YES1 Gene
protein-coding GIFtS: 70
GCID: GC18M000721
|
|
v-yes-1 Yamaguchi sarcoma viral oncogene homolog 1
| |
Aliases
for YES1 gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| V-Yes-1 Yamaguchi Sarcoma Viral Oncogene Homolog 11 2 | | Cellular Yes-1 Protein2 | | HsT4411 2 | | Proto-Oncogene Tyrosine-Protein Kinase YES2 | | Yes1 2 | | Tyrosine-Protein Kinase Yes2 | | C-Yes1 | | Yamaguchi Sarcoma Oncogene2 | | Proto-Oncogene C-Yes2 3 | | YES3 | | EC 2.7.10.23 8 | | P61-Yes1 | | P61-YES2 | | EC 2.7.108 |
Export aliases for YES1 gene to outside databasesPrevious GC identifers: GC22P022739 GC18M000709 GC18M000711 |
Summaries
for YES1 gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
Entrez Gene summary for YES1:
This gene is the cellular homolog of the Yamaguchi sarcoma virus oncogene. The encoded protein has tyrosine kinaseactivity and belongs to the src family of proteins. This gene lies in close proximity to thymidylate synthase gene onchromosome 18, and a corresponding pseudogene has been found on chromosome 22. (provided by RefSeq, Jul 2008)
UniProtKB/Swiss-Prot: YES_HUMAN, P07947Function: Non-receptor protein tyrosine kinase that is involved in the regulation of cell growth and survival,apoptosis, cell-cell adhesion, cytoskeleton remodeling, and differentiation. Stimulation by receptor tyrosine kinases(RTKs) including EGRF, PDGFR, CSF1R and FGFR leads to recruitment of YES1 to the phosphorylated receptor, andactivation and phosphorylation of downstream substrates. Upon EGFR activation, promotes the phosphorylation of PARD3to favor epithelial tight junction assembly. Participates in the phosphorylation of specific junctional componentssuch as CTNND1 by stimulating the FYN and FER tyrosine kinases at cell-cell contacts. Upon T-cell stimulation byCXCL12, phosphorylates collapsin response mediator protein 2/DPYSL2 and induces T-cell migration. Participates inCD95L/FASLG signaling pathway and mediates AKT-mediated cell migration. Plays a role in cell cycle progression byphosphorylating the cyclin-dependent kinase 4/CDK4 thus regulating the G1 phase. Also involved in G2/M progression andcytokinesis
Gene Wiki entry for YES1
|
Genomic Views
for YES1 gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000018.9 NC_018929.1 NT_010859.14
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the YES1 gene promoter:
SRF Pax-5 FOXO4 SRF (504 AA) IRF-7A NF-kappaB NF-kappaB1 En-1
Other transcription factors
Search SABiosciences Chromatin IP Primers for YES1
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat YES1 |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 18p11.31-p11.21 Ensembl cytogenetic band: 18p11.32 HGNC cytogenetic band: 18p11.31-p11.21YES1 Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 18 GeneLoc Exon Structure GeneLoc location for GC18M000721: view genomic region
(about GC identifiers)
Start:
|
721,588 bp from pter |
End:
|
812,547 bp from pter |
Size:
|
90,960 bases |
Orientation:
|
minus strand |
|
Proteins
for YES1 gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: YES_HUMAN, P07947 (See
protein sequence)Recommended Name: Tyrosine-protein kinase Yes Size: 543 amino acids; 60801 Da
Subunit: Interacts with YAP1 and CSF1R (By similarity). Interacts with CTNND1; this interaction allows YES1-mediatedactivation of FYN and FER and subsequent phosphorylation of CTNND1 (By similarity). Interacts with FASLG
Subcellular location: Cell membrane. Cytoplasm, cytoskeleton, centrosome. Cytoplasm, cytosol. Note=Newly synthesizedprotein initially accumulates in the Golgi region and traffics to the plasma membrane through the exocytic pathway
1 PDB 3D structure from  and Proteopedia  for YES1:2HDA (3D)
Secondary accessions: A6NLB3 D3DUH1Explore the universe of human proteins at neXtProt for YES1: NX_P07947
Post-translational modifications:
Phosphorylation by CSK on the C-terminal tail maintains the enzyme in an inactive state. Autophosphorylation at Tyr-426maintains enzyme activity by blocking CSK-mediated inhibition1
Palmitoylation at Cys-3 promotes membrane localization (By similarity)1
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_P07947
4/39 DME Specific Peptides for YES1 (P07947) (see all 39)
YES1 Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins: NP_005424.1
ENSEMBL proteins: ENSP00000464380 ENSP00000462468 ENSP00000324740 Reactome Protein details: P07947
Human Recombinant Protein Products:
Gene Ontology (GO): 5 cellular component terms (GO ID links to tree view): About this table
YES1 for ontologies About GeneDecksing
YES1 Antibody Products:
Assay Products for YES1: |
Protein
Domains /
Families
for YES1 gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
YES1 for domains About GeneDecksing
