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YDJC Gene

protein-coding GIFtS: 38

GC22M020312

YdjC homolog (bacterial)
Symbol approved by the HUGO Gene Nomenclature Committee (HGNC) database

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc , and/or ⁷Ensembl, ⁸miRBase)
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Aliases
MGC133160 ^²

Descriptions
YdjC homolog ^²
YdjC homolog (bacterial) ^²

External Ids
HGNC: 27158¹
Entrez Gene: 150223²
UniProtKB: A8MPS7³
Ensembl: ENSG00000161179⁷

Search outside databases for aliases for YDJC gene

(According to Entrez Gene, Wikipedia's Gene Wiki,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 36),
and/or miRBase,
Genomic Views according to UCSC and Ensembl, Transcription factor binding sites according to SABiosciences)
About This Section

Genomic View:

UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 22q11.21 Ensembl cytogenetic band: 22q11.21 HGNC cytogenetic band: 22q11.21

YDJC Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)

GeneLoc gene densities for chromosome 22 GeneLoc Exon Structure

GeneLoc location for GC22M020312: (about GC identifiers)

Start:	20,312,378 bp from pter
End:	20,314,340 bp from pter
Size:	1,963 bases
Orientation:	minus strand

RefSeq DNA sequence:

NC_000022.9 NT_011520.11

(According to ¹UniProtKB, and/or Ensembl, Phosphorylation sites according to ²Phosphosite, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Enzo Life Sciences, Abnova, OriGene and/or, Abcam,
Biochemical Assays by Invitrogen, Millipore, R&D Systems, Cell Signaling Technology, and/or Enzo Life Sciences, Ontologies according to Gene Ontology Consortium 01 Apr 2009 and Entrez Gene, Antibodies by Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Cell Signaling Technology, Abcam, Abnova, and/or Novus Biologicals)
About This Section

UniProtKB/Swiss-Prot: YDJC_HUMAN, A8MPS7 (See protein sequence)

Recommended Name: UPF0249 protein ydjC homolog

Size: 323 amino acids; 34466 Da

Secondary accessions: Q2YDT4 Q4V9R7

Alternative splicing: 3 isoforms: A8MPS7-1 A8MPS7-2 A8MPS7-3

REFSEQ proteins: NP_001017964.1

ENSEMBL proteins:

ENSP00000381847 ENSP00000292778

Human Recombinant Proteins

	Browse Drug Discovery Central at Invitrogen for human recombinant proteins
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	Browse Abcam for Recombinant Proteins
	Browse Abnova for Human Recombinant Proteins

Browse Origene for full length recombinant human proteins expressed in human HEK293 cells

Antibodies for YDJC:

	Browse Antibodies Central at Invitrogen
	Browse Millipore's Extensive Line of Mono- and Polyclonal Antibodies
	Browse Antibodies at Sigma-Aldrich
	Browse R&D Systems for Antibodies
	Search for antibodies at Abcam and the World's Antibody Gateway (free search engine of over 150 antibody companies)
	Browse Abnova for Monoclonal and Polyclonal Antibodies
	Search Novus for antibodies for YDJC

Assays for YDJC:

	Browse Invitrogen for biochemical assays
	Browse Kits and Assays available from Millipore
	Browse R&D Systems for biochemical assays
	Browse biochemical assays available from Enzo Life Sciences

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

Graphical View of Domain Structure for InterPro Entry A8MPS7

ProtoNet protein and cluster: A8MPS7

UniProtKB/Swiss-Prot: YDJC_HUMAN, A8MPS7

Similarity: Belongs to the UPF0249 family

(According to MGI Jun 06 2009, UniProtKB, IUBMB,and/or Genatlas,
shRNA from OriGene, Sigma-Aldrich, RNAi from Sigma-Aldrich,
RNAi Products, Clones, and Q-PCR Products from Invitrogen, Millipore, OriGene, and/or Abnova, siRNAs from Applied Biosystems, SYBR primers from OriGene, Cell-based Assays from Millipore, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
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Inhib. RNA:		Invitrogen RNAi Products for gene knock-down (YDJC)
		Browse for Gene Knock-down Tools from Millipore
		Browse Abnova for Chimera RNAi Products

