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Aliases for YIPF1 Gene

Aliases for YIPF1 Gene

  • Yip1 Domain Family Member 1 2 3 5
  • YIP1 Family Member 1 3 4
  • Yip1 Domain Family, Member 1 2
  • Protein YIPF1 3
  • DJ167A19.1 3
  • FinGER1 3

External Ids for YIPF1 Gene

Previous GeneCards Identifiers for YIPF1 Gene

  • GC01M054030
  • GC01M054317
  • GC01M052433

Summaries for YIPF1 Gene

GeneCards Summary for YIPF1 Gene

YIPF1 (Yip1 Domain Family Member 1) is a Protein Coding gene. Diseases associated with YIPF1 include De Quervain Disease. GO annotations related to this gene include RNA binding and ribonuclease activity. An important paralog of this gene is YIPF2.

Gene Wiki entry for YIPF1 Gene

No data available for Entrez Gene Summary , CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for YIPF1 Gene

Genomics for YIPF1 Gene

Regulatory Elements for YIPF1 Gene

Enhancers for YIPF1 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH01G053981 1.2 Ensembl ENCODE 11 -92.8 -92776 1.6 ELF3 TBP ARID4B DMAP1 ZNF48 RAD21 RARA YY1 THAP11 SMARCA5 TCEANC2 HSPB11 LRRC42 LDLRAD1 YIPF1 DIO1 TMEM59 HNRNPA3P12 GC01P054015
GH01G053910 0.9 ENCODE 13.2 -20.3 -20289 0.2 HDGF HDAC1 FOXA2 CREB3L1 RAD21 RARA TCF12 GLIS2 ZNF766 GATA2 YIPF1 HSPB11 LRRC42 RPL37P7 NDC1 LDLRAD1 TCEANC2 TMEM59 RNU7-95P GC01P053910
GH01G053918 0.8 ENCODE 12.4 -29.2 -29185 1.1 ELF3 CTCF SOX13 FOXA2 SAP130 CEBPG ZNF644 YY1 TEAD3 ZNF121 HSPB11 LRRC42 DIO1 YIPF1 RPL37P7 NDC1 LDLRAD1 RNU7-95P GC01P053910 GC01P053939
GH01G053892 1.1 FANTOM5 Ensembl ENCODE 8.5 -3.0 -3005 1.4 ZFHX2 MAX MNT REST EGR2 DIO1 YIPF1 ENSG00000230953 GC01P053910
GH01G053860 0.7 ENCODE 11.6 +28.8 28772 0.2 CTCF RB1 TSC22D4 ARID4B RAD21 FOXK2 SCRT2 ZNF143 SMC3 ZNF652 LRRC42 HSPB11 YIPF1 DIO1 RPL37P7 GC01P053890
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around YIPF1 on UCSC Golden Path with GeneCards custom track

Promoters for YIPF1 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000006571 134 1401 HDGF PKNOX1 ARNT AGO1 ARID4B SIN3A ZNF2 SLC30A9 ZNF143 ZNF207

Genomic Location for YIPF1 Gene

Chromosome:
1
Start:
53,849,790 bp from pter
End:
53,889,834 bp from pter
Size:
40,045 bases
Orientation:
Minus strand

Genomic View for YIPF1 Gene

Genes around YIPF1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
YIPF1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for YIPF1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for YIPF1 Gene

Proteins for YIPF1 Gene

  • Protein details for YIPF1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9Y548-YIPF1_HUMAN
    Recommended name:
    Protein YIPF1
    Protein Accession:
    Q9Y548
    Secondary Accessions:
    • B2RCM7
    • D3DQ40
    • Q9NWJ1

    Protein attributes for YIPF1 Gene

    Size:
    306 amino acids
    Molecular mass:
    34277 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=AAH09674.1; Type=Erroneous initiation; Evidence={ECO:0000305};

    Alternative splice isoforms for YIPF1 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for YIPF1 Gene

Post-translational modifications for YIPF1 Gene

  • Ubiquitination at Lys63 and Lys107
  • Glycosylation at Asn297
  • Modification sites at PhosphoSitePlus

