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Aliases & Descriptions for YBX2
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc
, and/or 7Ensembl,
8miRBase) About This Section
|
| Aliases |
|---|
| CONTRIN 2 | | CSDA3 1, 2, 3 | | Contrin 3 | | DBPC 2 | | Dbpc 3 | | MGC45104 2 | | MSY2 1, 2, 3 |
| | | Descriptions |
|---|
| DNA-binding protein C 3 | | Germ cell-specific Y-box-binding protein 3 | | MSY2 homolog 3 | | Y box binding protein 2 2 | | germ cell specific Y-box binding protein 2 |
|
| | Search outside databases for aliases for YBX2 genePrevious GC identifers: GC17M007549 GC17M007921 GC17M007134 GC17M007392 |
Summaries for YBX2(According to Entrez Gene,
Wikipedia's
Gene Wiki,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
| EntrezGene summary for YBX2: YBX2 is a germ-cell specific member of the vertebrate Y box family of nucleic acid-binding proteins (Gu et al., 1998 [PubMed 9780336]; Tekur et al., 1999 [PubMed 10100484]).[supplied by OMIM] UniProtKB/Swiss-Prot: YBOX2_HUMAN, Q9Y2T7Function: Major constituent of messenger ribonucleoprotein particles (mRNPs). Involved in the regulation of the stability and/or translation of germ cell mRNAs. Binds to Y-box consensus promoter element. Binds to full length mRNA with high affinity in a sequence-independent manner. Binds to short RNA sequences containing the consensus site 5'-UCCAUCA-3' with low affinity and limited sequence specificity. Its binding with maternal mRNAs is necessary for its cytoplasmic retention. May mark specific mRNAs (those transcribed from Y-box promoters) in the nucleus for cytoplasmic storage, thereby linking transcription and mRNA storage/translational delay (By similarity)Gene Wiki entry for YBX2 |
Genomic Location for YBX2
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 36),
and/or miRBase,
Genomic Views according to
UCSC and
Ensembl,
Transcription factor binding sites according to
SABiosciences) About This Section
| Genomic View: UCSC Golden Path with GeneCards custom track
Transcription factor binding sites upstream to the YBX2 gene 
Entrez Gene cytogenetic band: 17p11.2-p13.1 Ensembl cytogenetic band: 17p13.1 HGNC cytogenetic band: 17p13.1YBX2 Gene in genomic location: bands according to Ensembl, locations according to
(and/or Entrez Gene and/or Ensembl if different)
 GeneLoc gene densities for chromosome 17 GeneLoc Exon Structure GeneLoc location for GC17M007132:
(about GC identifiers)
Start:
|
7,132,295 bp from pter |
End:
|
7,138,600 bp from pter |
Size:
|
6,306 bases |
Orientation:
|
minus strand |
RefSeq DNA sequence:- NC_000017.9 NT_010718.15
| Proteins for YBX2
(According to
1UniProtKB,
and/or Ensembl,
Phosphorylation sites according to 2Phosphosite,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from Invitrogen,
Millipore,
Sigma-Aldrich,
R&D Systems,
Enzo Life Sciences,
Abnova,
OriGene and/or,
Abcam,
Biochemical Assays by
Invitrogen,
Millipore,
R&D Systems,
Cell Signaling Technology, and/or
Enzo Life Sciences,
Ontologies according to Gene
Ontology Consortium 01 Apr 2009 and
Entrez Gene,
Antibodies by Invitrogen,
Millipore,
Sigma-Aldrich,
R&D Systems,
Cell Signaling Technology,
Abcam,
Abnova, and/or
Novus Biologicals)
About This Section
| UniProtKB/Swiss-Prot: YBOX2_HUMAN, Q9Y2T7 (See
protein sequence)Recommended Name: Y-box-binding protein 2 Size: 364 amino acids; 38518 Da
Subunit: Found in a mRNP complex with PABPC1 and CSDA (By similarity)
