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Aliases for YIF1A Gene

Aliases for YIF1A Gene

  • Yip1 Interacting Factor Homolog A, Membrane Trafficking Protein 2 3 5
  • YIP1-Interacting Factor Homolog A 3 4
  • 54TMp 3 4
  • YIF1 3 4
  • 54TM 3 4
  • Yip1 Interacting Factor Homolog (S. Cerevisiae) 2
  • Putative Transmembrane Protein 54TMp 3
  • Putative Rab5-Interacting Protein 3
  • Yip1p-Interacting Factor 3
  • Protein YIF1A 3
  • FinGER7 3
  • HYIF1P 4
  • YIF1P 3

External Ids for YIF1A Gene

Previous HGNC Symbols for YIF1A Gene

  • YIF1

Previous GeneCards Identifiers for YIF1A Gene

  • GC11M065809
  • GC11M066052
  • GC11M062434

Summaries for YIF1A Gene

GeneCards Summary for YIF1A Gene

YIF1A (Yip1 Interacting Factor Homolog A, Membrane Trafficking Protein) is a Protein Coding gene. Among its related pathways are Unfolded Protein Response (UPR) and Metabolism of proteins. An important paralog of this gene is YIF1B.

UniProtKB/Swiss-Prot for YIF1A Gene

  • Possible role in transport between endoplasmic reticulum and Golgi.

Gene Wiki entry for YIF1A Gene

Additional gene information for YIF1A Gene

No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for YIF1A Gene

Genomics for YIF1A Gene

Regulatory Elements for YIF1A Gene

Enhancers for YIF1A Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH11H066324 1.9 FANTOM5 Ensembl ENCODE dbSUPER 12.9 -37.7 -37686 5 HDGF MLX ARID4B SIN3A DMAP1 ZNF2 YY1 SLC30A9 ZNF207 ZNF143 RIN1 ACTN3 YIF1A TMEM151A LOC100505504 SLC29A2 ENSG00000255320 PACS1 ENSG00000201733 CTSF
GH11H066311 1.8 FANTOM5 ENCODE dbSUPER 11.4 -26.2 -26164 8 HDGF PKNOX1 MLX ARNT ZFP64 ARID4B SIN3A YBX1 DMAP1 ZNF2 RIN1 ENSG00000255320 EIF1AD PCNX3 RBM14 KDM2A RBM4 ENSG00000258297 EHBP1L1 SART1
GH11H065470 2.7 VISTA FANTOM5 Ensembl ENCODE dbSUPER 5.8 +799.1 799087 39 MLX ZFP64 FEZF1 DMAP1 YBX1 YY1 SLC30A9 ZNF143 SP3 MCM3 SF1 ZFPL1 POLA2 LOC105369352 SART1 PCNX3 EIF1AD KAT5 SF3B2 MUS81
GH11H066386 1.1 Ensembl ENCODE 10.4 -97.3 -97267 0 HDAC1 PKNOX1 RB1 RAD21 ZNF121 ZNF143 CREM THAP11 SMARCA5 ZNF654 LOC100505504 NPAS4 ENSG00000201733 PELI3 MRPL11 DPP3 LOC101928069 YIF1A TMEM151A KLC2
GH11H066322 0.8 ENCODE dbSUPER 11.4 -33.3 -33295 0 ELF3 CTCF REST RAD21 ZNF644 THAP11 BRMS1 YIF1A TMEM151A ENSG00000255320 PACS1 CD248 ENSG00000254756
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around YIF1A on UCSC Golden Path with GeneCards custom track

Promoters for YIF1A Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000040949 70 1401 HDGF PKNOX1 MLX ARID4B SIN3A DMAP1 YY1 SLC30A9 ZNF207 ZNF143

Genomic Location for YIF1A Gene

Chromosome:
11
Start:
66,284,580 bp from pter
End:
66,289,170 bp from pter
Size:
4,591 bases
Orientation:
Minus strand

Genomic View for YIF1A Gene

Genes around YIF1A on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
YIF1A Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for YIF1A Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for YIF1A Gene

Proteins for YIF1A Gene

  • Protein details for YIF1A Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    O95070-YIF1A_HUMAN
    Recommended name:
    Protein YIF1A
    Protein Accession:
    O95070
    Secondary Accessions:
    • A6NM00
    • Q96G83
    • Q9BVD0

    Protein attributes for YIF1A Gene

    Size:
    293 amino acids
    Molecular mass:
    32011 Da
    Quaternary structure:
    • Interacts with YIPF5.

