Set Analyses:
Advanced Search

Advanced Search

 
Search By
Section (entire)
for


 
or upload a file of gene symbols


Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

YBX2 Gene

protein-coding   GIFtS: 51
GCID: GC17M007191

Y box binding protein 2
 Explore 7 diseases affiliated with
YBX2 via
MalaCards
our new
 Human Malady Compendium 
Biological research products
for YBX2    

Aliases
for YBX2 gene

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, and/or 10fRNAdb)
About This Section
Aliases
Y Box Binding Protein 21 2     CONTRIN2
CSDA31 2 3     DBPC2
MSY21 2 3     Germ Cell Specific Y-Box Binding Protein2
Germ Cell-Specific Y-Box-Binding Protein2 3     Y-Box-Binding Protein 22
DNA-Binding Protein C2 3     Contrin3
MSY2 Homolog2 3     Dbpc3

External Ids:    HGNC: 179481   Entrez Gene: 510872   Ensembl: ENSG000000060477   OMIM: 6114475   UniProtKB: Q9Y2T73   

Export aliases for YBX2 gene to outside databases

Previous GC identifers: GC17M007549 GC17M007921 GC17M007134 GC17M007392 GC17M007132 GC17M007083


Summaries
for YBX2 gene

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section
Entrez Gene summary for YBX2:
This gene encodes a nucleic acid binding protein which is highly expressed in germ cells. The encoded protein binds to
a Y-box element in the promoters of certain genes but also binds to mRNA transcribed from these genes. Pseudogenes for
this gene are located on chromosome 10 and 15. (provided by RefSeq, Feb 2012)

UniProtKB/Swiss-Prot: YBOX2_HUMAN, Q9Y2T7
Function: Major constituent of messenger ribonucleoprotein particles (mRNPs). Involved in the regulation of the
stability and/or translation of germ cell mRNAs. Binds to Y-box consensus promoter element. Binds to full length mRNA
with high affinity in a sequence-independent manner. Binds to short RNA sequences containing the consensus site
5'-UCCAUCA-3' with low affinity and limited sequence specificity. Its binding with maternal mRNAs is necessary for its
cytoplasmic retention. May mark specific mRNAs (those transcribed from Y-box promoters) in the nucleus for cytoplasmic
storage, thereby linking transcription and mRNA storage/translational delay (By similarity)

Gene Wiki entry for YBX2


Genomic Views
for YBX2 gene

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000017.10  NC_018928.1  NT_010718.16  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the YBX2 gene promoter:
         AREB6   C/EBPbeta   PPAR-gamma1   COMP1   Nkx2-5   PPAR-gamma2   LCR-F1   Gfi-1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: YBX2 promoter sequence
   Search SABiosciences Chromatin IP Primers for YBX2

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat YBX2


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 17p13.1   Ensembl cytogenetic band:  17p13.1   HGNC cytogenetic band: 17p13.1

YBX2 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
YBX2 gene location

GeneLoc information about chromosome 17         GeneLoc Exon Structure

GeneLoc location for GC17M007191:  view genomic region     (about GC identifiers)

Start:
 7,191,571 bp from pter      End:
 7,197,934 bp from pter
Size:
 6,364 bases      Orientation:
 minus strand

Proteins
for YBX2 gene

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section
UniProtKB/Swiss-Prot: YBOX2_HUMAN, Q9Y2T7 (See protein sequence)
Recommended Name: Y-box-binding protein 2  
Size: 364 amino acids; 38518 Da
Subunit: Found in a mRNP complex with PABPC1 and CSDA (By similarity)
Subcellular location: Cytoplasm. Nucleus
Secondary accessions: D3DTP1 Q8N4P0

Explore the universe of human proteins at neXtProt for YBX2: NX_Q9Y2T7

Post-translational modifications:

  • Phosphorylated during oocyte maturation and dephosphorylated following egg activation. Phosphorylated in vitro by a
    • kinase activity associated with testicular mRNPs. Dephosphorylation leads to a decrease in its affinity to bind RNA in
    vitro (By similarity)1
  • View modification sites using PhosphoSitePlus2
  • View neXtProt modification sites for NX_Q9Y2T7

