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YBX3 Gene

protein-coding   GIFtS: 50
GCID: GC12M010852

Y Box Binding Protein 3

(Previous name: cold shock domain protein A)
(Previous symbol: CSDA)
  Search for YBX3
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Y Box Binding Protein 31 2     DNA-Binding Protein A2 3
CSDA1 2 3 5     CSDA12
DBPA2 3 5     ZONAB2
Cold Shock Domain Protein A1 2     Cold-Shock Domain Protein A2
Cold-Shock Domain Containing A11 2     Y-Box-Binding Protein 32
Cold Shock Domain-Containing Protein A2 3     ZO-1-Associated Nucleic Acid-Binding Protein2
Single-Strand DNA-Binding Protein NF-GMB2 3     

External Ids:    HGNC: 24281   Entrez Gene: 85312   Ensembl: ENSG000000601387   OMIM: 6034375   UniProtKB: P169893   

Export aliases for YBX3 gene to outside databases


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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GeneCards Summary for YBX3 Gene:
YBX3 (Y box binding protein 3) is a protein-coding gene. GO annotations related to this gene include double-stranded DNA binding and sequence-specific DNA binding transcription factor activity. An important paralog of this gene is YBX2.

UniProtKB/Swiss-Prot: YBOX3_HUMAN, P16989
Function: Binds to the GM-CSF promoter. Seems to act as a repressor. Binds also to full length mRNA and to short
RNA sequences containing the consensus site 5'-UCCAUCA-3'. May have a role in translation repression (By
similarity)

Gene Wiki entry for YBX3 (CSDA) Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000012.11  NC_018923.2  NT_009714.18  
Regulatory elements:
   Search for regulatory transcription factor binding sites for YBX3
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidYBX3 promoter sequence
   Search Chromatin IP Primers for YBX3

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat YBX3


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 12p13.1   Ensembl cytogenetic band:  12p13.2   HGNC cytogenetic band: 12p13.1

YBX3 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
YBX3 gene location

GeneLoc information about chromosome 12         GeneLoc Exon Structure

GeneLoc location for GC12M010852:  view genomic region     (about GC identifiers)

Start:
10,851,676 bp from pter      End:
10,875,953 bp from pter
Size:
24,278 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., and/or eBioscience,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., and/or eBioscience, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: YBOX3_HUMAN, P16989 (See protein sequence)
Recommended Name: Y-box-binding protein 3  
Size: 372 amino acids; 40090 Da
Subunit: Found in a mRNP complex with YBX2 (By similarity)
Sequence caution: Sequence=AAA35749.1; Type=Erroneous initiation; Note=Translation N-terminally shortened;
Secondary accessions: B2RBW6 Q14121 Q969N6 Q96B76
Alternative splicing: 3 isoforms:  P16989-1   P16989-2   P16989-3   

Explore the universe of human proteins at neXtProt for YBX3: NX_P16989

Explore proteomics data for YBX3 at MOPED

Post-translational modifications: 

  • Ubiquitination2 at Lys90, Lys96, Lys113, Lys124, Lys125, Lys268
  • Modification sites at PhosphoSitePlus

  • See YBX3 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (2 alternative transcripts): 
    NP_001138898.1  NP_003642.3  

    ENSEMBL proteins: 
     ENSP00000279550   ENSP00000228251   ENSP00000441447  

    YBX3 Human Recombinant Protein Products:

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    Novus Biologicals YBX3 Protein
    Novus Biologicals YBX3 Lysate
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates
    Browse ProSpec Recombinant Proteins
    Browse Proteins at Cloud-Clone Corp.

