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YES1 Gene

protein-coding GIFtS: 69

GC18M000711

v-yes-1 Yamaguchi sarcoma viral oncogene homolog 1
Symbol approved by the HUGO Gene Nomenclature Committee (HGNC) database

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc , and/or ⁷Ensembl, ⁸miRBase)
About This Section

Aliases
EC 2.7.10.2 ^³
HsT441 ^¹, ²
OTTHUMP00000162194 ^²
P61-YES ^²
YES ^³
Yes ^¹, ²
c-Yes ^³
c-yes ^¹, ²
p61-Yes ^³

Descriptions
Yamaguchi sarcoma oncogene ^²
cellular yes-1 protein ^²
proto-oncogene tyrosine-protein kinase YES ^²
v-yes-1 Yamaguchi sarcoma viral oncogene homolog 1 ^²
viral oncogene yes-1 homolog 1 ^²

External Ids
HGNC: 12841¹
Entrez Gene: 7525²
UniProtKB: P07947³
Ensembl: ENSG00000176105⁷

Search outside databases for aliases for YES1 gene

Previous GC identifers: GC22P022739 GC18M000709

(According to Entrez Gene, Wikipedia's Gene Wiki,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

EntrezGene summary for YES1:

This gene is the cellular homolog of the Yamaguchi sarcoma virus oncogene. The encoded protein has

tyrosine kinase activity and belongs to the src family of proteins. This gene lies in close

proximity to thymidylate synthase gene on chromosome 18, and a corresponding pseudogene has been

found on chromosome 22. [provided by RefSeq]

UniProtKB/Swiss-Prot: YES_HUMAN, P07947

Function: Promotes infectivity of Neisseria gonorrhoeae in epithelial cells by phosphorylating

MCP/CD46

Gene Wiki entry for YES1

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 36),
and/or miRBase,
Genomic Views according to UCSC and Ensembl, Transcription factor binding sites according to SABiosciences)
About This Section

Genomic View:

UCSC Golden Path with GeneCards custom track

Transcription factor binding sites upstream to the YES1 gene

Entrez Gene cytogenetic band: 18p11.31-p11.21 Ensembl cytogenetic band: 18p11.32 HGNC cytogenetic band: 18p11.31-p11.21

YES1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)

GeneLoc gene densities for chromosome 18 GeneLoc Exon Structure

GeneLoc location for GC18M000711: (about GC identifiers)

Start:	711,588 bp from pter
End:	802,327 bp from pter
Size:	90,740 bases
Orientation:	minus strand

RefSeq DNA sequence:

NC_000018.8 NT_010859.14

(According to ¹UniProtKB, and/or Ensembl, Phosphorylation sites according to ²Phosphosite, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Enzo Life Sciences, Abnova, OriGene and/or, Abcam,
Biochemical Assays by Invitrogen, Millipore, R&D Systems, Cell Signaling Technology, and/or Enzo Life Sciences, Ontologies according to Gene Ontology Consortium 01 Apr 2009 and Entrez Gene, Antibodies by Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Cell Signaling Technology, Abcam, Abnova, and/or Novus Biologicals)
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UniProtKB/Swiss-Prot: YES_HUMAN, P07947 (See protein sequence)

Recommended Name: Proto-oncogene tyrosine-protein kinase Yes

Size: 543 amino acids; 60801 Da

Subcellular location: Cytoplasm, cytosol. Note=In epithelial cells infected with Neisseria

gonorrhoeae, forms aggregates beneath bacterial microcolonies

PDB structures from and Proteopedia :

2HDA (3D)

Secondary accessions: A6NLB3

Post-translational modifications:

Autophosphorylated¹

View phosphorylation sites using PhosphoSite²

REFSEQ proteins: NP_005424.1

ENSEMBL proteins:

