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YIPF4 Gene

protein-coding GIFtS: 46

GC02P032356

Yip1 domain family, member 4
Symbol approved by the HUGO Gene Nomenclature Committee (HGNC) database

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc , and/or ⁷Ensembl, ⁸miRBase)
About This Section

Aliases
FinGER4 ^¹, ²
MGC11061 ^¹, ²
Nbla11189 ^²

Descriptions
YIP1 family member 4 ^³
Yip1 domain family, member 4 ^²
putative protein product of Nbla11189 ^²

External Ids
HGNC: 28145¹
Entrez Gene: 84272²
UniProtKB: Q9BSR8³
Ensembl: ENSG00000119820⁷

Search outside databases for aliases for YIPF4 gene

Previous GC identifer: GC02P032416

(According to Entrez Gene, Wikipedia's Gene Wiki,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Gene Wiki entry for YIPF4

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 36),
and/or miRBase,
Genomic Views according to UCSC and Ensembl, Transcription factor binding sites according to SABiosciences)
About This Section

Genomic View:

UCSC Golden Path with GeneCards custom track

Transcription factor binding sites upstream to the YIPF4 gene

Entrez Gene cytogenetic band: 2p22.3 Ensembl cytogenetic band: 2p22.3 HGNC cytogenetic band: 2p22.3

YIPF4 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)

GeneLoc gene densities for chromosome 2 GeneLoc Exon Structure

GeneLoc location for GC02P032356: (about GC identifiers)

Start:	32,356,483 bp from pter
End:	32,385,158 bp from pter
Size:	28,676 bases
Orientation:	plus strand

RefSeq DNA sequence:

NC_000002.10 NT_022184.14

(According to ¹UniProtKB, and/or Ensembl, Phosphorylation sites according to ²Phosphosite, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Enzo Life Sciences, Abnova, OriGene and/or, Abcam,
Biochemical Assays by Invitrogen, Millipore, R&D Systems, Cell Signaling Technology, and/or Enzo Life Sciences, Ontologies according to Gene Ontology Consortium 01 Apr 2009 and Entrez Gene, Antibodies by Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Cell Signaling Technology, Abcam, Abnova, and/or Novus Biologicals)
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UniProtKB/Swiss-Prot: YIPF4_HUMAN, Q9BSR8 (See protein sequence)

Recommended Name: Protein YIPF4

Size: 244 amino acids; 27083 Da

Subcellular location: Membrane; Multi-pass membrane protein (Potential)

Post-translational modifications:

View phosphorylation sites using PhosphoSite²

REFSEQ proteins: NP_115688.1

ENSEMBL proteins:

ENSP00000238831

Human Recombinant Proteins

	Browse Drug Discovery Central at Invitrogen for human recombinant proteins
	Browse Purified and Recombinant Proteins at Millipore
	Browse Human Recombinant Proteins at Sigma-Aldrich
	Browse R&D Systems for human recombinant proteins
	Browse recombinant and purified proteins available from Enzo Life Sciences
	Browse Abcam for Recombinant Proteins
	Browse Abnova for Human Recombinant Proteins

Browse Origene for full length recombinant human proteins expressed in human HEK293 cells

3 Gene Ontology (GO) cellular component terms (links to tree view):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005783	endoplasmic reticulum	IDA	11256614
GO:0016020	membrane	IEA	--
GO:0016021	integral to membrane	IEA	--

About this table

Antibodies for YIPF4:

	Browse Antibodies Central at Invitrogen
	Browse Millipore's Extensive Line of Mono- and Polyclonal Antibodies
	Sigma-Aldrich Antibodies for YIPF4
	Browse R&D Systems for Antibodies
	Search for antibodies at Abcam and the World's Antibody Gateway (free search engine of over 150 antibody companies)
	Browse Abnova for Monoclonal and Polyclonal Antibodies
	Search Novus for antibodies for YIPF4

Assays for YIPF4:

	Browse Invitrogen for biochemical assays
	Browse Kits and Assays available from Millipore
	Browse R&D Systems for biochemical assays
	Browse biochemical assays available from Enzo Life Sciences

