YIPF5 Gene
protein-coding GIFtS: 49
GCID: GC05M143520
|
|
Yip1 domain family, member 5
| |
Aliases
for YIPF5 gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| Yip1 Domain Family, Member 51 2 | | YPT-Interacting Protein 1 A2 3 | | SMAP-51 2 3 | | SMAP52 5 | | YIP1A2 3 5 | | SB1402 | | FinGER51 2 | | Golgi Membrane Protein SB1402 | | Five-Pass Transmembrane Protein Localizing In The Golgi Apparatus And TheEndoplasmic Reticulum 52 3 | | Protein YIPF52 | | Smooth Muscle Cell-Associated Protein 52 3 | | Smooth Muscle Cell Associated Protein 52 | | YIP1 Family Member 52 3 | | FINGER53 |
Export aliases for YIPF5 gene to outside databasesPrevious GC identifer: GC05M138685 |
Summaries
for YIPF5 gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
UniProtKB/Swiss-Prot: YIPF5_HUMAN, Q969M3Function: Plays a role in transport between endoplasmic reticulum and Golgi
Gene Wiki entry for YIPF5
|
Genomic Views
for YIPF5 gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000005.9 NC_018916.1 NT_029289.11
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the YIPF5 gene promoter:
GR RP58 AML1a GR-beta Nkx2-5 FOXO3b GATA-1 SRY FOXO3a GR-alpha
Other transcription factors
Search SABiosciences Chromatin IP Primers for YIPF5
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat YIPF5 |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 5q31.3 Ensembl cytogenetic band: 5q31.3 HGNC cytogenetic band: 5q31.3YIPF5 Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 5 GeneLoc Exon Structure GeneLoc location for GC05M143520: view genomic region
(about GC identifiers)
Start:
|
143,537,723 bp from pter |
End:
|
143,550,278 bp from pter |
Size:
|
12,556 bases |
Orientation:
|
minus strand |
|
Proteins
for YIPF5 gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: YIPF5_HUMAN, Q969M3 (See
protein sequence)Recommended Name: Protein YIPF5 Size: 257 amino acids; 27989 Da
Subunit: Interacts with the COPII coat components Sec23 (SEC23A and/or SEC23B) and Sec24 (SEC24A and/or SEC24B).Interacts with YIF1A. May interact with RAB1A
Subcellular location: Endoplasmic reticulum membrane; Multi-pass membrane protein. Golgi apparatus, Golgi stackmembrane; Multi-pass membrane protein. Cytoplasmic vesicle, COPII-coated vesicle. Note=Enriched at the endoplasmicreticulum exit sites. Incorporated into COPII coated vesicles
Secondary accessions: D3DQF5 Q4VSN6 Q53EX4 Q8NHE5 Q9H338 Q9H3U4Alternative splicing: 3 isoforms: Q969M3-1 Q969M3-2 Q969M3-3 Explore the universe of human proteins at neXtProt for YIPF5: NX_Q969M3
Post-translational modifications:
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_Q969M3
YIPF5 Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins (3 alternative transcripts):
NP_001020118.1 NP_001258661.1 NP_110426.4
ENSEMBL proteins: ENSP00000274496 ENSP00000397704 ENSP00000425422 ENSP00000429777 ENSP00000428715
Human Recombinant Protein Products:
Gene Ontology (GO): 5/6 cellular component terms (GO ID links to tree view) (see all 6): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0005789 | endoplasmic reticulum membrane |
IEA | -- | | GO:0016021 | integral to membrane |
IEA | -- | | GO:0030134 | ER to Golgi transport vesicle |
IEA | -- | | GO:0032580 | Golgi cisterna membrane |
IEA | -- | | GO:0042175 | nuclear outer membrane-endoplasmic reticulum membrane network |
-- | -- |
YIPF5 for ontologies About GeneDecksing
YIPF5 Antibody Products:
Assay Products for YIPF5: |
Protein
Domains /
Families
for YIPF5 gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
YIPF5 for domains About GeneDecksing
1 InterPro domain/family:Graphical View of Domain Structure for InterPro Entry Q969M3ProtoNet protein and cluster: Q969M3 UniProtKB/Swiss-Prot: YIPF5_HUMAN, Q969M3Similarity: Belongs to the YIP1 family |
Function
for YIPF5 gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Function Summary:
UniProtKB/Swiss-Prot: YIPF5_HUMAN, Q969M3Function: Plays a role in transport between endoplasmic reticulum and GolgiInduction: By TGFB1
Clone
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OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for YIPF5 (see all 2)