     
    Search eBioscience for Proteins for YBX3 

    YBX3 Antibody Products:

    EMD Millipore Mono- and Polyclonal Antibodies for the study of YBX3
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    ThermoFisher Antibodies for YBX3
    LSBio Antibodies in human, mouse, rat for YBX3

    YBX3 Assay Products:

    Browse Kits and Assays available from EMD Millipore
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    Browse Enzo Life Sciences for kits & assays
    Browse ELISAs at Cloud-Clone Corp.
    Browse CLIAs at Cloud-Clone Corp.
    Search eBioscience for ELISAs for YBX3 


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    4 InterPro protein domains:
     IPR019844 Cold-shock_CS
     IPR012340 NA-bd_OB-fold
     IPR011129 Cold_shock_prot
     IPR002059 CSP_DNA-bd

    Graphical View of Domain Structure for InterPro Entry P16989

    ProtoNet protein and cluster: P16989

    2 Blocks protein domains:
    IPB002059 Cold-shock DNA-binding domain
    IPB011129 Cold shock protein


    UniProtKB/Swiss-Prot: YBOX3_HUMAN, P16989
    Similarity: Contains 1 CSD (cold-shock) domain


    Find genes that share domains with YBX3           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: YBOX3_HUMAN, P16989
    Function: Binds to the GM-CSF promoter. Seems to act as a repressor. Binds also to full length mRNA and to short
    RNA sequences containing the consensus site 5'-UCCAUCA-3'. May have a role in translation repression (By
    similarity)

         Gene Ontology (GO): Selected molecular function terms (see all 10):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003676nucleic acid binding ----
    GO:0003677DNA binding ----
    GO:0003690double-stranded DNA binding TAS2977358
    GO:0003697single-stranded DNA binding IEA--
    GO:0003700sequence-specific DNA binding transcription factor activity NAS8710501
         
    Find genes that share ontologies with YBX3           About GenesLikeMe


    Phenotypes:
         6 MGI mutant phenotypes (inferred from 1 allele(MGI details for Csda):
     embryogenesis  endocrine/exocrine gland  growth/size/body  mortality/aging  nervous system 
     reproductive system 

    Find genes that share phenotypes with YBX3           About GenesLikeMe

    Animal Models:
         MGI mouse knock-out Ybx3tm1Ley for YBX3

       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for YBX3
       inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for YBX3

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    miRNA
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    miRTarBase miRNAs that target YBX3:
    hsa-mir-30a-5p (MIRT028402), hsa-mir-18a-5p (MIRT050665), hsa-mir-124-3p (MIRT022125), hsa-mir-100-5p (MIRT048561), hsa-mir-652-3p (MIRT039503), hsa-mir-155-5p (MIRT020521), hsa-mir-16-5p (MIRT031397), hsa-mir-92a-3p (MIRT049114), hsa-mir-193b-3p (MIRT041350)

    Block miRNA regulation of human, mouse, rat YBX3 using miScript Target Protectors
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    SwitchGear 3'UTR luciferase reporter plasmidYBX3 3' UTR sequence
    Inhib. RNA
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    Predesigned siRNA for gene silencing in human, mouse, rat YBX3

    Gene Editing
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    Sino Biological Human cDNA Clone for YBX3
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    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat YBX3

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    Browse ESI BIO Cell Lines and PureStem Progenitors for YBX3 
    In Situ Assay
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for YBX3


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    YBOX3_HUMAN, P16989: Cytoplasm. Nucleus

    Gene Ontology (GO): Selected cellular component terms (see all 6):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus ISS--
    GO:0005737cytoplasm IDA--
    GO:0005844polysome IEA--
    GO:0005923tight junction ISS--
    GO:0030529ribonucleoprotein complex ----

    Find genes that share ontologies with YBX3           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for YBX3 About    
    See pathways by source

    SuperPathContained pathways About
    1Cell adhesion Integrin mediated cell adhesion and migration
    Cell adhesion Tight junctions0.33
    2Tight junction
    Tight junction
    3RalA downstream regulated genes
    RalA downstream regulated genes


    Find genes that share SuperPaths with YBX3           About GenesLikeMe

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    2 Downloadable PowerPoint Slides of GeneGlobe Pathway Central Maps for YBX3
        Sertoli-Sertoli Cell Junction Dynamics
    Epithelial Tight Junctions

