YEATS2 Gene
protein-coding GIFtS: 46
GCID: GC03P183416
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YEATS domain containing 2
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Aliases
for YEATS2 gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| YEATS Domain Containing 21 2 | | KIAA11971 3 5 | | FLJ102011 | | FLJ128411 | | FLJ133081 | | YEATS Domain-Containing Protein 22 |
Export aliases for YEATS2 gene to outside databasesPrevious GC identifers: GC03P184899 GC03P180824 |
Summaries
for YEATS2 gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
Entrez Gene summary for YEATS2:
YEATS2 is a scaffolding subunit of the ADA2A (TADA2A; MIM 602276)-containing (ATAC) histone acetyltransferase complex(Wang et al., 2008 (PubMed 18838386)).(supplied by OMIM, Apr 2010)
UniProtKB/Swiss-Prot: YETS2_HUMAN, Q9ULM3Function: Component of the ATAC complex, a complex with histone acetyltransferase activity on histones H3 and H4
|
Genomic Views
for YEATS2 gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000003.11 NC_018914.1 NT_005612.16
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the YEATS2 gene promoter:
CRE-BP1 AML1a POU2F1 ATF-2 POU2F1a FOXO1a FOXO1 En-1
Other transcription factors
Search SABiosciences Chromatin IP Primers for YEATS2
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat YEATS2 |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 3q27.1 Ensembl cytogenetic band: 3q27.1 HGNC cytogenetic band: 3q27.3YEATS2 Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 3 GeneLoc Exon Structure GeneLoc location for GC03P183416: view genomic region
(about GC identifiers)
Start:
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183,415,606 bp from pter |
End:
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183,530,413 bp from pter |
Size:
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114,808 bases |
Orientation:
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plus strand |
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Proteins
for YEATS2 gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: YETS2_HUMAN, Q9ULM3 (See
protein sequence)Recommended Name: YEATS domain-containing protein 2 Size: 1422 amino acids; 150782 Da
Subunit: Component of the ADA2A-containing complex (ATAC), composed of CSRP2BP, KAT2A, TADA2L, TADA3L, ZZ3, MBIP, WDR5,YEATS2, CCDC101 and DR1
Subcellular location: Nucleus (Probable)
Sequence caution: Sequence=BAA86511.1; Type=Erroneous initiation;
Secondary accessions: A7E2B9 D3DNS9 Q641P6 Q9NW96Explore the universe of human proteins at neXtProt for YEATS2: NX_Q9ULM3
Post-translational modifications:
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_Q9ULM3
YEATS2 Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins: NP_060493.3
ENSEMBL proteins: ENSP00000408249 ENSP00000406477 ENSP00000306983
Human Recombinant Protein Products for YEATS2:
Gene Ontology (GO): 2 cellular component terms (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0005671 | Ada2/Gcn5/Ada3 transcription activator complex |
IDA | 18838386 | | GO:0072686 | mitotic spindle |
IEA | -- |
YEATS2 for ontologies About GeneDecksing
YEATS2 Antibody Products:
Assay Products for YEATS2: |
Protein
Domains /
Families
for YEATS2 gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
YEATS2 for domains About GeneDecksing
1 InterPro domain/family:Graphical View of Domain Structure for InterPro Entry Q9ULM3ProtoNet protein and cluster: Q9ULM3 1 Blocks protein family: IPB005033 YEATS family
UniProtKB/Swiss-Prot: YETS2_HUMAN, Q9ULM3Similarity: Contains 1 YEATS domain |
Function
for YEATS2 gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
inGenious Targeting Laboratory,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase,
shRNA from
OriGene,
Sirion Biotech,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Sirion Biotech,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
Sirion Biotech,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Molecular Function:
UniProtKB/Swiss-Prot Summary: YETS2_HUMAN, Q9ULM3Function: Component of the ATAC complex, a complex with histone acetyltransferase activity on histones H3 and H4 Gene Ontology (GO): 2 molecular function terms (GO ID links to tree view): About this table
YEATS2 for ontologies About GeneDecksing
Animal Models:
Clone
Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for YEATS2 (see all 5)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for YEATS2
OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling 
| |  | GenScript: all cDNA clones in your preferred vector: YEATS2 (NM_018023) | |  | Browse Sino Biological Human cDNA Clones | |  | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for YEATS2 | |  | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat YEATS2 |
In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for YEATS2 |
|
Pathways & Interactions
for YEATS2 gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Interactions:
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for YEATS2
STRING Interaction
Network Preview (showing 5 interactants - click image to see 17)
5/21 Interacting proteins for YEATS2 (Q9ULM33 ENSP000003069834) via UniProtKB, MINT, STRING, and/or I2D (see all 21)About this table
Gene Ontology (GO): 3 biological process terms (GO ID links to tree view): About this table
YEATS2 for ontologies About GeneDecksing
|
Drugs & Compounds
for YEATS2 gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
 Browse Tocris compounds for YEATS2
Search CenterWatch for drugs/clinical trials and news about YEATS2 / YETS2
|
Transcripts
for YEATS2 gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
Sirion Biotech,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for YEATS2 gene: NM_018023.4 Unigene Cluster for YEATS2: YEATS domain containing 2 Hs.632575 [show with all ESTs]Unigene Representative Sequence: BC1502737 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000421660 ENST00000432781(uc003flz.3) ENST00000497765 ENST00000472593
ENST00000481343 ENST00000468850 ENST00000305135(uc003fly.2)
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for YEATS2 (see all 5)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for YEATS2
OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector: YEATS2 (NM_018023) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for YEATS2 | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat YEATS2 |
Additional cDNA sequence: AB033023.1 AK022903.1 AK023370.1 AK090720.1 AK091654.1 BC009276.2 BC032368.1 BC043393.1 BC082270.1 BC150273.1 13 DOTS entries: DT.111774 DT.95185210 DT.92445435 DT.99995340 DT.100789471 DT.100732010 DT.120895146 DT.92445439 DT.95327588 DT.100789469 DT.102821182 DT.99926964 DT.97846459 24/228 AceView cDNA sequences (see all 228): BG059827 BQ071035 AI816336 BQ183768 AI968000 AA630045 AI341256 BU739177 BM551754 BQ641961 AX747114 BU543752 BM551543 AA654765 BG912568 AJ710085 CA416892 AU131903 BU855223 CA426139 AB033023 BE299815 AW408671 AK091654
GeneLoc Exon Structure
|
Expression
for YEATS2 gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| YEATS2 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: GCTACACCCC
About this image
See YEATS2 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for YEATS2
SOURCE GeneReport for Unigene cluster: Hs.632575
SABiosciences Custom PCR Arrays for YEATS2
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for YEATS2
Browse OriGene validated miRNA SYBR primer pairs
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse, rat YEATS2 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat YEATS2 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat YEATS2 | In Situ
Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for YEATS2 |
Orthologs
for YEATS2 gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of eukaryotes.