neXtProt entry for YIF1A Gene

Post-translational modifications for YIF1A Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for YIF1A Gene

Domains & Families for YIF1A Gene

Gene Families for YIF1A Gene

HGNC:
Human Protein Atlas (HPA):
  • Predicted intracellular proteins
  • Predicted membrane proteins

Protein Domains for YIF1A Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for YIF1A Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

O95070

UniProtKB/Swiss-Prot:

YIF1A_HUMAN :
  • Belongs to the YIF1 family.
Family:
  • Belongs to the YIF1 family.
genes like me logo Genes that share domains with YIF1A: view

Function for YIF1A Gene

Molecular function for YIF1A Gene

UniProtKB/Swiss-Prot Function:
Possible role in transport between endoplasmic reticulum and Golgi.

Phenotypes From GWAS Catalog for YIF1A Gene

Gene Ontology (GO) - Molecular Function for YIF1A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 22645275
genes like me logo Genes that share ontologies with YIF1A: view
genes like me logo Genes that share phenotypes with YIF1A: view

Animal Model Products

CRISPR Products

miRNA for YIF1A Gene

miRTarBase miRNAs that target YIF1A

Inhibitory RNA Products

Clone Products

  • Applied Biological Materials Clones for YIF1A
  • Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for YIF1A Gene

Localization for YIF1A Gene

Subcellular locations from UniProtKB/Swiss-Prot for YIF1A Gene

Endoplasmic reticulum membrane; Multi-pass membrane protein. Golgi apparatus membrane; Multi-pass membrane protein. Note=Cycles between the endoplasmic reticulum and the endoplasmic reticulum-Golgi intermediate compartment. {ECO:0000269 PubMed:15308636}.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for YIF1A gene
Compartment Confidence
golgi apparatus 5
endoplasmic reticulum 4
plasma membrane 3
cytoskeleton 2
mitochondrion 1
cytosol 1
endosome 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Golgi apparatus (3)
  • Microtubule organizing center (3)
  • Vesicles (3)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for YIF1A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005783 endoplasmic reticulum IEA --
GO:0005789 endoplasmic reticulum membrane TAS,IBA --
GO:0005793 endoplasmic reticulum-Golgi intermediate compartment IDA 15308636
GO:0005794 Golgi apparatus IEA --
GO:0016020 membrane IEA --
genes like me logo Genes that share ontologies with YIF1A: view

Pathways & Interactions for YIF1A Gene

genes like me logo Genes that share pathways with YIF1A: view

Gene Ontology (GO) - Biological Process for YIF1A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006810 transport IEA --
GO:0006888 ER to Golgi vesicle-mediated transport IBA --
GO:0015031 protein transport IEA --
GO:0016192 vesicle-mediated transport IEA --
GO:0036498 IRE1-mediated unfolded protein response TAS --
genes like me logo Genes that share ontologies with YIF1A: view

No data available for SIGNOR curated interactions for YIF1A Gene

Drugs & Compounds for YIF1A Gene

No Compound Related Data Available

Transcripts for YIF1A Gene

Unigene Clusters for YIF1A Gene

Yip1 interacting factor homolog A (S. cerevisiae):
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

  • Applied Biological Materials Clones for YIF1A
  • Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more

Alternative Splicing Database (ASD) splice patterns (SP) for YIF1A Gene

ExUns: 1a · 1b · 1c ^ 2a · 2b ^ 3 ^ 4a · 4b ^ 5 ^ 6 ^ 7a · 7b · 7c · 7d ^ 8a · 8b ^ 9a · 9b · 9c
SP1: - - - - -
SP2: - - - - - - -
SP3: - - - -
SP4: - - - - -
SP5: - -
SP6:
SP7:

Relevant External Links for YIF1A Gene

GeneLoc Exon Structure for
YIF1A
ECgene alternative splicing isoforms for
YIF1A

Expression for YIF1A Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for YIF1A Gene

Protein differential expression in normal tissues from HIPED for YIF1A Gene

This gene is overexpressed in Nasal epithelium (55.9).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for YIF1A Gene



Protein tissue co-expression partners for YIF1A Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of YIF1A Gene:

YIF1A

SOURCE GeneReport for Unigene cluster for YIF1A Gene:

Hs.446445

Evidence on tissue expression from TISSUES for YIF1A Gene

  • Nervous system(4.6)
  • Blood(4.1)
  • Pancreas(2.6)
  • Muscle(2)
genes like me logo Genes that share expression patterns with YIF1A: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for YIF1A Gene

