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YEATS2 Gene

protein-coding GIFtS: 46

GC03P184899

YEATS domain containing 2
Symbol approved by the HUGO Gene Nomenclature Committee (HGNC) database

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc , and/or ⁷Ensembl, ⁸miRBase)
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Aliases
FLJ10201 ^¹, ²
FLJ12841 ^¹, ²
FLJ13308 ^¹, ²
KIAA1197 ^¹, ², ³

Descriptions
YEATS domain containing 2 ^²

External Ids
HGNC: 25489¹
Entrez Gene: 55689²
UniProtKB: Q9ULM3³
Ensembl: ENSG00000163872⁷

Search outside databases for aliases for YEATS2 gene

(According to Entrez Gene, Wikipedia's Gene Wiki,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 36),
and/or miRBase,
Genomic Views according to UCSC and Ensembl, Transcription factor binding sites according to SABiosciences)
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Genomic View:

UCSC Golden Path with GeneCards custom track

Transcription factor binding sites upstream to the YEATS2 gene

Entrez Gene cytogenetic band: 3q27.1 Ensembl cytogenetic band: 3q27.1 HGNC cytogenetic band: 3q27.3

YEATS2 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)

GeneLoc gene densities for chromosome 3 GeneLoc Exon Structure

GeneLoc location for GC03P184899: (about GC identifiers)

Start:	184,898,300 bp from pter
End:	185,013,102 bp from pter
Size:	114,803 bases
Orientation:	plus strand

RefSeq DNA sequence:

NC_000003.10 NT_005612.15

(According to ¹UniProtKB, and/or Ensembl, Phosphorylation sites according to ²Phosphosite, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Enzo Life Sciences, Abnova, OriGene and/or, Abcam,
Biochemical Assays by Invitrogen, Millipore, R&D Systems, Cell Signaling Technology, and/or Enzo Life Sciences, Ontologies according to Gene Ontology Consortium 01 Apr 2009 and Entrez Gene, Antibodies by Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Cell Signaling Technology, Abcam, Abnova, and/or Novus Biologicals)
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UniProtKB/Swiss-Prot: YETS2_HUMAN, Q9ULM3 (See protein sequence)

Recommended Name: YEATS domain-containing protein 2

Size: 1422 amino acids; 150782 Da

Subcellular location: Nucleus (Probable)

Secondary accessions: A7E2B9 Q641P6 Q9NW96

Post-translational modifications:

Phosphorylated upon DNA damage, probably by ATM or ATR¹

View phosphorylation sites using PhosphoSite²

REFSEQ proteins: NP_060493.3

ENSEMBL proteins:

ENSP00000306983 ENSP00000273660

Human Recombinant Proteins

	Browse Drug Discovery Central at Invitrogen for human recombinant proteins
	Browse Purified and Recombinant Proteins at Millipore
	Browse Human Recombinant Proteins at Sigma-Aldrich
	Browse R&D Systems for human recombinant proteins
	Browse recombinant and purified proteins available from Enzo Life Sciences
	Browse Abcam for Recombinant Proteins
	Browse Abnova for Human Recombinant Proteins

Browse Origene for full length recombinant human proteins expressed in human HEK293 cells

1 Gene Ontology (GO) cellular component term (links to tree view):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005634	nucleus	IEA	--

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Antibodies for YEATS2:

	Browse Antibodies Central at Invitrogen
	Browse Millipore's Extensive Line of Mono- and Polyclonal Antibodies
	Browse Antibodies at Sigma-Aldrich
	Browse R&D Systems for Antibodies
	Search for antibodies at Abcam and the World's Antibody Gateway (free search engine of over 150 antibody companies)
	Browse Abnova for Monoclonal and Polyclonal Antibodies
	Search Novus for antibodies for YEATS2

Assays for YEATS2:

	Browse Invitrogen for biochemical assays
	Browse Kits and Assays available from Millipore
	Browse R&D Systems for biochemical assays
	Browse biochemical assays available from Enzo Life Sciences

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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Graphical View of Domain Structure for InterPro Entry Q9ULM3

