YIPF2 Gene
protein-coding GIFtS: 45
GCID: GC19M011033
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|
Yip1 domain family, member 2
| |
Aliases
for YIPF2 gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| Yip1 Domain Family, Member 21 2 | | FinGER21 2 | | YIP1 Family Member 22 3 | | MGC32621 | | Protein YIPF22 |
Export aliases for YIPF2 gene to outside databasesPrevious GC identifers: GC19M010895 GC19M010611 |
Summaries
for YIPF2 gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
-- |
Genomic Views
for YIPF2 gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000019.9 NC_018930.1 NT_011295.11
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the YIPF2 gene promoter:
NF-1 Elk-1 Pax-2 XBP-1 Pax-2a c-Ets-1 Egr-4 PPAR-alpha Ik-2 TGIF
Other transcription factors
Search SABiosciences Chromatin IP Primers for YIPF2
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat YIPF2 |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 19p13.2 Ensembl cytogenetic band: 19p13.2 HGNC cytogenetic band: 19p13.2YIPF2 Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 19 GeneLoc Exon Structure GeneLoc location for GC19M011033: view genomic region
(about GC identifiers)
Start:
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11,033,444 bp from pter |
End:
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11,039,357 bp from pter |
Size:
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5,914 bases |
Orientation:
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minus strand |
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Proteins
for YIPF2 gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: YIPF2_HUMAN, Q9BWQ6 (See
protein sequence)Recommended Name: Protein YIPF2 Size: 316 amino acids; 35151 Da
Subcellular location: Membrane; Multi-pass membrane protein (Potential)Explore the universe of human proteins at neXtProt for YIPF2: NX_Q9BWQ6
Post-translational modifications:
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_Q9BWQ6
YIPF2 Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins: NP_076934.1
ENSEMBL proteins: ENSP00000466055 ENSP00000253031 ENSP00000467829 ENSP00000467156 ENSP00000465257 ENSP00000467019 ENSP00000466408 ENSP00000465943 ENSP00000468436 ENSP00000464839
Human Recombinant Protein Products:
Gene Ontology (GO): 2 cellular component terms (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0016021 | integral to membrane |
IEA | -- | | GO:0030133 | transport vesicle |
IDA | -- |
YIPF2 for ontologies About GeneDecksing
YIPF2 Antibody Products:
Assay Products for YIPF2: |
Protein
Domains /
Families
for YIPF2 gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
YIPF2 for domains About GeneDecksing
1 InterPro domain/family:Graphical View of Domain Structure for InterPro Entry Q9BWQ6ProtoNet protein and cluster: Q9BWQ6 UniProtKB/Swiss-Prot: YIPF2_HUMAN, Q9BWQ6Similarity: Belongs to the YIP1 family |
Function
for YIPF2 gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Clone
Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for YIPF2 (see all 3)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for YIPF2 (see all 2)
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
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| |  | GenScript: all cDNA clones in your preferred vector: YIPF2 (NM_024029) | |  | Browse Sino Biological Human cDNA Clones | |  | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for YIPF2 | |  | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat YIPF2 |
In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for YIPF2 |
|
Pathways & Interactions
for YIPF2 gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Interactions:
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for YIPF2
STRING Interaction
Network Preview (showing 2 interactants - click image to see more details)
3 Interacting proteins for YIPF2 (Q9BWQ63 ENSP000002530314) via UniProtKB, MINT, STRING, and/or I2DAbout this table
|
Drugs & Compounds
for YIPF2 gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
 Browse Tocris compounds for YIPF2
Search CenterWatch for drugs/clinical trials and news about YIPF2
|
Transcripts
for YIPF2 gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for YIPF2 gene: NM_024029.3 Unigene Cluster for YIPF2: Yip1 domain family, member 2 Hs.720136 [show with all ESTs]Unigene Representative Sequence: NM_02402912 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000586748 ENST00000253031(uc002mqb.3 uc002mqc.3) ENST00000592646
ENST00000589971 ENST00000591872 ENST00000590329 ENST00000586575 ENST00000587943
ENST00000588347 ENST00000585858 ENST00000588962 ENST00000592505
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for YIPF2 (see all 3)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for YIPF2 (see all 2)
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector: YIPF2 (NM_024029) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for YIPF2 | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat YIPF2 |
Additional cDNA sequence: BC000056.2 BC013014.2 12 DOTS entries: DT.100883374 DT.100883383 DT.97775761 DT.220742 DT.100883375 DT.85104699 DT.100883380 DT.100883361 DT.91765885 DT.97855193 DT.100681577 DT.100709504 24/245 AceView cDNA sequences (see all 245): BC013014 BU753892 BQ928568 AI660225 BE387991 AI420432 AI380798 CK904640 BE391217 NM_024029 AI659144 BC000056 CA413410 BX332273 BQ013072 BQ684682 BI713049 CR601786 BI829175 BM906269 BF530383 BU944073 BU860186 BQ067455
GeneLoc Exon Structure
5 Alternative Splicing Database (ASD) splice patterns (SP) for YIPF2 About this scheme
| ExUns: | 1 | ^ | 2 | ^ | 3 | ^ | 4 | ^ | 5a | · | 5b | · | 5c | ^ | 6a | · | 6b | ^ | 7a | · | 7b | ^ | 8 | ^ | 9a | · | 9b | · | 9c |
|---|
|
| SP1: | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | |
| SP2: | | | | | | | | | | | | | | | - | | | | | | | | | | | | | | | | |
| SP3: | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | |
| SP4: | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | |
| SP5: | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | |
ECgene alternative splicing isoforms for YIPF2
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Expression
for YIPF2 gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| YIPF2 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: GGCTGTAAGT
About this image
See YIPF2 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for YIPF2
SOURCE GeneReport for Unigene cluster: Hs.720136
SABiosciences Custom PCR Arrays for YIPF2
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for YIPF2
Browse OriGene validated miRNA SYBR primer pairs
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse, rat YIPF2 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat YIPF2 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat YIPF2 | In Situ
Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for YIPF2 |
Orthologs
for YIPF2 gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of eukaryotes.
