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Aliases for YIPF5 Gene

Aliases for YIPF5 Gene

  • Yip1 Domain Family Member 5 2 3 5
  • Five-Pass Transmembrane Protein Localizing In The Golgi Apparatus And The Endoplasmic Reticulum 5 3 4
  • Smooth Muscle Cell-Associated Protein 5 3 4
  • Yip1 Domain Family, Member 5 2 3
  • YPT-Interacting Protein 1 A 3 4
  • YIP1 Family Member 5 3 4
  • FinGER5 3 4
  • SMAP-5 3 4
  • YIP1A 3 4
  • Smooth Muscle Cell Associated Protein 5 3
  • Golgi Membrane Protein SB140 3
  • SB140 3
  • SMAP5 3

External Ids for YIPF5 Gene

Previous GeneCards Identifiers for YIPF5 Gene

  • GC05M143520
  • GC05M138685

Summaries for YIPF5 Gene

GeneCards Summary for YIPF5 Gene

YIPF5 (Yip1 Domain Family Member 5) is a Protein Coding gene. Diseases associated with YIPF5 include pleomorphic adenoma carcinoma. An important paralog of this gene is YIPF7.

UniProtKB/Swiss-Prot for YIPF5 Gene

  • Plays a role in transport between endoplasmic reticulum and Golgi.

Gene Wiki entry for YIPF5 Gene

No data available for Entrez Gene Summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for YIPF5 Gene

Genomics for YIPF5 Gene

Regulatory Elements for YIPF5 Gene

Promoters for YIPF5 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around YIPF5 on UCSC Golden Path with GeneCards custom track

Genomic Location for YIPF5 Gene

Chromosome:
5
Start:
144,158,159 bp from pter
End:
144,170,714 bp from pter
Size:
12,556 bases
Orientation:
Minus strand

Genomic View for YIPF5 Gene

Genes around YIPF5 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
YIPF5 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for YIPF5 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for YIPF5 Gene

Proteins for YIPF5 Gene

  • Protein details for YIPF5 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q969M3-YIPF5_HUMAN
    Recommended name:
    Protein YIPF5
    Protein Accession:
    Q969M3
    Secondary Accessions:
    • D3DQF5
    • Q4VSN6
    • Q53EX4
    • Q8NHE5
    • Q9H338
    • Q9H3U4

    Protein attributes for YIPF5 Gene

    Size:
    257 amino acids
    Molecular mass:
    27989 Da
    Quaternary structure:
    • Interacts with the COPII coat components Sec23 (SEC23A and/or SEC23B) and Sec24 (SEC24A and/or SEC24B). Interacts with YIF1A. May interact with RAB1A.

    Alternative splice isoforms for YIPF5 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for YIPF5 Gene

Proteomics data for YIPF5 Gene at MOPED

Post-translational modifications for YIPF5 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for YIPF5 Gene

No data available for DME Specific Peptides for YIPF5 Gene

Domains & Families for YIPF5 Gene

Gene Families for YIPF5 Gene

Protein Domains for YIPF5 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for YIPF5 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q969M3

UniProtKB/Swiss-Prot:

YIPF5_HUMAN :
  • Belongs to the YIP1 family.
Family:
  • Belongs to the YIP1 family.
genes like me logo Genes that share domains with YIPF5: view

Function for YIPF5 Gene

Molecular function for YIPF5 Gene

UniProtKB/Swiss-Prot Function:
Plays a role in transport between endoplasmic reticulum and Golgi.
UniProtKB/Swiss-Prot Induction:
By TGFB1.
genes like me logo Genes that share phenotypes with YIPF5: view

Animal Models for YIPF5 Gene

MGI Knock Outs for YIPF5:

Animal Model Products

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for YIPF5 Gene

Localization for YIPF5 Gene

Subcellular locations from UniProtKB/Swiss-Prot for YIPF5 Gene

Endoplasmic reticulum membrane; Multi-pass membrane protein. Golgi apparatus, Golgi stack membrane; Multi-pass membrane protein. Cytoplasmic vesicle, COPII-coated vesicle. Note=Enriched at the endoplasmic reticulum exit sites. Incorporated into COPII coated vesicles.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for YIPF5 Gene COMPARTMENTS Subcellular localization image for YIPF5 gene
Compartment Confidence
endoplasmic reticulum 5
golgi apparatus 5
plasma membrane 3