5/8 InterPro domains/families (see all 8):Graphical View of Domain Structure for InterPro Entry P07947ProtoNet protein and cluster: P07947 3 Blocks protein families: IPB000980 SH2 domain signature IPB001452 SH3 domain signature IPB008266 Tyrosine protein kinase
UniProtKB/Swiss-Prot: YES_HUMAN, P07947Similarity: Belongs to the protein kinase superfamily. Tyr protein kinase family. SRC subfamilySimilarity: Contains 1 protein kinase domainSimilarity: Contains 1 SH2 domainSimilarity: Contains 1 SH3 domain |
Function
for YES1 gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Function Summary:
UniProtKB/Swiss-Prot: YES_HUMAN, P07947Function: Non-receptor protein tyrosine kinase that is involved in the regulation of cell growth and survival,apoptosis, cell-cell adhesion, cytoskeleton remodeling, and differentiation. Stimulation by receptor tyrosine kinases(RTKs) including EGRF, PDGFR, CSF1R and FGFR leads to recruitment of YES1 to the phosphorylated receptor, andactivation and phosphorylation of downstream substrates. Upon EGFR activation, promotes the phosphorylation of PARD3to favor epithelial tight junction assembly. Participates in the phosphorylation of specific junctional componentssuch as CTNND1 by stimulating the FYN and FER tyrosine kinases at cell-cell contacts. Upon T-cell stimulation byCXCL12, phosphorylates collapsin response mediator protein 2/DPYSL2 and induces T-cell migration. Participates inCD95L/FASLG signaling pathway and mediates AKT-mediated cell migration. Plays a role in cell cycle progression byphosphorylating the cyclin-dependent kinase 4/CDK4 thus regulating the G1 phase. Also involved in G2/M progression andcytokinesisCatalytic activity: ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate Genatlas biochemistry entry for YES1:Yamaguchi sarcoma viral (v-yes-1) oncogene homolog 1
Enzyme Numbers (IUBMB): EC 2.7.10.21 2 EC 2.7.102
Clone
Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for YES1 (see all 3)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for YES1 (see all 2)
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling 
| |  | GenScript: all cDNA clones in your preferred vector: YES1 (NM_005433) | |  | Browse Sino Biological Human cDNA Clones | |  | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for YES1 | |  | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat YES1 |
In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for YES1 |
Gene Ontology (GO): 5/7 molecular function terms (GO ID links to tree view) (see all 7): About this table
YES1 for ontologies About GeneDecksing
4 GenomeRNAi human phenotypes for YES1:
Animal Models:
Mouse knock-out Yes1tm1Sor for YES1
11 MGI mutant phenotypes (inferred from 2 alleles ) (MGI details for Yes1):
YES1 for phenotypes About GeneDecksing
|
Pathways & Interactions
for YES1 gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Unified GeneCards pathways - 5/39 super-pathways (see all 39) About this table
See pathways by source
| Super-pathway | contained gene-specific pathways |
|---|
| 1 | Phosphorylation of GAB2 by SFKs | | | 2 | Immune System | | | 3 | CBL ubiquitinates PI3K | | | 4 | CD28 co-stimulation | | | 5 | Cleavage of Alpha-1-Microglobulin | |
Pathway sources
See GeneCards unified pathways
Show all pathways
1 EMD Millipore Pathway for YES1
1 Downloadable PowerPoint Slide of QIAGEN Pathway Central Maps for YES1
2 
Cell Signaling Technology (CST) Pathways for YES1
1  GeneGo (Thomson Reuters) Pathway for YES1
5/18  BioSystems Pathways for YES1 (see all 18)
5/23 
Reactome Pathways for YES1 (see all 23)
2 
Kegg Pathways (Kegg details for YES1):
YES1 for pathways About GeneDecksing
Interactions:
SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for YES1
STRING Interaction
Network Preview (showing 5 interactants - click image to see 25)
5/281 Interacting proteins for YES1 (P079472, 3 ENSP000003247404) via UniProtKB, MINT, STRING, and/or I2D (see all 281)| Interactant | Interaction Details |
|---|
| GeneCard | External ID(s) |
|---|
| PDGFRB | P096192, 3, ENSP000002617994 | MINT-8026872 MINT-8038029 I2D:
score=3 STRING: ENSP00000261799 | | MED28 | Q9H2042, 3, ENSP000002373804 | MINT-7041666 MINT-7041601 I2D:
score=1 STRING: ENSP00000237380 | | ADAM15 | Q134442, 3, ENSP000003494364 | MINT-2792392 I2D:
score=2 STRING: ENSP00000349436 | | PAK2 | Q131772, 3, ENSP000003140674 | MINT-2792076 I2D:
score=2 STRING: ENSP00000314067 | | PDCD6IP | Q8WUM42, 3, ENSP000003073874 | MINT-68502 I2D:
score=2 STRING: ENSP00000307387 |
About this table
Gene Ontology (GO): 5/7 biological process terms (GO ID links to tree view) (see all 7): About this table
YES1 for ontologies About GeneDecksing
|
Drugs & Compounds
for YES1 gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
YES1 for compounds About GeneDecksing
 |
Enzo Life Sciences drugs & compounds for YES1 |
 Browse Tocris compounds for YES1
2 HMDB Compounds for YES1 About this table
