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Aliases for YIPF4 Gene

Aliases for YIPF4 Gene

  • Yip1 Domain Family Member 4 2 3 5
  • YIP1 Family Member 4 3 4
  • Putative Protein Product Of Nbla11189 3
  • Yip1 Domain Family, Member 4 2
  • Protein YIPF4 3
  • Nbla11189 3
  • FinGER4 3

External Ids for YIPF4 Gene

Previous GeneCards Identifiers for YIPF4 Gene

  • GC02P032416
  • GC02P032356
  • GC02P032502

Summaries for YIPF4 Gene

GeneCards Summary for YIPF4 Gene

YIPF4 (Yip1 Domain Family Member 4) is a Protein Coding gene.

UniProtKB/Swiss-Prot for YIPF4 Gene

  • Involved in the maintenance of the Golgi structure.

Gene Wiki entry for YIPF4 Gene

No data available for Entrez Gene Summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for YIPF4 Gene

Genomics for YIPF4 Gene

Regulatory Elements for YIPF4 Gene

Enhancers for YIPF4 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
- Elite enhancer/Elite enhancer-gene association

Enhancers around YIPF4 on UCSC Golden Path with GeneCards custom track

Promoters for YIPF4 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around YIPF4 on UCSC Golden Path with GeneCards custom track

Genomic Location for YIPF4 Gene

32,277,889 bp from pter
32,316,594 bp from pter
38,706 bases
Plus strand

Genomic View for YIPF4 Gene

Genes around YIPF4 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
YIPF4 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for YIPF4 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for YIPF4 Gene

Proteins for YIPF4 Gene

  • Protein details for YIPF4 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Protein YIPF4
    Protein Accession:

    Protein attributes for YIPF4 Gene

    244 amino acids
    Molecular mass:
    27083 Da
    Quaternary structure:
    • Interacts with YIPF3.

neXtProt entry for YIPF4 Gene

Post-translational modifications for YIPF4 Gene

  • Ubiquitination at Lys 47
  • Modification sites at PhosphoSitePlus

Other Protein References for YIPF4 Gene

ENSEMBL proteins:
REFSEQ proteins:

Antibody Products

  • Abcam antibodies for YIPF4

No data available for DME Specific Peptides for YIPF4 Gene

Domains & Families for YIPF4 Gene

Gene Families for YIPF4 Gene

Protein Domains for YIPF4 Gene


Suggested Antigen Peptide Sequences for YIPF4 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the YIP1 family.
  • Belongs to the YIP1 family.
genes like me logo Genes that share domains with YIPF4: view

Function for YIPF4 Gene

Molecular function for YIPF4 Gene

UniProtKB/Swiss-Prot Function:
Involved in the maintenance of the Golgi structure.

Gene Ontology (GO) - Molecular Function for YIPF4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 16189514
genes like me logo Genes that share ontologies with YIPF4: view

Phenotypes for YIPF4 Gene

genes like me logo Genes that share phenotypes with YIPF4: view

Animal Model Products

  • Taconic Biosciences Mouse Models for YIPF4

CRISPR Products

miRNA for YIPF4 Gene

miRTarBase miRNAs that target YIPF4

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for YIPF4 Gene

Localization for YIPF4 Gene

Subcellular locations from UniProtKB/Swiss-Prot for YIPF4 Gene

Golgi apparatus, cis-Golgi network membrane; Multi-pass membrane protein.

Subcellular locations from

Jensen Localization Image for YIPF4 Gene COMPARTMENTS Subcellular localization image for YIPF4 gene
Compartment Confidence
endoplasmic reticulum 5
golgi apparatus 5
plasma membrane 5
nucleus 1

Gene Ontology (GO) - Cellular Components for YIPF4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005783 endoplasmic reticulum IDA --
GO:0005794 Golgi apparatus IDA --
GO:0005886 plasma membrane IDA --
GO:0016021 integral component of membrane IEA --
GO:0043231 intracellular membrane-bounded organelle IDA --
genes like me logo Genes that share ontologies with YIPF4: view

Pathways & Interactions for YIPF4 Gene

SuperPathways for YIPF4 Gene

No Data Available

Gene Ontology (GO) - Biological Process for YIPF4 Gene


No data available for Pathways by source and SIGNOR curated interactions for YIPF4 Gene

Drugs & Compounds for YIPF4 Gene

No Compound Related Data Available

Transcripts for YIPF4 Gene

Unigene Clusters for YIPF4 Gene

Yip1 domain family, member 4:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for YIPF4 Gene

ExUns: 1a · 1b · 1c ^ 2 ^ 3a · 3b ^ 4 ^ 5a · 5b ^ 6a · 6b · 6c
SP2: -
SP3: - - -
SP4: -
SP5: - -

Relevant External Links for YIPF4 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for YIPF4 Gene

mRNA expression in normal human tissues for YIPF4 Gene

Protein differential expression in normal tissues from HIPED for YIPF4 Gene

This gene is overexpressed in Bone (20.5), Fetal testis (11.2), and Oral epithelium (6.2).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for YIPF4 Gene

NURSA nuclear receptor signaling pathways regulating expression of YIPF4 Gene:


SOURCE GeneReport for Unigene cluster for YIPF4 Gene:

genes like me logo Genes that share expression patterns with YIPF4: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein tissue co-expression partners and mRNA Expression by UniProt/SwissProt for YIPF4 Gene

Orthologs for YIPF4 Gene

This gene was present in the common ancestor of animals.

