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Aliases for YIPF2 Gene

Aliases for YIPF2 Gene

  • Yip1 Domain Family Member 2 2 3 5
  • Yip1 Domain Family, Member 2 2 3
  • YIP1 Family Member 2 3 4
  • FinGER2 3

External Ids for YIPF2 Gene

Previous GeneCards Identifiers for YIPF2 Gene

  • GC19M011033
  • GC19M010611

Summaries for YIPF2 Gene

GeneCards Summary for YIPF2 Gene

YIPF2 (Yip1 Domain Family Member 2) is a Protein Coding gene. Diseases associated with YIPF2 include Tarsal-Carpal Coalition Syndrome and Proximal Symphalangism. An important paralog of this gene is YIPF1.

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for YIPF2 Gene

Genomics for YIPF2 Gene

Regulatory Elements for YIPF2 Gene

Enhancers for YIPF2 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around YIPF2 on UCSC Golden Path with GeneCards custom track

Promoters for YIPF2 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around YIPF2 on UCSC Golden Path with GeneCards custom track

Genomic Location for YIPF2 Gene

Chromosome:
19
Start:
10,922,185 bp from pter
End:
10,929,012 bp from pter
Size:
6,828 bases
Orientation:
Minus strand

Genomic View for YIPF2 Gene

Genes around YIPF2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
YIPF2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for YIPF2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for YIPF2 Gene

Proteins for YIPF2 Gene

  • Protein details for YIPF2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9BWQ6-YIPF2_HUMAN
    Recommended name:
    Protein YIPF2
    Protein Accession:
    Q9BWQ6

    Protein attributes for YIPF2 Gene

    Size:
    316 amino acids
    Molecular mass:
    35151 Da
    Quaternary structure:
    No Data Available

neXtProt entry for YIPF2 Gene

Proteomics data for YIPF2 Gene at MOPED

Post-translational modifications for YIPF2 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for YIPF2 Gene

Domains & Families for YIPF2 Gene

Gene Families for YIPF2 Gene

Protein Domains for YIPF2 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for YIPF2 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q9BWQ6

UniProtKB/Swiss-Prot:

YIPF2_HUMAN :
  • Belongs to the YIP1 family.
Family:
  • Belongs to the YIP1 family.
genes like me logo Genes that share domains with YIPF2: view

Function for YIPF2 Gene

Phenotypes for YIPF2 Gene

genes like me logo Genes that share phenotypes with YIPF2: view

Animal Model Products

  • Taconic Biosciences Mouse Models for YIPF2

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for YIPF2 Gene

Localization for YIPF2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for YIPF2 Gene

Membrane; Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for YIPF2 Gene COMPARTMENTS Subcellular localization image for YIPF2 gene
Compartment Confidence
plasma membrane 3
golgi apparatus 2
mitochondrion 2
nucleus 1

Gene Ontology (GO) - Cellular Components for YIPF2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with YIPF2: view

Pathways & Interactions for YIPF2 Gene

SuperPathways for YIPF2 Gene

No Data Available

Gene Ontology (GO) - Biological Process for YIPF2 Gene

None

No data available for Pathways by source and SIGNOR curated interactions for YIPF2 Gene

Drugs & Compounds for YIPF2 Gene

No Compound Related Data Available

Transcripts for YIPF2 Gene

Unigene Clusters for YIPF2 Gene

Yip1 domain family, member 2:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for YIPF2 Gene

ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5a · 5b · 5c ^ 6a · 6b ^ 7a · 7b ^ 8 ^ 9a · 9b · 9c
SP1:
SP2: -
SP3:
SP4:
SP5:

Relevant External Links for YIPF2 Gene

GeneLoc Exon Structure for
YIPF2
ECgene alternative splicing isoforms for
YIPF2

Expression for YIPF2 Gene

mRNA expression in normal human tissues for YIPF2 Gene

Protein differential expression in normal tissues from HIPED for YIPF2 Gene

This gene is overexpressed in Breast (37.9), Oral epithelium (14.3), and Placenta (7.6).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for YIPF2 Gene



SOURCE GeneReport for Unigene cluster for YIPF2 Gene Hs.720136

genes like me logo Genes that share expression patterns with YIPF2: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Protein tissue co-expression partners for YIPF2 Gene

