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Aliases for YEATS2 Gene

Aliases for YEATS2 Gene

  • YEATS Domain Containing 2 2 3 5
  • KIAA1197 4

External Ids for YEATS2 Gene

Previous GeneCards Identifiers for YEATS2 Gene

  • GC03P184899
  • GC03P183416
  • GC03P180824

Summaries for YEATS2 Gene

Entrez Gene Summary for YEATS2 Gene

  • Summary: The protein encoded by this gene is a scaffolding subunit of the ATAC complex, which is a complex with acetyltransferase activity on histones H3 and H4. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, May 2017]

GeneCards Summary for YEATS2 Gene

YEATS2 (YEATS Domain Containing 2) is a Protein Coding gene. Diseases associated with YEATS2 include Enchondromatosis, Multiple, Ollier Type. Among its related pathways are Chromatin organization. GO annotations related to this gene include TBP-class protein binding. An important paralog of this gene is YEATS4.

UniProtKB/Swiss-Prot for YEATS2 Gene

  • Component of the ATAC complex, a complex with histone acetyltransferase activity on histones H3 and H4.

Additional gene information for YEATS2 Gene

No data available for CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for YEATS2 Gene

Genomics for YEATS2 Gene

Regulatory Elements for YEATS2 Gene

Enhancers for YEATS2 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH03H184015 1.4 Ensembl ENCODE 22.5 +319.2 319199 3.6 HDGF PKNOX1 ARNT ARID4B SIN3A FEZF1 ZNF2 YY1 ZNF766 ZNF207 YEATS2 HTR3D ENSG00000271682 ABCC5 RPS3P3 HTR3C EIF2B5 AP2M1 ALG3 CAMK2N2
GH03H183532 1.9 FANTOM5 Ensembl ENCODE dbSUPER 10.1 -164.4 -164385 2.7 HDGF PKNOX1 ATF1 ARNT ZNF766 FOS ATF7 RUNX3 NCOA1 JUNB KLHL6 ENSG00000251730 ENSG00000199363 SNORA63D ENSG00000253092 LINC00888 EIF4G1 YEATS2 B3GNT5 HTR3D
GH03H183536 1.8 FANTOM5 Ensembl ENCODE dbSUPER 10.5 -160.4 -160410 2.7 HDGF BATF TCF12 GATA2 ZNF143 ATF7 ETV6 RUNX3 CREM IKZF2 KLHL6 KLHL24 B3GNT5 YEATS2 MCF2L2 KLHL6-AS1 ENSG00000271682
GH03H183539 1.7 FANTOM5 Ensembl ENCODE dbSUPER 10.4 -156.6 -156569 3 HDGF BMI1 BATF ZNF366 ATF7 ETV6 RUNX3 CREM IKZF2 SMARCA5 KLHL6 B3GNT5 KLHL24 YEATS2 MCF2L2 KLHL6-AS1 ENSG00000271682
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around YEATS2 on UCSC Golden Path with GeneCards custom track

Promoters for YEATS2 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000162838 696 2201 ATF1 SIN3A DMAP1 ZBTB7B ZNF766 GLIS2 ELK1 ZNF143 ZNF207 ATF7

Genomic Locations for YEATS2 Gene

Genomic Locations for YEATS2 Gene
114,822 bases
Plus strand

Genomic View for YEATS2 Gene

Genes around YEATS2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
YEATS2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for YEATS2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for YEATS2 Gene

Proteins for YEATS2 Gene

  • Protein details for YEATS2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    YEATS domain-containing protein 2
    Protein Accession:
    Secondary Accessions:
    • A7E2B9
    • D3DNS9
    • Q641P6
    • Q9NW96

