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Aliases for YIF1A Gene

Aliases for YIF1A Gene

  • Yip1 Interacting Factor Homolog A, Membrane Trafficking Protein 2 3
  • YIP1-Interacting Factor Homolog A 3 4
  • 54TMp 3 4
  • YIF1 3 4
  • 54TM 3 4
  • Yip1 Interacting Factor Homolog A (S. Cerevisiae) 5
  • Yip1 Interacting Factor Homolog (S. Cerevisiae) 2
  • Putative Transmembrane Protein 54TMp 3
  • Yip1 Interacting Factor Homolog A 3
  • Putative Rab5-Interacting Protein 3
  • Yip1p-Interacting Factor 3
  • FinGER7 3
  • HYIF1P 4
  • YIF1P 3

External Ids for YIF1A Gene

Previous HGNC Symbols for YIF1A Gene

  • YIF1

Previous GeneCards Identifiers for YIF1A Gene

  • GC11M065809
  • GC11M066052
  • GC11M062434

Summaries for YIF1A Gene

GeneCards Summary for YIF1A Gene

YIF1A (Yip1 Interacting Factor Homolog A, Membrane Trafficking Protein) is a Protein Coding gene. Among its related pathways are Unfolded Protein Response (UPR) and Transport to the Golgi and subsequent modification. An important paralog of this gene is YIF1B.

UniProtKB/Swiss-Prot for YIF1A Gene

  • Possible role in transport between endoplasmic reticulum and Golgi.

Gene Wiki entry for YIF1A Gene

No data available for Entrez Gene Summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for YIF1A Gene

Genomics for YIF1A Gene

Regulatory Elements for YIF1A Gene

Enhancers for YIF1A Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around YIF1A on UCSC Golden Path with GeneCards custom track

Promoters for YIF1A Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around YIF1A on UCSC Golden Path with GeneCards custom track

Genomic Location for YIF1A Gene

66,284,580 bp from pter
66,289,170 bp from pter
4,591 bases
Minus strand

Genomic View for YIF1A Gene

Genes around YIF1A on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
YIF1A Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for YIF1A Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for YIF1A Gene

Proteins for YIF1A Gene

  • Protein details for YIF1A Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Protein YIF1A
    Protein Accession:
    Secondary Accessions:
    • A6NM00
    • Q96G83
    • Q9BVD0

    Protein attributes for YIF1A Gene

    293 amino acids
    Molecular mass:
    32011 Da
    Quaternary structure:
    • Interacts with YIPF5.

neXtProt entry for YIF1A Gene

Proteomics data for YIF1A Gene at MOPED

Post-translational modifications for YIF1A Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for YIF1A Gene

Domains & Families for YIF1A Gene

Gene Families for YIF1A Gene

Protein Domains for YIF1A Gene


Suggested Antigen Peptide Sequences for YIF1A Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the YIF1 family.
  • Belongs to the YIF1 family.
genes like me logo Genes that share domains with YIF1A: view

Function for YIF1A Gene

Molecular function for YIF1A Gene

UniProtKB/Swiss-Prot Function:
Possible role in transport between endoplasmic reticulum and Golgi.

Phenotypes for YIF1A Gene

genes like me logo Genes that share phenotypes with YIF1A: view

Animal Model Products

miRNA for YIF1A Gene

miRTarBase miRNAs that target YIF1A

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for YIF1A Gene

Localization for YIF1A Gene

Subcellular locations from UniProtKB/Swiss-Prot for YIF1A Gene

Endoplasmic reticulum membrane; Multi-pass membrane protein. Golgi apparatus membrane; Multi-pass membrane protein. Note=Cycles between the endoplasmic reticulum and the endoplasmic reticulum-Golgi intermediate compartment. {ECO:0000269 PubMed:15308636}.

Subcellular locations from

Jensen Localization Image for YIF1A Gene COMPARTMENTS Subcellular localization image for YIF1A gene
Compartment Confidence
cytoskeleton 5
endoplasmic reticulum 5
golgi apparatus 5
plasma membrane 3
cytosol 1
endosome 1
mitochondrion 1
vacuole 1

Gene Ontology (GO) - Cellular Components for YIF1A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000139 Golgi membrane IEA --
GO:0005789 endoplasmic reticulum membrane TAS --
GO:0005815 microtubule organizing center IDA --
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with YIF1A: view

Pathways & Interactions for YIF1A Gene

genes like me logo Genes that share pathways with YIF1A: view

Gene Ontology (GO) - Biological Process for YIF1A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0015031 protein transport IEA --
GO:0044267 cellular protein metabolic process TAS --
genes like me logo Genes that share ontologies with YIF1A: view

No data available for SIGNOR curated interactions for YIF1A Gene

Drugs & Compounds for YIF1A Gene

No Compound Related Data Available

Transcripts for YIF1A Gene

Unigene Clusters for YIF1A Gene

Yip1 interacting factor homolog A (S. cerevisiae):
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for YIF1A Gene

ExUns: 1a · 1b · 1c ^ 2a · 2b ^ 3 ^ 4a · 4b ^ 5 ^ 6 ^ 7a · 7b · 7c · 7d ^ 8a · 8b ^ 9a · 9b · 9c
SP1: - - - - -
SP2: - - - - - - -
SP3: - - - -
SP4: - - - - -
SP5: - -

Relevant External Links for YIF1A Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for YIF1A Gene

mRNA expression in normal human tissues for YIF1A Gene

Protein differential expression in normal tissues from HIPED for YIF1A Gene

This gene is overexpressed in Nasal epithelium (55.9).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for YIF1A Gene

