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YEATS4 Gene

protein-coding   GIFtS: 56

GC12P068040
YEATS domain containing 4
Symbol approved by the HUGO Gene Nomenclature Committee (HGNC) database
Services    
(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc , and/or 7Ensembl, 8miRBase)
About This Section

Aliases
4930573H17Rik 2
B230215M10Rik 2
GAS41 1, 2, 3, 5
Gas41 3
NUBI-1 2
NuBI-1 1, 3
NuBI1 3
YAF9 1, 2
Descriptions
Glioma-amplified sequence 41 3
NuMA binding protein 1 2
NuMA-binding protein 1 3
YEATS domain containing 4 2
glioma-amplified sequence-41 2
External Ids
HGNC: 248591
Entrez Gene: 80892
UniProtKB: O956193
Ensembl: ENSG000001273377
Search outside databases for aliases for YEATS4 gene

(According to Entrez Gene, Wikipedia's Gene Wiki,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

EntrezGene summary for YEATS4:
The protein encoded by this gene is found in the nucleoli. It has high sequence homology to human
MLLT1, and yeast and human MLLT3 proteins. Both MLLT1 and MLLT3 proteins belong to a class of
transcription factors, indicating that the encoded protein might also represent a transcription
factor. This protein is thought to be required for RNA transcription. This gene has been shown to
be amplified in tumors. [provided by RefSeq]

UniProtKB/Swiss-Prot: YETS4_HUMAN, O95619
Function: Component of the NuA4 histone acetyltransferase (HAT) complex which is involved in
transcriptional activation of select genes principally by acetylation of nucleosomal histones H4
and H2A. This modification may both alter nucleosome - DNA interactions and promote interaction of
the modified histones with other proteins which positively regulate transcription. This complex
may be required for the activation of transcriptional programs associated with oncogene and
proto-oncogene mediated growth induction, tumor suppressor mediated growth arrest and replicative
senescence, apoptosis, and DNA repair. NuA4 may also play a direct role in DNA repair when
recruited to sites of DNA damage

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 36),
and/or miRBase,
Genomic Views according to UCSC and Ensembl, Transcription factor binding sites according to SABiosciences)
About This Section

Genomic View:
UCSC Golden Path with GeneCards custom track

 Transcription factor binding sites upstream to the YEATS4 gene  

Entrez Gene cytogenetic band: 12q13-q15   Ensembl cytogenetic band:  12q15   HGNC cytogenetic band: 12q13-q15

YEATS4 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)

GeneLoc gene densities for chromosome 12         GeneLoc Exon Structure

GeneLoc location for GC12P068040:     (about GC identifiers)

Start:
68,039,799 bp from pter
End:
68,070,843 bp from pter
Size:
31,045 bases
Orientation:
plus strand
RefSeq DNA sequence:
NC_000012.10  NT_029419.11  
(According to 1UniProtKB, and/or Ensembl, Phosphorylation sites according to 2Phosphosite, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Enzo Life Sciences, Abnova, OriGene and/or, Abcam,
Biochemical Assays by Invitrogen, Millipore, R&D Systems, Cell Signaling Technology, and/or Enzo Life Sciences, Ontologies according to Gene Ontology Consortium 01 Apr 2009 and Entrez Gene, Antibodies by Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Cell Signaling Technology, Abcam, Abnova, and/or Novus Biologicals)
About This Section

UniProtKB/Swiss-Prot: YETS4_HUMAN, O95619 (See protein sequence)
Recommended Name: YEATS domain-containing protein 4  
Size: 227 amino acids; 26499 Da
Subunit: Component of numerous complexes with chromatin remodeling and histone acetyltransferase
activity. Component of the NuA4 histone acetyltransferase complex which contains the catalytic
subunit HTATIP/TIP60 and the subunits EP400, TRRAP/PAF400, BRD8/SMAP, EPC1, DMAP1/DNMAP1,
RUVBL1/TIP49, RUVBL2, ING3, actin, ACTL6A/BAF53A, MORF4L1/MRG15, MORF4L2/MRGX, MRGBP,
YEATS4/GAS41, VPS72/YL1 and EAF6. The NuA4 complex interacts with MYC and the adenovirus E1A
protein. Component of a NuA4-related complex which contains EP400, TRRAP/PAF400, SRCAP, BRD8/SMAP,
EPC1, DMAP1/DNMAP1, RUVBL1/TIP49, RUVBL2, actin, ACTL6A/BAF53A, VPS72 and YEATS4/GAS41. YEATS4
interacts with MLLT10/AF10. YEATS4 may also interact with the SWI/SNF component SMARCB1/BAF47,
TACC1 and TACC2, and the nuclear matrix protein NUMA1
Subcellular location: Nucleus
Secondary accessions: Q9NQD0

