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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

YIF1B Gene

protein-coding   GIFtS: 46
GCID: GC19M038794

Yip1 Interacting Factor Homolog B (S. Cerevisiae)

  Search for YIF1B
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Yip1 Interacting Factor Homolog B (S. Cerevisiae)1 2
YIP1-Interacting Factor Homolog B2 3
FinGER82
Protein YIF1B2

External Ids:    HGNC: 305111   Entrez Gene: 905222   Ensembl: ENSG000001676457   UniProtKB: Q5BJH73   

Export aliases for YIF1B gene to outside databases

Previous GC identifers: GC19M043488 GC19M035242


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

GeneCards Summary for YIF1B Gene: 
YIF1B (Yip1 interacting factor homolog B (S. cerevisiae)) is a protein-coding gene. An important paralog of this gene is YIF1A.


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000019.9  NT_011109.16  NC_018930.2  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the YIF1B gene promoter:
         AhR   Arnt   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidYIF1B promoter sequence
   Search SABiosciences Chromatin IP Primers for YIF1B

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat YIF1B


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 19q13.2   Ensembl cytogenetic band:  19q13.2   HGNC cytogenetic band: 19q13.2

YIF1B Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
YIF1B gene location

GeneLoc information about chromosome 19         GeneLoc Exon Structure

GeneLoc location for GC19M038794:  view genomic region     (about GC identifiers)

Start:
38,794,200 bp from pter      End:
38,807,913 bp from pter
Size:
13,714 bases      Orientation:
minus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: YIF1B_HUMAN, Q5BJH7 (See protein sequence)
Recommended Name: Protein YIF1B  
Size: 314 amino acids; 34435 Da
Subcellular location: Membrane; Multi-pass membrane protein (Potential)
Secondary accessions: H7BXS8 Q5JPC2 Q8WY70 Q96C02 Q96IC4
Alternative splicing: 6 isoforms:  Q5BJH7-1   Q5BJH7-2   Q5BJH7-3   Q5BJH7-4   Q5BJH7-5   Q5BJH7-6   (Gene prediction based on EST data)

Explore the universe of human proteins at neXtProt for YIF1B: NX_Q5BJH7

Explore proteomics data for YIF1B at MOPED 

Post-translational modifications:

  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_Q5BJH7

  • YIF1B Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    YIF1B Protein Expression
    REFSEQ proteins (7 alternative transcripts): 
    NP_001034760.1  NP_001034761.1  NP_001034762.1  NP_001138933.1  NP_001138934.1  NP_001138935.1  NP_291035.1  

    ENSEMBL proteins: 
     ENSP00000466428   ENSP00000337411   ENSP00000375971   ENSP00000343435   ENSP00000467489  
     ENSP00000329559   ENSP00000465230   ENSP00000465446   ENSP00000468358   ENSP00000468463  
     ENSP00000465277  

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    Cloud-Clone Corp. Proteins for YIF1B 

    Gene Ontology (GO): 2 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0016020membrane ----
    GO:0016021integral to membrane IEA--

    YIF1B for ontologies           About GeneDecksing



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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    1 InterPro protein domain:
     IPR005578 Hrf1

    Graphical View of Domain Structure for InterPro Entry Q5BJH7

    ProtoNet protein and cluster: Q5BJH7

    UniProtKB/Swiss-Prot: YIF1B_HUMAN, Q5BJH7
    Similarity: Belongs to the YIF1 family


    YIF1B for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Animal Models:
       inGenious Targeting Laboratory - Custom generated mouse model solutions for YIF1B 
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       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for YIF1B 
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    miRNA
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    3 QIAGEN miScript miRNA Assays for microRNAs that regulate YIF1B:
    hsa-miR-3065-3p hsa-miR-143 hsa-miR-143*
    SwitchGear 3'UTR luciferase reporter plasmidYIF1B 3' UTR sequence
    Inhib. RNA
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    In Situ Assay
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for YIF1B


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section




    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for YIF1B

    STRING Interaction Network Preview (showing 5 interactants - click image to see more details)

    5/10 Interacting proteins for YIF1B (Q5BJH73 ENSP000003434354) via UniProtKB, MINT, STRING, and/or I2D (see all 10)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    YIPF5Q969M33, ENSP000002744964I2D: score=2 STRING: ENSP00000274496
    CAPN15O758083I2D: score=2 
    RGS16O154923I2D: score=2 
    UBE2E2Q96LR53I2D: score=2 
    DESI2Q9BSY93I2D: score=1 
    About this table

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for YIF1B

    Search CenterWatch for drugs/clinical trials and news about YIF1B

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for YIF1B gene (9 alternative transcripts): 
    NM_001013617.1  NM_001031731.1  NM_001039671.2  NM_001039672.2  NM_001039673.2  NM_001145461.1  NM_001145462.1  NM_001145463.1  
    NM_033557.3  

