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Aliases & Descriptions for YEATS4
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc
, and/or 7Ensembl,
8miRBase) About This Section
|
| Aliases |
|---|
| 4930573H17Rik 2 | | B230215M10Rik 2 | | GAS41 1, 2, 3, 5 | | Gas41 3 | | NUBI-1 2 | | NuBI-1 1, 3 | | NuBI1 3 | | YAF9 1, 2 |
| | | Descriptions |
|---|
| Glioma-amplified sequence 41 3 | | NuMA binding protein 1 2 | | NuMA-binding protein 1 3 | | YEATS domain containing 4 2 | | glioma-amplified sequence-41 2 |
|
| | Search outside databases for aliases for YEATS4 gene |
Summaries for YEATS4(According to Entrez Gene,
Wikipedia's
Gene Wiki,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
| EntrezGene summary for YEATS4: The protein encoded by this gene is found in the nucleoli. It has high sequence homology to human MLLT1, and yeast and human MLLT3 proteins. Both MLLT1 and MLLT3 proteins belong to a class of transcription factors, indicating that the encoded protein might also represent a transcription factor. This protein is thought to be required for RNA transcription. This gene has been shown to be amplified in tumors. [provided by RefSeq] UniProtKB/Swiss-Prot: YETS4_HUMAN, O95619Function: Component of the NuA4 histone acetyltransferase (HAT) complex which is involved in transcriptional activation of select genes principally by acetylation of nucleosomal histones H4 and H2A. This modification may both alter nucleosome - DNA interactions and promote interaction of the modified histones with other proteins which positively regulate transcription. This complex may be required for the activation of transcriptional programs associated with oncogene and proto-oncogene mediated growth induction, tumor suppressor mediated growth arrest and replicative senescence, apoptosis, and DNA repair. NuA4 may also play a direct role in DNA repair when recruited to sites of DNA damage |
Genomic Location for YEATS4
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 36),
and/or miRBase,
Genomic Views according to
UCSC and
Ensembl,
Transcription factor binding sites according to
SABiosciences) About This Section
| Genomic View: UCSC Golden Path with GeneCards custom track
Transcription factor binding sites upstream to the YEATS4 gene 
Entrez Gene cytogenetic band: 12q13-q15 Ensembl cytogenetic band: 12q15 HGNC cytogenetic band: 12q13-q15YEATS4 Gene in genomic location: bands according to Ensembl, locations according to
(and/or Entrez Gene and/or Ensembl if different)
 GeneLoc gene densities for chromosome 12 GeneLoc Exon Structure GeneLoc location for GC12P068040:
(about GC identifiers)
Start:
|
68,039,799 bp from pter |
End:
|
68,070,843 bp from pter |
Size:
|
31,045 bases |
Orientation:
|
plus strand |
RefSeq DNA sequence:- NC_000012.10 NT_029419.11
| Proteins for YEATS4
(According to
1UniProtKB,
and/or Ensembl,
Phosphorylation sites according to 2Phosphosite,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from Invitrogen,
Millipore,
Sigma-Aldrich,
R&D Systems,
Enzo Life Sciences,
Abnova,
OriGene and/or,
Abcam,
Biochemical Assays by
Invitrogen,
Millipore,
R&D Systems,
Cell Signaling Technology, and/or
Enzo Life Sciences,
Ontologies according to Gene
Ontology Consortium 01 Apr 2009 and
Entrez Gene,
Antibodies by Invitrogen,
Millipore,
Sigma-Aldrich,
R&D Systems,
Cell Signaling Technology,
Abcam,
Abnova, and/or
Novus Biologicals)
About This Section
| UniProtKB/Swiss-Prot: YETS4_HUMAN, O95619 (See
protein sequence)Recommended Name: YEATS domain-containing protein 4 Size: 227 amino acids; 26499 Da
