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YIPF2 Gene

protein-coding GIFtS: 41

GC19M010895

Yip1 domain family, member 2
Symbol approved by the HUGO Gene Nomenclature Committee (HGNC) database

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc , and/or ⁷Ensembl, ⁸miRBase)
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Aliases
FinGER2 ^¹, ²
MGC3262 ^¹, ²

Descriptions
YIP1 family member 2 ^³
Yip1 domain family, member 2 ^²

External Ids
HGNC: 28476¹
Entrez Gene: 78992²
UniProtKB: Q9BWQ6³
Ensembl: ENSG00000130733⁷

Search outside databases for aliases for YIPF2 gene

(According to Entrez Gene, Wikipedia's Gene Wiki,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 36),
and/or miRBase,
Genomic Views according to UCSC and Ensembl, Transcription factor binding sites according to SABiosciences)
About This Section

Genomic View:

UCSC Golden Path with GeneCards custom track

Transcription factor binding sites upstream to the YIPF2 gene

Entrez Gene cytogenetic band: 19p13.2 Ensembl cytogenetic band: 19p13.2 HGNC cytogenetic band: 19p13.2

YIPF2 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)

GeneLoc gene densities for chromosome 19 GeneLoc Exon Structure

GeneLoc location for GC19M010895: (about GC identifiers)

Start:	10,894,444 bp from pter
End:	10,900,357 bp from pter
Size:	5,914 bases
Orientation:	minus strand

RefSeq DNA sequence:

NC_000019.8 NT_011295.10

(According to ¹UniProtKB, and/or Ensembl, Phosphorylation sites according to ²Phosphosite, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Enzo Life Sciences, Abnova, OriGene and/or, Abcam,
Biochemical Assays by Invitrogen, Millipore, R&D Systems, Cell Signaling Technology, and/or Enzo Life Sciences, Ontologies according to Gene Ontology Consortium 01 Apr 2009 and Entrez Gene, Antibodies by Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Cell Signaling Technology, Abcam, Abnova, and/or Novus Biologicals)
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UniProtKB/Swiss-Prot: YIPF2_HUMAN, Q9BWQ6 (See protein sequence)

Recommended Name: Protein YIPF2

Size: 316 amino acids; 35151 Da

Subcellular location: Membrane; Multi-pass membrane protein (Potential)

REFSEQ proteins: NP_076934.1

ENSEMBL proteins:

ENSP00000377144 ENSP00000253031

Human Recombinant Proteins

	Browse Drug Discovery Central at Invitrogen for human recombinant proteins
	Browse Purified and Recombinant Proteins at Millipore
	Browse Human Recombinant Proteins at Sigma-Aldrich
	Browse R&D Systems for human recombinant proteins
	Browse recombinant and purified proteins available from Enzo Life Sciences
	Browse Abcam for Recombinant Proteins
	Browse Abnova for Human Recombinant Proteins

Browse Origene for full length recombinant human proteins expressed in human HEK293 cells

3 Gene Ontology (GO) cellular component terms (links to tree view):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0016020	membrane	IEA	--
GO:0016021	integral to membrane	IEA	--
GO:0030133	transport vesicle	IDA	11256614

About this table

Antibodies for YIPF2:

	Browse Antibodies Central at Invitrogen
	Browse Millipore's Extensive Line of Mono- and Polyclonal Antibodies
	Sigma-Aldrich Antibodies for YIPF2
	Browse R&D Systems for Antibodies
	Search for antibodies at Abcam and the World's Antibody Gateway (free search engine of over 150 antibody companies)
	Browse Abnova for Monoclonal and Polyclonal Antibodies
	Search Novus for antibodies for YIPF2

Assays for YIPF2:

	Browse Invitrogen for biochemical assays
	Browse Kits and Assays available from Millipore
	Browse R&D Systems for biochemical assays
	Browse biochemical assays available from Enzo Life Sciences

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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Graphical View of Domain Structure for InterPro Entry Q9BWQ6