Gene Ontology (GO) - Cellular Components for YIPF5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005789 endoplasmic reticulum membrane IEA --
GO:0016021 integral component of membrane IEA --
GO:0030134 ER to Golgi transport vesicle IEA --
GO:0070971 endoplasmic reticulum exit site IEA --
genes like me logo Genes that share ontologies with YIPF5: view

Pathways & Interactions for YIPF5 Gene

SuperPathways for YIPF5 Gene

No Data Available

Gene Ontology (GO) - Biological Process for YIPF5 Gene

None

No data available for Pathways by source and SIGNOR curated interactions for YIPF5 Gene

Drugs & Compounds for YIPF5 Gene

No Compound Related Data Available

Transcripts for YIPF5 Gene

Unigene Clusters for YIPF5 Gene

Yip1 domain family, member 5:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for YIPF5 Gene

ExUns: 1a · 1b · 1c ^ 2 ^ 3a · 3b ^ 4a · 4b ^ 5a · 5b · 5c ^ 6a · 6b ^ 7a · 7b · 7c
SP1: - -
SP2: - - - -
SP3: - - - -
SP4: - -
SP5: -
SP6:

Relevant External Links for YIPF5 Gene

GeneLoc Exon Structure for
YIPF5
ECgene alternative splicing isoforms for
YIPF5

Expression for YIPF5 Gene

mRNA expression in normal human tissues for YIPF5 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for YIPF5 Gene

This gene is overexpressed in Bone (15.7).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for YIPF5 Gene



SOURCE GeneReport for Unigene cluster for YIPF5 Gene Hs.372050

mRNA Expression by UniProt/SwissProt for YIPF5 Gene

Q969M3-YIPF5_HUMAN
Tissue specificity: Ubiquitously expressed. Highly expressed in coronary smooth muscles.
genes like me logo Genes that share expression patterns with YIPF5: view

Protein tissue co-expression partners for YIPF5 Gene

- Elite partner

Primer Products

In Situ Assay Products

No data available for mRNA differential expression in normal tissues for YIPF5 Gene

Orthologs for YIPF5 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for YIPF5 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia YIPF5 36
  • 100 (a)
OneToOne
YIPF5 35
  • 99.87 (n)
  • 100 (a)
cow
(Bos Taurus)
Mammalia YIPF5 36
  • 97 (a)
OneToOne
YIPF5 35
  • 93.77 (n)
  • 97.28 (a)
dog
(Canis familiaris)
Mammalia YIPF5 35
  • 94.94 (n)
  • 98.05 (a)
YIPF5 36
  • 98 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Yipf5 16
Yipf5 35
  • 88.85 (n)
  • 92.61 (a)
Yipf5 36
  • 93 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia YIPF5 36
  • 93 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia YIPF5 36
  • 91 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Yipf5 35
  • 88.59 (n)
  • 91.44 (a)
chicken
(Gallus gallus)
Aves YIPF5 35
  • 81.63 (n)
  • 90.16 (a)
YIPF5 36
  • 90 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia YIPF5 36
  • 88 (a)
OneToOne
African clawed frog
(Xenopus laevis)
Amphibia smap-5-prov 35
tropical clawed frog
(Silurana tropicalis)
Amphibia Str.6252 35
yipf5 35
  • 75.65 (n)
  • 84.77 (a)
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.2330 35
zebrafish
(Danio rerio)
Actinopterygii yipf5 35
  • 73.18 (n)
  • 82.81 (a)
zgc56513 35
yipf5 36
  • 83 (a)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta CG12404 36
  • 42 (a)
OneToMany
CG12404 35
  • 51.27 (n)
  • 51.41 (a)
worm
(Caenorhabditis elegans)
Secernentea F32D8.14 36
  • 43 (a)
OneToMany
F32D8.14 35
  • 53.87 (n)
  • 49.37 (a)
A. gosspyii yeast
(Ashbya gossypii)
Saccharomycetes AGOS_AAL135C 35
  • 47.76 (n)
  • 44.16 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes YIP1 35
  • 48.84 (n)
  • 43.6 (a)
YIP1 36
  • 32 (a)
OneToMany
YIP1 38
K. lactis yeast
(Kluyveromyces lactis)
Saccharomycetes KLLA0F15015g 35
  • 48.72 (n)
  • 44.97 (a)
thale cress
(Arabidopsis thaliana)
eudicotyledons AT2G36300 35
  • 47.53 (n)
  • 37.8 (a)
rice
(Oryza sativa)
Liliopsida Os03g0289200 35
  • 45.1 (n)
  • 40.69 (a)
bread mold
(Neurospora crassa)
Ascomycetes NCU05514 35
  • 47.46 (n)
  • 45.76 (a)
fission yeast
(Schizosaccharomyces pombe)
Schizosaccharomycetes SPCC61.04c 35
  • 51.21 (n)
  • 42.73 (a)
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.3073 35
sea squirt
(Ciona savignyi)
Ascidiacea CSA.977 36
  • 51 (a)
OneToMany
Species with no ortholog for YIPF5:
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for YIPF5 Gene