REFSEQ proteins: NP_006521.1  

ENSEMBL proteins: 
ENSP00000247843 


Human Recombinant Proteins 
Browse Drug Discovery Central at Invitrogen for human recombinant proteins
Browse Purified and Recombinant Proteins at Millipore
Browse Human Recombinant Proteins at Sigma-Aldrich  
Browse R&D Systems for human recombinant proteins
Browse recombinant and purified proteins available from Enzo Life Sciences
Recombinant Proteins from Abcam (GAS41)
Human Recombinant Proteins from Abnova (YEATS4)
              OriGene Purified Recombinant Human Protein: YEATS4 

3 Gene Ontology (GO) cellular component terms (links to tree view):

GO IDQualified GO termEvidencePubMed IDs
GO:0005634 nucleus TAS9302258
GO:0005654 nucleoplasm IDA10913114
GO:0016363 nuclear matrix NAS10913114
About this table

Antibodies for YEATS4: 
Browse Antibodies Central at Invitrogen
Browse Millipore's Extensive Line of Mono- and Polyclonal Antibodies
Sigma-Aldrich Antibodies for YEATS4
Browse R&D Systems for Antibodies
Antibodies from Abcam (GAS41), each with their AbpromiseSM
Monoclonal and Polyclonal Antibodies from Abnova (YEATS4)
Novus Biologicals Antibodies for YEATS4

Assays for YEATS4: 
Browse Invitrogen for biochemical assays
Browse Kits and Assays available from Millipore
Browse R&D Systems for biochemical assays
Browse biochemical assays available from Enzo Life Sciences

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

1 InterPro domain/family:
 IPR005033 YEATS


   GeneDecks  YEATS4 for the domains selected above  
About GeneDecksing

Graphical View of Domain Structure for InterPro Entry O95619

ProtoNet protein and cluster: O95619

1 Blocks protein family: IPB005033 YEATS family

UniProtKB/Swiss-Prot: YETS4_HUMAN, O95619
Similarity: Contains 1 YEATS domain

(According to MGI Jun 06 2009, UniProtKB, IUBMB,and/or Genatlas,
shRNA from OriGene, Sigma-Aldrich, RNAi from Sigma-Aldrich,
RNAi Products, Clones, and Q-PCR Products from Invitrogen, Millipore, OriGene, and/or Abnova, siRNAs from Applied Biosystems, SYBR primers from OriGene, Cell-based Assays from Millipore, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
About This Section

Inhib.
RNA:
Invitrogen RNAi Products for gene knock-down (YEATS4)
Browse for Gene Knock-down Tools from Millipore
Abnova Chimera RNAi Products for Gene knock-down (YEATS4)
              OriGene 29mer shRNA kit in GFP-retroviral vector: NM_006530

              Applied Biosystems Silencer® siRNAs for YEATS4

              Sigma-Aldrich siRNA for YEATS4  
                     Sigma-Aldrich shRNA for YEATS4  
                     Explore Sigma-Aldrich super-pooled esiRNAs  

Clones:Invitrogen Clones for YEATS4
Browse Clones for the Expression of Recombinant Proteins Available from Millipore
              OriGene GFP tagged cDNA clone in CMV expression vector: NM_006530
                                 Myc/DDK tagged cDNA clone in CMV expression vector: NM_006530
                                 untagged cDNA clones in CMV expression vector (see all 2): NM_006530 

Primers: Browse Quantitative PCR Central at Invitrogen for Q-PCR LUX™ Primers
              OriGene genome-wide validated SYBR primer pairs: NM_006530

UniProtKB/Swiss-Prot: YETS4_HUMAN, O95619
Function: Component of the NuA4 histone acetyltransferase (HAT) complex which is involved in
transcriptional activation of select genes principally by acetylation of nucleosomal histones H4
and H2A. This modification may both alter nucleosome - DNA interactions and promote interaction of
the modified histones with other proteins which positively regulate transcription. This complex
may be required for the activation of transcriptional programs associated with oncogene and
proto-oncogene mediated growth induction, tumor suppressor mediated growth arrest and replicative
senescence, apoptosis, and DNA repair. NuA4 may also play a direct role in DNA repair when
recruited to sites of DNA damage

