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YIF1B Gene

protein-coding   GIFtS: 46

GC19M043488
Yip1 interacting factor homolog B (S. cerevisiae)
Symbol approved by the HUGO Gene Nomenclature Committee (HGNC) database
Services    
(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc , and/or 7Ensembl, 8miRBase)
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Aliases
FLJ23477 2
FLJ50074 2
FinGER8 1, 2
MGC39135 2
Descriptions
YIP1-interacting factor homolog B 3
Yip1 interacting factor homolog B 2
Yip1 interacting factor homolog B (S. cerevisiae) 2
External Ids
HGNC: 305111
Entrez Gene: 905222
UniProtKB: Q5BJH73
Ensembl: ENSG000001676457
Search outside databases for aliases for YIF1B gene

(According to Entrez Gene, Wikipedia's Gene Wiki,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

  --
(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 36),
and/or miRBase,
Genomic Views according to UCSC and Ensembl, Transcription factor binding sites according to SABiosciences)
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Genomic View:
UCSC Golden Path with GeneCards custom track

 Transcription factor binding sites upstream to the YIF1B gene  

Entrez Gene cytogenetic band: 19q13.2   Ensembl cytogenetic band:  19q13.2   HGNC cytogenetic band: 19q13.2

YIF1B Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)

GeneLoc gene densities for chromosome 19         GeneLoc Exon Structure

GeneLoc location for GC19M043488:     (about GC identifiers)

Start:
43,487,584 bp from pter
End:
43,498,446 bp from pter
Size:
10,863 bases
Orientation:
minus strand
RefSeq DNA sequence:
NC_000019.8  NT_011109.15  
(According to 1UniProtKB, and/or Ensembl, Phosphorylation sites according to 2Phosphosite, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Enzo Life Sciences, Abnova, OriGene and/or, Abcam,
Biochemical Assays by Invitrogen, Millipore, R&D Systems, Cell Signaling Technology, and/or Enzo Life Sciences, Ontologies according to Gene Ontology Consortium 01 Apr 2009 and Entrez Gene, Antibodies by Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Cell Signaling Technology, Abcam, Abnova, and/or Novus Biologicals)
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UniProtKB/Swiss-Prot: YIF1B_HUMAN, Q5BJH7 (See protein sequence)
Recommended Name: Protein YIF1B  
Size: 314 amino acids; 34435 Da
Subcellular location: Membrane; Multi-pass membrane protein (Potential)
Secondary accessions: Q5JPC2 Q8WY70 Q96C02 Q96IC4
Alternative splicing: 5 isoforms:  Q5BJH7-1   Q5BJH7-2   Q5BJH7-3   Q5BJH7-4   Q5BJH7-5   

Post-translational modifications:

  • View phosphorylation sites using PhosphoSite2


  • REFSEQ proteins (7 alternative transcripts): 
    NP_001034760.1  NP_001034761.1  NP_001034762.1  NP_001138933.1  NP_001138934.1  NP_001138935.1  NP_291035.1  


    ENSEMBL proteins: 
    ENSP00000337411 ENSP00000375971 ENSP00000384808 ENSP00000329559 ENSP00000343435 


    Human Recombinant Proteins 
    Browse Drug Discovery Central at Invitrogen for human recombinant proteins
    Browse Purified and Recombinant Proteins at Millipore
    Browse Human Recombinant Proteins at Sigma-Aldrich  
    Browse R&D Systems for human recombinant proteins
    Browse recombinant and purified proteins available from Enzo Life Sciences
    Recombinant Proteins from Abcam (YIF1B)
    Human Recombinant Proteins from Abnova (YIF1B)
                    Browse Origene for full length recombinant human proteins expressed in human HEK293 cells 

    2 Gene Ontology (GO) cellular component terms (links to tree view):

    GO IDQualified GO termEvidencePubMed IDs
    GO:0016020 membrane IEA--
    GO:0016021 integral to membrane IEA--
    About this table