    1 GeneGo (Thomson Reuters) Pathway for YBX3
        Cell adhesion Tight junctions

    1 BioSystems Pathway for YBX3
        RalA downstream regulated genes



    1 Kegg Pathway  (Kegg details for YBX3):
        Tight junction

        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for YBX3
    Interactions:

        Search GeneGlobe Interaction Network for YBX3

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for YBX3 (P169892, 3 ENSP000002282514) via UniProtKB, MINT, STRING, and/or I2D (see all 653)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    GSK3BP498412, 3, ENSP000003248064MINT-65985 MINT-65984 I2D: score=3 STRING: ENSP00000324806
    MAPK1P284822, 3, ENSP000002158324MINT-65981 MINT-65988 I2D: score=3 STRING: ENSP00000215832
    SRRM1Q8IYB32, 3, ENSP000003262614MINT-7945693 I2D: score=1 STRING: ENSP00000326261
    MAP3K14Q995582, 3MINT-48864 I2D: score=2 
    NSFP464592, 3MINT-7945693 I2D: score=1 
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 18):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000122negative regulation of transcription from RNA polymerase II promoter TAS8710501
    GO:0001701in utero embryonic development IEA--
    GO:0006351transcription, DNA-templated IEA--
    GO:0006355regulation of transcription, DNA-templated ----
    GO:0007283spermatogenesis IEA--

    Find genes that share ontologies with YBX3           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for YBX3 (YBOX3)

    4 Novoseek inferred chemical compound relationships for YBX3 gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    dbpa 99 199 16243807 (9), 19749785 (9), 7628487 (8), 7651426 (8) (see all 41)
    hydrogen 26.5 4 10716181 (2), 15162492 (1), 11262979 (1)
    lysine 5.42 4 10473582 (3)
    vegf 0 4 16198352 (2), 12433987 (2)



    Find genes that share compounds with YBX3           About GenesLikeMe



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for YBX3 gene (2 alternative transcripts): 
    NM_001145426.1  NM_003651.4  

    Unigene Cluster for YBX3:

    Y box binding protein 3
    Hs.221889  [show with all ESTs]
    Unigene Representative Sequence: NM_003651
    18 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000279550(uc001qyu.3) ENST00000228251(uc001qyt.3) ENST00000540447
    ENST00000540975 ENST00000546164 ENST00000536823 ENST00000366286 ENST00000542002
    ENST00000366290 ENST00000542641 ENST00000541351 ENST00000544504 ENST00000539204
    ENST00000544622 ENST00000546298 ENST00000544501 ENST00000536107 ENST00000540747

    miRNA
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    Primer
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      QuantiTect SYBR Green Assays in human, mouse, rat YBX3
      QuantiFast Probe-based Assays in human, mouse, rat YBX3

    Additional mRNA sequence: 

    AK314846.1 BC008801.2 BC009744.2 BC015564.1 BC015913.1 BC021926.1 BC150580.1 M24069.1 
    X72712.1 X95325.1 

    Selected DOTS entries (see all 37):

    DT.319993  DT.97864614  DT.100882846  DT.100882850  DT.97864619  DT.97864621  DT.40129259  DT.91660185 
    DT.100882853  DT.121173921  DT.95191600  DT.100882854  DT.95123479  DT.121173945  DT.319996  DT.95105476 
    DT.97767540  DT.97864618  DT.100727984  DT.121173905  DT.100882852  DT.121173924  DT.40306924  DT.95191544 

    Selected AceView cDNA sequences (see all 784):

    AA609157 BF970950 AJ711267 AI379686 T39328 BM714179 AI004865 BQ901048 
    CD724235 BQ958734 AI081577 BF516397 BG697269 CD723364 T39284 AA382137 
    C03891 CB132889 BM551303 BQ436176 AA455300 AW189293 AI763104 AU185835 