    • YBX2 Protein expression data from MOPED and PaxDb:    About this image 
    YBX2 Protein Expression
    REFSEQ proteins: NP_057066.2  
    ENSEMBL proteins: 
     ENSP00000007699   ENSP00000459587  

    Human Recombinant Protein Products for YBX2: 
    Browse Purified and Recombinant Proteins at EMD Millipore
    Browse R&D Systems for human recombinant proteins
    Browse recombinant and purified proteins available from Enzo Life Sciences
    Browse OriGene full length recombinant human proteins expressed in human HEK293 cells
    OriGene Protein Over-expression Lysate: YBX2
    OriGene Custom Protein Services for YBX2 
    GenScript Custom Purified and Recombinant Proteins Services for YBX2
    Novus Biologicals YBX2 Proteins
    Novus Biologicals YBX2 Lysates
    Browse Sino Biological Recombinant Proteins
    Browse ProSpec Recombinant Proteins
    Uscn Proteins for YBX2

    Gene Ontology (GO): 4 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus IEA--
    GO:0005737cytoplasm IEA--
    GO:0005844polysome IEA--
    GO:0030529ribonucleoprotein complex ----

    YBX2 for ontologies           About GeneDecksing



    YBX2 Antibody Products: 
    Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
    Browse R&D Systems for Antibodies
    Browse OriGene Antibodies
    OriGene Custom Antibody Services for YBX2 
    GenScript Custom Superior Antibodies Services for YBX2
    Novus Biologicals YBX2 Antibodies
    Abcam antibodies for YBX2 
    Uscn Antibodies for YBX2
    ThermoFisher Antibodies for YBX2

    Assay Products for YBX2: 
    Browse Kits and Assays available from EMD Millipore
    OriGene Custom Immunoassay Development
    Browse OriGene Fluorogenic Cell Assay Kits
    Browse R&D Systems for biochemical assays
    GenScript Custom Assay Services for YBX2
    Browse Enzo Life Sciences for kits & assays
    Uscn ELISAs and CLIAs for YBX2

    Protein Domains /
    Families
    for YBX2 gene

    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    YBX2 for domains           About GeneDecksing

    4 InterPro domains/families:
     IPR019844 Cold-shock_CS
     IPR012340 NA-bd_OB-fold
     IPR011129 Cold_shock_prot
     IPR002059 CSP_DNA-bd

    Graphical View of Domain Structure for InterPro Entry Q9Y2T7

    ProtoNet protein and cluster: Q9Y2T7

    2 Blocks protein families:
    IPB002059 Cold-shock DNA-binding domain
    IPB011129 Cold shock protein


    UniProtKB/Swiss-Prot: YBOX2_HUMAN, Q9Y2T7
    Similarity: Contains 1 CSD (cold-shock) domain


    Function
    for YBX2 gene

    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, Sirion Biotech, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, Sirion Biotech, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
    About This Section
    Molecular Function:

         UniProtKB/Swiss-Prot Summary: YBOX2_HUMAN, Q9Y2T7
    Function: Major constituent of messenger ribonucleoprotein particles (mRNPs). Involved in the regulation of the
    stability and/or translation of germ cell mRNAs. Binds to Y-box consensus promoter element. Binds to full length mRNA
    with high affinity in a sequence-independent manner. Binds to short RNA sequences containing the consensus site
    5'-UCCAUCA-3' with low affinity and limited sequence specificity. Its binding with maternal mRNAs is necessary for its
    cytoplasmic retention. May mark specific mRNAs (those transcribed from Y-box promoters) in the nucleus for cytoplasmic
    storage, thereby linking transcription and mRNA storage/translational delay (By similarity)

         Gene Ontology (GO): 5/7 molecular function terms (GO ID links to tree view) (see all 7):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003677DNA binding IEA--
    GO:0003682chromatin binding IEA--
    GO:0003729mRNA binding ----
    GO:0003730mRNA 3'-UTR binding IEA--
    GO:0008289lipid binding IEA--
         