    Unigene Cluster for YIF1B:

    Yip1 interacting factor homolog B (S. cerevisiae)
    Hs.280741  [show with all ESTs]
    Unigene Representative Sequence: NM_033557
    16 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000592694 ENST00000337679(uc002oia.2 uc002oib.3) ENST00000392124(uc002ohw.2)
    ENST00000586319 ENST00000339413(uc002ohy.2 uc002ohz.2) ENST00000592246
    ENST00000329420(uc002ohx.2 uc010xtx.1 uc010xty.1) ENST00000591784
    ENST00000589151 ENST00000591755 ENST00000589644 ENST00000588002 ENST00000585563
    ENST00000589247 ENST00000587361 ENST00000587039
    miRNA
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    3 QIAGEN miScript miRNA Assays for microRNAs that regulate YIF1B:
    hsa-miR-3065-3p hsa-miR-143 hsa-miR-143*
    SwitchGear 3'UTR luciferase reporter plasmidYIF1B 3' UTR sequence
    Inhib. RNA
    Products:
         
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    GenScript: all cDNA clones in your preferred vector (see all 7): YIF1B (NM_001039672)
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      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat YIF1B
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat YIF1B

    Additional mRNA sequence: 

    AF258578.3 AK027130.1 AL833382.1 AY358965.1 BC007644.1 BC014974.1 BC025257.1 BC091477.1 

    24/28 DOTS entries (see all 28):

    DT.310298  DT.100762081  DT.121483044  DT.97846838  DT.100755105  DT.100755106  DT.92424415  DT.100772849 
    DT.100755104  DT.121483028  DT.92431507  DT.121482967  DT.92431508  DT.100692309  DT.100713714  DT.75118830 
    DT.102831790  DT.86854239  DT.87016176  DT.92431504  DT.95190672  DT.121482970  DT.121483079  DT.75101399 

    24/218 AceView cDNA sequences (see all 218):

    BM703847 CR601973 BC014974 BM717386 BM923272 BU620538 AF258578 AW002546 
    AI380916 CR597352 CR598537 BU615679 BM695737 BX092259 AI184105 AY358965 
    CB961267 BX354499 C02248 AW271667 AI085552 CR597805 BM708247 NM_033557 

    GeneLoc Exon Structure

    5/12 Alternative Splicing Database (ASD) splice patterns (SP) for YIF1B (see all 12)    About this scheme

    ExUns: 1a · 1b · 1c ^ 2a · 2b · 2c ^ 3a · 3b ^ 4a · 4b ^ 5 ^ 6a · 6b ^ 7a · 7b ^ 8 ^ 9a · 9b · 9c ^ 10 ^ 11a · 11b
    SP1:              -     -     -     -     -     -     -                 -                                               -               
    SP2:                    -     -     -     -     -     -                 -                                               -               
    SP3:              -     -     -     -     -     -     -                 -                                                               
    SP4:                                      -     -     -                 -                                                               
    SP5:                                            -     -                 -                                                               


    ECgene alternative splicing isoforms for YIF1B

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    YIF1B expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: --
    YIF1B Expression
    About this image


    See YIF1B Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for YIF1B

    SOURCE GeneReport for Unigene cluster: Hs.280741
        SABiosciences Custom PCR Arrays for YIF1B
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    In Situ
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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of eukaryotes.

    Orthologs for YIF1B gene from 9/18 species (see all 18)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Yif1b1 , 5 Yip1 interacting factor homolog B (S. cerevisiae)1, 5 87.46(n)1
    90.35(a)1
      7 (16.94 cM)5
    772541  NM_029887.31  NP_084163.21 
     292383295 
    lizard
    (Anolis carolinensis)
    Reptilia YIF1B6
    Yip1 interacting factor homolog B (S. cerevisiae)
    73(a)
    1 ↔ 1
    LGf(1868343-1873155)
    African clawed frog
    (Xenopus laevis)
    Amphibia Xl.122812 Xenopus laevis transcribed sequence with weak similarity more 74.87(n)    48041647 
    zebrafish
    (Danio rerio)
    Actinopterygii yif1b1 Yip1 interacting factor homolog B (S. cerevisiae) 69.75(n)
    72.95(a)
      492462  NM_001007334.1  NP_001007335.2 
    fruit fly
    (Drosophila melanogaster)
    Insecta CG54841 CG5484 56.38(n)
    48.58(a)
      43217  NM_170284.1  NP_733163.1 
    worm
    (Caenorhabditis elegans)
    Secernentea yif-16
    Protein YIF-1, isoform b
    24(a)
    1 → many
    V(10049862-10054915)
    baker's yeast
    (Saccharomyces cerevisiae)
    Saccharomycetes YIF1(YNL263C)4 Integral membrane protein required for the fusion of more   --   14(147840-146896) 855458  NP_014136.1 
    thale cress
    (Arabidopsis thaliana)
    eudicotyledons AT3G595001 YIF1 integral membrane domain-containing protein 45.8(n)
    34.87(a)
      825119  NM_115812.3  NP_191509.2 
    rice
    (Oryza sativa)
    Liliopsida Os04g01654001 hypothetical protein 47.97(n)
    33.33(a)
      4335045  NM_001058667.1  NP_001052132.1 


