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YIF1A Gene

protein-coding   GIFtS: 49

GC11M065809
Yip1 interacting factor homolog A (S. cerevisiae)
(Previous name: Yip1 interacting factor homolog (S. cerevisiae) )
Symbol approved by the HUGO Gene Nomenclature Committee (HGNC) database
(Previous symbol: YIF1)
Services    
(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc , and/or 7Ensembl, 8miRBase)
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Aliases
54TM 1, 2, 3
54TMp 3
FinGER7 1, 2
HYIF1P 3
OTTHUMP00000128268 2
YIF1 2, 3, 5
YIF1P 1, 2
Descriptions
YIP1-interacting factor homolog A 3
Yip1 interacting factor homolog 2
Yip1 interacting factor homolog (S. cerevisiae) 1
Yip1 interacting factor homolog A (S. cerevisiae) 2
Yip1p-interacting factor 2
putative Rab5-interacting protein 2
putative transmembrane protein 54TMp 2
External Ids
HGNC: 166881
Entrez Gene: 108972
UniProtKB: O950703
Ensembl: ENSG000001748517
Search outside databases for aliases for YIF1A gene

(According to Entrez Gene, Wikipedia's Gene Wiki,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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UniProtKB/Swiss-Prot: YIF1A_HUMAN, O95070
Function: Possible role in transport between endoplasmic reticulum and Golgi

Gene Wiki entry for YIF1A

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 36),
and/or miRBase,
Genomic Views according to UCSC and Ensembl, Transcription factor binding sites according to SABiosciences)
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Genomic View:
UCSC Golden Path with GeneCards custom track

 Transcription factor binding sites upstream to the YIF1A gene  

Entrez Gene cytogenetic band: 11q13   Ensembl cytogenetic band:  11q13.1   HGNC cytogenetic band: 11q13

YIF1A Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)

GeneLoc gene densities for chromosome 11         GeneLoc Exon Structure

GeneLoc location for GC11M065809:     (about GC identifiers)

Start:
65,808,627 bp from pter
End:
65,813,196 bp from pter
Size:
4,570 bases
Orientation:
minus strand
RefSeq DNA sequence:
NC_000011.8  NT_033903.7  
(According to 1UniProtKB, and/or Ensembl, Phosphorylation sites according to 2Phosphosite, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Enzo Life Sciences, Abnova, OriGene and/or, Abcam,
Biochemical Assays by Invitrogen, Millipore, R&D Systems, Cell Signaling Technology, and/or Enzo Life Sciences, Ontologies according to Gene Ontology Consortium 01 Apr 2009 and Entrez Gene, Antibodies by Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Cell Signaling Technology, Abcam, Abnova, and/or Novus Biologicals)
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UniProtKB/Swiss-Prot: YIF1A_HUMAN, O95070 (See protein sequence)
Recommended Name: Protein YIF1A  
Size: 293 amino acids; 32011 Da
Subunit: Interacts with YIPF5
Subcellular location: Endoplasmic reticulum membrane; Multi-pass membrane protein. Golgi apparatus
membrane; Multi-pass membrane protein. Note=Cycles between the endoplasmic reticulum and the
endoplasmic reticulum-Golgi intermediate compartment
Secondary accessions: Q96G83 Q9BVD0

REFSEQ proteins: NP_065203.2  

ENSEMBL proteins: 
ENSP00000366096 ENSP00000366098 ENSP00000352437 ENSP00000366102 


Human Recombinant Proteins 
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Browse recombinant and purified proteins available from Enzo Life Sciences
Browse Abcam for Recombinant Proteins
Human Recombinant Proteins from Abnova (YIF1A)
                Browse Origene for full length recombinant human proteins expressed in human HEK293 cells 

5/7 Gene Ontology (GO) cellular component terms (links to tree view) (see all 7 ):

GO IDQualified GO termEvidencePubMed IDs
GO:0000139 Golgi membrane IEA--
GO:0005783 endoplasmic reticulum IEA--
GO:0005789 endoplasmic reticulum membrane IEA--
GO:0005793 ER-Golgi intermediate compartment IDA15308636
GO:0005794 Golgi apparatus IEA--
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Antibodies for YIF1A: 
Browse Antibodies Central at Invitrogen
Browse Millipore's Extensive Line of Mono- and Polyclonal Antibodies
Sigma-Aldrich Antibodies for YIF1A
Browse R&D Systems for Antibodies
Search for antibodies at Abcam and the World's Antibody Gateway (free search engine of over 150 antibody companies)
Browse Abnova for Monoclonal and Polyclonal Antibodies
Search Novus for antibodies for YIF1A

