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YES1 Gene

protein-coding   GIFtS: 74
GCID: GC18M000721

V-Yes-1 Yamaguchi Sarcoma Viral Oncogene Homolog 1

  See YES1-related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
V-Yes-1 Yamaguchi Sarcoma Viral Oncogene Homolog 11 2     Cellular Yes-1 Protein2
Proto-Oncogene C-Yes2 3     Proto-Oncogene Tyrosine-Protein Kinase YES2
EC 2.7.10.23 8     Tyrosine-Protein Kinase Yes2
HsT4412     Yamaguchi Sarcoma Oncogene2
P61-YES2     YES3
Yes2     p61-Yes3
c-yes2     EC 2.7.108

External Ids:    HGNC: 128411   Entrez Gene: 75252   Ensembl: ENSG000001761057   OMIM: 1648805   UniProtKB: P079473   

Export aliases for YES1 gene to outside databases

Previous GC identifers: GC22P022739 GC18M000709 GC18M000711


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for YES1 Gene:
This gene is the cellular homolog of the Yamaguchi sarcoma virus oncogene. The encoded protein has tyrosine kinase
activity and belongs to the src family of proteins. This gene lies in close proximity to thymidylate synthase
gene on chromosome 18, and a corresponding pseudogene has been found on chromosome 22. (provided by RefSeq, Jul
2008)

GeneCards Summary for YES1 Gene:
YES1 (v-yes-1 Yamaguchi sarcoma viral oncogene homolog 1) is a protein-coding gene. Diseases associated with YES1 include megaesophagus, and sarcoma. GO annotations related to this gene include ion channel binding and enzyme binding. An important paralog of this gene is FRK.

UniProtKB/Swiss-Prot: YES_HUMAN, P07947
Function: Non-receptor protein tyrosine kinase that is involved in the regulation of cell growth and survival,
apoptosis, cell-cell adhesion, cytoskeleton remodeling, and differentiation. Stimulation by receptor tyrosine
kinases (RTKs) including EGRF, PDGFR, CSF1R and FGFR leads to recruitment of YES1 to the phosphorylated receptor,
and activation and phosphorylation of downstream substrates. Upon EGFR activation, promotes the phosphorylation
of PARD3 to favor epithelial tight junction assembly. Participates in the phosphorylation of specific junctional
components such as CTNND1 by stimulating the FYN and FER tyrosine kinases at cell-cell contacts. Upon T-cell
stimulation by CXCL12, phosphorylates collapsin response mediator protein 2/DPYSL2 and induces T-cell migration.
Participates in CD95L/FASLG signaling pathway and mediates AKT-mediated cell migration. Plays a role in cell
cycle progression by phosphorylating the cyclin-dependent kinase 4/CDK4 thus regulating the G1 phase. Also
involved in G2/M progression and cytokinesis

Gene Wiki entry for YES1 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence:
NC_000018.10  NT_010859.15  NC_018929.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the YES1 gene promoter:
         SRF   Pax-5   FOXO4   SRF (504 AA)   IRF-7A   NF-kappaB   NF-kappaB1   En-1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidYES1 promoter sequence
   Search Chromatin IP Primers for YES1

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat YES1


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 18p11.31-p11.21   Ensembl cytogenetic band:  18p11.32   HGNC cytogenetic band: 18p11.31-p11.21

YES1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
YES1 gene location

GeneLoc information about chromosome 18         GeneLoc Exon Structure

GeneLoc location for GC18M000721:  view genomic region     (about GC identifiers)

Start:
721,588 bp from pter      End:
812,547 bp from pter
Size:
90,960 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., and/or eBioscience,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., and/or eBioscience, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: YES_HUMAN, P07947 (See protein sequence)
Recommended Name: Tyrosine-protein kinase Yes  
Size: 543 amino acids; 60801 Da
Subunit: Interacts with YAP1 and CSF1R (By similarity). Interacts with CTNND1; this interaction allows
YES1-mediated activation of FYN and FER and subsequent phosphorylation of CTNND1 (By similarity). Interacts with
FASLG
1 PDB 3D structure from and Proteopedia for YES1:
2HDA (3D)    
Secondary accessions: A6NLB3 D3DUH1

Explore the universe of human proteins at neXtProt for YES1: NX_P07947

Explore proteomics data for YES1 at MOPED

Post-translational modifications: 