3 Gene Ontology (GO) molecular function terms (links to tree view):

GO IDQualified GO termEvidencePubMed IDs
GO:0003700 transcription factor activity TAS9302258
GO:0005200 structural constituent of cytoskeleton NAS10913114
GO:0008022 protein C-terminus binding IPI10913114
About this table

(Pathways according to Invitrogen (maps by GeneGo), Millipore, Cell Signaling Technology, Sigma-Aldrich, KEGG and/or UniProtKB,
Sets of similar genes according to GeneDecks, Proteins Network according to SABiosciences, Interactions according to 1UniProtKB, 2MINT, and/or 3STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
About This Section


 Gene Network CentralTM Interacting Genes and Proteins Network for  YEATS4 


5/23 Interacting proteins for YEATS4 (O956191 ENSP000002478433) via UniProtKB, MINT, and/or STRING (see all 23 )
InteractantInteraction Details
GeneCardExternal ID(s)
TACC1O754101, ENSP000003692633EBI-399269, EBI-624237 STRING (score=.923)
SMARCB1ENSP000003408833STRING (score=.974)
NUMA1ENSP000003526753STRING (score=.972)
DMAP1ENSP000003613643STRING (score=.969)
MLLT10ENSP000003074113STRING (score=.896)
About this table

5 Gene Ontology (GO) biological process terms (links to tree view):

GO IDQualified GO termEvidencePubMed IDs
GO:0006350 transcription IEA--
GO:0007067 mitosis NAS10913114
GO:0016568 chromatin modification IEA--
GO:0040008 regulation of growth IEA--
GO:0045893 positive regulation of transcription, DNA-dependent NAS10913114
About this table
(Chemical Compounds according to UniProtKB, Enzo Life Sciences, Sigma-Aldrich, Tocris Bioscience, and/or Novoseek and Drugs according to Enzo Life Sciences and/or PharmGKB)
About This Section

Browse drugs & compounds from Enzo Life Sciences
Browse Small Molecules at Sigma-Aldrich

Browse Tocris compounds for YEATS4

(GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 219 Homo sapiens; Jun 2 2009) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView,
non coding RNAs according to RNAdb,
ESTs according to GeneTide,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from Invitrogen, Millipore, and/or Abnova,
siRNAs from Applied Biosystems, Sigma-Aldrich,
shRNA from Sigma-Aldrich, OriGene,
Tagged/untagged cDNA clones from OriGene,
Expression Assays from Applied Biosystems)
About This Section

Inhib.
RNA:
Invitrogen RNAi Products for gene knock-down (YEATS4)
Browse for Gene Knock-down Tools from Millipore
Abnova Chimera RNAi Products for Gene knock-down (YEATS4)
              OriGene 29mer shRNA kit in GFP-retroviral vector: NM_006530

              Sigma-Aldrich siRNA for YEATS4  
                     Sigma-Aldrich shRNA for YEATS4  
                     Explore Sigma-Aldrich super-pooled esiRNAs  

Applied Biosystems Silencer® siRNAs: 

NM_006530  

REFSEQ mRNAs for YEATS4 gene: 

NM_006530.2   

Applied Biosystems TaqMan ® Gene Expression Assays: 

NM_006530  

              OriGene GFP tagged cDNA clone in CMV expression vector: NM_006530
                                 Myc/DDK tagged cDNA clone in CMV expression vector: NM_006530
                                 untagged cDNA clones in CMV expression vector (see all 2): NM_006530 

Additional cDNA sequence: 

AJ245746.1 AK001413.1 BC000994.2 BX640958.1 U61384.1 

6 DOTS entries:

DT.414973  DT.99982350  DT.100782453  DT.95169503  DT.100023404  DT.121125477 

6 AceView cDNA sequences:

AK001413 NM_006530 U61384 BC000994 BX640958 AJ245746 

highest scoring ESTs for YEATS4:

AA507602 AA835883 AJ245746 BC000994 BG193950 BG206291 BG209931 U61384 Z78373 AA427613 

Unigene Cluster for YEATS4:

YEATS domain containing 4
Hs.4029  [show with all ESTs]
Unigene Representative Sequence: BX640958


GeneLoc Exon Structure

5 Alternative Splicing Database (ASD) splice patterns (SP) for YEATS4

ExUns: 1a · 1b · 1c ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9a · 9b
SP1:                    -           -                                       
SP2:                    -                                                   
SP3:                                -                                       
SP4:                    -           -     -     -                           
SP5:                                -     -     -                           