ProtoNet protein and cluster: Q9BWQ6

UniProtKB/Swiss-Prot: YIPF2_HUMAN, Q9BWQ6

Similarity: Belongs to the YIP1 family

(According to MGI Jun 06 2009, UniProtKB, IUBMB,and/or Genatlas,
shRNA from OriGene, Sigma-Aldrich, RNAi from Sigma-Aldrich,
RNAi Products, Clones, and Q-PCR Products from Invitrogen, Millipore, OriGene, and/or Abnova, siRNAs from Applied Biosystems, SYBR primers from OriGene, Cell-based Assays from Millipore, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
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Inhib. RNA:		Invitrogen RNAi Products for gene knock-down (YIPF2)
		Browse for Gene Knock-down Tools from Millipore
		Browse Abnova for Chimera RNAi Products

OriGene 29mer shRNA kit in GFP-retroviral vector: NM_024029

Applied Biosystems Silencer® siRNAs for YIPF2

Sigma-Aldrich siRNA for YIPF2

Sigma-Aldrich shRNA for YIPF2

Explore Sigma-Aldrich super-pooled esiRNAs

Clones:		Browse Clone Ranger at Invitrogen for clones
		Browse Clones for the Expression of Recombinant Proteins Available from Millipore

OriGene GFP tagged cDNA clone in CMV expression vector: NM_024029
Myc/DDK tagged cDNA clone in CMV expression vector: NM_024029
untagged cDNA clones in CMV expression vector (see all 2): NM_024029

Primers:

Browse Quantitative PCR Central at Invitrogen for Q-PCR LUX™ Primers

OriGene genome-wide validated SYBR primer pairs: NM_024029

(Pathways according to Invitrogen (maps by GeneGo), Millipore, Cell Signaling Technology, Sigma-Aldrich, KEGG and/or UniProtKB,
Sets of similar genes according to GeneDecks, Proteins Network according to SABiosciences, Interactions according to ¹UniProtKB, ²MINT, and/or ³STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
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(Chemical Compounds according to UniProtKB, Enzo Life Sciences, Sigma-Aldrich, Tocris Bioscience, and/or Novoseek and Drugs according to Enzo Life Sciences and/or PharmGKB)
About This Section

Browse drugs & compounds from Enzo Life Sciences

Browse Small Molecules at Sigma-Aldrich

Browse Tocris compounds for YIPF2

(GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 219 Homo sapiens; Jun 2 2009) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView,
non coding RNAs according to RNAdb,
ESTs according to GeneTide,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from Invitrogen, Millipore, and/or Abnova,
siRNAs from Applied Biosystems, Sigma-Aldrich,
shRNA from Sigma-Aldrich, OriGene,
Tagged/untagged cDNA clones from OriGene,
Expression Assays from Applied Biosystems)
About This Section

Inhib. RNA:		Invitrogen RNAi Products for gene knock-down (YIPF2)
		Browse for Gene Knock-down Tools from Millipore
		Browse Abnova for Chimera RNAi Products

OriGene 29mer shRNA kit in GFP-retroviral vector: NM_024029

Sigma-Aldrich siRNA for YIPF2

Sigma-Aldrich shRNA for YIPF2

Explore Sigma-Aldrich super-pooled esiRNAs

Applied Biosystems Silencer® siRNAs:

NM_024029

REFSEQ mRNAs for YIPF2 gene:

NM_024029.3

Applied Biosystems TaqMan ® Gene Expression Assays:

NM_024029

              OriGene GFP tagged cDNA clone in CMV expression vector: NM_024029
                                 Myc/DDK tagged cDNA clone in CMV expression vector: NM_024029
                                 untagged cDNA clones in CMV expression vector (see all 2): NM_024029

Additional cDNA sequence:

BC000056.2 BC013014.2 CR591972.1 CR601786.1

16 DOTS entries:

DT.100883374 DT.97775761 DT.100883380 DT.100883383 DT.85104699 DT.220742 DT.100661719 DT.100883379

DT.100883375 DT.100709504 DT.100681577 DT.100883361 DT.91765876 DT.91765885 DT.97855193 DT.100686557

24/245 AceView cDNA sequences (see all 245 ):

BU149676 BU857035 BU625482 CR601786 BM554546 BF530383 NM_024029 BX332273

BU626264 BU944073 BX641860 BI713049 AI380798 BQ676152 BQ960215 CK904640

BM975967 BM682976 BQ678064 CN483950 BX387531 BG762911 AI420432 AW473895

highest scoring ESTs for YIPF2:

AL527265 AL529424 BC000056 BC013014 BE300008 BF569803 BG769627 BI755401 BI829175 BM544083

Unigene Cluster for YIPF2:

Yip1 domain family, member 2

Hs.323213 [show with all ESTs]

Unigene Representative Sequence: NM_024029

GeneLoc Exon Structure

5 Alternative Splicing Database (ASD) splice patterns (SP) for YIPF2

ExUns:	1	^	2	^	3	^	4	^	5a	·	5b	·	5c	^	6a	·	6b	^	7a	·	7b	^	8	^	9a	·	9b	·	9c
SP1:
SP2:															-
SP3:
SP4:
SP5:

About this scheme

ECgene alternative splicing isoforms for YIPF2

2 Ensembl transcripts including schematic representations:

ENST00000393508 ENST00000253031

(Experimental results according to ¹GeneNote and GNF BioGPS,
probe sets-to-genes annotations according to ²GeneAnnot , ³GeneTide , Sets of similar genes according to GeneDecks, Electronic Northern calculations according to data from UniGene (Build 219 Homo sapiens), SAGE tags according to CGAP, plus additional links to SOURCE, and/or GNF BioGPS, and/or EXPOLDB, and/or UniProtKB,
Expression Assays from Applied Biosystems )
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YIPF2 expression in normal and diseased human tissues

Applied Biosystems TaqMan ® Gene Expression Assays for YIPF2

¹ / ² / ³

5 probe-sets matching YIPF2 gene

Affymetrix probe-set	Array	# genes	Sensitivity	Specificity	Correlation	Length	Gb_Accession	Consensus	Uniqueness	Score	Rank
Affymetrix probe-set	Array	GeneAnnot data			GeneNote data		GeneTide data
65086_at²^{, 3}	U133-C	1	1.00	1.00	1.00	1.00	Z78349	0.80	1.00	0.91	1
65086_at²^{, 3}	U133-A	1	1.00	1.00	--	--	Z78349	0.80	1.00	0.91	1
219075_at²^{, 3}	U133-A	1	1.00	1.00	--	--	NM_024029	0.60	1.00	0.82	1
65086_at²	U133Plus2	1	1.00	1.00	--	--	--	--	--	--	--
219075_at²	U133Plus2	1	1.00	1.00	--	--	--	--	--	--	--

GeneDecks YIPF2 for binary patterns associated with the probe-sets selected above

About GeneDecksing

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Data from

(Publications) and GNF BioGPS
About these images
About these images

CGAP SAGE TAG: GGCTGTAAGT

SOURCE GeneReport for Unigene cluster: Hs.323213

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD and/or ⁵MGI Jun 06 2009, with possible further links to Flybase and/or WormBase, Gene Trees according to Ensembl)
About This Section

Orthologs for YIPF2 gene from 5/12 species (see all 12 )

Organism	Gene	Locus	Description	Human Similarity	NCBI accessions
dog (Canis familiaris)	YIPF2¹	--	Yip1 domain family, member 2	86.67(n) 85.57(a)	484946 XM_542062.2 XP_542062.2
chimpanzee (Pan troglodytes)	YIPF2¹	--	Yip1 domain family, member 2	99.26(n) 99.05(a)	746146 XM_001166931.1 XP_001166931.1
cow (Bos taurus)	YIPF2¹	--	Yip1 domain family, member 2	86.34(n) 86.45(a)	515893 XM_593996.3 XP_593996.2
rat (Rattus norvegicus)	Yipf2¹	--	Yip1 domain family, member 2	79.59(n) 82.41(a)	363027 NM_001014208.1 NP_001014230.1
mouse (Mus musculus)	Yipf2^{1, 5}	9⁵	Yip1 domain family, member 2^{1, 5}	79.76(n)¹ 82.47(a)¹	74766¹ NM_138303.1¹ NP_612176.1¹ AK004959⁵ AK033705⁵ (see all 8)

About this table Species with no ortholog for YIPF2

ENSEMBL Gene Tree for YIPF2

(Paralogs according to ¹HomoloGene
and ²Ensembl, Pseudogenes according to ³Pseudogene.org)
About This Section

Paralogs for YIPF2 gene

YIPF1²

(According to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, and UniProtKB, Linkage Disequilibrium by HapMap, Genotyping Reagents from Applied Biosystems)
About This Section

