Free for academic non-profit institutions. Other users need a Commercial license

Aliases for YIF1A Gene

Aliases for YIF1A Gene

  • Yip1 Interacting Factor Homolog A (S. Cerevisiae) 2 3
  • YIF1 3 4 6
  • YIP1-Interacting Factor Homolog A 3 4
  • 54TMp 3 4
  • 54TM 3 4
  • Yip1 Interacting Factor Homolog (S. Cerevisiae) 2
  • Putative Transmembrane Protein 54TMp 3
  • Putative Rab5-Interacting Protein 3
  • Yip1p-Interacting Factor 3
  • Protein YIF1A 3
  • FinGER7 3
  • HYIF1P 4
  • YIF1P 3

External Ids for YIF1A Gene

Previous Symbols for YIF1A Gene

  • YIF1

Summaries for YIF1A Gene

GeneCards Summary for YIF1A Gene

YIF1A (Yip1 Interacting Factor Homolog A (S. Cerevisiae)) is a Protein Coding gene. Among its related pathways are Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein and Unfolded Protein Response. An important paralog of this gene is YIF1B.

UniProtKB/Swiss-Prot for YIF1A Gene

  • Possible role in transport between endoplasmic reticulum and Golgi.

Gene Wiki entry for YIF1A Gene

No data available for Entrez Gene Summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for YIF1A Gene

Genomics for YIF1A Gene

Genomic Location for YIF1A Gene

Start:
66,284,580 bp from pter
End:
66,289,170 bp from pter
Size:
4,591 bases
Orientation:
Minus strand

Genomic View for YIF1A Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for YIF1A Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for YIF1A Gene

Regulatory Elements for YIF1A Gene

Proteins for YIF1A Gene

  • Protein details for YIF1A Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    O95070-YIF1A_HUMAN
    Recommended name:
    Protein YIF1A
    Protein Accession:
    O95070
    Secondary Accessions:
    • A6NM00
    • Q96G83
    • Q9BVD0

    Protein attributes for YIF1A Gene

    Size:
    293 amino acids
    Molecular mass:
    32011 Da
    Quaternary structure:
    • Interacts with YIPF5.

neXtProt entry for YIF1A Gene

Proteomics data for YIF1A Gene at MOPED

Post-translational modifications for YIF1A Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for YIF1A Gene

No data available for DME Specific Peptides for YIF1A Gene

Domains for YIF1A Gene

Protein Domains for YIF1A Gene

InterPro:
ProtoNet:

UniProtKB/Swiss-Prot:

YIF1A_HUMAN
Family:
  • Belongs to the YIF1 family.:
    • O95070
genes like me logo Genes that share domains with YIF1A: view

No data available for Gene Families for YIF1A Gene

Function for YIF1A Gene

Molecular function for YIF1A Gene

UniProtKB/Swiss-Prot Function: Possible role in transport between endoplasmic reticulum and Golgi.

Gene Ontology (GO) - Molecular Function for YIF1A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 22645275
genes like me logo Genes that share ontologies with YIF1A: view

miRNA for YIF1A Gene

miRTarBase miRNAs that target YIF1A

No data available for Enzyme Numbers (IUBMB) , Phenotypes , Animal Models , Transcription Factor Targeting and HOMER Transcription for YIF1A Gene

Localization for YIF1A Gene

Subcellular locations from UniProtKB/Swiss-Prot for YIF1A Gene

Endoplasmic reticulum membrane; Multi-pass membrane protein. Golgi apparatus membrane; Multi-pass membrane protein. Note=Cycles between the endoplasmic reticulum and the endoplasmic reticulum-Golgi intermediate compartment.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for YIF1A Gene COMPARTMENTS Subcellular localization image for YIF1A gene
Compartment Confidence
endoplasmic reticulum 5
golgi apparatus 5
cytoskeleton 4
plasma membrane 3
cytosol 1
mitochondrion 1

Gene Ontology (GO) - Cellular Components for YIF1A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000139 Golgi membrane IEA --
GO:0005789 endoplasmic reticulum membrane TAS --
GO:0005793 endoplasmic reticulum-Golgi intermediate compartment IDA 15308636
GO:0005794 Golgi apparatus IDA --
GO:0005815 microtubule organizing center IDA --
genes like me logo Genes that share ontologies with YIF1A: view

Pathways for YIF1A Gene

genes like me logo Genes that share pathways with YIF1A: view

Gene Ontology (GO) - Biological Process for YIF1A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006987 activation of signaling protein activity involved in unfolded protein response --
GO:0015031 protein transport IEA --
GO:0016192 vesicle-mediated transport IEA --
GO:0030968 endoplasmic reticulum unfolded protein response TAS --
GO:0036498 IRE1-mediated unfolded protein response TAS --
genes like me logo Genes that share ontologies with YIF1A: view

Transcripts for YIF1A Gene

Unigene Clusters for YIF1A Gene

Yip1 interacting factor homolog A (S. cerevisiae):
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for YIF1A Gene

ExUns: 1a · 1b · 1c ^ 2a · 2b ^ 3 ^ 4a · 4b ^ 5 ^ 6 ^ 7a · 7b · 7c · 7d ^ 8a · 8b ^ 9a · 9b · 9c
SP1: - - - - -
SP2: - - - - - - -
SP3: - - - -
SP4: - - - - -
SP5: - -
SP6:
SP7:

