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YEATS2 Gene

protein-coding   GIFtS: 46

GC03P184899
YEATS domain containing 2
Symbol approved by the HUGO Gene Nomenclature Committee (HGNC) database
Services    
(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc , and/or 7Ensembl, 8miRBase)
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Aliases
FLJ10201 1, 2
FLJ12841 1, 2
FLJ13308 1, 2
KIAA1197 1, 2, 3
Descriptions
YEATS domain containing 2 2
External Ids
HGNC: 254891
Entrez Gene: 556892
UniProtKB: Q9ULM33
Ensembl: ENSG000001638727
Search outside databases for aliases for YEATS2 gene

(According to Entrez Gene, Wikipedia's Gene Wiki,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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  --
(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 36),
and/or miRBase,
Genomic Views according to UCSC and Ensembl, Transcription factor binding sites according to SABiosciences)
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Genomic View:
UCSC Golden Path with GeneCards custom track

 Transcription factor binding sites upstream to the YEATS2 gene  

Entrez Gene cytogenetic band: 3q27.1   Ensembl cytogenetic band:  3q27.1   HGNC cytogenetic band: 3q27.3

YEATS2 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)

GeneLoc gene densities for chromosome 3         GeneLoc Exon Structure

GeneLoc location for GC03P184899:     (about GC identifiers)

Start:
184,898,300 bp from pter
End:
185,013,102 bp from pter
Size:
114,803 bases
Orientation:
plus strand
RefSeq DNA sequence:
NC_000003.10  NT_005612.15  
(According to 1UniProtKB, and/or Ensembl, Phosphorylation sites according to 2Phosphosite, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Enzo Life Sciences, Abnova, OriGene and/or, Abcam,
Biochemical Assays by Invitrogen, Millipore, R&D Systems, Cell Signaling Technology, and/or Enzo Life Sciences, Ontologies according to Gene Ontology Consortium 01 Apr 2009 and Entrez Gene, Antibodies by Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Cell Signaling Technology, Abcam, Abnova, and/or Novus Biologicals)
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UniProtKB/Swiss-Prot: YETS2_HUMAN, Q9ULM3 (See protein sequence)
Recommended Name: YEATS domain-containing protein 2  
Size: 1422 amino acids; 150782 Da
Subcellular location: Nucleus (Probable)
Secondary accessions: A7E2B9 Q641P6 Q9NW96

Post-translational modifications:

  • Phosphorylated upon DNA damage, probably by ATM or ATR1
  • View phosphorylation sites using PhosphoSite2


  • REFSEQ proteins: NP_060493.3  

    ENSEMBL proteins: 
    ENSP00000306983 ENSP00000273660 


    Human Recombinant Proteins 
    Browse Drug Discovery Central at Invitrogen for human recombinant proteins
    Browse Purified and Recombinant Proteins at Millipore
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    Browse Abcam for Recombinant Proteins
    Browse Abnova for Human Recombinant Proteins
                    Browse Origene for full length recombinant human proteins expressed in human HEK293 cells 

    1 Gene Ontology (GO) cellular component term (links to tree view):

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634 nucleus IEA--
    About this table

    Antibodies for YEATS2: 
    Browse Antibodies Central at Invitrogen
    Browse Millipore's Extensive Line of Mono- and Polyclonal Antibodies
    Browse Antibodies at Sigma-Aldrich
    Browse R&D Systems for Antibodies
    Search for antibodies at Abcam and the World's Antibody Gateway (free search engine of over 150 antibody companies)
    Browse Abnova for Monoclonal and Polyclonal Antibodies
    Search Novus for antibodies for YEATS2

    Assays for YEATS2: 
    Browse Invitrogen for biochemical assays
    Browse Kits and Assays available from Millipore
    Browse R&D Systems for biochemical assays
    Browse biochemical assays available from Enzo Life Sciences

    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    1 InterPro domain/family:
     IPR005033 YEATS


       GeneDecks  YEATS2 for the domains selected above  
    About GeneDecksing

    Graphical View of Domain Structure for InterPro Entry Q9ULM3

    ProtoNet protein and cluster: Q9ULM3

    1 Blocks protein family: IPB005033 YEATS family

    UniProtKB/Swiss-Prot: YETS2_HUMAN, Q9ULM3
    Similarity: Contains 1 YEATS domain

    (According to MGI Jun 06 2009, UniProtKB, IUBMB,and/or Genatlas,
    shRNA from OriGene, Sigma-Aldrich, RNAi from Sigma-Aldrich,
    RNAi Products, Clones, and Q-PCR Products from Invitrogen, Millipore, OriGene, and/or Abnova, siRNAs from Applied Biosystems, SYBR primers from OriGene, Cell-based Assays from Millipore, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
    About This Section