ENSP00000352892 ENSP00000324740

Human Recombinant Proteins

	Invitrogen human recombinant proteins for YES1
	Millipore Purified and/or Recombinant YES1 Protein
	Browse Human Recombinant Proteins at Sigma-Aldrich
	Browse R&D Systems for human recombinant proteins
	Browse recombinant and purified proteins available from Enzo Life Sciences
	Recombinant Proteins from Abcam (Yes1)
	Human Recombinant Proteins from Abnova (YES1)

OriGene Purified Recombinant Human Protein: YES1

2 Gene Ontology (GO) cellular component terms (links to tree view):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005624	membrane fraction	IEA	--
GO:0005737	cytoplasm	IEA	--

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Antibodies for YES1:

	Browse Antibodies Central at Invitrogen
	Millipore Mono- and Polyclonal Antibodies for the study of YES1
	Sigma-Aldrich Antibodies for YES1
	R&D Systems Antibodies for YES1 (Yes)
	Cell Signaling Technology (CST) Antibodies for YES1 (Yes)
	Antibodies from Abcam (Yes1), each with their Abpromise^SM
	Monoclonal and Polyclonal Antibodies from Abnova (YES1)
	Novus Biologicals Antibodies for YES1

Assays for YES1:

	Invitrogen Assays for YES1
	Millipore Kits and Assays for the Analysis of YES1
	R&D Systems ELISAs for YES1 (Yes) (see all)
	Browse biochemical assays available from Enzo Life Sciences

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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Graphical View of Domain Structure for InterPro Entry P07947

ProtoNet protein and cluster: P07947

3 Blocks protein families:

IPB000980 SH2 domain signature

IPB001452 SH3 domain signature

IPB008266 Tyrosine protein kinase

UniProtKB/Swiss-Prot: YES_HUMAN, P07947

Similarity: Belongs to the protein kinase superfamily. Tyr protein kinase family. SRC subfamily

Similarity: Contains 1 protein kinase domain

Similarity: Contains 1 SH2 domain

Similarity: Contains 1 SH3 domain

(According to MGI Jun 06 2009, UniProtKB, IUBMB,and/or Genatlas,
shRNA from OriGene, Sigma-Aldrich, RNAi from Sigma-Aldrich,
RNAi Products, Clones, and Q-PCR Products from Invitrogen, Millipore, OriGene, and/or Abnova, siRNAs from Applied Biosystems, SYBR primers from OriGene, Cell-based Assays from Millipore, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
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Inhib. RNA:		Invitrogen RNAi Products for gene knock-down (YES1)
		Millipore RNAi Products for the Analysis of YES1 Gene knock-down
		Abnova Chimera RNAi Products for Gene knock-down (YES1)

OriGene 29mer shRNA kit in GFP-retroviral vector: NM_005433

Applied Biosystems Silencer® siRNAs for YES1

Sigma-Aldrich siRNA and siRNA Panels for YES1

Sigma-Aldrich shRNA Panels and shRNA for YES1

Explore Sigma-Aldrich super-pooled esiRNAs

Clones:		Invitrogen Clones for YES1
		Browse Clones for the Expression of Recombinant Proteins Available from Millipore

OriGene GFP tagged cDNA clone in CMV expression vector: NM_005433
Myc/DDK tagged cDNA clone in CMV expression vector: NM_005433
untagged cDNA clones in CMV expression vector (see all 2): NM_005433

Primers:

Browse Quantitative PCR Central at Invitrogen for Q-PCR LUX™ Primers

OriGene genome-wide validated SYBR primer pairs: NM_005433

UniProtKB/Swiss-Prot: YES_HUMAN, P07947

Function: Promotes infectivity of Neisseria gonorrhoeae in epithelial cells by phosphorylating

MCP/CD46

Catalytic activity: ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate

Enzyme Number (IUBMB): EC 2.7.10.2

Genatlas biochemistry entry for YES1:

Yamaguchi sarcoma viral (v-yes-1) oncogene homolog 1

13 MGI mutant phenotypes (inferred from 2 alleles) (MGI details for Yes1):

growth/size	hematopoietic system	homeostasis/metabolism	immune system	lethality-postnatal
lethality-prenatal/perinatal	life span-post-weaning/aging	nervous system	normal	renal/urinary system
respiratory system	skeleton	skin/coat/nails

