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Aliases for YIPF2 Gene

Aliases for YIPF2 Gene

  • Yip1 Domain Family Member 2 2 3 5
  • YIP1 Family Member 2 3 4
  • Yip1 Domain Family, Member 2 2
  • Protein YIPF2 3
  • FinGER2 3

External Ids for YIPF2 Gene

Previous GeneCards Identifiers for YIPF2 Gene

  • GC19M011033
  • GC19M010611

Summaries for YIPF2 Gene

GeneCards Summary for YIPF2 Gene

YIPF2 (Yip1 Domain Family Member 2) is a Protein Coding gene. Diseases associated with YIPF2 include Tarsal-Carpal Coalition Syndrome and Symphalangism, Proximal, 1A. An important paralog of this gene is YIPF1.

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for YIPF2 Gene

Genomics for YIPF2 Gene

Regulatory Elements for YIPF2 Gene

Enhancers for YIPF2 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH19F011531 1.5 FANTOM5 Ensembl ENCODE 41.8 -603.4 -603427 1.6 PKNOX1 ATF1 ZFP64 ZNF493 FOS ZNF202 ZNF263 REST ZNF518A ZNF623 ZNF627 ZNF136 ZNF844 ZNF442 ZNF625 ZNF44 ZNF799 ZNF441 ZNF491 ZNF700
GH19F010100 1.5 FANTOM5 ENCODE 40.7 +824.6 824625 8.3 HDGF PKNOX1 CREB3L1 MLX WRNIP1 ZFP64 ARID4B SIN3A YBX1 DMAP1 FBXL12 ZNF699 ZNF561 LOC100419831 ZNF559 TIMM29 YIPF2 ZNF562 EIF3G ZNF121
GH19F011317 1.4 Ensembl ENCODE 41.8 -392.7 -392671 9.0 CREB3L1 ZFP64 DMAP1 YY1 ZNF143 ZNF263 SP3 NFYC TBX21 MEF2D ZNF627 ZNF136 ZNF844 ZNF625 ENSG00000267174 ZNF44 ZNF441 ZNF491 ZNF700 ZNF763
GH19F011420 1.3 Ensembl ENCODE 41.8 -492.8 -492832 3.1 ATF1 PKNOX1 ZNF493 ZFP64 SIN3A DMAP1 ZNF48 ETS1 ZNF121 GLIS2 ZNF627 ZNF136 ZNF442 ZNF844 ZNF625 ZNF44 ZNF799 ZNF763 ZNF441 ZNF491
GH19F010379 1.1 ENCODE 30.5 +548.5 548486 1.9 HDGF PKNOX1 CREB3L1 WRNIP1 ZFP64 ARID4B SIN3A DMAP1 ZNF2 YY1 FBXL12 ZNF561 LOC100419831 RAVER1 TIMM29 ZNF426 YIPF2 ZNF121 ZNF562 EIF3G
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around YIPF2 on UCSC Golden Path with GeneCards custom track

Promoters for YIPF2 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000042990 212 2001 PKNOX1 CREB3L1 WRNIP1 SIN3A DMAP1 ZNF2 YY1 ZNF143 ZNF207 KLF13

Genomic Location for YIPF2 Gene

10,922,185 bp from pter
10,929,012 bp from pter
6,828 bases
Minus strand

Genomic View for YIPF2 Gene

Genes around YIPF2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
YIPF2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for YIPF2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for YIPF2 Gene

Proteins for YIPF2 Gene

  • Protein details for YIPF2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Protein YIPF2
    Protein Accession:

    Protein attributes for YIPF2 Gene

    316 amino acids
    Molecular mass:
    35151 Da
    Quaternary structure:
    No Data Available

neXtProt entry for YIPF2 Gene

Post-translational modifications for YIPF2 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for YIPF2 Gene

Domains & Families for YIPF2 Gene

Gene Families for YIPF2 Gene

Protein Domains for YIPF2 Gene


Suggested Antigen Peptide Sequences for YIPF2 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the YIP1 family.
  • Belongs to the YIP1 family.
genes like me logo Genes that share domains with YIPF2: view

Function for YIPF2 Gene

Gene Ontology (GO) - Molecular Function for YIPF2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 16189514
GO:0017137 Rab GTPase binding IBA --
genes like me logo Genes that share ontologies with YIPF2: view

Phenotypes for YIPF2 Gene

genes like me logo Genes that share phenotypes with YIPF2: view

Animal Model Products

  • Taconic Biosciences Mouse Models for YIPF2

Inhibitory RNA Products

Flow Cytometry Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for YIPF2 Gene

Localization for YIPF2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for YIPF2 Gene

Membrane; Multi-pass membrane protein.