OriGene 29mer shRNA kit in GFP-retroviral vectors (see all 3): NM_001017965

Applied Biosystems Silencer® siRNAs for YDJC

Sigma-Aldrich siRNA for YDJC

Sigma-Aldrich shRNA for YDJC

Explore Sigma-Aldrich super-pooled esiRNAs

Clones:		Browse Clone Ranger at Invitrogen for clones
		Browse Clones for the Expression of Recombinant Proteins Available from Millipore

OriGene GFP tagged cDNA clone in CMV expression vector: NM_001017964
Myc/DDK tagged cDNA clone in CMV expression vector: NM_001017964
untagged cDNA clone in CMV expression vector: NM_001017964

Primers:

Browse Quantitative PCR Central at Invitrogen for Q-PCR LUX™ Primers

OriGene genome-wide validated SYBR primer pairs: NM_001017964

1 MGI phenotypic allele

for Ydjc (no phenotypes)

(Pathways according to Invitrogen (maps by GeneGo), Millipore, Cell Signaling Technology, Sigma-Aldrich, KEGG and/or UniProtKB,
Sets of similar genes according to GeneDecks, Proteins Network according to SABiosciences, Interactions according to ¹UniProtKB, ²MINT, and/or ³STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
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(Chemical Compounds according to UniProtKB, Enzo Life Sciences, Sigma-Aldrich, Tocris Bioscience, and/or Novoseek and Drugs according to Enzo Life Sciences and/or PharmGKB)
About This Section

Browse drugs & compounds from Enzo Life Sciences

Browse Small Molecules at Sigma-Aldrich

Browse Tocris compounds for YDJC

(GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 219 Homo sapiens; Jun 2 2009) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView,
non coding RNAs according to RNAdb,
ESTs according to GeneTide,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from Invitrogen, Millipore, and/or Abnova,
siRNAs from Applied Biosystems, Sigma-Aldrich,
shRNA from Sigma-Aldrich, OriGene,
Tagged/untagged cDNA clones from OriGene,
Expression Assays from Applied Biosystems)
About This Section

Inhib. RNA:		Invitrogen RNAi Products for gene knock-down (YDJC)
		Browse for Gene Knock-down Tools from Millipore
		Browse Abnova for Chimera RNAi Products

OriGene 29mer shRNA kit in GFP-retroviral vectors (see all 3): NM_001017965

Sigma-Aldrich siRNA for YDJC

Sigma-Aldrich shRNA for YDJC

Explore Sigma-Aldrich super-pooled esiRNAs

Applied Biosystems Silencer® siRNAs:

NM_001017964

REFSEQ mRNAs for YDJC gene:

NM_001017964.1

Applied Biosystems TaqMan ® Gene Expression Assays:

NM_001017964

              OriGene GFP tagged cDNA clone in CMV expression vector: NM_001017964
                                 Myc/DDK tagged cDNA clone in CMV expression vector: NM_001017964
                                 untagged cDNA clone in CMV expression vector: NM_001017964

Additional cDNA sequence:

BC053663.1 BC057814.1 BC110075.1 BC110799.1 BC133043.1 BC133047.1 CR590781.1 CR594858.1

CR596616.1 CR597037.1 CR600451.1 CR611449.1 CR613078.1 CR613432.1 CR614195.1 CR618402.1

CR620409.1 CR624561.1

14 DOTS entries:

DT.412232 DT.92462297 DT.101982274 DT.100821877 DT.97771308 DT.95133953 DT.100821876 DT.100821875

DT.75140188 DT.100692072 DT.100803936 DT.100833796 DT.95133954 DT.95133976

24/199 AceView cDNA sequences (see all 199 ):

