YIF1A Gene
protein-coding GIFtS: 48
GCID: GC11M066052
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Yip1 interacting factor homolog A (S. cerevisiae)(Previous name: Yip1 interacting factor homolog (S. cerevisiae) ) (Previous symbol: YIF1)
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Aliases for YIF1A gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb) About This Section
|
| Aliases |
|---|
| Yip1 Interacting Factor Homolog A (S. Cerevisiae)1 2 | | Yip1 Interacting Factor Homolog (S. Cerevisiae)1 | | YIF11 2 3 5 | | Protein YIF1A2 | | 54TM1 2 3 | | Putative Rab5-Interacting Protein2 | | FinGER71 2 | | Putative Transmembrane Protein 54TMp2 | | YIF1P1 2 | | Yip1p-Interacting Factor2 | | 54TMp2 3 | | HYIF1P3 | | YIP1-Interacting Factor Homolog A2 3 | | |
Export aliases for YIF1A gene to outside databasesPrevious GC identifers: GC11M065809 GC11M062434 |
Summaries for YIF1A gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
| UniProtKB/Swiss-Prot: YIF1A_HUMAN, O95070Function: Possible role in transport between endoplasmic reticulum and Golgi Gene Wiki entry for YIF1A
|
Genomic Views for YIF1A gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics) About This Section
| RefSeq DNA sequence:- NC_000011.9 NC_018922.1 NT_167190.1
Regulatory elements: SABiosciences Regulatory transcription factor binding sites in the YIF1A gene promoter: AhR NRSF form 1 Tal-1beta NRSF form 2 Arnt E47 RORalpha2 c-Ets-1 PPAR-gamma1 Ik-1 Other transcription factors
Search SABiosciences Chromatin IP Primers for YIF1A
Epigenetics:
|  | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat YIF1A |
Genomic Location: Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 11q13 Ensembl cytogenetic band: 11q13.2 HGNC cytogenetic band: 11q13YIF1A Gene in genomic location: bands according to Ensembl, locations according to
(and/or Entrez Gene and/or Ensembl if different)

GeneLoc information about chromosome 11 GeneLoc Exon Structure GeneLoc location for GC11M066052: view genomic region
(about GC identifiers)
Start:
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66,052,051 bp from pter |
End:
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66,056,641 bp from pter |
Size:
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4,591 bases |
Orientation:
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minus strand |
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Proteins for YIF1A gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
| UniProtKB/Swiss-Prot: YIF1A_HUMAN, O95070 (See
protein sequence)Recommended Name: Protein YIF1A Size: 293 amino acids; 32011 Da
Subunit: Interacts with YIPF5
Subcellular location: Endoplasmic reticulum membrane; Multi-pass membrane protein. Golgi apparatus membrane; Multi-passmembrane protein. Note=Cycles between the endoplasmic reticulum and the endoplasmic reticulum-Golgi intermediatecompartment
Secondary accessions: A6NM00 Q96G83 Q9BVD0Explore the universe of human proteins at neXtProt for YIF1A: NX_O95070
Post-translational modifications:
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_O95070 YIF1A Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins: NP_065203.2 ENSEMBL proteins: ENSP00000432185 ENSP00000437042 ENSP00000352437 ENSP00000366098 ENSP00000366102 ENSP00000431665 ENSP00000401953 ENSP00000431935 Reactome Protein details: O95070 Human Recombinant Protein Products:
Gene Ontology (GO): 5/7 cellular component terms (GO ID links to tree view) (see all 7): About this table
YIF1A for ontologies About GeneDecksing
YIF1A Antibody Products: Assay Products for YIF1A: |
Protein
Domains / Families for YIF1A gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
YIF1A for domains About GeneDecksing
1 InterPro domain/family:Graphical View of Domain Structure for InterPro Entry O95070ProtoNet protein and cluster: O95070 UniProtKB/Swiss-Prot: YIF1A_HUMAN, O95070Similarity: Belongs to the YIF1 family |
Function for YIF1A gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
| Function Summary: UniProtKB/Swiss-Prot: YIF1A_HUMAN, O95070Function: Possible role in transport between endoplasmic reticulum and Golgi
Clone Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for YIF1A (see all 3) OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for YIF1A (see all 2) OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling 
| |  | GenScript: all cDNA clones in your preferred vector: YIF1A (NM_020470) | |  | Browse Sino Biological Human cDNA Clones | |  | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for YIF1A | |  | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat YIF1A  |
Gene Ontology (GO): 1 molecular function term (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0005515 | protein binding |
IPI | -- |
YIF1A for ontologies About GeneDecksing
|
Pathways & Interactions for YIF1A gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