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

Graphical View of Domain Structure for InterPro Entry Q9BSR8

ProtoNet protein and cluster: Q9BSR8

UniProtKB/Swiss-Prot: YIPF4_HUMAN, Q9BSR8

Similarity: Belongs to the YIP1 family

(According to MGI Jun 06 2009, UniProtKB, IUBMB,and/or Genatlas,
shRNA from OriGene, Sigma-Aldrich, RNAi from Sigma-Aldrich,
RNAi Products, Clones, and Q-PCR Products from Invitrogen, Millipore, OriGene, and/or Abnova, siRNAs from Applied Biosystems, SYBR primers from OriGene, Cell-based Assays from Millipore, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
About This Section

Inhib. RNA:		Invitrogen RNAi Products for gene knock-down (YIPF4)
		Browse for Gene Knock-down Tools from Millipore
		Browse Abnova for Chimera RNAi Products

OriGene 29mer shRNA kit in GFP-retroviral vector: NM_032312

Applied Biosystems Silencer® siRNAs for YIPF4

Sigma-Aldrich siRNA for YIPF4

Sigma-Aldrich shRNA for YIPF4

Explore Sigma-Aldrich super-pooled esiRNAs

Clones:		Invitrogen Clones for YIPF4
		Browse Clones for the Expression of Recombinant Proteins Available from Millipore

OriGene GFP tagged cDNA clone in CMV expression vector: NM_032312
Myc/DDK tagged cDNA clone in CMV expression vector: NM_032312
untagged cDNA clone in CMV expression vector: NM_032312

Primers:

Browse Quantitative PCR Central at Invitrogen for Q-PCR LUX™ Primers

OriGene genome-wide validated SYBR primer pairs: NM_032312

(Pathways according to Invitrogen (maps by GeneGo), Millipore, Cell Signaling Technology, Sigma-Aldrich, KEGG and/or UniProtKB,
Sets of similar genes according to GeneDecks, Proteins Network according to SABiosciences, Interactions according to ¹UniProtKB, ²MINT, and/or ³STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
About This Section

1 Interacting protein for YIPF4 (Q9BSR8²) via UniProtKB, MINT, and/or STRING
Interactant Interaction Details
GeneCard External ID(s)
-- Q9NWE3² MINT-68058
About this table

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, Sigma-Aldrich, Tocris Bioscience, and/or Novoseek and Drugs according to Enzo Life Sciences and/or PharmGKB)
About This Section

Browse drugs & compounds from Enzo Life Sciences

Browse Small Molecules at Sigma-Aldrich

Browse Tocris compounds for YIPF4

(GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 219 Homo sapiens; Jun 2 2009) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView,
non coding RNAs according to RNAdb,
ESTs according to GeneTide,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from Invitrogen, Millipore, and/or Abnova,
siRNAs from Applied Biosystems, Sigma-Aldrich,
shRNA from Sigma-Aldrich, OriGene,
Tagged/untagged cDNA clones from OriGene,
Expression Assays from Applied Biosystems)
About This Section

Inhib. RNA:		Invitrogen RNAi Products for gene knock-down (YIPF4)
		Browse for Gene Knock-down Tools from Millipore
		Browse Abnova for Chimera RNAi Products

OriGene 29mer shRNA kit in GFP-retroviral vector: NM_032312

Sigma-Aldrich siRNA for YIPF4

Sigma-Aldrich shRNA for YIPF4

Explore Sigma-Aldrich super-pooled esiRNAs

Applied Biosystems Silencer® siRNAs:

NM_032312

REFSEQ mRNAs for YIPF4 gene:

NM_032312.3

Applied Biosystems TaqMan ® Gene Expression Assays:

NM_032312

              OriGene GFP tagged cDNA clone in CMV expression vector: NM_032312
                                 Myc/DDK tagged cDNA clone in CMV expression vector: NM_032312
                                 untagged cDNA clone in CMV expression vector: NM_032312

Additional cDNA sequence:

AB072898.1 AK098486.1 BC004875.2

10 DOTS entries:

DT.445375 DT.100786410 DT.95278781 DT.121019647 DT.86853571 DT.100786408 DT.121019649 DT.95278782

DT.86995158 DT.95278780

24/144 AceView cDNA sequences (see all 144 ):

