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Aliases for YIPF5 Gene

Aliases for YIPF5 Gene

  • Yip1 Domain Family Member 5 2 3 5
  • Five-Pass Transmembrane Protein Localizing In The Golgi Apparatus And The Endoplasmic Reticulum 5 3 4
  • YPT-Interacting Protein 1 A 3 4
  • YIP1 Family Member 5 3 4
  • FinGER5 3 4
  • SMAP-5 3 4
  • YIP1A 3 4
  • Smooth Muscle Cell Associated Protein 5 3
  • Smooth Muscle Cell-Associated Protein 5 4
  • Yip1 Domain Family, Member 5 2
  • Golgi Membrane Protein SB140 3
  • Protein YIPF5 3
  • SB140 3
  • SMAP5 3

External Ids for YIPF5 Gene

Previous GeneCards Identifiers for YIPF5 Gene

  • GC05M143520
  • GC05M138685

Summaries for YIPF5 Gene

GeneCards Summary for YIPF5 Gene

YIPF5 (Yip1 Domain Family Member 5) is a Protein Coding gene. Diseases associated with YIPF5 include Pleomorphic Adenoma Carcinoma. An important paralog of this gene is YIPF7.

UniProtKB/Swiss-Prot for YIPF5 Gene

  • Plays a role in transport between endoplasmic reticulum and Golgi.

Gene Wiki entry for YIPF5 Gene

No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for YIPF5 Gene

Genomics for YIPF5 Gene

Regulatory Elements for YIPF5 Gene

Enhancers for YIPF5 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH05G144187 2 FANTOM5 Ensembl ENCODE dbSUPER 28.2 -19.6 -19647 6.1 HDGF PKNOX1 FOXA2 SIN3A FEZF1 ZNF143 FOS DEK ZNF263 JUNB YIPF5 KCTD16 GC05P144326
GH05G144169 1 ENCODE 42.3 +0.4 396 2.3 HDGF PKNOX1 CREB3L1 WRNIP1 ARID4B SIN3A DMAP1 ZNF2 YY1 ZNF143 YIPF5 RN7SL87P
GH05G144198 0.8 FANTOM5 Ensembl 36.5 -27.9 -27908 0.8 PRDM6 KLF17 MAFK NFE2L2 TRIM28 YIPF5 KCTD16 GC05P144326
GH05G144139 0.6 ENCODE 19.7 +30.9 30939 1.0 CTCF POLR2A PBX2 FEZF1 HNF4A RAD21 YIPF5 RN7SL87P GC05P144101
GH05G144130 0.7 ENCODE 10.8 +40.3 40254 0.1 PKNOX1 ZBED1 JUNB RAD21 YY1 ZNF366 ATF3 EED TCF7 ETV6 YIPF5 KCTD16 NR3C1 RN7SL87P GC05P144101
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around YIPF5 on UCSC Golden Path with GeneCards custom track

Promoters for YIPF5 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000188378 414 1801 HDGF PKNOX1 CREB3L1 WRNIP1 ARID4B SIN3A DMAP1 ZNF2 YY1 ZNF143

Genomic Location for YIPF5 Gene

Chromosome:
5
Start:
144,158,159 bp from pter
End:
144,170,714 bp from pter
Size:
12,556 bases
Orientation:
Minus strand

Genomic View for YIPF5 Gene

Genes around YIPF5 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
YIPF5 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for YIPF5 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for YIPF5 Gene

Proteins for YIPF5 Gene

  • Protein details for YIPF5 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q969M3-YIPF5_HUMAN
    Recommended name:
    Protein YIPF5
    Protein Accession:
    Q969M3
    Secondary Accessions:
    • D3DQF5
    • Q4VSN6
    • Q53EX4
    • Q8NHE5
    • Q9H338
    • Q9H3U4

    Protein attributes for YIPF5 Gene

    Size:
    257 amino acids
    Molecular mass:
    27989 Da
    Quaternary structure:
    • Interacts with the COPII coat components Sec23 (SEC23A and/or SEC23B) and Sec24 (SEC24A and/or SEC24B). Interacts with YIF1A. May interact with RAB1A.

    Alternative splice isoforms for YIPF5 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for YIPF5 Gene

Post-translational modifications for YIPF5 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for YIPF5 Gene

No data available for DME Specific Peptides for YIPF5 Gene

Domains & Families for YIPF5 Gene

Gene Families for YIPF5 Gene

Protein Domains for YIPF5 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for YIPF5 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q969M3

UniProtKB/Swiss-Prot:

YIPF5_HUMAN :
  • Belongs to the YIP1 family.
Family:
  • Belongs to the YIP1 family.
genes like me logo Genes that share domains with YIPF5: view

Function for YIPF5 Gene

Molecular function for YIPF5 Gene

UniProtKB/Swiss-Prot Function:
Plays a role in transport between endoplasmic reticulum and Golgi.
UniProtKB/Swiss-Prot Induction:
By TGFB1.