Orthologs for YEATS2 gene from 8/26 species (see all 26) About this table
ENSEMBL Gene Tree for YEATS2 (if available)
TreeFam Gene Tree for YEATS2 (if available) |
Paralogs
for YEATS2 gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| Paralogs for YEATS2 gene
- YEATS42
1 SIMAP similar gene for YEATS2 using alignment to 3 protein entries: YETS2_HUMAN (see all proteins):YEATS4
YEATS2 for paralogs About GeneDecksing
|
Genomic Variants
for YEATS2 gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 3 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for YEATS2 (183415606 - 183530413 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV) variations for YEATS2: -- | SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing YEATS2 |
|
Disorders
/ Diseases
for YEATS2 gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
YEATS2 for disorders About GeneDecksing
OMIM gene information: 613373
OMIM disorders: --
1  disease for YEATS2: About MalaCardsmalaria
Human Genome Epidemiology (HuGE) Navigator: YEATS2 (1 document)
Export disorders for YEATS2 gene to outside databases
|
Publications
for YEATS2 gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for YEATS2 gene, integrated from 9 sources (see all 21):
(articles sorted by number of sources associating them with YEATS2) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- Prediction of the coding sequences of unidentified human genes. XV. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro. (PubMed id 10574462)1, 2, 3 Nagase T.... Ohara O. (1999)
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
- A census of human soluble protein complexes. (PubMed id 22939629)1 Havugimana P.C....Emili A. (2012)
- A cohesin-RAD21 interactome. (PubMed id 22145905)1 Panigrahi A.K....Pati D. (2012)
- Systematic and quantitative assessment of the ubiquiti n-modified proteome. (PubMed id 21906983)1 Kim W....Gygi S.P. (2011)
- System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation. (PubMed id 21406692)2 Rigbolt K.T....Blagoev B. (2011)
- Mass spectrometric analysis of lysine ubiquitylation r eveals promiscuity at site level. (PubMed id 21139048)1 Danielsen J.M....Nielsen M.L. (2011)
- Comparative proteomic analysis identifies a role for S UMO in protein quality control. (PubMed id 21693764)1 Tatham M.H....Hay R.T. (2011)
- Purification and identification of endogenous polySUMO conjugates. (PubMed id 21252943)1 Bruderer R....Hay R.T. (2011)
- Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PubMed id 20379614)1 Rose J.E....Uhl G.R. (2010)
|
External Searches for YEATS2 gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
|
Genome Databases showing YEATS2 gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing YEATS2 gene
(According to HUGE)
About This Section
| |
Specialized Databases showing YEATS2 gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
| Name | Description |
| PharmGKB entry for YEATS2 | Pharmacogenomics, SNPs, Pathways |
|
| | |
About This Section
| Patent Information for YEATS2 gene:
Search GeneIP for patents involving YEATS2
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for YEATS2 gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript, LifeMap BioReagents, and Sirion Biotech, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences, In Situ Hybridization Assays from
Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory)
About This Section
|
 | |
 | |
 |
| | |  | Browse OriGene Antibodies | | OriGene shRNA RFP for YEATS2 | | | OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for YEATS2 | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for YEATS2 | | | Browse OriGene Protein Over-expression Lysates | | Browse OriGene Fluorogenic Cell Assay Kits | | | Browse OriGene siRNAs | | OriGene 3'-UTR Clone for YEATS2 | | | OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for YEATS2 | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for YEATS2 | | | Browse OriGene GFP tagged cDNA clones in CMV expression vector | | Browse OriGene MicroRNA Expression Plasmids | | | Browse OriGene basic RS shRNAs | | Browse OriGene validated miRNA SYBR primer pairs | | | Browse OriGene full length recombinant human proteins expressed in human HEK293 cells | | OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling | | | OriGene Custom Antibody Services for YEATS2 | | OriGene Custom Protein Services for YEATS2 | | | OriGene Custom Immunoassay Development | | |
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| | | QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat YEATS2 | | | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing YEATS2 | | | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat YEATS2 | | | QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat YEATS2 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat YEATS2 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat YEATS2 |
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| | | | Search Tocris compounds for YEATS2 |
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 | | | YEATS2 Proteins, Antibodies, CLIAs, and ELISAs |
| | | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for YEATS2 |
|  |  |  |  | | | | Search ThermoFisher Antibodies for YEATS2 |
| | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat YEATS2 |
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