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Aliases & Descriptions for YIPF5
(According to
1 HGNC ,
2 Entrez Gene ,
3 UniProtKB/Swiss-Prot ,
4 UniProtKB/TrEMBL , 5 OMIM , 6 GeneLoc
, and/or 7 Ensembl ,
8 miRBase )About This Section
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Aliases DKFZp313L2216 2 FINGER5 3 FinGER5 1 , 2 SB140 2 SMAP-5 1 , 2 , 3 SMAP5 2 , 5 YIP1A 2 , 3 , 5
Descriptions Five-pass transmembrane protein localizing in the Golgi apparatus and the endoplasmic reticulum 5 3 Smooth muscle cell-associated protein 5 3 YIP1 family member 5 3 YPT-interacting protein 1 A 3 Yip1 domain family, member 5 2 golgi membrane protein SB140 2 smooth muscle cell associated protein 5 2
Search outside databases for aliases for YIPF5 gene
Summaries for YIPF5 (According to Entrez Gene ,
Wikipedia's
Gene Wiki ,
UniProtKB/Swiss-Prot ,
and/or
UniProtKB/TrEMBL )
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UniProtKB/Swiss-Prot: YIPF5_HUMAN, Q969M3 Function : Plays a role in transport between endoplasmic reticulum and Golgi
Gene Wiki entry for YIPF5
Genomic Location for YIPF5
(According to
GeneLoc and/or
HGNC , and/or
Entrez Gene (NCBI build 36) ,
and/or miRBase ,
Genomic Views according to
UCSC and
Ensembl ,
Transcription factor binding sites according to
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Genomic View : UCSC Golden Path with GeneCards custom track Transcription factor binding sites upstream to the YIPF5 gene Entrez Gene cytogenetic band: 5q32 Ensembl cytogenetic band: 5q32 HGNC cytogenetic band: 5q31.3 YIPF5 Gene in genomic location: bands according to Ensembl, locations according to
(and/or Entrez Gene and/or Ensembl if different) GeneLoc gene densities for chromosome 5 GeneLoc Exon Structure
GeneLoc location for GC05M143520:
(about GC identifiers )
Start:
143,517,919 bp from pter
End:
143,530,409 bp from pter
Size:
12,491 bases
Orientation:
minus strand
RefSeq DNA sequence: NC_000005.8 NT_029289.10 Proteins for YIPF5
(According to
1 UniProtKB ,
and/or Ensembl ,
Phosphorylation sites according to 2 Phosphosite ,
RefSeq according to NCBI ,
PDB rendering according to OCA and/or Proteopedia ,
Recombinant Proteins
from Invitrogen ,
Millipore ,
Sigma-Aldrich ,
R&D Systems ,
Enzo Life Sciences ,
Abnova ,
OriGene and/or,
Abcam ,
Biochemical Assays by
Invitrogen ,
Millipore ,
R&D Systems ,
Cell Signaling Technology , and/or
Enzo Life Sciences ,
Ontologies according to Gene
Ontology Consortium 01 Apr 2009 and
Entrez Gene ,
Antibodies by Invitrogen ,
Millipore ,
Sigma-Aldrich ,
R&D Systems ,
Cell Signaling Technology ,
Abcam ,
Abnova , and/or
Novus Biologicals )
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UniProtKB/Swiss-Prot: YIPF5_HUMAN, Q969M3 (See
protein sequence )Recommended Name: Protein YIPF5 Size : 257 amino acids; 27989 Da
Subunit : Interacts with the COPII coat components Sec23 (SEC23A and/or SEC23B) and Sec24 (SEC24Aand/or SEC24B). Interacts with YIF1A. May interact with RAB1A