1 DrugBank Compound for YES1 About this table
5 Novoseek chemical compound relationships for YES1 gene About this table
Search CenterWatch for drugs/clinical trials and news about YES1 / YES
|
Transcripts
for YES1 gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for YES1 gene: NM_005433.3 Unigene Cluster for YES1: V-yes-1 Yamaguchi sarcoma viral oncogene homolog 1 Hs.194148 [show with all ESTs]Unigene Representative Sequence: NM_0054335 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000577961(uc002kky.3) ENST00000584307(uc002kkz.3) ENST00000314574
ENST00000577611 ENST00000581960
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for YES1 (see all 3)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for YES1 (see all 2)
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector: YES1 (NM_005433) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for YES1 | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat YES1 |
Additional cDNA sequence: AK314063.1 BC031080.1 BC048960.1 M15990.1 11 DOTS entries: DT.95156689 DT.416485 DT.95356709 DT.121087601 DT.100647936 DT.70105092 DT.121087580 DT.100785653 DT.100785654 DT.121087582 DT.91658947 24/174 AceView cDNA sequences (see all 174): N53374 NM_005433 BF438787 T28838 AI124049 AA126692 CB410797 BP360000 CB145677 BU753250 AA843100 AA345032 BG289848 BM837753 AL047403 BU753688 BG026275 AA130041 BI496989 BX110440 AL121509 AI873533 CA397481 AU116847
GeneLoc Exon Structure
|
Expression
for YES1 gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| YES1 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: AGATTTTTTA
About this image
See YES1 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for YES1
SOURCE GeneReport for Unigene cluster: Hs.194148
UniProtKB/Swiss-Prot: YES_HUMAN, P07947Tissue specificity: Expressed in the epithelial cells of renal proximal tubules and stomach as well as hematopoieticcells in the bone marrow and spleen in the fetal tissues. In adult, expressed in epithelial cells of the renalproximal tubules and present in keratinocytes in the basal epidermal layer of epidermis
SABiosciences Custom PCR Arrays for YES1
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for YES1
Browse OriGene validated miRNA SYBR primer pairs
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse, rat YES1 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat YES1 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat YES1 | In Situ
Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for YES1 |
Orthologs
for YES1 gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of animals.
Orthologs for YES1 gene from 6/21 species (see all 21) About this table
| Organism |
Taxonomic
classification |
Gene |
Description |
Human
Similarity |
Orthology
Type |
Details |
chicken
(Gallus gallus) |
Aves |
YES11 |
v-yes-1 Yamaguchi sarcoma viral oncogene homolog 1 |
84.47(n)
92.24(a) |
|
396238 NM_205301.1 NP_990632.1 |
lizard
(Anolis carolinensis) |
Reptilia |
YES16 |
-- |
91(a) |
1 ↔ 1 |
4(39553339-39568329) |
African clawed frog
(Xenopus laevis) |
Amphibia |
MGC684442 |
hypothetical protein MGC68444 |
81.27(n) |
|
BC049390.1 |
zebrafish
(Danio rerio) |
Actinopterygii |
yes11 |
v-yes-1 Yamaguchi sarcoma viral oncogene homolog 1 |
72.44(n)
86.37(a) |
|
407620 NM_001013270.2 NP_001013288.2 |
fruit fly
(Drosophila melanogaster) |
Insecta |
Src64B3 |
ring canal formation protein tyrosine kinase |
51(a) |
|
64B12 -- |
worm
(Caenorhabditis elegans) |
Secernentea |
src-13 |
Expression: vulva, anus, mu_bod, pharyngeal
muscle, more |
49(a)
(best of 4) |
|
I(1567610-1580076) -- |
ENSEMBL Gene Tree for YES1 (if available)
TreeFam Gene Tree for YES1 (if available) |
Paralogs
for YES1 gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| Paralogs for YES1 gene
- TEC2 FRK2 LCK2 BLK2 FGR2 ITK2 LYN2 TXK2
- HCK2 PTK62 SRC2 ABL12 FYN2 BMX2 ABL22 SRMS2
- BTK2
18/53 SIMAP similar genes for YES1 using alignment to 3 protein entries: YES_HUMAN (see all proteins)
(see all similar genes):SRC LYN BLK HCK FYN ABL1
FGR FRK LCK NCK2 EPHA2 GRAPL
ARHGEF7 BCR/ABL fusion BTK kinase deficient isoform 6 EPHA6 GRAP2 GRB2
YES1 for paralogs About GeneDecksing
1 Pseudogenes.org Pseudogene for YES1
PGOHUM00000246552
|
Genomic Variants
for YES1 gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 18 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for YES1 (721588 - 812547 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 1 variation for YES1
1 CNV: 5044 | SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing YES1 |
|
Disorders
/ Diseases
for YES1 gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database, Novoseek,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
YES1 for disorders About GeneDecksing
OMIM gene information: 164880
OMIM disorders: --