  • Phosphorylation by CSK on the C-terminal tail maintains the enzyme in an inactive state. Autophosphorylation at
    Tyr-426 maintains enzyme activity by blocking CSK-mediated inhibition1
  • Palmitoylation at Cys-3 promotes membrane localization (By similarity)1
  • Ubiquitination2 at Lys191, Lys235, Lys437
  • Modification sites at PhosphoSitePlus
  • Selected DME Specific Peptides for YES1 (P07947) (see all 39)
     DNGGYYI  DLSFKKG  LRHDKLV  KWTAPEA 


    See YES1 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_005424.1  
    ENSEMBL proteins: 
     ENSP00000464380   ENSP00000462468   ENSP00000324740  
    Reactome Protein details: P07947

    YES1 Human Recombinant Protein Products:

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    Novus Biologicals YES1 Proteins
    Novus Biologicals YES1 Lysates
    Sino Biological Recombinant Protein for YES1
    Sino Biological Cell Lysate for YES1
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for YES1

     
    Search eBioscience for Proteins for YES1 

    YES1 Antibody Products:

    EMD Millipore Mono- and Polyclonal Antibodies for the study of YES1
    R&D Systems Antibodies for YES1 (Yes)
    Cell Signaling Technology (CST) Antibodies for YES1  (Yes)
    OriGene Antibodies for YES1
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    Novus Biologicals YES1 Antibodies
    Abcam antibodies for YES1
    Cloud-Clone Corp. Antibodies for YES1
    ThermoFisher Antibody for YES1
    LSBio Antibodies in human, mouse, rat for YES1

    YES1 Assay Products:

    Browse Kits and Assays available from EMD Millipore
    OriGene Custom Assay Services for YES1
    R&D Systems ELISAs for YES1 (Yes)         (see all)
    GenScript Custom Assay Services for YES1
    Browse Enzo Life Sciences for kits & assays
    Cloud-Clone Corp. ELISAs for YES1
    Cloud-Clone Corp. CLIAs for YES1
    Search eBioscience for ELISAs for YES1 


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    SH2D: SH2 domain containing

    IUPHAR Guide to PHARMACOLOGY protein family classification: v-yes-1 Yamaguchi sarcoma viral oncogene homolog 1
    Src family

    Selected InterPro protein domains (see all 8):
     IPR017441 Protein_kinase_ATP_BS
     IPR011009 Kinase-like_dom
     IPR001452 SH3_domain
     IPR000719 Prot_kinase_dom
     IPR001245 Ser-Thr/Tyr_kinase_cat_dom

    Graphical View of Domain Structure for InterPro Entry P07947

    ProtoNet protein and cluster: P07947

    3 Blocks protein domains:
    IPB000980 SH2 domain signature
    IPB001452 SH3 domain signature
    IPB008266 Tyrosine protein kinase


    UniProtKB/Swiss-Prot: YES_HUMAN, P07947
    Similarity: Belongs to the protein kinase superfamily. Tyr protein kinase family. SRC subfamily
    Similarity: Contains 1 protein kinase domain
    Similarity: Contains 1 SH2 domain
    Similarity: Contains 1 SH3 domain


    Find genes that share domains with YES1           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: YES_HUMAN, P07947
    Function: Non-receptor protein tyrosine kinase that is involved in the regulation of cell growth and survival,
    apoptosis, cell-cell adhesion, cytoskeleton remodeling, and differentiation. Stimulation by receptor tyrosine
    kinases (RTKs) including EGRF, PDGFR, CSF1R and FGFR leads to recruitment of YES1 to the phosphorylated receptor,
    and activation and phosphorylation of downstream substrates. Upon EGFR activation, promotes the phosphorylation
    of PARD3 to favor epithelial tight junction assembly. Participates in the phosphorylation of specific junctional
    components such as CTNND1 by stimulating the FYN and FER tyrosine kinases at cell-cell contacts. Upon T-cell
    stimulation by CXCL12, phosphorylates collapsin response mediator protein 2/DPYSL2 and induces T-cell migration.
    Participates in CD95L/FASLG signaling pathway and mediates AKT-mediated cell migration. Plays a role in cell
    cycle progression by phosphorylating the cyclin-dependent kinase 4/CDK4 thus regulating the G1 phase. Also
    involved in G2/M progression and cytokinesis
    Catalytic activity: ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate

         Genatlas biochemistry entry for YES1:
    Yamaguchi sarcoma viral (v-yes-1) oncogene homolog 1