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for YIPF2 gene
Compartment Confidence
golgi apparatus 4
plasma membrane 3
mitochondrion 2
nucleus 1

Gene Ontology (GO) - Cellular Components for YIPF2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005794 Golgi apparatus IBA --
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IEA --
GO:0030133 transport vesicle IDA --
genes like me logo Genes that share ontologies with YIPF2: view

Pathways & Interactions for YIPF2 Gene

SuperPathways for YIPF2 Gene

No Data Available

Gene Ontology (GO) - Biological Process for YIPF2 Gene


No data available for Pathways by source and SIGNOR curated interactions for YIPF2 Gene

Transcripts for YIPF2 Gene

Unigene Clusters for YIPF2 Gene

Yip1 domain family, member 2:
Representative Sequences:

Inhibitory RNA Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for YIPF2 Gene

ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5a · 5b · 5c ^ 6a · 6b ^ 7a · 7b ^ 8 ^ 9a · 9b · 9c
SP2: -

Relevant External Links for YIPF2 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for YIPF2 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for YIPF2 Gene

Protein differential expression in normal tissues from HIPED for YIPF2 Gene

This gene is overexpressed in Breast (37.9), Oral epithelium (14.3), and Placenta (7.6).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for YIPF2 Gene

NURSA nuclear receptor signaling pathways regulating expression of YIPF2 Gene:


SOURCE GeneReport for Unigene cluster for YIPF2 Gene:

genes like me logo Genes that share expression patterns with YIPF2: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein tissue co-expression partners and mRNA Expression by UniProt/SwissProt for YIPF2 Gene

Orthologs for YIPF2 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for YIPF2 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia YIPF2 34 35
  • 99.26 (n)
(Canis familiaris)
Mammalia YIPF2 34 35
  • 86.67 (n)
(Bos Taurus)
Mammalia YIPF2 34 35
  • 86.34 (n)
(Mus musculus)
Mammalia Yipf2 34 16 35
  • 79.76 (n)
(Rattus norvegicus)
Mammalia Yipf2 34
  • 79.59 (n)
(Ornithorhynchus anatinus)
Mammalia YIPF2 35
  • 74 (a)
(Monodelphis domestica)
Mammalia YIPF2 35
  • 61 (a)
(Anolis carolinensis)
Reptilia YIPF2 35
  • 56 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia Str.1767 34
(Danio rerio)
Actinopterygii yipf2 34 35
  • 55.78 (n)
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.2435 34
fruit fly
(Drosophila melanogaster)
Insecta CG4645 35
  • 26 (a)
(Caenorhabditis elegans)
Secernentea Y25C1A.7 35
  • 23 (a)
(Glycine max)
eudicotyledons Gma.739 34
sea squirt
(Ciona savignyi)
Ascidiacea -- 35
  • 37 (a)
Species where no ortholog for YIPF2 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for YIPF2 Gene

Gene Tree for YIPF2 (if available)
Gene Tree for YIPF2 (if available)

Paralogs for YIPF2 Gene

Paralogs for YIPF2 Gene

(1) SIMAP similar genes for YIPF2 Gene using alignment to 9 proteins:

genes like me logo Genes that share paralogs with YIPF2: view

Variants for YIPF2 Gene

Sequence variations from dbSNP and Humsavar for YIPF2 Gene

SNP ID Clin Chr 19 pos Sequence Context AA Info Type
rs10411918 -- 10,924,765(+) TCCCC(C/G)CACCC intron-variant
rs111975473 -- 10,926,834(+) TTTTC(G/T)ATTTT intron-variant, upstream-variant-2KB
rs112172158 -- 10,924,300(+) CACCT(C/T)GCCTG intron-variant
rs112215927 -- 10,930,279(+) TTTTT(G/T)TTTTT intron-variant, upstream-variant-2KB
rs112331241 -- 10,925,884(+) CCTGA(A/G)AGAAC intron-variant

Structural Variations from Database of Genomic Variants (DGV) for YIPF2 Gene

Variant ID Type Subtype PubMed ID
nsv833748 CNV loss 17160897
nsv833749 CNV loss 17160897

Variation tolerance for YIPF2 Gene

Residual Variation Intolerance Score: 97.3% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.96; 36.32% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for YIPF2 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for YIPF2 Gene

Disorders for YIPF2 Gene

MalaCards: The human disease database

(4) MalaCards diseases for YIPF2 Gene - From: DISEASES

Disorder Aliases PubMed IDs
tarsal-carpal coalition syndrome
  • tarsal carpal coalition syndrome
symphalangism, proximal, 1a
  • symphalangism, proximal, 1b
multiple synostoses syndrome
  • multiple synostosis syndrome
corneal dystrophy, posterior polymorphous, 1
  • corneal endothelial dystrophy 1, autosomal dominant
- elite association - COSMIC cancer census association via MalaCards
Search YIPF2 in MalaCards View complete list of genes associated with diseases

Relevant External Links for YIPF2

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
genes like me logo Genes that share disorders with YIPF2: view

No data available for UniProtKB/Swiss-Prot and Genatlas for YIPF2 Gene

Publications for YIPF2 Gene

  1. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4 64
  2. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg R.L. … Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002) 2 3 64
  3. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 3 64
  4. A proteome-scale map of the human interactome network. (PMID: 25416956) Rolland T. … Vidal M. (Cell 2014) 3 64
  5. N-terminal acetylome analyses and functional insights of the N- terminal acetyltransferase NatB. (PMID: 22814378) Van Damme P. … Aldabe R. (Proc. Natl. Acad. Sci. U.S.A. 2012) 4 64

Products for YIPF2 Gene

Sources for YIPF2 Gene

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