CR611449 BX384302 CR597037 CR613078 CR600451 BM920756 BM851387 CR596616

CR624561 CR620409 AI221458 AI471630 BM273290 AI656234 BM052966 AI083906

BU631753 BM273054 BI907254 CR613432 BM761651 BX326782 BU857339 BE791432

Unigene Cluster for YDJC:

YdjC homolog (bacterial)

Hs.355952 [show with all ESTs]

Unigene Representative Sequence: BM906422

GeneLoc Exon Structure

5/11 Alternative Splicing Database (ASD) splice patterns (SP) for YDJC (see all 11 )

ExUns:	1a	·	1b	·	1c	·	1d	·	1e	^	2a	·	2b	^	3	^	4a	·	4b	·	4c	·	4d	^	5a	·	5b	·	5c	·	5d	·	5e	·	5f
SP1:
SP2:													-
SP3:													-				-		-		-		-
SP4:											-		-
SP5:																	-		-		-		-

About this scheme

ECgene alternative splicing isoforms for YDJC

2 Ensembl transcripts including schematic representations:

ENST00000398873 ENST00000292778

(Experimental results according to ¹GeneNote and GNF BioGPS,
probe sets-to-genes annotations according to ²GeneAnnot , ³GeneTide , Sets of similar genes according to GeneDecks, Electronic Northern calculations according to data from UniGene (Build 219 Homo sapiens), SAGE tags according to CGAP, plus additional links to SOURCE, and/or GNF BioGPS, and/or EXPOLDB, and/or UniProtKB,
Expression Assays from Applied Biosystems )
About This Section

YDJC expression in normal and diseased human tissues

Applied Biosystems TaqMan ® Gene Expression Assays for YDJC

¹ / ²

4 probe-sets matching YDJC gene

Affymetrix probe-set	Array	# genes	Sensitivity	Specificity	Correlation	Length	Gb_Accession	Consensus	Uniqueness	Score	Rank
Affymetrix probe-set	Array	GeneAnnot data			GeneNote data		GeneTide data
44559_at²	U95-B	1	1.00	1.00	0.99	1.18	--	--	--	--	--
89614_r_at²	U95-D	1	0.62	1.00	0.69	0.83	--	--	--	--	--
227042_at²	U133-B	1	0.91	1.00	--	--	--	--	--	--	--
227042_at²	U133Plus2	1	0.91	1.00	--	--	--	--	--	--	--

GeneDecks YDJC for binary patterns associated with the probe-sets selected above

About GeneDecksing

About this table

Data from

(Publications) and GNF BioGPS
About these images
About these images

CGAP SAGE TAG: TTGCAATGCA

SOURCE GeneReport for Unigene cluster: Hs.355952

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD and/or ⁵MGI Jun 06 2009, with possible further links to Flybase and/or WormBase, Gene Trees according to Ensembl)
About This Section

Orthologs for YDJC gene from 5/6 species (see all 6 )

Organism	Gene	Locus	Description	Human Similarity	NCBI accessions
cow (Bos taurus)	YDJC¹	--	YdjC homolog (bacterial)	83.8(n) 84.11(a)	538763 XM_582517.3 XP_582517.2
rat (Rattus norvegicus)	Ydjc¹	--	YdjC homolog (bacterial)	83.26(n) 88.48(a)	287938 NM_001013863.1 NP_001013885.1
mouse (Mus musculus)	Ydjc^{1, 5}	16⁵	YdjC homolog (bacterial)^{1, 5}	84.03(n)¹ 89.64(a)¹	69101¹ NM_026940.2¹ NP_081216.1¹ AI426121⁵ AK007503⁵ (see all 13)
chicken (Gallus gallus)	YDJC¹	--	YdjC homolog (bacterial)	58.36(n) 55.63(a)	771088 XM_001234390.1 XP_001234391.1
zebrafish (Danio rerio)	CH211-89F7.6¹	--	hypothetical LOC569036	55.89(n) 50.51(a)	569036 NM_001082862.1 NP_001076331.1

