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Aliases for YIF1B Gene

Aliases for YIF1B Gene

  • Yip1 Interacting Factor Homolog B, Membrane Trafficking Protein 2 3
  • Yip1 Interacting Factor Homolog B (S. Cerevisiae) 2 5
  • YIP1-Interacting Factor Homolog B 3 4
  • Yip1 Interacting Factor Homolog B 3
  • FinGER8 3

External Ids for YIF1B Gene

Previous GeneCards Identifiers for YIF1B Gene

  • GC19M043488
  • GC19M038794
  • GC19M035242

Summaries for YIF1B Gene

GeneCards Summary for YIF1B Gene

YIF1B (Yip1 Interacting Factor Homolog B, Membrane Trafficking Protein) is a Protein Coding gene. An important paralog of this gene is YIF1A.

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for YIF1B Gene

Genomics for YIF1B Gene

Regulatory Elements for YIF1B Gene

Enhancers for YIF1B Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around YIF1B on UCSC Golden Path with GeneCards custom track

Promoters for YIF1B Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around YIF1B on UCSC Golden Path with GeneCards custom track

Transcription factor binding sites by QIAGEN in the YIF1B gene promoter:

Genomic Location for YIF1B Gene

Chromosome:
19
Start:
38,303,560 bp from pter
End:
38,317,273 bp from pter
Size:
13,714 bases
Orientation:
Minus strand

Genomic View for YIF1B Gene

Genes around YIF1B on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
YIF1B Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for YIF1B Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for YIF1B Gene

Proteins for YIF1B Gene

  • Protein details for YIF1B Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q5BJH7-YIF1B_HUMAN
    Recommended name:
    Protein YIF1B
    Protein Accession:
    Q5BJH7
    Secondary Accessions:
    • H7BXS8
    • Q5JPC2
    • Q8WY70
    • Q96C02
    • Q96IC4

    Protein attributes for YIF1B Gene

    Size:
    314 amino acids
    Molecular mass:
    34435 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for YIF1B Gene

neXtProt entry for YIF1B Gene

Proteomics data for YIF1B Gene at MOPED

Post-translational modifications for YIF1B Gene

  • Ubiquitination at Lys 123
  • Modification sites at PhosphoSitePlus

No data available for DME Specific Peptides for YIF1B Gene

Domains & Families for YIF1B Gene

Gene Families for YIF1B Gene

Protein Domains for YIF1B Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for YIF1B Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q5BJH7

UniProtKB/Swiss-Prot:

YIF1B_HUMAN :
  • Belongs to the YIF1 family.
Family:
  • Belongs to the YIF1 family.
genes like me logo Genes that share domains with YIF1B: view

Function for YIF1B Gene

genes like me logo Genes that share phenotypes with YIF1B: view

Animal Model Products

  • Taconic Biosciences Mouse Models for YIF1B

miRNA for YIF1B Gene

miRTarBase miRNAs that target YIF1B

Flow Cytometry Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for YIF1B Gene

Localization for YIF1B Gene

Subcellular locations from UniProtKB/Swiss-Prot for YIF1B Gene

Membrane; Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for YIF1B Gene COMPARTMENTS Subcellular localization image for YIF1B gene
Compartment Confidence
plasma membrane 3
golgi apparatus 1
mitochondrion 1

No data available for Gene Ontology (GO) - Cellular Components for YIF1B Gene

Pathways & Interactions for YIF1B Gene

SuperPathways for YIF1B Gene

No Data Available

Interacting Proteins for YIF1B Gene

Gene Ontology (GO) - Biological Process for YIF1B Gene

None

No data available for Pathways by source and SIGNOR curated interactions for YIF1B Gene

Drugs & Compounds for YIF1B Gene

No Compound Related Data Available

Transcripts for YIF1B Gene

Unigene Clusters for YIF1B Gene

Yip1 interacting factor homolog B (S. cerevisiae):
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for YIF1B Gene

ExUns: 1a · 1b · 1c ^ 2a · 2b · 2c ^ 3a · 3b ^ 4a · 4b ^ 5 ^ 6a · 6b ^ 7a · 7b ^ 8 ^ 9a · 9b · 9c ^ 10 ^ 11a · 11b
SP1: - - - - - - - - -
SP2: - - - - - - - -
SP3: - - - - - - - -
SP4: - - - -
SP5: - - -
SP6: - - -
SP7: - -
SP8: - -
SP9: - -
SP10: -
SP11: - - -
SP12: -

Relevant External Links for YIF1B Gene

GeneLoc Exon Structure for
YIF1B
ECgene alternative splicing isoforms for
YIF1B

Expression for YIF1B Gene

mRNA expression in normal human tissues for YIF1B Gene

Protein differential expression in normal tissues from HIPED for YIF1B Gene

This gene is overexpressed in Bone (15.7), Breast (14.6), and Platelet (7.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for YIF1B Gene



