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Aliases for YIF1B Gene

Aliases for YIF1B Gene

  • Yip1 Interacting Factor Homolog B, Membrane Trafficking Protein 2 3 5
  • YIP1-Interacting Factor Homolog B 3 4
  • Yip1 Interacting Factor Homolog B (S. Cerevisiae) 2
  • Protein YIF1B 3
  • FinGER8 3

External Ids for YIF1B Gene

Previous GeneCards Identifiers for YIF1B Gene

  • GC19M043488
  • GC19M038794
  • GC19M035242

Summaries for YIF1B Gene

GeneCards Summary for YIF1B Gene

YIF1B (Yip1 Interacting Factor Homolog B, Membrane Trafficking Protein) is a Protein Coding gene. An important paralog of this gene is YIF1A.

No data available for Entrez Gene Summary , CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for YIF1B Gene

Genomics for YIF1B Gene

Regulatory Elements for YIF1B Gene

Enhancers for YIF1B Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH19G038269 1.5 Ensembl ENCODE dbSUPER 11.4 +46.6 46569 1.7 ARNT SIN3A FEZF1 ZNF2 YY1 FOS ZNF592 SMARCA4 ZSCAN16 GLIS1 C19orf33 CATSPERG ZNF607 ZNF793 LOC100631378 KCNK6 DPF1 YIF1B ENSG00000269688 GGN
GH19G038276 1.4 Ensembl ENCODE dbSUPER 11.9 +39.4 39379 2.6 PKNOX1 KLF17 SIN3A RAD21 ZNF121 GATA2 SCRT2 ZNF143 FOS CREM C19orf33 ZNF793 ZNF781 ENSG00000267152 ZNF607 PPP1R14A SPINT2 YIF1B KCNK6 CATSPERG
GH19G038262 1.4 ENCODE dbSUPER 11.5 +51.4 51408 6.7 HDGF FOXA2 PKNOX1 MLX AGO1 ZFP64 SIN3A ARID4B DMAP1 ZNF2 ZNF573 ZNF607 ZNF793 ZNF569 C19orf33 ZNF570 CATSPERG LOC100631378 PPP1R14A LOC284412
GH19G038233 0.9 ENCODE 16.3 +83.3 83278 0.2 HDGF PKNOX1 RB1 ARID4B KLF17 SIN3A ZNF2 ZNF48 RAD21 ZNF121 YIF1B PPP1R14A KCNK6 CATSPERG RASGRP4 RYR1 SPRED3 GGN FAM98C GC19M038235
GH19G038373 1.2 ENCODE 11.1 -58.1 -58120 3.2 CREB3L1 AGO1 FEZF1 DMAP1 YY1 SLC30A9 ZNF143 SP3 NFYC TBX21 CATSPERG ZNF793 KCNK6 ZNF781 ENSG00000267152 ZNF607 FBXO17 FAM98C YIF1B PPP1R14A
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around YIF1B on UCSC Golden Path with GeneCards custom track

Promoters for YIF1B Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000109270 1373 1401 PKNOX1 CREB3L1 ARNT ARID4B SIN3A DMAP1 ZNF2 YY1 CBX5 ZNF143

Transcription factor binding sites by QIAGEN in the YIF1B gene promoter:

Genomic Location for YIF1B Gene

Chromosome:
19
Start:
38,303,560 bp from pter
End:
38,317,273 bp from pter
Size:
13,714 bases
Orientation:
Minus strand

Genomic View for YIF1B Gene

Genes around YIF1B on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
YIF1B Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for YIF1B Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for YIF1B Gene

Proteins for YIF1B Gene

  • Protein details for YIF1B Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q5BJH7-YIF1B_HUMAN
    Recommended name:
    Protein YIF1B
    Protein Accession:
    Q5BJH7
    Secondary Accessions:
    • H7BXS8
    • Q5JPC2
    • Q8WY70
    • Q96C02
    • Q96IC4

    Protein attributes for YIF1B Gene

    Size:
    314 amino acids
    Molecular mass:
    34435 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for YIF1B Gene

neXtProt entry for YIF1B Gene

Post-translational modifications for YIF1B Gene

  • Ubiquitination at posLast=123123
  • Modification sites at PhosphoSitePlus

No data available for DME Specific Peptides for YIF1B Gene

Domains & Families for YIF1B Gene

Gene Families for YIF1B Gene

Protein Domains for YIF1B Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for YIF1B Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q5BJH7

UniProtKB/Swiss-Prot:

YIF1B_HUMAN :
  • Belongs to the YIF1 family.
Family:
  • Belongs to the YIF1 family.
genes like me logo Genes that share domains with YIF1B: view

Function for YIF1B Gene

genes like me logo Genes that share phenotypes with YIF1B: view

Animal Model Products

  • Taconic Biosciences Mouse Models for YIF1B

CRISPR Products

miRNA for YIF1B Gene

miRTarBase miRNAs that target YIF1B

Flow Cytometry Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for YIF1B Gene

Localization for YIF1B Gene

Subcellular locations from UniProtKB/Swiss-Prot for YIF1B Gene

Membrane; Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for YIF1B gene
Compartment Confidence
golgi apparatus 4
plasma membrane 3
endoplasmic reticulum 3
mitochondrion 1

Gene Ontology (GO) - Cellular Components for YIF1B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005789 endoplasmic reticulum membrane IBA --
GO:0005793 endoplasmic reticulum-Golgi intermediate compartment IBA --
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IEA --
GO:0030134 ER to Golgi transport vesicle IBA --
genes like me logo Genes that share ontologies with YIF1B: view