Subcellular location: Cytoplasm. Nucleus
Secondary accessions: Q8N4P0Post-translational modifications:
Phosphorylated during oocyte maturation and dephosphorylated following egg activation. Phosphorylated in vitro by a kinase activity associated with testicular mRNPs. Dephosphorylation leads to a decrease in its affinity to bind RNA in vitro (By similarity)1
REFSEQ proteins: NP_057066.2
ENSEMBL proteins: ENSP00000007699
Human Recombinant Proteins Browse Origene for full length recombinant human proteins expressed in human HEK293 cells 
2 Gene Ontology (GO) cellular component terms (links to tree view): About this table
Antibodies for YBX2: Assays for YBX2: | Protein
Domains/ Families for YBX2(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
| - Graphical View of Domain Structure for InterPro Entry Q9Y2T7
ProtoNet protein and cluster: Q9Y2T7 2 Blocks protein families: IPB002059 Cold-shock DNA-binding domain IPB011129 Cold shock protein
UniProtKB/Swiss-Prot: YBOX2_HUMAN, Q9Y2T7Similarity: Contains 1 CSD (cold-shock) domain | Gene Function for YBX2
(According to MGI Jun 06 2009, UniProtKB,
IUBMB,and/or Genatlas,
shRNA from
OriGene,
Sigma-Aldrich, RNAi from
Sigma-Aldrich,
RNAi Products,
Clones, and
Q-PCR Products
from Invitrogen,
Millipore,
OriGene, and/or
Abnova,
siRNAs from
Applied Biosystems,
SYBR primers from OriGene,
Cell-based Assays from Millipore,
Ontologies according to Gene Ontology Consortium 01 Apr 2009 via
Entrez Gene.)
About This Section
|               OriGene 29mer shRNA kit in GFP-retroviral vector: NM_015982
Applied Biosystems Silencer® siRNAs for YBX2
Sigma-Aldrich siRNA for YBX2  Sigma-Aldrich shRNA for YBX2  Explore Sigma-Aldrich super-pooled esiRNAs 
              OriGene GFP tagged cDNA clone in CMV expression vector: NM_015982                                  Myc/DDK tagged cDNA clone in CMV expression vector: NM_015982                                  untagged cDNA clones in CMV expression vector (see all 2): NM_015982 
Primers: Browse
Quantitative PCR Central at Invitrogen for Q-PCR LUX™ Primers               OriGene genome-wide validated SYBR primer pairs: NM_015982
UniProtKB/Swiss-Prot: YBOX2_HUMAN, Q9Y2T7Function: Major constituent of messenger ribonucleoprotein particles (mRNPs). Involved in the regulation of the stability and/or translation of germ cell mRNAs. Binds to Y-box consensus promoter element. Binds to full length mRNA with high affinity in a sequence-independent manner. Binds to short RNA sequences containing the consensus site 5'-UCCAUCA-3' with low affinity and limited sequence specificity. Its binding with maternal mRNAs is necessary for its cytoplasmic retention. May mark specific mRNAs (those transcribed from Y-box promoters) in the nucleus for cytoplasmic storage, thereby linking transcription and mRNA storage/translational delay (By similarity)2 MGI mutant phenotypes (inferred from 1 allele ) (MGI details for Ybx2):
2 Gene Ontology (GO) molecular function terms (links to tree view): About this table | Pathways & Interactions for YBX2
(Pathways according to Invitrogen
(maps by GeneGo),
Millipore,
Cell Signaling Technology,
Sigma-Aldrich,
KEGG
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Proteins Network according to
SABiosciences,
Interactions according to 1UniProtKB,
2MINT, and/or
3STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Apr 2009 via
Entrez Gene.)
