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Aliases for YEATS2 Gene

Aliases for YEATS2 Gene

  • YEATS Domain Containing 2 2 3
  • KIAA1197 4 6

External Ids for YEATS2 Gene

Previous GeneCards Identifiers for YEATS2 Gene

  • GC03P184899
  • GC03P183416
  • GC03P180824

Summaries for YEATS2 Gene

Entrez Gene Summary for YEATS2 Gene

  • YEATS2 is a scaffolding subunit of the ADA2A (TADA2A; MIM 602276)-containing (ATAC) histone acetyltransferase complex (Wang et al., 2008 [PubMed 18838386]).[supplied by OMIM, Apr 2010]

GeneCards Summary for YEATS2 Gene

YEATS2 (YEATS Domain Containing 2) is a Protein Coding gene. Among its related pathways are RNA Polymerase I Promoter Opening and RNA Polymerase I Promoter Opening. GO annotations related to this gene include TBP-class protein binding. An important paralog of this gene is YEATS4.

UniProtKB/Swiss-Prot for YEATS2 Gene

  • Component of the ATAC complex, a complex with histone acetyltransferase activity on histones H3 and H4.

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for YEATS2 Gene

Genomics for YEATS2 Gene

Regulatory Elements for YEATS2 Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for YEATS2 Gene

183,697,799 bp from pter
183,812,625 bp from pter
114,827 bases
Plus strand

Genomic View for YEATS2 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for YEATS2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for YEATS2 Gene

Proteins for YEATS2 Gene

  • Protein details for YEATS2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    YEATS domain-containing protein 2
    Protein Accession:
    Secondary Accessions:
    • A7E2B9
    • D3DNS9
    • Q641P6
    • Q9NW96

    Protein attributes for YEATS2 Gene

    1422 amino acids
    Molecular mass:
    150782 Da
    Quaternary structure:
    • Component of the ADA2A-containing complex (ATAC), composed of CSRP2BP, KAT2A, TADA2L, TADA3L, ZZ3, MBIP, WDR5, YEATS2, CCDC101 and DR1.
    • Sequence=BAA86511.1; Type=Erroneous initiation; Evidence={ECO:0000305};

neXtProt entry for YEATS2 Gene

Proteomics data for YEATS2 Gene at MOPED

Post-translational modifications for YEATS2 Gene

  • Ubiquitination at Lys719
  • Modification sites at PhosphoSitePlus

Other Protein References for YEATS2 Gene

ENSEMBL proteins:
Reactome Protein details:
REFSEQ proteins:

No data available for DME Specific Peptides for YEATS2 Gene

Domains for YEATS2 Gene

Gene Families for YEATS2 Gene

Protein Domains for YEATS2 Gene


Suggested Antigen Peptide Sequences for YEATS2 Gene

Graphical View of Domain Structure for InterPro Entry



  • Contains 1 YEATS domain.
  • Contains 1 YEATS domain.
genes like me logo Genes that share domains with YEATS2: view

Function for YEATS2 Gene

Molecular function for YEATS2 Gene

UniProtKB/Swiss-Prot Function:
Component of the ATAC complex, a complex with histone acetyltransferase activity on histones H3 and H4.

Gene Ontology (GO) - Molecular Function for YEATS2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 18838386
GO:0017025 TBP-class protein binding IPI 18838386
genes like me logo Genes that share ontologies with YEATS2: view

Animal Model Products

miRNA for YEATS2 Gene

miRTarBase miRNAs that target YEATS2

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for YEATS2

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Phenotypes , Animal Models , Transcription Factor Targets and HOMER Transcription for YEATS2 Gene

Localization for YEATS2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for YEATS2 Gene

Subcellular locations from

Jensen Localization Image for YEATS2 Gene COMPARTMENTS Subcellular localization image for YEATS2 gene
Compartment Confidence
nucleus 4
cytoskeleton 2
cytosol 2

Gene Ontology (GO) - Cellular Components for YEATS2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus --
GO:0005671 Ada2/Gcn5/Ada3 transcription activator complex IDA 18838386
GO:0072686 mitotic spindle IEA --
genes like me logo Genes that share ontologies with YEATS2: view

Pathways for YEATS2 Gene

genes like me logo Genes that share pathways with YEATS2: view

Pathways by source for YEATS2 Gene

Gene Ontology (GO) - Biological Process for YEATS2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000122 negative regulation of transcription from RNA polymerase II promoter IDA 18838386
GO:0006325 chromatin organization TAS --
GO:0006355 regulation of transcription, DNA-templated --
GO:0043966 histone H3 acetylation IDA 18838386
GO:0045892 negative regulation of transcription, DNA-templated IDA 18838386
genes like me logo Genes that share ontologies with YEATS2: view

Transcripts for YEATS2 Gene

Unigene Clusters for YEATS2 Gene

YEATS domain containing 2:
Representative Sequences:

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for YEATS2

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for YEATS2 Gene

No ASD Table

Relevant External Links for YEATS2 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for YEATS2 Gene

mRNA expression in normal human tissues for YEATS2 Gene

Protein differential expression in normal tissues for YEATS2 Gene

This gene is overexpressed in Breast (56.5) and Heart (6.4).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for YEATS2 Gene

SOURCE GeneReport for Unigene cluster for YEATS2 Gene Hs.632575

genes like me logo Genes that share expressions with YEATS2: view

Primer Products

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Expression partners for YEATS2 Gene

Orthologs for YEATS2 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for YEATS2 Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia YEATS2 35
  • 91.01 (n)
  • 93.75 (a)
  • 93 (a)
(Canis familiaris)
Mammalia YEATS2 35
  • 91.08 (n)
  • 93.97 (a)
  • 94 (a)
(Mus musculus)
Mammalia Yeats2 35
  • 84.86 (n)
  • 87.26 (a)
Yeats2 16
Yeats2 36
  • 87 (a)
(Pan troglodytes)
Mammalia YEATS2 35
  • 98.56 (n)
  • 98.66 (a)
  • 99 (a)
(Rattus norvegicus)
Mammalia Yeats2 35
  • 83.62 (n)
  • 86.75 (a)
(Monodelphis domestica)
Mammalia YEATS2 36
  • 82 (a)
(Ornithorhynchus anatinus)
Mammalia -- 36
  • 79 (a)
-- 36
  • 88 (a)
-- 36
  • 82 (a)
(Gallus gallus)
Aves YEATS2 35
  • 73.62 (n)
  • 76.75 (a)
  • 76 (a)
(Anolis carolinensis)
Reptilia YEATS2 36
  • 72 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia Str.10908 35
yeats2 35
  • 65.44 (n)
  • 62.99 (a)
African clawed frog
(Xenopus laevis)
Amphibia MGC68945 35
(Danio rerio)
Actinopterygii yeats2 35
  • 61.17 (n)
  • 60.02 (a)
yeats2 36
  • 53 (a)
fruit fly
(Drosophila melanogaster)
Insecta D12 36
  • 11 (a)
(Caenorhabditis elegans)
Secernentea Y105E8B.7 36
  • 16 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes YAF9 36
  • 25 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 73 (a)
Species with no ortholog for YEATS2:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for YEATS2 Gene

Gene Tree for YEATS2 (if available)
Gene Tree for YEATS2 (if available)

Paralogs for YEATS2 Gene

Paralogs for YEATS2 Gene

(1) SIMAP similar genes for YEATS2 Gene using alignment to 3 proteins:

genes like me logo Genes that share paralogs with YEATS2: view

Variants for YEATS2 Gene

Sequence variations from dbSNP and Humsavar for YEATS2 Gene

SNP ID Clin Chr 03 pos Sequence Context AA Info Type MAF
rs166397 -- 183,751,003(-) ggaca(C/T)gacac intron-variant
rs166398 -- 183,729,189(-) GTTCA(C/T)GCCAT intron-variant
rs185506 -- 183,771,288(-) CCACA(A/G)GGTTG intron-variant
rs187808 -- 183,771,186(-) accaa(A/G)aagtt intron-variant
rs189714 -- 183,795,202(-) GGTTT(A/T)ttctt intron-variant

Structural Variations from Database of Genomic Variants (DGV) for YEATS2 Gene

Variant ID Type Subtype PubMed ID
nsv507144 CNV Insertion 20534489
esv2726292 CNV Deletion 23290073

Relevant External Links for YEATS2 Gene

HapMap Linkage Disequilibrium report

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for YEATS2 Gene

Disorders for YEATS2 Gene

Relevant External Links for YEATS2

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator

No disorders were found for YEATS2 Gene.

No data available for MalaCards , OMIM , UniProtKB/Swiss-Prot , University of Copenhagen DISEASES , Novoseek inferred disease relationships and Genatlas for YEATS2 Gene

Publications for YEATS2 Gene

  1. Prediction of the coding sequences of unidentified human genes. XV. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro. (PMID: 10574462) Nagase T. … Ohara O. (DNA Res. 1999) 2 3 4
  2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4
  3. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose J.E. … Uhl G.R. (Mol. Med. 2010) 3 48
  4. Quantitative interaction proteomics and genome-wide profiling of epigenetic histone marks and their readers. (PMID: 20850016) Vermeulen M. … Mann M. (Cell 2010) 3
  5. Mass spectrometric analysis of lysine ubiquitylation reveals promiscuity at site level. (PMID: 21139048) Danielsen J.M. … Nielsen M.L. (Mol. Cell Proteomics 2011) 3

Products for YEATS2 Gene

Sources for YEATS2 Gene

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