Assays for YIF1A: 
Browse Invitrogen for biochemical assays
Browse Kits and Assays available from Millipore
Browse R&D Systems for biochemical assays
Browse biochemical assays available from Enzo Life Sciences

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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1 InterPro domain/family:
 IPR005578 Hrf1


   GeneDecks  YIF1A for the domains selected above  
About GeneDecksing

Graphical View of Domain Structure for InterPro Entry O95070

ProtoNet protein and cluster: O95070

UniProtKB/Swiss-Prot: YIF1A_HUMAN, O95070
Similarity: Belongs to the YIF1 family

(According to MGI Jun 06 2009, UniProtKB, IUBMB,and/or Genatlas,
shRNA from OriGene, Sigma-Aldrich, RNAi from Sigma-Aldrich,
RNAi Products, Clones, and Q-PCR Products from Invitrogen, Millipore, OriGene, and/or Abnova, siRNAs from Applied Biosystems, SYBR primers from OriGene, Cell-based Assays from Millipore, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
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Inhib.
RNA:
Invitrogen RNAi Products for gene knock-down (YIF1A)
Browse for Gene Knock-down Tools from Millipore
Browse Abnova for Chimera RNAi Products
              OriGene 29mer shRNA kit in GFP-retroviral vector: NM_020470

              Applied Biosystems Silencer® siRNAs for YIF1A

              Sigma-Aldrich siRNA for YIF1A  
                     Sigma-Aldrich shRNA for YIF1A  
                     Explore Sigma-Aldrich super-pooled esiRNAs  

Clones:Invitrogen Clones for YIF1A
Browse Clones for the Expression of Recombinant Proteins Available from Millipore
              OriGene GFP tagged cDNA clone in CMV expression vector: NM_020470
                                 Myc/DDK tagged cDNA clone in CMV expression vector: NM_020470
                                 untagged cDNA clones in CMV expression vector (see all 2): NM_020470 

Primers: Browse Quantitative PCR Central at Invitrogen for Q-PCR LUX™ Primers
              OriGene genome-wide validated SYBR primer pairs: NM_020470

UniProtKB/Swiss-Prot: YIF1A_HUMAN, O95070
Function: Possible role in transport between endoplasmic reticulum and Golgi

(Pathways according to Invitrogen (maps by GeneGo), Millipore, Cell Signaling Technology, Sigma-Aldrich, KEGG and/or UniProtKB,
Sets of similar genes according to GeneDecks, Proteins Network according to SABiosciences, Interactions according to 1UniProtKB, 2MINT, and/or 3STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
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2 Interacting proteins for YIF1A (ENSP000003660983) via UniProtKB, MINT, and/or STRING
InteractantInteraction Details
GeneCardExternal ID(s)
YIPF5ENSP000003672243STRING (score=.98)
SNX4ENSP000002517753STRING (score=.706)
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2 Gene Ontology (GO) biological process terms (links to tree view):

GO IDQualified GO termEvidencePubMed IDs
GO:0015031 protein transport IEA--
GO:0016192 vesicle-mediated transport IEA--
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(Chemical Compounds according to UniProtKB, Enzo Life Sciences, Sigma-Aldrich, Tocris Bioscience, and/or Novoseek and Drugs according to Enzo Life Sciences and/or PharmGKB)
About This Section

Browse drugs & compounds from Enzo Life Sciences
Browse Small Molecules at Sigma-Aldrich

Browse Tocris compounds for YIF1A

(GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 219 Homo sapiens; Jun 2 2009) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView,
non coding RNAs according to RNAdb,
ESTs according to GeneTide,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from Invitrogen, Millipore, and/or Abnova,
siRNAs from Applied Biosystems, Sigma-Aldrich,
shRNA from Sigma-Aldrich, OriGene,
Tagged/untagged cDNA clones from OriGene,
Expression Assays from Applied Biosystems)
About This Section

Inhib.
RNA:
Invitrogen RNAi Products for gene knock-down (YIF1A)
Browse for Gene Knock-down Tools from Millipore
Browse Abnova for Chimera RNAi Products
              OriGene 29mer shRNA kit in GFP-retroviral vector: NM_020470

              Sigma-Aldrich siRNA for YIF1A  
                     Sigma-Aldrich shRNA for YIF1A  
                     Explore Sigma-Aldrich super-pooled esiRNAs  

Applied Biosystems Silencer® siRNAs: 

NM_020470  

REFSEQ mRNAs for YIF1A gene: 

NM_020470.2   

Applied Biosystems TaqMan ® Gene Expression Assays: 