Gene Ontology (GO) - Molecular Function for YIPF5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 23736259
genes like me logo Genes that share ontologies with YIPF5: view
genes like me logo Genes that share phenotypes with YIPF5: view

Animal Models for YIPF5 Gene

MGI Knock Outs for YIPF5:

Animal Model Products

CRISPR Products

Inhibitory RNA Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for YIPF5 Gene

Localization for YIPF5 Gene

Subcellular locations from UniProtKB/Swiss-Prot for YIPF5 Gene

Endoplasmic reticulum membrane; Multi-pass membrane protein. Golgi apparatus, Golgi stack membrane; Multi-pass membrane protein. Cytoplasmic vesicle, COPII-coated vesicle. Note=Enriched at the endoplasmic reticulum exit sites. Incorporated into COPII coated vesicles.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for YIPF5 gene
Compartment Confidence
endoplasmic reticulum 5
golgi apparatus 5
nucleus 4
plasma membrane 3

Gene Ontology (GO) - Cellular Components for YIPF5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005654 nucleoplasm IDA --
GO:0005783 endoplasmic reticulum IDA --
GO:0005789 endoplasmic reticulum membrane IEA --
GO:0005794 Golgi apparatus IDA --
GO:0016020 membrane IEA --
genes like me logo Genes that share ontologies with YIPF5: view

Pathways & Interactions for YIPF5 Gene

SuperPathways for YIPF5 Gene

No Data Available

Gene Ontology (GO) - Biological Process for YIPF5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006810 transport IEA --
GO:0015031 protein transport IEA --
GO:0016192 vesicle-mediated transport IEA --
GO:0060628 regulation of ER to Golgi vesicle-mediated transport IEA --
genes like me logo Genes that share ontologies with YIPF5: view

No data available for Pathways by source and SIGNOR curated interactions for YIPF5 Gene

Drugs & Compounds for YIPF5 Gene

No Compound Related Data Available

Transcripts for YIPF5 Gene

Unigene Clusters for YIPF5 Gene

Yip1 domain family, member 5:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Alternative Splicing Database (ASD) splice patterns (SP) for YIPF5 Gene

ExUns: 1a · 1b · 1c ^ 2 ^ 3a · 3b ^ 4a · 4b ^ 5a · 5b · 5c ^ 6a · 6b ^ 7a · 7b · 7c
SP1: - -
SP2: - - - -
SP3: - - - -
SP4: - -
SP5: -
SP6:

Relevant External Links for YIPF5 Gene

GeneLoc Exon Structure for
YIPF5
ECgene alternative splicing isoforms for
YIPF5

Expression for YIPF5 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for YIPF5 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for YIPF5 Gene

This gene is overexpressed in Bone (15.7).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for YIPF5 Gene



Protein tissue co-expression partners for YIPF5 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of YIPF5 Gene:

YIPF5

SOURCE GeneReport for Unigene cluster for YIPF5 Gene:

Hs.372050

mRNA Expression by UniProt/SwissProt for YIPF5 Gene:

Q969M3-YIPF5_HUMAN
Tissue specificity: Ubiquitously expressed. Highly expressed in coronary smooth muscles.

Evidence on tissue expression from TISSUES for YIPF5 Gene

  • Liver(4.4)
  • Heart(4.2)
  • Kidney(4.2)
  • Eye(4.1)
  • Nervous system(3.9)
genes like me logo Genes that share expression patterns with YIPF5: view

Primer Products

No data available for mRNA differential expression in normal tissues and Phenotype-based relationships between genes and organs from Gene ORGANizer for YIPF5 Gene

