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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

YIPF2 Gene

protein-coding   GIFtS: 43
GCID: GC19M011033

Yip1 Domain Family, Member 2

  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Yip1 Domain Family, Member 21 2
YIP1 Family Member 22 3
FinGER22
Protein YIPF22

External Ids:    HGNC: 284761   Entrez Gene: 789922   Ensembl: ENSG000001307337   UniProtKB: Q9BWQ63   

Export aliases for YIPF2 gene to outside databases

Previous GC identifers: GC19M010895 GC19M010611


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

GeneCards Summary for YIPF2 Gene: 
YIPF2 (Yip1 domain family, member 2) is a protein-coding gene. Diseases associated with YIPF2 include denys-drash syndrome, and nephroblastoma. An important paralog of this gene is YIPF1.


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000019.9  NT_011295.11  NC_018930.2  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the YIPF2 gene promoter:
         NF-1   Elk-1   Pax-2   XBP-1   Pax-2a   c-Ets-1   Egr-4   PPAR-alpha   Ik-2   TGIF   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidYIPF2 promoter sequence
   Search SABiosciences Chromatin IP Primers for YIPF2

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat YIPF2


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 19p13.2   Ensembl cytogenetic band:  19p13.2   HGNC cytogenetic band: 19p13.2

YIPF2 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
YIPF2 gene location

GeneLoc information about chromosome 19         GeneLoc Exon Structure

GeneLoc location for GC19M011033:  view genomic region     (about GC identifiers)

Start:
11,033,444 bp from pter      End:
11,039,357 bp from pter
Size:
5,914 bases      Orientation:
minus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: YIPF2_HUMAN, Q9BWQ6 (See protein sequence)
Recommended Name: Protein YIPF2  
Size: 316 amino acids; 35151 Da
Subcellular location: Membrane; Multi-pass membrane protein (Potential)

Explore the universe of human proteins at neXtProt for YIPF2: NX_Q9BWQ6

Explore proteomics data for YIPF2 at MOPED 

Post-translational modifications:

  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_Q9BWQ6

  • YIPF2 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    YIPF2 Protein Expression
    REFSEQ proteins: NP_076934.1  
    ENSEMBL proteins: 
     ENSP00000466055   ENSP00000253031   ENSP00000467829   ENSP00000467156   ENSP00000465257  
     ENSP00000467019   ENSP00000466408   ENSP00000465943   ENSP00000468436   ENSP00000464839  

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    Novus Biologicals YIPF2 Lysate
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates 
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for YIPF2 

    Gene Ontology (GO): 3 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0016020membrane ----
    GO:0016021integral to membrane IEA--
    GO:0030133transport vesicle IDA--

    YIPF2 for ontologies           About GeneDecksing



    YIPF2 Antibody Products: 
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    Cloud-Clone Corp. ELISAs for YIPF2 
    Cloud-Clone Corp. CLIAs for YIPF2


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    HGNC Gene Families: 
    YIPF: Yip1 domain family

    1 InterPro protein domain:
     IPR006977 Yip1

    Graphical View of Domain Structure for InterPro Entry Q9BWQ6

    ProtoNet protein and cluster: Q9BWQ6

    UniProtKB/Swiss-Prot: YIPF2_HUMAN, Q9BWQ6
    Similarity: Belongs to the YIP1 family


    YIPF2 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Animal Models:
       inGenious Targeting Laboratory - Custom generated mouse model solutions for YIPF2 
       inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for YIPF2

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for YIPF2 
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for YIPF2 

    miRNA
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    SwitchGear 3'UTR luciferase reporter plasmidYIPF2 3' UTR sequence
    Inhib. RNA
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    Browse for Gene Knock-down Tools from EMD Millipore
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    Gene Editing
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    Clone
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                         Customized lentivirus expression plasmids for stable overexpression of YIPF2 

    Cell Line
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    In Situ Assay
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for YIPF2


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section



    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for YIPF2

    STRING Interaction Network Preview (showing 2 interactants - click image to see more details)

    3 Interacting proteins for YIPF2 (Q9BWQ63 ENSP000002530314) via UniProtKB, MINT, STRING, and/or I2D
    InteractantInteraction Details
    GeneCardExternal ID(s)
    YIPF6Q96EC83, ENSP000004175734I2D: score=2 STRING: ENSP00000417573
    FATE1Q969F03I2D: score=1 
    ELAVL1ENSP000003852694STRING: ENSP00000385269
    About this table

