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Aliases for YIPF6 Gene

Aliases for YIPF6 Gene

  • Yip1 Domain Family Member 6 2 3 5
  • YIP1 Family Member 6 3 4
  • Yip1 Domain Family, Member 6 2
  • Protein YIPF6 3
  • FinGER6 3

External Ids for YIPF6 Gene

Previous GeneCards Identifiers for YIPF6 Gene

  • GC0XP067502
  • GC0XP067634
  • GC0XP067718
  • GC0XP061546

Summaries for YIPF6 Gene

GeneCards Summary for YIPF6 Gene

YIPF6 (Yip1 Domain Family Member 6) is a Protein Coding gene. Among its related pathways are Vesicle-mediated transport and Clathrin derived vesicle budding. GO annotations related to this gene include identical protein binding.

Gene Wiki entry for YIPF6 Gene

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for YIPF6 Gene

Genomics for YIPF6 Gene

Regulatory Elements for YIPF6 Gene

Enhancers for YIPF6 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH0XF068462 1.3 Ensembl ENCODE 13.2 -35.7 -35700 0.5 ATF1 PKNOX1 ZNF133 FEZF1 GLI4 ZNF2 YY1 GTF3C2 ZNF121 ZNF302 YIPF6 LOC100128467 OPHN1
GH0XF069284 1.1 Ensembl ENCODE 9.9 +787.5 787469 1.8 CTCF KLF17 ZMYM3 ZNF514 BCL11B RAD21 FOSL1 ZFHX2 GLIS2 PATZ1 OTUD6A YIPF6 FAM155B PIR50037 GC0XM069229
GH0XF068416 0.9 Ensembl ENCODE 11.8 -81.6 -81589 0.3 STAT1 JUN CEBPB MAX RAD21 EP300 RFX5 JUND STAT3 YIPF6 OPHN1 ENSG00000206646
GH0XF068438 0.8 ENCODE 12.2 -59.4 -59412 1.6 HDAC1 KLF1 LEF1 ZNF146 PKNOX1 TAL1 ETV1 GATA2 NCOR1 PRDM10 YIPF6 OPHN1 LOC100128467
GH0XF068646 0.7 ENCODE 11.7 +149.4 149398 1.6 UBTF ZIC2 GLIS2 ZBTB48 POLR2A NFYB E2F6 ZBTB20 ZNF263 SP3 YIPF6 STARD8 ACTR3P2
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around YIPF6 on UCSC Golden Path with GeneCards custom track

Promoters for YIPF6 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00001490247 678 2400 PKNOX1 ATF1 CREB3L1 MLX ARID4B SIN3A DMAP1 ZNF48 BRCA1 ZNF2

Genomic Location for YIPF6 Gene

Chromosome:
X
Start:
68,498,323 bp from pter
End:
68,572,330 bp from pter
Size:
74,008 bases
Orientation:
Plus strand

Genomic View for YIPF6 Gene

Genes around YIPF6 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
YIPF6 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for YIPF6 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for YIPF6 Gene

Proteins for YIPF6 Gene

  • Protein details for YIPF6 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q96EC8-YIPF6_HUMAN
    Recommended name:
    Protein YIPF6
    Protein Accession:
    Q96EC8
    Secondary Accessions:
    • B4E1U7
    • G5E997
    • Q5JP08

    Protein attributes for YIPF6 Gene

    Size:
    236 amino acids
    Molecular mass:
    26256 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for YIPF6 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for YIPF6 Gene

Post-translational modifications for YIPF6 Gene

  • Glycosylation at Asn 55 and Asn 144
  • Modification sites at PhosphoSitePlus

Other Protein References for YIPF6 Gene

No data available for DME Specific Peptides for YIPF6 Gene

Domains & Families for YIPF6 Gene

Gene Families for YIPF6 Gene

Protein Domains for YIPF6 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for YIPF6 Gene

Graphical View of Domain Structure for InterPro Entry

Q96EC8

UniProtKB/Swiss-Prot:

YIPF6_HUMAN :
  • Belongs to the YIP1 family.
Family:
  • Belongs to the YIP1 family.
genes like me logo Genes that share domains with YIPF6: view

Function for YIPF6 Gene

Gene Ontology (GO) - Molecular Function for YIPF6 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 16189514
GO:0042802 identical protein binding IEA --
genes like me logo Genes that share ontologies with YIPF6: view
genes like me logo Genes that share phenotypes with YIPF6: view

Animal Model Products

miRNA for YIPF6 Gene

miRTarBase miRNAs that target YIPF6

Inhibitory RNA Products

Flow Cytometry Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for YIPF6 Gene

Localization for YIPF6 Gene

Subcellular locations from UniProtKB/Swiss-Prot for YIPF6 Gene

Membrane; Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for YIPF6 gene
Compartment Confidence
endoplasmic reticulum 4
golgi apparatus 3
plasma membrane 2
nucleus 2

Gene Ontology (GO) - Cellular Components for YIPF6 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005783 endoplasmic reticulum IDA --
GO:0005801 cis-Golgi network IEA --
GO:0005802 trans-Golgi network IEA --
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with YIPF6: view