Subcellular location : Endoplasmic reticulum membrane; Multi-pass membrane protein. Golgi apparatus,Golgi stack membrane; Multi-pass membrane protein. Cytoplasmic vesicle, COPII-coated vesicle.Note=Enriched at the endoplasmic reticulum exit sites. Incorporated into COPII coated vesicles
Secondary accessions : Q4VSN6 Q53EX4 Q8NHE5 Q9H338 Q9H3U4Alternative splicing : 3 isoforms : Q969M3-1 Q969M3-2 Q969M3-3
Post-translational modifications:
View phosphorylation sites using PhosphoSite 2
REFSEQ proteins (2 alternative transcripts):
NP_001020118.1 NP_110426.4 ENSEMBL proteins: ENSP00000274496 ENSP00000367224 Human Recombinant Proteins Browse Origene for full length recombinant human proteins expressed in human HEK293 cells 5/6 Gene Ontology (GO) cellular component terms (links to tree view) (see all 6
):
About this table Antibodies for YIPF5: Assays for YIPF5:
Protein
Domains/ Families for YIPF5(According to InterPro , ProtoNet ,
UniProtKB , and/or BLOCKS ,
Sets of similar genes according to GeneDecks )
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Graphical View of Domain Structure for InterPro Entry Q969M3 ProtoNet protein and cluster: Q969M3
UniProtKB/Swiss-Prot: YIPF5_HUMAN, Q969M3 Similarity : Belongs to the YIP1 family
Gene Function for YIPF5
(According to MGI Jun 06 2009, UniProtKB ,
IUBMB ,and/or Genatlas ,
shRNA from
OriGene ,
Sigma-Aldrich , RNAi from
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RNAi Products ,
Clones , and
Q-PCR Products
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Millipore ,
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SYBR primers from OriGene ,
Cell-based Assays from Millipore ,
Ontologies according to Gene Ontology Consortium 01 Apr 2009 via
Entrez Gene .)
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               OriGene 29mer shRNA kit in GFP-retroviral vectors (see all 2 ): NM_030799 Applied Biosystems Silencer ® siRNAs for YIPF5 Sigma-Aldrich siRNA for YIPF5 Sigma-Aldrich shRNA for YIPF5 Explore Sigma-Aldrich super-pooled esiRNAs                OriGene GFP tagged cDNA clones in CMV expression vector (see all 2 ): NM_001024947                                  Myc/DDK tagged cDNA clones in CMV expression vector (see all 2 ): NM_001024947                                  untagged cDNA clones in CMV expression vector (see all 2 ): NM_001024947  Primers: Browse
Quantitative PCR Central at Invitrogen for Q-PCR LUX™ Primers               OriGene genome-wide validated SYBR primer pairs: NM_030799 UniProtKB/Swiss-Prot: YIPF5_HUMAN, Q969M3 Function : Plays a role in transport between endoplasmic reticulum and GolgiInduction : By TGFB1
Pathways & Interactions for YIPF5
(Pathways according to Invitrogen
(maps by GeneGo ),
Millipore ,
Cell Signaling Technology ,
Sigma-Aldrich ,
KEGG
and/or UniProtKB ,
Sets of similar genes according to GeneDecks ,
Proteins Network according to
SABiosciences ,
Interactions according to 1 UniProtKB ,
2 MINT , and/or
3 STRING ,
with links to IntAct and
Ensembl ,
Ontologies according to Gene Ontology Consortium 01 Apr 2009 via
Entrez Gene .)