CA942153 BP338222 CK823050 AI554076 BF594359 NM_032312 BM712551 BG036183

AA223546 BM764320 AK098486 BQ101107 BC004875 AL709356 BM760364 BU607528

CK823051 AW572456 BP341511 BE139521 AU279440 CB123136 BQ100815 BG682213

highest scoring ESTs for YIPF4:

AA126686 AA136748 AA136779 AA223546 AA283121 AA284221 AA286996 AA287059 AA715376 AI079991

Unigene Cluster for YIPF4:

Yip1 domain family, member 4

Hs.468099 [show with all ESTs]

Unigene Representative Sequence: NM_032312

GeneLoc Exon Structure

5 Alternative Splicing Database (ASD) splice patterns (SP) for YIPF4

ExUns:	1a	·	1b	·	1c	^	2	^	3a	·	3b	^	4	^	5a	·	5b	^	6a	·	6b	·	6c
SP1:
SP2:													-
SP3:							-		-		-
SP4:													-
SP5:									-		-

About this scheme

ECgene alternative splicing isoforms for YIPF4

1 Ensembl transcript including schematic representation:

ENST00000238831

(Experimental results according to ¹GeneNote and GNF BioGPS,
probe sets-to-genes annotations according to ²GeneAnnot , ³GeneTide , Sets of similar genes according to GeneDecks, Electronic Northern calculations according to data from UniGene (Build 219 Homo sapiens), SAGE tags according to CGAP, plus additional links to SOURCE, and/or GNF BioGPS, and/or EXPOLDB, and/or UniProtKB,
Expression Assays from Applied Biosystems )
About This Section

YIPF4 expression in normal and diseased human tissues

Applied Biosystems TaqMan ® Gene Expression Assays for YIPF4

¹ / ² / ³

3 probe-sets matching YIPF4 gene

Affymetrix probe-set	Array	# genes	Sensitivity	Specificity	Correlation	Length	Gb_Accession	Consensus	Uniqueness	Score	Rank
Affymetrix probe-set	Array	GeneAnnot data			GeneNote data		GeneTide data
41843_r_at²^{, 3}	U95-A	1	1.00	1.00	1.00	1.00	W28275	0.80	1.00	0.91	1
209551_at²^{, 3}	U133-A	1	1.00	1.00	--	--	BC004875	0.80	1.00	0.91	1
209551_at²	U133Plus2	1	1.00	1.00	--	--	--	--	--	--	--

About this table

Data from

(Publications) and GNF BioGPS
About these images
About these images

CGAP SAGE TAG: CTTCGATACT

SOURCE GeneReport for Unigene cluster: Hs.468099

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD and/or ⁵MGI Jun 06 2009, with possible further links to Flybase and/or WormBase, Gene Trees according to Ensembl)
About This Section

Orthologs for YIPF4 gene from 5/12 species (see all 12 )

Organism	Gene	Locus	Description	Human Similarity	NCBI accessions
dog (Canis familiaris)	YIPF4¹	--	Yip1 domain family, member 4	95.36(n) 98.77(a)	475717 XM_532925.2 XP_532925.1
chimpanzee (Pan troglodytes)	YIPF4¹	--	Yip1 domain family, member 4	99.73(n) 100(a)	743691 XM_001164632.1 XP_001164632.1
cow (Bos taurus)	YIPF4¹	--	Yip1 domain family, member 4	96.01(n) 98.35(a)	615287 XM_867053.2 XP_872146.2
rat (Rattus norvegicus)	Yipf4¹	--	Yip1 domain family, member 4	93.17(n) 97.95(a)	362699 NM_001009712.1 NP_001009712.1
mouse (Mus musculus)	Yipf4^{1, 5}	17⁵	Yip1 domain family, member 4^{1, 5}	93.31(n)¹ 97.95(a)¹	67864¹ NM_026417.3¹ NP_080693.2¹ AI839116⁵ AK009618⁵ (see all 13)

About this table Species with no ortholog for YIPF4

ENSEMBL Gene Tree for YIPF4

(Paralogs according to ¹HomoloGene
and ²Ensembl, Pseudogenes according to ³Pseudogene.org)
About This Section

Paralogs for YIPF4 gene

YIPF6²

(According to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, and UniProtKB, Linkage Disequilibrium by HapMap, Genotyping Reagents from Applied Biosystems)
About This Section