5 Gene Ontology (GO) molecular function terms (links to tree view):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0000166	nucleotide binding	IEA	--
GO:0004715	non-membrane spanning protein tyrosine kinase activity	IEA	--
GO:0005515	protein binding	IPI	1715582 17254967 18328427
GO:0005524	ATP binding	IEA	--
GO:0016740	transferase activity	IEA	--

About this table

(Pathways according to Invitrogen (maps by GeneGo), Millipore, Cell Signaling Technology, Sigma-Aldrich, KEGG and/or UniProtKB,
Sets of similar genes according to GeneDecks, Proteins Network according to SABiosciences, Interactions according to ¹UniProtKB, ²MINT, and/or ³STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
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2 Sigma-Aldrich "Your Favorite Gene" Pathways for YES1 (Your Favorite Gene powered by Ingenuity)

Fc&gamma
Reelin Signaling in Neurons

GeneDecks YES1 for the pathways selected above

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Gene Network Central^TM Interacting Genes and Proteins Network for YES1

5/86 Interacting proteins for YES1 (P07947^{1, 2} ENSP00000324740³) via UniProtKB, MINT, and/or STRING (see all 86 )

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
GP6	Q9HCN6¹, ENSP00000308782³	EBI-515331, EBI-515278 STRING (score=.795)
RPL10P16	P27635², ENSP00000358825³	MINT-7146008 STRING (score=.757)
SLC9A3R1	O14745², ENSP00000262613³	MINT-72749 STRING (score=.728)
CDKN1B	P46527¹	EBI-515331, EBI-519280
FAS	P25445¹	EBI-515331, EBI-494743

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3 Gene Ontology (GO) biological process terms (links to tree view):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0006464	protein modification process	TAS	2436037
GO:0015758	glucose transport	IEA	--
GO:0046777	protein amino acid autophosphorylation	IEA	--

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(Chemical Compounds according to UniProtKB, Enzo Life Sciences, Sigma-Aldrich, Tocris Bioscience, and/or Novoseek and Drugs according to Enzo Life Sciences and/or PharmGKB)
About This Section

Browse drugs & compounds from Enzo Life Sciences

Browse Small Molecules at Sigma-Aldrich

Compounds for YES1 available from Tocris Bioscience
3 Novoseek chemical compound relationships for YES1 gene

Compound	Score	Articles	PubMed IDs for Articles with Shared Sentences (# sentences)
tyrosine	63.29	27	8246968 (4), 7690926 (2), 7478608 (2), 7690925 (2) (see all 17)
phosphotyrosine	48.15	1	8246968 (1)
threonine	15.37	1	8813150 (1)

About this table

(GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 219 Homo sapiens; Jun 2 2009) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView,
non coding RNAs according to RNAdb,
ESTs according to GeneTide,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from Invitrogen, Millipore, and/or Abnova,
siRNAs from Applied Biosystems, Sigma-Aldrich,
shRNA from Sigma-Aldrich, OriGene,
Tagged/untagged cDNA clones from OriGene,
Expression Assays from Applied Biosystems)
About This Section

Inhib. RNA:		Invitrogen RNAi Products for gene knock-down (YES1)
		Millipore RNAi Products for the Analysis of YES1 Gene knock-down
		Abnova Chimera RNAi Products for Gene knock-down (YES1)

OriGene 29mer shRNA kit in GFP-retroviral vector: NM_005433

Sigma-Aldrich siRNA and siRNA Panels for YES1

Sigma-Aldrich shRNA Panels and shRNA for YES1

Explore Sigma-Aldrich super-pooled esiRNAs

Applied Biosystems Silencer® siRNAs:

NM_005433

REFSEQ mRNAs for YES1 gene:

NM_005433.3

Applied Biosystems TaqMan ® Gene Expression Assays:

NM_005433

              OriGene GFP tagged cDNA clone in CMV expression vector: NM_005433
                                 Myc/DDK tagged cDNA clone in CMV expression vector: NM_005433
                                 untagged cDNA clones in CMV expression vector (see all 2): NM_005433

Additional cDNA sequence:

AK314063.1 BC031080.1 BC048960.1 M15990.1

11 DOTS entries:

DT.95156689 DT.416485 DT.95356709 DT.121087601 DT.100647936 DT.70105092 DT.121087580 DT.121087582

DT.91658947 DT.100785653 DT.100785654

24/174 AceView cDNA sequences (see all 174 ):

N53374 T28838 BP360000 BF438787 NM_005433 BU753250 AI124049 BG289848

AA345032 BM837753 AL047403 CB410797 CB145677 AA843100 AA126692 AA315217

BX503209 BP379820 AI628808 BM806670 AU140084 AW452094 BG119717 BF793664

highest scoring ESTs for YES1:

M15990 BC031080 BC048960 BI560649 BI861691 BQ932574 BX473018 AA125883 AA126584 AA126692

Unigene Cluster for YES1:

V-yes-1 Yamaguchi sarcoma viral oncogene homolog 1

Hs.194148 [show with all ESTs]

Unigene Representative Sequence: NM_005433

GeneLoc Exon Structure

2 Ensembl transcripts including schematic representations:

ENST00000359834 ENST00000314574

(Experimental results according to ¹GeneNote and GNF BioGPS,
probe sets-to-genes annotations according to ²GeneAnnot , ³GeneTide , Sets of similar genes according to GeneDecks, Electronic Northern calculations according to data from UniGene (Build 219 Homo sapiens), SAGE tags according to CGAP, plus additional links to SOURCE, and/or GNF BioGPS, and/or EXPOLDB, and/or UniProtKB,
Expression Assays from Applied Biosystems )
About This Section

YES1 expression in normal and diseased human tissues

Applied Biosystems TaqMan ® Gene Expression Assays for YES1

¹ / ² / ³

7 probe-sets matching YES1 gene

Affymetrix probe-set	Array	# genes	Sensitivity	Specificity	Correlation	Length	Gb_Accession	Consensus	Uniqueness	Score	Rank
Affymetrix probe-set	Array	GeneAnnot data			GeneNote data		GeneTide data
1674_at²^{, 3}	U95-A	1	1.00	1.00	1.00	1.00	M15990	1.00	0.90	0.95	1
202932_at²^{, 3}	U133-A	1	1.00	1.00	--	--	NM_005433	0.60	1.00	0.82	1
202933_s_at²^{, 3}	U133-A	1	1.00	1.00	--	--	NM_005433	0.60	1.00	0.82	1
210917_at*²	U133-A	NULL	0.00	0.00	--	--	--	--	--	--	--
202932_at²	U133Plus2	1	1.00	1.00	--	--	--	--	--	--	--
202933_s_at²	U133Plus2	1	1.00	1.00	--	--	--	--	--	--	--
210917_at*²	U133Plus2	NULL	0.00	0.00	--	--	--	--	--	--	--

GeneDecks YES1 for binary patterns associated with the probe-sets selected above

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Data from

(Publications) and GNF BioGPS
About these images
About these images

CGAP SAGE TAG: AGATTTTTTA

SOURCE GeneReport for Unigene cluster: Hs.194148
Expression variation in blood from EXPOLDB for YES1

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD and/or ⁵MGI Jun 06 2009, with possible further links to Flybase and/or WormBase, Gene Trees according to Ensembl)
About This Section

Orthologs for YES1 gene from 5/12 species (see all 12 )