    Protein attributes for YEATS2 Gene

    1422 amino acids
    Molecular mass:
    150782 Da
    Quaternary structure:
    • Component of the ADA2A-containing complex (ATAC), composed of KAT14, KAT2A, TADA2L, TADA3L, ZZ3, MBIP, WDR5, YEATS2, CCDC101 and DR1.
    • Sequence=BAA86511.1; Type=Erroneous initiation; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for YEATS2 Gene

neXtProt entry for YEATS2 Gene

Post-translational modifications for YEATS2 Gene

  • Ubiquitination at Lys719
  • Modification sites at PhosphoSitePlus

No data available for DME Specific Peptides for YEATS2 Gene

Domains & Families for YEATS2 Gene

Gene Families for YEATS2 Gene

Protein Domains for YEATS2 Gene


Suggested Antigen Peptide Sequences for YEATS2 Gene

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with YEATS2: view

No data available for UniProtKB/Swiss-Prot for YEATS2 Gene

Function for YEATS2 Gene

Molecular function for YEATS2 Gene

UniProtKB/Swiss-Prot Function:
Component of the ATAC complex, a complex with histone acetyltransferase activity on histones H3 and H4.

Gene Ontology (GO) - Molecular Function for YEATS2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 18838386
GO:0017025 TBP-class protein binding IPI 18838386
GO:0042393 histone binding IDA 27103431
genes like me logo Genes that share ontologies with YEATS2: view
genes like me logo Genes that share phenotypes with YEATS2: view

Animal Model Products

miRNA for YEATS2 Gene

Clone Products

No data available for Enzyme Numbers (IUBMB) , Phenotypes From GWAS Catalog , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for YEATS2 Gene

Localization for YEATS2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for YEATS2 Gene

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for YEATS2 gene
Compartment Confidence
nucleus 5
cytoskeleton 2
cytosol 2

Subcellular locations from the

Human Protein Atlas (HPA)

Gene Ontology (GO) - Cellular Components for YEATS2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IEA --
GO:0005671 Ada2/Gcn5/Ada3 transcription activator complex IEA,IDA 18838386
GO:0072686 mitotic spindle IEA --
genes like me logo Genes that share ontologies with YEATS2: view

Pathways & Interactions for YEATS2 Gene

genes like me logo Genes that share pathways with YEATS2: view

Pathways by source for YEATS2 Gene

Gene Ontology (GO) - Biological Process for YEATS2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000122 negative regulation of transcription from RNA polymerase II promoter IDA 18838386
GO:0006355 regulation of transcription, DNA-templated IEA --
GO:0043966 histone H3 acetylation IDA 18838386
GO:0045892 negative regulation of transcription, DNA-templated IDA 18838386
genes like me logo Genes that share ontologies with YEATS2: view

No data available for SIGNOR curated interactions for YEATS2 Gene

Drugs & Compounds for YEATS2 Gene

No Compound Related Data Available

Transcripts for YEATS2 Gene

Unigene Clusters for YEATS2 Gene

YEATS domain containing 2:
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for YEATS2 Gene

No ASD Table

Relevant External Links for YEATS2 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for YEATS2 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for YEATS2 Gene

Protein differential expression in normal tissues from HIPED for YEATS2 Gene

This gene is overexpressed in Breast (56.5) and Heart (6.4).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for YEATS2 Gene

NURSA nuclear receptor signaling pathways regulating expression of YEATS2 Gene:


SOURCE GeneReport for Unigene cluster for YEATS2 Gene:


Evidence on tissue expression from TISSUES for YEATS2 Gene

  • Nervous system(4.9)
  • Liver(4.5)
  • Lung(4.4)
  • Skin(2.8)
  • Eye(2.3)
  • Intestine(2.3)
  • Muscle(2.2)
genes like me logo Genes that share expression patterns with YEATS2: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for YEATS2 Gene

