Aliases for YBX1 Gene
External Ids for YBX1 Gene
Previous HGNC Symbols for YBX1 Gene
Previous GeneCards Identifiers for YBX1 Gene
GeneCards Summary for YBX1 Gene
YBX1 (Y Box Binding Protein 1) is a Protein Coding gene. Among its related pathways are Signaling events mediated by PTP1B and Translational Control. GO annotations related to this gene include sequence-specific DNA binding transcription factor activity and double-stranded DNA binding. An important paralog of this gene is YBX2.
UniProtKB/Swiss-Prot for YBX1 Gene
Mediates pre-mRNA alternative splicing regulation. Binds to splice sites in pre-mRNA and regulates splice site selection. Binds and stabilizes cytoplasmic mRNA. Contributes to the regulation of translation by modulating the interaction between the mRNA and eukaryotic initiation factors (By similarity). Regulates the transcription of numerous genes. Its transcriptional activity on the multidrug resistance gene MDR1 is enhanced in presence of the APEX1 acetylated form at Lys-6 and Lys-7. Binds to promoters that contain a Y-box (5-CTGATTGGCCAA-3), such as MDR1 and HLA class II genes. Promotes separation of DNA strands that contain mismatches or are modified by cisplatin. Has endonucleolytic activity and can introduce nicks or breaks into double-stranded DNA (in vitro). May play a role in DNA repair. Component of the CRD-mediated complex that promotes MYC mRNA stability. Binds preferentially to the 5-[CU]CUGCG-3 motif in vitro.
The secreted form acts as an extracellular mitogen and stimulates cell migration and proliferation