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
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In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for YIPF5 |
2 GenomeRNAi human phenotypes for YIPF5:
|
Pathways & Interactions
for YIPF5 gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Interactions:
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for YIPF5
STRING Interaction
Network Preview (showing 5 interactants - click image to see 14)
5/32 Interacting proteins for YIPF5 (Q969M33 ENSP000002744964) via UniProtKB, MINT, STRING, and/or I2D (see all 32)About this table
Gene Ontology (GO): 3 biological process terms (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0015031 | protein transport |
IEA | -- | | GO:0016192 | vesicle-mediated transport |
IEA | -- | | GO:0060628 | regulation of ER to Golgi vesicle-mediated transport |
IEA | -- |
YIPF5 for ontologies About GeneDecksing
|
Drugs & Compounds
for YIPF5 gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
 Browse Tocris compounds for YIPF5
Search CenterWatch for drugs/clinical trials and news about YIPF5
|
Transcripts
for YIPF5 gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for YIPF5 gene (3 alternative transcripts): NM_001024947.3 NM_001271732.1 NM_030799.8 Unigene Cluster for YIPF5: Yip1 domain family, member 5 Hs.372050 [show with all ESTs]Unigene Representative Sequence: NM_0010249477 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000274496(uc003lnk.4 uc003lnl.4 uc010jgl.3) ENST00000448443
ENST00000513112 ENST00000519064 ENST00000503333 ENST00000522203 ENST00000508754
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for YIPF5 (see all 4)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for YIPF5 (see all 2)
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector (see all 2): YIPF5 (NM_001024947) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for YIPF5 | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat YIPF5 |
Additional cDNA sequence: AB014733.1 AF140225.1 AF318329.1 AK054576.1 AK124065.1 AK223515.1 AK307251.1 AY358863.1 AY640925.1 AY640926.1 AY640927.1 AY640928.1 AY640929.1 AY640934.1 BC007829.2 BC014253.2 BC024737.1 BX647859.1 CR749463.1 11 DOTS entries: DT.211535 DT.101982836 DT.120800667 DT.99975828 DT.91769323 DT.100814197 DT.91769322 DT.120800631 DT.100028545 DT.120800671 DT.120800672 24/262 AceView cDNA sequences (see all 262): CB120933 BP336090 AA431454 CB106516 CB136518 AI335907 AL542272 BQ949791 AI925556 C21544 BU949237 CB131246 BQ646289 AA373289 AA535949 BF727025 BQ716925 BQ650570 BQ652735 BI038297 AU279904 CA389327 AW069481 AY358863
GeneLoc Exon Structure
5/6 Alternative Splicing Database (ASD) splice patterns (SP) for YIPF5 (see all 6) About this scheme
| ExUns: | 1a | · | 1b | · | 1c | ^ | 2 | ^ | 3a | · | 3b | ^ | 4a | · | 4b | ^ | 5a | · | 5b | · | 5c | ^ | 6a | · | 6b | ^ | 7a | · | 7b | · | 7c |
|---|
|
| SP1: | | | | | | | - | | | | | | | | | | | | | | - | | | | | | | | | | | | |
| SP2: | | | | | | | - | | | | - | | - | | | | | | | | - | | | | | | | | | | | | |
| SP3: | | | | | | | - | | - | | - | | | | | | | | | | - | | | | | | | | | | | | |
| SP4: | | | | | | | - | | | | | | | | | | | | | | - | | | | | | | | | | | | |
| SP5: | | | | | | | - | | | | | | | | | | | | | | | | | | | | | | | | | |
ECgene alternative splicing isoforms for YIPF5
|
Expression
for YIPF5 gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| YIPF5 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: CAGAGTTGTA
About this image
See YIPF5 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for YIPF5
SOURCE GeneReport for Unigene cluster: Hs.372050
UniProtKB/Swiss-Prot: YIPF5_HUMAN, Q969M3Tissue specificity: Ubiquitously expressed. Highly expressed in coronary smooth muscles
SABiosciences Custom PCR Arrays for YIPF5
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for YIPF5
Browse OriGene validated miRNA SYBR primer pairs
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Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for YIPF5 |
Orthologs
for YIPF5 gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of eukaryotes.