Orthologs for YEATS2 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for YEATS2 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia YEATS2 33 34
  • 98.56 (n)
(Canis familiaris)
Mammalia YEATS2 33 34
  • 91.08 (n)
(Bos Taurus)
Mammalia YEATS2 33 34
  • 91.01 (n)
(Ornithorhynchus anatinus)
Mammalia -- 34
  • 88 (a)
-- 34
  • 82 (a)
-- 34
  • 79 (a)
(Mus musculus)
Mammalia Yeats2 33 16 34
  • 84.86 (n)
(Rattus norvegicus)
Mammalia Yeats2 33
  • 83.62 (n)
(Monodelphis domestica)
Mammalia YEATS2 34
  • 82 (a)
(Gallus gallus)
Aves YEATS2 33 34
  • 73.62 (n)
(Anolis carolinensis)
Reptilia YEATS2 34
  • 72 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia yeats2 33
  • 65.44 (n)
Str.10908 33
African clawed frog
(Xenopus laevis)
Amphibia MGC68945 33
(Danio rerio)
Actinopterygii yeats2 33 34
  • 61.17 (n)
fruit fly
(Drosophila melanogaster)
Insecta D12 34
  • 11 (a)
(Caenorhabditis elegans)
Secernentea Y105E8B.7 34
  • 16 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes YAF9 34
  • 25 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 34
  • 73 (a)
Species where no ortholog for YEATS2 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for YEATS2 Gene

Gene Tree for YEATS2 (if available)
Gene Tree for YEATS2 (if available)

Paralogs for YEATS2 Gene

Paralogs for YEATS2 Gene

(1) SIMAP similar genes for YEATS2 Gene using alignment to 3 proteins:

genes like me logo Genes that share paralogs with YEATS2: view

Variants for YEATS2 Gene

Sequence variations from dbSNP and Humsavar for YEATS2 Gene

SNP ID Clin Chr 03 pos Sequence Context AA Info Type
rs376025260 Uncertain significance 183,797,956(+) CAGTC(C/T)GCAGC nc-transcript-variant, reference, missense
rs1000001408 -- 183,756,320(+) CCATG(G/T)ATAAG intron-variant
rs1000023804 -- 183,696,417(+) CCTTT(C/T)TTAGT upstream-variant-2KB
rs1000032770 -- 183,734,643(+) AACAT(A/G/T)CAGGA intron-variant
rs1000051857 -- 183,696,807(+) CGCCT(A/G)TAATC upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for YEATS2 Gene

Variant ID Type Subtype PubMed ID
nsv998955 CNV gain 25217958
nsv592656 CNV gain 21841781
nsv507144 OTHER sequence alteration 20534489
nsv478634 CNV novel sequence insertion 20440878
nsv475272 CNV novel sequence insertion 20440878
esv2726292 CNV deletion 23290073

Variation tolerance for YEATS2 Gene

Residual Variation Intolerance Score: 33.4% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 13.87; 95.89% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for YEATS2 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for YEATS2 Gene

Disorders for YEATS2 Gene

MalaCards: The human disease database

(1) MalaCards diseases for YEATS2 Gene - From: DISEASES

Disorder Aliases PubMed IDs
enchondromatosis, multiple, ollier type
  • hereditary multiple exostoses
- elite association - COSMIC cancer census association via MalaCards

Relevant External Links for YEATS2

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
genes like me logo Genes that share disorders with YEATS2: view

No data available for UniProtKB/Swiss-Prot and Genatlas for YEATS2 Gene

Publications for YEATS2 Gene

  1. Prediction of the coding sequences of unidentified human genes. XV. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro. (PMID: 10574462) Nagase T … Ohara O (DNA research : an international journal for rapid publication of reports on genes and genomes 1999) 2 3 4 60
  2. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose JE … Uhl GR (Molecular medicine (Cambridge, Mass.) 2010) 3 45 60
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 60
  4. Architecture of the human interactome defines protein communities and disease networks. (PMID: 28514442) Huttlin EL … Harper JW (Nature 2017) 3 60
  5. Site-specific mapping of the human SUMO proteome reveals co-modification with phosphorylation. (PMID: 28112733) Hendriks IA … Nielsen ML (Nature structural & molecular biology 2017) 4 60

Products for YEATS2 Gene

Sources for YEATS2 Gene

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