About This Section
|
4 Interacting proteins for YBX2 (ENSP000000076993) via UniProtKB, MINT, and/or STRINGAbout this table
4 Gene Ontology (GO) biological process terms (links to tree view): About this table
|
Drugs & Compounds for YBX2(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
Sigma-Aldrich, Tocris Bioscience, and/or
Novoseek and Drugs according to
Enzo Life Sciences and/or
PharmGKB)
About This Section
|
Browse Tocris compounds for YBX2
|
Transcripts for YBX2(GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 219 Homo sapiens; Jun 2 2009) or GenBank, RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
non coding RNAs according to
RNAdb,
ESTs according to GeneTide,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from Invitrogen,
Millipore, and/or
Abnova,
siRNAs from Applied Biosystems,
Sigma-Aldrich,
shRNA from
Sigma-Aldrich,
OriGene,
Tagged/untagged cDNA clones from
OriGene, Expression Assays from Applied Biosystems) About This Section
|               OriGene 29mer shRNA kit in GFP-retroviral vector: NM_015982
Sigma-Aldrich siRNA for YBX2  Sigma-Aldrich shRNA for YBX2  Explore Sigma-Aldrich super-pooled esiRNAs 
Applied Biosystems Silencer® siRNAs: NM_015982 REFSEQ mRNAs for YBX2 gene: NM_015982.3
Applied Biosystems TaqMan ® Gene Expression Assays: NM_015982               OriGene GFP tagged cDNA clone in CMV expression vector: NM_015982                                  Myc/DDK tagged cDNA clone in CMV expression vector: NM_015982                                  untagged cDNA clones in CMV expression vector (see all 2): NM_015982  Additional cDNA sequence: AF096834.1 AK092747.1 AK315035.1 BC033800.1 BC047760.1 CR617829.1 10 DOTS entries: DT.424114 DT.75168027 DT.91683704 DT.100738000 DT.120957950 DT.75102929 DT.95151293 DT.409394 DT.91975859 DT.95218133 24/85 AceView cDNA sequences (see all 85
):AL041670 BC047760 AI653298 CD359924 BC033800 BM772139 AA383400 AI805280 AK092747 CB268201 AI203057 AI968077 CR617829 BM553247 AL041569 AA883961 AL042395 AA579771 BM854748 BM563498 AI738586 AA504349 NM_015982 AW273185
highest scoring ESTs for YBX2:AF096834 AL042395 BC033800 BC047760 BI825507 BI825872 BI826336 BI828225 BI828701 BI829851 Unigene Cluster for YBX2: Y box binding protein 2 Hs.567494 [show with all ESTs]Unigene Representative Sequence: AK092747
GeneLoc Exon Structure
1 Ensembl transcript including schematic representation: ENST00000007699
|
Expression for YBX2
(Experimental results according to
1GeneNote
and GNF BioGPS,
probe sets-to-genes annotations according to
2GeneAnnot ,
3GeneTide ,
Sets of similar genes according to GeneDecks,
Electronic Northern calculations according to data from
UniGene (Build 219 Homo sapiens),
SAGE tags according to
CGAP,
plus additional links to
SOURCE, and/or
GNF
BioGPS, and/or
EXPOLDB, and/or
UniProtKB,
Expression Assays from
Applied Biosystems
)
About This Section
| YBX2 expression in normal and diseased human tissues
Applied Biosystems TaqMan ® Gene Expression Assays for YBX2
1 / 2 / 3 4 probe-sets matching YBX2 gene Data from
(Publications) and GNF BioGPS About these images About these images
CGAP SAGE TAG: TGCCACCTGA
SOURCE GeneReport for Unigene cluster: Hs.567494 UniProtKB/Swiss-Prot: YBOX2_HUMAN, Q9Y2T7Tissue specificity: Expressed in oocytes and testicular germ cells in the stage of spermatogonia to spermatocyte. Also observed placental trophoblasts, as well as in vascular smooth muscle cells in the pulmonary artery, myocardium, and skeletal muscle. Undetectable in epithelial cells in respiratory, gastrointestinal, and urogenital tracts. Up-regulated in various carcinomas and germ cell tumors (at protein level) |
Orthologs for YBX2
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
and/or
5MGI Jun 06 2009,
with possible further links to
Flybase
and/or
WormBase,
Gene Trees according to Ensembl)
About This Section
|
Orthologs for YBX2 gene from 5/7 species (see all 7
)
About this table Species with no ortholog for YBX2
ENSEMBL Gene Tree for YBX2 | Paralogs for YBX2(Paralogs according to 1HomoloGene and 2Ensembl, Pseudogenes according to 3Pseudogene.org) About This Section
| Paralogs for YBX2 gene
- CSDA2 YBX12
Pseudogenes
- 1 related pseudogene
|
SNPs/Variants for YBX2(According to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE, and
UniProtKB,
Linkage Disequilibrium by HapMap,
Genotyping Reagents from
Applied Biosystems)
About This Section
|
HapMap Linkage Disequilibrium images for YBX2 (up to first 250kb)
|
Disorders & Mutations for YBX2
(in which this Gene is Involved, According to
OMIM, UniProtKB,
Novoseek, PharmGKB,
Genatlas, GeneTests,
Blood group antigen gene mutations by BGMUT,
HGMD, GAD,
HuGE Navigator,
BCGD,
and/or TGDB.)