Orthologs for YIPF5 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for YIPF5 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia YIPF5 34 35
  • 99.87 (n)
dog
(Canis familiaris)
Mammalia YIPF5 34 35
  • 94.94 (n)
cow
(Bos Taurus)
Mammalia YIPF5 34 35
  • 93.77 (n)
oppossum
(Monodelphis domestica)
Mammalia YIPF5 35
  • 93 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia YIPF5 35
  • 91 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Yipf5 34 16 35
  • 88.85 (n)
rat
(Rattus norvegicus)
Mammalia Yipf5 34
  • 88.59 (n)
chicken
(Gallus gallus)
Aves YIPF5 34 35
  • 81.63 (n)
lizard
(Anolis carolinensis)
Reptilia YIPF5 35
  • 88 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia yipf5 34
  • 75.65 (n)
Str.6252 34
African clawed frog
(Xenopus laevis)
Amphibia smap-5-prov 34
zebrafish
(Danio rerio)
Actinopterygii yipf5 34 35
  • 73.18 (n)
zgc56513 34
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.2330 34
fruit fly
(Drosophila melanogaster)
Insecta CG12404 34 35
  • 51.27 (n)
worm
(Caenorhabditis elegans)
Secernentea F32D8.14 34 35
  • 53.87 (n)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes YIP1 34 35 37
  • 48.84 (n)
K. lactis yeast
(Kluyveromyces lactis)
Saccharomycetes KLLA0F15015g 34
  • 48.72 (n)
A. gosspyii yeast
(Ashbya gossypii)
Saccharomycetes AGOS_AAL135C 34
  • 47.76 (n)
thale cress
(Arabidopsis thaliana)
eudicotyledons AT2G36300 34
  • 47.53 (n)
rice
(Oryza sativa)
Liliopsida Os03g0289200 34
  • 45.1 (n)
fission yeast
(Schizosaccharomyces pombe)
Schizosaccharomycetes SPCC61.04c 34
  • 51.21 (n)
sea squirt
(Ciona savignyi)
Ascidiacea CSA.977 35
  • 51 (a)
OneToMany
bread mold
(Neurospora crassa)
Ascomycetes NCU05514 34
  • 47.46 (n)
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.3073 34
Species where no ortholog for YIPF5 was found in the sources mined by GeneCards:
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for YIPF5 Gene

ENSEMBL:
Gene Tree for YIPF5 (if available)
TreeFam:
Gene Tree for YIPF5 (if available)

Paralogs for YIPF5 Gene

Paralogs for YIPF5 Gene

(1) SIMAP similar genes for YIPF5 Gene using alignment to 3 proteins:

genes like me logo Genes that share paralogs with YIPF5: view

Variants for YIPF5 Gene

Sequence variations from dbSNP and Humsavar for YIPF5 Gene

SNP ID Clin Chr 05 pos Sequence Context AA Info Type
rs1000244411 -- 144,172,261(+) TTAGC(G/T)AATTT intron-variant, upstream-variant-2KB
rs1000489183 -- 144,169,551(+) GCTCC(C/T)ATCAT intron-variant, upstream-variant-2KB
rs1000490017 -- 144,165,986(+) AGACT(A/G)AATGA intron-variant
rs1000501102 -- 144,159,311(+) TACTT(C/T)ACATT utr-variant-3-prime
rs1000553616 -- 144,159,503(+) AATAA(G/T)GTAGA utr-variant-3-prime

Structural Variations from Database of Genomic Variants (DGV) for YIPF5 Gene

Variant ID Type Subtype PubMed ID
nsv1128196 CNV deletion 24896259

Variation tolerance for YIPF5 Gene

Residual Variation Intolerance Score: 66.1% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.48; 28.88% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for YIPF5 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
YIPF5

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for YIPF5 Gene

Disorders for YIPF5 Gene

MalaCards: The human disease database

(1) MalaCards diseases for YIPF5 Gene - From: DISEASES and GeneCards

Disorder Aliases PubMed IDs
pleomorphic adenoma carcinoma
  • carcinoma ex pleomorphic adenoma
- elite association - COSMIC cancer census association via MalaCards
Search YIPF5 in MalaCards View complete list of genes associated with diseases

Relevant External Links for YIPF5

Genetic Association Database (GAD)
YIPF5
Human Genome Epidemiology (HuGE) Navigator
YIPF5
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
YIPF5
genes like me logo Genes that share disorders with YIPF5: view

No data available for UniProtKB/Swiss-Prot and Genatlas for YIPF5 Gene

Publications for YIPF5 Gene

  1. The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment. (PMID: 12975309) Clark H.F. … Gray A.M. (Genome Res. 2003) 2 3 4 64
  2. Fine mapping of the CELIAC2 locus on chromosome 5q31-q33 in the Finnish and Hungarian populations. (PMID: 19845895) Koskinen L.L. … Saavalainen P. (Tissue Antigens 2009) 3 46 64
  3. YIPF5 and YIF1A recycle between the ER and the Golgi apparatus and are involved in the maintenance of the Golgi structure. (PMID: 18718466) Yoshida Y. … Nakamura N. (Exp. Cell Res. 2008) 2 3 64
  4. Immunoaffinity profiling of tyrosine phosphorylation in cancer cells. (PMID: 15592455) Rush J. … Comb M.J. (Nat. Biotechnol. 2005) 3 4 64
  5. Cloning, cellular localization, genomic organization, and tissue- specific expression of the TGFbeta1-inducible SMAP-5 gene. (PMID: 15922870) Stolle K. … Lorkowski S. (Gene 2005) 3 4 64

Products for YIPF5 Gene

Sources for YIPF5 Gene

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