ENSEMBL:
Gene Tree for YIPF5 (if available)
TreeFam:
Gene Tree for YIPF5 (if available)

Paralogs for YIPF5 Gene

Paralogs for YIPF5 Gene

(1) SIMAP similar genes for YIPF5 Gene using alignment to 3 proteins:

genes like me logo Genes that share paralogs with YIPF5: view

Variants for YIPF5 Gene

Sequence variations from dbSNP and Humsavar for YIPF5 Gene

SNP ID Clin Chr 05 pos Sequence Context AA Info Type
rs1043292 -- 144,159,578(-) CTCCA(A/G)AAATT utr-variant-3-prime
rs4122252 -- 144,166,854(+) TGAAA(C/T)TGACT intron-variant
rs4478353 -- 144,165,151(+) TCTCA(C/T)TTTTC intron-variant
rs4329041 -- 144,162,070(+) TTCTT(C/T)ATCCG intron-variant
rs4361555 -- 144,161,967(+) ACCAC(C/T)ATGAC intron-variant

Structural Variations from Database of Genomic Variants (DGV) for YIPF5 Gene

Variant ID Type Subtype PubMed ID
nsv882997 CNV Gain 21882294

Variation tolerance for YIPF5 Gene

Residual Variation Intolerance Score: 66.1% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.48; 28.88% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for YIPF5 Gene

HapMap Linkage Disequilibrium report
YIPF5

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for YIPF5 Gene

Disorders for YIPF5 Gene

MalaCards: The human disease database

(1) MalaCards diseases for YIPF5 Gene - From: DISEASES

Disorder Aliases PubMed IDs
pleomorphic adenoma carcinoma
  • carcinoma ex pleomorphic adenoma
- elite association - COSMIC cancer census association via MalaCards
Search YIPF5 in MalaCards View complete list of genes associated with diseases

Relevant External Links for YIPF5

Genetic Association Database (GAD)
YIPF5
Human Genome Epidemiology (HuGE) Navigator
YIPF5
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
YIPF5
genes like me logo Genes that share disorders with YIPF5: view

No data available for UniProtKB/Swiss-Prot and Genatlas for YIPF5 Gene

Publications for YIPF5 Gene

  1. The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment. (PMID: 12975309) Clark H.F. … Gray A.M. (Genome Res. 2003) 2 3 4 67
  2. YIPF5 and YIF1A recycle between the ER and the Golgi apparatus and are involved in the maintenance of the Golgi structure. (PMID: 18718466) Yoshida Y. … Nakamura N. (Exp. Cell Res. 2008) 2 3
  3. Yip1A, a novel host factor for the activation of the IRE1 pathway of the unfolded protein response during Brucella infection. (PMID: 25742138) Taguchi Y. … Murata M. (PLoS Pathog. 2015) 3
  4. Identification of discrete sites in Yip1A necessary for regulation of endoplasmic reticulum structure. (PMID: 23342155) Dykstra K.M. … Lee T.H. (PLoS ONE 2013) 3
  5. Mapping a dynamic innate immunity protein interaction network regulating type I interferon production. (PMID: 21903422) Li S. … Dorf M.E. (Immunity 2011) 3

Products for YIPF5 Gene

Sources for YIPF5 Gene

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