         Enzyme Numbers (IUBMB): EC 2.7.10.21 2 EC 2.7.102

         Gene Ontology (GO): Selected molecular function terms (see all 9):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004672protein kinase activity ----
    GO:0004713protein tyrosine kinase activity TAS--
    GO:0004715non-membrane spanning protein tyrosine kinase activity TAS19267251
    GO:0005154epidermal growth factor receptor binding IEA--
    GO:0005515protein binding IPI15657067
         
    Find genes that share ontologies with YES1           About GenesLikeMe


    Phenotypes:
         4 GenomeRNAi human phenotypes for YES1:
     Decreased mitotic index  Decreased substrate adherent c  Decreased telomerase activity  Synthetic lethal with Ras 

         11 MGI mutant phenotypes (inferred from 2 alleles(MGI details for Yes1):
     growth/size/body  hematopoietic system  homeostasis/metabolism  immune system  integument 
     mortality/aging  nervous system  normal  renal/urinary system  respiratory system 
     skeleton 

    Find genes that share phenotypes with YES1           About GenesLikeMe

    Animal Models:
         MGI mouse knock-out Yes1tm1Sor for YES1

       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for YES1
       inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for YES1

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for YES1
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for YES1

    miRNA
    Products:
        
    miRTarBase miRNAs that target YES1:
    hsa-mir-106b-5p (MIRT044267), hsa-mir-125a-5p (MIRT021309), hsa-mir-519a-3p (MIRT005569), hsa-mir-17-5p (MIRT000263), hsa-mir-145-5p (MIRT000627), hsa-mir-142-3p (MIRT021620), hsa-mir-205-5p (MIRT024970), hsa-mir-186-5p (MIRT021096), hsa-mir-10a-5p (MIRT025605)

    Block miRNA regulation of human, mouse, rat YES1 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate YES1 (see all 79):
    hsa-miR-140-5p hsa-miR-3678-3p hsa-miR-3194-5p hsa-miR-300 hsa-miR-106a hsa-miR-128 hsa-miR-519a hsa-miR-93
    SwitchGear 3'UTR luciferase reporter plasmidYES1 3' UTR sequence
    Inhib. RNA
    Products:
        
    OriGene RNAi products in human, mouse, rat for YES1
    Predesigned siRNA for gene silencing in human, mouse, rat YES1

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for YES1

    Clone
    Products:
         
    OriGene clones in human, mouse for YES1 (see all 7)
    OriGene ORF clones in mouse, rat for YES1
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: YES1 (NM_005433)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for YES1
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat YES1
    Addgene plasmids for YES1 

    Cell Line
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    GenScript Custom overexpressing Cell Line Services for YES1
    Browse ESI BIO Cell Lines and PureStem Progenitors for YES1 
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for YES1


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    YES_HUMAN, P07947: Cell membrane. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome.
    Cytoplasm, cytosol. Note=Newly synthesized protein initially accumulates in the Golgi region and traffics to the
    plasma membrane through the exocytic pathway
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    cytoskeleton5
    cytosol5
    golgi apparatus5
    plasma membrane5
    mitochondrion1
    nucleus1

    Gene Ontology (GO): Selected cellular component terms (see all 6):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005737cytoplasm IDA--
    GO:0005794Golgi apparatus IDA--
    GO:0005815microtubule organizing center IEA--
    GO:0005829cytosol TAS--
    GO:0005886plasma membrane IDA--

    Find genes that share ontologies with YES1           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for YES1 About   (see all 37)  
    See pathways by source

    SuperPathContained pathways About
    1Signaling by Interleukins
    Interleukin-3, 5 and GM-CSF signaling0.59
    Regulation of signaling by CBL0.00
    Signaling by Interleukins0.42
    2CD28 co-stimulation
    CD28 co-stimulation0.66
    CTLA4 inhibitory signaling0.32
    Costimulation by the CD28 family0.44
    3PI-3K cascade
    Signaling by SCF-KIT0.72
    Regulation of KIT signaling0.00
    4Cell surface interactions at the vascular wall
    Cell surface interactions at the vascular wall
    PECAM1 interactions0.00
    5Signaling by FGFR
    Signaling by ERBB20.89


    Find genes that share SuperPaths with YES1           About GenesLikeMe

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    1 R&D Systems Pathway for YES1
        VEGF - VEGF R2 Signaling Pathways