Other Protein References for YIPF1 Gene

No data available for DME Specific Peptides for YIPF1 Gene

Domains & Families for YIPF1 Gene

Gene Families for YIPF1 Gene

Protein Domains for YIPF1 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for YIPF1 Gene

Graphical View of Domain Structure for InterPro Entry

Q9Y548

UniProtKB/Swiss-Prot:

YIPF1_HUMAN :
  • Belongs to the YIP1 family.
Family:
  • Belongs to the YIP1 family.
genes like me logo Genes that share domains with YIPF1: view

Function for YIPF1 Gene

Gene Ontology (GO) - Molecular Function for YIPF1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 25416956
GO:0017137 Rab GTPase binding IBA --
genes like me logo Genes that share ontologies with YIPF1: view
genes like me logo Genes that share phenotypes with YIPF1: view

Animal Models for YIPF1 Gene

MGI Knock Outs for YIPF1:

Animal Model Products

CRISPR Products

miRNA for YIPF1 Gene

miRTarBase miRNAs that target YIPF1

Inhibitory RNA Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for YIPF1 Gene

Localization for YIPF1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for YIPF1 Gene

Membrane; Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for YIPF1 gene
Compartment Confidence
plasma membrane 3
nucleus 3
golgi apparatus 3
cytoskeleton 1
mitochondrion 1
peroxisome 1
endoplasmic reticulum 1
cytosol 1
lysosome 1
endosome 1

Gene Ontology (GO) - Cellular Components for YIPF1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005794 Golgi apparatus IBA --
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IEA --
GO:0030133 transport vesicle IDA --
genes like me logo Genes that share ontologies with YIPF1: view

Pathways & Interactions for YIPF1 Gene

SuperPathways for YIPF1 Gene

No Data Available

Interacting Proteins for YIPF1 Gene

Gene Ontology (GO) - Biological Process for YIPF1 Gene

None

No data available for Pathways by source and SIGNOR curated interactions for YIPF1 Gene

Drugs & Compounds for YIPF1 Gene

No Compound Related Data Available

Transcripts for YIPF1 Gene

Unigene Clusters for YIPF1 Gene

Yip1 domain family, member 1:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Alternative Splicing Database (ASD) splice patterns (SP) for YIPF1 Gene

ExUns: 1a · 1b ^ 2 ^ 3 ^ 4 ^ 5a · 5b ^ 6a · 6b ^ 7 ^ 8 ^ 9 ^ 10a · 10b ^ 11a · 11b · 11c ^ 12 ^ 13 ^ 14a · 14b
SP1: - - - -
SP2: - - - - - -
SP3: - - - -
SP4: - - - -
SP5: - -
SP6:
SP7: - - - - -
SP8: - - - -
SP9: -

Relevant External Links for YIPF1 Gene

GeneLoc Exon Structure for
YIPF1
ECgene alternative splicing isoforms for
YIPF1

Expression for YIPF1 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for YIPF1 Gene

mRNA differential expression in normal tissues according to GTEx for YIPF1 Gene

This gene is overexpressed in Whole Blood (x6.8).

Protein differential expression in normal tissues from HIPED for YIPF1 Gene

This gene is overexpressed in Pancreas (47.4) and Placenta (21.6).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for YIPF1 Gene



Protein tissue co-expression partners for YIPF1 Gene

NURSA nuclear receptor signaling pathways regulating expression of YIPF1 Gene:

YIPF1

SOURCE GeneReport for Unigene cluster for YIPF1 Gene:

Hs.11923

Evidence on tissue expression from TISSUES for YIPF1 Gene

  • Nervous system(4.5)
  • Lung(4.2)
  • Pancreas(4.2)
  • Muscle(2.9)
genes like me logo Genes that share expression patterns with YIPF1: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for YIPF1 Gene