SOURCE GeneReport for Unigene cluster for YIF1A Gene Hs.446445

genes like me logo Genes that share expression patterns with YIF1A: view

Protein tissue co-expression partners for YIF1A Gene

- Elite partner

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for YIF1A Gene

Orthologs for YIF1A Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for YIF1A Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia YIF1A 35
  • 93.97 (n)
  • 96.93 (a)
YIF1A 36
  • 97 (a)
(Canis familiaris)
Mammalia YIF1A 35
  • 92.95 (n)
  • 96.25 (a)
YIF1A 36
  • 96 (a)
(Mus musculus)
Mammalia Yif1a 35
  • 88.17 (n)
  • 92.49 (a)
Yif1a 16
Yif1a 36
  • 92 (a)
(Pan troglodytes)
Mammalia YIF1A 35
  • 99.89 (n)
  • 100 (a)
YIF1A 36
  • 100 (a)
(Rattus norvegicus)
Mammalia Yif1a 35
  • 87.94 (n)
  • 91.47 (a)
(Ornithorhynchus anatinus)
Mammalia YIF1A 36
  • 56 (a)
(Anolis carolinensis)
Reptilia YIF1A 36
  • 63 (a)
(Danio rerio)
Actinopterygii wufa11c09 35
yif1a 35
  • 64.79 (n)
  • 69.72 (a)
yif1a 36
  • 63 (a)
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.887 35
fruit fly
(Drosophila melanogaster)
Insecta CG5484 36
  • 28 (a)
(Caenorhabditis elegans)
Secernentea yif-1 35
  • 45.19 (n)
  • 38.73 (a)
yif-1 36
  • 24 (a)
A. gosspyii yeast
(Ashbya gossypii)
Saccharomycetes AGOS_AFR658W 35
  • 47.19 (n)
  • 33.13 (a)
K. lactis yeast
(Kluyveromyces lactis)
Saccharomycetes KLLA0C02563g 35
  • 37.02 (n)
  • 29.33 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes YIF1 35
  • 44.17 (n)
  • 38.04 (a)
YIF1 36
  • 19 (a)
(Oryza sativa)
Liliopsida Os06g0620600 35
  • 47.13 (n)
  • 36.74 (a)
bread mold
(Neurospora crassa)
Ascomycetes NCU00624 35
  • 47.15 (n)
  • 35.36 (a)
fission yeast
(Schizosaccharomyces pombe)
Schizosaccharomycetes hrf1 35
  • 43.36 (n)
  • 35.59 (a)
Species with no ortholog for YIF1A:
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)

Evolution for YIF1A Gene

Gene Tree for YIF1A (if available)
Gene Tree for YIF1A (if available)

Paralogs for YIF1A Gene

Paralogs for YIF1A Gene

(1) SIMAP similar genes for YIF1A Gene using alignment to 7 proteins:

genes like me logo Genes that share paralogs with YIF1A: view

Variants for YIF1A Gene

Sequence variations from dbSNP and Humsavar for YIF1A Gene

SNP ID Clin Chr 11 pos Sequence Context AA Info Type
rs565468 -- 66,287,622(+) GGCGT(A/T)GAGGT reference, missense
rs1144800 -- 66,286,348(-) tgagc(C/T)actgc intron-variant, utr-variant-3-prime
rs2282567 -- 66,285,164(+) GACCC(A/C)CTTCT intron-variant
rs2282568 -- 66,285,361(+) CTCCC(A/C/G)CTGGC intron-variant, downstream-variant-500B
rs11544832 -- 66,288,214(-) CCAGC(C/T)CGGGG reference, missense

Structural Variations from Database of Genomic Variants (DGV) for YIF1A Gene

Variant ID Type Subtype PubMed ID
dgv1187n71 CNV Loss 21882294
nsv897772 CNV Loss 21882294
dgv1188n71 CNV Loss 21882294
nsv897779 CNV Loss 21882294
nsv825956 CNV Gain 20364138

Variation tolerance for YIF1A Gene

Residual Variation Intolerance Score: 80.7% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.76; 47.02% of all genes are more intolerant (likely to be disease-causing)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Relevant External Links for YIF1A Gene

Disorders for YIF1A Gene

Relevant External Links for YIF1A

Atlas of Genetics and Cytogenetics in Oncology and Haematology:

No disorders were found for YIF1A Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for YIF1A Gene

Publications for YIF1A Gene

  1. YIPF5 and YIF1A recycle between the ER and the Golgi apparatus and are involved in the maintenance of the Golgi structure. (PMID: 18718466) Yoshida Y. … Nakamura N. (Exp. Cell Res. 2008) 2 3 67
  2. A novel Golgi membrane protein is part of a GTPase-binding protein complex involved in vesicle targeting. (PMID: 10970842) Matern H. … Gallwitz D. (EMBO J. 2000) 2 3
  3. The GDP/GTP cycle of Rab5 in the regulation of endocytotic membrane traffic. (PMID: 8824393) Vitale G. … Zerial M. (Cold Spring Harb. Symp. Quant. Biol. 1995) 2 3
  4. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 3
  5. A human interactome in three quantitative dimensions organized by stoichiometries and abundances. (PMID: 26496610) Hein M.Y. … Mann M. (Cell 2015) 3

Products for YIF1A Gene

Sources for YIF1A Gene