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YIPF1 Gene

protein-coding GIFtS: 47

GC01M054030

Yip1 domain family, member 1
Symbol approved by the HUGO Gene Nomenclature Committee (HGNC) database

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc , and/or ⁷Ensembl, ⁸miRBase)
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Aliases
DJ167A19.1 ^¹, ²
FinGER1 ^¹, ²

Descriptions
YIP1 family member 1 ^³
Yip1 domain family, member 1 ^²

External Ids
HGNC: 25231¹
Entrez Gene: 54432²
UniProtKB: Q9Y548³
Ensembl: ENSG00000058799⁷

Search outside databases for aliases for YIPF1 gene

(According to Entrez Gene, Wikipedia's Gene Wiki,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Gene Wiki entry for YIPF1

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 36),
and/or miRBase,
Genomic Views according to UCSC and Ensembl, Transcription factor binding sites according to SABiosciences)
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Genomic View:

UCSC Golden Path with GeneCards custom track

Transcription factor binding sites upstream to the YIPF1 gene

Entrez Gene cytogenetic band: 1p33-p32.1 Ensembl cytogenetic band: 1p32.3 HGNC cytogenetic band: 1p33-p32.1

YIPF1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)

GeneLoc gene densities for chromosome 1 GeneLoc Exon Structure

GeneLoc location for GC01M054030: (about GC identifiers)

Start:	54,089,994 bp from pter
End:	54,128,041 bp from pter
Size:	38,048 bases
Orientation:	minus strand

RefSeq DNA sequence:

NC_000001.9 NT_032977.8

(According to ¹UniProtKB, and/or Ensembl, Phosphorylation sites according to ²Phosphosite, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Enzo Life Sciences, Abnova, OriGene and/or, Abcam,
Biochemical Assays by Invitrogen, Millipore, R&D Systems, Cell Signaling Technology, and/or Enzo Life Sciences, Ontologies according to Gene Ontology Consortium 01 Apr 2009 and Entrez Gene, Antibodies by Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Cell Signaling Technology, Abcam, Abnova, and/or Novus Biologicals)
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UniProtKB/Swiss-Prot: YIPF1_HUMAN, Q9Y548 (See protein sequence)

Recommended Name: Protein YIPF1

Size: 306 amino acids; 34277 Da

Subcellular location: Membrane; Multi-pass membrane protein (Potential)

Secondary accessions: Q9NWJ1

Alternative splicing: 2 isoforms: Q9Y548-1 Q9Y548-2

REFSEQ proteins: NP_061855.1

ENSEMBL proteins:

ENSP00000360452 ENSP00000072644

Human Recombinant Proteins

	Browse Drug Discovery Central at Invitrogen for human recombinant proteins
	Browse Purified and Recombinant Proteins at Millipore
	Browse Human Recombinant Proteins at Sigma-Aldrich
	Browse R&D Systems for human recombinant proteins
	Browse recombinant and purified proteins available from Enzo Life Sciences
	Recombinant Proteins from Abcam (YIPF1)
	Browse Abnova for Human Recombinant Proteins

Browse Origene for full length recombinant human proteins expressed in human HEK293 cells

3 Gene Ontology (GO) cellular component terms (links to tree view):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0016020	membrane	IEA	--
GO:0016021	integral to membrane	IEA	--
GO:0030133	transport vesicle	IDA	11256614

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Antibodies for YIPF1:

	Browse Antibodies Central at Invitrogen
	Browse Millipore's Extensive Line of Mono- and Polyclonal Antibodies
	Sigma-Aldrich Antibodies for YIPF1
	Browse R&D Systems for Antibodies
	Antibodies from Abcam (YIPF1), each with their Abpromise^SM
	Browse Abnova for Monoclonal and Polyclonal Antibodies
	Search Novus for antibodies for YIPF1

Assays for YIPF1:

	Browse Invitrogen for biochemical assays
	Browse Kits and Assays available from Millipore
	Browse R&D Systems for biochemical assays
	Browse biochemical assays available from Enzo Life Sciences

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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Graphical View of Domain Structure for InterPro Entry Q9Y548