    Antibodies for YIF1B: 
    Browse Antibodies Central at Invitrogen
    Browse Millipore's Extensive Line of Mono- and Polyclonal Antibodies
    Browse Antibodies at Sigma-Aldrich
    Browse R&D Systems for Antibodies
    Antibodies from Abcam (YIF1B), each with their AbpromiseSM
    Browse Abnova for Monoclonal and Polyclonal Antibodies
    Search Novus for antibodies for YIF1B

    Assays for YIF1B: 
    Browse Invitrogen for biochemical assays
    Browse Kits and Assays available from Millipore
    Browse R&D Systems for biochemical assays
    Browse biochemical assays available from Enzo Life Sciences

    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section

    1 InterPro domain/family:
     IPR005578 Hrf1


       GeneDecks  YIF1B for the domains selected above  
    About GeneDecksing

    Graphical View of Domain Structure for InterPro Entry Q5BJH7

    ProtoNet protein and cluster: Q5BJH7

    UniProtKB/Swiss-Prot: YIF1B_HUMAN, Q5BJH7
    Similarity: Belongs to the YIF1 family

    (According to MGI Jun 06 2009, UniProtKB, IUBMB,and/or Genatlas,
    shRNA from OriGene, Sigma-Aldrich, RNAi from Sigma-Aldrich,
    RNAi Products, Clones, and Q-PCR Products from Invitrogen, Millipore, OriGene, and/or Abnova, siRNAs from Applied Biosystems, SYBR primers from OriGene, Cell-based Assays from Millipore, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
    About This Section

    Inhib.
    RNA:
    Invitrogen RNAi Products for gene knock-down (YIF1B)
    Browse for Gene Knock-down Tools from Millipore
    Browse Abnova for Chimera RNAi Products
                   OriGene 29mer shRNA kit in GFP-retroviral vectors (see all 9): NM_001039671

                  Applied Biosystems Silencer® siRNAs for YIF1B

                  Sigma-Aldrich siRNA for YIF1B  
                         Browse shRNA at Sigma-Aldrich  
                         Explore Sigma-Aldrich super-pooled esiRNAs  

    Clones:Invitrogen Clones for YIF1B
    Browse Clones for the Expression of Recombinant Proteins Available from Millipore
                   OriGene GFP tagged cDNA clones in CMV expression vector (see all 7): NM_001039671
                                     Myc/DDK tagged cDNA clones in CMV expression vector (see all 7): NM_001039671
                                     untagged cDNA clones in CMV expression vector (see all 9): BC014974 

    Primers: Browse Quantitative PCR Central at Invitrogen for Q-PCR LUX™ Primers
                  OriGene genome-wide validated SYBR primer pairs: NM_001039672

    (Pathways according to Invitrogen (maps by GeneGo), Millipore, Cell Signaling Technology, Sigma-Aldrich, KEGG and/or UniProtKB,
    Sets of similar genes according to GeneDecks, Proteins Network according to SABiosciences, Interactions according to 1UniProtKB, 2MINT, and/or 3STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
    About This Section


      --
    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, Sigma-Aldrich, Tocris Bioscience, and/or Novoseek and Drugs according to Enzo Life Sciences and/or PharmGKB)
    About This Section

    Browse drugs & compounds from Enzo Life Sciences
    Browse Small Molecules at Sigma-Aldrich

    Browse Tocris compounds for YIF1B

    (GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 219 Homo sapiens; Jun 2 2009) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView,
    non coding RNAs according to RNAdb,
    ESTs according to GeneTide,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from Invitrogen, Millipore, and/or Abnova,
    siRNAs from Applied Biosystems, Sigma-Aldrich,
    shRNA from Sigma-Aldrich, OriGene,
    Tagged/untagged cDNA clones from OriGene,
    Expression Assays from Applied Biosystems)
    About This Section

