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Aliases for YIPF5 Gene

Aliases for YIPF5 Gene

  • Yip1 Domain Family, Member 5 2 3
  • YIP1A 3 4 6
  • Five-Pass Transmembrane Protein Localizing In The Golgi Apparatus And The Endoplasmic Reticulum 5 3 4
  • Smooth Muscle Cell-Associated Protein 5 3 4
  • YPT-Interacting Protein 1 A 3 4
  • YIP1 Family Member 5 3 4
  • FinGER5 3 4
  • SMAP-5 3 4
  • SMAP5 3 6
  • Smooth Muscle Cell Associated Protein 5 3
  • Golgi Membrane Protein SB140 3
  • Protein YIPF5 3
  • SB140 3

External Ids for YIPF5 Gene

Previous GeneCards Identifiers for YIPF5 Gene

  • GC05M143520
  • GC05M138685

Summaries for YIPF5 Gene

GeneCards Summary for YIPF5 Gene

YIPF5 (Yip1 Domain Family, Member 5) is a Protein Coding gene. An important paralog of this gene is YIPF7.

UniProtKB/Swiss-Prot for YIPF5 Gene

  • Plays a role in transport between endoplasmic reticulum and Golgi.

Gene Wiki entry for YIPF5 Gene

No data available for Entrez Gene Summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for YIPF5 Gene

Genomics for YIPF5 Gene

Regulatory Elements for YIPF5 Gene

Genomic Location for YIPF5 Gene

Start:
144,158,159 bp from pter
End:
144,170,714 bp from pter
Size:
12,556 bases
Orientation:
Minus strand

Genomic View for YIPF5 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for YIPF5 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for YIPF5 Gene

Proteins for YIPF5 Gene

  • Protein details for YIPF5 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q969M3-YIPF5_HUMAN
    Recommended name:
    Protein YIPF5
    Protein Accession:
    Q969M3
    Secondary Accessions:
    • D3DQF5
    • Q4VSN6
    • Q53EX4
    • Q8NHE5
    • Q9H338
    • Q9H3U4

    Protein attributes for YIPF5 Gene

    Size:
    257 amino acids
    Molecular mass:
    27989 Da
    Quaternary structure:
    • Interacts with the COPII coat components Sec23 (SEC23A and/or SEC23B) and Sec24 (SEC24A and/or SEC24B). Interacts with YIF1A. May interact with RAB1A.

    Alternative splice isoforms for YIPF5 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for YIPF5 Gene

Proteomics data for YIPF5 Gene at MOPED

Post-translational modifications for YIPF5 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for YIPF5 Gene

No data available for DME Specific Peptides for YIPF5 Gene

Domains for YIPF5 Gene

Gene Families for YIPF5 Gene

HGNC:
  • YIPF :Yip1 domain family

Protein Domains for YIPF5 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for YIPF5 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q969M3

UniProtKB/Swiss-Prot:

YIPF5_HUMAN :
  • Q969M3
Family:
  • Belongs to the YIP1 family.
genes like me logo Genes that share domains with YIPF5: view

Function for YIPF5 Gene

Molecular function for YIPF5 Gene

UniProtKB/Swiss-Prot Function: Plays a role in transport between endoplasmic reticulum and Golgi.
UniProtKB/Swiss-Prot Induction: By TGFB1.

Phenotypes for YIPF5 Gene

GenomeRNAi human phenotypes for YIPF5:
genes like me logo Genes that share phenotypes with YIPF5: view

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Animal Models , Transcription Factor Targeting and HOMER Transcription for YIPF5 Gene

Localization for YIPF5 Gene

Subcellular locations from UniProtKB/Swiss-Prot for YIPF5 Gene

Endoplasmic reticulum membrane; Multi-pass membrane protein. Golgi apparatus, Golgi stack membrane; Multi-pass membrane protein. Cytoplasmic vesicle, COPII-coated vesicle. Note=Enriched at the endoplasmic reticulum exit sites. Incorporated into COPII coated vesicles.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for YIPF5 Gene COMPARTMENTS Subcellular localization image for YIPF5 gene
Compartment Confidence
endoplasmic reticulum 5
golgi apparatus 5
plasma membrane 3
cytosol 1

Gene Ontology (GO) - Cellular Components for YIPF5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005789 endoplasmic reticulum membrane IEA --
GO:0005794 Golgi apparatus --
GO:0016020 membrane --
GO:0016021 integral component of membrane IEA --
GO:0030134 ER to Golgi transport vesicle IEA --
genes like me logo Genes that share ontologies with YIPF5: view

Pathways for YIPF5 Gene

SuperPathways for YIPF5 Gene

No Data Available

Gene Ontology (GO) - Biological Process for YIPF5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0015031 protein transport IEA --
GO:0016192 vesicle-mediated transport IEA --
GO:0060628 regulation of ER to Golgi vesicle-mediated transport IEA --
genes like me logo Genes that share ontologies with YIPF5: view

No data available for Pathways by source for YIPF5 Gene

Transcripts for YIPF5 Gene

Unigene Clusters for YIPF5 Gene

Yip1 domain family, member 5:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for YIPF5 Gene

ExUns: 1a · 1b · 1c ^ 2 ^ 3a · 3b ^ 4a · 4b ^ 5a · 5b · 5c ^ 6a · 6b ^ 7a · 7b · 7c
SP1: - -
SP2: - - - -
SP3: - - - -
SP4: - -
SP5: -
SP6:

Relevant External Links for YIPF5 Gene

GeneLoc Exon Structure for
YIPF5
ECgene alternative splicing isoforms for
YIPF5

Expression for YIPF5 Gene

mRNA expression in normal human tissues for YIPF5 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for YIPF5 Gene