Subunit: Component of numerous complexes with chromatin remodeling and histone acetyltransferase activity. Component of the NuA4 histone acetyltransferase complex which contains the catalytic subunit HTATIP/TIP60 and the subunits EP400, TRRAP/PAF400, BRD8/SMAP, EPC1, DMAP1/DNMAP1, RUVBL1/TIP49, RUVBL2, ING3, actin, ACTL6A/BAF53A, MORF4L1/MRG15, MORF4L2/MRGX, MRGBP, YEATS4/GAS41, VPS72/YL1 and EAF6. The NuA4 complex interacts with MYC and the adenovirus E1A protein. Component of a NuA4-related complex which contains EP400, TRRAP/PAF400, SRCAP, BRD8/SMAP, EPC1, DMAP1/DNMAP1, RUVBL1/TIP49, RUVBL2, actin, ACTL6A/BAF53A, VPS72 and YEATS4/GAS41. YEATS4 interacts with MLLT10/AF10. YEATS4 may also interact with the SWI/SNF component SMARCB1/BAF47, TACC1 and TACC2, and the nuclear matrix protein NUMA1
Subcellular location: Nucleus
Secondary accessions: Q9NQD0REFSEQ proteins: NP_006521.1
ENSEMBL proteins: ENSP00000247843
Human Recombinant Proteins               OriGene Purified Recombinant Human Protein: YEATS4 
3 Gene Ontology (GO) cellular component terms (links to tree view): About this table
Antibodies for YEATS4: Assays for YEATS4: | Protein
Domains/ Families for YEATS4(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
| - Graphical View of Domain Structure for InterPro Entry O95619
ProtoNet protein and cluster: O95619 1 Blocks protein family: IPB005033 YEATS family
UniProtKB/Swiss-Prot: YETS4_HUMAN, O95619Similarity: Contains 1 YEATS domain | Gene Function for YEATS4
(According to MGI Jun 06 2009, UniProtKB,
IUBMB,and/or Genatlas,
shRNA from
OriGene,
Sigma-Aldrich, RNAi from
Sigma-Aldrich,
RNAi Products,
Clones, and
Q-PCR Products
from Invitrogen,
Millipore,
OriGene, and/or
Abnova,
siRNAs from
Applied Biosystems,
SYBR primers from OriGene,
Cell-based Assays from Millipore,
Ontologies according to Gene Ontology Consortium 01 Apr 2009 via
Entrez Gene.)
About This Section
|               OriGene 29mer shRNA kit in GFP-retroviral vector: NM_006530
Applied Biosystems Silencer® siRNAs for YEATS4
Sigma-Aldrich siRNA for YEATS4  Sigma-Aldrich shRNA for YEATS4  Explore Sigma-Aldrich super-pooled esiRNAs 
              OriGene GFP tagged cDNA clone in CMV expression vector: NM_006530                                  Myc/DDK tagged cDNA clone in CMV expression vector: NM_006530                                  untagged cDNA clones in CMV expression vector (see all 2): NM_006530 
Primers: Browse
Quantitative PCR Central at Invitrogen for Q-PCR LUX™ Primers               OriGene genome-wide validated SYBR primer pairs: NM_006530
UniProtKB/Swiss-Prot: YETS4_HUMAN, O95619Function: Component of the NuA4 histone acetyltransferase (HAT) complex which is involved in transcriptional activation of select genes principally by acetylation of nucleosomal histones H4 and H2A. This modification may both alter nucleosome - DNA interactions and promote interaction of the modified histones with other proteins which positively regulate transcription. This complex may be required for the activation of transcriptional programs associated with oncogene and proto-oncogene mediated growth induction, tumor suppressor mediated growth arrest and replicative senescence, apoptosis, and DNA repair. NuA4 may also play a direct role in DNA repair when recruited to sites of DNA damage3 Gene Ontology (GO) molecular function terms (links to tree view): About this table | Pathways & Interactions for YEATS4
(Pathways according to Invitrogen
(maps by GeneGo),
Millipore,
Cell Signaling Technology,
Sigma-Aldrich,
KEGG
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Proteins Network according to
SABiosciences,
Interactions according to 1UniProtKB,
2MINT, and/or
3STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Apr 2009 via
Entrez Gene.)
