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YBX2 Gene

protein-coding   GIFtS: 54
GCID: GC17M007191

Y Box Binding Protein 2

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(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Y Box Binding Protein 21 2     CONTRIN2
Germ Cell-Specific Y-Box-Binding Protein2 3     DBPC2
CSDA32 3     Germ Cell Specific Y-Box Binding Protein2
MSY22 3     Y-Box-Binding Protein 22
DNA-Binding Protein C2 3     Contrin3
MSY2 Homolog2 3     Dbpc3

External Ids:    HGNC: 179481   Entrez Gene: 510872   Ensembl: ENSG000000060477   OMIM: 6114475   UniProtKB: Q9Y2T73   

Export aliases for YBX2 gene to outside databases

Previous GC identifers: GC17M007549 GC17M007921 GC17M007134 GC17M007392 GC17M007132 GC17M007083


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for YBX2 Gene:
This gene encodes a nucleic acid binding protein which is highly expressed in germ cells. The encoded protein
binds to a Y-box element in the promoters of certain genes but also binds to mRNA transcribed from these genes.
Pseudogenes for this gene are located on chromosome 10 and 15. (provided by RefSeq, Feb 2012)

GeneCards Summary for YBX2 Gene:
YBX2 (Y box binding protein 2) is a protein-coding gene. GO annotations related to this gene include chromatin binding and mRNA 3'-UTR binding. An important paralog of this gene is YBX3.

UniProtKB/Swiss-Prot: YBOX2_HUMAN, Q9Y2T7
Function: Major constituent of messenger ribonucleoprotein particles (mRNPs). Involved in the regulation of the
stability and/or translation of germ cell mRNAs. Binds to Y-box consensus promoter element. Binds to full length
mRNA with high affinity in a sequence-independent manner. Binds to short RNA sequences containing the consensus
site 5'-UCCAUCA-3' with low affinity and limited sequence specificity. Its binding with maternal mRNAs is
necessary for its cytoplasmic retention. May mark specific mRNAs (those transcribed from Y-box promoters) in the
nucleus for cytoplasmic storage, thereby linking transcription and mRNA storage/translational delay (By
similarity)

Gene Wiki entry for YBX2 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000017.10  NC_018928.2  NT_010718.17  
Regulatory elements:
   Regulatory transcription factor binding sites in the YBX2 gene promoter:
         AREB6   C/EBPbeta   PPAR-gamma1   COMP1   Nkx2-5   PPAR-gamma2   LCR-F1   Gfi-1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidYBX2 promoter sequence
   Search Chromatin IP Primers for YBX2

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat YBX2


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 17p13.1   Ensembl cytogenetic band:  17p13.1   HGNC cytogenetic band: 17p13.1

YBX2 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
YBX2 gene location

GeneLoc information about chromosome 17         GeneLoc Exon Structure

GeneLoc location for GC17M007191:  view genomic region     (about GC identifiers)

Start:
7,191,571 bp from pter      End:
7,197,934 bp from pter
Size:
6,364 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., eBioscience, and/or antibodies-online,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., eBioscience, and/or antibodies-online, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, antibodies-online, and/or others.)
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UniProtKB/Swiss-Prot: YBOX2_HUMAN, Q9Y2T7 (See protein sequence)
Recommended Name: Y-box-binding protein 2  
Size: 364 amino acids; 38518 Da
Subunit: Found in a mRNP complex with PABPC1 and YBX3 (By similarity)
Secondary accessions: D3DTP1 Q8N4P0

Explore the universe of human proteins at neXtProt for YBX2: NX_Q9Y2T7

Explore proteomics data for YBX2 at MOPED

Post-translational modifications: 

  • Phosphorylated during oocyte maturation and dephosphorylated following egg activation. Phosphorylated in vitro by
    a kinase activity associated with testicular mRNPs. Dephosphorylation leads to a decrease in its affinity to bind
    RNA in vitro (By similarity)1
  • Ubiquitination2 at Lys99, Lys116
  • Modification sites at PhosphoSitePlus

  • See YBX2 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_057066.2  
    ENSEMBL proteins: 
     ENSP00000007699   ENSP00000459587  

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    antibodies-online proteins for YBX2 (2 products) 

     
    antibodies-online peptides for YBX2

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    antibodies-online antibodies for YBX2 (44 products) 

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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    4 InterPro protein domains:
     IPR019844 Cold-shock_CS
     IPR012340 NA-bd_OB-fold
     IPR011129 Cold_shock_prot
     IPR002059 CSP_DNA-bd