    Inhib.
    RNA:
    Invitrogen RNAi Products for gene knock-down (YIF1B)
    Browse for Gene Knock-down Tools from Millipore
    Browse Abnova for Chimera RNAi Products
                   OriGene 29mer shRNA kit in GFP-retroviral vectors (see all 9): NM_001039671

                  Sigma-Aldrich siRNA for YIF1B  
                         Browse shRNA at Sigma-Aldrich  
                         Explore Sigma-Aldrich super-pooled esiRNAs  

    Applied Biosystems Silencer® siRNAs: 

    NM_001039671  NM_001039672  NM_001039673  NM_033557  

    REFSEQ mRNAs for YIF1B gene (7 alternative transcripts): 

    NM_001039671.2   NM_001039672.2   NM_001039673.2   NM_001145461.1   NM_001145462.1   NM_001145463.1   NM_033557.3   

    Applied Biosystems TaqMan ® Gene Expression Assays: 

    NM_001039671  NM_001039672  NM_001039673  NM_033557  

                   OriGene GFP tagged cDNA clones in CMV expression vector (see all 7): NM_001039671
                                     Myc/DDK tagged cDNA clones in CMV expression vector (see all 7): NM_001039671
                                     untagged cDNA clones in CMV expression vector (see all 9): BC014974 

    Additional cDNA sequence: 

    AK027130.1 AL833382.1 AY358965.1 BC007644.1 BC014974.1 BC025257.1 BC091477.1 CR594602.1 
    CR597352.1 CR597805.1 CR598537.1 CR601973.1 CR616030.1 

    24 DOTS entries:

    DT.310298  DT.100762081  DT.121483044  DT.100755106  DT.97846838  DT.100755105  DT.100755104  DT.100772849 
    DT.121483028  DT.92431507  DT.121482967  DT.92431508  DT.92424415  DT.100692309  DT.100713714  DT.102831790 
    DT.40284236  DT.86854239  DT.92431504  DT.95190672  DT.121482970  DT.75118830  DT.95153722  DT.99937702 

    24/218 AceView cDNA sequences (see all 218 ):

    BM717386 CR616030 BF339777 AW002546 BM923272 BU615679 BM703847 BI963081 
    CR597805 NM_033557 AI538475 BQ680270 AI380916 AL833382 BX354499 AI085552 
    AF258578 BM708247 BM665108 BU620538 CB961267 AW271667 C02248 BG116654 

    highest scoring ESTs for YIF1B:

    AI074877 AI079540 AJ705254 AL833382 BC007644 BC014974 BE745405 BE746235 BE780379 BE782991 

    Unigene Cluster for YIF1B:

    Yip1 interacting factor homolog B (S. cerevisiae)
    Hs.280741  [show with all ESTs]
    Unigene Representative Sequence: NM_033557


    GeneLoc Exon Structure

    5/12 Alternative Splicing Database (ASD) splice patterns (SP) for YIF1B (see all 12 )

    ExUns: 1a · 1b · 1c ^ 2a · 2b · 2c ^ 3a · 3b ^ 4a · 4b ^ 5 ^ 6a · 6b ^ 7a · 7b ^ 8 ^ 9a · 9b · 9c ^ 10 ^ 11a · 11b
    SP1:              -     -     -     -     -     -     -                 -                                               -               
    SP2:                    -     -     -     -     -     -                 -                                               -               
    SP3:              -     -     -     -     -     -     -                 -                                                               
    SP4:                                      -     -     -                 -                                                               
    SP5:                                            -     -                 -                                                               

    About this scheme

    ECgene alternative splicing isoforms for YIF1B

    5 Ensembl transcripts including schematic representations:
    ENST00000337679  ENST00000392124  ENST00000404021  ENST00000329420  ENST00000339413  
    (Experimental results according to 1GeneNote and GNF BioGPS,
    probe sets-to-genes annotations according to 2GeneAnnot , 3GeneTide , Sets of similar genes according to GeneDecks, Electronic Northern calculations according to data from UniGene (Build 219 Homo sapiens), SAGE tags according to CGAP, plus additional links to SOURCE, and/or GNF BioGPS, and/or EXPOLDB, and/or UniProtKB,
    Expression Assays from Applied Biosystems )
    About This Section