Orthologs for YIPF1 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for YIPF1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia YIPF1 35 34
  • 99.78 (n)
OneToOne
dog
(Canis familiaris)
Mammalia YIPF1 35 34
  • 92.13 (n)
OneToOne
cow
(Bos Taurus)
Mammalia YIPF1 34
  • 90.96 (n)
rat
(Rattus norvegicus)
Mammalia Yipf1 34
  • 84.2 (n)
mouse
(Mus musculus)
Mammalia Yipf1 16 35 34
  • 83.77 (n)
oppossum
(Monodelphis domestica)
Mammalia YIPF1 35
  • 81 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia YIPF1 35
  • 80 (a)
OneToOne
chicken
(Gallus gallus)
Aves YIPF1 35 34
  • 75.61 (n)
OneToOne
lizard
(Anolis carolinensis)
Reptilia YIPF1 35
  • 78 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia yipf1 34
  • 67.01 (n)
zebrafish
(Danio rerio)
Actinopterygii yipf1 35 34
  • 61.99 (n)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta CG4645 34 35
  • 50.55 (n)
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP006951 34
  • 48.19 (n)
worm
(Caenorhabditis elegans)
Secernentea Y25C1A.7 34 35
  • 51.47 (n)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes YIP5 37
thale cress
(Arabidopsis thaliana)
eudicotyledons AT5G27490 34
  • 47.59 (n)
rice
(Oryza sativa)
Liliopsida Os01g0610500 34
  • 47.4 (n)
bread mold
(Neurospora crassa)
Ascomycetes NCU05276 34
  • 44.74 (n)
fission yeast
(Schizosaccharomyces pombe)
Schizosaccharomycetes SPAC227.06 34
  • 44.25 (n)
sea squirt
(Ciona savignyi)
Ascidiacea -- 35
  • 41 (a)
OneToMany
Species where no ortholog for YIPF1 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for YIPF1 Gene

ENSEMBL:
Gene Tree for YIPF1 (if available)
TreeFam:
Gene Tree for YIPF1 (if available)

Paralogs for YIPF1 Gene

Paralogs for YIPF1 Gene

(1) SIMAP similar genes for YIPF1 Gene using alignment to 4 proteins:

genes like me logo Genes that share paralogs with YIPF1: view

Variants for YIPF1 Gene

Sequence variations from dbSNP and Humsavar for YIPF1 Gene

SNP ID Clin Chr 01 pos Sequence Context AA Info Type
rs1000125411 -- 53,862,952(+) TGCAG(C/T)GCACA intron-variant
rs1000197616 -- 53,864,422(+) TAAAG(C/T)GCATG intron-variant
rs1000198653 -- 53,879,023(+) AGTAT(A/G)TAGAA intron-variant
rs1000219304 -- 53,883,011(+) TGAGC(C/T)GTCAT intron-variant, nc-transcript-variant
rs1000246903 -- 53,863,271(+) CAACA(A/G)GGAAG intron-variant

Structural Variations from Database of Genomic Variants (DGV) for YIPF1 Gene

Variant ID Type Subtype PubMed ID
esv27981 CNV loss 19812545
esv3586078 CNV loss 21293372
nsv1011262 CNV gain 25217958
nsv1113119 CNV deletion 24896259

Variation tolerance for YIPF1 Gene

Residual Variation Intolerance Score: 62.3% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 7.91; 83.80% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for YIPF1 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
YIPF1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for YIPF1 Gene

Disorders for YIPF1 Gene

MalaCards: The human disease database

(1) MalaCards diseases for YIPF1 Gene - From: DISEASES and GeneCards

Disorder Aliases PubMed IDs
de quervain disease
  • radial styloid tenosynovitis
- elite association - COSMIC cancer census association via MalaCards
Search YIPF1 in MalaCards View complete list of genes associated with diseases

Relevant External Links for YIPF1

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
YIPF1
genes like me logo Genes that share disorders with YIPF1: view

No data available for UniProtKB/Swiss-Prot and Genatlas for YIPF1 Gene

Publications for YIPF1 Gene

  1. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4 64
  2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4 64
  3. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg R.L. … Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002) 2 3 64
  4. A proteome-scale map of the human interactome network. (PMID: 25416956) Rolland T. … Vidal M. (Cell 2014) 3 64
  5. Insights into RNA biology from an atlas of mammalian mRNA-binding proteins. (PMID: 22658674) Castello A. … Hentze M.W. (Cell 2012) 3 64

Products for YIPF1 Gene

Sources for YIPF1 Gene

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