    GeneLoc Exon Structure

    Selected Alternative Splicing Database (ASD) splice patterns (SP) for YBX3 (see all 12)    About this scheme

    ExUns: 1a · 1b ^ 2 ^ 3 ^ 4 ^ 5a · 5b ^ 6a · 6b · 6c ^ 7a · 7b ^ 8 ^ 9 ^ 10a · 10b ^ 11a · 11b · 11c ^ 12a · 12b ^ 13 ^ 14a · 14b · 14c
    SP1:              -     -                 -     -                       -     -                       -     -     -     -                                 
    SP2:              -     -                 -     -                       -     -     -                 -     -     -     -                                 
    SP3:                                                                    -     -     -                 -     -     -     -                                 
    SP4:                                                                                                              -     -                                 
    SP5:                                                                                            -     -     -     -     -                                 


    ECgene alternative splicing isoforms for YBX3

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    YBX3 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: --
    YBX3 Expression
    About this image

    YBX3 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    YBX3 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.221889

    UniProtKB/Swiss-Prot: YBOX3_HUMAN, P16989
    Tissue specificity: Highly expressed in skeletal muscle and heart

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    In Situ
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for YBX3

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of animals.

    Orthologs for YBX3 gene from Selected species (see all 14)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Csda5
    Ybx31
    cold shock domain protein A5
    Y box protein 31
    86.89(n)1
    86.43(a)1
      6 (63.44 cM)5
    564491  NM_139117.21  NP_620817.21 
     1313648585 
    chicken
    (Gallus gallus)
    Aves CSDA1 cold shock domain protein A 74.26(n)
    76.24(a)
      396371  NM_205406.1  NP_990737.1 
    African clawed frog
    (Xenopus laevis)
    Amphibia M80257.12   -- 81.99(n)    M80257.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta yps6
    ypsilon schachtel
    34(a)
    1 → many
    3L(12114374-12118250)
    worm
    (Caenorhabditis elegans)
    Secernentea cey-16
    cey-46
    (see all 4)
    Protein CEY-4 (cey-4) mRNA, complete cds
    (see all 4)
    44(a)
    31(a)
    (see all 4)
    many ↔ many
    many ↔ many
    (see all 4)
    II(11039449-11041206) WBGene00000472
    III(10866946-10868727) WBGene00000475


    ENSEMBL Gene Tree for YBX3 (if available)
    TreeFam Gene Tree for YBX3 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for YBX3 gene
    YBX22  YBX12  
    2 SIMAP similar genes for YBX3 using alignment to 2 protein entries:     YBOX3_HUMAN (see all proteins):
    YBX1    YBX2

    Find genes that share paralogs with YBX3           About GenesLikeMe


    1 Pseudogenes.org Pseudogene for YBX3
    PGOHUM00000248811


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for YBX3 (see all 602)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 12 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs123106011,2
    C,F,H--10851178(+) CACAAA/GCCTAC 2 -- int114Minor allele frequency- G:0.28NS EA NA CSA WA 919
    rs44457271,2
    C,F,A,H--10851226(+) CTATAC/TGGCAC 2 -- int114Minor allele frequency- T:0.12NS EA NA CSA WA 909
    rs730446371,2
    C--10851303(+) AAAGAG/ACTCCC 2 -- int15Minor allele frequency- A:0.12NA CSA WA EA 361
    rs1453684861,2
    --10851405(+) GTCATC/TACGTC 2 -- int10--------
    rs1172921441,2
    --10851407(+) CATCAC/TGTCAC 2 -- int11Minor allele frequency- T:0.01NA 120
    rs1506323921,2
    C--10851624(+) TAAATA/CAAGTG 2 -- int10--------
    rs21660661,2
    C,F,O,H--10851658(+) AGGTCA/GGCAAA 2 -- int120Minor allele frequency- T:0.01NS EA NA 2428
    rs1397863891,2
    --10851722(+) AGGAAC/TTTCTT 2 -- ut310--------
    rs72701,2
    C,F,O,A,H--10851772(+) ATGTTA/TTCCTC 2 -- ut315Minor allele frequency- T:0.29MN NA 378
    rs1821611881,2
    C--10851786(+) TCATCC/TTAGAA 2 -- ut310--------