    Graphical View of Domain Structure for InterPro Entry Q9Y2T7

    ProtoNet protein and cluster: Q9Y2T7

    2 Blocks protein domains:
    IPB002059 Cold-shock DNA-binding domain
    IPB011129 Cold shock protein


    UniProtKB/Swiss-Prot: YBOX2_HUMAN, Q9Y2T7
    Similarity: Contains 1 CSD (cold-shock) domain


    Find genes that share domains with YBX2           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: YBOX2_HUMAN, Q9Y2T7
    Function: Major constituent of messenger ribonucleoprotein particles (mRNPs). Involved in the regulation of the
    stability and/or translation of germ cell mRNAs. Binds to Y-box consensus promoter element. Binds to full length
    mRNA with high affinity in a sequence-independent manner. Binds to short RNA sequences containing the consensus
    site 5'-UCCAUCA-3' with low affinity and limited sequence specificity. Its binding with maternal mRNAs is
    necessary for its cytoplasmic retention. May mark specific mRNAs (those transcribed from Y-box promoters) in the
    nucleus for cytoplasmic storage, thereby linking transcription and mRNA storage/translational delay (By
    similarity)

         Gene Ontology (GO): Selected molecular function terms (see all 8):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003676nucleic acid binding ----
    GO:0003677DNA binding IEA--
    GO:0003682chromatin binding IEA--
    GO:0003729mRNA binding ----
    GO:0003730mRNA 3'-UTR binding IEA--
         
    Find genes that share ontologies with YBX2           About GenesLikeMe


    Phenotypes:
         2 GenomeRNAi human phenotypes for YBX2:
     Synthetic lethal with Ras  Synthetic lethal with c-Myc af 

         3 MGI mutant phenotypes (inferred from 1 allele(MGI details for Ybx2):
     cellular  endocrine/exocrine gland  reproductive system 

    Find genes that share phenotypes with YBX2           About GenesLikeMe

    Animal Models:
         MGI mouse knock-out Ybx2tm1Nbh for YBX2

       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for YBX2
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    miRNA
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    hsa-mir-335-5p (MIRT019164)

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    Selected qRT-PCR Assays for microRNAs that regulate YBX2 (see all 34):
    hsa-miR-2052 hsa-miR-330-5p hsa-miR-218-1* hsa-miR-765 hsa-miR-650 hsa-miR-764 hsa-miR-1243 hsa-miR-326
    SwitchGear 3'UTR luciferase reporter plasmidYBX2 3' UTR sequence
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    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    YBOX2_HUMAN, Q9Y2T7: Cytoplasm. Nucleus
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    nucleus5
    cytosol3

    Gene Ontology (GO): 4 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus IEA--
    GO:0005737cytoplasm IEA--
    GO:0005844polysome IEA--
    GO:0030529ribonucleoprotein complex ----

    Find genes that share ontologies with YBX2           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for YBX2
    Interactions:

        Search GeneGlobe Interaction Network for YBX2

    STRING Interaction Network Preview (showing 5 interactants - click image to see 11)

    Selected Interacting proteins for YBX2 (ENSP000000076994) via UniProtKB, MINT, STRING, and/or I2D (see all 11)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    CPEB1ENSP000004141874STRING: ENSP00000414187
    DDX6ENSP000002640184STRING: ENSP00000264018
    PRMT8ENSP000003720674STRING: ENSP00000372067
    CNPENSP000003774704STRING: ENSP00000377470
    GJC2ENSP000003556754STRING: ENSP00000355675
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 10):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006355regulation of transcription, DNA-templated IEA--
    GO:0006366transcription from RNA polymerase II promoter TAS10100484
    GO:0007283spermatogenesis TAS10100484
    GO:0007286spermatid development IEA--
    GO:0009386translational attenuation TAS10100484

    Find genes that share ontologies with YBX2           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for YBX2 (YBOX2)

    1 Novoseek inferred chemical compound relationship for YBX2 gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    ionol 81.8 12 16624424 (5), 16479255 (4)



    Find genes that share compounds with YBX2           About GenesLikeMe



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for YBX2 gene: 
    NM_015982.3  

    Unigene Cluster for YBX2:

    Y box binding protein 2
    Hs.567494  [show with all ESTs]
    Unigene Representative Sequence: NM_015982
    7 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000007699(uc002gfq.2) ENST00000571834 ENST00000571485 ENST00000571464
    ENST00000570720 ENST00000570627 ENST00000571127
    miRNA
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    Block miRNA regulation of human, mouse, rat YBX2 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate YBX2 (see all 34):
    hsa-miR-2052 hsa-miR-330-5p hsa-miR-218-1* hsa-miR-765 hsa-miR-650 hsa-miR-764 hsa-miR-1243 hsa-miR-326
    SwitchGear 3'UTR luciferase reporter plasmidYBX2 3' UTR sequence
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      QuantiTect SYBR Green Assays in human, mouse, rat YBX2
      QuantiFast Probe-based Assays in human, mouse, rat YBX2

    Additional mRNA sequence: 

    AF096834.1 AK315035.1 BC033800.1 BC047760.1 

    10 DOTS entries:

    DT.424114  DT.75168027  DT.91683704  DT.100738000  DT.120957950  DT.75102929  DT.95151293  DT.409394 
    DT.91975859  DT.95218133 

    Selected AceView cDNA sequences (see all 85):

    CB268201 BC033800 AK092747 AA383400 AI805280 AI968077 BC047760 AI203057 
    AI653298 CR617829 CD359924 BM772139 AL041670 AW273185 AI738586 AL041568 
    AA838043 AA883961 BI826968 AF096834 AL041671 CD627356 AL042395 AW294188 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    YBX2 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: TGCCACCTGA
    YBX2 Expression
    About this image


    YBX2 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 5) fully expand
     
     Ovary (Reproductive System)    fully expand to see all 3 entries
             Primary Oocyte Primordial Follicle
             Ovarian tissue-dissociated cells (human)
             Oocytes
     
     Gonad
             Primary Oocyte Primordial Follicle
             Human oogonial stem cells
     
     Germ Cells (Reproductive System)
             Human oogonial stem cells
     
     Testis (Reproductive System)    fully expand to see all 3 entries
             Leydig Cells Testis Interstitium
             Testis Interstitium
     
     Inner Cell Mass (Early Embryonic Tissues)    fully expand to see all 2 entries
             Human embryonic stem cells (family)
    YBX2 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    YBX2 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.567494

    UniProtKB/Swiss-Prot: YBOX2_HUMAN, Q9Y2T7
    Tissue specificity: Expressed in oocytes and testicular germ cells in the stage of spermatogonia to spermatocyte.
    Also observed placental trophoblasts, as well as in vascular smooth muscle cells in the pulmonary artery,
    myocardium, and skeletal muscle. Undetectable in epithelial cells in respiratory, gastrointestinal, and
    urogenital tracts. Up-regulated in various carcinomas and germ cell tumors (at protein level)

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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of animals.

    Orthologs for YBX2 gene from Selected species (see all 11)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Ybx21 , 5 Y box protein 21, 5 89.62(n)1
    91.72(a)1
      11 (42.93 cM)5
    534221  NM_016875.21  NP_058571.21 
     699357965 
    African clawed frog
    (Xenopus laevis)
    Amphibia FRGY22 sequence -specific binding protein 74.43(n)    M59454.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta yps6
    ypsilon schachtel
    30(a)
    1 → many
    3L(12114374-12118250)
    worm
    (Caenorhabditis elegans)
    Secernentea cey-16
    cey-46
    (see all 4)
    Protein CEY-4 (cey-4) mRNA, complete cds
    (see all 4)
    37(a)
    25(a)
    (see all 4)
    many ↔ many
    many ↔ many
    (see all 4)
    II(11039449-11041206) WBGene00000472
    III(10866946-10868727) WBGene00000475


    ENSEMBL Gene Tree for YBX2 (if available)
    TreeFam Gene Tree for YBX2 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for YBX2 gene
    YBX32  YBX12  
    3 SIMAP similar genes for YBX2 using alignment to 3 protein entries:     YBOX2_HUMAN (see all proteins):
    RGMA    YBX1    YBX3

