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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

YES1 Gene

protein-coding   GIFtS: 70
GCID: GC18M000721

v-yes-1 Yamaguchi sarcoma viral oncogene homolog 1

 Explore 22 diseases affiliated with
YES1 via our new
 Human Malady Compendium 
Biological research products
for YES1
    

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, and/or 10fRNAdb)
About This Section

Aliases
V-Yes-1 Yamaguchi Sarcoma Viral Oncogene Homolog 11 2     Cellular Yes-1 Protein2
HsT4411 2     Proto-Oncogene Tyrosine-Protein Kinase YES2
Yes1 2     Tyrosine-Protein Kinase Yes2
C-Yes1     Yamaguchi Sarcoma Oncogene2
Proto-Oncogene C-Yes2 3     YES3
EC 2.7.10.23 8     P61-Yes1
P61-YES2     EC 2.7.108

External Ids:    HGNC: 128411   Entrez Gene: 75252   Ensembl: ENSG000001761057   OMIM: 1648805   UniProtKB: P079473   

Export aliases for YES1 gene to outside databases

Previous GC identifers: GC22P022739 GC18M000709 GC18M000711


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for YES1:
This gene is the cellular homolog of the Yamaguchi sarcoma virus oncogene. The encoded protein has tyrosine kinase
activity and belongs to the src family of proteins. This gene lies in close proximity to thymidylate synthase gene on
chromosome 18, and a corresponding pseudogene has been found on chromosome 22. (provided by RefSeq, Jul 2008)

UniProtKB/Swiss-Prot: YES_HUMAN, P07947
Function: Non-receptor protein tyrosine kinase that is involved in the regulation of cell growth and survival,
apoptosis, cell-cell adhesion, cytoskeleton remodeling, and differentiation. Stimulation by receptor tyrosine kinases
(RTKs) including EGRF, PDGFR, CSF1R and FGFR leads to recruitment of YES1 to the phosphorylated receptor, and
activation and phosphorylation of downstream substrates. Upon EGFR activation, promotes the phosphorylation of PARD3
to favor epithelial tight junction assembly. Participates in the phosphorylation of specific junctional components
such as CTNND1 by stimulating the FYN and FER tyrosine kinases at cell-cell contacts. Upon T-cell stimulation by
CXCL12, phosphorylates collapsin response mediator protein 2/DPYSL2 and induces T-cell migration. Participates in
CD95L/FASLG signaling pathway and mediates AKT-mediated cell migration. Plays a role in cell cycle progression by
phosphorylating the cyclin-dependent kinase 4/CDK4 thus regulating the G1 phase. Also involved in G2/M progression and
cytokinesis

Gene Wiki entry for YES1


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000018.9  NC_018929.1  NT_010859.14  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the YES1 gene promoter:
         SRF   Pax-5   FOXO4   SRF (504 AA)   IRF-7A   NF-kappaB   NF-kappaB1   En-1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidYES1 promoter sequence
   Search SABiosciences Chromatin IP Primers for YES1

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat YES1


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 18p11.31-p11.21   Ensembl cytogenetic band:  18p11.32   HGNC cytogenetic band: 18p11.31-p11.21

YES1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
YES1 gene location

GeneLoc information about chromosome 18         GeneLoc Exon Structure

GeneLoc location for GC18M000721:  view genomic region     (about GC identifiers)

Start:
721,588 bp from pter      End:
812,547 bp from pter
Size:
90,960 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section

UniProtKB/Swiss-Prot: YES_HUMAN, P07947 (See protein sequence)
Recommended Name: Tyrosine-protein kinase Yes  
Size: 543 amino acids; 60801 Da
Subunit: Interacts with YAP1 and CSF1R (By similarity). Interacts with CTNND1; this interaction allows YES1-mediated
activation of FYN and FER and subsequent phosphorylation of CTNND1 (By similarity). Interacts with FASLG
Subcellular location: Cell membrane. Cytoplasm, cytoskeleton, centrosome. Cytoplasm, cytosol. Note=Newly synthesized
protein initially accumulates in the Golgi region and traffics to the plasma membrane through the exocytic pathway
1 PDB 3D structure from and Proteopedia for YES1:
2HDA (3D)    
Secondary accessions: A6NLB3 D3DUH1

Explore the universe of human proteins at neXtProt for YES1: NX_P07947

Post-translational modifications:

  • Phosphorylation by CSK on the C-terminal tail maintains the enzyme in an inactive state. Autophosphorylation at Tyr-426
  • maintains enzyme activity by blocking CSK-mediated inhibition1
  • Palmitoylation at Cys-3 promotes membrane localization (By similarity)1
  • View modification sites using PhosphoSitePlus2
  • View neXtProt modification sites for NX_P07947

  • 4/39 DME Specific Peptides for YES1 (P07947) (see all 39)
     DNGGYYI  DLSFKKG  LRHDKLV  KWTAPEA 

    YES1 Protein expression data from MOPED and PaxDb:    About this image 
    Estimated protein expression log10 (pmol).