SOURCE GeneReport for Unigene cluster for YIF1B Gene Hs.280741

genes like me logo Genes that share expression patterns with YIF1B: view

Protein tissue co-expression partners for YIF1B Gene

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for YIF1B Gene

Orthologs for YIF1B Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for YIF1B Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia YIF1B 35
  • 91.05 (n)
  • 93.2 (a)
YIF1B 36
  • 93 (a)
OneToOne
dog
(Canis familiaris)
Mammalia YIF1B 35
  • 91.88 (n)
  • 96.15 (a)
YIF1B 36
  • 83 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Yif1b 35
  • 87.67 (n)
  • 91 (a)
Yif1b 16
Yif1b 36
  • 90 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia YIF1B 35
  • 99.04 (n)
  • 99.36 (a)
YIF1B 36
  • 99 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Yif1b 35
  • 86.89 (n)
  • 91 (a)
oppossum
(Monodelphis domestica)
Mammalia YIF1B 36
  • 81 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia YIF1B 36
  • 88 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia YIF1B 36
  • 74 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia MGC76182 35
yif1b 35
  • 71.08 (n)
  • 75.26 (a)
African clawed frog
(Xenopus laevis)
Amphibia Xl.12281 35
zebrafish
(Danio rerio)
Actinopterygii yif1b 35
  • 69.86 (n)
  • 72.95 (a)
yif1b 36
  • 69 (a)
OneToOne
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP002175 35
  • 53.61 (n)
  • 44.78 (a)
fruit fly
(Drosophila melanogaster)
Insecta CG5484 35
  • 56.54 (n)
  • 47.7 (a)
CG5484 36
  • 33 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea yif-1 36
  • 23 (a)
OneToMany
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes YIF1 36
  • 20 (a)
OneToMany
YIF1 38
thale cress
(Arabidopsis thaliana)
eudicotyledons AT3G59500 35
  • 46.41 (n)
  • 35.44 (a)
rice
(Oryza sativa)
Liliopsida Os04g0165400 35
  • 46.78 (n)
  • 32.51 (a)
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.15300 35
Species with no ortholog for YIF1B:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for YIF1B Gene

ENSEMBL:
Gene Tree for YIF1B (if available)
TreeFam:
Gene Tree for YIF1B (if available)

Paralogs for YIF1B Gene

Paralogs for YIF1B Gene

(1) SIMAP similar genes for YIF1B Gene using alignment to 6 proteins:

Pseudogenes.org Pseudogenes for YIF1B Gene

genes like me logo Genes that share paralogs with YIF1B: view

Variants for YIF1B Gene

Sequence variations from dbSNP and Humsavar for YIF1B Gene

SNP ID Clin Chr 19 pos Sequence Context AA Info Type
rs11556992 - 38,309,536(-) GGGCA(A/C/T)CTGGT reference, missense
rs7257537 -- 38,316,132(+) CATGC(A/T)GTAAA upstream-variant-2KB
rs7260137 -- 38,313,056(+) aagca(A/G)ttctc intron-variant
rs8104432 -- 38,309,076(+) GAGAC(A/G)GGCAG intron-variant
rs62638004 -- 38,310,155(+) ACCCA(C/T)CCACC intron-variant

Structural Variations from Database of Genomic Variants (DGV) for YIF1B Gene

Variant ID Type Subtype PubMed ID
nsv833822 CNV Loss 17160897
nsv911658 CNV Loss 21882294

Variation tolerance for YIF1B Gene

Residual Variation Intolerance Score: 21.5% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 5.60; 72.44% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for YIF1B Gene

HapMap Linkage Disequilibrium report
YIF1B

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for YIF1B Gene

Disorders for YIF1B Gene

Relevant External Links for YIF1B

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
YIF1B

No disorders were found for YIF1B Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for YIF1B Gene

Publications for YIF1B Gene

  1. The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment. (PMID: 12975309) Clark H.F. … Gray A.M. (Genome Res. 2003) 2 3 4 67
  2. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 3
  3. A human interactome in three quantitative dimensions organized by stoichiometries and abundances. (PMID: 26496610) Hein M.Y. … Mann M. (Cell 2015) 3
  4. A Dynamic Protein Interaction Landscape of the Human Centrosome-Cilium Interface. (PMID: 26638075) Gupta G.D. … Pelletier L. (Cell 2015) 3
  5. Defining human ERAD networks through an integrative mapping strategy. (PMID: 22119785) Christianson J.C. … Kopito R.R. (Nat. Cell Biol. 2012) 3

Products for YIF1B Gene

Sources for YIF1B Gene

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