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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

YEATS4 Gene

protein-coding   GIFtS: 56
GCID: GC12P069753

YEATS domain containing 4

 Explore 3 diseases affiliated with
YEATS4 via our new
 Human Malady Compendium 
Biological research products
for YEATS4
    

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, and/or 10fRNAdb)
About This Section

Aliases
YEATS Domain Containing 41 2     NUBI-12
GAS411 2 3 5     Glioma-Amplified Sequence-412
YAF91 2     NuBI13
NuBI-11 3     NuMA Binding Protein 12
Glioma-Amplified Sequence 412 3     YEATS Domain-Containing Protein 42
NuMA-Binding Protein 12 3     Gas413
4930573H17Rik2     NuBI13
B230215M10Rik2     

External Ids:    HGNC: 248591   Entrez Gene: 80892   Ensembl: ENSG000001273377   OMIM: 6021165   UniProtKB: O956193   

Export aliases for YEATS4 gene to outside databases

Previous GC identifers: GC12P068040 GC12P066803


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for YEATS4:
The protein encoded by this gene is found in the nucleoli. It has high sequence homology to human MLLT1, and yeast and
human MLLT3 proteins. Both MLLT1 and MLLT3 proteins belong to a class of transcription factors, indicating that the
encoded protein might also represent a transcription factor. This protein is thought to be required for RNA
transcription. This gene has been shown to be amplified in tumors. (provided by RefSeq, Jul 2008)

UniProtKB/Swiss-Prot: YETS4_HUMAN, O95619
Function: Component of the NuA4 histone acetyltransferase (HAT) complex which is involved in transcriptional activation
of select genes principally by acetylation of nucleosomal histones H4 and H2A. This modification may both alter
nucleosome - DNA interactions and promote interaction of the modified histones with other proteins which positively
regulate transcription. This complex may be required for the activation of transcriptional programs associated with
oncogene and proto-oncogene mediated growth induction, tumor suppressor mediated growth arrest and replicative
senescence, apoptosis, and DNA repair. NuA4 may also play a direct role in DNA repair when recruited to sites of DNA
damage




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000012.11  NC_018923.1  NT_029419.12  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the YEATS4 gene promoter:
         C/EBPbeta   AP-1   p53   XBP-1   AP-4   CUTL1   GATA-2   AREB6   FOXO1a   FOXO1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidYEATS4 promoter sequence
   Search SABiosciences Chromatin IP Primers for YEATS4

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat YEATS4


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 12q13-q15   Ensembl cytogenetic band:  12q15   HGNC cytogenetic band: 12q13-q15

YEATS4 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
YEATS4 gene location

GeneLoc information about chromosome 12         GeneLoc Exon Structure

GeneLoc location for GC12P069753:  view genomic region     (about GC identifiers)

Start:
69,753,483 bp from pter      End:
69,784,576 bp from pter
Size:
31,094 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section

UniProtKB/Swiss-Prot: YETS4_HUMAN, O95619 (See protein sequence)
Recommended Name: YEATS domain-containing protein 4  
Size: 227 amino acids; 26499 Da
Subunit: Component of numerous complexes with chromatin remodeling and histone acetyltransferase activity. Component of
the NuA4 histone acetyltransferase complex which contains the catalytic subunit KAT5/TIP60 and the subunits EP400,
TRRAP/PAF400, BRD8/SMAP, EPC1, DMAP1/DNMAP1, RUVBL1/TIP49, RUVBL2, ING3, actin, ACTL6A/BAF53A, MORF4L1/MRG15,
MORF4L2/MRGX, MRGBP, YEATS4/GAS41, VPS72/YL1 and MEAF6. The NuA4 complex interacts with MYC and the adenovirus E1A
protein. Component of a NuA4-related complex which contains EP400, TRRAP/PAF400, SRCAP, BRD8/SMAP, EPC1, DMAP1/DNMAP1,
RUVBL1/TIP49, RUVBL2, actin, ACTL6A/BAF53A, VPS72 and YEATS4/GAS41. YEATS4 interacts with MLLT10/AF10. YEATS4 may also
interact with the SWI/SNF component SMARCB1/BAF47, TACC1 and TACC2, and the nuclear matrix protein NUMA1
Subcellular location: Nucleus
Sequence caution: Sequence=CAC01935.1; Type=Erroneous initiation;
Secondary accessions: Q9NQD0

Explore the universe of human proteins at neXtProt for YEATS4: NX_O95619

Post-translational modifications:

  • View modification sites using PhosphoSitePlus2
  • View neXtProt modification sites for NX_O95619