Orthologs for YIPF5 gene from 10/35 species (see all 35) About this table
ENSEMBL Gene Tree for YIPF5 (if available)
TreeFam Gene Tree for YIPF5 (if available) |
Paralogs
for YIPF5 gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| Paralogs for YIPF5 gene
- YIPF72
1 SIMAP similar gene for YIPF5 using alignment to 3 protein entries: YIPF5_HUMAN (see all proteins):YIPF7
YIPF5 for paralogs About GeneDecksing
|
Genomic Variants
for YIPF5 gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 5 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for YIPF5 (143537723 - 143550278 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV) variations for YIPF5: -- | SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing YIPF5 |
|
Disorders
/ Diseases
for YIPF5 gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
YIPF5 for disorders About GeneDecksing
OMIM gene information: 611483
OMIM disorders: --
4  diseases for YIPF5: About MalaCardscarpal tunnel syndrome perineurioma stomatitis malaria
1 disease from the University of Copenhagen DISEASES database for YIPF5:Stomatitis Human Genome Epidemiology (HuGE) Navigator: YIPF5 (1 document)
Export disorders for YIPF5 gene to outside databases
|
Publications
for YIPF5 gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for YIPF5 gene, integrated from 9 sources (see all 20):
(articles sorted by number of sources associating them with YIPF5) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment. (PubMed id 12975309)1, 2, 3 Clark H.F.... Gray A.M. (2003)
- YIPF5 and YIF1A recycle between the ER and the Golgi apparatus and are involved in the maintenance of the Golgi structure. (PubMed id 18718466)1, 3 Yoshida Y....Nakamura N. (2008)
- Human Yip1A specifies the localization of Yif1 to the Golgi apparatus. (PubMed id 15990086)1, 2 Jin C.... Yao X. (2005)
- Immunoaffinity profiling of tyrosine phosphorylation in cancer cells. (PubMed id 15592455)1, 2 Rush J.... Comb M.J. (2005)
- Cloning, cellular localization, genomic organization, and tissue- specific expression of the TGFbeta1-inducible SMAP-5 gene. (PubMed id 15922870)1, 2 Stolle K.... Lorkowski S. (2005)
- Genetic analysis of yeast Yip1p function reveals a requirement for Golgi-localized rab proteins and rab-Guanine nucleotide dissociation inhibitor. (PubMed id 15611160)1, 2 Chen C.Z....Collins R.N. (2004)
- Large-scale cDNA transfection screening for genes related to cancer development and progression. (PubMed id 15498874)1, 2 Wan D....Gu J. (2004)
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
- Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
- A membrane protein enriched in endoplasmic reticulum exit sites interacts with COPII. (PubMed id 11489904)1, 2 Tang B.L....Hong W. (2001)
|
External Searches for YIPF5 gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
|
Genome Databases showing YIPF5 gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing YIPF5 gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing YIPF5 gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
| Name | Description |
| PharmGKB entry for YIPF5 | Pharmacogenomics, SNPs, Pathways |
|
| | |
About This Section
| Patent Information for YIPF5 gene:
Search GeneIP for patents involving YIPF5
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for YIPF5 gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
About This Section
|
 | |
 | |
 |
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| | | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for YIPF5 |
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