    Find genes that share paralogs with YBX2           About GenesLikeMe


    2 Pseudogenes.org Pseudogenes for YBX2
    PGOHUM00000238962 PGOHUM00000246931


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for YBX2 (see all 177)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 17 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1433089181,2
    --7192002(+) AACAGC/TGACTT 1 -- int10--------
    rs1809154541,2
    --7192025(+) CAGTAC/TCTCAC 1 -- int10--------
    rs2000895791,2
    --7192084(+) TCTGGG/TTGTCC 1 -- ut310--------
    rs1999476181,2
    --7192089(+) TGTCC-/TTCTGA 1 -- ut310--------
    rs2228421,2
    C,F,A,H--7192091(+) GTCCTC/TTGAGT 1 -- ut31 ese326Minor allele frequency- T:0.48EA NS NA CSA WA EU 5321
    rs2016079161,2
    --7192154(+) GGCTGA/CGGTCT 2 A S mis10--------
    rs2228411,2
    C,F,A,H--7192198(+) TTTTGT/GTTTTG 1 -- int110Minor allele frequency- G:0.44NA CSA WA EA 374
    rs584739721,2
    C,F--7192414(+) GACCCC/TAACTG 1 -- int12Minor allele frequency- T:0.07WA 120
    rs1861407141,2
    --7192578(+) AAGCTA/GGTAGG 1 -- int10--------
    rs344681521,2
    C--7192614(+) GGGTTG/-GGGGG 1 -- int11Minor allele frequency- -:0.50CSA 2

    HapMap Linkage Disequilibrium report for YBX2 (7191571 - 7197934 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 7 variations for YBX2:    About this table    
    Variant IDTypeSubtypePubMed ID
    esv2665200CNV Deletion23128226
    esv2422288CNV Deletion17116639
    nsv907641CNV Loss21882294
    nsv907637CNV Loss21882294
    dgv3053n71CNV Loss21882294
    nsv457659CNV Loss19166990
    nsv1963CNV Loss18451855

    Human Gene Mutation Database (HGMD): YBX2
    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing YBX2
    DNA2.0 Custom Variant and Variant Library Synthesis for YBX2

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 611447    OMIM disorders: --

    1 disease from the University of Copenhagen DISEASES database for YBX2:
    Rhinitis

    Find genes that share disorders with YBX2           About GenesLikeMe

    1 Novoseek inferred disease relationship for YBX2 gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    shock 34.2 1 9155152 (1)

    Genetic Association Database (GAD): YBX2
    Human Genome Epidemiology (HuGE) Navigator: YBX2 (3 documents)

    Export disorders for YBX2 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for YBX2 gene, integrated from 10 sources (see all 22):
    (articles sorted by number of sources associating them with YBX2)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Contrin, the human homologue of a germ-cell Y-box-binding protein: cloning, expression, and chromosomal localization. (PubMed id 10100484)1, 2, 3, 9 Tekur S.... Hecht N.B. (J. Androl. 1999)
    2. Sequence alterations in the YBX2 gene are associated with male factor infertility. (PubMed id 18339382)1, 4, 9 Hammoud S....Carrell D.T. (Fertil. Steril. 2009)
    3. Expression of Y-box-binding protein dbpC/contrin, a potentially new cancer/testis antigen. (PubMed id 16479255)1, 2, 9 Kohno Y.... Sasaguri Y. (Br. J. Cancer 2006)
    4. Some single nucleotide polymorphisms of MSY2 gene might contribute to susceptibility to spermatogenic impairment in idiopathic infertile men. (PubMed id 18372033)1, 4, 9 Deng Y....Zhang S. (Urology 2008)
    5. Evaluation of 172 candidate polymorphisms for association with oligozoospermia or azoospermia in a large cohort of men of European descent. (PubMed id 20378615)1, 4 Aston K.I....Carrell D.T. (Hum. Reprod. 2010)
    6. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    7. Mammalian male and female germ cells express a germ cell-specific Y-Box protein, MSY2. (PubMed id 9780336)1, 3 Gu W....Hecht N.B. (Biol. Reprod. 1998)
    8. Expression and cellular localization of dbpC/Contrin in germ cell tumor cell lines. (PubMed id 16624424)1, 9 Yoshida T....Kohno K. (Biochim. Biophys. Acta 2006)
    9. The intracellular interactome of tetraspanin-enriched microdomains reveals their function as sorting machineries toward exosomes. (PubMed id 23463506)1 Perez-Hernandez D....YA!A+ez-MA^ M. (J. Biol. Chem. 2013)
    10. The functional interactome landscape of the human histone deacetylase family. (PubMed id 23752268)1 Joshi P....Cristea I.M. (Mol. Syst. Biol. 2013)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section

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    Entrez Gene: 51087 HGNC: 17948 AceView: YBX2 Ensembl:ENSG00000006047 euGenes: HUgn51087
    ECgene: YBX2 H-InvDB: YBX2

    (According to HUGE)
    About This Section

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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
    About This Section

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    NameDescription
    PharmGKB entry for YBX2 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section

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    Patent Information for YBX2 gene:
    Search GeneIP for patents involving YBX2

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, eBioscience, antibodies-online, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
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