Organism	Gene	Locus	Description	Human Similarity	NCBI accessions
dog (Canis familiaris)	YES1¹	--	v-yes-1 Yamaguchi sarcoma viral oncogene homolog 1	94.39(n) 97.97(a)	490532 XM_547654.2 XP_547654.1
chimpanzee (Pan troglodytes)	YES1¹	--	v-yes-1 Yamaguchi sarcoma viral oncogene homolog 1	99.94(n) 100(a)	455322 XM_512048.2 XP_512048.2
cow (Bos taurus)	YES1¹	--	v-yes-1 Yamaguchi sarcoma viral oncogene homolog 1	91.87(n) 97.23(a)	507632 XM_584279.3 XP_584279.2
rat (Rattus norvegicus)	Yes1¹	--	Yamaguchi sarcoma viral (v-yes) oncogene homolog 1	91.04(n) 94.75(a)	24884 NM_033298.1 NP_150640.1
mouse (Mus musculus)	Yes1^{1, 5}	5 (18.20 cM)⁵	Yamaguchi sarcoma viral (v-yes) oncogene homolog 1^{1, 5}	91.37(n)¹ 96.3(a)¹	22612¹ NM_009535.2¹ NP_033561.1¹ AI323763⁵ AK035612⁵ (see all 12)

About this table Species with no ortholog for YES1

ENSEMBL Gene Tree for YES1

(Paralogs according to ¹HomoloGene
and ²Ensembl, Pseudogenes according to ³Pseudogene.org)
About This Section

Paralogs for YES1 gene

SRC² FYN² FGR²

(According to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, and UniProtKB, Linkage Disequilibrium by HapMap, Genotyping Reagents from Applied Biosystems)
About This Section

10/603 NCBI SNPs in YES1 are shown (see all 603 )
(Click for Applied Biosystems TaqMan ® Genotyping Assay) (see all 130)

AB	SNP ID	Valid	Chr 18 pos	Sequence	Recs	AA Chg	Type	More	Recs	Pop	Total sample	More
AB	Genomic Data				Transcription Data				Allele Frequencies
				--	--	--		--	--			--
--	rs1060922^1,2	A,C,F,H,O	712402(-)	`ATGGCA/GTATAT`	1	--	ut3¹		13	MN EA NA EU WA	1226
	rs7233932^1,2	A,C,F,H	802713(+)	`CGATTC/GTGCCC`	1	--	ng3¹		3	EU NA	302
	rs9945303^1,2	A,C,F,H	803557(+)	`AGGAAA/GTGCAT`	1	--	ng3¹		3	EU EA	248
	rs9945495^1,2	A,C,F,H	803788(+)	`AGATAA/TTTTCG`	1	--	ng3¹		4	EU EA WA	406
--	rs1061035^1,2	C,F,H	712118(-)	`AAATCT/CAATCA`	1	--	ut3¹		7	MN EU WA EA	808
	rs9954727^1,2	A,C,H	803622(+)	`TAGGCG/ATTAAA`	1	--	ng3¹		4	EU EA WA	400
	rs6506474^1,2	A,C,F	711198(+)	`TTTAAA/GAAGAA`	1	--	ng5¹		3	NA	134
	rs9954735^1,2	A,C,H	803630(+)	`AAAGAG/TACACA`	1	--	ng3¹		4	EU EA WA	406
	rs9951100^1,2	A,F,H	804149(+)	`ATTACT/CACATT`	1	--	ng3¹ tfbs³		3	EU EA	262
	rs4121508^1,2	A,C,F	803554(+)	`TTAAGA/GAAATG`	1	--	ng3¹		5	MN EA NA	398

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HapMap Linkage Disequilibrium images for YES1 (up to first 250kb)

(in which this Gene is Involved, According to OMIM, UniProtKB, Novoseek, PharmGKB, Genatlas, GeneTests, Blood group antigen gene mutations by BGMUT, HGMD, GAD, HuGE Navigator, BCGD, and/or TGDB.)
About This Section