    YBX2 for ontologies           About GeneDecksing


    Phenotypes:
         2 GenomeRNAi human phenotypes for YBX2:
     Synthetic lethal with Ras  Synthetic lethal with c-Myc af 

         3 MGI mutant phenotypes (inferred from 1 allele) (MGI details for Ybx2):
     cellular  endocrine/exocrine gland  reproductive system 

    YBX2 for phenotypes           About GeneDecksing

    Animal Models:
         Mouse knock-out Ybx2tm1Nbh for YBX2
       inGenious Targeting Laboratory - Customizable classic, inducible, and humanized mouse model solutions for YBX2 

    miRNA
    Products:            		 OriGene 3'-UTR Clone: YBX2
    Browse MicroRNA Expression Plasmids
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat YBX2
    8/34 QIAGEN miScript miRNA Assays for microRNAs that regulate YBX2 (see all 34):
    hsa-miR-2052 hsa-miR-330-5p hsa-miR-218-1* hsa-miR-765 hsa-miR-650 hsa-miR-764 hsa-miR-1243 hsa-miR-326
    SwitchGear 3'UTR luciferase reporter plasmid: YBX2 3' UTR sequence
    Inhib. RNA
    Products:            		Browse for Gene Knock-down Tools from EMD Millipore
    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for YBX2 (see all 4)
    OriGene shRNA RFP: YBX2
    OriGene siRNA: YBX2
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat YBX2
    Sirion Biotech Custom design and validation of potent shRNA sequences against YBX2 

    Gene Editing
    Products:    		DNA2.0 Custom Protein Engineering Service for YBX2
    Sirion Biotech Customized adenovirus for overexpression of YBX2 
    Sirion Biotech Customized adenovirus for potent knockdown of YBX2

    Clone
    Products:             		Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
    OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for YBX2 (see all 2)
    OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for YBX2
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling 
    GenScript: all cDNA clones in your preferred vector: YBX2 (NM_015982)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for YBX2
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat YBX2 

    Cell Line
    Products:             		GenScript Custom overexpressing Cell Line Services for YBX2
    Search LifeMap BioReagents cell lines for YBX2
    Sirion Biotech Customized stable knockdown cell line services for YBX2 
    Sirion Biotech Customized inducible knockdown cell line services for YBX2
    Sirion Biotech Customized stable overexpressing cell line services for YBX2
    Sirion Biotech Customized inducible overexpressing cell line services for YBX2

    In Situ Assay
    Products:       
         		Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for YBX2


    Pathways & Interactions
    for YBX2 gene

    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
    About This Section



    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for YBX2

    STRING Interaction Network Preview (showing 1 interactants - click image to see more details)

    1 Interacting protein for YBX2 (ENSP000000076994) via UniProtKB, MINT, STRING, and/or I2D
    InteractantInteraction Details
    GeneCardExternal ID(s)
    UBCENSP000003448184STRING: ENSP00000344818
    About this table

    Gene Ontology (GO): 5/10 biological process terms (GO ID links to tree view) (see all 10):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006355regulation of transcription, DNA-dependent IEA--
    GO:0006366transcription from RNA polymerase II promoter TAS10100484
    GO:0007283spermatogenesis TAS10100484
    GO:0007286spermatid development IEA--
    GO:0009386translational attenuation TAS10100484

    YBX2 for ontologies           About GeneDecksing



    Drugs & Compounds
    for YBX2 gene

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section

    YBX2 for compounds           About GeneDecksing

    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for YBX2
    1 Novoseek chemical compound relationship for YBX2 gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    ionol 81.8 12 16624424 (5), 16479255 (4)

    Search CenterWatch for drugs/clinical trials and news about YBX2 / YBOX2 

    Transcripts
    for YBX2 gene

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, Sirion Biotech, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section
    REFSEQ mRNAs for YBX2 gene: 
    NM_015982.3  

    Unigene Cluster for YBX2:

    Y box binding protein 2
    Hs.567494  [show with all ESTs]
    Unigene Representative Sequence: NM_015982
    7 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000007699(uc002gfq.2) ENST00000571834 ENST00000571485 ENST00000571464
    ENST00000570720 ENST00000570627 ENST00000571127

    miRNA
    Products:             		 OriGene 3'-UTR Clone: YBX2
    Browse OriGene MicroRNA Expression Plasmids
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat YBX2
    8/34 QIAGEN miScript miRNA Assays for microRNAs that regulate YBX2 (see all 34):
    hsa-miR-2052 hsa-miR-330-5p hsa-miR-218-1* hsa-miR-765 hsa-miR-650 hsa-miR-764 hsa-miR-1243 hsa-miR-326
    SwitchGear 3'UTR luciferase reporter plasmid: YBX2 3' UTR sequence
    Inhib. RNA
    Products:             		Browse for Gene Knock-down Tools from EMD Millipore
    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for YBX2 (see all 4)
    OriGene shRNA RFP: YBX2
    OriGene siRNA: YBX2
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat YBX2
    Sirion Biotech Custom design and validation of potent shRNA sequences against YBX2 
    Clone
    Products:             		 OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for YBX2 (see all 2)
    OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for YBX2
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling 
    GenScript: all cDNA clones in your preferred vector: YBX2 (NM_015982)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for YBX2
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat YBX2 
    Primer
    Products:            		 OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for YBX2
    Browse OriGene validated miRNA SYBR primer pairs
    SABiosciences RT2 qPCR Primer Assay in human, mouse / rat YBX2
      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat YBX2
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat YBX2

    Additional cDNA sequence: 

    AF096834.1 AK315035.1 BC033800.1 BC047760.1 

    10 DOTS entries:

    DT.424114  DT.75168027  DT.91683704  DT.100738000  DT.120957950  DT.75102929  DT.95151293  DT.409394 
    DT.91975859  DT.95218133 

    24/85 AceView cDNA sequences (see all 85):

    AK092747 CB268201 AI653298 AI805280 BM772139 AI968077 CD359924 AI203057 
    CR617829 BC033800 BC047760 AL041670 AA383400 NM_015982 AF096834 AL041569 
    AI475427 AW294188 BI826956 AI653680 BV198321 BI826968 AW663427 BI826336 

    GeneLoc Exon Structure


    Expression
    for YBX2 gene

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    YBX2 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS
    CGAP TAG: TGCCACCTGA
    YBX2 Expression
    About this image

    YBX2 expression in embryonic tissues and stem cells
    Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine    About this table

    1 LifeMap In Vivo Development Anatomical Compartment/Cell 
    Tissue Anatomical Compartment CellCategory (developmental path)
    OvaryPrimordial FolliclePrimary OocyteFemale Gametocytes, Germ Cells
    Expression: Positive    Negative     Selective marker
    Experimental details: Curated     Microarrays     In-situ hybridization
    Stem Cell Differentiation: 5 LifeMap Cells 
    NameCategory
    Ovarian tissue-dissociated cells (human) (Primary Cell)Ovary, Reproductive System
    Human oogonial stem cells (Oocyte formation by ...)
    Oocytes (Oocyte formation by ...)
    Oocytes (Oocyte formation by ...)
    Human oogonial stem cells (Oocyte formation by ...)

    See YBX2 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for YBX2

    SOURCE GeneReport for Unigene cluster: Hs.567494

    UniProtKB/Swiss-Prot: YBOX2_HUMAN, Q9Y2T7
    Tissue specificity: Expressed in oocytes and testicular germ cells in the stage of spermatogonia to spermatocyte. Also
    observed placental trophoblasts, as well as in vascular smooth muscle cells in the pulmonary artery, myocardium, and
    skeletal muscle. Undetectable in epithelial cells in respiratory, gastrointestinal, and urogenital tracts.
    Up-regulated in various carcinomas and germ cell tumors (at protein level)

        SABiosciences Custom PCR Arrays for YBX2
    Primer
    Products:    		 OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for YBX2
    Browse OriGene validated miRNA SYBR primer pairs
    SABiosciences RT2 qPCR Primer Assay in human, mouse / rat YBX2
    QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat YBX2
    QIAGEN QuantiFast Probe-based Assays in human, mouse, rat YBX2
    In Situ
    Assay Products:     
         		Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for YBX2

    Orthologs
    for YBX2 gene

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section
    This gene was present in the common ancestor of animals.