ProtoNet protein and cluster: Q9Y548

UniProtKB/Swiss-Prot: YIPF1_HUMAN, Q9Y548

Similarity: Belongs to the YIP1 family

(According to MGI Jun 06 2009, UniProtKB, IUBMB,and/or Genatlas,
shRNA from OriGene, Sigma-Aldrich, RNAi from Sigma-Aldrich,
RNAi Products, Clones, and Q-PCR Products from Invitrogen, Millipore, OriGene, and/or Abnova, siRNAs from Applied Biosystems, SYBR primers from OriGene, Cell-based Assays from Millipore, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
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Inhib. RNA:		Invitrogen RNAi Products for gene knock-down (YIPF1)
		Browse for Gene Knock-down Tools from Millipore
		Browse Abnova for Chimera RNAi Products

OriGene 29mer shRNA kit in GFP-retroviral vector: NM_018982

Applied Biosystems Silencer® siRNAs for YIPF1

Sigma-Aldrich siRNA for YIPF1

Sigma-Aldrich shRNA for YIPF1

Explore Sigma-Aldrich super-pooled esiRNAs

Clones:		Invitrogen Clones for YIPF1
		Browse Clones for the Expression of Recombinant Proteins Available from Millipore

OriGene GFP tagged cDNA clone in CMV expression vector: NM_018982
Myc/DDK tagged cDNA clone in CMV expression vector: NM_018982
untagged cDNA clone in CMV expression vector: NM_018982

Primers:

Browse Quantitative PCR Central at Invitrogen for Q-PCR LUX™ Primers

OriGene genome-wide validated SYBR primer pairs: NM_018982

(Pathways according to Invitrogen (maps by GeneGo), Millipore, Cell Signaling Technology, Sigma-Aldrich, KEGG and/or UniProtKB,
Sets of similar genes according to GeneDecks, Proteins Network according to SABiosciences, Interactions according to ¹UniProtKB, ²MINT, and/or ³STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
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5/8 Interacting proteins for YIPF1 (ENSP00000072644³) via UniProtKB, MINT, and/or STRING (see all 8 )

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
FBXO32	ENSP00000287396³	STRING (score=.901)
TTN	ENSP00000340554³	STRING (score=.877)
PRKCA	ENSP00000284384³	STRING (score=.861)
FOXO3	ENSP00000339527³	STRING (score=.772)
MGRN1	ENSP00000262370³	STRING (score=.755)

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(Chemical Compounds according to UniProtKB, Enzo Life Sciences, Sigma-Aldrich, Tocris Bioscience, and/or Novoseek and Drugs according to Enzo Life Sciences and/or PharmGKB)
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Browse drugs & compounds from Enzo Life Sciences

Browse Small Molecules at Sigma-Aldrich

Browse Tocris compounds for YIPF1

(GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 219 Homo sapiens; Jun 2 2009) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView,
non coding RNAs according to RNAdb,
ESTs according to GeneTide,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from Invitrogen, Millipore, and/or Abnova,
siRNAs from Applied Biosystems, Sigma-Aldrich,
shRNA from Sigma-Aldrich, OriGene,
Tagged/untagged cDNA clones from OriGene,
Expression Assays from Applied Biosystems)
About This Section

Inhib. RNA:		Invitrogen RNAi Products for gene knock-down (YIPF1)
		Browse for Gene Knock-down Tools from Millipore
		Browse Abnova for Chimera RNAi Products

OriGene 29mer shRNA kit in GFP-retroviral vector: NM_018982

Sigma-Aldrich siRNA for YIPF1

Sigma-Aldrich shRNA for YIPF1

Explore Sigma-Aldrich super-pooled esiRNAs

Applied Biosystems Silencer® siRNAs:

NM_018982

REFSEQ mRNAs for YIPF1 gene:

NM_018982.3

Applied Biosystems TaqMan ® Gene Expression Assays:

NM_018982

              OriGene GFP tagged cDNA clone in CMV expression vector: NM_018982
                                 Myc/DDK tagged cDNA clone in CMV expression vector: NM_018982
                                 untagged cDNA clone in CMV expression vector: NM_018982

Additional cDNA sequence:

AK000823.1 AK300240.1 AK315183.1 AL713668.1 BC009674.1 BC064590.1 CR595743.1 CR601785.1

CR602343.1 CR612966.1 CR615001.1 CR621847.1 CR623623.1 CR624867.1

13 DOTS entries:

DT.92437172 DT.100782964 DT.100782957 DT.100782959 DT.92437173 DT.100782961 DT.121370361 DT.92437176

DT.95126675 DT.95126680 DT.95263009 DT.92437174 DT.99970827

24/190 AceView cDNA sequences (see all 190 ):