    REFSEQ proteins: NP_005424.1  
    ENSEMBL proteins: 
     ENSP00000464380   ENSP00000462468   ENSP00000324740  
    Reactome Protein details: P07947
    Human Recombinant Protein Products: 
    EMD Millipore Purified and/or Recombinant YES1 Protein
    Browse R&D Systems for human recombinant proteins
    Browse recombinant and purified proteins available from Enzo Life Sciences
    OriGene Purified Protein: YES1
    OriGene Protein Over-expression Lysate: YES1
    OriGene Custom Protein Services for YES1 
    GenScript Custom Purified and Recombinant Proteins Services for YES1
    Novus Biologicals YES1 Proteins
    Novus Biologicals YES1 Lysates
    Browse Sino Biological Recombinant Proteins
    Browse ProSpec Recombinant Proteins
    Uscn Proteins for YES1

    Gene Ontology (GO): 5 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005737cytoplasm IDA--
    GO:0005794Golgi apparatus IDA--
    GO:0005815microtubule organizing center IEA--
    GO:0005829cytosol TAS--
    GO:0005886plasma membrane IDA--


    YES1 for ontologies           About GeneDecksing



    YES1 Antibody Products: 
    EMD Millipore Mono- and Polyclonal Antibodies for the study of YES1
    R&D Systems Antibodies for YES1 (Yes)
    Cell Signaling Technology (CST) Antibodies for YES1  (Yes)
    OriGene Antibodies (see all 2): YES1
    OriGene Custom Antibody Services for YES1 
    GenScript Custom Superior Antibodies Services for YES1
    Novus Biologicals YES1 Antibodies
    Abcam antibodies for YES1 
    Uscn Antibodies for YES1
    ThermoFisher Antibodies for YES1

    Assay Products for YES1: 
    Browse Kits and Assays available from EMD Millipore
    OriGene Custom Immunoassay Development
    Browse OriGene Fluorogenic Cell Assay Kits
    R&D Systems ELISAs for YES1 (Yes)         (see all)
    GenScript Custom Assay Services for YES1
    Browse Enzo Life Sciences for kits & assays
    Uscn ELISAs and CLIAs for YES1


    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section

    YES1 for domains           About GeneDecksing

    5/8 InterPro domains/families (see all 8):
     IPR017441 Protein_kinase_ATP_BS
     IPR001245 Ser-Thr/Tyr_kinase_cat_dom
     IPR011009 Kinase-like_dom
     IPR000980 SH2
     IPR001452 SH3_domain

    Graphical View of Domain Structure for InterPro Entry P07947

    ProtoNet protein and cluster: P07947

    3 Blocks protein families:
    IPB000980 SH2 domain signature
    IPB001452 SH3 domain signature
    IPB008266 Tyrosine protein kinase


    UniProtKB/Swiss-Prot: YES_HUMAN, P07947
    Similarity: Belongs to the protein kinase superfamily. Tyr protein kinase family. SRC subfamily
    Similarity: Contains 1 protein kinase domain
    Similarity: Contains 1 SH2 domain
    Similarity: Contains 1 SH3 domain


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
    About This Section

    Function Summary:

         UniProtKB/Swiss-Prot: YES_HUMAN, P07947
    Function: Non-receptor protein tyrosine kinase that is involved in the regulation of cell growth and survival,
    apoptosis, cell-cell adhesion, cytoskeleton remodeling, and differentiation. Stimulation by receptor tyrosine kinases
    (RTKs) including EGRF, PDGFR, CSF1R and FGFR leads to recruitment of YES1 to the phosphorylated receptor, and
    activation and phosphorylation of downstream substrates. Upon EGFR activation, promotes the phosphorylation of PARD3
    to favor epithelial tight junction assembly. Participates in the phosphorylation of specific junctional components
    such as CTNND1 by stimulating the FYN and FER tyrosine kinases at cell-cell contacts. Upon T-cell stimulation by
    CXCL12, phosphorylates collapsin response mediator protein 2/DPYSL2 and induces T-cell migration. Participates in
    CD95L/FASLG signaling pathway and mediates AKT-mediated cell migration. Plays a role in cell cycle progression by
    phosphorylating the cyclin-dependent kinase 4/CDK4 thus regulating the G1 phase. Also involved in G2/M progression and
    cytokinesis
    Catalytic activity: ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate

         Genatlas biochemistry entry for YES1:
    Yamaguchi sarcoma viral (v-yes-1) oncogene homolog 1

    Enzyme Numbers (IUBMB): EC 2.7.10.21 2 EC 2.7.102

    miRNA
    Products:
        
    miRTarBase miRNAs that target YES1:
    hsa-mir-145 (MIRT000627), hsa-mir-519a (MIRT005569), hsa-mir-17 (MIRT000263)

    OriGene 3'-UTR Clone: YES1
    Browse MicroRNA Expression Plasmids
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat YES1
    8/79 QIAGEN miScript miRNA Assays for microRNAs that regulate YES1 (see all 79):
    hsa-miR-140-5p hsa-miR-3678-3p hsa-miR-3194-5p hsa-miR-300 hsa-miR-106a hsa-miR-128 hsa-miR-519a hsa-miR-93
    SwitchGear 3'UTR luciferase reporter plasmidYES1 3' UTR sequence
    Inhib. RNA
    Products:
        
    Browse for Gene Knock-down Tools from EMD Millipore
    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for YES1 (see all 7)
    OriGene shRNA RFP: YES1
    OriGene siRNA: YES1
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat YES1

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for YES1

    Clone
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    Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
    OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for YES1 (see all 3)
    OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for YES1 (see all 2)
    OriGene custom cloning services – gene synthesis, subcloning, mutagenesis, variant library, vector shuttling 
    GenScript: all cDNA clones in your preferred vector: YES1 (NM_005433)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for YES1
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat YES1 

    Cell Line
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    GenScript Custom overexpressing Cell Line Services for YES1
    Search LifeMap BioReagents cell lines for YES1

    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for YES1

    Gene Ontology (GO): 5/7 molecular function terms (GO ID links to tree view) (see all 7):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004713protein tyrosine kinase activity TAS--
    GO:0004715non-membrane spanning protein tyrosine kinase activity TAS19267251
    GO:0005154epidermal growth factor receptor binding IEA--
    GO:0005515protein binding ----
    GO:0005524ATP binding IEA--


    YES1 for ontologies           About GeneDecksing


    4 GenomeRNAi human phenotypes for YES1:
     Decreased mitotic index  Decreased substrate adherent c  Decreased telomerase activity  Synthetic lethal with Ras 

    Animal Models:
         Mouse knock-out Yes1tm1Sor for YES1
         11 MGI mutant phenotypes (inferred from 2 alleles(MGI details for Yes1):
     growth/size  hematopoietic system  homeostasis/metabolism  immune system  integument 
     mortality/aging  nervous system  normal  renal/urinary system  respiratory system 
     skeleton 

    YES1 for phenotypes           About GeneDecksing


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
    About This Section

    Unified GeneCards pathways - 5/39 super-pathways (see all 39About this table 
    See pathways by source

    Super-pathwaycontained gene-specific pathways
    1Phosphorylation of GAB2 by SFKs
    Phosphorylation of GAB2 by SFKs1.00
    Regulation of KIT signaling0.44
    Phosphorylation of STATs0.47
    PECAM1 interactions0.38
    2Immune System
    Immune System1.00
    Innate Immune System0.46
    Adaptive Immune System0.59
    3CBL ubiquitinates PI3K
    CBL ubiquitinates PI3K1.00
    Regulation of signaling by CBL0.77
    4CD28 co-stimulation
    CD28 co-stimulation1.00
    Costimulation by the CD28 family0.41
    5Cleavage of Alpha-1-Microglobulin
    Sequestering and phosphorylation Fc gamma receptors in the lipid rafts0.66
    FCGR activation0.65

    Pathway sources
    See GeneCards unified pathways
    Show all pathways

    1 EMD Millipore Pathway for YES1
        Selected targets of Oct-3/4

    1 Downloadable PowerPoint Slide of QIAGEN Pathway Central Maps for YES1
        Epithelial Adherens Junctions

    2 Cell Signaling Technology (CST) Pathways for YES1
        MAP Kinase Signaling
    Tyrosine Kinases / Adaptors

    1 GeneGo (Thomson Reuters) Pathway for YES1
        CFTR-dependent regulation of ion channels in Airway Epithelium (norm and CF)

