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Aliases for YEATS2 Gene

Aliases for YEATS2 Gene

  • YEATS Domain Containing 2 2 3
  • KIAA1197 4

External Ids for YEATS2 Gene

Previous GeneCards Identifiers for YEATS2 Gene

  • GC03P184899
  • GC03P183416
  • GC03P180824

Summaries for YEATS2 Gene

Entrez Gene Summary for YEATS2 Gene

  • YEATS2 is a scaffolding subunit of the ADA2A (TADA2A; MIM 602276)-containing (ATAC) histone acetyltransferase complex (Wang et al., 2008 [PubMed 18838386]).[supplied by OMIM, Apr 2010]

GeneCards Summary for YEATS2 Gene

YEATS2 (YEATS Domain Containing 2) is a Protein Coding gene. Among its related pathways are Chromatin organization. GO annotations related to this gene include TBP-class protein binding. An important paralog of this gene is YEATS4.

UniProtKB/Swiss-Prot for YEATS2 Gene

  • Component of the ATAC complex, a complex with histone acetyltransferase activity on histones H3 and H4.

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for YEATS2 Gene

Genomics for YEATS2 Gene

Regulatory Elements for YEATS2 Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for YEATS2 Gene

Chromosome:
3
Start:
183,697,804 bp from pter
End:
183,812,625 bp from pter
Size:
114,822 bases
Orientation:
Plus strand

Genomic View for YEATS2 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for YEATS2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for YEATS2 Gene

Proteins for YEATS2 Gene

  • Protein details for YEATS2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9ULM3-YETS2_HUMAN
    Recommended name:
    YEATS domain-containing protein 2
    Protein Accession:
    Q9ULM3
    Secondary Accessions:
    • A7E2B9
    • D3DNS9
    • Q641P6
    • Q9NW96

    Protein attributes for YEATS2 Gene

    Size:
    1422 amino acids
    Molecular mass:
    150782 Da
    Quaternary structure:
    • Component of the ADA2A-containing complex (ATAC), composed of CSRP2BP, KAT2A, TADA2L, TADA3L, ZZ3, MBIP, WDR5, YEATS2, CCDC101 and DR1.
    SequenceCaution:
    • Sequence=BAA86511.1; Type=Erroneous initiation; Evidence={ECO:0000305};

neXtProt entry for YEATS2 Gene

Proteomics data for YEATS2 Gene at MOPED

Post-translational modifications for YEATS2 Gene

  • Ubiquitination at Lys 719
  • Modification sites at PhosphoSitePlus

Other Protein References for YEATS2 Gene

ENSEMBL proteins:
REFSEQ proteins:

Antibody Products

No data available for DME Specific Peptides for YEATS2 Gene

Domains & Families for YEATS2 Gene

Gene Families for YEATS2 Gene

Protein Domains for YEATS2 Gene

InterPro:
Blocks:
ProtoNet:

Suggested Antigen Peptide Sequences for YEATS2 Gene

Graphical View of Domain Structure for InterPro Entry

Q9ULM3

UniProtKB/Swiss-Prot:

YETS2_HUMAN :
  • Contains 1 YEATS domain.
Domain:
  • Contains 1 YEATS domain.
genes like me logo Genes that share domains with YEATS2: view

Function for YEATS2 Gene

Molecular function for YEATS2 Gene

UniProtKB/Swiss-Prot Function:
Component of the ATAC complex, a complex with histone acetyltransferase activity on histones H3 and H4.

Gene Ontology (GO) - Molecular Function for YEATS2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 18838386
GO:0017025 TBP-class protein binding IPI 18838386
genes like me logo Genes that share ontologies with YEATS2: view
genes like me logo Genes that share phenotypes with YEATS2: view

Animal Model Products

miRNA for YEATS2 Gene

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for YEATS2

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targets and HOMER Transcription for YEATS2 Gene

Localization for YEATS2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for YEATS2 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for YEATS2 Gene COMPARTMENTS Subcellular localization image for YEATS2 gene
Compartment Confidence
nucleus 4
cytoskeleton 2

Gene Ontology (GO) - Cellular Components for YEATS2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus --
GO:0005671 Ada2/Gcn5/Ada3 transcription activator complex IDA 18838386
GO:0072686 mitotic spindle IEA --
genes like me logo Genes that share ontologies with YEATS2: view

Pathways & Interactions for YEATS2 Gene

genes like me logo Genes that share pathways with YEATS2: view

Pathways by source for YEATS2 Gene

Gene Ontology (GO) - Biological Process for YEATS2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000122 negative regulation of transcription from RNA polymerase II promoter IDA 18838386
GO:0006325 chromatin organization TAS --
GO:0006355 regulation of transcription, DNA-templated --
GO:0043966 histone H3 acetylation IDA 18838386
GO:0045892 negative regulation of transcription, DNA-templated IDA 18838386
genes like me logo Genes that share ontologies with YEATS2: view

No data available for SIGNOR curated interactions for YEATS2 Gene

Drugs & Compounds for YEATS2 Gene

No Compound Related Data Available

Transcripts for YEATS2 Gene

Unigene Clusters for YEATS2 Gene

YEATS domain containing 2:
Representative Sequences:

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for YEATS2

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for YEATS2 Gene

No ASD Table

Relevant External Links for YEATS2 Gene

GeneLoc Exon Structure for
YEATS2
ECgene alternative splicing isoforms for
YEATS2

Expression for YEATS2 Gene

mRNA expression in normal human tissues for YEATS2 Gene

Protein differential expression in normal tissues from HIPED for YEATS2 Gene

This gene is overexpressed in Breast (56.5) and Heart (6.4).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for YEATS2 Gene



SOURCE GeneReport for Unigene cluster for YEATS2 Gene Hs.632575

genes like me logo Genes that share expression patterns with YEATS2: view

Primer Products

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Protein tissue co-expression partners for YEATS2 Gene

Orthologs for YEATS2 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for YEATS2 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia YEATS2 35
  • 91.01 (n)
  • 93.75 (a)
YEATS2 36
  • 93 (a)
OneToOne
dog
(Canis familiaris)
Mammalia YEATS2 35
  • 91.08 (n)
  • 93.97 (a)
YEATS2 36
  • 94 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Yeats2 35
  • 84.86 (n)
  • 87.26 (a)
Yeats2 16
Yeats2 36
  • 87 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia YEATS2 35
  • 98.56 (n)
  • 98.66 (a)
YEATS2 36
  • 99 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Yeats2 35
  • 83.62 (n)
  • 86.75 (a)
oppossum
(Monodelphis domestica)
Mammalia YEATS2 36
  • 82 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia -- 36
  • 79 (a)
OneToMany
-- 36
  • 88 (a)
OneToMany
-- 36
  • 82 (a)
OneToMany
chicken
(Gallus gallus)
Aves YEATS2 35
  • 73.62 (n)
  • 76.75 (a)
YEATS2 36
  • 76 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia YEATS2 36
  • 72 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia Str.10908 35
yeats2 35
  • 65.44 (n)
  • 62.99 (a)
African clawed frog
(Xenopus laevis)
Amphibia MGC68945 35
zebrafish
(Danio rerio)
Actinopterygii yeats2 35
  • 61.17 (n)
  • 60.02 (a)
yeats2 36
  • 53 (a)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta D12 36
  • 11 (a)
OneToOne
worm
(Caenorhabditis elegans)
Secernentea Y105E8B.7 36
  • 16 (a)
ManyToMany
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes YAF9 36
  • 25 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 73 (a)
OneToOne
Species with no ortholog for YEATS2:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for YEATS2 Gene

ENSEMBL:
Gene Tree for YEATS2 (if available)
TreeFam:
Gene Tree for YEATS2 (if available)

Paralogs for YEATS2 Gene

Paralogs for YEATS2 Gene

(1) SIMAP similar genes for YEATS2 Gene using alignment to 3 proteins:

genes like me logo Genes that share paralogs with YEATS2: view

Variants for YEATS2 Gene

Sequence variations from dbSNP and Humsavar for YEATS2 Gene

SNP ID Clin Chr 03 pos Sequence Context AA Info Type MAF
rs166397 -- 183,751,003(-) ggaca(C/T)gacac intron-variant
rs166398 -- 183,729,189(-) GTTCA(C/T)GCCAT intron-variant
rs185506 -- 183,771,288(-) CCACA(A/G)GGTTG intron-variant
rs187808 -- 183,771,186(-) accaa(A/G)aagtt intron-variant
rs189714 -- 183,795,202(-) GGTTT(A/T)ttctt intron-variant

Structural Variations from Database of Genomic Variants (DGV) for YEATS2 Gene

Variant ID Type Subtype PubMed ID
nsv507144 CNV Insertion 20534489
esv2726292 CNV Deletion 23290073

Variation tolerance for YEATS2 Gene

Residual Variation Intolerance Score: 33.35% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 13.87; 95.89% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for YEATS2 Gene

HapMap Linkage Disequilibrium report
YEATS2

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for YEATS2 Gene

Disorders for YEATS2 Gene

Relevant External Links for YEATS2

Genetic Association Database (GAD)
YEATS2
Human Genome Epidemiology (HuGE) Navigator
YEATS2
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
YEATS2
genes like me logo Genes that share disorders with YEATS2: view

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for YEATS2 Gene

Publications for YEATS2 Gene

  1. Prediction of the coding sequences of unidentified human genes. XV. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro. (PMID: 10574462) Nagase T. … Ohara O. (DNA Res. 1999) 2 67
  2. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 67
  3. An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome. (PMID: 24275569) Bian Y. … Zou H. (J. Proteomics 2014) 67
  4. A census of human soluble protein complexes. (PMID: 22939629) Havugimana P.C. … Emili A. (Cell 2012) 67
  5. Insights into RNA biology from an atlas of mammalian mRNA-binding proteins. (PMID: 22658674) Castello A. … Hentze M.W. (Cell 2012) 67

Products for YEATS2 Gene

Sources for YEATS2 Gene

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