About This Section
|
Gene Network CentralTM Interacting Genes and Proteins Network for YEATS4 
5/23 Interacting proteins for YEATS4 (O956191 ENSP000002478433) via UniProtKB, MINT, and/or STRING (see all 23
)About this table
5 Gene Ontology (GO) biological process terms (links to tree view): About this table
|
Drugs & Compounds for YEATS4(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
Sigma-Aldrich, Tocris Bioscience, and/or
Novoseek and Drugs according to
Enzo Life Sciences and/or
PharmGKB)
About This Section
|
Browse Tocris compounds for YEATS4
|
Transcripts for YEATS4(GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 219 Homo sapiens; Jun 2 2009) or GenBank, RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
non coding RNAs according to
RNAdb,
ESTs according to GeneTide,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from Invitrogen,
Millipore, and/or
Abnova,
siRNAs from Applied Biosystems,
Sigma-Aldrich,
shRNA from
Sigma-Aldrich,
OriGene,
Tagged/untagged cDNA clones from
OriGene, Expression Assays from Applied Biosystems) About This Section
|               OriGene 29mer shRNA kit in GFP-retroviral vector: NM_006530
Sigma-Aldrich siRNA for YEATS4  Sigma-Aldrich shRNA for YEATS4  Explore Sigma-Aldrich super-pooled esiRNAs 
Applied Biosystems Silencer® siRNAs: NM_006530 REFSEQ mRNAs for YEATS4 gene: NM_006530.2
Applied Biosystems TaqMan ® Gene Expression Assays: NM_006530               OriGene GFP tagged cDNA clone in CMV expression vector: NM_006530                                  Myc/DDK tagged cDNA clone in CMV expression vector: NM_006530                                  untagged cDNA clones in CMV expression vector (see all 2): NM_006530  Additional cDNA sequence: AJ245746.1 AK001413.1 BC000994.2 BX640958.1 U61384.1 6 DOTS entries: DT.414973 DT.99982350 DT.100782453 DT.95169503 DT.100023404 DT.121125477 6 AceView cDNA sequences:AK001413 NM_006530 U61384 BC000994 BX640958 AJ245746
highest scoring ESTs for YEATS4:AA507602 AA835883 AJ245746 BC000994 BG193950 BG206291 BG209931 U61384 Z78373 AA427613 Unigene Cluster for YEATS4: YEATS domain containing 4 Hs.4029 [show with all ESTs]Unigene Representative Sequence: BX640958
GeneLoc Exon Structure
5 Alternative Splicing Database (ASD) splice patterns (SP) for YEATS4
| ExUns: | 1a | · | 1b | · | 1c | ^ | 2 | ^ | 3 | ^ | 4 | ^ | 5 | ^ | 6 | ^ | 7 | ^ | 8 | ^ | 9a | · | 9b | |
| SP1: | |   | |   | |   | - |   | |   | - |   | |   | |   | |   | |   | |   | |   | |
| SP2: | |   | |   | |   | - |   | |   | |   | |   | |   | |   | |   | |   | |   | |
| SP3: | |   | |   | |   | |   | |   | - |   | |   | |   | |   | |   | |   | |   | |
| SP4: | |   | |   | |   | - |   | |   | - |   | - |   | - |   | |   | |   | |   | |   | |
| SP5: | |   | |   | |   | |   | |   | - |   | - |   | - |   | |   | |   | |   | |   |
About this scheme
ECgene alternative splicing isoforms for YEATS4
1 Ensembl transcript including schematic representation: ENST00000247843
|
Expression for YEATS4
(Experimental results according to
1GeneNote
and GNF BioGPS,
probe sets-to-genes annotations according to
2GeneAnnot ,
3GeneTide ,
Sets of similar genes according to GeneDecks,
Electronic Northern calculations according to data from
UniGene (Build 219 Homo sapiens),
SAGE tags according to
CGAP,
plus additional links to
SOURCE, and/or
GNF
BioGPS, and/or
EXPOLDB, and/or
UniProtKB,
Expression Assays from
Applied Biosystems
)
About This Section
| YEATS4 expression in normal and diseased human tissues
Applied Biosystems TaqMan ® Gene Expression Assays for YEATS4
1 / 2 / 3 3 probe-sets matching YEATS4 gene Data from
(Publications) and GNF BioGPS About these images About these images
CGAP SAGE TAG: AATTTCTTAG
SOURCE GeneReport for Unigene cluster: Hs.4029 UniProtKB/Swiss-Prot: YETS4_HUMAN, O95619Tissue specificity: Expressed in brain, heart, kidney, liver, lung, pancreas, placenta and skeletal muscle |
Orthologs for YEATS4
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
and/or
5MGI Jun 06 2009,
with possible further links to
Flybase
and/or
WormBase,
Gene Trees according to Ensembl)
About This Section
|
Orthologs for YEATS4 gene from 5/19 species (see all 19
)
About this table Species with no ortholog for YEATS4
ENSEMBL Gene Tree for YEATS4 | Paralogs for YEATS4(Paralogs according to 1HomoloGene and 2Ensembl, Pseudogenes according to 3Pseudogene.org) About This Section
| Paralogs for YEATS4 gene
- YEATS22
|
SNPs/Variants for YEATS4(According to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE, and
UniProtKB,
Linkage Disequilibrium by HapMap,
Genotyping Reagents from
Applied Biosystems)
About This Section
|
HapMap Linkage Disequilibrium images for YEATS4 (up to first 250kb)
|
Disorders & Mutations for YEATS4
(in which this Gene is Involved, According to
OMIM, UniProtKB,
Novoseek, PharmGKB,
Genatlas, GeneTests,
Blood group antigen gene mutations by BGMUT,
HGMD, GAD,
HuGE Navigator,
BCGD,
and/or TGDB.)