    Inhib.
    RNA:
    Invitrogen RNAi Products for gene knock-down (YEATS2)
    Browse for Gene Knock-down Tools from Millipore
    Browse Abnova for Chimera RNAi Products
                  OriGene 29mer shRNA kit in GFP-retroviral vector: NM_018023

                  Applied Biosystems Silencer® siRNAs for YEATS2

                  Sigma-Aldrich siRNA for YEATS2  
                         Sigma-Aldrich shRNA for YEATS2  
                         Explore Sigma-Aldrich super-pooled esiRNAs  

    Clones:Browse Clone Ranger at Invitrogen for clones
    Browse Clones for the Expression of Recombinant Proteins Available from Millipore
                  OriGene GFP tagged cDNA clone in CMV expression vector: NM_018023
                                     Myc/DDK tagged cDNA clone in CMV expression vector: NM_018023
                                     untagged cDNA clones in CMV expression vector (see all 2): AK022903 

    Primers: Browse Quantitative PCR Central at Invitrogen for Q-PCR LUX™ Primers
                  OriGene genome-wide validated SYBR primer pairs: NM_018023

    (Pathways according to Invitrogen (maps by GeneGo), Millipore, Cell Signaling Technology, Sigma-Aldrich, KEGG and/or UniProtKB,
    Sets of similar genes according to GeneDecks, Proteins Network according to SABiosciences, Interactions according to 1UniProtKB, 2MINT, and/or 3STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
    About This Section



    1 Interacting protein for YEATS2 (ENSP000003069833) via UniProtKB, MINT, and/or STRING
    InteractantInteraction Details
    GeneCardExternal ID(s)
    POLE4ENSP000002336993STRING (score=.704)
    About this table

    1 Gene Ontology (GO) biological process term (links to tree view):

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006355 regulation of transcription, DNA-dependent IEA--
    About this table
    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, Sigma-Aldrich, Tocris Bioscience, and/or Novoseek and Drugs according to Enzo Life Sciences and/or PharmGKB)
    About This Section

    Browse drugs & compounds from Enzo Life Sciences
    Browse Small Molecules at Sigma-Aldrich

    Browse Tocris compounds for YEATS2

    (GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 219 Homo sapiens; Jun 2 2009) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView,
    non coding RNAs according to RNAdb,
    ESTs according to GeneTide,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from Invitrogen, Millipore, and/or Abnova,
    siRNAs from Applied Biosystems, Sigma-Aldrich,
    shRNA from Sigma-Aldrich, OriGene,
    Tagged/untagged cDNA clones from OriGene,
    Expression Assays from Applied Biosystems)
    About This Section

    Inhib.
    RNA:
    Invitrogen RNAi Products for gene knock-down (YEATS2)
    Browse for Gene Knock-down Tools from Millipore
    Browse Abnova for Chimera RNAi Products
                  OriGene 29mer shRNA kit in GFP-retroviral vector: NM_018023

                  Sigma-Aldrich siRNA for YEATS2  
                         Sigma-Aldrich shRNA for YEATS2  
                         Explore Sigma-Aldrich super-pooled esiRNAs  

    Applied Biosystems Silencer® siRNAs: 

    NM_018023  

    REFSEQ mRNAs for YEATS2 gene: 

    NM_018023.3   

    Applied Biosystems TaqMan ® Gene Expression Assays: 

    NM_018023  

                  OriGene GFP tagged cDNA clone in CMV expression vector: NM_018023
                                     Myc/DDK tagged cDNA clone in CMV expression vector: NM_018023
                                     untagged cDNA clones in CMV expression vector (see all 2): AK022903 

    Additional cDNA sequence: 

    AB033023.1 AK022903.1 AK023370.1 AK090720.1 AK091654.1 BC009276.2 BC032368.1 BC043393.1 
    BC082270.1 BC150273.1 CR605431.1 

    13 DOTS entries:

    DT.111774  DT.95185210  DT.92445435  DT.99995340  DT.100789471  DT.100732010  DT.95327588  DT.120895146 
    DT.92445439  DT.99926964  DT.100789469  DT.102821182  DT.97846459 

    24/228 AceView cDNA sequences (see all 228 ):