Orthologs for YIPF4 Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia YIPF4 34
  • 96.11 (n)
  • 98.33 (a)
YIPF4 35
  • 93 (a)
(Canis familiaris)
Mammalia YIPF4 34
  • 95.36 (n)
  • 98.77 (a)
YIPF4 35
  • 99 (a)
(Mus musculus)
Mammalia Yipf4 34
  • 93.25 (n)
  • 97.84 (a)
Yipf4 16
Yipf4 35
  • 97 (a)
(Pan troglodytes)
Mammalia YIPF4 34
  • 99.73 (n)
  • 100 (a)
YIPF4 35
  • 100 (a)
(Rattus norvegicus)
Mammalia Yipf4 34
  • 93.1 (n)
  • 97.84 (a)
(Monodelphis domestica)
Mammalia YIPF4 35
  • 95 (a)
(Ornithorhynchus anatinus)
Mammalia YIPF4 35
  • 97 (a)
(Gallus gallus)
Aves YIPF4 34
  • 85.06 (n)
  • 96.98 (a)
YIPF4 35
  • 93 (a)
(Anolis carolinensis)
Reptilia YIPF4 35
  • 76 (a)
African clawed frog
(Xenopus laevis)
Amphibia Xl.16552 34
tropical clawed frog
(Silurana tropicalis)
Amphibia Str.13074 34
(Danio rerio)
Actinopterygii Dr.6134 34
yipf4 34
  • 75 (n)
  • 87.93 (a)
yipf4 35
  • 86 (a)
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.3395 34
(Caenorhabditis elegans)
Secernentea CELE_Y60A3A.19 34
  • 59.01 (n)
  • 53.15 (a)
T08D2.6 35
  • 52 (a)
Y60A3A.19 35
  • 46 (a)
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.1954 34
sea squirt
(Ciona savignyi)
Ascidiacea CSA.6512 35
  • 56 (a)
Species where no ortholog for YIPF4 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for YIPF4 Gene

Gene Tree for YIPF4 (if available)
Gene Tree for YIPF4 (if available)

Paralogs for YIPF4 Gene

No data available for Paralogs for YIPF4 Gene

Variants for YIPF4 Gene

Sequence variations from dbSNP and Humsavar for YIPF4 Gene

SNP ID Clin Chr 02 pos Sequence Context AA Info Type
rs1048716 -- 32,305,905(+) TAGGT(A/C/G/T)AATAT intron-variant, utr-variant-3-prime
rs1137922 -- 32,307,740(+) tggcc(A/G)acatg downstream-variant-500B
rs1137923 -- 32,307,741(+) ggcca(A/G)catgg downstream-variant-500B
rs1137924 -- 32,307,765(+) ctact(A/G)aaaat downstream-variant-500B
rs1137925 -- 32,307,776(+) acaaa(A/G)attag downstream-variant-500B

Structural Variations from Database of Genomic Variants (DGV) for YIPF4 Gene

Variant ID Type Subtype PubMed ID
dgv3748n100 CNV gain 25217958
esv2422335 CNV duplication 17116639
esv3590245 CNV gain 21293372
nsv819851 CNV loss 19587683

Variation tolerance for YIPF4 Gene

Residual Variation Intolerance Score: 34.2% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.25; 24.96% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for YIPF4 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for YIPF4 Gene

Disorders for YIPF4 Gene

Relevant External Links for YIPF4

Atlas of Genetics and Cytogenetics in Oncology and Haematology:

No disorders were found for YIPF4 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for YIPF4 Gene

Publications for YIPF4 Gene

  1. Characterization of YIPF3 and YIPF4, cis-Golgi localizing Yip domain family proteins. (PMID: 21757827) Tanimoto K. … Nakamura N. (Cell Struct. Funct. 2011) 3 4 65
  2. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4 65
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4 65
  4. Neuroblastoma oligo-capping cDNA project: toward the understanding of the genesis and biology of neuroblastoma. (PMID: 12880961) Ohira M. … Nakagawara A. (Cancer Lett. 2003) 3 4 65
  5. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg R.L. … Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002) 2 3 65

Products for YIPF4 Gene

Sources for YIPF4 Gene