    Orthologs for YBX2 gene from 3/17 species (see all 17)    About this table
    Organism Taxonomic
    classification    		 Gene Description Human
    Similarity    		 Orthology
    Type    		 Details
    African clawed frog
    (Xenopus laevis)    		 Amphibia FRGY22 sequence -specific binding protein 74.43(n)    M59454.1 
    fruit fly
    (Drosophila melanogaster)    		 Insecta yps6
    		 ypsilon schachtel
    		 26(a)
    		 possible ortholog
    		 3L(12114374-12118250)
    worm
    (Caenorhabditis elegans)    		 Secernentea cey-16
    cey-26
    (see all 4)    		 Y-box family member (cey-2)
    (see all 4)    		 38(a)
    25(a)
    (see all 4)    		 many ↔ many
    many ↔ many
    (see all 4)    		 II(11039391-11041150)
    I(5619570-5620671)


    ENSEMBL Gene Tree for YBX2 (if available)
    TreeFam Gene Tree for YBX2 (if available) 

    Paralogs
    for YBX2 gene

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for YBX2 gene
    CSDA2  YBX12  
    2 SIMAP similar genes for YBX2 using alignment to 3 protein entries:     YBOX2_HUMAN (see all proteins):
    YBX1    CSDA

    YBX2 for paralogs           About GeneDecksing


    2 Pseudogenes.org Pseudogenes for YBX2
    PGOHUM00000238962 PGOHUM00000246931


    Genomic Variants
    for YBX2 gene

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/124 NCBI SNPs in YBX2 are shown (see all 124)     About this table
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance    		Chr 17 posSequence#AA
    Chg    		TypeMore#Allele
    freq    		PopTotal
    sample    		More
    ----------
    rs1433089181,2
    		--7192002(+) AACAGC/TGACTT 1 -- int10--------
    rs1809154541,2
    		--7192025(+) CAGTAC/TCTCAC 1 -- int10--------
    rs2000895791,2
    		--7192084(+) TCTGGG/TTGTCC 1 -- ut310--------
    rs1999476181,2
    		--7192089(+) TGTCC-/TTCTGA 1 -- ut310--------
    rs2228421,2
    		C,F,A,H--7192091(+) GTCCTC/TTGAGT 1 -- ut31 ese326Minor allele frequency- T:0.48EA NS NA CSA WA EU 5321
    rs2016079161,2
    		--7192154(+) GGCTGA/CGGTCT 2 A S mis10--------
    rs2228411,2
    		C,F,A,H--7192198(+) TTTTGT/GTTTTG 1 -- int110Minor allele frequency- G:0.44NA CSA WA EA 374
    rs584739721,2
    		C--7192414(+) GACCCC/TAACTG 1 -- int12Minor allele frequency- T:0.07WA 120
    rs1861407141,2
    		--7192578(+) AAGCTA/GGTAGG 1 -- int10--------
    rs344681521,2
    		C--7192614(+) GGGTTG/-GGGGG 1 -- int11Minor allele frequency- -:0.50CSA 2

    HapMap Linkage Disequilibrium report for YBX2 (7191571 - 7197934 bp)
    Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
          Database of Genomic Variants (DGV) variations for YBX2: --
    Human Gene Mutation Database (HGMD): YBX2

    SABiosciences Cancer Mutation PCR Assays
    QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing YBX2
    DNA2.0 Custom Variant and Variant Library Synthesis for YBX2

    Disorders / Diseases
    for YBX2 gene

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    YBX2 for disorders           About GeneDecksing

    OMIM gene information: 611447    OMIM disorders: --

    7 diseases for YBX2:    About MalaCards
    germ cell tumor    azoospermia    rhinitis    infertility
    tuberculosis    carcinoma    mycobacterium tuberculosis

    1 Novoseek disease relationship for YBX2 gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    shock 34.2 1 9155152 (1)

    Human Genome Epidemiology (HuGE) Navigator: YBX2 (3 documents)