10 NCBI SNPs in YIPF2 are shown
(Click for Applied Biosystems TaqMan ® Genotyping Assay) (only AB snps)

AB	SNP ID	Valid	Chr 19 pos	Sequence	Recs	AA Chg	Type	More	Recs	Allele freq	Pop	Total sample	More
AB	Genomic Data				Transcription Data				Allele Frequencies
				--	--	--		--	--				--
	rs2304086^1,2	C,F,H	10895846(-)	`GCCACG/ATTGGC`	1	T/T	syn¹ ese³		9		EA EU WA	2302
	rs12985197^1,2	A,C,F,H	10896604(+)	`CCCGAA/GAACAC`	1	--	int¹		6		EU EA WA NA	594
	rs2304085^1,2	F,H	10896069(-)	`AGGGTG/TTGCAG`	1	--	int¹		5		EA EU WA	1898
	rs35026133^1,2	--	10897419(+)	`CCGGGG/ACAGCA`	1	S/P	mis¹		1		NA	76
	rs61747440^1,2	--	10895837(+)	`AGGACC/TAAGGC`	2	F/L	mis¹		0	--	--	--	--
--	rs11544678^1,2	--	10895299(-)	`TGGCCC/GTGGGC`	1	L/V	mis¹ ese³		0	--	--	--	--
--	rs17850995^1,2	--	10895039(+)	`TGGGGA/TGGAGG`	1	P/P	syn¹ ese³		0	--	--	--	--
--	rs10411918^1,2	--	10896441(+)	`TCCCCC/GCACCC`	1	--	int¹		0	--	--	--	--
--	rs45566436^1,2	--	10895977(+)	`ACCTTC/GCCTGA`	1	--	int¹		0	--	--	--	--
--	rs34647007^1,2	--	10898035(+)	`GAGCA-/GGGGAC`	1	--	int¹		0	--	--	--	--

About this table
The following additional 11 SNP(s) have been found in Applied Biosystems data source:

(Click for Applied Biosystems TaqMan ® Genotyping Assay)

rs2304088	rs892010	rs34083039	rs35087899	rs2288842	rs2053065	rs2288843
rs8106381	rs2288841	rs2304089	rs45597736

HapMap Linkage Disequilibrium images for YIPF2 (up to first 250kb)

(in which this Gene is Involved, According to OMIM, UniProtKB, PharmGKB, Genatlas, GeneTests, Blood group antigen gene mutations by BGMUT, HGMD, GAD, HuGE Navigator, BCGD, and/or TGDB.)
About This Section

(Possibly Related Articles in Doctor's Guide)
About This Section

(in PubMed. Associations of this gene to articles via ¹Novoseek, ²HGNC, ³Entrez Gene, ⁴UniProtKB/Swiss-Prot, ⁵UniProtKB/TrEMBL, ⁶GAD, and/or ⁷PharmGKB)
About This Section

7 PubMed articles for YIPF2 gene:

The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)^{3, 4} Gerhard D.S....Malek J. (2004)
Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)^{2, 3} Strausberg R.L....Marra M.A. (2002)
The LIFEdb database in 2006. (PubMed id 16381901)³ Mehrle A....Wiemann S. (2006)
Towards a proteome-scale map of the human protein-protein interaction network. (PubMed id 16189514)³ Rual J.F....Vidal M. (2005)
From ORFeome to biology: a functional genomics pipeline. (PubMed id 15489336)³ Wiemann S....Poustka A. (2004)
Systematic subcellular localization of novel proteins identified by large-scale cDNA sequencing. (PubMed id 11256614)³ Simpson J.C.... Wiemann S. (2000)
DNA cloning using in vitro site-specific recombination. (PubMed id 11076863)³ Hartley J.L....Brasch M.A. (2000)

(in PubMed, OMIM, and NCBI Bookshelf)
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		AND	OR
Aliases
Free Text

Query String		PubMed OMIM NCBI Bookshelf
	(Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, and/or H-InvDB)
About This Section

Entrez Gene: 78992	HGNC: 28476	AceView: MGC3262	Ensembl:ENSG00000130733	euGenes: HUgn78992
ECgene: YIPF2	H-InvDB: YIPF2