| Unified GeneCards pathways  About this table  See pathways by source
| Super-pathway | contained gene-specific pathways |
|---|
| 1 | Activation of Chaperone Genes by XBP1(S) | | | 2 | Expression of YIF1A | | | 3 | Asparagine N-linked glycosylation | |
Pathway sources See GeneCards unified pathways Show all pathways
5
Reactome Pathways for YIF1A
YIF1A for pathways About GeneDecksing
Interactions:
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for YIF1A
STRING Interaction
Network Preview (showing 5 interactants - click image to see 6)
 5/8 Interacting proteins for YIF1A (O950701, 2, 3 ENSP000003660984) via UniProtKB, MINT, STRING, and/or I2D (see all 8)About this table
Gene Ontology (GO): 4 biological process terms (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0006987 | activation of signaling protein activity involved in unfolded protein response |
TAS | -- | | GO:0015031 | protein transport |
IEA | -- | | GO:0016192 | vesicle-mediated transport |
IEA | -- | | GO:0030968 | endoplasmic reticulum unfolded protein response |
TAS | -- |
YIF1A for ontologies About GeneDecksing
|
Drugs & Compounds for YIF1A gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
Browse Tocris compounds for YIF1A Search CenterWatch for drugs/clinical trials and news about YIF1A 
|
Transcripts for YIF1A gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank, RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
) About This Section
| REFSEQ mRNAs for YIF1A gene: NM_020470.2 Unigene Cluster for YIF1A: Yip1 interacting factor homolog A (S. cerevisiae) Hs.446445 [show with all ESTs]Unigene Representative Sequence: AK31052114 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000496746 ENST00000485820 ENST00000526497 ENST00000471387 ENST00000359461 ENST00000376901(uc001ohk.4) ENST00000494836 ENST00000376904 ENST00000484814 ENST00000431556 ENST00000528575 ENST00000376899(uc009yrc.3) ENST00000474986 ENST00000534374
Clone Products: |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for YIF1A (see all 3) OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for YIF1A (see all 2) OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling 
| |  | GenScript: all cDNA clones in your preferred vector: YIF1A (NM_020470) | |  | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for YIF1A | |  | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat YIF1A  |
Additional cDNA sequence: AF004876.1 AK226003.1 AK291124.1 AK308988.1 AK310521.1 AK311173.1 BC001299.1 BC009892.2 CR456710.1 S83365.1 15 DOTS entries: DT.417394 DT.97847847 DT.100792493 DT.100792487 DT.91888989 DT.100792475 DT.100693503 DT.100792486 DT.100792480 DT.95344941 DT.97847849 DT.100792482 DT.120735076 DT.99943691 DT.120735056 24/362 AceView cDNA sequences (see all 362): AA126629 BI257309 BI766139 BG111020 AA826583 CA489035 CR617538 BC009892 CR615524 CF130385 BU541229 BU077883 CR614462 CR597866 AW250560 AA351007 CB992424 BM995628 AW246456 BI962834 BQ086245 CF128449 W45258 BX114584 GeneLoc Exon Structure
5/7 Alternative Splicing Database (ASD) splice patterns (SP) for YIF1A (see all 7) About this scheme
| ExUns: | 1a | · | 1b | · | 1c | ^ | 2a | · | 2b | ^ | 3 | ^ | 4a | · | 4b | ^ | 5 | ^ | 6 | ^ | 7a | · | 7b | · | 7c | · | 7d | ^ | 8a | · | 8b | ^ | 9a | · | 9b | · | 9c | |
| SP1: | |   | |   | |   | |   | - |   | |   | |   | - |   | - |   | |   | - |   | - |   | |   | |   | |   | |   | |   | |   | |   | |
| SP2: | |   | |   | |   | |   | - |   | |   | |   | - |   | - |   | |   | - |   | - |   | - |   | - |   | |   | |   | |   | |   | |   | |
| SP3: | |   | |   | |   | |   | - |   | |   | |   | - |   | - |   | |   | - |   | |   | |   | |   | |   | |   | |   | |   | |   | |
| SP4: | |   | |   | |   | |   | |   | |   | |   | - |   | |   | |   | - |   | - |   | - |   | - |   | |   | |   | |   | |   | |   | |
| SP5: | |   | |   | |   | |   | - |   | - |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   |
ECgene alternative splicing isoforms for YIF1A
|
Expression for YIF1A gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| YIF1A expression in normal human tissues (normalized intensities) See probesets specificity/sensitivity at GeneAnnot About this imageBioGPS CGAP TAG: GGGGGCCCCG
About this image See YIF1A Protein Expression from SPIRE MOPED and PaxDB Genevestigator expression for YIF1A
SOURCE GeneReport for Unigene cluster: Hs.446445 SABiosciences Custom PCR Arrays for YIF1A
Primer Products: |  | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for YIF1A Browse OriGene validated miRNA SYBR primer pairs
| |  | SABiosciences RT2 qPCR Primer Assay in human, mouse, rat YIF1A | |  | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat YIF1A | |  | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat YIF1A |
Orthologs for YIF1A gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of eukaryotes.