NM_020470  

              OriGene GFP tagged cDNA clone in CMV expression vector: NM_020470
                                 Myc/DDK tagged cDNA clone in CMV expression vector: NM_020470
                                 untagged cDNA clones in CMV expression vector (see all 2): NM_020470 

Additional cDNA sequence: 

AF004876.1 AK226003.1 AK291124.1 AK308988.1 AK310521.1 AK311173.1 BC001299.1 BC009892.2 
CR456710.1 CR597866.1 CR598403.1 CR606217.1 CR608977.1 CR614462.1 CR615524.1 CR617538.1 
CR623077.1 S83365.1 

15 DOTS entries:

DT.417394  DT.97847847  DT.100792493  DT.100792487  DT.91888989  DT.100792475  DT.100693503  DT.100792486 
DT.100792480  DT.95344941  DT.97847849  DT.100792482  DT.120735076  DT.99943691  DT.120735056 

24/362 AceView cDNA sequences (see all 362 ):

BG742760 BQ935705 CA423814 BQ219362 BI518487 CR597866 CA412249 CA941011 
CF130385 BM995628 BC001299 BC009892 BU077883 AA351007 BQ943730 BU542875 
AL044257 AW246456 BX114584 AA826583 BI257309 BI962834 BQ648541 BE792882 

highest scoring ESTs for YIF1A:

AF004876 AA282191 AA315240 AA341284 AA402390 AL557177 AL574575 AU126446 AW404566 AW407430 

Unigene Cluster for YIF1A:

Yip1 interacting factor homolog A (S. cerevisiae)
Hs.446445  [show with all ESTs]
Unigene Representative Sequence: AK310521


GeneLoc Exon Structure

5/7 Alternative Splicing Database (ASD) splice patterns (SP) for YIF1A (see all 7 )

ExUns: 1a · 1b · 1c ^ 2a · 2b ^ 3 ^ 4a · 4b ^ 5 ^ 6 ^ 7a · 7b · 7c · 7d ^ 8a · 8b ^ 9a · 9b · 9c
SP1:                          -                 -     -           -     -                                             
SP2:                          -                 -     -           -     -     -     -                                 
SP3:                          -                 -     -           -                                                   
SP4:                                            -                 -     -     -     -                                 
SP5:                          -     -                                                                                 

About this scheme

ECgene alternative splicing isoforms for YIF1A

4 Ensembl transcripts including schematic representations:
ENST00000376899  ENST00000376901  ENST00000359461  ENST00000376904  
(Experimental results according to 1GeneNote and GNF BioGPS,
probe sets-to-genes annotations according to 2GeneAnnot , 3GeneTide , Sets of similar genes according to GeneDecks, Electronic Northern calculations according to data from UniGene (Build 219 Homo sapiens), SAGE tags according to CGAP, plus additional links to SOURCE, and/or GNF BioGPS, and/or EXPOLDB, and/or UniProtKB,
Expression Assays from Applied Biosystems )
About This Section

YIF1A expression in normal and diseased human tissues

 Applied Biosystems TaqMan ® Gene Expression Assays for YIF1A

1 / 2 / 3

3 probe-sets matching YIF1A gene


Affymetrix
probe-set
Array  GeneAnnot data GeneNote data GeneTide data
# genes Sensitivity Specificity Correlation Length Gb_Accession Consensus Uniqueness Score Rank

35326_at2, 3 U95-A 1 1.00 1.00 1.00 1.00 AF004876 1.00 1.00 1.00 1

202418_at2, 3 U133-A 1 1.00 1.00 -- -- NM_020470 0.60 1.00 0.82 1

202418_at2 U133Plus2 1 1.00 1.00 -- -- -- -- -- -- --
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Data from (Publications) and GNF BioGPS
    About these images
About these images

CGAP SAGE TAG: GGGGGCCCCG

SOURCE GeneReport for Unigene cluster: Hs.446445

Expression variation in blood from EXPOLDB for YIF1A

(Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD and/or 5MGI Jun 06 2009, with possible further links to Flybase and/or WormBase, Gene Trees according to Ensembl)
About This Section


Orthologs for YIF1A gene from 5/14 species (see all 14 )
Organism Gene Locus Description Human
Similarity
NCBI accessions
dog
(Canis familiaris)
YIF1A1   -- Yip1 interacting factor homolog A (S. cerevisiae) 92.83(n)
95.9(a)
476014  XM_847422.1  XP_852515.1 
chimpanzee
(Pan troglodytes)
YIF1A1   -- Yip1 interacting factor homolog A (S. cerevisiae) 99.77(n)
99.66(a)
746258  XM_001171098.1  XP_001171098.1 
cow
(Bos taurus)
YIF1A1   -- Yip1 interacting factor homolog A (S. cerevisiae) 93.86(n)
96.59(a)
506336  NM_001034269.1  NP_001029441.1 
mouse
(Mus musculus)
Yif1a1, 5 195
Yip1 interacting factor homolog A (S. cerevisiae)1, 5 88.05(n)1
92.15(a)1
680901  NM_026553.31  NP_080829.11 
 AI4136585  AI8397665  (see all 13)
zebrafish
(Danio rerio)
wufa11c092   -- wufa11c09 74.91(n) 334982  BC046046.1 
About this table        Species with no ortholog for YIF1A