CR615001 BM756401 CR601785 BG387679 AL558899 CR602343 BM760141 BM760914

CR612966 CR624867 CR623623 BG742307 BM752394 CB159366 BM474869 BI916236

BM760117 CR621847 BQ424022 AW601956 BM919571 BQ654320 CA412152 AA778928

highest scoring ESTs for YIPF1:

AA354863 AK000823 AL549408 AL551031 AL713668 BC064590 BE789873 BF686451 BF971376 BG338987

Unigene Cluster for YIPF1:

Yip1 domain family, member 1

Hs.11923 [show with all ESTs]

Unigene Representative Sequence: BC064590

GeneLoc Exon Structure

5/9 Alternative Splicing Database (ASD) splice patterns (SP) for YIPF1 (see all 9 )

ExUns:	1a	·	1b	^	2	^	3	^	4	^	5a	·	5b	^	6a	·	6b	^	7	^	8	^	9	^	10a	·	10b	^	11a	·	11b	·	11c	^	12	^	13	^	14a	·	14b
SP1:									-						-		-																				-
SP2:					-		-		-						-		-																				-
SP3:					-				-						-		-
SP4:					-		-								-		-
SP5:					-				-

About this scheme

ECgene alternative splicing isoforms for YIPF1

2 Ensembl transcripts including schematic representations:

ENST00000371399 ENST00000072644

(Experimental results according to ¹GeneNote and GNF BioGPS,
probe sets-to-genes annotations according to ²GeneAnnot , ³GeneTide , Sets of similar genes according to GeneDecks, Electronic Northern calculations according to data from UniGene (Build 219 Homo sapiens), SAGE tags according to CGAP, plus additional links to SOURCE, and/or GNF BioGPS, and/or EXPOLDB, and/or UniProtKB,
Expression Assays from Applied Biosystems )
About This Section

YIPF1 expression in normal and diseased human tissues

Applied Biosystems TaqMan ® Gene Expression Assays for YIPF1

¹ / ² / ³

3 probe-sets matching YIPF1 gene

Affymetrix probe-set	Array	# genes	Sensitivity	Specificity	Correlation	Length	Gb_Accession	Consensus	Uniqueness	Score	Rank
Affymetrix probe-set	Array	GeneAnnot data			GeneNote data		GeneTide data
41640_at²^{, 3}	U95-A	1	1.00	1.00	1.00	1.00	AL031427	0.20	0.33	0.27	1
214733_s_at²^{, 3}	U133-A	1	1.00	1.00	--	--	AL031427	0.20	0.33	0.27	1
214733_s_at²	U133Plus2	1	1.00	1.00	--	--	--	--	--	--	--

GeneDecks YIPF1 for binary patterns associated with the probe-sets selected above

About GeneDecksing

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Data from

(Publications) and GNF BioGPS
About these images
About these images

CGAP SAGE TAG: CTTCACTGTG

SOURCE GeneReport for Unigene cluster: Hs.11923

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD and/or ⁵MGI Jun 06 2009, with possible further links to Flybase and/or WormBase, Gene Trees according to Ensembl)
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Orthologs for YIPF1 gene from 5/16 species (see all 16 )

Organism	Gene	Locus	Description	Human Similarity	NCBI accessions
dog (Canis familiaris)	YIPF1¹	--	Yip1 domain family, member 1	92.21(n) 93.42(a)	489581 XM_546701.2 XP_546701.2
chimpanzee (Pan troglodytes)	YIPF1¹	--	Yip1 domain family, member 1	99.78(n) 99.67(a)	738392 XM_001148917.1 XP_001148917.1
cow (Bos taurus)	YIPF1¹	--	Yip1 domain family, member 1	90.96(n) 92.81(a)	511748 XM_875653.2 XP_880746.1
rat (Rattus norvegicus)	Yipf1¹	--	Yip1 domain family, member 1	84.2(n) 88.56(a)	298312 NM_199383.1 NP_955415.1
mouse (Mus musculus)	Yipf1^{1, 5}	4⁵	Yip1 domain family, member 1^{1, 5}	83.77(n)¹ 87.58(a)¹	230584¹ NM_145550.2¹ NP_663525.1¹ AA547495⁵ AI413160⁵ (see all 16)