    1 Downloadable PowerPoint Slide of GeneGlobe Pathway Central Maps for YES1
        Epithelial Adherens Junctions

    2 Cell Signaling Technology (CST) Pathways for YES1
        MAP Kinase Signaling
    Tyrosine Kinases / Adaptors

    1 GeneGo (Thomson Reuters) Pathway for YES1
        CFTR-dependent regulation of ion channels in Airway Epithelium (norm and CF)

    Selected BioSystems Pathways for YES1 (see all 18)
        Alpha6-Beta4 Integrin Signaling Pathway
    Kit Receptor Signaling Pathway
    Interleukin-11 Signaling Pathway
    Signaling events mediated by VEGFR1 and VEGFR2
    Glypican 1 network


    Selected Reactome Pathways for YES1 (see all 8)
        FCGR activation
    Regulation of signaling by CBL
    PECAM1 interactions
    Signaling by ERBB2
    Regulation of KIT signaling


    2 Kegg Pathways  (Kegg details for YES1):
        Adherens junction
    Tight junction

        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for YES1
    Interactions:

        GeneGlobe Interaction Network for YES1

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for YES1 (P079471, 2, 3 ENSP000003247404) via UniProtKB, MINT, STRING, and/or I2D (see all 331)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    MED28Q9H2041, 2, 3, ENSP000002373804EBI-515331,EBI-514199 MINT-7041666 MINT-7041601 I2D: score=1 STRING: ENSP00000237380
    PDCD6IPQ8WUM42, 3, ENSP000003073874MINT-68502 I2D: score=2 STRING: ENSP00000307387
    ABI1Q8IZP02, 3, ENSP000003653124MINT-7908091 I2D: score=1 STRING: ENSP00000365312
    SPRR2AP353262, 3, ENSP000003764234MINT-7303771 I2D: score=1 STRING: ENSP00000376423
    ITGB3P051062, 3MINT-7384460 I2D: score=2 
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 11):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006464cellular protein modification process TAS2436037
    GO:0006468protein phosphorylation ----
    GO:0007596blood coagulation TAS--
    GO:0015758glucose transport IEA--
    GO:0018108peptidyl-tyrosine phosphorylation TAS19267251

    Find genes that share ontologies with YES1           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Enzo Life Sciences drugs & compounds for YES1
      Browse compounds at ApexBio 

    Browse Tocris compounds for YES1 (YES)

    2 HMDB Compounds for YES1    About this table
    CompoundSynonyms CAS #PubMed Ids
    ADPadenosindiphosphorsaeure (see all 8)58-64-0--
    Adenosine triphosphate5'-(tetrahydrogen triphosphate) Adenosine (see all 24)56-65-5--

    1 DrugBank Compound for YES1    About this table
    CompoundSynonyms CAS #TypeActionsPubMed Ids
    Dasatinib-- 302962-49-8targetinhibitor17541990 16507911 20072833

    5 Novoseek inferred chemical compound relationships for YES1 gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    tyrosine 61.8 27 8246968 (4), 7690926 (2), 7478608 (2), 7690925 (2) (see all 17)
    phosphotyrosine 46.7 1 8246968 (1)
    thymidylate 36.3 2 8449516 (1), 15548681 (1)
    serine 26.7 2 8035999 (1), 8813150 (1)
    threonine 13.3 1 8813150 (1)



    Find genes that share compounds with YES1           About GenesLikeMe



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for YES1 gene: 
    NM_005433.3  

    Unigene Cluster for YES1:

    V-yes-1 Yamaguchi sarcoma viral oncogene homolog 1
    Hs.194148  [show with all ESTs]
    Unigene Representative Sequence: NM_005433
    5 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000577961(uc002kky.3) ENST00000584307(uc002kkz.3) ENST00000314574
    ENST00000577611 ENST00000581960
    miRNA
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    Block miRNA regulation of human, mouse, rat YES1 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate YES1 (see all 79):
    hsa-miR-140-5p hsa-miR-3678-3p hsa-miR-3194-5p hsa-miR-300 hsa-miR-106a hsa-miR-128 hsa-miR-519a hsa-miR-93
    SwitchGear 3'UTR luciferase reporter plasmidYES1 3' UTR sequence
    Inhib. RNA
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    Clone
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    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: YES1 (NM_005433)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for YES1
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat YES1
    Addgene plasmids for YES1 
    Primer
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    OriGene qPCR primer pairs and template standards for YES1
    OriGene qSTAR qPCR primer pairs in human, mouse for YES1
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat YES1
      QuantiTect SYBR Green Assays in human, mouse, rat YES1
      QuantiFast Probe-based Assays in human, mouse, rat YES1