    YIF1B expression in normal and diseased human tissues

     Applied Biosystems TaqMan ® Gene Expression Assays for YIF1B

    1 / 2 / 3

    11 probe-sets matching YIF1B gene


    Affymetrix
    probe-set
    Array  GeneAnnot data GeneNote data GeneTide data
    # genes Sensitivity Specificity Correlation Length Gb_Accession Consensus Uniqueness Score Rank

    65141_at2, 3 U95-C 1 1.00 1.00 0.33 1.12 AI079540 0.80 1.00 0.91 1

    55690_at2 U95-C 1 1.00 1.00 0.26 0.59 -- -- -- -- --

    44343_s_at2, 3 U95-B 1 1.00 1.00 0.56 1.16 AI074877 0.80 1.00 0.91 1

    72114_at*2, 3 U95-E 1 -- -- 0.78 1.15 AI538475 0.60 1.00 0.82 1

    226437_at2, 3 U133-B 1 1.00 1.00 -- -- AI079540 0.80 1.00 0.91 1

    231211_s_at2 U133-B 1 1.00 1.00 -- -- -- -- -- -- --

    220207_at2 U133-A 1 1.00 1.00 -- -- -- -- -- -- --

    226437_at2 U133Plus2 1 1.00 1.00 -- -- -- -- -- -- --

    1554553_s_at2 U133Plus2 1 1.00 1.00 -- -- -- -- -- -- --

    231211_s_at2 U133Plus2 1 1.00 1.00 -- -- -- -- -- -- --

    220207_at2 U133Plus2 1 1.00 1.00 -- -- -- -- -- -- --
    About this table
    Data from (Publications) and GNF BioGPS
        About these images
    About these images

    CGAP SAGE TAG: --

    SOURCE GeneReport for Unigene cluster: Hs.280741
    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD and/or 5MGI Jun 06 2009, with possible further links to Flybase and/or WormBase, Gene Trees according to Ensembl)
    About This Section


    Orthologs for YIF1B gene from 5/14 species (see all 14 )
    Organism Gene Locus Description Human
    Similarity
    NCBI accessions
    dog
    (Canis familiaris)
    YIF1B1   -- Yip1 interacting factor homolog B (S. cerevisiae) 91.8(n)
    96.12(a)
    484532  XM_541646.2  XP_541646.2 
    chimpanzee
    (Pan troglodytes)
    YIF1B1   -- Yip1 interacting factor homolog B (S. cerevisiae) 99.04(n)
    99.36(a)
    456004  XM_512634.2  XP_512634.1 
    cow
    (Bos taurus)
    YIF1B1   -- Yip1 interacting factor homolog B (S. cerevisiae) 91.26(n)
    93.2(a)
    617320  XM_869552.2  XP_874645.2 
    rat
    (Rattus norvegicus)
    Yif1b1   -- Yip1 interacting factor homolog B (S. cerevisiae) 86.82(n)
    90.35(a)
    292768  NM_198734.2  NP_942029.2 
    mouse
    (Mus musculus)
    Yif1b1, 5 75
    Yip1 interacting factor homolog B (S. cerevisiae)1, 5 87.35(n)1
    89.68(a)1
    772541  NM_029887.21  NP_084163.11 
     AK0204445  AK1355295  (see all 11)
    About this table        Species with no ortholog for YIF1B

    ENSEMBL Gene Tree for YIF1B
    (Paralogs according to 1HomoloGene
    and 2Ensembl, Pseudogenes according to 3Pseudogene.org)
    About This Section

    Paralogs for YIF1B gene
    YIF1A2  

    (According to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, and UniProtKB, Linkage Disequilibrium by HapMap, Genotyping Reagents from Applied Biosystems)
    About This Section