  • YEATS4 Protein expression data from MOPED and PaxDb:    About this image 
    YEATS4 Protein Expression
    REFSEQ proteins: NP_006521.1  
    ENSEMBL proteins: 
     ENSP00000247843   ENSP00000447199   ENSP00000448106   ENSP00000446985  

    Human Recombinant Protein Products for YEATS4: 
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    ProSpec Recombinant Protein for YEATS4
    Uscn Proteins for YEATS4

    Gene Ontology (GO): 4 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus ----
    GO:0005654nucleoplasm IDA10913114
    GO:0016363nuclear matrix NAS10913114
    GO:0035267NuA4 histone acetyltransferase complex IDA14966270

    YEATS4 for ontologies           About GeneDecksing



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    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section

    YEATS4 for domains           About GeneDecksing

    1 InterPro domain/family:
     IPR005033 YEATS

    Graphical View of Domain Structure for InterPro Entry O95619

    ProtoNet protein and cluster: O95619

    1 Blocks protein family: IPB005033 YEATS family

    UniProtKB/Swiss-Prot: YETS4_HUMAN, O95619
    Similarity: Contains 1 YEATS domain


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, Sirion Biotech, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, Sirion Biotech, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: YETS4_HUMAN, O95619
    Function: Component of the NuA4 histone acetyltransferase (HAT) complex which is involved in transcriptional activation
    of select genes principally by acetylation of nucleosomal histones H4 and H2A. This modification may both alter
    nucleosome - DNA interactions and promote interaction of the modified histones with other proteins which positively
    regulate transcription. This complex may be required for the activation of transcriptional programs associated with
    oncogene and proto-oncogene mediated growth induction, tumor suppressor mediated growth arrest and replicative
    senescence, apoptosis, and DNA repair. NuA4 may also play a direct role in DNA repair when recruited to sites of DNA
    damage

         Gene Ontology (GO): 5 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003677DNA binding TAS9302258
    GO:0003700sequence-specific DNA binding transcription factor activity TAS9302258
    GO:0005200structural constituent of cytoskeleton NAS10913114
    GO:0005515protein binding IPI11903063
    GO:0008022protein C-terminus binding IPI10913114
         
    YEATS4 for ontologies           About GeneDecksing


    Phenotypes:
         2 GenomeRNAi human phenotypes for YEATS4:
     Decreased Hepatitis C virus re  Increased HPV18 LCR reporter a 

    Animal Models:
       inGenious Targeting Laboratory - Customizable classic, inducible, and humanized mouse model solutions for YEATS4 

    miRNA
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    Browse MicroRNA Expression Plasmids
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat YEATS4
    3 QIAGEN miScript miRNA Assays for microRNAs that regulate YEATS4:
    hsa-miR-218 hsa-miR-3941 hsa-miR-636
    SwitchGear 3'UTR luciferase reporter plasmidYEATS4 3' UTR sequence
    Inhib. RNA
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    Sirion Biotech Custom design and validation of potent shRNA sequences against YEATS4 

    Gene Editing
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    In Situ Assay
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for YEATS4


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
    About This Section

    Unified GeneCards pathways  About this table 
    See pathways by source

    Super-pathwaycontained gene-specific pathways
    1C-MYB transcription factor network
    C-MYB transcription factor network1.00


    1 BioSystems Pathway for YEATS4 
        C-MYB transcription factor network


    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for YEATS4

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    5/662 Interacting proteins for YEATS4 (O956191, 2, 3 ENSP000002478434) via UniProtKB, MINT, STRING, and/or I2D (see all 662)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    HIST1H4AP628053I2D: score=1 
    HIST1H4BP628053I2D: score=1 
    HIST1H4CP628053I2D: score=1 
    HIST1H4DP628053I2D: score=1 
    HIST1H4EP628053I2D: score=1 
    About this table

    Gene Ontology (GO): 5/7 biological process terms (GO ID links to tree view) (see all 7):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006351transcription, DNA-dependent IEA--
    GO:0006355regulation of transcription, DNA-dependent ----
    GO:0007067mitosis NAS10913114
    GO:0040008regulation of growth IEA--
    GO:0043967histone H4 acetylation IDA14966270

    YEATS4 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section

    YEATS4 for compounds           About GeneDecksing

    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for YEATS4
    1 PharmGKB related drug/compound annotation for YEATS4 gene    About this table
    Drug/compound PharmGKB Annotation
    hydrochlorothiazideCA  
    Search CenterWatch for drugs/clinical trials and news about YEATS4 / YETS4 

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, Sirion Biotech, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for YEATS4 gene: 
    NM_006530.2  

    Unigene Cluster for YEATS4:

    YEATS domain containing 4
    Hs.4029  [show with all ESTs]
    Unigene Representative Sequence: BX640958
    5 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000247843(uc001sux.3) ENST00000548020 ENST00000549685 ENST00000552949
    ENST00000552955

    miRNA
    Products:
         
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    Browse OriGene MicroRNA Expression Plasmids
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat YEATS4
    3 QIAGEN miScript miRNA Assays for microRNAs that regulate YEATS4:
    hsa-miR-218 hsa-miR-3941 hsa-miR-636
    SwitchGear 3'UTR luciferase reporter plasmidYEATS4 3' UTR sequence
    Inhib. RNA
    Products:
         
    Browse for Gene Knock-down Tools from EMD Millipore
    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for YEATS4 (see all 7)
    OriGene shRNA RFP: YEATS4
    OriGene siRNA: YEATS4
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat YEATS4
    Sirion Biotech Custom design and validation of potent shRNA sequences against YEATS4 
    Clone
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    OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for YEATS4 (see all 2)
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling 
    GenScript: all cDNA clones in your preferred vector: YEATS4 (NM_006530)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for YEATS4
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat YEATS4 
    Primer
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    OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for YEATS4
    Browse OriGene validated miRNA SYBR primer pairs
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      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat YEATS4
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat YEATS4

    Additional cDNA sequence: 

    AJ245746.1 AK001413.1 BC000994.2 BX640958.1 U61384.1 

    6 DOTS entries:

    DT.414973  DT.99982350  DT.100782453  DT.95169503  DT.100023404  DT.121125477 

    6 AceView cDNA sequences:

    U61384 AK001413 BC000994 NM_006530 AJ245746 BX640958 

    GeneLoc Exon Structure

    5 Alternative Splicing Database (ASD) splice patterns (SP) for YEATS4    About this scheme

    ExUns: 1a · 1b · 1c ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9a · 9b
    SP1:                    -           -                                       
    SP2:                    -                                                   
    SP3:                                -                                       
    SP4:                    -           -     -     -                           
    SP5:                                -     -     -                           


    ECgene alternative splicing isoforms for YEATS4

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    YEATS4 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS
    CGAP TAG: AATTTCTTAG
    YEATS4 Expression
    About this image
    See YEATS4 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for YEATS4

    SOURCE GeneReport for Unigene cluster: Hs.4029

    UniProtKB/Swiss-Prot: YETS4_HUMAN, O95619
    Tissue specificity: Expressed in brain, heart, kidney, liver, lung, pancreas, placenta and skeletal muscle

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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for YEATS4

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of eukaryotes.

    Orthologs for YEATS4 gene from 10/33 species (see all 33)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Yeats41 , 5 YEATS domain containing 41, 5 88.55(n)1
    99.56(a)1
      10 (65.26 cM)5
    640501  NM_026570.41  NP_080846.11 
     1172151425 
    chicken
    (Gallus gallus)
    Aves YEATS41 YEATS domain containing 4 80.32(n)
    97.36(a)
      771226  NM_001079503.1  NP_001072971.1 
    lizard
    (Anolis carolinensis)
    Reptilia YEATS46
    --
    97(a)
    1 ↔ 1
    GL343256.1(1569933-1574033)
    African clawed frog
    (Xenopus laevis)
    Amphibia BC060411.12   -- 82.56(n)    BC060411.1 
    zebrafish
    (Danio rerio)
    Actinopterygii yeats41 YEATS domain containing 4 73.78(n)
    91.56(a)
      437025  NM_001002752.1  NP_001002752.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta Gas411 CG9207-PA 59.1(n)
    62.04(a)
      33973  NM_135242.2  NP_609086.1 
    worm
    (Caenorhabditis elegans)
    Secernentea gfl-11 Protein GFL-1 52.68(n)
    49.27(a)
      187434  NM_069771.1  NP_502172.1 
    baker's yeast
    (Saccharomyces cerevisiae)
    Saccharomycetes YAF9(YNL107W)4
    YAF91
    Subunit of both the NuA4 histone H4 acetyltransferase more4
    Yaf9p1
    50.83(n)1
    37.5(a)1
      14(420098-420778)4
    8556161, 4  NP_014292.31  NP_014292.14 
    thale cress
    (Arabidopsis thaliana)
    eudicotyledons GAS416
    TAF146
    TBP-associated factor 14
    27(a)
    25(a)
    many ↔ many
    many ↔ many
    5(18487902-18489869)
    2(7829035-7830580)
    rice
    (Oryza sativa)
    Liliopsida --
    transcription factor TFIIF, putative, expressed
    23(a)
    1 → many
    6(1989030-1992737)


    ENSEMBL Gene Tree for YEATS4 (if available)
    TreeFam Gene Tree for YEATS4 (if available) 