    Additional mRNA sequence: 

    AK314063.1 BC031080.1 BC048960.1 M15990.1 

    11 DOTS entries:

    DT.95156689  DT.416485  DT.95356709  DT.121087601  DT.100647936  DT.70105092  DT.121087580  DT.100785653 
    DT.100785654  DT.121087582  DT.91658947 

    Selected AceView cDNA sequences (see all 174):

    AA345032 AA843100 N53374 NM_005433 CB145677 BP360000 BG289848 AL047403 
    AA126692 BF438787 CB410797 BU753250 T28838 AI124049 BM837753 BM990753 
    BX110440 BP336884 BP379820 BM969640 BG165530 AU123956 BU753688 BF793664 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

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    YES1 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: AGATTTTTTA
    YES1 Expression
    About this image


    YES1 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     
     Blood (Hematopoietic System)    fully expand to see all 3 entries
             Hematopoietic Stem Cells Hematopoietic Bone Marrow
             Peripheral blood-derived hematopoietic stem cells (family)
    YES1 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    YES1 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.194148

    UniProtKB/Swiss-Prot: YES_HUMAN, P07947
    Tissue specificity: Expressed in the epithelial cells of renal proximal tubules and stomach as well as
    hematopoietic cells in the bone marrow and spleen in the fetal tissues. In adult, expressed in epithelial cells
    of the renal proximal tubules and present in keratinocytes in the basal epidermal layer of epidermis

        Custom PCR Arrays for YES1
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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of chordates.

    Orthologs for YES1 gene from Selected species (see all 15)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Yes11 , 5 Yamaguchi sarcoma viral (v-yes) oncogene homolog 11, 5 91.37(n)1
    96.3(a)1
      5 (17.33 cM)5
    226121  NM_001205133.11  NP_001192062.11 
     326111715 
    chicken
    (Gallus gallus)
    Aves YES11 v-yes-1 Yamaguchi sarcoma viral oncogene homolog 1 84.47(n)
    92.24(a)
      396238  NM_205301.1  NP_990632.1 
    lizard
    (Anolis carolinensis)
    Reptilia YES16
    v-yes-1 Yamaguchi sarcoma viral oncogene homolog 1...
    89(a)
    1 ↔ 1
    4(39553339-39618391)
    African clawed frog
    (Xenopus laevis)
    Amphibia MGC684442 hypothetical protein MGC68444 81.27(n)    BC049390.1 
    zebrafish
    (Danio rerio)
    Actinopterygii yes11 v-yes-1 Yamaguchi sarcoma viral oncogene homolog 1 72.31(n)
    86.37(a)
      407620  NM_001013270.3  NP_001013288.2 


    ENSEMBL Gene Tree for YES1 (if available)
    TreeFam Gene Tree for YES1 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for YES1 gene
    FRK2  LCK2  BLK2  LYN2  FGR2  PTK62  HCK2  ABL12  
    SRC2  FYN2  ABL22  SRMS2  
    Selected SIMAP similar genes for YES1 using alignment to 3 protein entries:     YES_HUMAN (see all proteins) (see all similar genes):
    SRC    LYN    BLK    HCK    FYN    ABL1
    FGR    FRK    LCK    NCK2    EPHA2    GRAPL
    ARHGEF7    BCR/ABL fusion    BTK kinase deficient isoform 6    EPHA6    GRAP2    GRB2

    Find genes that share paralogs with YES1           About GenesLikeMe


    1 Pseudogenes.org Pseudogene for YES1
    PGOHUM00000246552


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for YES1 (see all 2027)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 18 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1486649111,2
    C--713050(+) CACTC-/AAAATT 1 -- ds50010--------
    rs65064741,2
    C,F,A,H--713099(+) TTTAAA/GAAGAA 1 -- ds500126Minor allele frequency- G:0.36NS EA NA WA CSA 2484
    rs1134383181,2
    C,F--713181(+) CGCCTG/CTAATC 1 -- ds50011Minor allele frequency- C:0.50WA 2
    rs1434698051,2
    --713212(+) AGCGGA/GCGGAT 1 -- ds50010--------
    rs1901026861,2
    --713214(+) CGGACA/GGATCA 1 -- ds50010--------
    rs1412184261,2
    C--713274(+) TCTACG/TAAAAA 1 -- ds50010--------
    rs65064751,2
    C,A--713360(+) CGTGAA/CCCCGG 1 -- ds50015Minor allele frequency- C:0.00NA WA CSA 9
    rs764198171,2
    C--713388(+) GAGCCA/GAGATC 1 -- ds50010--------
    rs80983801,2
    C,F,A--713464(+) CAAAAC/AAAAAA 1 -- ds50014Minor allele frequency- A:0.25NA WA CSA 8
    rs1826847581,2
    --713512(+) GAATTG/TAATAA 1 -- ut310--------