ProtoNet protein and cluster: Q9ULM3

1 Blocks protein family: IPB005033 YEATS family

UniProtKB/Swiss-Prot: YETS2_HUMAN, Q9ULM3

Similarity: Contains 1 YEATS domain

(According to MGI Jun 06 2009, UniProtKB, IUBMB,and/or Genatlas,
shRNA from OriGene, Sigma-Aldrich, RNAi from Sigma-Aldrich,
RNAi Products, Clones, and Q-PCR Products from Invitrogen, Millipore, OriGene, and/or Abnova, siRNAs from Applied Biosystems, SYBR primers from OriGene, Cell-based Assays from Millipore, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
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Inhib. RNA:		Invitrogen RNAi Products for gene knock-down (YEATS2)
		Browse for Gene Knock-down Tools from Millipore
		Browse Abnova for Chimera RNAi Products

OriGene 29mer shRNA kit in GFP-retroviral vector: NM_018023

Applied Biosystems Silencer® siRNAs for YEATS2

Sigma-Aldrich siRNA for YEATS2

Sigma-Aldrich shRNA for YEATS2

Explore Sigma-Aldrich super-pooled esiRNAs

Clones:		Browse Clone Ranger at Invitrogen for clones
		Browse Clones for the Expression of Recombinant Proteins Available from Millipore

OriGene GFP tagged cDNA clone in CMV expression vector: NM_018023
Myc/DDK tagged cDNA clone in CMV expression vector: NM_018023
untagged cDNA clones in CMV expression vector (see all 2): AK022903

Primers:

Browse Quantitative PCR Central at Invitrogen for Q-PCR LUX™ Primers

OriGene genome-wide validated SYBR primer pairs: NM_018023

(Pathways according to Invitrogen (maps by GeneGo), Millipore, Cell Signaling Technology, Sigma-Aldrich, KEGG and/or UniProtKB,
Sets of similar genes according to GeneDecks, Proteins Network according to SABiosciences, Interactions according to ¹UniProtKB, ²MINT, and/or ³STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
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1 Interacting protein for YEATS2 (ENSP00000306983³) via UniProtKB, MINT, and/or STRING

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
POLE4	ENSP00000233699³	STRING (score=.704)

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1 Gene Ontology (GO) biological process term (links to tree view):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0006355	regulation of transcription, DNA-dependent	IEA	--

About this table

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, Sigma-Aldrich, Tocris Bioscience, and/or Novoseek and Drugs according to Enzo Life Sciences and/or PharmGKB)
About This Section

Browse drugs & compounds from Enzo Life Sciences

Browse Small Molecules at Sigma-Aldrich

Browse Tocris compounds for YEATS2

(GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 219 Homo sapiens; Jun 2 2009) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView,
non coding RNAs according to RNAdb,
ESTs according to GeneTide,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from Invitrogen, Millipore, and/or Abnova,
siRNAs from Applied Biosystems, Sigma-Aldrich,
shRNA from Sigma-Aldrich, OriGene,
Tagged/untagged cDNA clones from OriGene,
Expression Assays from Applied Biosystems)
About This Section

Inhib. RNA:		Invitrogen RNAi Products for gene knock-down (YEATS2)
		Browse for Gene Knock-down Tools from Millipore
		Browse Abnova for Chimera RNAi Products

OriGene 29mer shRNA kit in GFP-retroviral vector: NM_018023

Sigma-Aldrich siRNA for YEATS2

Sigma-Aldrich shRNA for YEATS2

Explore Sigma-Aldrich super-pooled esiRNAs

Applied Biosystems Silencer® siRNAs:

NM_018023

REFSEQ mRNAs for YEATS2 gene:

NM_018023.3

Applied Biosystems TaqMan ® Gene Expression Assays:

NM_018023

              OriGene GFP tagged cDNA clone in CMV expression vector: NM_018023
                                 Myc/DDK tagged cDNA clone in CMV expression vector: NM_018023
                                 untagged cDNA clones in CMV expression vector (see all 2): AK022903

Additional cDNA sequence:

AB033023.1 AK022903.1 AK023370.1 AK090720.1 AK091654.1 BC009276.2 BC032368.1 BC043393.1

BC082270.1 BC150273.1 CR605431.1

13 DOTS entries:

DT.111774 DT.95185210 DT.92445435 DT.99995340 DT.100789471 DT.100732010 DT.95327588 DT.120895146

DT.92445439 DT.99926964 DT.100789469 DT.102821182 DT.97846459

24/228 AceView cDNA sequences (see all 228 ):