10/117 NCBI SNPs in YIPF4 are shown (see all 117 )
(Click for Applied Biosystems TaqMan ® Genotyping Assay) (see all 26)

AB	SNP ID	Valid	Chr 2 pos	Sequence	Recs	AA Chg	Type	More	Recs	Pop	Total sample	More
AB	Genomic Data				Transcription Data				Allele Frequencies
				--	--	--		--	--			--
	rs396146^1,2	C,F,H,O	32356070(+)	`TTTATT/CTTCAT`	1	--	ng5¹ tfbs³		9	MN EU EA WA	1022
	rs387780^1,2	A,C,F,H	32355999(+)	`AGTTTC/TCTCCC`	1	--	ng5¹ trp³		4	EU EA WA	416
	rs1048716^1,2	C,F,H	32384478(-)	`TAGGTG/TAATAT`	1	--	ut3¹ ese³		5	MN EU EA WA	602
--	rs805830^1,2	C,F	32354979(+)	`gagagC/Ttcggg`	1	--	ng5¹		1	MN	184
	rs6741519^1,2	F,H	32385185(+)	`TGATAT/CTTTAA`	1	--	ng3¹		4	EU EA WA	416
	rs455737^1,2	A,C,F,H	32381738(+)	`tttgaG/Aatcaa`	1	--	int¹		1	EU	120
	rs1153121^1,2	A,C,F,H	32378416(+)	`agctgG/Agtgtg`	1	--	int¹		4	EU EA WA	418
	rs458628^1,2	A,C,F,H	32368902(+)	`TAGATA/GTCTGT`	1	--	int¹		9	NS EU EA WA	510
	rs390480^1,2	A,C,F,H	32363576(-)	`tacccA/Cggaga`	1	--	int¹		5	MN EU EA WA	602
	rs4952258^1,2	A,C,F,H	32362834(+)	`ATATCG/ATGAAG`	1	--	int¹		8	EU EA WA	832

About this table

HapMap Linkage Disequilibrium images for YIPF4 (up to first 250kb)

(in which this Gene is Involved, According to OMIM, UniProtKB, PharmGKB, Genatlas, GeneTests, Blood group antigen gene mutations by BGMUT, HGMD, GAD, HuGE Navigator, BCGD, and/or TGDB.)
About This Section

(Possibly Related Articles in Doctor's Guide)
About This Section

(in PubMed. Associations of this gene to articles via ¹Novoseek, ²HGNC, ³Entrez Gene, ⁴UniProtKB/Swiss-Prot, ⁵UniProtKB/TrEMBL, ⁶GAD, and/or ⁷PharmGKB)
About This Section

10/11 PubMed articles for YIPF4 gene (see all 11 ):

The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)^{3, 4} Gerhard D.S....Malek J. (2004)
Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)^{3, 4} Ota T....Sugano S. (2004)
Neuroblastoma oligo-capping cDNA project: toward the understanding of the genesis and biology of neuroblastoma. (PubMed id 12880961)^{3, 4} Ohira M.... Nakagawara A. (2003)
Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)^{2, 3} Strausberg R.L....Marra M.A. (2002)
The LIFEdb database in 2006. (PubMed id 16381901)³ Mehrle A....Wiemann S. (2006)
Towards a proteome-scale map of the human protein-protein interaction network. (PubMed id 16189514)³ Rual J.F....Vidal M. (2005)
Sequence comparison of human and mouse genes reveals a homologous block structure in the promoter regions. (PubMed id 15342556)³ Suzuki Y.... Sugano S. (2004)
From ORFeome to biology: a functional genomics pipeline. (PubMed id 15489336)³ Wiemann S....Poustka A. (2004)
Systematic subcellular localization of novel proteins identified by large-scale cDNA sequencing. (PubMed id 11256614)³ Simpson J.C.... Wiemann S. (2000)
DNA cloning using in vitro site-specific recombination. (PubMed id 11076863)³ Hartley J.L....Brasch M.A. (2000)

(in PubMed, OMIM, and NCBI Bookshelf)
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		AND	OR
Aliases
Free Text