    Export disorders for YBX2 gene to outside databases

    Publications
    for YBX2 gene

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for YBX2 gene, integrated from 9 sources (see all 16):
    (articles sorted by number of sources associating them with YBX2)    		    Utopia: connect your pdf to the dynamic
    world of online information

    1. Contrin, the human homologue of a germ-cell Y-box-binding protein: cloning, expression, and chromosomal localization. (PubMed id 10100484)1, 2, 3, 9 Tekur S.... Hecht N.B. (1999)
    2. Expression of Y-box-binding protein dbpC/contrin, a potentially new cancer/testis antigen. (PubMed id 16479255)1, 2, 9 Kohno Y.... Sasaguri Y. (2006)
    3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    4. Mammalian male and female germ cells express a germ cell-specific Y-Box protein, MSY2. (PubMed id 9780336)1, 3 Gu W....Hecht N.B. (1998)
    5. Sequence alterations in the YBX2 gene are associated with male factor infertility. (PubMed id 18339382)1, 9 Hammoud S....Carrell D.T. (2008)
    6. Expression and cellular localization of dbpC/Contrin in germ cell tumor cell lines. (PubMed id 16624424)1, 9 Yoshida T....Kohno K. (2006)
    7. Some single nucleotide polymorphisms of MSY2 gene might contribute to susceptibility to spermatogenic impairment in idiopathic infertile men. (PubMed id 18372033)1, 9 Deng Y....Zhang S. (2008)
    8. Methods for quantification of in vivo changes in prote in ubiquitination following proteasome and deubiquitinase inhibition. (PubMed id 22505724)1 Udeshi N.D....Carr S.A. (2012)
    9. Systematic and quantitative assessment of the ubiquiti n-modified proteome. (PubMed id 21906983)1 Kim W....Gygi S.P. (2011)
    10. Evaluation of 172 candidate polymorphisms for associa tion with oligozoospermia or azoospermia in a large cohort of men of European d escent. (PubMed id 20378615)1 Aston K.I....Carrell D.T. (2010)

    External Searches for YBX2 gene

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Disorders
    Free Text  
      Query String
    		PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    Genome Databases showing YBX2 gene

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 51087 HGNC: 17948 AceView: YBX2 Ensembl:ENSG00000006047 euGenes: HUgn51087
    ECgene: YBX2 H-InvDB: YBX2

    Other Databases showing YBX2 gene

    (According to HUGE)
    About This Section
    		   --

    Specialized Databases showing YBX2 gene

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for YBX2 Pharmacogenomics, SNPs, Pathways

    Intellectual Property
    for YBX2 gene

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    		Patent Information for YBX2 gene:
    Search GeneIP for patents involving YBX2

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    Products
    for YBX2 gene

    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript, LifeMap BioReagents, and Sirion Biotech, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory)
    About This Section

     
     EMD Millipore Custom Antibody & Bulk Services
     EMD Millipore Preclinical / Clinical Development Services
     EMD Millipore Immunoassay Services
     EMD Millipore Target Screening & Profiling Services

      
     Browse Antibodies   Browse Cell Culture Products  
     Browse ELISAs   Browse Flow Cytometry Kits  
     Browse Primer Pairs   Browse Kinase Activity Assays/Reagents  
     Browse ELISpot Kits/Development Modules   Browse TFB/Immunoprecipitation Assays  
     Browse Apoptosis Detection Kits/Reagents   Browse Ubiquitin Proteasome Pathway (UPP) Assay Kits/Reagents  
     Browse DNA Damage/Repair Kits/Reagents   Browse Multiplex/Array Assay Kits/Reagents  
     Browse Cell Selection/Detection Kits/Reagents   Browse Secondary Antibodies/Controls/Staining Reagents  
     Browse Phosphatase Activity Assays/Reagents   Browse Recombinant/Natural Proteins  
     Browse OriGene Antibodies   OriGene shRNA RFP for YBX2  
     OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for YBX2   OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for YBX2  
     OriGene Protein Over-expression Lysate for YBX2   Browse OriGene Fluorogenic Cell Assay Kits  
     OriGene siRNA for YBX2   OriGene 3'-UTR Clone for YBX2  
     OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for YBX2   OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for YBX2  
     Browse OriGene GFP tagged cDNA clones in CMV expression vector   Browse OriGene MicroRNA Expression Plasmids  
     Browse OriGene basic RS shRNAs   Browse OriGene validated miRNA SYBR primer pairs  
     Browse OriGene full length recombinant human proteins expressed in human HEK293 cells   OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling  
     OriGene Custom Antibody Services for YBX2   OriGene Custom Protein Services for YBX2  
     OriGene Custom Immunoassay Development  