BQ056665 AA630045 BM551543 BC043393 BM551754 CR605431 CD300788 BU543752

AW875926 CB216757 BQ183768 BQ058052 CB306435 BM723029 BU855223 BU739177

NM_018023 AB033023 BQ432061 BM763112 AJ710085 AI968000 BG059827 AK091654

highest scoring ESTs for YEATS2:

AA313774 AB033023 AK022903 AL597488 AU117885 AU125187 AW277036 BC009276 BE003882 BE019159

Unigene Cluster for YEATS2:

YEATS domain containing 2

Hs.632575 [show with all ESTs]

Unigene Representative Sequence: BC150273

GeneLoc Exon Structure

2 Ensembl transcripts including schematic representations:

ENST00000305135 ENST00000273660

(Experimental results according to ¹GeneNote and GNF BioGPS,
probe sets-to-genes annotations according to ²GeneAnnot , ³GeneTide , Sets of similar genes according to GeneDecks, Electronic Northern calculations according to data from UniGene (Build 219 Homo sapiens), SAGE tags according to CGAP, plus additional links to SOURCE, and/or GNF BioGPS, and/or EXPOLDB, and/or UniProtKB,
Expression Assays from Applied Biosystems )
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YEATS2 expression in normal and diseased human tissues

Applied Biosystems TaqMan ® Gene Expression Assays for YEATS2

¹ / ² / ³

4 probe-sets matching YEATS2 gene

Affymetrix probe-set	Array	# genes	Sensitivity	Specificity	Correlation	Length	Gb_Accession	Consensus	Uniqueness	Score	Rank
Affymetrix probe-set	Array	GeneAnnot data			GeneNote data		GeneTide data
54098_at²^{, 3}	U95-B	1	1.00	1.00	1.00	1.00	AI816255	0.60	1.00	0.82	1
221203_s_at²^{, 3}	U133-A	1	1.00	1.00	--	--	NM_018023	0.60	1.00	0.82	1
221203_s_at²	U133Plus2	1	1.00	1.00	--	--	--	--	--	--	--
1557047_at²	U133Plus2	1	1.00	1.00	--	--	--	--	--	--	--

GeneDecks YEATS2 for binary patterns associated with the probe-sets selected above

About GeneDecksing

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Data from

(Publications) and GNF BioGPS
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About these images

CGAP SAGE TAG: GCTACACCCC

SOURCE GeneReport for Unigene cluster: Hs.632575

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD and/or ⁵MGI Jun 06 2009, with possible further links to Flybase and/or WormBase, Gene Trees according to Ensembl)
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Orthologs for YEATS2 gene from 5/9 species (see all 9 )

Organism	Gene	Locus	Description	Human Similarity	NCBI accessions
dog (Canis familiaris)	YEATS2¹	--	YEATS domain containing 2	91.22(n) 94.39(a)	488099 XM_545223.2 XP_545223.2
chimpanzee (Pan troglodytes)	YEATS2¹	--	YEATS domain containing 2	99.29(n) 99.44(a)	460875 XM_001135033.1 XP_001135033.1
cow (Bos taurus)	YEATS2¹	--	YEATS domain containing 2	91.22(n) 94.11(a)	514192 XM_592001.3 XP_592001.3
rat (Rattus norvegicus)	Yeats2¹	--	YEATS domain containing 2	83.88(n) 86.97(a)	498112 XM_573318.2 XP_573318.2
mouse (Mus musculus)	Yeats2^{1, 5}	16⁵	YEATS domain containing 2^{1, 5}	84.86(n)¹ 87.06(a)¹	208146¹ NM_001033237.1¹ NP_001028409.1¹ AA138143⁵ AK122463⁵ (see all 14)

About this table Species with no ortholog for YEATS2

ENSEMBL Gene Tree for YEATS2

(Paralogs according to ¹HomoloGene
and ²Ensembl, Pseudogenes according to ³Pseudogene.org)
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Paralogs for YEATS2 gene

YEATS4²

(According to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, and UniProtKB, Linkage Disequilibrium by HapMap, Genotyping Reagents from Applied Biosystems)
About This Section

10/647 NCBI SNPs in YEATS2 are shown (see all 647 )
(Click for Applied Biosystems TaqMan ® Genotyping Assay) (see all 167)