    BQ056665 AA630045 BM551543 BC043393 BM551754 CR605431 CD300788 BU543752 
    AW875926 CB216757 BQ183768 BQ058052 CB306435 BM723029 BU855223 BU739177 
    NM_018023 AB033023 BQ432061 BM763112 AJ710085 AI968000 BG059827 AK091654 

    highest scoring ESTs for YEATS2:

    AA313774 AB033023 AK022903 AL597488 AU117885 AU125187 AW277036 BC009276 BE003882 BE019159 

    Unigene Cluster for YEATS2:

    YEATS domain containing 2
    Hs.632575  [show with all ESTs]
    Unigene Representative Sequence: BC150273


    GeneLoc Exon Structure

    2 Ensembl transcripts including schematic representations:
    ENST00000305135  ENST00000273660  
    (Experimental results according to 1GeneNote and GNF BioGPS,
    probe sets-to-genes annotations according to 2GeneAnnot , 3GeneTide , Sets of similar genes according to GeneDecks, Electronic Northern calculations according to data from UniGene (Build 219 Homo sapiens), SAGE tags according to CGAP, plus additional links to SOURCE, and/or GNF BioGPS, and/or EXPOLDB, and/or UniProtKB,
    Expression Assays from Applied Biosystems )
    About This Section

    YEATS2 expression in normal and diseased human tissues

     Applied Biosystems TaqMan ® Gene Expression Assays for YEATS2

    1 / 2 / 3

    4 probe-sets matching YEATS2 gene


    Affymetrix
    probe-set
    Array  GeneAnnot data GeneNote data GeneTide data
    # genes Sensitivity Specificity Correlation Length Gb_Accession Consensus Uniqueness Score Rank
    54098_at2, 3 U95-B 1 1.00 1.00 1.00 1.00 AI816255 0.60 1.00 0.82 1

    221203_s_at2, 3 U133-A 1 1.00 1.00 -- -- NM_018023 0.60 1.00 0.82 1

    221203_s_at2 U133Plus2 1 1.00 1.00 -- -- -- -- -- -- --

    1557047_at2 U133Plus2 1 1.00 1.00 -- -- -- -- -- -- --
    GeneDecks  YEATS2 for binary patterns associated with the probe-sets selected above  
    About GeneDecksing
    About this table    
    Data from (Publications) and GNF BioGPS
        About these images
    About these images

    CGAP SAGE TAG: GCTACACCCC

    SOURCE GeneReport for Unigene cluster: Hs.632575
    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD and/or 5MGI Jun 06 2009, with possible further links to Flybase and/or WormBase, Gene Trees according to Ensembl)
    About This Section


    Orthologs for YEATS2 gene from 5/9 species (see all 9 )
    Organism Gene Locus Description Human
    Similarity
    NCBI accessions
    dog
    (Canis familiaris)
    YEATS21   -- YEATS domain containing 2 91.22(n)
    94.39(a)
    488099  XM_545223.2  XP_545223.2 
    chimpanzee
    (Pan troglodytes)
    YEATS21   -- YEATS domain containing 2 99.29(n)
    99.44(a)
    460875  XM_001135033.1  XP_001135033.1 
    cow
    (Bos taurus)
    YEATS21   -- YEATS domain containing 2 91.22(n)
    94.11(a)
    514192  XM_592001.3  XP_592001.3 
    rat
    (Rattus norvegicus)
    Yeats21   -- YEATS domain containing 2 83.88(n)
    86.97(a)
    498112  XM_573318.2  XP_573318.2 
    mouse
    (Mus musculus)
    Yeats21, 5 165
    YEATS domain containing 21, 5 84.86(n)1
    87.06(a)1
    2081461  NM_001033237.11  NP_001028409.11 
     AA1381435  AK1224635  (see all 14)
    About this table        Species with no ortholog for YEATS2

    ENSEMBL Gene Tree for YEATS2
    (Paralogs according to 1HomoloGene
    and 2Ensembl, Pseudogenes according to 3Pseudogene.org)
    About This Section

    Paralogs for YEATS2 gene
    YEATS42  

    (According to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, and UniProtKB, Linkage Disequilibrium by HapMap, Genotyping Reagents from Applied Biosystems)
    About This Section