20/22  diseases for YES1 (see all 22): About MalaCardssarcoma patellofemoral pain syndrome non-small cell lung carcinoma squamous cell carcinoma of the head and neck
squamous cell carcinoma inflammatory bowel disease familial pancreatic cancer paine syndrome
colon carcinoma colon cancer lung carcinoma pancreatic cancer
carcinoma skin cancer melanoma hepatocellular carcinoma
pancreatitis gastric cancer pharyngitis breast cancer
7 Novoseek disease relationships for YES1 gene About this table
Human Genome Epidemiology (HuGE) Navigator: YES1 (3 documents)
Tumor Gene Database (TGDB): YES1
Export disorders for YES1 gene to outside databases
|
Publications
for YES1 gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for YES1 gene, integrated from 9 sources (see all 146):
(articles sorted by number of sources associating them with YES1) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- CD46 is phosphorylated at tyrosine 354 upon infection of epithelial cells by Neisseria gonorrhoeae. (PubMed id 11901164)1, 2, 9 Lee S.W....So M. (2002)
- Differential trafficking of Src, Lyn, Yes and Fyn is specified by the state of palmitoylation in the SH4 domain. (PubMed id 19258394)1, 2 Sato I....Yamaguchi N. (2009)
- Identification of SH3 domain interaction partners of human FasL (CD178) by phage display screening. (PubMed id 19807924)1, 2 Voss M....Janssen O. (2009)
- Crystallographic structure of the SH3 domain of the human c-Yes tyrosine kinase: loop flexibility and amyloid aggregation. (PubMed id 17418139)1, 2 Martin-Garcia J.M....Camara-Artigas A. (2007)
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
- Autophosphorylation of Src and Yes blocks their inactivation by Csk phosphorylation. (PubMed id 9794236)1, 2 Sun G....Budde R.J. (1998)
- Differential expression of p62c-yes in normal, hyperplastic and neoplastic human epidermis. (PubMed id 2067846)1, 2 Krueger J....Sudol M. (1991)
- Characterization of cDNA clones for the human c-yes gene. (PubMed id 2436037)1, 2 Sukegawa J.... Toyoshima K. (1987)
- Location of the c-yes gene on the human chromosome and its expression in various tissues. (PubMed id 2983418)1, 3 Semba K....Toyoshima K. (1985)
- Identification of c-Yes expression in the nuclei of hepatocellular carcinoma cells: involvement in the early stages of hepatocarcinogenesis. (PubMed id 17143518)1, 9 Nonomura T....Kuriyama S. (2007)
|
External Searches for YES1 gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
|
Genome Databases showing YES1 gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing YES1 gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing YES1 gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
|
About This Section
| Patent Information for YES1 gene:
Search GeneIP for patents involving YES1
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for YES1 gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
About This Section
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| | |  | OriGene Antibodies for YES1 | | OriGene shRNA RFP for YES1 | | | OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for YES1 | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for YES1 | | | OriGene Protein Over-expression Lysate for YES1 | | Browse OriGene Fluorogenic Cell Assay Kits | | | OriGene siRNA for YES1 | | OriGene 3'-UTR Clone for YES1 | | | OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for YES1 | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for YES1 | | | Browse OriGene GFP tagged cDNA clones in CMV expression vector | | Browse OriGene MicroRNA Expression Plasmids | | | Browse OriGene basic RS shRNAs | | Browse OriGene validated miRNA SYBR primer pairs | | | OriGene Purified Protein for YES1 | | OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling | | | OriGene Custom Antibody Services for YES1 | | OriGene Custom Protein Services for YES1 | | | OriGene Custom Immunoassay Development | | |
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| | | QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat YES1 | | | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing YES1 | | | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat YES1 | | | QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat YES1 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat YES1 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat YES1 |
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| | Antibodies & Assays for YES1 (Yes) |
| | | | Search Tocris compounds for YES1 |
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 | | | YES1 Proteins, Antibodies, CLIAs, and ELISAs |
| | | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for YES1 |
|  |  |  | | | | ThermoFisher Antibodies for YES1 |
| | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat YES1 |
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