    10/56 NCBI SNPs in YIF1B are shown (see all 56 )
    (Click for Applied Biosystems TaqMan ® Genotyping Assay)  (see all 27)
    ABGenomic DataTranscription DataAllele Frequencies
    SNP IDValidChr 19 posSequenceRecsAA
    Chg
    TypeMoreRecsAllele
    freq
    PopTotal
    sample
    More
    ------------
    rs38437541,2
    A,C,F,H43499024(+) TCTCTG/ACAGAC 3 -- ng318Minor allele frequency- A:0.34NA EA MN EU WA 850
    rs116725311,2
    C,F43494253(+) AGGACT/GTGCTG 4 -- int1 ng312Minor allele frequency- G:0.16NA 182
    rs22784361,2
    F,H43498542(+) CCCCCC/ATTCAC 3 -- ng31 trp34Minor allele frequency- A:0.01EU EA WA 412
    rs115569921,2
    C,F43492016(-) GGGCAT/CCTGGT 4 S/P mis15Minor allele frequency- C:0.39NA EU EA WA 490
    --
    rs72575371,2
    A43498612(+) CATGCA/TGTAAA 3 -- ng310--------
    rs31783271,2
    A,C,F,H43489926(-) TGCGTA/GGCCAT 4 V/V syn110Minor allele frequency- G:0.35EU EA WA NA 814
    rs39009811,2
    C,F,H43492005(-) GGCCTG/AAGTTA 4 L/L syn1 ese314Minor allele frequency- A:0.18MN EU EA WA NA 1448
    rs43124171,2
    A,C,F,H43489029(+) TATCCA/GAGGCT 4 -- int18Minor allele frequency- G:0.40EU EA WA 836
    rs38595501,2
    C,F,H43489786(+) CTCCAC/GGGCTC 4 -- int112Minor allele frequency- N:0.00EU EA WA NA 1046
    --
    rs72601371,2
    A,C43495536(+) aagcaA/Gttctc 3 -- int10--------
    About this table

    HapMap Linkage Disequilibrium images for YIF1B (up to first 250kb)

    (in which this Gene is Involved, According to OMIM, UniProtKB, PharmGKB, Genatlas, GeneTests, Blood group antigen gene mutations by BGMUT, HGMD, GAD, HuGE Navigator, BCGD, and/or TGDB.)
    About This Section

      --

    (Possibly Related Articles in Doctor's Guide)
    About This Section

      --

    (in PubMed. Associations of this gene to articles via 1Novoseek, 2HGNC, 3Entrez Gene, 4UniProtKB/Swiss-Prot, 5UniProtKB/TrEMBL, 6GAD, and/or 7PharmGKB)
    About This Section

    8 PubMed articles for YIF1B gene:
    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section

     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)
    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, and/or H-InvDB)
    About This Section

    Entrez Gene: 90522 HGNC: 30511 AceView: LOC90522 Ensembl:ENSG00000167645 euGenes: HUgn90522
    ECgene: YIF1B H-InvDB: YIF1B
    (According to HUGE)
    About This Section

      --
    (According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section

      --
    (Available from WIS Yeda, Salk, Tufts)
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      --
    (Reagents available from Applied Biosystems, Antibodies and assays by Cell Signaling Technology, Abcam, Novus Biologicals,
    Sigma-Aldrich, R&D Systems, Millipore, Abnova, and/or Invitrogen, Clones available from OriGene,and/or Invitrogen, Drugs and/or compounds by Sigma-Aldrich,
    Enzo Life Sciences, and/or Tocris Bioscience)
    About This Section



    Products for YIF1B:
     TaqMan ® Gene Expression Assays
     TaqMan ® Genotyping Assays
      Free SNP selection tool



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     Predesigned and custom siRNAs for YIF1B Browse antibodies at Sigma-Aldrich
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