-Aldrich, R&D Systems, Millipore, Abnova, and/or Invitrogen, Clones available from OriGene,and/or Invitrogen, Drugs and/or compounds by Sigma-Aldrich,
Enzo Life Sciences, and/or Tocris Bioscience)
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Products for YIPF6:

TaqMan ® Gene Expression Assays

TaqMan ® Genotyping Assays

Free SNP selection tool

Invitrogen iPath Pathways	Invitrogen BLOCK-iT™ RNAi
Invitrogen Antibodies	Invitrogen Assays
Invitrogen Clones	Invitrogen Q-PCR Products
Invitrogen Human Recombinant Kinases	Invitrogen Custom Antibody and Peptide Service
Invitrogen Proteins / Assays / Screening Services	Search Invitrogen catalog for YIPF6-related products

	Millipore Custom Antibody & Bulk Services
	Millipore Preclinical / Clinical Development Services
	Millipore Immunoassay Services
	Millipore Target Screening & Profiling Services

	Predesigned and custom siRNAs for YIPF6		Antibodies for YIPF6
	Explore super-pooled esiRNAs		Browse proteins at Sigma-Aldrich
	Browse shRNAs at Sigma-Aldrich		Browse small molecules at Sigma-Aldrich
	"Your Favorite Gene" Pathways		feedback

	Antibodies		Primer Pairs
	Cell Culture Products		ELISAs
	Flow Cytometry Kits		Protease Activity Assays & Reagents
	Cell Selection/Detection Kits & Reagents		ELISA/Assay Development Kits & Reagents
	Multiplex/Array Assay Kits & Reagents		ELISpot Kits & Development Modules
	Recombinant & Natural Proteins

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	Custom Service for Rabbit Pab from Full-length Protein

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Search www.enzolifesicences.com for proteins, assays, substrates, inhibitors & antibodies

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YIPF6 Gene

protein-coding GIFtS: 46

Aliases &
Descriptions
for YIPF6

Summaries
for YIPF6

Genomic Location
for YIPF6

Proteins
for YIPF6

Protein Domains/
Families
for YIPF6

Gene Function
for YIPF6

Pathways & Interactions
for YIPF6

Drugs & Compounds
for YIPF6

Transcripts
for YIPF6

Expression
for YIPF6

Orthologs
for YIPF6

Paralogs
for YIPF6

SNPs/Variants
for YIPF6

Disorders & Mutations
for YIPF6

Medical News
for YIPF6

Publications
for YIPF6

Search for YIPF6

Genome Databases showing YIPF6

Other Databases showing YIPF6

Specialized Databases showing YIPF6

Licensable Technologies
for YIPF6

Services
for YIPF6

Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

YIPF6 Gene

protein-coding GIFtS: 46

Aliases & Descriptionsfor YIPF6

Summariesfor YIPF6

Genomic Locationfor YIPF6

Proteinsfor YIPF6

Protein Domains/Familiesfor YIPF6

Gene Functionfor YIPF6

Pathways & Interactionsfor YIPF6

Drugs & Compoundsfor YIPF6

Transcriptsfor YIPF6

Expression for YIPF6

Orthologsfor YIPF6

Paralogsfor YIPF6

SNPs/Variantsfor YIPF6

Disorders & Mutationsfor YIPF6

Medical Newsfor YIPF6

Publicationsfor YIPF6

Search for YIPF6

Genome Databases showing YIPF6

Other Databases showing YIPF6

Specialized Databases showing YIPF6

Licensable Technologiesfor YIPF6

Servicesfor YIPF6

Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

Aliases &
Descriptions
for YIPF6

Summaries
for YIPF6

Genomic Location
for YIPF6

Proteins
for YIPF6

Protein Domains/
Families
for YIPF6

Gene Function
for YIPF6

Pathways & Interactions
for YIPF6

Drugs & Compounds
for YIPF6

Transcripts
for YIPF6

Expression
for YIPF6

Orthologs
for YIPF6

Paralogs
for YIPF6

SNPs/Variants
for YIPF6

Disorders & Mutations
for YIPF6

Medical News
for YIPF6

Publications
for YIPF6

Licensable Technologies
for YIPF6

Services
for YIPF6