Orthologs for YIPF2 gene from 8/27 species (see all 27) About this table
ENSEMBL Gene Tree for YIPF2 (if available)
TreeFam Gene Tree for YIPF2 (if available) |
Paralogs
for YIPF2 gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| Paralogs for YIPF2 gene
- YIPF12
1 SIMAP similar gene for YIPF2 using alignment to 9 protein entries: YIPF2_HUMAN (see all proteins):YIPF1
YIPF2 for paralogs About GeneDecksing
|
Genomic Variants
for YIPF2 gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 19 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for YIPF2 (11033444 - 11039357 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 1 variation for YIPF2
1 CNV: 5087 | SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing YIPF2 |
|
Disorders
/ Diseases
for YIPF2 gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
YIPF2 for disorders About GeneDecksing
2  diseases for YIPF2: About MalaCardsdenys-drash syndrome nephroblastoma
2 diseases from the University of Copenhagen DISEASES database for YIPF2:Denys-Drash syndrome Nephroblastoma Export disorders for YIPF2 gene to outside databases
|
Publications
for YIPF2 gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for YIPF2 gene integrated from 9 sources:
(articles sorted by number of sources associating them with YIPF2) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
- Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1, 3 Strausberg R.L....Marra M.A. (2002)
- Ubiquitin-mediated proteolysis of HuR by heat shock. (PubMed id 19322201)1 Abdelmohsen K....Gorospe M. (2009)
- The LIFEdb database in 2006. (PubMed id 16381901)1 Mehrle A....Wiemann S. (2006)
- Towards a proteome-scale map of the human protein-protein interaction network. (PubMed id 16189514)1 Rual J.F....Vidal M. (2005)
- From ORFeome to biology: a functional genomics pipeline. (PubMed id 15489336)1 Wiemann S....Poustka A. (2004)
- Systematic subcellular localization of novel proteins identified by large-scale cDNA sequencing. (PubMed id 11256614)1 Simpson J.C.... Wiemann S. (2000)
- DNA cloning using in vitro site-specific recombination. (PubMed id 11076863)1 Hartley J.L....Brasch M.A. (2000)
|
External Searches for YIPF2 gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
|
Genome Databases showing YIPF2 gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing YIPF2 gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing YIPF2 gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
| Name | Description |
| PharmGKB entry for YIPF2 | Pharmacogenomics, SNPs, Pathways |
|
| | |
About This Section
| Patent Information for YIPF2 gene:
Search GeneIP for patents involving YIPF2
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for YIPF2 gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
About This Section
|
 | |
 | |
 |
| | |  | Browse OriGene Antibodies | | OriGene shRNA RFP for YIPF2 | | | OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for YIPF2 | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for YIPF2 | | | OriGene Protein Over-expression Lysate for YIPF2 | | Browse OriGene Fluorogenic Cell Assay Kits | | | OriGene siRNA for YIPF2 | | OriGene 3'-UTR Clone for YIPF2 | | | OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for YIPF2 | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for YIPF2 | | | Browse OriGene GFP tagged cDNA clones in CMV expression vector | | Browse OriGene MicroRNA Expression Plasmids | | | Browse OriGene basic RS shRNAs | | Browse OriGene validated miRNA SYBR primer pairs | | | OriGene Purified Protein for YIPF2 | | OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
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| | | | Search Tocris compounds for YIPF2 |
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 | | | YIPF2 Proteins, Antibodies, CLIAs, and ELISAs |
| | | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for YIPF2 |
|  |  |  | | | | Search ThermoFisher Antibodies for YIPF2 |
| | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat YIPF2 |
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