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1 Interacting protein for YIPF5 (ENSP00000367224 3 ) via UniProtKB, MINT, and/or STRING About this table 2 Gene Ontology (GO) biological process terms (links to tree view) :
GO ID Qualified GO term Evidence PubMed IDs GO:0015031 protein transport
IEA -- GO:0016192 vesicle-mediated transport
IEA --
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Drugs & Compounds for YIPF5 (Chemical Compounds according to UniProtKB , Enzo Life Sciences ,
Sigma-Aldrich , Tocris Bioscience , and/or
Novoseek and Drugs according to
Enzo Life Sciences and/or
PharmGKB )
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Transcripts for YIPF5(GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 219 Homo sapiens; Jun 2 2009) or GenBank , RefSeq according to Entrez Gene ,
DOTS (version 10), and/or
AceView ,
non coding RNAs according to
RNAdb ,
ESTs according to GeneTide ,
exon structure from GeneLoc ,
alternative splicing isoforms according to ASD and/or
ECgene ,
RNAi Products from Invitrogen ,
Millipore , and/or
Abnova ,
siRNAs from Applied Biosystems ,
Sigma-Aldrich ,
shRNA from
Sigma-Aldrich ,
OriGene ,
Tagged/untagged cDNA clones from
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               OriGene 29mer shRNA kit in GFP-retroviral vectors (see all 2 ): NM_030799 Sigma-Aldrich siRNA for YIPF5 Sigma-Aldrich shRNA for YIPF5 Explore Sigma-Aldrich super-pooled esiRNAs
Applied Biosystems Silencer ® siRNAs: NM_001024947 NM_030799
REFSEQ mRNAs for YIPF5 gene (2 alternative transcripts): NM_001024947.2 NM_030799.7
Applied Biosystems TaqMan ® Gene Expression Assays: NM_001024947 NM_030799
               OriGene GFP tagged cDNA clones in CMV expression vector (see all 2 ): NM_001024947                                  Myc/DDK tagged cDNA clones in CMV expression vector (see all 2 ): NM_001024947                                  untagged cDNA clones in CMV expression vector (see all 2 ): NM_001024947  
Additional cDNA sequence: AB014733.1 AF140225.1 AF318329.1 AK054576.1 AK124065.1 AK223515.1 AK307251.1 AY358863.1 AY640925.1 AY640926.1 AY640927.1 AY640928.1 AY640929.1 AY640934.1 BC007829.2 BC014253.2 BC024737.1 BX647859.1 CR749463.1
11 DOTS entries : DT.211535 DT.101982836 DT.120800667 DT.99975828 DT.91769323 DT.100814197 DT.91769322 DT.120800631 DT.100028545 DT.120800671 DT.120800672
24/262 AceView cDNA sequences (see all 262
):BM310652 BQ009703 AA431454 BQ652735 BF727025 AA373289 AI925556 AW069100 NM_030799 CB150061 CB106516 BF793125 BM310949 AW069481 BI038297 BQ710172 CB120933 BP336090 BQ932724 AL542272 BM562472 CD365961 C21544 CD678669
highest scoring ESTs for YIPF5 :AA132208 AA169752 AA171435 AA305800 AA356684 AA375715 AF318329 AK054576 AK124065 AL599810
Unigene Cluster for YIPF5: Yip1 domain family, member 5 Hs.372050 [show with all ESTs ] Unigene Representative Sequence: NM_001024947 GeneLoc Exon Structure 5/6 Alternative Splicing Database (ASD) splice patterns (SP) for YIPF5 (see all 6
) ExUns: 1a · 1b · 1c ^ 2 ^ 3a · 3b ^ 4a · 4b ^ 5a · 5b · 5c ^ 6a · 6b ^ 7a · 7b · 7c SP1 :       -               -             SP2 :       -     -   -         -             SP3 :       -   -   -           -             SP4 :       -               -             SP5 :       -                          
About this scheme ECgene alternative splicing isoforms for YIPF5 2 Ensembl transcripts including schematic representations : ENST00000274496
ENST00000377986
Expression for YIPF5
(Experimental results according to
1 GeneNote
and GNF BioGPS ,
probe sets-to-genes annotations according to
2 GeneAnnot ,
3 GeneTide ,
Sets of similar genes according to GeneDecks ,
Electronic Northern calculations according to data from
UniGene (Build 219 Homo sapiens),
SAGE tags according to
CGAP ,
plus additional links to
SOURCE , and/or
GNF
BioGPS , and/or
EXPOLDB , and/or
UniProtKB ,
Expression Assays from
Applied Biosystems
)
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YIPF5 expression in normal and diseased human tissues Applied Biosystems TaqMan ® Gene Expression Assays for YIPF5 1 / 2 / 3
13 probe-sets matching YIPF5 gene Data from
(Publications) and GNF BioGPS About these images About these images CGAP SAGE TAG: CAGAGTTGTASOURCE GeneReport for Unigene cluster: Hs.372050 UniProtKB/Swiss-Prot: YIPF5_HUMAN, Q969M3 Tissue specificity : Ubiquitously expressed. Highly expressed in coronary smooth muscles
Orthologs for YIPF5
(Orthologs according to
1,2 HomoloGene (2 older version, for species not in 1 newer version),
3 euGenes ,
4 SGD
and/or
5 MGI Jun 06 2009,
with possible further links to
Flybase
and/or
WormBase ,
Gene Trees according to Ensembl )
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Orthologs for YIPF5 gene from 5/21 species (see all 21
)
About this table Species with no ortholog for YIPF5 ENSEMBL Gene Tree for YIPF5 Paralogs for YIPF5 (Paralogs according to 1 HomoloGene and 2 Ensembl , Pseudogenes according to 3 Pseudogene.org )About This Section
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Paralogs for YIPF5 gene YIPF7 2
SNPs/Variants for YIPF5 (According to the
1 NCBI SNP Database ,
2 Ensembl ,
3 PupaSUITE , and
UniProtKB ,
Linkage Disequilibrium by HapMap ,
Genotyping Reagents from
Applied Biosystems )
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HapMap Linkage Disequilibrium images for YIPF5 (up to first 250kb)
Disorders & Mutations for YIPF5
(in which this Gene is Involved, According to
OMIM, UniProtKB ,
PharmGKB ,
Genatlas , GeneTests ,
Blood group antigen gene mutations by BGMUT ,
HGMD, GAD ,
HuGE Navigator ,
BCGD ,
and/or TGDB .)