    HapMap Linkage Disequilibrium report for YES1 (721588 - 812547 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 5 variations for YES1:    About this table    
    Variant IDTypeSubtypePubMed ID
    nsv909289CNV Loss21882294
    nsv528169CNV Loss19592680
    nsv909288CNV Loss21882294
    nsv833577CNV Gain+Loss17160897
    esv1006381OTHER Inversion20482838

    Site Specific Mutation Identification with PCR Assays
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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 164880    OMIM disorders: --

    2 diseases for YES1:    
    About MalaCards
    megaesophagus    sarcoma


    Find genes that share disorders with YES1           About GenesLikeMe

    7 Novoseek inferred disease relationships for YES1 gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    colon cancer 31.4 2 8674385 (1), 9690379 (1)
    mammary tumor 30.9 4 10027159 (2), 7478608 (1)
    colon carcinoma 27.6 2 7690925 (2)
    cancer 17.3 4 17143518 (2), 17898870 (1)
    carcinoma 15.1 1 7690925 (1)
    tumors 1.99 7 10027159 (3), 8674385 (1), 17898870 (1), 17143518 (1) (see all 5)
    melanoma 0 7 9681823 (3), 7690926 (3)

    Genetic Association Database (GAD): YES1
    Human Genome Epidemiology (HuGE) Navigator: YES1 (3 documents)
    Tumor Gene Database (TGDB): YES1

    Export disorders for YES1 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for YES1 gene, integrated from 10 sources (see all 165):
    (articles sorted by number of sources associating them with YES1)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. CD46 is phosphorylated at tyrosine 354 upon infection of epithelial cells by Neisseria gonorrhoeae. (PubMed id 11901164)1, 2, 9 Lee S.W....So M. (J. Cell Biol. 2002)
    2. Polymorphisms in innate immunity genes and patients response to dendritic cell-based HIV immuno-treatment. (PubMed id 20056178)1, 4 Segat L....Crovella S. (Vaccine 2010)
    3. Differential trafficking of Src, Lyn, Yes and Fyn is specified by the state of palmitoylation in the SH4 domain. (PubMed id 19258394)1, 2 Sato I.... Yamaguchi N. (J. Cell Sci. 2009)
    4. Identification of SH3 domain interaction partners of human FasL (CD178) by phage display screening. (PubMed id 19807924)1, 2 Voss M.... Janssen O. (BMC Immunol. 2009)
    5. Coeliac disease-associated risk variants in TNFAIP3 and REL implicate altered NF-kappaB signalling. (PubMed id 19240061)1, 4 Trynka G....Wijmenga C. (Gut 2009)
    6. Crystallographic structure of the SH3 domain of the human c-Yes tyrosine kinase: loop flexibility and amyloid aggregation. (PubMed id 17418139)1, 2 Martin-Garcia J.M....Camara-Artigas A. (FEBS Lett. 2007)
    7. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    8. Autophosphorylation of Src and Yes blocks their inactivation by Csk phosphorylation. (PubMed id 9794236)1, 2 Sun G.... Budde R.J. (Oncogene 1998)
    9. Differential expression of p62c-yes in normal, hyperplastic and neoplastic human epidermis. (PubMed id 2067846)1, 2 Krueger J.... Sudol M. (Oncogene 1991)
    10. Characterization of cDNA clones for the human c-yes gene. (PubMed id 2436037)1, 2 Sukegawa J.... Toyoshima K. (Mol. Cell. Biol. 1987)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 7525 HGNC: 12841 AceView: YES1 Ensembl:ENSG00000176105 euGenes: HUgn7525
    ECgene: YES1 Kegg: 7525 H-InvDB: YES1

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for YES1 Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for YES1 Genetics and Cytogenetics in Oncology and Haematology

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for YES1 gene:
    Search GeneIP for patents involving YES1

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, eBioscience, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
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