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for YIPF2

    Search CenterWatch for drugs/clinical trials and news about YIPF2

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for YIPF2 gene: 
    NM_024029.3  

    Unigene Cluster for YIPF2:

    Yip1 domain family, member 2
    Hs.720136  [show with all ESTs]
    Unigene Representative Sequence: NM_024029
    12 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000586748 ENST00000253031(uc002mqb.3 uc002mqc.3) ENST00000592646
    ENST00000589971 ENST00000591872 ENST00000590329 ENST00000586575 ENST00000587943
    ENST00000588347 ENST00000585858 ENST00000588962 ENST00000592505
    miRNA
    Products:
         
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat YIPF2
    8/10 QIAGEN miScript miRNA Assays for microRNAs that regulate YIPF2 (see all 10):
    hsa-miR-448 hsa-miR-34b* hsa-miR-4328 hsa-miR-324-3p hsa-miR-410 hsa-miR-153 hsa-miR-146a* hsa-miR-548t
    SwitchGear 3'UTR luciferase reporter plasmidYIPF2 3' UTR sequence
    Inhib. RNA
    Products:
         
    Browse for Gene Knock-down Tools from EMD Millipore
    OriGene RNAi products in human, mouse, rat for YIPF2
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat YIPF2
    Clone
    Products:
         
    OriGene clones in human, mouse for YIPF2 (see all 8)
    OriGene ORF clones in mouse, rat for YIPF2
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: YIPF2 (NM_024029)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for YIPF2
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat YIPF2
    Sirion Biotech Customized lentivirus for stable overexpression of YIPF2 
                         Customized lentivirus expression plasmids for stable overexpression of YIPF2 
    Primer
    Products:
        
    OriGene qPCR primer pairs and template standards for YIPF2
    OriGene qSTAR qPCR primer pairs in human, mouse for YIPF2
    SABiosciences RT2 qPCR Primer Assay in human, mouse, rat YIPF2
      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat YIPF2
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat YIPF2

    Additional mRNA sequence: 

    BC000056.2 BC013014.2 

    16 DOTS entries:

    DT.100883374  DT.97775761  DT.100883380  DT.100883383  DT.220742  DT.85104699  DT.100661719  DT.100883379 
    DT.100883375  DT.100709504  DT.100681577  DT.100883361  DT.91765876  DT.91765885  DT.97855193  DT.100686557 

    24/245 AceView cDNA sequences (see all 245):

    BE391217 BQ928568 BM910511 BX332273 AW089873 AI660225 BQ067455 BQ678064 
    BM975967 BE407247 BU858010 CN483950 BM682976 BU753892 BU860186 AI659144 
    BX482998 AI338240 CA413410 BX387531 CR601786 BI713049 NM_024029 BQ676152 

    GeneLoc Exon Structure

    5 Alternative Splicing Database (ASD) splice patterns (SP) for YIPF2    About this scheme

    ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5a · 5b · 5c ^ 6a · 6b ^ 7a · 7b ^ 8 ^ 9a · 9b · 9c
    SP1:                                                                                          
    SP2:                                            -                                             
    SP3:                                                                                          
    SP4:                                                                                          
    SP5:                                                                                          


    ECgene alternative splicing isoforms for YIPF2

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    YIPF2 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: GGCTGTAAGT
    YIPF2 Expression
    About this image


    See YIPF2 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for YIPF2

    SOURCE GeneReport for Unigene cluster: Hs.720136
        SABiosciences Custom PCR Arrays for YIPF2
    Primer
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    QIAGEN QuantiFast Probe-based Assays in human, mouse, rat YIPF2
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for YIPF2

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of eukaryotes.