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OMIM: 611483
Medical News for YIPF5 (Possibly Related Articles in
Doctor's Guide )
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--
Publications for YIPF5 (in
PubMed .
Associations of this gene to articles via
1 Novoseek ,
2 HGNC ,
3 Entrez Gene ,
4 UniProtKB/Swiss-Prot ,
5 UniProtKB/TrEMBL ,
6 GAD , and/or
7 PharmGKB )
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10/15 PubMed articles for YIPF5 gene (see all 15
): The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment. (PubMed id 12975309) 2, 3, 4 Clark H.F....Gray A. (2003) YIPF5 and YIF1A recycle between the ER and the Golgi apparatus and are involved in the maintenance of the Golgi structure. (PubMed id 18718466) 2, 3 Yoshida Y....Nakamura N. (2008) Immunoaffinity profiling of tyrosine phosphorylation in cancer cells. (PubMed id 15592455) 3, 4 Rush J.... Comb M.J. (2005) Human Yip1A specifies the localization of Yif1 to the Golgi apparatus. (PubMed id 15990086) 3, 4 Jin C.... Yao X. (2005) Cloning, cellular localization, genomic organization, and tissue- specific expression of the TGFbeta1-inducible SMAP-5 gene. (PubMed id 15922870) 3, 4 Stolle K.... Lorkowski S. (2005) Genetic analysis of yeast Yip1p function reveals a requirement for Golgi-localized rab proteins and rab-Guanine nucleotide dissociation inhibitor. (PubMed id 15611160) 3, 4 Chen C.Z....Collins R.N. (2004) The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334) 3, 4 Gerhard D.S....Malek J. (2004) Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039) 3, 4 Ota T....Sugano S. (2004) Large-scale cDNA transfection screening for genes related to cancer development and progression. (PubMed id 15498874) 3, 4 Wan D....Gu J. (2004) A membrane protein enriched in endoplasmic reticulum exit sites interacts with COPII. (PubMed id 11489904) 3, 4 Tang B.L....Hong W. (2001)
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Genome Databases showing YIPF5
(According to
Entrez Gene ,
HGNC ,
AceView ,
euGenes ,
Ensembl ,
miRBase ,
ECgene ,
and/or
H-InvDB )
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Other Databases showing YIPF5
(According to HUGE )
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Specialized Databases showing YIPF5 (According to ATLAS , HORDE , IMGT , MTDB, LEIDEN , UniProtKB/Swiss-Prot , and/or UniProtKB/TrEMBL ,Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot )About This Section
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-- Services for YIPF5 (Reagents available from Applied Biosystems , Antibodies and assays by Cell
Signaling Technology , Abcam , Novus Biologicals ,Sigma-Aldrich , R&D Systems , Millipore , Abnova , and/or Invitrogen , Clones available from OriGene ,and/or Invitrogen , Drugs and/or compounds by Sigma-Aldrich , Enzo Life Sciences , and/or Tocris Bioscience )About This Section
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