    5/18 BioSystems Pathways for YES1 (see all 18
        Interleukin-11 Signaling Pathway
    Kit Receptor Signaling Pathway
    Alpha6-Beta4 Integrin Signaling Pathway
    Signaling events mediated by PTP1B
    Signaling events mediated by focal adhesion kinase

    5/23        Reactome Pathways for YES1 (see all 23)
        Costimulation by the CD28 family
    FCGR activation
    Regulation of signaling by CBL
    CBL ubiquitinates PI3K
    Signaling by ERBB2


    2         Kegg Pathways  (Kegg details for YES1):
        Adherens junction
    Tight junction


    YES1 for pathways           About GeneDecksing

    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for YES1

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    5/281 Interacting proteins for YES1 (P079472, 3 ENSP000003247404) via UniProtKB, MINT, STRING, and/or I2D (see all 281)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    PDGFRBP096192, 3, ENSP000002617994MINT-8026872 MINT-8038029 I2D: score=3 STRING: ENSP00000261799
    MED28Q9H2042, 3, ENSP000002373804MINT-7041666 MINT-7041601 I2D: score=1 STRING: ENSP00000237380
    ADAM15Q134442, 3, ENSP000003494364MINT-2792392 I2D: score=2 STRING: ENSP00000349436
    PAK2Q131772, 3, ENSP000003140674MINT-2792076 I2D: score=2 STRING: ENSP00000314067
    PDCD6IPQ8WUM42, 3, ENSP000003073874MINT-68502 I2D: score=2 STRING: ENSP00000307387
    About this table

    Gene Ontology (GO): 5/7 biological process terms (GO ID links to tree view) (see all 7):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006464cellular protein modification process TAS2436037
    GO:0007596blood coagulation TAS--
    GO:0015758glucose transport IEA--
    GO:0031295T cell costimulation TAS--
    GO:0043114regulation of vascular permeability TAS19267251


    YES1 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section

    YES1 for compounds           About GeneDecksing

    Browse Small Molecules at EMD Millipore
    Enzo Life Sciences drugs & compounds for YES1

    Browse Tocris compounds for YES1

    2 HMDB Compounds for YES1    About this table
    CompoundSynonyms CAS #PubMed Ids
    ADPadenosindiphosphorsaeure (see all 8)58-64-0--
    Adenosine triphosphate5'-(tetrahydrogen triphosphate) Adenosine (see all 24)56-65-5--

    1 DrugBank Compound for YES1    About this table
    CompoundSynonyms CAS #TypeActionsPubMed Ids
    Dasatinib-- 302962-49-8targetinhibitor17541990 16507911 20072833

    5 Novoseek chemical compound relationships for YES1 gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    tyrosine 61.8 27 8246968 (4), 7690926 (2), 7478608 (2), 7690925 (2) (see all 17)
    phosphotyrosine 46.7 1 8246968 (1)
    thymidylate 36.3 2 8449516 (1), 15548681 (1)
    serine 26.7 2 8035999 (1), 8813150 (1)
    threonine 13.3 1 8813150 (1)

    Search CenterWatch for drugs/clinical trials and news about YES1 / YES 

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for YES1 gene: 
    NM_005433.3  

    Unigene Cluster for YES1:

    V-yes-1 Yamaguchi sarcoma viral oncogene homolog 1
    Hs.194148  [show with all ESTs]
    Unigene Representative Sequence: NM_005433
    5 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000577961(uc002kky.3) ENST00000584307(uc002kkz.3) ENST00000314574
    ENST00000577611 ENST00000581960

    miRNA
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    OriGene 3'-UTR Clone: YES1
    Browse OriGene MicroRNA Expression Plasmids
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat YES1
    8/79 QIAGEN miScript miRNA Assays for microRNAs that regulate YES1 (see all 79):
    hsa-miR-140-5p hsa-miR-3678-3p hsa-miR-3194-5p hsa-miR-300 hsa-miR-106a hsa-miR-128 hsa-miR-519a hsa-miR-93
    SwitchGear 3'UTR luciferase reporter plasmidYES1 3' UTR sequence
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    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for YES1 (see all 7)
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    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat YES1
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    GenScript: all cDNA clones in your preferred vector: YES1 (NM_005433)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for YES1
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    Primer
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    Browse OriGene validated miRNA SYBR primer pairs
    SABiosciences RT2 qPCR Primer Assay in human, mouse, rat YES1
      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat YES1
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat YES1

    Additional cDNA sequence: 