About This Section
|
OMIM: 602116 2 Novoseek disease relationships for YEATS4 gene
About this table
Human Genome Epidemiology Navigator: YEATS4 (1 document)
|
Medical News for YEATS4(Possibly Related Articles in
Doctor's Guide)
About This Section
| -- |
Publications for YEATS4 (in
PubMed.
Associations of this gene to articles via
1Novoseek,
2HGNC,
3Entrez Gene,
4UniProtKB/Swiss-Prot,
5UniProtKB/TrEMBL,
6GAD, and/or
7PharmGKB)
About This Section
| 10/20 PubMed articles for YEATS4 gene (see all 20
):- Cloning of a novel transcription factor-like gene amplified in human glioma including astrocytoma grade I. (PubMed id 9302258)1, 2, 3, 4 Fischer U.... Meese E. (1997)
- Interaction of the transforming acidic coiled-coil 1 (TACC1) protein with ch-TOG and GAS41/NuBI1 suggests multiple TACC1-containing protein complexes in human cells. (PubMed id 11903063)1, 2, 3, 4 Lauffart B....Still I.H. (2002)
- The highly conserved and multifunctional NuA4 HAT complex. (PubMed id 15196461)3, 4 Doyon Y. and Cote J. (2004)
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)3, 4 Gerhard D.S....Malek J. (2004)
- Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)3, 4 Ota T....Sugano S. (2004)
- Structural and functional conservation of the NuA4 histone acetyltransferase complex from yeast to humans. (PubMed id 14966270)3, 4 Doyon Y.... Cote J. (2004)
- Molecular cloning, genomic structure and interactions of the putative breast tumor suppressor TACC2. (PubMed id 12620397)3, 4 Lauffart B.... Still I.H. (2003)
- Identification of new subunits of the multiprotein mammalian TRRAP/TIP60-containing histone acetyltransferase complex. (PubMed id 12963728)3, 4 Cai Y.... Conaway J.W. (2003)
- The MLL fusion partner AF10 binds GAS41, a protein that interacts with the human SWI/SNF complex. (PubMed id 11756182)3, 4 Debernardi S.... Young B.D. (2002)
- GAS41, a highly conserved protein in eukaryotic nuclei, binds to NuMA. (PubMed id 10913114)3, 4 Harborth J.... Osborn M. (2000)
|
Search for YEATS4
(in PubMed,
OMIM, and NCBI Bookshelf) About This Section
|
|
Genome Databases showing YEATS4
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
and/or
H-InvDB)
About This Section
|
| Other Databases showing YEATS4
(According to HUGE)
About This Section
| -- |
Specialized Databases showing YEATS4(According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL, Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot) About This Section
|
| About This Section
| --
| Services for YEATS4(Reagents available from Applied Biosystems, Antibodies and assays by Cell
Signaling Technology, Abcam, Novus Biologicals, Sigma-Aldrich, R&D Systems, Millipore, Abnova, and/or Invitrogen, Clones available from OriGene,and/or Invitrogen, Drugs and/or compounds by Sigma-Aldrich, Enzo Life Sciences, and/or Tocris Bioscience) About This Section
| 
 Products for YEATS4:

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Incremental update: 13 Oct 2009
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