Orthologs for YIF1A gene from 7/28 species (see all 28) About this table
ENSEMBL Gene Tree for YIF1A (if available) TreeFam Gene Tree for YIF1A (if available)  |
Paralogs for YIF1A gene(Paralogs according to
1HomoloGene, 2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68) About This Section
| Paralogs for YIF1A gene
- YIF1B2
1 SIMAP similar gene for YIF1A using alignment to 8 protein entries: YIF1A_HUMAN (see all proteins):YIF1B
YIF1A for paralogs About GeneDecksing
|
Genomic Variants for YIF1A gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical significance | Chr 11 pos | Sequence | # | AA Chg | Type | More | # | Allele freq | Pop | Total sample | More |
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HapMap Linkage Disequilibrium report for YIF1A (66052051 - 66056641 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions) Database of Genomic Variants (DGV) variations for YIF1A: --  | SABiosciences Cancer Mutation PCR Assays |
|  | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing YIF1A |
|
Disorders
/ Diseases for YIF1A gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
YIF1A for disorders About MalaCards
YIF1A for disorders About GeneDecksing
OMIM gene information: 611484
OMIM disorders: --
Export disorders for YIF1A gene to outside databases
|
Publications for YIF1A gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for YIF1A gene, integrated from 9 sources (see all 22): (articles sorted by number of sources associating them with YIF1A) | |  | Utopia: connect your pdf to the dynamic world of online information |
- YIPF5 and YIF1A recycle between the ER and the Golgi apparatus and are involved in the maintenance of the Golgi structure. (PubMed id 18718466)1, 3 Yoshida Y....Nakamura N. (2008)
- Human Yip1A specifies the localization of Yif1 to the Golgi apparatus. (PubMed id 15990086)1, 2 Jin C.... Yao X. (2005)
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
- Proteomics of endoplasmic reticulum-Golgi intermediate compartment (ERGIC) membranes from brefeldin A-treated HepG2 cells identifies ERGIC-32, a new cycling protein that interacts with human Erv46. (PubMed id 15308636)1, 2 Breuza L....Hauri H.P. (2004)
- A novel Golgi membrane protein is part of a GTPase-binding protein complex involved in vesicle targeting. (PubMed id 10970842)1, 3 Matern H....Gallwitz D. (2000)
- The GDP/GTP cycle of Rab5 in the regulation of endocytotic membrane traffic. (PubMed id 8824393)1, 3 Vitale G.... Zerial M. (1995)
- Identification of novel ATP13A2 interactors and their role in a-synuclein misfolding and toxicity. (PubMed id 22645275)1 Usenovic M....Krainc D. (2012)
- Large-scale genome-wide association analysis of bipol ar disorder identifies a new susceptibility locus near ODZ4. (PubMed id 21926972)1 Sklar P....Purcell S.M. (2011)
- Initial characterization of the human central proteome. (PubMed id 21269460)2 Burkard T.R.... Colinge J. (2011)
- A directed protein interaction network for investigat ing intracellular signal transduction. (PubMed id 21900206)1 Vinayagam A....Wanker E.E. (2011)
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External Searches for YIF1A gene
(in PubMed,
OMIM, and NCBI Bookshelf) About This Section
|
|
Genome Databases showing YIF1A gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing YIF1A gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing YIF1A gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL, Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot) About This Section
|
| Name | Description |
| PharmGKB entry for YIF1A | Pharmacogenomics, SNPs, Pathways |
|
| | |
About This Section
| Patent Information for YIF1A gene: Search GeneIP for patents involving YIF1A
GeneCards and IP: Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products for YIF1A gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences), In Situ Hybridization Assays from Advanced Cell Diagnostics About This Section
|
 | |
 | |
 |
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| | QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat YIF1A | | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing YIF1A | | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat YIF1A | | QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat YIF1A | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat YIF1A | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat YIF1A |
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 | | YIF1A Proteins, Antibodies, CLIAs, and ELISAs |
| | | |  |  |  | | | Search ThermoFisher Antibodies for YIF1A |
| | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat YIF1A |
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