    AK314063.1 BC031080.1 BC048960.1 M15990.1 

    11 DOTS entries:

    DT.95156689  DT.416485  DT.95356709  DT.121087601  DT.100647936  DT.70105092  DT.121087580  DT.100785653 
    DT.100785654  DT.121087582  DT.91658947 

    24/174 AceView cDNA sequences (see all 174):

    N53374 NM_005433 BF438787 T28838 AI124049 AA126692 CB410797 BP360000 
    CB145677 BU753250 AA843100 AA345032 BG289848 BM837753 AL047403 BU753688 
    BG026275 AA130041 BI496989 BX110440 AL121509 AI873533 CA397481 AU116847 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    YES1 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS
    CGAP TAG: AGATTTTTTA

    Microarray
    RNAseq (Illumina Body Map)
    (100×FPKM)½
    SAGE (Serial Analysis of Gene Expression)

    About this image
    See YES1 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for YES1

    SOURCE GeneReport for Unigene cluster: Hs.194148

    UniProtKB/Swiss-Prot: YES_HUMAN, P07947
    Tissue specificity: Expressed in the epithelial cells of renal proximal tubules and stomach as well as hematopoietic
    cells in the bone marrow and spleen in the fetal tissues. In adult, expressed in epithelial cells of the renal
    proximal tubules and present in keratinocytes in the basal epidermal layer of epidermis

        SABiosciences Custom PCR Arrays for YES1
    Primer
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    QIAGEN QuantiFast Probe-based Assays in human, mouse, rat YES1
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for YES1

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of animals.

    Orthologs for YES1 gene from 6/21 species (see all 21)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    chicken
    (Gallus gallus)
    Aves YES11 v-yes-1 Yamaguchi sarcoma viral oncogene homolog 1 84.47(n)
    92.24(a)
      396238  NM_205301.1  NP_990632.1 
    lizard
    (Anolis carolinensis)
    Reptilia YES16
    --
    91(a)
    1 ↔ 1
    4(39553339-39568329)
    African clawed frog
    (Xenopus laevis)
    Amphibia MGC684442 hypothetical protein MGC68444 81.27(n)    BC049390.1 
    zebrafish
    (Danio rerio)
    Actinopterygii yes11 v-yes-1 Yamaguchi sarcoma viral oncogene homolog 1 72.44(n)
    86.37(a)
      407620  NM_001013270.2  NP_001013288.2 
    fruit fly
    (Drosophila melanogaster)
    Insecta Src64B3 ring canal formation protein tyrosine kinase 51(a)   64B12   --
    worm
    (Caenorhabditis elegans)
    Secernentea src-13 Expression: vulva, anus, mu_bod, pharyngeal
    muscle, more
    49(a)
    (best of 4)
      I(1567610-1580076)   --


    ENSEMBL Gene Tree for YES1 (if available)
    TreeFam Gene Tree for YES1 (if available) 

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for YES1 gene
    TEC2  FRK2  LCK2  BLK2  FGR2  ITK2  LYN2  TXK2  
    HCK2  PTK62  SRC2  ABL12  FYN2  BMX2  ABL22  SRMS2  
    BTK2  
    18/53 SIMAP similar genes for YES1 using alignment to 3 protein entries:     YES_HUMAN (see all proteins) (see all similar genes):
    SRC    LYN    BLK    HCK    FYN    ABL1
    FGR    FRK    LCK    NCK2    EPHA2    GRAPL
    ARHGEF7    BCR/ABL fusion    BTK kinase deficient isoform 6    EPHA6    GRAP2    GRB2

    YES1 for paralogs           About GeneDecksing


    1 Pseudogenes.org Pseudogene for YES1
    PGOHUM00000246552


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/1699 NCBI SNPs in YES1 are shown (see all 1699    About this table
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 18 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1486649111,2
    --721149(+) CACTC-/AAAATT 1 -- ds50010--------
    rs65064741,2
    C,F,A,H,--721198(+) TTTAAA/GAAGAA 1 -- ds500126Minor allele frequency- G:0.36NS EA NA WA CSA 2484
    rs1134383181,2
    C,--721280(+) CGCCTG/CTAATC 1 -- ds50011Minor allele frequency- C:0.50WA 2
    rs1434698051,2
    --721311(+) AGCGGA/GCGGAT 1 -- ds50010--------
    rs1901026861,2
    --721313(+) CGGACA/GGATCA 1 -- ds50010--------
    rs1412184261,2
    --721373(+) TCTACG/TAAAAA 1 -- ds50010--------
    rs65064751,2
    C,A,--721459(+) CGTGAA/CCCCGG 1 -- ds50015Minor allele frequency- C:0.00NA WA CSA 9
    rs764198171,2
    C,--721487(+) GAGCCA/GAGATC 1 -- ds50010--------
    rs80983801,2
    C,F,A,--721563(+) CAAAAC/AAAAAA 1 -- ds50014Minor allele frequency- A:0.25NA WA CSA 8
    rs1826847581,2
    --721611(+) GAATTG/TAATAA 1 -- ut310--------