About this table Species with no ortholog for YDJC

ENSEMBL Gene Tree for YDJC

(Paralogs according to ¹HomoloGene
and ²Ensembl, Pseudogenes according to ³Pseudogene.org)
About This Section

(According to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, and UniProtKB, Linkage Disequilibrium by HapMap, Genotyping Reagents from Applied Biosystems)
About This Section

10/26 NCBI SNPs in YDJC are shown (see all 26 )
(Click for Applied Biosystems TaqMan ® Genotyping Assay) (see all 43)

AB	SNP ID	Valid	Chr 22 pos	Sequence	Recs	AA Chg	Type	More	Recs	Allele freq	Pop	Total sample	More
AB	Genomic Data				Transcription Data				Allele Frequencies
				--	--	--		--	--				--
	rs861857^1,2	A,C,F,H	20312340(+)	`TTTCTG/CTGAGG`	1	--	ng5¹		17		EA NA NS EU WA	1122
	rs878825^1,2	A,C,F,H	20312249(-)	`GCTGCA/GATTTT`	1	--	ng5¹		12		NA EA NS EU WA	758
--	rs3747093^1,2	A,C,F	20314379(+)	`tgcccG/Aggccc`	1	--	ng3¹		1		EA	1478
	rs2298428^1,2	C,F,H	20312892(+)	`GAAAGC/TGTCGG`	1	A/T	mis¹ ese³		4		EU EA WA	418
--	rs1811069^1,2	A,C	20312054(+)	`cagacG/Tggtct`	1	--	ng5¹		0	--	--	--	--
--	rs11704601^1,2	A,C	20314568(+)	`CAAAAA/GGAagc`	1	--	ng3¹		0	--	--	--	--
	rs1046843^1,2	F	20312432(-)	`TCACCA/CCTGGG`	1	--	ut3¹ ese³		1		MN	184
	rs710177^1,2	C,F	20314205(+)	`GTCACA/GGCCCC`	1	A/A	syn¹ ese³		1		MN	184
	rs2298429^1,2	A,C,F,H	20313260(+)	`GGGACA/GGAGGC`	1	--	int¹		4		EU EA WA	418
	rs3747091^1,2	C,F,H	20313766(+)	`CTTCCG/ATGTGA`	1	--	int¹		6		EA EU WA	2058

About this table

HapMap Linkage Disequilibrium images for YDJC (up to first 250kb)

(in which this Gene is Involved, According to OMIM, UniProtKB, PharmGKB, Genatlas, GeneTests, Blood group antigen gene mutations by BGMUT, HGMD, GAD, HuGE Navigator, BCGD, and/or TGDB.)
About This Section

(Possibly Related Articles in Doctor's Guide)
About This Section

(in PubMed. Associations of this gene to articles via ¹Novoseek, ²HGNC, ³Entrez Gene, ⁴UniProtKB/Swiss-Prot, ⁵UniProtKB/TrEMBL, ⁶GAD, and/or ⁷PharmGKB)
About This Section

4 PubMed articles for YDJC gene:

Crystal structure of the YdjC-family protein TTHB029 from Thermus thermophilus HB8: structural relationship with peptidoglycan N-acetylglucosamine deacetylase. (PubMed id 18177738)^{2, 3} Imagawa T....Tsuge H. (2008)
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)⁴ Gerhard D.S....Malek J. (2004)
Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)³ Strausberg R.L....Marra M.A. (2002)
The DNA sequence of human chromosome 22. (PubMed id 10591208)⁴ Dunham I....O'Brien K.P. (1999)

(in PubMed, OMIM, and NCBI Bookshelf)
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		AND	OR
Aliases
Free Text

Query String		PubMed OMIM NCBI Bookshelf
	(Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, and/or H-InvDB)
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Entrez Gene: 150223	HGNC: 27158	AceView: LOC150223	Ensembl:ENSG00000161179	euGenes: HUgn150223
ECgene: YDJC	H-InvDB: YDJC

(According to HUGE)
About This Section

(According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section

Licensable Technologies for YDJC
(Available from WIS Yeda, Salk, Tufts)