Pathways & Interactions for YIPF6 Gene

genes like me logo Genes that share pathways with YIPF6: view

Gene Ontology (GO) - Biological Process for YIPF6 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0060576 intestinal epithelial cell development IEA --
genes like me logo Genes that share ontologies with YIPF6: view

No data available for SIGNOR curated interactions for YIPF6 Gene

Transcripts for YIPF6 Gene

Unigene Clusters for YIPF6 Gene

Yip1 domain family, member 6:
Representative Sequences:

Inhibitory RNA Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for YIPF6 Gene

ExUns: 1a · 1b · 1c ^ 2 ^ 3a · 3b · 3c ^ 4 ^ 5 ^ 6a · 6b ^ 7
SP1: - - - -
SP2: - - -
SP3:
SP4: -

Relevant External Links for YIPF6 Gene

GeneLoc Exon Structure for
YIPF6
ECgene alternative splicing isoforms for
YIPF6

Expression for YIPF6 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for YIPF6 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for YIPF6 Gene

This gene is overexpressed in Nasal epithelium (60.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for YIPF6 Gene



NURSA nuclear receptor signaling pathways regulating expression of YIPF6 Gene:

YIPF6

SOURCE GeneReport for Unigene cluster for YIPF6 Gene:

Hs.82719
genes like me logo Genes that share expression patterns with YIPF6: view

No data available for mRNA differential expression in normal tissues , Protein tissue co-expression partners and mRNA Expression by UniProt/SwissProt for YIPF6 Gene

Orthologs for YIPF6 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for YIPF6 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia YIPF6 34 35
  • 99.86 (n)
cow
(Bos Taurus)
Mammalia YIPF6 34 35
  • 92.8 (n)
dog
(Canis familiaris)
Mammalia YIPF6 34 35
  • 91.67 (n)
oppossum
(Monodelphis domestica)
Mammalia YIPF6 35
  • 79 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Yipf6 34
  • 78.16 (n)
mouse
(Mus musculus)
Mammalia Yipf6 34 16 35
  • 77.59 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia YIPF6 35
  • 48 (a)
OneToOne
chicken
(Gallus gallus)
Aves YIPF6 34 35
  • 73.36 (n)
lizard
(Anolis carolinensis)
Reptilia YIPF6 35
  • 80 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia yipf6 34
  • 70.16 (n)
Str.8591 34
African clawed frog
(Xenopus laevis)
Amphibia Xl.15800 34
zebrafish
(Danio rerio)
Actinopterygii yipf6 34 35
  • 69.89 (n)
Dr.12316 34
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP008226 34
  • 56.13 (n)
fruit fly
(Drosophila melanogaster)
Insecta CG3652 34 35
  • 55.44 (n)
worm
(Caenorhabditis elegans)
Secernentea W02D9.2 34 35
  • 52.41 (n)
thale cress
(Arabidopsis thaliana)
eudicotyledons AT2G18840 34
  • 50.98 (n)
rice
(Oryza sativa)
Liliopsida Os01g0867700 34
  • 47.01 (n)
fission yeast
(Schizosaccharomyces pombe)
Schizosaccharomycetes SPAC644.13c 34
  • 53.17 (n)
sea squirt
(Ciona savignyi)
Ascidiacea -- 35
  • 53 (a)
OneToOne
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.4967 34
Species where no ortholog for YIPF6 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for YIPF6 Gene

ENSEMBL:
Gene Tree for YIPF6 (if available)
TreeFam:
Gene Tree for YIPF6 (if available)

Paralogs for YIPF6 Gene

No data available for Paralogs for YIPF6 Gene

Variants for YIPF6 Gene

Sequence variations from dbSNP and Humsavar for YIPF6 Gene

SNP ID Clin Chr 0X pos Sequence Context AA Info Type
rs10531 -- 68,536,980(-) TTCTC(A/C)CACTA intron-variant, utr-variant-3-prime
rs10547130 -- 68,548,499(+) AAAAA(-/AA)GACTT intron-variant
rs111351787 -- 68,521,422(+) CCAAT(G/T)TGCAG reference, missense
rs111400326 -- 68,532,457(+) ATGGT(C/T)TATAT intron-variant, utr-variant-3-prime
rs111691377 -- 68,562,964(+) AAGAT(C/T)CTGCT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for YIPF6 Gene

Variant ID Type Subtype PubMed ID
esv3332626 CNV insertion 20981092
esv1584074 OTHER inversion 17803354

Variation tolerance for YIPF6 Gene

Residual Variation Intolerance Score: 64.9% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.23; 5.15% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for YIPF6 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
YIPF6

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for YIPF6 Gene

Disorders for YIPF6 Gene

Relevant External Links for YIPF6

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
YIPF6

No disorders were found for YIPF6 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for YIPF6 Gene

Publications for YIPF6 Gene

  1. The DNA sequence of the human X chromosome. (PMID: 15772651) Ross M.T. … Bentley D.R. (Nature 2005) 3 4 64
  2. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4 64
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4 64
  4. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg R.L. … Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002) 2 3 64
  5. Control of a neuronal morphology program by an RNA-binding zinc finger protein, Unkempt. (PMID: 25737280) Murn J. … Shi Y. (Genes Dev. 2015) 3 64

Products for YIPF6 Gene

Sources for YIPF6 Gene

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