Orthologs for YIF1A Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for YIF1A Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia YIF1A 33 34
  • 99.89 (n)
cow
(Bos Taurus)
Mammalia YIF1A 33 34
  • 93.97 (n)
dog
(Canis familiaris)
Mammalia YIF1A 33 34
  • 92.95 (n)
mouse
(Mus musculus)
Mammalia Yif1a 33 16 34
  • 88.17 (n)
rat
(Rattus norvegicus)
Mammalia Yif1a 33
  • 87.94 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia YIF1A 34
  • 56 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia YIF1A 34
  • 63 (a)
OneToOne
zebrafish
(Danio rerio)
Actinopterygii yif1a 33 34
  • 64.79 (n)
wufa11c09 33
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.887 33
fruit fly
(Drosophila melanogaster)
Insecta CG5484 34
  • 28 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea yif-1 33 34
  • 45.19 (n)
A. gosspyii yeast
(Ashbya gossypii)
Saccharomycetes AGOS_AFR658W 33
  • 47.19 (n)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes YIF1 34 33
  • 44.17 (n)
OneToMany
K. lactis yeast
(Kluyveromyces lactis)
Saccharomycetes KLLA0C02563g 33
  • 37.02 (n)
rice
(Oryza sativa)
Liliopsida Os06g0620600 33
  • 47.13 (n)
bread mold
(Neurospora crassa)
Ascomycetes NCU00624 33
  • 47.15 (n)
fission yeast
(Schizosaccharomyces pombe)
Schizosaccharomycetes hrf1 33
  • 43.36 (n)
Species where no ortholog for YIF1A was found in the sources mined by GeneCards:
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)

Evolution for YIF1A Gene

ENSEMBL:
Gene Tree for YIF1A (if available)
TreeFam:
Gene Tree for YIF1A (if available)

Paralogs for YIF1A Gene

Paralogs for YIF1A Gene

(1) SIMAP similar genes for YIF1A Gene using alignment to 7 proteins:

genes like me logo Genes that share paralogs with YIF1A: view

Variants for YIF1A Gene

Sequence variations from dbSNP and Humsavar for YIF1A Gene

SNP ID Clin Chr 11 pos Sequence Context AA Info Type
rs1000183080 -- 66,286,718(+) GTCAA(C/T)TTTGA intron-variant, utr-variant-3-prime
rs1002223555 -- 66,288,508(+) AGCTG(A/C)GGCAG intron-variant
rs1002884122 -- 66,288,695(+) GGGAC(C/T)TCATC intron-variant
rs1003461071 -- 66,285,182(+) AGACT(C/T)GCAGA intron-variant
rs1004554132 -- 66,285,097(+) CCCAC(A/G)GGGAC intron-variant

Structural Variations from Database of Genomic Variants (DGV) for YIF1A Gene

Variant ID Type Subtype PubMed ID
nsv555223 CNV loss 21841781
nsv825956 CNV gain 20364138

Variation tolerance for YIF1A Gene

Residual Variation Intolerance Score: 80.7% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.76; 47.02% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for YIF1A Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
YIF1A

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for YIF1A Gene

Disorders for YIF1A Gene

Relevant External Links for YIF1A

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
YIF1A

No disorders were found for YIF1A Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for YIF1A Gene

Publications for YIF1A Gene

  1. YIPF5 and YIF1A recycle between the ER and the Golgi apparatus and are involved in the maintenance of the Golgi structure. (PMID: 18718466) Yoshida Y … Nakamura N (Experimental cell research 2008) 2 3 60
  2. Human Yip1A specifies the localization of Yif1 to the Golgi apparatus. (PMID: 15990086) Jin C … Yao X (Biochemical and biophysical research communications 2005) 3 4 60
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 60
  4. Proteomics of endoplasmic reticulum-Golgi intermediate compartment (ERGIC) membranes from brefeldin A-treated HepG2 cells identifies ERGIC-32, a new cycling protein that interacts with human Erv46. (PMID: 15308636) Breuza L … Hauri HP (The Journal of biological chemistry 2004) 3 4 60
  5. A novel Golgi membrane protein is part of a GTPase-binding protein complex involved in vesicle targeting. (PMID: 10970842) Matern H … Gallwitz D (The EMBO journal 2000) 2 3 60

Products for YIF1A Gene

Sources for YIF1A Gene

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