    HapMap Linkage Disequilibrium report for YES1 (721588 - 812547 bp)
    Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
    Database of Genomic Variants (DGV): 1 variation for YES1
         1 CNV: 5044

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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section

    YES1 for disorders           About GeneDecksing

    OMIM gene information: 164880    OMIM disorders: --

    20/22 diseases for YES1 (see all 22):    About MalaCards
    sarcoma    patellofemoral pain syndrome    non-small cell lung carcinoma    squamous cell carcinoma of the head and neck
    squamous cell carcinoma    inflammatory bowel disease    familial pancreatic cancer    paine syndrome
    colon carcinoma    colon cancer    lung carcinoma    pancreatic cancer
    carcinoma    skin cancer    melanoma    hepatocellular carcinoma
    pancreatitis    gastric cancer    pharyngitis    breast cancer

    7 Novoseek disease relationships for YES1 gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    colon cancer 31.4 2 8674385 (1), 9690379 (1)
    mammary tumor 30.9 4 10027159 (2), 7478608 (1)
    colon carcinoma 27.6 2 7690925 (2)
    cancer 17.3 4 17143518 (2), 17898870 (1)
    carcinoma 15.1 1 7690925 (1)
    tumors 1.99 7 10027159 (3), 8674385 (1), 17898870 (1), 17143518 (1) (see all 5)
    melanoma 0 7 9681823 (3), 7690926 (3)

    Human Genome Epidemiology (HuGE) Navigator: YES1 (3 documents)
    Tumor Gene Database (TGDB): YES1

    Export disorders for YES1 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for YES1 gene, integrated from 9 sources (see all 146):
    (articles sorted by number of sources associating them with YES1)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. CD46 is phosphorylated at tyrosine 354 upon infection of epithelial cells by Neisseria gonorrhoeae. (PubMed id 11901164)1, 2, 9 Lee S.W....So M. (2002)
    2. Differential trafficking of Src, Lyn, Yes and Fyn is specified by the state of palmitoylation in the SH4 domain. (PubMed id 19258394)1, 2 Sato I....Yamaguchi N. (2009)
    3. Identification of SH3 domain interaction partners of human FasL (CD178) by phage display screening. (PubMed id 19807924)1, 2 Voss M....Janssen O. (2009)
    4. Crystallographic structure of the SH3 domain of the human c-Yes tyrosine kinase: loop flexibility and amyloid aggregation. (PubMed id 17418139)1, 2 Martin-Garcia J.M....Camara-Artigas A. (2007)
    5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    6. Autophosphorylation of Src and Yes blocks their inactivation by Csk phosphorylation. (PubMed id 9794236)1, 2 Sun G....Budde R.J. (1998)
    7. Differential expression of p62c-yes in normal, hyperplastic and neoplastic human epidermis. (PubMed id 2067846)1, 2 Krueger J....Sudol M. (1991)
    8. Characterization of cDNA clones for the human c-yes gene. (PubMed id 2436037)1, 2 Sukegawa J.... Toyoshima K. (1987)
    9. Location of the c-yes gene on the human chromosome and its expression in various tissues. (PubMed id 2983418)1, 3 Semba K....Toyoshima K. (1985)
    10. Identification of c-Yes expression in the nuclei of hepatocellular carcinoma cells: involvement in the early stages of hepatocarcinogenesis. (PubMed id 17143518)1, 9 Nonomura T....Kuriyama S. (2007)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 7525 HGNC: 12841 AceView: YES1 Ensembl:ENSG00000176105 euGenes: HUgn7525
    ECgene: YES1 Kegg: 7525 H-InvDB: YES1

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for YES1 Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for YES1 Genetics and Cytogenetics in Oncology and Haematology

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for YES1 gene:
    Search GeneIP for patents involving YES1

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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    About This Section

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    GeneCards Homepage - Last full update: 19 Mar 2013 - Incrementals: 21 Mar 2013 , 15 Apr 2013 , 26 Apr 2013

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