About This Section
|
OMIM: 611447
1 Novoseek disease relationship for YBX2 gene
| Disease |
Score |
Articles |
PubMed IDs for Articles with Shared Sentences (# sentences) |
| shock |
35.09 |
1 |
9155152 (1) |
About this table
Human Gene Mutation Database: YBX2 Human Genome Epidemiology Navigator: YBX2 (2 documents)
|
Medical News for YBX2(Possibly Related Articles in
Doctor's Guide)
About This Section
| -- |
Publications for YBX2 (in
PubMed.
Associations of this gene to articles via
1Novoseek,
2HGNC,
3Entrez Gene,
4UniProtKB/Swiss-Prot,
5UniProtKB/TrEMBL,
6GAD, and/or
7PharmGKB)
About This Section
| 10/12 PubMed articles for YBX2 gene (see all 12
):- Contrin, the human homologue of a germ-cell Y-box-binding protein: cloning, expression, and chromosomal localization. (PubMed id 10100484)1, 2, 3, 4 Tekur S.... Hecht N.B. (1999)
- Expression of Y-box-binding protein dbpC/contrin, a potentially new cancer/testis antigen. (PubMed id 16479255)1, 3, 4 Kohno Y.... Sasaguri Y. (2006)
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)3, 4 Gerhard D.S....Malek J. (2004)
- Mammalian male and female germ cells express a germ cell-specific Y-Box protein, MSY2. (PubMed id 9780336)2, 3 Gu W....Hecht N.B. (1998)
- Sequence alterations in the YBX2 gene are associated with male factor infertility. (PubMed id 18339382)1, 3 Hammoud S....Carrell D.T. (2008)
- Expression and cellular localization of dbpC/Contrin in germ cell tumor cell lines. (PubMed id 16624424)1, 3 Yoshida T....Kohno K. (2006)
- Some single nucleotide polymorphisms of MSY2 gene might contribute to susceptibility to spermatogenic impairment in idiopathic infertile men. (PubMed id 18372033)1, 3 Deng Y....Zhang S. (2008)
- Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. (PubMed id 16344560)3 Kimura K.... Sugano S. (2006)
- Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)3 Ota T....Sugano S. (2004)
- Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)3 Strausberg R.L....Marra M.A. (2002)
|
Search for YBX2
(in PubMed,
OMIM, and NCBI Bookshelf) About This Section
|
|
Genome Databases showing YBX2
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
and/or
H-InvDB)
About This Section
|
| Other Databases showing YBX2
(According to HUGE)
About This Section
| -- |
Specialized Databases showing YBX2(According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL, Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot) About This Section
|
| About This Section
| --
| Services for YBX2(Reagents available from Applied Biosystems, Antibodies and assays by Cell
Signaling Technology, Abcam, Novus Biologicals, Sigma-Aldrich, R&D Systems, Millipore, Abnova, and/or Invitrogen, Clones available from OriGene,and/or Invitrogen, Drugs and/or compounds by Sigma-Aldrich, Enzo Life Sciences, and/or Tocris Bioscience) About This Section
| 
 Products for YBX2:

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