AB	SNP ID	Valid	Chr 3 pos	Sequence	Recs	AA Chg	Type	More	Recs	Pop	Total sample	More
AB	Genomic Data				Transcription Data				Allele Frequencies
				--	--	--		--	--			--
	rs263024^1,2	A,C,F,H,O	185011136(-)	`TTCCCA/GAGCAG`	1	--	ut3¹ ese³		8	EU EA WA NA	2036
	rs262993^1,2	A,C,F,H	184959379(-)	`GGAGAC/TCTGAG`	1	V/I	mis¹ ese³		9	MN EU EA WA	1016
	rs3211095^1,2	C,F,H	184991344(+)	`CAGCAG/TCAAGT`	1	Q/H	mis¹ ese³		13	MN EU EA WA	1416
	rs16858033^1,2	C,F,H	184924913(+)	`CTAGAA/GTTACT`	1	I/V	mis¹ ese³		12	NA EU EA WA	1050
--	rs9836489^1,2	A,C,F	185013212(+)	`CCTCTA/GCTTCT`	1	--	ng3¹		3	NA	142
--	rs10937149^1,2	A,F,H	184897266(+)	`ATTAgG/Cctggg`	1	--	ng5¹		3	EA WA	298
--	rs9874346^1,2	C,F,H	185013025(+)	`TCCACA/C/GTGTGT`	1	--	ut3¹ ese³		7	EU EA WA NA	562
	rs9816973^1,2	H	184896810(+)	`GACCTC/GTGACC`	1	--	ng5¹ tfbs³		4	EU EA WA	396
	rs3736535^1,2	A,C,F,H	184915677(-)	`GGGTCG/AGTTTC`	1	T/T	syn¹ ese³		12	EA NA EU WA	2352
	rs34099456^1,2	F	184952617(-)	`GACTCC/TGAGGA`	1	S/S	syn¹		1	NA	70

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HapMap Linkage Disequilibrium images for YEATS2 (up to first 250kb)

(in which this Gene is Involved, According to OMIM, UniProtKB, PharmGKB, Genatlas, GeneTests, Blood group antigen gene mutations by BGMUT, HGMD, GAD, HuGE Navigator, BCGD, and/or TGDB.)
About This Section

(Possibly Related Articles in Doctor's Guide)
About This Section

(in PubMed. Associations of this gene to articles via ¹Novoseek, ²HGNC, ³Entrez Gene, ⁴UniProtKB/Swiss-Prot, ⁵UniProtKB/TrEMBL, ⁶GAD, and/or ⁷PharmGKB)
About This Section

9 PubMed articles for YEATS2 gene:

Prediction of the coding sequences of unidentified human genes. XV. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro. (PubMed id 10574462)^{2, 3, 4} Nagase T....Ohara O. (1999)
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)^{3, 4} Gerhard D.S....Malek J. (2004)
Large-scale characterization of HeLa cell nuclear phosphoproteins. (PubMed id 15302935)^{3, 4} Beausoleil S.A....Gygi S.P. (2004)
Kinase-selective enrichment enables quantitative phosphoproteomics of the kinome across the cell cycle. (PubMed id 18691976)⁴ Daub H.... Mann M. (2008)
A quantitative atlas of mitotic phosphorylation. (PubMed id 18669648)⁴ Dephoure N.... Gygi S.P. (2008)
ATM and ATR substrate analysis reveals extensive protein networks responsive to DNA damage. (PubMed id 17525332)⁴ Matsuoka S.... Elledge S.J. (2007)
The DNA sequence, annotation and analysis of human chromosome 3. (PubMed id 16641997)⁴ Muzny D.M....Gibbs R.A. (2006)
Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)³ Ota T....Sugano S. (2004)
Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)³ Strausberg R.L....Marra M.A. (2002)

(in PubMed, OMIM, and NCBI Bookshelf)
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		AND	OR
Aliases
Free Text

Query String		PubMed OMIM NCBI Bookshelf
	(Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, and/or H-InvDB)
About This Section

Entrez Gene: 55689	HGNC: 25489	AceView: YEATS2	Ensembl:ENSG00000163872	euGenes: HUgn55689
ECgene: YEATS2	H-InvDB: YEATS2

(According to HUGE)
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HUGE: KIAA1197

(According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section

Licensable Technologies for YEATS2
(Available from WIS Yeda, Salk, Tufts)