Query String		PubMed OMIM NCBI Bookshelf
	(Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, and/or H-InvDB)
About This Section

Entrez Gene: 84272	HGNC: 28145	AceView: MGC11061	Ensembl:ENSG00000119820	euGenes: HUgn84272
ECgene: YIPF4	H-InvDB: YIPF4

(According to HUGE)
About This Section

(According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section

Licensable Technologies for YIPF4
(Available from WIS Yeda, Salk, Tufts)

About This Section

(Reagents available from Applied Biosystems, Antibodies and assays by Cell Signaling Technology, Abcam, Novus Biologicals,
Sigma-Aldrich, R&D Systems, Millipore, Abnova, and/or Invitrogen, Clones available from OriGene,and/or Invitrogen, Drugs and/or compounds by Sigma-Aldrich,
Enzo Life Sciences, and/or Tocris Bioscience)
About This Section

Products for YIPF4:

TaqMan ® Gene Expression Assays

TaqMan ® Genotyping Assays

Free SNP selection tool

Invitrogen iPath Pathways	Invitrogen BLOCK-iT™ RNAi
Invitrogen Antibodies	Invitrogen Assays
Invitrogen Clones	Invitrogen Q-PCR Products
Invitrogen Human Recombinant Kinases	Invitrogen Custom Antibody and Peptide Service
Invitrogen Proteins / Assays / Screening Services	Search Invitrogen catalog for YIPF4-related products

	Millipore Custom Antibody & Bulk Services
	Millipore Preclinical / Clinical Development Services
	Millipore Immunoassay Services
	Millipore Target Screening & Profiling Services

	Predesigned and custom siRNAs for YIPF4		Antibodies for YIPF4
	Explore super-pooled esiRNAs		Browse proteins at Sigma-Aldrich
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	Multiplex/Array Assay Kits & Reagents		ELISpot Kits & Development Modules
	Recombinant & Natural Proteins

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YIPF4 Gene

protein-coding GIFtS: 46

Aliases &
Descriptions
for YIPF4

Summaries
for YIPF4

Genomic Location
for YIPF4

Proteins
for YIPF4

Protein Domains/
Families
for YIPF4

Gene Function
for YIPF4

Pathways & Interactions
for YIPF4

Drugs & Compounds
for YIPF4

Transcripts
for YIPF4

Expression
for YIPF4

Orthologs
for YIPF4

Paralogs
for YIPF4

SNPs/Variants
for YIPF4

Disorders & Mutations
for YIPF4

Medical News
for YIPF4

Publications
for YIPF4

Search for YIPF4

Genome Databases showing YIPF4

Other Databases showing YIPF4

Specialized Databases showing YIPF4

Licensable Technologies
for YIPF4

Services
for YIPF4

Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

YIPF4 Gene

protein-coding GIFtS: 46

Aliases & Descriptionsfor YIPF4

Summariesfor YIPF4

Genomic Locationfor YIPF4

Proteinsfor YIPF4

Protein Domains/Familiesfor YIPF4

Gene Functionfor YIPF4

Pathways & Interactionsfor YIPF4

Drugs & Compoundsfor YIPF4

Transcriptsfor YIPF4

Expression for YIPF4

Orthologsfor YIPF4

Paralogsfor YIPF4

SNPs/Variantsfor YIPF4

Disorders & Mutationsfor YIPF4

Medical Newsfor YIPF4

Publicationsfor YIPF4

Search for YIPF4

Genome Databases showing YIPF4

Other Databases showing YIPF4

Specialized Databases showing YIPF4

Licensable Technologiesfor YIPF4

Servicesfor YIPF4

Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

Aliases &
Descriptions
for YIPF4

Summaries
for YIPF4

Genomic Location
for YIPF4

Proteins
for YIPF4

Protein Domains/
Families
for YIPF4

Gene Function
for YIPF4

Pathways & Interactions
for YIPF4

Drugs & Compounds
for YIPF4

Transcripts
for YIPF4

Expression
for YIPF4

Orthologs
for YIPF4

Paralogs
for YIPF4

SNPs/Variants
for YIPF4

Disorders & Mutations
for YIPF4

Medical News
for YIPF4

Publications
for YIPF4

Licensable Technologies
for YIPF4

Services
for YIPF4