Orthologs for YIPF2 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for YIPF2 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia YIPF2 35
  • 86.34 (n)
  • 86.45 (a)
YIPF2 36
  • 84 (a)
OneToOne
dog
(Canis familiaris)
Mammalia YIPF2 35
  • 86.67 (n)
  • 85.57 (a)
YIPF2 36
  • 84 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Yipf2 35
  • 79.76 (n)
  • 82.47 (a)
Yipf2 16
Yipf2 36
  • 80 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia YIPF2 35
  • 99.26 (n)
  • 99.05 (a)
YIPF2 36
  • 99 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Yipf2 35
  • 79.59 (n)
  • 82.41 (a)
oppossum
(Monodelphis domestica)
Mammalia YIPF2 36
  • 61 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia YIPF2 36
  • 74 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia YIPF2 36
  • 56 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia Str.1767 35
zebrafish
(Danio rerio)
Actinopterygii yipf2 35
  • 55.78 (n)
  • 51.85 (a)
yipf2 36
  • 51 (a)
OneToOne
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.2435 35
fruit fly
(Drosophila melanogaster)
Insecta CG4645 36
  • 26 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea Y25C1A.7 36
  • 23 (a)
OneToMany
soybean
(Glycine max)
eudicotyledons Gma.739 35
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 37 (a)
OneToMany
Species with no ortholog for YIPF2:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for YIPF2 Gene

ENSEMBL:
Gene Tree for YIPF2 (if available)
TreeFam:
Gene Tree for YIPF2 (if available)

Paralogs for YIPF2 Gene

Paralogs for YIPF2 Gene

(1) SIMAP similar genes for YIPF2 Gene using alignment to 9 proteins:

genes like me logo Genes that share paralogs with YIPF2: view

Variants for YIPF2 Gene

Sequence variations from dbSNP and Humsavar for YIPF2 Gene

SNP ID Clin Chr 19 pos Sequence Context AA Info Type
rs12985197 -- 10,924,928(+) CCCGA(A/G)AACAC intron-variant
rs17850995 -- 10,923,363(+) TGGGG(A/T)GGAGG reference, synonymous-codon
rs140126930 -- 10,924,580(+) CCAGG(A/G)CTCTG intron-variant
rs140625609 -- 10,923,965(+) AGCCA(C/T)GCATA reference, synonymous-codon
rs140748561 -- 10,924,758(+) CTCCC(A/C)CTCCC intron-variant

Structural Variations from Database of Genomic Variants (DGV) for YIPF2 Gene

Variant ID Type Subtype PubMed ID
nsv833748 CNV Loss 17160897
nsv911050 CNV Loss 21882294
nsv833749 CNV Loss 17160897
nsv911051 CNV Loss 21882294

Variation tolerance for YIPF2 Gene

Residual Variation Intolerance Score: 97.3% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.96; 36.32% of all genes are more intolerant (likely to be disease-causing)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Relevant External Links for YIPF2 Gene

Disorders for YIPF2 Gene

MalaCards: The human disease database

(3) MalaCards diseases for YIPF2 Gene - From: DISEASES

Disorder Aliases PubMed IDs
tarsal-carpal coalition syndrome
  • tarsal carpal coalition syndrome
proximal symphalangism
  • symphalangism, proximal, 1a
multiple synostoses syndrome
  • multiple synostosis syndrome
- elite association - COSMIC cancer census association via MalaCards
Search YIPF2 in MalaCards View complete list of genes associated with diseases

Relevant External Links for YIPF2

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
YIPF2
genes like me logo Genes that share disorders with YIPF2: view

No data available for UniProtKB/Swiss-Prot and Genatlas for YIPF2 Gene

Publications for YIPF2 Gene

  1. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4 67
  2. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg R.L. … Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002) 2 3
  3. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 3
  4. A proteome-scale map of the human interactome network. (PMID: 25416956) Rolland T. … Vidal M. (Cell 2014) 3
  5. Next-generation sequencing to generate interactome datasets. (PMID: 21516116) Yu H. … Vidal M. (Nat. Methods 2011) 3

Products for YIPF2 Gene

Sources for YIPF2 Gene

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