About This Section

(Reagents available from Applied Biosystems, Antibodies and assays by Cell Signaling Technology, Abcam, Novus Biologicals,
Sigma-Aldrich, R&D Systems, Millipore, Abnova, and/or Invitrogen, Clones available from OriGene,and/or Invitrogen, Drugs and/or compounds by Sigma-Aldrich,
Enzo Life Sciences, and/or Tocris Bioscience)
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Products for YDJC:

TaqMan ® Gene Expression Assays

TaqMan ® Genotyping Assays

Free SNP selection tool

Invitrogen iPath Pathways	Invitrogen BLOCK-iT™ RNAi
Invitrogen Antibodies	Invitrogen Assays
Invitrogen Clones	Invitrogen Q-PCR Products
Invitrogen Human Recombinant Kinases	Invitrogen Custom Antibody and Peptide Service
Invitrogen Proteins / Assays / Screening Services	Search Invitrogen catalog for YDJC-related products

	Millipore Custom Antibody & Bulk Services
	Millipore Preclinical / Clinical Development Services
	Millipore Immunoassay Services
	Millipore Target Screening & Profiling Services

	Predesigned and custom siRNAs for YDJC		Browse antibodies at Sigma-Aldrich
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	Lentivirus-delivered shRNAs for YDJC		Browse small molecules at Sigma-Aldrich
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	Multiplex/Array Assay Kits & Reagents		ELISpot Kits & Development Modules
	Recombinant & Natural Proteins

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	Custom Service for Rabbit Pab from Full-length Protein

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Search OriGene for YDJC

Search Tocris compounds for YDJC

Search www.enzolifesicences.com for proteins, assays, substrates, inhibitors & antibodies

Search Novus for antibodies for YDJC

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YDJC Gene

protein-coding GIFtS: 38

Aliases &
Descriptions
for YDJC

Summaries
for YDJC

Genomic Location
for YDJC

Proteins
for YDJC

Protein Domains/
Families
for YDJC

Gene Function
for YDJC

Pathways & Interactions
for YDJC

Drugs & Compounds
for YDJC

Transcripts
for YDJC

Expression
for YDJC

Orthologs
for YDJC

Paralogs
for YDJC

SNPs/Variants
for YDJC

Disorders & Mutations
for YDJC

Medical News
for YDJC

Publications
for YDJC

Search for YDJC

Genome Databases showing YDJC

Other Databases showing YDJC

Specialized Databases showing YDJC

Licensable Technologies
for YDJC

Services
for YDJC

Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

YDJC Gene

protein-coding GIFtS: 38

Aliases & Descriptionsfor YDJC

Summariesfor YDJC

Genomic Locationfor YDJC

Proteinsfor YDJC

Protein Domains/Familiesfor YDJC

Gene Functionfor YDJC

Pathways & Interactionsfor YDJC

Drugs & Compoundsfor YDJC

Transcriptsfor YDJC

Expression for YDJC

Orthologsfor YDJC

Paralogsfor YDJC

SNPs/Variantsfor YDJC

Disorders & Mutationsfor YDJC

Medical Newsfor YDJC

Publicationsfor YDJC

Search for YDJC

Genome Databases showing YDJC

Other Databases showing YDJC

Specialized Databases showing YDJC

Licensable Technologiesfor YDJC

Servicesfor YDJC

Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

Aliases &
Descriptions
for YDJC

Summaries
for YDJC

Genomic Location
for YDJC

Proteins
for YDJC

Protein Domains/
Families
for YDJC

Gene Function
for YDJC

Pathways & Interactions
for YDJC

Drugs & Compounds
for YDJC

Transcripts
for YDJC

Expression
for YDJC

Orthologs
for YDJC

Paralogs
for YDJC

SNPs/Variants
for YDJC

Disorders & Mutations
for YDJC

Medical News
for YDJC

Publications
for YDJC

Licensable Technologies
for YDJC

Services
for YDJC