Pathways & Interactions for YIF1B Gene

SuperPathways for YIF1B Gene

No Data Available

Gene Ontology (GO) - Biological Process for YIF1B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006888 ER to Golgi vesicle-mediated transport IBA --
genes like me logo Genes that share ontologies with YIF1B: view

No data available for Pathways by source and SIGNOR curated interactions for YIF1B Gene

Transcripts for YIF1B Gene

Unigene Clusters for YIF1B Gene

Yip1 interacting factor homolog B (S. cerevisiae):
Representative Sequences:

CRISPR Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for YIF1B Gene

ExUns: 1a · 1b · 1c ^ 2a · 2b · 2c ^ 3a · 3b ^ 4a · 4b ^ 5 ^ 6a · 6b ^ 7a · 7b ^ 8 ^ 9a · 9b · 9c ^ 10 ^ 11a · 11b
SP1: - - - - - - - - -
SP2: - - - - - - - -
SP3: - - - - - - - -
SP4: - - - -
SP5: - - -
SP6: - - -
SP7: - -
SP8: - -
SP9: - -
SP10: -
SP11: - - -
SP12: -

Relevant External Links for YIF1B Gene

GeneLoc Exon Structure for
YIF1B
ECgene alternative splicing isoforms for
YIF1B

Expression for YIF1B Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for YIF1B Gene

Protein differential expression in normal tissues from HIPED for YIF1B Gene

This gene is overexpressed in Bone (15.7), Breast (14.6), and Platelet (7.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for YIF1B Gene



Protein tissue co-expression partners for YIF1B Gene

NURSA nuclear receptor signaling pathways regulating expression of YIF1B Gene:

YIF1B

SOURCE GeneReport for Unigene cluster for YIF1B Gene:

Hs.280741

Evidence on tissue expression from TISSUES for YIF1B Gene

  • Intestine(4.3)
  • Lymph node(4.3)
  • Lung(4.2)
  • Nervous system(2.2)
genes like me logo Genes that share expression patterns with YIF1B: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for YIF1B Gene

Orthologs for YIF1B Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for YIF1B Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia YIF1B 34 35
  • 99.04 (n)
dog
(Canis familiaris)
Mammalia YIF1B 34 35
  • 91.88 (n)
cow
(Bos Taurus)
Mammalia YIF1B 34 35
  • 91.05 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia YIF1B 35
  • 88 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Yif1b 34 16 35
  • 87.67 (n)
rat
(Rattus norvegicus)
Mammalia Yif1b 34
  • 86.89 (n)
oppossum
(Monodelphis domestica)
Mammalia YIF1B 35
  • 81 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia YIF1B 35
  • 74 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia yif1b 34
  • 71.08 (n)
MGC76182 34
African clawed frog
(Xenopus laevis)
Amphibia Xl.12281 34
zebrafish
(Danio rerio)
Actinopterygii yif1b 34 35
  • 69.86 (n)
fruit fly
(Drosophila melanogaster)
Insecta CG5484 34 35
  • 56.54 (n)
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP002175 34
  • 53.61 (n)
worm
(Caenorhabditis elegans)
Secernentea yif-1 35
  • 23 (a)
OneToMany
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes YIF1 35 37
  • 20 (a)
OneToMany
thale cress
(Arabidopsis thaliana)
eudicotyledons AT3G59500 34
  • 46.41 (n)
rice
(Oryza sativa)
Liliopsida Os04g0165400 34
  • 46.78 (n)
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.15300 34
Species where no ortholog for YIF1B was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for YIF1B Gene

ENSEMBL:
Gene Tree for YIF1B (if available)
TreeFam:
Gene Tree for YIF1B (if available)

Paralogs for YIF1B Gene

Paralogs for YIF1B Gene

(1) SIMAP similar genes for YIF1B Gene using alignment to 6 proteins:

genes like me logo Genes that share paralogs with YIF1B: view

Variants for YIF1B Gene

Sequence variations from dbSNP and Humsavar for YIF1B Gene

SNP ID Clin Chr 19 pos Sequence Context AA Info Type
rs1000039999 -- 38,311,827(+) GGCGC(A/G)GTGGC intron-variant
rs1000094952 -- 38,312,057(+) AAGAT(A/C)GCGCC intron-variant
rs1000276430 -- 38,310,597(+) AGGAA(-/G)GGGGG intron-variant
rs1000387631 -- 38,317,897(+) ATTTA(A/C)TTAAT intron-variant, upstream-variant-2KB
rs1000814974 -- 38,316,043(+) CCCCC(C/T)GACCC upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for YIF1B Gene

Variant ID Type Subtype PubMed ID
esv3644307 CNV loss 21293372
nsv833822 CNV loss 17160897

Variation tolerance for YIF1B Gene

Residual Variation Intolerance Score: 21.5% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 5.60; 72.44% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for YIF1B Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
YIF1B

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for YIF1B Gene

Disorders for YIF1B Gene

Relevant External Links for YIF1B

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
YIF1B

No disorders were found for YIF1B Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for YIF1B Gene

Publications for YIF1B Gene

  1. The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment. (PMID: 12975309) Clark H.F. … Gray A.M. (Genome Res. 2003) 2 3 4 64
  2. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 3 64
  3. A human interactome in three quantitative dimensions organized by stoichiometries and abundances. (PMID: 26496610) Hein M.Y. … Mann M. (Cell 2015) 3 64
  4. A Dynamic Protein Interaction Landscape of the Human Centrosome-Cilium Interface. (PMID: 26638075) Gupta G.D. … Pelletier L. (Cell 2015) 3 64
  5. Defining human ERAD networks through an integrative mapping strategy. (PMID: 22119785) Christianson J.C. … Kopito R.R. (Nat. Cell Biol. 2012) 3 64

Products for YIF1B Gene

Sources for YIF1B Gene

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