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Aliases for YDJC Gene

Aliases for YDJC Gene

  • YdjC Homolog (Bacterial) 2 3
  • EC 3.5.1.- 4

External Ids for YDJC Gene

Previous GeneCards Identifiers for YDJC Gene

  • GC22M020312
  • GC22M021982
  • GC22M004940

Summaries for YDJC Gene

GeneCards Summary for YDJC Gene

YDJC (YdjC Homolog (Bacterial)) is a Protein Coding gene. GO annotations related to this gene include magnesium ion binding and hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds.

UniProtKB/Swiss-Prot for YDJC Gene

  • Probably catalyzes the deacetylation of acetylated carbohydrates an important step in the degradation of oligosaccharides.

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for YDJC Gene

Genomics for YDJC Gene

Regulatory Elements for YDJC Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for YDJC Gene

Chromosome:
22
Start:
21,628,089 bp from pter
End:
21,630,325 bp from pter
Size:
2,237 bases
Orientation:
Minus strand

Genomic View for YDJC Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for YDJC Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for YDJC Gene

Proteins for YDJC Gene

  • Protein details for YDJC Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    A8MPS7-YDJC_HUMAN
    Recommended name:
    Carbohydrate deacetylase
    Protein Accession:
    A8MPS7
    Secondary Accessions:
    • Q2YDT4
    • Q4V9R7

    Protein attributes for YDJC Gene

    Size:
    323 amino acids
    Molecular mass:
    34466 Da
    Cofactor:
    Name=Mg(2+); Xref=ChEBI:CHEBI:18420;
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for YDJC Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for YDJC Gene

Proteomics data for YDJC Gene at MOPED

Post-translational modifications for YDJC Gene

  • Ubiquitination at Lys 92
  • Modification sites at PhosphoSitePlus

Other Protein References for YDJC Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for YDJC Gene

Domains & Families for YDJC Gene

Protein Domains for YDJC Gene

Suggested Antigen Peptide Sequences for YDJC Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

A8MPS7

UniProtKB/Swiss-Prot:

YDJC_HUMAN :
  • Belongs to the YdjC deacetylase family.
Family:
  • Belongs to the YdjC deacetylase family.
genes like me logo Genes that share domains with YDJC: view

No data available for Gene Families for YDJC Gene

Function for YDJC Gene

Molecular function for YDJC Gene

UniProtKB/Swiss-Prot Function:
Probably catalyzes the deacetylation of acetylated carbohydrates an important step in the degradation of oligosaccharides.

Enzyme Numbers (IUBMB) for YDJC Gene

Gene Ontology (GO) - Molecular Function for YDJC Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000287 magnesium ion binding ISS --
GO:0003824 catalytic activity --
GO:0016810 hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds IEA --
genes like me logo Genes that share ontologies with YDJC: view

Phenotypes for YDJC Gene

GenomeRNAi human phenotypes for YDJC:
genes like me logo Genes that share phenotypes with YDJC: view

Animal Model Products

CRISPR Products

No data available for Animal Models , Transcription Factor Targets and HOMER Transcription for YDJC Gene

Localization for YDJC Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for YDJC Gene COMPARTMENTS Subcellular localization image for YDJC gene
Compartment Confidence
nucleus 2

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Gene Ontology (GO) - Cellular Components for YDJC Gene

Pathways & Interactions for YDJC Gene

SuperPathways for YDJC Gene

No Data Available

Interacting Proteins for YDJC Gene

STRING Interaction Network Preview (showing 1 interactants - click image to see details)
http://string-db.org/version_10/api/image/networkList?limit=0&targetmode=proteins&caller_identity=gene_cards&network_flavor=evidence&identifiers=9606.ENSP00000292778%0d%0a9606.ENSP00000344818%0d%0a
Selected Interacting proteins: ENSP00000292778 for YDJC Gene via STRING

Symbol External ID(s) Details
UBC

Gene Ontology (GO) - Biological Process for YDJC Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005975 carbohydrate metabolic process IEA --
genes like me logo Genes that share ontologies with YDJC: view

No data available for Pathways by source and SIGNOR curated interactions for YDJC Gene

Drugs & Compounds for YDJC Gene

No Compound Related Data Available

Transcripts for YDJC Gene

Unigene Clusters for YDJC Gene

YdjC homolog (bacterial):
Representative Sequences:

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for YDJC

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for YDJC Gene

ExUns: 1a · 1b · 1c · 1d · 1e ^ 2a · 2b ^ 3 ^ 4a · 4b · 4c · 4d ^ 5a · 5b · 5c · 5d · 5e · 5f
SP1:
SP2: -
SP3: - - - - -
SP4: - -
SP5: - - - -
SP6:
SP7: - - - -
SP8:
SP9: -
SP10: - - - -
SP11:

Relevant External Links for YDJC Gene

GeneLoc Exon Structure for
YDJC
ECgene alternative splicing isoforms for
YDJC

Expression for YDJC Gene

mRNA expression in normal human tissues for YDJC Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for YDJC Gene

This gene is overexpressed in Retina (26.4), Blymphocyte (19.0), CD8 Tcells (7.0), Testis (6.8), and Pancreas (6.7).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for YDJC Gene



SOURCE GeneReport for Unigene cluster for YDJC Gene Hs.355952

genes like me logo Genes that share expression patterns with YDJC: view

Protein tissue co-expression partners for YDJC Gene

Primer Products

  • QuantiTect SYBR Green Assays in human,mouse,rat
  • Pre-validated RT² qPCR Primer Assay in human,mouse,rat
  • QuantiFast Probe-based Assays in human,mouse,rat

In Situ Assay Products

No data available for mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for YDJC Gene

Orthologs for YDJC Gene

This gene was present in the common ancestor of chordates.

Orthologs for YDJC Gene

Organism Taxonomy Gene Similarity Type Details
dog
(Canis familiaris)
Mammalia YDJC 35
  • 83.59 (n)
  • 82.55 (a)
YDJC 36
  • 82 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Ydjc 35
  • 84.03 (n)
  • 89.64 (a)
Ydjc 16
Ydjc 36
  • 89 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia YDJC 35
  • 99.69 (n)
  • 99.07 (a)
YDJC 36
  • 98 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Ydjc 35
  • 83.82 (n)
  • 89 (a)
cow
(Bos Taurus)
Mammalia YDJC 36
  • 83 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia YDJC 36
  • 64 (a)
OneToOne
chicken
(Gallus gallus)
Aves YDJC 35
  • 58.36 (n)
  • 55.63 (a)
YDJC 36
  • 52 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia YDJC 36
  • 50 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia ydjc 35
  • 54.05 (n)
  • 50.68 (a)
African clawed frog
(Xenopus laevis)
Amphibia Xl.33494 35
zebrafish
(Danio rerio)
Actinopterygii ydjc 35
  • 55.82 (n)
  • 50.34 (a)
ydjc 36
  • 48 (a)
OneToOne
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 37 (a)
OneToOne
Species with no ortholog for YDJC:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for YDJC Gene

ENSEMBL:
Gene Tree for YDJC (if available)
TreeFam:
Gene Tree for YDJC (if available)

Paralogs for YDJC Gene

No data available for Paralogs for YDJC Gene

Variants for YDJC Gene

Sequence variations from dbSNP and Humsavar for YDJC Gene

SNP ID Clin Chr 22 pos Sequence Context AA Info Type MAF
rs710177 -- 21,629,916(+) GTCAC(A/G)GCCCC synonymous-codon, reference, nc-transcript-variant
rs861856 -- 21,629,564(+) TGGGG(A/G)TCCTC intron-variant, nc-transcript-variant
rs861857 -- 21,628,051(+) TTTCT(C/G)TGAGG downstream-variant-500B
rs878825 -- 21,627,960(-) GCTGC(A/G)ATTTT downstream-variant-500B
rs1046843 -- 21,628,143(-) TCACC(A/C)CTGGG utr-variant-3-prime

Structural Variations from Database of Genomic Variants (DGV) for YDJC Gene

Variant ID Type Subtype PubMed ID
nsv7350 OTHER Inversion 18451855
nsv914458 CNV Loss 21882294
dgv4881n71 CNV Loss 21882294
nsv516806 CNV Loss 19592680
dgv4882n71 CNV Loss 21882294

Variation tolerance for YDJC Gene

Gene Damage Index Score: 9.42; 88.58% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for YDJC Gene

HapMap Linkage Disequilibrium report
YDJC
Human Gene Mutation Database (HGMD)
YDJC

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for YDJC Gene

Disorders for YDJC Gene

Relevant External Links for YDJC

Genetic Association Database (GAD)
YDJC
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
YDJC
genes like me logo Genes that share disorders with YDJC: view

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for YDJC Gene

Publications for YDJC Gene

  1. Crystal structure of the YdjC-family protein TTHB029 from Thermus thermophilus HB8: structural relationship with peptidoglycan N-acetylglucosamine deacetylase. (PMID: 18177738) Imagawa T. … Tsuge H. (Biochem. Biophys. Res. Commun. 2008) 2 67
  2. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 67
  3. Genetics of rheumatoid arthritis contributes to biology and drug discovery. (PMID: 24390342) Okada Y. … Plenge R.M. (Nature 2013) 67
  4. Seventy-five genetic loci influencing the human red blood cell. (PMID: 23222517) van der Harst P. … Chambers J.C. (Nature 2012) 67
  5. Insights into RNA biology from an atlas of mammalian mRNA-binding proteins. (PMID: 22658674) Castello A. … Hentze M.W. (Cell 2012) 67

Products for YDJC Gene

Sources for YDJC Gene

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