Relevant External Links for YIF1A Gene

GeneLoc Exon Structure for
YIF1A
ECgene alternative splicing isoforms for
YIF1A

Expression for YIF1A Gene

mRNA expression in normal human tissues for YIF1A Gene

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for YIF1A Gene

SOURCE GeneReport for Unigene cluster for YIF1A Gene Hs.446445

genes like me logo Genes that share expressions with YIF1A: view

Orthologs for YIF1A Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for YIF1A Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia YIF1A 36
  • 99.89 (n)
  • 100 (a)
YIF1A 37
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia YIF1A 36
  • 93.97 (n)
  • 96.93 (a)
YIF1A 37
  • 97 (a)
OneToOne
dog
(Canis familiaris)
Mammalia YIF1A 36
  • 92.95 (n)
  • 96.25 (a)
YIF1A 37
  • 96 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Yif1a 36
  • 88.17 (n)
  • 92.49 (a)
Yif1a 16
Yif1a 37
  • 92 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia YIF1A 37
  • 56 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Yif1a 36
  • 87.94 (n)
  • 91.47 (a)
lizard
(Anolis carolinensis)
Reptilia YIF1A 37
  • 63 (a)
OneToOne
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.887 36
zebrafish
(Danio rerio)
Actinopterygii wufa11c09 36
yif1a 36
  • 64.79 (n)
  • 69.72 (a)
yif1a 37
  • 63 (a)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta CG5484 37
  • 28 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea yif-1 36
  • 45.19 (n)
  • 38.73 (a)
yif-1 37
  • 24 (a)
OneToMany
A. gosspyii yeast
(Ashbya gossypii)
Saccharomycetes AGOS_AFR658W 36
  • 47.19 (n)
  • 33.13 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes YIF1 36
  • 44.17 (n)
  • 38.04 (a)
YIF1 37
  • 19 (a)
OneToMany
K. lactis yeast
(Kluyveromyces lactis)
Saccharomycetes KLLA0C02563g 36
  • 37.02 (n)
  • 29.33 (a)
rice
(Oryza sativa)
Liliopsida Os06g0620600 36
  • 47.13 (n)
  • 36.74 (a)
bread mold
(Neurospora crassa)
Ascomycetes NCU00624 36
  • 47.15 (n)
  • 35.36 (a)
fission yeast
(Schizosaccharomyces pombe)
Schizosaccharomycetes hrf1 36
  • 43.36 (n)
  • 35.59 (a)
Species with no ortholog for YIF1A:
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)

Evolution for YIF1A Gene

ENSEMBL:
Gene Tree for YIF1A (if available)
TreeFam:
Gene Tree for YIF1A (if available)

Paralogs for YIF1A Gene

Paralogs for YIF1A Gene

Selected SIMAP similar genes for YIF1A Gene using alignment to 7 proteins:

genes like me logo Genes that share paralogs with YIF1A: view

Variants for YIF1A Gene

Sequence variations from dbSNP and Humsavar for YIF1A Gene

SNP ID Clin Chr 11 pos Sequence Context AA Info Type MAF
rs11957 -- 66,284,887(+) CATGA(A/G)CGCCG reference, missense
rs510398 -- 66,287,352(-) GGACT(A/G)TATCC intron-variant
rs565468 -- 66,287,622(+) GGCGT(A/T)GAGGT reference, missense
rs1144800 -- 66,286,348(-) tgagc(C/T)actgc intron-variant
rs2282567 -- 66,285,164(+) GACCC(A/C)CTTCT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for YIF1A Gene

Variant ID Type Subtype PubMed ID
dgv1187n71 CNV Loss 21882294
nsv897772 CNV Loss 21882294
dgv1188n71 CNV Loss 21882294
nsv897779 CNV Loss 21882294
nsv825956 CNV Gain 20364138

Relevant External Links for YIF1A Gene

HapMap Linkage Disequilibrium report
YIF1A

Disorders for YIF1A Gene

No disorders were found for YIF1A Gene.

No data available for UniProtKB/Swiss-Prot for YIF1A Gene

Publications for YIF1A Gene

  1. The GDP/GTP cycle of Rab5 in the regulation of endocytotic membrane traffic. (PMID: 8824393) Vitale G. … Zerial M. (Cold Spring Harb. Symp. Quant. Biol. 1995) 2 3
  2. A novel Golgi membrane protein is part of a GTPase-binding protein complex involved in vesicle targeting. (PMID: 10970842) Matern H. … Gallwitz D. (EMBO J. 2000) 2 3
  3. Proteomics of endoplasmic reticulum-Golgi intermediate compartment (ERGIC) membranes from brefeldin A-treated HepG2 cells identifies ERGIC-32, a new cycling protein that interacts with human Erv46. (PMID: 15308636) Breuza L. … Hauri H.-P. (J. Biol. Chem. 2004) 3 4
  4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4
  5. Human Yip1A specifies the localization of Yif1 to the Golgi apparatus. (PMID: 15990086) Jin C. … Yao X. (Biochem. Biophys. Res. Commun. 2005) 3 4

Products for YIF1A Gene

Sources for YIF1A Gene

Back to Top

Content