(According to HUGE)
About This Section

(According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section

Licensable Technologies for YIPF2
(Available from WIS Yeda, Salk, Tufts)

About This Section

(Reagents available from Applied Biosystems, Antibodies and assays by Cell Signaling Technology, Abcam, Novus Biologicals,
Sigma-Aldrich, R&D Systems, Millipore, Abnova, and/or Invitrogen, Clones available from OriGene,and/or Invitrogen, Drugs and/or compounds by Sigma-Aldrich,
Enzo Life Sciences, and/or Tocris Bioscience)
About This Section

Products for YIPF2:

TaqMan ® Gene Expression Assays

TaqMan ® Genotyping Assays

Free SNP selection tool

Invitrogen iPath Pathways	Invitrogen BLOCK-iT™ RNAi
Invitrogen Antibodies	Invitrogen Assays
Invitrogen Clones	Invitrogen Q-PCR Products
Invitrogen Human Recombinant Kinases	Invitrogen Custom Antibody and Peptide Service
Invitrogen Proteins / Assays / Screening Services	Search Invitrogen catalog for YIPF2-related products

	Millipore Custom Antibody & Bulk Services
	Millipore Preclinical / Clinical Development Services
	Millipore Immunoassay Services
	Millipore Target Screening & Profiling Services

	Predesigned and custom siRNAs for YIPF2		Antibodies for YIPF2
	Explore super-pooled esiRNAs		Browse proteins at Sigma-Aldrich
	Lentivirus-delivered shRNAs for YIPF2		Browse small molecules at Sigma-Aldrich
	"Your Favorite Gene" Pathways		feedback

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	Cell Culture Products		ELISAs
	Flow Cytometry Kits		Protease Activity Assays & Reagents
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	Multiplex/Array Assay Kits & Reagents		ELISpot Kits & Development Modules
	Recombinant & Natural Proteins

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	Custom Service for Rabbit Pab from Full-length Protein

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YIPF2 Gene

protein-coding GIFtS: 41

Aliases &
Descriptions
for YIPF2

Summaries
for YIPF2

Genomic Location
for YIPF2

Proteins
for YIPF2

Protein Domains/
Families
for YIPF2

Gene Function
for YIPF2

Pathways & Interactions
for YIPF2

Drugs & Compounds
for YIPF2

Transcripts
for YIPF2

Expression
for YIPF2

Orthologs
for YIPF2

Paralogs
for YIPF2

SNPs/Variants
for YIPF2

Disorders & Mutations
for YIPF2

Medical News
for YIPF2

Publications
for YIPF2

Search for YIPF2

Genome Databases showing YIPF2

Other Databases showing YIPF2

Specialized Databases showing YIPF2

Licensable Technologies
for YIPF2

Services
for YIPF2

Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

YIPF2 Gene

protein-coding GIFtS: 41

Aliases & Descriptionsfor YIPF2

Summariesfor YIPF2

Genomic Locationfor YIPF2

Proteinsfor YIPF2

Protein Domains/Familiesfor YIPF2

Gene Functionfor YIPF2

Pathways & Interactionsfor YIPF2

Drugs & Compoundsfor YIPF2

Transcriptsfor YIPF2

Expression for YIPF2

Orthologsfor YIPF2

Paralogsfor YIPF2

SNPs/Variantsfor YIPF2

Disorders & Mutationsfor YIPF2

Medical Newsfor YIPF2

Publicationsfor YIPF2

Search for YIPF2

Genome Databases showing YIPF2

Other Databases showing YIPF2

Specialized Databases showing YIPF2

Licensable Technologiesfor YIPF2

Servicesfor YIPF2

Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

Aliases &
Descriptions
for YIPF2

Summaries
for YIPF2

Genomic Location
for YIPF2

Proteins
for YIPF2

Protein Domains/
Families
for YIPF2

Gene Function
for YIPF2

Pathways & Interactions
for YIPF2

Drugs & Compounds
for YIPF2

Transcripts
for YIPF2

Expression
for YIPF2

Orthologs
for YIPF2

Paralogs
for YIPF2

SNPs/Variants
for YIPF2

Disorders & Mutations
for YIPF2

Medical News
for YIPF2

Publications
for YIPF2

Licensable Technologies
for YIPF2

Services
for YIPF2