ENSEMBL Gene Tree for YIF1A
(Paralogs according to 1HomoloGene
and 2Ensembl, Pseudogenes according to 3Pseudogene.org)
About This Section

Paralogs for YIF1A gene
YIF1B2  

(According to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, and UniProtKB, Linkage Disequilibrium by HapMap, Genotyping Reagents from Applied Biosystems)
About This Section


10/17 NCBI SNPs in YIF1A are shown (see all 17 )
(Click for Applied Biosystems TaqMan ® Genotyping Assay)  (see all 29)
ABGenomic DataTranscription DataAllele Frequencies
SNP IDValidChr 11 posSequenceRecsAA
Chg
TypeMoreRecsAllele
freq
PopTotal
sample
More
------------
--
rs79457231,2
A,C65813033(+) GCCATA/GGCCGC 1 -- ut51 ese30--------
--
rs112274501,2
C65813727(+) TGACTA/CCACCC 1 -- ng310--------
rs115448321,2
C65812261(-) CCAGCC/TCGGGG 1 P/L mis1 ese32Minor allele frequency- T:0.00NA EA 250
--
rs119571,2
C65808934(+) CATGAG/ACGCCG 1 F/L mis1 ese31Minor allele frequency- A:0.00EA 172
rs22825681,2
A,C,F,H65809408(+) CTCCCC/GCTGGC 1 -- int18Minor allele frequency- G:0.24EA EU WA NA 2208
rs31328511,2
A,C,F65812718(+) CCTGGC/AGGCCC 1 -- int11Minor allele frequency- A:0.27EA 172
--
rs5103981,2
C65811399(-) GGACTA/GTATCC 1 -- int1 ese31Minor allele frequency- G:0.00MN 184
--
rs584180711,2
--65813239(+) CCCTCC/TCCTCT 1 -- ng310--------
rs5654681,2
--65811669(+) GGCGTT/AGAGGT 1 Y/N mis1 ese31Minor allele frequency- A:0.00MN 184
--
rs347489661,2
--65813566(+) CCCTG-/CCCTTC 1 -- ng310--------
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HapMap Linkage Disequilibrium images for YIF1A (up to first 250kb)

(in which this Gene is Involved, According to OMIM, UniProtKB, PharmGKB, Genatlas, GeneTests, Blood group antigen gene mutations by BGMUT, HGMD, GAD, HuGE Navigator, BCGD, and/or TGDB.)
About This Section

OMIM: 611484

(Possibly Related Articles in Doctor's Guide)
About This Section

  --

(in PubMed. Associations of this gene to articles via 1Novoseek, 2HGNC, 3Entrez Gene, 4UniProtKB/Swiss-Prot, 5UniProtKB/TrEMBL, 6GAD, and/or 7PharmGKB)
About This Section

10/13 PubMed articles for YIF1A gene (see all 13 ):
(in PubMed, OMIM, and NCBI Bookshelf)
About This Section

 ANDOR
Aliases
Free Text  

  Query String
PubMed
OMIM
NCBI Bookshelf
  (Note: In FireFox, select the above section and copy using Ctrl-C)
(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, and/or H-InvDB)
About This Section

Entrez Gene: 10897 HGNC: 16688 AceView: YIF1 Ensembl:ENSG00000174851 euGenes: HUgn10897
ECgene: YIF1A H-InvDB: YIF1A
(According to HUGE)
About This Section

  --
(According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section

  --
(Available from WIS Yeda, Salk, Tufts)
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  --
(Reagents available from Applied Biosystems, Antibodies and assays by Cell Signaling Technology, Abcam, Novus Biologicals,
Sigma-Aldrich, R&D Systems, Millipore, Abnova, and/or Invitrogen, Clones available from OriGene,and/or Invitrogen, Drugs and/or compounds by Sigma-Aldrich,
Enzo Life Sciences, and/or Tocris Bioscience)
About This Section



Products for YIF1A:
 TaqMan ® Gene Expression Assays
 TaqMan ® Genotyping Assays
  Free SNP selection tool



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