About This Section

(Reagents available from Applied Biosystems, Antibodies and assays by Cell Signaling Technology, Abcam, Novus Biologicals,
Sigma-Aldrich, R&D Systems, Millipore, Abnova, and/or Invitrogen, Clones available from OriGene,and/or Invitrogen, Drugs and/or compounds by Sigma-Aldrich,
Enzo Life Sciences, and/or Tocris Bioscience)
About This Section

Products for YEATS2:

TaqMan ® Gene Expression Assays

TaqMan ® Genotyping Assays

Free SNP selection tool

Invitrogen iPath Pathways	Invitrogen BLOCK-iT™ RNAi
Invitrogen Antibodies	Invitrogen Assays
Invitrogen Clones	Invitrogen Q-PCR Products
Invitrogen Human Recombinant Kinases	Invitrogen Custom Antibody and Peptide Service
Invitrogen Proteins / Assays / Screening Services	Search Invitrogen catalog for YEATS2-related products

	Millipore Custom Antibody & Bulk Services
	Millipore Preclinical / Clinical Development Services
	Millipore Immunoassay Services
	Millipore Target Screening & Profiling Services

	Predesigned and custom siRNAs for YEATS2		Browse antibodies at Sigma-Aldrich
	Explore super-pooled esiRNAs		Browse proteins at Sigma-Aldrich
	Lentivirus-delivered shRNAs for YEATS2		Browse small molecules at Sigma-Aldrich
	"Your Favorite Gene" Pathways		feedback

	Antibodies		Primer Pairs
	Cell Culture Products		ELISAs
	Flow Cytometry Kits		Protease Activity Assays & Reagents
	Cell Selection/Detection Kits & Reagents		ELISA/Assay Development Kits & Reagents
	Multiplex/Array Assay Kits & Reagents		ELISpot Kits & Development Modules
	Recombinant & Natural Proteins

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	Search for Chimera RNAi
	Custom Service for Mouse Mab
	Custom Service for Rabbit Pab from Full-length Protein

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Search OriGene for YEATS2

Search Tocris compounds for YEATS2

Search www.enzolifesicences.com for proteins, assays, substrates, inhibitors & antibodies

Search Novus for antibodies for YEATS2

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YEATS2 Gene

protein-coding GIFtS: 46

Aliases &
Descriptions
for YEATS2

Summaries
for YEATS2

Genomic Location
for YEATS2

Proteins
for YEATS2

Protein Domains/
Families
for YEATS2

Gene Function
for YEATS2

Pathways & Interactions
for YEATS2

Drugs & Compounds
for YEATS2

Transcripts
for YEATS2

Expression
for YEATS2

Orthologs
for YEATS2

Paralogs
for YEATS2

SNPs/Variants
for YEATS2

Disorders & Mutations
for YEATS2

Medical News
for YEATS2

Publications
for YEATS2

Search for YEATS2

Genome Databases showing YEATS2

Other Databases showing YEATS2

Specialized Databases showing YEATS2

Licensable Technologies
for YEATS2

Services
for YEATS2

Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

YEATS2 Gene

protein-coding GIFtS: 46

Aliases & Descriptionsfor YEATS2

Summariesfor YEATS2

Genomic Locationfor YEATS2

Proteinsfor YEATS2

Protein Domains/Familiesfor YEATS2

Gene Functionfor YEATS2

Pathways & Interactionsfor YEATS2

Drugs & Compoundsfor YEATS2

Transcriptsfor YEATS2

Expression for YEATS2

Orthologsfor YEATS2

Paralogsfor YEATS2

SNPs/Variantsfor YEATS2

Disorders & Mutationsfor YEATS2

Medical Newsfor YEATS2

Publicationsfor YEATS2

Search for YEATS2

Genome Databases showing YEATS2

Other Databases showing YEATS2

Specialized Databases showing YEATS2

Licensable Technologiesfor YEATS2

Servicesfor YEATS2

Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

Aliases &
Descriptions
for YEATS2

Summaries
for YEATS2

Genomic Location
for YEATS2

Proteins
for YEATS2

Protein Domains/
Families
for YEATS2

Gene Function
for YEATS2

Pathways & Interactions
for YEATS2

Drugs & Compounds
for YEATS2

Transcripts
for YEATS2

Expression
for YEATS2

Orthologs
for YEATS2

Paralogs
for YEATS2

SNPs/Variants
for YEATS2

Disorders & Mutations
for YEATS2

Medical News
for YEATS2

Publications
for YEATS2

Licensable Technologies
for YEATS2

Services
for YEATS2