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for YEATS4 gene
    YEATS22  
    2 SIMAP similar genes for YEATS4 using alignment to 4 protein entries:     YETS4_HUMAN (see all proteins):
    YEATS2    MLLT3

    YEATS4 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/636 NCBI SNPs in YEATS4 are shown (see all 636    About this table
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 12 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1483041561,2
    --69751765(+) CCAATC/TGTTTT 1 -- us2k10--------
    rs1926309901,2
    --69751788(+) GCCCCA/CAAACC 1 -- us2k10--------
    rs1413956851,2
    --69751878(+) CTTGGC/TTGAAA 1 -- us2k10--------
    rs5884931,2
    C,F,A--69751986(+) AAAAAG/ATATTT 1 -- us2k113Minor allele frequency- A:0.46NA EA WA CSA 592
    rs5894481,2
    C,F,A,H--69752200(+) CAAGCA/GTAGTA 1 -- us2k121Minor allele frequency- G:0.45NS EA NA WA CSA 2348
    rs766152941,2
    C--69752214(+) TTCTCC/TAAAGC 1 -- us2k12Minor allele frequency- T:0.08NA 122
    rs5188201,2
    C,F--69752278(+) GTTTTT/GTTTTG 1 -- us2k17Minor allele frequency- G:0.49NA WA CSA EA 131
    rs1447812391,2
    --69752288(+) GTTTT-/GTTTTT 1 -- us2k10--------
    rs714361021,2
    C--69752289(+) TTTTTT/-GAGAC 1 -- us2k11Minor allele frequency- -:0.50NA 2
    rs5194901,2
    C--69752293(+) GTTTTG/TTTTTT 1 -- us2k1 trp31Minor allele frequency- T:0.00WA 2

    HapMap Linkage Disequilibrium report for YEATS4 (69753483 - 69784576 bp)
    Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
          Database of Genomic Variants (DGV) variations for YEATS4: --

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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section

    YEATS4 for disorders           About GeneDecksing

    OMIM gene information: 602116    OMIM disorders: --

    3 diseases for YEATS4:    About MalaCards
    liposarcoma    astrocytoma    malaria

    1 disease from the University of Copenhagen DISEASES database for YEATS4:
    Liposarcoma

    2 Novoseek disease relationships for YEATS4 gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    glioma 40.2 2 11903063 (1), 9302258 (1)
    tumors 0 7 16705155 (5), 9302258 (1)

    Human Genome Epidemiology (HuGE) Navigator: YEATS4 (1 document)

    Export disorders for YEATS4 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for YEATS4 gene, integrated from 9 sources (see all 35):
    (articles sorted by number of sources associating them with YEATS4)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Cloning of a novel transcription factor-like gene amplified in human glioma including astrocytoma grade I. (PubMed id 9302258)1, 2, 3, 9 Fischer U.... Meese E. (1997)
    2. Interaction of the transforming acidic coiled-coil 1 (TACC1) protein with ch-TOG and GAS41/NuBI1 suggests multiple TACC1-containing protein complexes in human cells. (PubMed id 11903063)1, 2, 3, 9 Lauffart B.... Still I.H. (2002)
    3. The highly conserved and multifunctional NuA4 HAT complex. (PubMed id 15196461)1, 2 Doyon Y. and Cote J. (2004)
    4. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
    5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    6. Structural and functional conservation of the NuA4 histone acetyltransferase complex from yeast to humans. (PubMed id 14966270)1, 2 Doyon Y.... Cote J. (2004)
    7. Molecular cloning, genomic structure and interactions of the putative breast tumor suppressor TACC2. (PubMed id 12620397)1, 2 Lauffart B.... Still I.H. (2003)
    8. Identification of new subunits of the multiprotein mammalian TRRAP/TIP60-containing histone acetyltransferase complex. (PubMed id 12963728)1, 2 Cai Y.... Conaway J.W. (2003)
    9. The MLL fusion partner AF10 binds GAS41, a protein that interacts with the human SWI/SNF complex. (PubMed id 11756182)1, 2 Debernardi S.... Young B.D. (2002)
    10. GAS41, a highly conserved protein in eukaryotic nuclei, binds to NuMA. (PubMed id 10913114)1, 2 Harborth J.... Osborn M. (2000)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 8089 HGNC: 24859 AceView: YEATS4 Ensembl:ENSG00000127337 euGenes: HUgn8089
    ECgene: YEATS4 H-InvDB: YEATS4

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for YEATS4 Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for YEATS4 Genetics and Cytogenetics in Oncology and Haematology

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for YEATS4 gene:
    Search GeneIP for patents involving YEATS4

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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