SOURCE GeneReport for Unigene cluster for YIPF5 Gene Hs.372050

mRNA Expression by UniProt/SwissProt for YIPF5 Gene

Q969M3-YIPF5_HUMAN
Tissue specificity: Ubiquitously expressed. Highly expressed in coronary smooth muscles.
genes like me logo Genes that share expressions with YIPF5: view

No data available for mRNA differential expression in normal tissues for YIPF5 Gene

Orthologs for YIPF5 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for YIPF5 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia YIPF5 35
  • 99.87 (n)
  • 100 (a)
YIPF5 36
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia YIPF5 35
  • 93.77 (n)
  • 97.28 (a)
YIPF5 36
  • 97 (a)
OneToOne
dog
(Canis familiaris)
Mammalia YIPF5 35
  • 94.94 (n)
  • 98.05 (a)
YIPF5 36
  • 98 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Yipf5 35
  • 88.85 (n)
  • 92.61 (a)
Yipf5 16
Yipf5 36
  • 93 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia YIPF5 36
  • 93 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia YIPF5 36
  • 91 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Yipf5 35
  • 88.59 (n)
  • 91.44 (a)
chicken
(Gallus gallus)
Aves YIPF5 35
  • 81.63 (n)
  • 90.16 (a)
YIPF5 36
  • 90 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia YIPF5 36
  • 88 (a)
OneToOne
African clawed frog
(Xenopus laevis)
Amphibia smap-5-prov 35
tropical clawed frog
(Silurana tropicalis)
Amphibia Str.6252 35
yipf5 35
  • 75.65 (n)
  • 84.77 (a)
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.2330 35
zebrafish
(Danio rerio)
Actinopterygii yipf5 35
  • 73.18 (n)
  • 82.81 (a)
yipf5 36
  • 83 (a)
OneToOne
zgc56513 35
fruit fly
(Drosophila melanogaster)
Insecta CG12404 35
  • 51.27 (n)
  • 51.41 (a)
CG12404 36
  • 42 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea F32D8.14 35
  • 53.87 (n)
  • 49.37 (a)
F32D8.14 36
  • 43 (a)
OneToMany
A. gosspyii yeast
(Ashbya gossypii)
Saccharomycetes AGOS_AAL135C 35
  • 47.76 (n)
  • 44.16 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes YIP1 35
  • 48.84 (n)
  • 43.6 (a)
YIP1 36
  • 32 (a)
OneToMany
YIP1 38
K. lactis yeast
(Kluyveromyces lactis)
Saccharomycetes KLLA0F15015g 35
  • 48.72 (n)
  • 44.97 (a)
thale cress
(Arabidopsis thaliana)
eudicotyledons AT2G36300 35
  • 47.53 (n)
  • 37.8 (a)
rice
(Oryza sativa)
Liliopsida Os03g0289200 35
  • 45.1 (n)
  • 40.69 (a)
bread mold
(Neurospora crassa)
Ascomycetes NCU05514 35
  • 47.46 (n)
  • 45.76 (a)
fission yeast
(Schizosaccharomyces pombe)
Schizosaccharomycetes SPCC61.04c 35
  • 51.21 (n)
  • 42.73 (a)
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.3073 35
sea squirt
(Ciona savignyi)
Ascidiacea CSA.977 36
  • 51 (a)
OneToMany
Species with no ortholog for YIPF5:
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for YIPF5 Gene

ENSEMBL:
Gene Tree for YIPF5 (if available)
TreeFam:
Gene Tree for YIPF5 (if available)

Paralogs for YIPF5 Gene

Paralogs for YIPF5 Gene

Selected SIMAP similar genes for YIPF5 Gene using alignment to 3 proteins:

genes like me logo Genes that share paralogs with YIPF5: view

Variants for YIPF5 Gene

Sequence variations from dbSNP and Humsavar for YIPF5 Gene

SNP ID Clin Chr 05 pos Sequence Context AA Info Type MAF
rs1043292 -- 144,159,578(-) CTCCA(A/G)AAATT utr-variant-3-prime
rs1137133 -- 144,160,008(-) CAAGA(A/C)GGCCG utr-variant-3-prime
rs1833501 -- 144,166,902(+) TAATA(C/T)GATGA intron-variant
rs4122252 -- 144,166,854(+) TGAAA(C/T)TGACT intron-variant
rs4263530 -- 144,162,943(+) GTGAG(C/G)AACAG intron-variant

Structural Variations from Database of Genomic Variants (DGV) for YIPF5 Gene

Variant ID Type Subtype PubMed ID
nsv882997 CNV Gain 21882294

Relevant External Links for YIPF5 Gene

HapMap Linkage Disequilibrium report
YIPF5

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for YIPF5 Gene

Disorders for YIPF5 Gene

(1) University of Copenhagen DISEASES for YIPF5 Gene

Relevant External Links for YIPF5

Genetic Association Database (GAD)
YIPF5
Human Genome Epidemiology (HuGE) Navigator
YIPF5
genes like me logo Genes that share disorders with YIPF5: view

No data available for UniProtKB/Swiss-Prot for YIPF5 Gene

Publications for YIPF5 Gene

  1. The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment. (PMID: 12975309) Clark H.F. … Gray A.M. (Genome Res. 2003) 2 3 4
  2. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4
  3. A membrane protein enriched in endoplasmic reticulum exit sites interacts with COPII. (PMID: 11489904) Tang B.L. … Hong W. (J. Biol. Chem. 2001) 3 4
  4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4
  5. Large-scale cDNA transfection screening for genes related to cancer development and progression. (PMID: 15498874) Wan D. … Gu J. (Proc. Natl. Acad. Sci. U.S.A. 2004) 3 4

Products for YIPF5 Gene

Sources for YIPF5 Gene

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