    ENSEMBL Gene Tree for YIF1B (if available)
    TreeFam Gene Tree for YIF1B (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for YIF1B gene
    YIF1A2  
    1 SIMAP similar gene for YIF1B using alignment to 5 protein entries:     YIF1B_HUMAN (see all proteins):
    YIF1A

    YIF1B for paralogs           About GeneDecksing


    1 Pseudogenes.org Pseudogene for YIF1B
    PGOHUM00000259329


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/287 SNPs in YIF1B are shown (see all 287)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 19 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1826982981,2
    --35250244(+) ATCACC/TAGGTC 1 -- us2k10--------
    rs1487136851,2
    --35250331(+) GGTGCA/GTGCCT 1 -- us2k10--------
    rs1859624931,2
    --35250392(+) ACCGGA/GGAGGT 1 -- us2k10--------
    rs2022413921,2
    --38796159(+) GGGAAA/GGAGAG 7 -- int10--------
    rs72519141,2
    C,H--38796164(+) AGAGAG/AAGAGG 7 -- int1 trp36Minor allele frequency- A:0.00NS EA NA 414
    rs1167437511,2
    C,F--38796178(+) CAAGGG/AATTTA 7 -- int11Minor allele frequency- A:0.02WA 118
    rs770271921,2
    C,F--38796286(+) GCCTCA/GGGTTT 7 -- int11Minor allele frequency- G:0.03NA 120
    rs746197031,2
    C--38796383(+) GTTCCA/GTACTC 7 -- int15Minor allele frequency- G:0.16CSA WA NA EA 361
    rs1920234061,2
    --38796413(+) GGAGCC/GGGTGA 7 -- int10--------
    rs1123118401,2
    C--38796572(+) GGTGCG/ATTGGC 7 -- int14Minor allele frequency- A:0.11CSA WA NA EA 359

    HapMap Linkage Disequilibrium report for YIF1B (38794200 - 38807913 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 2 variations for YIF1B:    About this table     
    Variant IDTypeSubtypePubMed ID
    nsv911658CNV Loss21882294
    nsv833822CNV Loss17160897

    SABiosciences Cancer Mutation PCR Assays
    SeqTarget long-range PCR primers for resequencing YIF1B
    DNA2.0 Custom Variant and Variant Library Synthesis for YIF1B

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
      --

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for YIF1B gene, integrated from 9 sources (see all 18):
    (articles sorted by number of sources associating them with YIF1B)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment. (PubMed id 12975309)1, 2, 3 Clark H.F.... Gray A.M. (2003)
    2. A census of human soluble protein complexes. (PubMed id 22939629)1 Havugimana P.C....Emili A. (2012)
    3. Systematic and quantitative assessment of the ubiquiti n-modified proteome. (PubMed id 21906983)1 Kim W....Gygi S.P. (2011)
    4. Initial characterization of the human central proteome. (PubMed id 21269460)2 Burkard T.R.... Colinge J. (2011)
    5. Mass spectrometric analysis of lysine ubiquitylation r eveals promiscuity at site level. (PubMed id 21139048)1 Danielsen J.M....Nielsen M.L. (2011)
    6. Global identification of modular cullin-RING ligase su bstrates. (PubMed id 21963094)1 Emanuele M.J....Elledge S.J. (2011)
    7. Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis. (PubMed id 20068231)2 Olsen J.V....Mann M. (2010)
    8. Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions. (PubMed id 19690332)2 Mayya V.... Han D.K. (2009)
    9. A quantitative atlas of mitotic phosphorylation. (PubMed id 18669648)2 Dephoure N.... Gygi S.P. (2008)
    10. Quantitative analysis of global ubiquitination in HeLa cells by mass spectrometry. (PubMed id 18781797)1 Meierhofer D.... Kaiser P. (2008)

    (in PubMed, OMIM, and NCBI Bookshelf)
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    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 90522 HGNC: 30511 AceView: LOC90522 Ensembl:ENSG00000167645 euGenes: HUgn90522
    ECgene: YIF1B H-InvDB: YIF1B

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for YIF1B Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for YIF1B gene:
    Search GeneIP for patents involving YIF1B

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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