About this scheme

ECgene alternative splicing isoforms for YEATS4

1 Ensembl transcript including schematic representation:
ENST00000247843  
(Experimental results according to 1GeneNote and GNF BioGPS,
probe sets-to-genes annotations according to 2GeneAnnot , 3GeneTide , Sets of similar genes according to GeneDecks, Electronic Northern calculations according to data from UniGene (Build 219 Homo sapiens), SAGE tags according to CGAP, plus additional links to SOURCE, and/or GNF BioGPS, and/or EXPOLDB, and/or UniProtKB,
Expression Assays from Applied Biosystems )
About This Section

YEATS4 expression in normal and diseased human tissues

 Applied Biosystems TaqMan ® Gene Expression Assays for YEATS4

1 / 2 / 3

3 probe-sets matching YEATS4 gene


Affymetrix
probe-set
Array  GeneAnnot data GeneNote data GeneTide data
# genes Sensitivity Specificity Correlation Length Gb_Accession Consensus Uniqueness Score Rank
64121_at2, 3 U95-C 1 1.00 1.00 1.00 1.00 Z78373 0.80 1.00 0.91 1

218911_at2, 3 U133-A 1 1.00 1.00 -- -- NM_006530 0.60 1.00 0.82 1

218911_at2 U133Plus2 1 1.00 1.00 -- -- -- -- -- -- --
GeneDecks  YEATS4 for binary patterns associated with the probe-sets selected above  
About GeneDecksing
About this table    
Data from (Publications) and GNF BioGPS
    About these images
About these images

CGAP SAGE TAG: AATTTCTTAG

SOURCE GeneReport for Unigene cluster: Hs.4029

UniProtKB/Swiss-Prot: YETS4_HUMAN, O95619
Tissue specificity: Expressed in brain, heart, kidney, liver, lung, pancreas, placenta and skeletal
muscle

(Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD and/or 5MGI Jun 06 2009, with possible further links to Flybase and/or WormBase, Gene Trees according to Ensembl)
About This Section


Orthologs for YEATS4 gene from 5/19 species (see all 19 )
Organism Gene Locus Description Human
Similarity
NCBI accessions
dog
(Canis familiaris)
YEATS41   -- YEATS domain containing 4 95.52(n)
99.1(a)
474443  XM_531673.2  XP_531673.2 
chimpanzee
(Pan troglodytes)
YEATS41   -- YEATS domain containing 4 99.85(n)
100(a)
452069  XM_001155404.1  XP_001155404.1 
cow
(Bos taurus)
YEATS41   -- YEATS domain containing 4 95.45(n)
99.12(a)
615330  NM_001076365.1  NP_001069833.1 
rat
(Rattus norvegicus)
Yeats41   -- YEATS domain containing 4 91.33(n)
98.65(a)
299810  XM_216890.3  XP_216890.2 
mouse
(Mus musculus)
Yeats41, 5 105
YEATS domain containing 41, 5 88.55(n)1
99.56(a)1
640501  NM_026570.21  NP_080846.11 
 AA0517455  AA0868735  (see all 15)
About this table        Species with no ortholog for YEATS4

ENSEMBL Gene Tree for YEATS4
(Paralogs according to 1HomoloGene
and 2Ensembl, Pseudogenes according to 3Pseudogene.org)
About This Section

Paralogs for YEATS4 gene
YEATS22  

(According to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, and UniProtKB, Linkage Disequilibrium by HapMap, Genotyping Reagents from Applied Biosystems)
About This Section


10/275 NCBI SNPs in YEATS4 are shown (see all 275 )
(Click for Applied Biosystems TaqMan ® Genotyping Assay)  (see all 99)
ABGenomic DataTranscription DataAllele Frequencies
SNP IDValidChr 12 posSequenceRecsAA
Chg
TypeMoreRecsAllele
freq
PopTotal
sample
More
------------
rs26178351,2
A,C,F,H,O68039687(+) tcctGC/AACTGG 1 -- ng514Minor allele frequency- A:0.45EU EA WA 388
rs5894481,2
A,C,F,H68038467(+) CAAGCA/GTAGTA 1 -- ng514Minor allele frequency- G:0.45EU EA WA 416
rs26178341,2
A,C,F,H68039632(+) actttT/Ctgaag 1 -- ng51 tfbs34Minor allele frequency- C:0.46EU EA WA 410
rs6226561,2
A,C,F68039862(+) GTTGAT/CGGTTA 1 -- ut5116Minor allele frequency- C:0.45EA NA MN EU WA 2048
rs22490931,2
A,C,O68039779(-) ACGGCC/GGCACC 1 -- ng510--------
rs23062041,2
C,F,H68039797(-) GCCGCG/TAAAAG 1 -- ng51 trp34Minor allele frequency- T:0.17EU EA WA 396
rs3151111,2
A,C,F68070962(-) TTCTAT/CATGCG 1 -- ng315Minor allele frequency- C:0.49MN NA EA 546
--
rs5884931,2
A,C,F68038253(+) AAAAAG/ATATTT 1 -- ng513Minor allele frequency- A:0.44NA EA 220
--
rs71362381,2
A,C68038776(+) gtctcG/Tatctc 1 -- ng510--------
--
rs5233981,2
A,C68039042(+) tcaatC/Tccatc 1 -- ng510--------
About this table