    10/647 NCBI SNPs in YEATS2 are shown (see all 647 )
    (Click for Applied Biosystems TaqMan ® Genotyping Assay)  (see all 167)
    ABGenomic DataTranscription DataAllele Frequencies
    SNP IDValidChr 3 posSequenceRecsAA
    Chg
    TypeMoreRecsAllele
    freq
    PopTotal
    sample
    More
    ------------
    rs2630241,2
    A,C,F,H,O185011136(-) TTCCCA/GAGCAG 1 -- ut31 ese38Minor allele frequency- G:0.47EU EA WA NA 2036
    rs2629931,2
    A,C,F,H184959379(-) GGAGAC/TCTGAG 1 V/I mis1 ese39Minor allele frequency- T:0.45MN EU EA WA 1016
    rs32110951,2
    C,F,H184991344(+) CAGCAG/TCAAGT 1 Q/H mis1 ese313Minor allele frequency- T:0.01MN EU EA WA 1416
    rs168580331,2
    C,F,H184924913(+) CTAGAA/GTTACT 1 I/V mis1 ese312Minor allele frequency- G:0.07NA EU EA WA 1050
    --
    rs98364891,2
    A,C,F185013212(+) CCTCTA/GCTTCT 1 -- ng313Minor allele frequency- G:0.49NA 142
    --
    rs109371491,2
    A,F,H184897266(+) ATTAgG/Cctggg 1 -- ng513Minor allele frequency- C:0.36EA WA 298
    --
    rs98743461,2
    C,F,H185013025(+) TCCACA/C/GTGTGT 1 -- ut31 ese37EU EA WA NA 562
    rs98169731,2
    H184896810(+) GACCTC/GTGACC 1 -- ng51 tfbs34Minor allele frequency- G:0.00EU EA WA 396
    rs37365351,2
    A,C,F,H184915677(-) GGGTCG/AGTTTC 1 T/T syn1 ese312Minor allele frequency- A:0.31EA NA EU WA 2352
    rs340994561,2
    F184952617(-) GACTCC/TGAGGA 1 S/S syn11Minor allele frequency- T:0.04NA 70
    About this table

    HapMap Linkage Disequilibrium images for YEATS2 (up to first 250kb)

    (in which this Gene is Involved, According to OMIM, UniProtKB, PharmGKB, Genatlas, GeneTests, Blood group antigen gene mutations by BGMUT, HGMD, GAD, HuGE Navigator, BCGD, and/or TGDB.)
    About This Section

      --

    (Possibly Related Articles in Doctor's Guide)
    About This Section

      --

    (in PubMed. Associations of this gene to articles via 1Novoseek, 2HGNC, 3Entrez Gene, 4UniProtKB/Swiss-Prot, 5UniProtKB/TrEMBL, 6GAD, and/or 7PharmGKB)
    About This Section

    9 PubMed articles for YEATS2 gene:
    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section

     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)
    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, and/or H-InvDB)
    About This Section

    Entrez Gene: 55689 HGNC: 25489 AceView: YEATS2 Ensembl:ENSG00000163872 euGenes: HUgn55689
    ECgene: YEATS2 H-InvDB: YEATS2
    (According to HUGE)
    About This Section

    HUGE: KIAA1197
    (According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section

      --
    (Available from WIS Yeda, Salk, Tufts)
    About This Section

      --
    (Reagents available from Applied Biosystems, Antibodies and assays by Cell Signaling Technology, Abcam, Novus Biologicals,
    Sigma-Aldrich, R&D Systems, Millipore, Abnova, and/or Invitrogen, Clones available from OriGene,and/or Invitrogen, Drugs and/or compounds by Sigma-Aldrich,
    Enzo Life Sciences, and/or Tocris Bioscience)
    About This Section



    Products for YEATS2:
     TaqMan ® Gene Expression Assays
     TaqMan ® Genotyping Assays
      Free SNP selection tool



      Invitrogen iPath Pathways  Invitrogen BLOCK-iT™ RNAi
      Invitrogen Antibodies  Invitrogen Assays
      Invitrogen Clones  Invitrogen Q-PCR Products
      Invitrogen Human Recombinant Kinases  Invitrogen Custom Antibody and Peptide Service
      Invitrogen Proteins / Assays / Screening Services  Search Invitrogen catalog for YEATS2-related products

     Millipore Custom Antibody & Bulk Services
     Millipore Preclinical / Clinical Development Services
     Millipore Immunoassay Services
     Millipore Target Screening & Profiling Services


     Predesigned and custom siRNAs for YEATS2 Browse antibodies at Sigma-Aldrich
     Explore super-pooled esiRNAs Browse proteins at Sigma-Aldrich
     Lentivirus-delivered shRNAs for YEATS2 Browse small molecules at Sigma-Aldrich
     "Your Favorite Gene" Pathwaysfeedback


      
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     Search www.enzolifesicences.com for proteins, assays, substrates, inhibitors & antibodies
     Search Novus for antibodies for YEATS2

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