About this table Species with no ortholog for YIPF1

ENSEMBL Gene Tree for YIPF1

(Paralogs according to ¹HomoloGene
and ²Ensembl, Pseudogenes according to ³Pseudogene.org)
About This Section

Paralogs for YIPF1 gene

YIPF2²

(According to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, and UniProtKB, Linkage Disequilibrium by HapMap, Genotyping Reagents from Applied Biosystems)
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10/230 NCBI SNPs in YIPF1 are shown (see all 230 )
(Click for Applied Biosystems TaqMan ® Genotyping Assay) (see all 89)

AB	SNP ID	Valid	Chr 1 pos	Sequence	Recs	AA Chg	Type	More	Recs	Pop	Total sample	More
AB	Genomic Data				Transcription Data				Allele Frequencies
				--	--	--		--	--			--
	rs3817871^1,2	A,C,F,H	54127523(+)	`AGAGAG/CCAGGT`	1	--	ut5¹ ese³		12	EA NA EU WA	2386
	rs10888814^1,2	A,C,F,H	54127629(+)	`GTTAAA/GGGCAC`	1	--	ut5¹		4	EU EA WA	412
	rs6702765^1,2	A,C,F,H	54128531(+)	`TGAGCG/ACTTGG`	1	--	ng3¹		6	NA EA WA	376
	rs6682112^1,2	A,C,F,H	54128929(+)	`TTCTTC/GATGCG`	1	--	ng3¹		4	EU EA WA	406
	rs2272931^1,2	A,C,F,H	54128428(+)	`GGCCAC/TAAAAA`	1	--	ng3¹		9	EU EA WA NA	843
--	rs6656722^1,2	A,C,F,H	54128694(+)	`TTAGAG/ACATGT`	1	--	ng3¹		4	EU EA WA	412
	rs11206237^1,2	A,C,F,H	54128949(+)	`TGGGAC/ACTTGC`	1	--	ng3¹ tfbs³		12	EU EA WA	1256
	rs1127931^1,2	C,F,H	54090073(-)	`TTAACC/TGGGAG`	1	--	ut3¹		13	MN EU EA WA	1430
	rs1127922^1,2	A,C,H	54090285(-)	`ATGCCG/AGGGAA`	1	--	ut3¹ ese³		3	EU EA	296
--	rs2294508^1,2	A,C,F	54127246(+)	`CAGGGT/GTCTAA`	1	--	ut5¹ ese³		3	NA	138

About this table

HapMap Linkage Disequilibrium images for YIPF1 (up to first 250kb)

(in which this Gene is Involved, According to OMIM, UniProtKB, PharmGKB, Genatlas, GeneTests, Blood group antigen gene mutations by BGMUT, HGMD, GAD, HuGE Navigator, BCGD, and/or TGDB.)
About This Section

(Possibly Related Articles in Doctor's Guide)
About This Section

(in PubMed. Associations of this gene to articles via ¹Novoseek, ²HGNC, ³Entrez Gene, ⁴UniProtKB/Swiss-Prot, ⁵UniProtKB/TrEMBL, ⁶GAD, and/or ⁷PharmGKB)
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10 PubMed articles for YIPF1 gene:

The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)^{3, 4} Gerhard D.S....Malek J. (2004)
Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)^{3, 4} Ota T....Sugano S. (2004)
Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)^{2, 3} Strausberg R.L....Marra M.A. (2002)
The full-ORF clone resource of the German cDNA Consortium. (PubMed id 17974005)⁴ Bechtel S....Schupp I. (2007)
The LIFEdb database in 2006. (PubMed id 16381901)³ Mehrle A....Wiemann S. (2006)
High-content screening microscopy identifies novel proteins with a putative role in secretory membrane traffic. (PubMed id 15466293)³ Starkuviene V....Pepperkok R. (2004)
From ORFeome to biology: a functional genomics pipeline. (PubMed id 15489336)³ Wiemann S....Poustka A. (2004)
Towards a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs. (PubMed id 11230166)³ Wiemann S.... Poustka A. (2001)
Systematic subcellular localization of novel proteins identified by large-scale cDNA sequencing. (PubMed id 11256614)³ Simpson J.C.... Wiemann S. (2000)
DNA cloning using in vitro site-specific recombination. (PubMed id 11076863)³ Hartley J.L....Brasch M.A. (2000)