    HapMap Linkage Disequilibrium report for YBX3 (10851676 - 10875953 bp)

    Structural Variations
          Database of Genomic Variants (DGV) variations for YBX3: --
    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing YBX3
    DNA2.0 Custom Variant and Variant Library Synthesis for YBX3

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 603437    OMIM disorders: --


    Find genes that share disorders with YBX3           About GenesLikeMe

    6 Novoseek inferred disease relationships for YBX3 gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    lyme neuroborreliosis 79.6 1 14648148 (1)
    lyme disease 72.4 4 16081885 (1), 10473582 (1), 11825956 (1), 10650211 (1)
    lyme arthritis 66.8 2 12792865 (1), 18279004 (1)
    shock 48.2 16 10716181 (2), 11262979 (2), 10518954 (1), 17661445 (1) (see all 13)
    hepatocellular carcinoma 17 16 16243807 (7), 16865284 (1), 15313206 (1)
    carcinoma 0 1 16508013 (1)


    Export disorders for YBX3 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for YBX3 gene, integrated from 10 sources (see all 126):
    (articles sorted by number of sources associating them with YBX3)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Cold shock domain proteins repress transcription from the GM-CSF promoter. (PubMed id 8710501)1, 2, 3 Coles L.S.... Shannon M.F. (Nucleic Acids Res. 1996)
    2. Two human genes isolated by a novel method encode DNA-binding proteins containing a common region of homology. (PubMed id 2977358)1, 2, 3 Sakura H.... Ishii S. (Gene 1988)
    3. Characterization of the gene for dbpA, a family member of the nucleic-acid-binding proteins containing a cold-shock domain. (PubMed id 7628487)1, 2, 9 Kudo S.... Fukuda M. (Eur. J. Biochem. 1995)
    4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    5. Upregulation of human DNA binding protein A (dbpA) in gastric cancer cells. (PubMed id 19749785)1, 9 Wang G.R....He D.L. (Acta Pharmacol. Sin. 2009)
    6. Transcription of dbpA, a Y box binding protein, is positively regulated by E2F1: implications in hepatocarcinogenesis. (PubMed id 15313206)1, 9 Arakawa Y....Hino O. (Biochem. Biophys. Res. Commun. 2004)
    7. Somatic mutation and SNP in the promoter of dbpA and human hepatocarcinogenesis. (PubMed id 12239625)1, 9 Hayashi J....Hino O. (Int. J. Oncol. 2002)
    8. Phosphorylation of cold shock domain/Y-box proteins by ERK2 and GSK3beta and repression of the human VEGF promoter. (PubMed id 16198352)1, 9 Coles L.S....Goodall G.J. (FEBS Lett. 2005)
    9. Regulation of PCNA and cyclin D1 expression and epithelial morphogenesis by the ZO-1-regulated transcription factor ZONAB/DbpA. (PubMed id 16508013)1, 9 Sourisseau T....Balda M.S. (Mol. Cell. Biol. 2006)
    10. The intracellular interactome of tetraspanin-enriched microdomains reveals their function as sorting machineries toward exosomes. (PubMed id 23463506)1 Perez-Hernandez D....YA!A+ez-MA^ M. (J. Biol. Chem. 2013)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 8531 HGNC: 2428 AceView: CSDA Ensembl:ENSG00000060138 euGenes: HUgn8531
    ECgene: YBX3 Kegg: 8531 H-InvDB: YBX3

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for YBX3 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for YBX3 gene:
    Search GeneIP for patents involving YBX3

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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