HapMap Linkage Disequilibrium images for YEATS4 (up to first 250kb)

(in which this Gene is Involved, According to OMIM, UniProtKB, Novoseek, PharmGKB, Genatlas, GeneTests, Blood group antigen gene mutations by BGMUT, HGMD, GAD, HuGE Navigator, BCGD, and/or TGDB.)
About This Section

OMIM: 602116

2 Novoseek disease relationships for YEATS4 gene

Disease   Score   Articles   PubMed IDs for Articles with Shared Sentences (# sentences)
glioma 43.85 2 11903063 (1), 9302258 (1)
tumors 0.00 7 16705155 (5), 9302258 (1)
About this table

Human Genome Epidemiology Navigator: YEATS4 (1 document)

(Possibly Related Articles in Doctor's Guide)
About This Section

  --

(in PubMed. Associations of this gene to articles via 1Novoseek, 2HGNC, 3Entrez Gene, 4UniProtKB/Swiss-Prot, 5UniProtKB/TrEMBL, 6GAD, and/or 7PharmGKB)
About This Section

10/20 PubMed articles for YEATS4 gene (see all 20 ):
(in PubMed, OMIM, and NCBI Bookshelf)
About This Section

 ANDOR
Aliases
Free Text  

  Query String
PubMed
OMIM
NCBI Bookshelf
  (Note: In FireFox, select the above section and copy using Ctrl-C)
(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, and/or H-InvDB)
About This Section

Entrez Gene: 8089 HGNC: 24859 AceView: YEATS4 Ensembl:ENSG00000127337 euGenes: HUgn8089
ECgene: YEATS4 H-InvDB: YEATS4
(According to HUGE)
About This Section

  --
(According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section

NameDescription
ATLAS Chromosomes in Cancer entry for YEATS4 Genetics and Cytogenetics in Oncology and Haematology
(Available from WIS Yeda, Salk, Tufts)
About This Section

  --
(Reagents available from Applied Biosystems, Antibodies and assays by Cell Signaling Technology, Abcam, Novus Biologicals,
Sigma-Aldrich, R&D Systems, Millipore, Abnova, and/or Invitrogen, Clones available from OriGene,and/or Invitrogen, Drugs and/or compounds by Sigma-Aldrich,
Enzo Life Sciences, and/or Tocris Bioscience)
About This Section



Products for YEATS4:
 TaqMan ® Gene Expression Assays
 TaqMan ® Genotyping Assays
  Free SNP selection tool



  Invitrogen iPath Pathways  Invitrogen BLOCK-iT™ RNAi
  Invitrogen Antibodies  Invitrogen Assays
  Invitrogen Clones  Invitrogen Q-PCR Products
  Invitrogen Human Recombinant Kinases  Invitrogen Custom Antibody and Peptide Service
  Invitrogen Proteins / Assays / Screening Services  Search Invitrogen catalog for YEATS4-related products

 Millipore Custom Antibody & Bulk Services
 Millipore Preclinical / Clinical Development Services
 Millipore Immunoassay Services
 Millipore Target Screening & Profiling Services


 Predesigned and custom siRNAs for YEATS4 Antibodies for YEATS4
 Explore super-pooled esiRNAs Browse proteins at Sigma-Aldrich
 Lentivirus-delivered shRNAs for YEATS4 Browse small molecules at Sigma-Aldrich
 "Your Favorite Gene" Pathwaysfeedback


  
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 Recombinant & Natural Proteins  

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 Antibodies (YEATS4)
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 Custom Service for Rabbit Pab from Full-length Protein
  
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 Recombinant Proteins
(GAS41)
 Antibodies (GAS41)
 Tagged/untagged cDNA clones
 Validated SYBR primer pairs
 Purified proteins from HEK293T cells
 Western blot validated antibodies
 shRNA in GFP-retroviral vector
 Search Tocris compounds for YEATS4




 Search www.enzolifesicences.com for proteins, assays, substrates, inhibitors & antibodies
 Antibodies for YEATS4

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