(in PubMed, OMIM, and NCBI Bookshelf)
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		AND	OR
Aliases
Free Text

Query String		PubMed OMIM NCBI Bookshelf
	(Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, and/or H-InvDB)
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Entrez Gene: 54432	HGNC: 25231	AceView: DJ167A19.1	Ensembl:ENSG00000058799	euGenes: HUgn54432
ECgene: YIPF1	H-InvDB: YIPF1

(According to HUGE)
About This Section

(According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
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Licensable Technologies for YIPF1
(Available from WIS Yeda, Salk, Tufts)

About This Section

(Reagents available from Applied Biosystems, Antibodies and assays by Cell Signaling Technology, Abcam, Novus Biologicals,
Sigma-Aldrich, R&D Systems, Millipore, Abnova, and/or Invitrogen, Clones available from OriGene,and/or Invitrogen, Drugs and/or compounds by Sigma-Aldrich,
Enzo Life Sciences, and/or Tocris Bioscience)
About This Section

Products for YIPF1:

TaqMan ® Gene Expression Assays

TaqMan ® Genotyping Assays

Free SNP selection tool

Invitrogen iPath Pathways	Invitrogen BLOCK-iT™ RNAi
Invitrogen Antibodies	Invitrogen Assays
Invitrogen Clones	Invitrogen Q-PCR Products
Invitrogen Human Recombinant Kinases	Invitrogen Custom Antibody and Peptide Service
Invitrogen Proteins / Assays / Screening Services	Search Invitrogen catalog for YIPF1-related products

	Millipore Custom Antibody & Bulk Services
	Millipore Preclinical / Clinical Development Services
	Millipore Immunoassay Services
	Millipore Target Screening & Profiling Services

	Predesigned and custom siRNAs for YIPF1		Antibodies for YIPF1
	Explore super-pooled esiRNAs		Browse proteins at Sigma-Aldrich
	Lentivirus-delivered shRNAs for YIPF1		Browse small molecules at Sigma-Aldrich
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YIPF1 Gene

protein-coding GIFtS: 47

Aliases &
Descriptions
for YIPF1

Summaries
for YIPF1

Genomic Location
for YIPF1

Proteins
for YIPF1

Protein Domains/
Families
for YIPF1

Gene Function
for YIPF1

Pathways & Interactions
for YIPF1

Drugs & Compounds
for YIPF1

Transcripts
for YIPF1

Expression
for YIPF1

Orthologs
for YIPF1

Paralogs
for YIPF1

SNPs/Variants
for YIPF1

Disorders & Mutations
for YIPF1

Medical News
for YIPF1

Publications
for YIPF1

Search for YIPF1

Genome Databases showing YIPF1

Other Databases showing YIPF1

Specialized Databases showing YIPF1

Licensable Technologies
for YIPF1

Services
for YIPF1

Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

YIPF1 Gene

protein-coding GIFtS: 47

Aliases & Descriptionsfor YIPF1

Summariesfor YIPF1

Genomic Locationfor YIPF1

Proteinsfor YIPF1

Protein Domains/Familiesfor YIPF1

Gene Functionfor YIPF1

Pathways & Interactionsfor YIPF1

Drugs & Compoundsfor YIPF1

Transcriptsfor YIPF1

Expression for YIPF1

Orthologsfor YIPF1

Paralogsfor YIPF1

SNPs/Variantsfor YIPF1

Disorders & Mutationsfor YIPF1

Medical Newsfor YIPF1

Publicationsfor YIPF1

Search for YIPF1

Genome Databases showing YIPF1

Other Databases showing YIPF1

Specialized Databases showing YIPF1

Licensable Technologiesfor YIPF1

Servicesfor YIPF1

Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

Aliases &
Descriptions
for YIPF1

Summaries
for YIPF1

Genomic Location
for YIPF1

Proteins
for YIPF1

Protein Domains/
Families
for YIPF1

Gene Function
for YIPF1

Pathways & Interactions
for YIPF1

Drugs & Compounds
for YIPF1

Transcripts
for YIPF1

Expression
for YIPF1

Orthologs
for YIPF1

Paralogs
for YIPF1

SNPs/Variants
for YIPF1

Disorders & Mutations
for YIPF1

Medical News
for YIPF1

Publications
for YIPF1

Licensable Technologies
for YIPF1

Services
for YIPF1