         		 
     QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat YBX2
     QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing YBX2
     QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat YBX2
     QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat YBX2
     QIAGEN QuantiFast Probe-based Assays in human, mouse, rat YBX2
     QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat YBX2
     GenScript Custom Purified and Recombinant Proteins Services for YBX2 GenScript cDNA clones with any tag delivered in your preferred vector for YBX2
     GenScript Custom Assay Services for YBX2 GenScript Custom Superior Antibodies Services for YBX2
     GenScript Custom overexpressing Cell Line Services for YBX2 CloneReady with Over 120,000 Genes
     Gene Synthesis: Any Gene in Any Vector Vector-based siRNA and miRNA, Ready for Transfection
     Gene Mutant Library, Variants up to 10^11 Plasmid Preparation
     Custom Peptide Services
     Search for Antibodies & Assays

     Regulatory tfbs in YBX2 promoter
     Search Chromatin IP Primers for YBX2
     RT2 qPCR Primer Assay in human, mouse / rat YBX2
     Search GNC Networks for YBX2
     SABiosciences Custom PCR Arrays for YBX2
     Search Tocris compounds for YBX2
     Browse Sino Biological Proteins and Antibodies
     Browse Sino Biological cDNA Clones
     Antibodies/Proteins Production Services
     Rabbit Monoclonal Antibody Platform
     Bulk Purchasing
     Search www.enzolifesciences.com for proteins, assays, substrates, inhibitors & antibodies
     Novus Tissue Slides
     YBX2 antibodies
     YBX2 proteins
     YBX2 lysates
     Antibodies for YBX2
     See all of Abcam's Antibodies, Kits and Proteins for YBX2
     Custom Antibody / Protein Production Service
     Bulk Purchasing
     Advantages of Rabbit Monoclonal antibodies
     Abcam protocols and scientific support
     Browse ProSpec Recombinant Proteins




     YBX2 Proteins, Antibodies, CLIAs, and ELISAs
     Search LifeMap BioReagents cell lines for YBX2
     Gene Synthesis
     Protein Engineering
     Variant Library Synthesis
     Codon Optimization
     Protein Production and Purification
     Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for YBX2
     SwitchGear 3'UTR luciferase reporter plasmids for YBX2
     SwitchGear Promoter luciferase reporter plasmids for YBX2
     ThermoFisher Antibodies for YBX2
     Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat YBX2
     inGenious Targeting Laboratory - Customizable classic, inducible, and humanized mouse model solutions for YBX2
    Sirion Biotech Customized:
     stable knockdown cell line services for YBX2
     inducible knockdown cell line services for YBX2
     design and validation of potent shRNA sequences against YBX2
     adenovirus for potent knockdown of YBX2
     adenovirus for overexpression of YBX2
     stable overexpressing cell line services for YBX2
     inducible overexpressing cell line services for YBX2
           
    GeneCards Homepage - Last full update: 19 Mar 2013 - Incrementals: 21 Mar 2013 , 15 Apr 2013 , 26 Apr 2013 , 13 May 2013

    View Random Gene

    Category
    VWF
    (GIFTS: 73)
    von Willebrand factor
    GIFtS Group
    The GeneCards human gene database gene index: 1 3 5 6 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z 

    Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

    Copyright © 1996-2013 , Weizmann Institute of Science. All Rights Reserved.
    Hot genes      Disease genes      YBX2 gene at Home site.
    hostname: 356977-web1.xennexinc.com index build: 106 solr: 1.4