OMIM: 164880

7 Novoseek disease relationships for YES1 gene

Disease	Score	Articles	PubMed IDs for Articles with Shared Sentences (# sentences)
colon cancer	33.89	2	8674385 (1), 9690379 (1)
mammary tumor	32.84	4	10027159 (2), 7478608 (1)
colon carcinoma	29.52	2	7690925 (2)
cancer	20.31	4	17143518 (2), 17898870 (1)
carcinoma	17.23	1	7690925 (1)
tumors	4.92	7	10027159 (3), 8674385 (1), 17898870 (1), 17143518 (1) (see all 5)
melanoma	0.13	7	9681823 (3), 7690926 (3)

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Human Genome Epidemiology Navigator: YES1 (1 document)
Tumor Gene Database: YES1

(Possibly Related Articles in Doctor's Guide)
About This Section

(in PubMed. Associations of this gene to articles via ¹Novoseek, ²HGNC, ³Entrez Gene, ⁴UniProtKB/Swiss-Prot, ⁵UniProtKB/TrEMBL, ⁶GAD, and/or ⁷PharmGKB)
About This Section

10/105 PubMed articles for YES1 gene (see all 105 ):

CD46 is phosphorylated at tyrosine 354 upon infection of epithelial cells by Neisseria gonorrhoeae. (PubMed id 11901164)^{1, 3, 4} Lee S.W....So M. (2002)
Crystallographic structure of the SH3 domain of the human c-Yes tyrosine kinase: loop flexibility and amyloid aggregation. (PubMed id 17418139)^{3, 4} Martin-Garcia J.M....Camara-Artigas A. (2007)
Proteomics analysis of protein kinases by target class-selective prefractionation and tandem mass spectrometry. (PubMed id 17192257)^{3, 4} Wissing J.... Daub H. (2007)
Global, in vivo, and site-specific phosphorylation dynamics in signaling networks. (PubMed id 17081983)^{3, 4} Olsen J.V....Mann M. (2006)
Immunoaffinity profiling of tyrosine phosphorylation in cancer cells. (PubMed id 15592455)^{3, 4} Rush J.... Comb M.J. (2005)
Time-resolved mass spectrometry of tyrosine phosphorylation sites in the epidermal growth factor receptor signaling network reveals dynamic modules. (PubMed id 15951569)^{3, 4} Zhang Y.... White F.M. (2005)
Quantitative phosphoproteome analysis using a dendrimer conjugation chemistry and tandem mass spectrometry. (PubMed id 16094384)^{3, 4} Tao W.A.... Aebersold R. (2005)
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)^{3, 4} Gerhard D.S....Malek J. (2004)
Characterization of cDNA clones for the human c-yes gene. (PubMed id 2436037)^{3, 4} Sukegawa J.... Toyoshima K. (1987)
Location of the c-yes gene on the human chromosome and its expression in various tissues. (PubMed id 2983418)^{2, 3} Semba K....Toyoshima K. (1985)

(in PubMed, OMIM, and NCBI Bookshelf)
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		AND	OR
Aliases
Free Text

Query String		PubMed OMIM NCBI Bookshelf
	(Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, and/or H-InvDB)
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Entrez Gene: 7525	HGNC: 12841	AceView: YES1	Ensembl:ENSG00000176105	euGenes: HUgn7525
ECgene: YES1	H-InvDB: YES1

(According to HUGE)
About This Section

(According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section

Name	Description
ATLAS Chromosomes in Cancer entry for YES1	Genetics and Cytogenetics in Oncology and Haematology

Licensable Technologies for YES1
(Available from WIS Yeda, Salk, Tufts)

About This Section

(Reagents available from Applied Biosystems, Antibodies and assays by Cell Signaling Technology, Abcam, Novus Biologicals,
Sigma-Aldrich, R&D Systems, Millipore, Abnova, and/or Invitrogen, Clones available from OriGene,and/or Invitrogen, Drugs and/or compounds by Sigma-Aldrich,
Enzo Life Sciences, and/or Tocris Bioscience)
About This Section

Products for YES1:

TaqMan ® Gene Expression Assays

TaqMan ® Genotyping Assays

Free SNP selection tool

Invitrogen iPath Pathways	Invitrogen BLOCK-iT™ RNAi
Invitrogen Antibodies	Invitrogen Assays
Invitrogen Clones	Invitrogen Q-PCR Products
Invitrogen Human Recombinant Kinases	Invitrogen Custom Antibody and Peptide Service
Invitrogen Proteins / Assays / Screening Services	Search Invitrogen catalog for YES1-related products

	Millipore Custom Antibody & Bulk Services
	Millipore Preclinical / Clinical Development Services
	Millipore Immunoassay Services
	Millipore Target Screening & Profiling Services

	Predesigned and custom siRNAs for YES1		Antibodies for YES1
	Explore super-pooled esiRNAs		Browse proteins at Sigma-Aldrich
	Lentivirus-delivered shRNAs for YES1		Browse small molecules at Sigma-Aldrich
	"Your Favorite Gene" Pathways		feedback

	Antibodies		Primer Pairs
	Cell Culture Products		ELISAs
	Flow Cytometry Kits		Protease Activity Assays & Reagents
	Cell Selection/Detection Kits & Reagents		ELISA/Assay Development Kits & Reagents
	Multiplex/Array Assay Kits & Reagents		ELISpot Kits & Development Modules
	Recombinant & Natural Proteins

	Recombinant Proteins (YES1)
	Antibodies (YES1)
	Chimera RNAi (YES1)
	Custom Service for Mouse Mab
	Custom Service for Rabbit Pab from Full-length Protein

Antibodies & Assays for YES1 (Yes)

	Recombinant Proteins (Yes1)
	Antibodies (Yes1)

	Tagged/untagged cDNA clones
	Validated SYBR primer pairs
	Purified proteins from HEK293T cells
	Western blot validated antibodies
	shRNA in GFP-retroviral vector

Tocris compounds for YES1

Search www.enzolifesicences.com for proteins, assays, substrates, inhibitors & antibodies

Antibodies for YES1

GeneCards Homepage - Last full update: 2 Jul 2009 Incremental update: 13 Oct 2009

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YES1 Gene at Home site.
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YES1 Gene

protein-coding GIFtS: 69

Aliases &
Descriptions
for YES1

Summaries
for YES1

Genomic Location
for YES1

Proteins
for YES1

Protein Domains/
Families
for YES1

Gene Function
for YES1

Pathways & Interactions
for YES1

Drugs & Compounds
for YES1

Transcripts
for YES1

Expression
for YES1

Orthologs
for YES1

Paralogs
for YES1

SNPs/Variants
for YES1

Disorders & Mutations
for YES1

Medical News
for YES1

Publications
for YES1

Search for YES1

Genome Databases showing YES1

Other Databases showing YES1

Specialized Databases showing YES1

Licensable Technologies
for YES1

Services
for YES1

Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

YES1 Gene

protein-coding GIFtS: 69

Aliases & Descriptionsfor YES1

Summariesfor YES1

Genomic Locationfor YES1

Proteinsfor YES1

Protein Domains/Familiesfor YES1

Gene Functionfor YES1

Pathways & Interactionsfor YES1

Drugs & Compoundsfor YES1

Transcriptsfor YES1

Expression for YES1

Orthologsfor YES1

Paralogsfor YES1

SNPs/Variantsfor YES1

Disorders & Mutationsfor YES1

Medical Newsfor YES1

Publicationsfor YES1

Search for YES1

Genome Databases showing YES1

Other Databases showing YES1

Specialized Databases showing YES1

Licensable Technologiesfor YES1

Servicesfor YES1

Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

Aliases &
Descriptions
for YES1

Summaries
for YES1

Genomic Location
for YES1

Proteins
for YES1

Protein Domains/
Families
for YES1

Gene Function
for YES1

Pathways & Interactions
for YES1

Drugs & Compounds
for YES1

Transcripts
for YES1

Expression
for YES1

Orthologs
for YES1

Paralogs
for YES1

SNPs/Variants
for YES1

Disorders & Mutations
for YES1

Medical News
for YES1

Publications
for YES1

Licensable Technologies
for YES1

Services
for YES1