    Orthologs for YIPF2 gene from 8/18 species (see all 18)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Yipf21 , 5 Yip1 domain family, member 21, 5 79.76(n)1
    82.47(a)1
      9 (7.83 cM)5
    747661  NM_001205157.11  NP_001192086.11 
     215887095 
    lizard
    (Anolis carolinensis)
    Reptilia YIPF26
    Yip1 domain family, member 2
    53(a)
    1 ↔ 1
    2(80878265-80894452)
    African clawed frog
    (Xenopus laevis)
    Amphibia BU910210.12   -- 76.06(n)    BU910210.1 
    zebrafish
    (Danio rerio)
    Actinopterygii yipf21 Yip1 domain family, member 2 56.31(n)
    52.7(a)
      445106  NM_001003500.1  NP_001003500.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta CG46456
    --
    26(a)
    1 → many
    X(12803986-12805948)
    worm
    (Caenorhabditis elegans)
    Secernentea Y25C1A.76
    Protein Y25C1A.7, isoform c
    21(a)
    1 → many
    II(3062540-3071381)
    thale cress
    (Arabidopsis thaliana)
    eudicotyledons AT2G398051 Integral membrane Yip1 family protein 44.55(n)
    35.61(a)
      818567  NM_179991.2  NP_850322.1 
    rice
    (Oryza sativa)
    Liliopsida Os05g04558001 hypothetical protein 43.74(n)
    35.02(a)
      4338982  NM_001062261.1  NP_001055726.1 


    ENSEMBL Gene Tree for YIPF2 (if available)
    TreeFam Gene Tree for YIPF2 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for YIPF2 gene
    YIPF12  
    1 SIMAP similar gene for YIPF2 using alignment to 9 protein entries:     YIPF2_HUMAN (see all proteins):
    YIPF1

    YIPF2 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/256 SNPs in YIPF2 are shown (see all 256)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 19 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1906175901,2
    C--10969773(+) GCCCCA/GCCGAG 1 -- int10--------
    rs129728751,2
    C--10969776(+) CCGCCA/GAGGCT 1 -- int10--------
    rs1829046361,2
    --10969917(+) CCCCCA/GCCCCC 1 -- int10--------
    rs1995723331,2
    C--10969935(+) AGAGT-/AGAGCA 1 -- int10--------
    rs1878762581,2
    --10970221(+) GCAGCA/GCAGGC 1 -- ut310--------
    rs1918749891,2
    --10970296(+) CCGCCA/GTGTGT 1 -- ut310--------
    rs1829807301,2
    C--10970453(+) CCCTCG/TCCCGC 1 -- ut310--------
    rs1876562031,2
    --10970457(+) CGCCCA/GCCTTT 1 -- ut310--------
    rs1925174271,2
    --10970526(+) AGTCTA/GGAAAG 1 -- ut310--------
    rs1853887121,2
    --10970669(+) CTTGAC/GTGGGA 1 -- int10--------

    HapMap Linkage Disequilibrium report for YIPF2 (11033444 - 11039357 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 4 variations for YIPF2:    About this table     
    Variant IDTypeSubtypePubMed ID
    nsv911050CNV Loss21882294
    nsv911051CNV Loss21882294
    nsv833749CNV Loss17160897
    nsv833748CNV Loss17160897

    SABiosciences Cancer Mutation PCR Assays
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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    2 diseases for YIPF2:    About MalaCards
    denys-drash syndrome    nephroblastoma

    2 diseases from the University of Copenhagen DISEASES database for YIPF2:
    Denys-Drash syndrome     Nephroblastoma

    YIPF2 for disorders           About GeneDecksing


    Export disorders for YIPF2 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for YIPF2 gene integrated from 9 sources:
    (articles sorted by number of sources associating them with YIPF2)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    2. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1, 3 Strausberg R.L....Marra M.A. (2002)
    3. Ubiquitin-mediated proteolysis of HuR by heat shock. (PubMed id 19322201)1 Abdelmohsen K....Gorospe M. (2009)
    4. The LIFEdb database in 2006. (PubMed id 16381901)1 Mehrle A....Wiemann S. (2006)
    5. Towards a proteome-scale map of the human protein-protein interaction network. (PubMed id 16189514)1 Rual J.F....Vidal M. (2005)
    6. From ORFeome to biology: a functional genomics pipeline. (PubMed id 15489336)1 Wiemann S....Poustka A. (2004)
    7. Systematic subcellular localization of novel proteins identified by large-scale cDNA sequencing. (PubMed id 11256614)1 Simpson J.C.... Wiemann S. (2000)
    8. DNA cloning using in vitro site-specific recombination. (PubMed id 11076863)1 Hartley J.L....Brasch M.A. (2000)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 78992 HGNC: 28476 AceView: MGC3262 Ensembl:ENSG00000130733 euGenes: HUgn78992
    ECgene: YIPF2 H-InvDB: YIPF2

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for YIPF2 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for YIPF2 gene:
    Search GeneIP for patents involving YIPF2

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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    About This Section

     
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    GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 4 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

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