YBX1 Gene
protein-coding GIFtS: 55
GCID: GC01P043148
|
|
Y box binding protein 1(Previous name: nuclease sensitive element binding protein 1 )
(Previous symbol: NSEP1)
| |
Aliases
for YBX1 gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| Y Box Binding Protein 11 2 | | Nuclease Sensitive Element Binding Protein 11 2 | | DBPB1 2 3 5 | | Enhancer Factor I Subunit A2 3 | | NSEP11 2 3 5 | | CBF-A2 3 | | YB11 2 3 5 | | EFI-A2 3 | | YB-11 2 3 | | CCAAT-Binding Transcription Factor I Subunit A2 3 | | BP-81 2 | | DNA-Binding Protein B2 3 | | CSDA21 2 | | Y-Box Transcription Factor2 3 | | CSDB1 2 | | Y-Box-Binding Protein 12 3 | | MDR-NF11 2 | | Major Histocompatibility Complex, Class II, Y Box-Binding Protein I2 | | NSEP-11 2 | | Nuclease-Sensitive Element-Binding Protein 12 |
Export aliases for YBX1 gene to outside databasesPrevious GC identifers: GC01P042818 GC01P042920 GC01P041268 |
Summaries
for YBX1 gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
UniProtKB/Swiss-Prot: YBOX1_HUMAN, P67809Function: Mediates pre-mRNA alternative splicing regulation. Binds to splice sites in pre-mRNA and regulates splicesite selection. Binds and stabilizes cytoplasmic mRNA. Contributes to the regulation of translation by modulating theinteraction between the mRNA and eukaryotic initiation factors (By similarity). Regulates the transcription ofnumerous genes. Its transcriptional activity on the multidrug resistance gene MDR1 is enhanced in presence of theAPEX1 acetylated form at 'Lys-6' and 'Lys-7'. Binds to promoters that contain a Y-box (5'-CTGATTGGCCAA-3'), such asMDR1 and HLA class II genes. Promotes separation of DNA strands that contain mismatches or are modified by cisplatin.Has endonucleolytic activity and can introduce nicks or breaks into double-stranded DNA (in vitro). May play a role inDNA repair. Component of the CRD-mediated complex that promotes MYC mRNA stability. Binds preferentially to the5'-[CU]CUGCG-3' motif in vitroFunction: The secreted form acts as an extracellular mitogen and stimulates cell migration and proliferation
Gene Wiki entry for YBX1 (Y box binding protein 1)
|
Genomic Views
for YBX1 gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000001.10 NC_018912.1 NT_032977.9
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the YBX1 gene promoter:
Max1 NF-1 AP-1 ATF-2 LCR-F1 YY1 FAC1 c-Jun NF-Y CBF(2)
Other transcription factors
Search SABiosciences Chromatin IP Primers for YBX1
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat YBX1 |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 1p34 Ensembl cytogenetic band: 1p34.2 HGNC cytogenetic band: 1p34YBX1 Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 1 GeneLoc Exon Structure GeneLoc location for GC01P043148: view genomic region
(about GC identifiers)
Start:
|
43,148,066 bp from pter |
End:
|
43,168,020 bp from pter |
Size:
|
19,955 bases |
Orientation:
|
plus strand |
|
Proteins
for YBX1 gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: YBOX1_HUMAN, P67809 (See
protein sequence)Recommended Name: Nuclease-sensitive element-binding protein 1 Size: 324 amino acids; 35924 Da
Subunit: Identified in a histone pre-mRNA complex, at least composed of ERI1, LSM11, SLBP, SNRPB, SYNCRIP and YBX1 (Bysimilarity). Component of the coding region determinant (CRD)-mediated complex, composed of DHX9, HNRNPU, IGF2BP1,SYNCRIP and YBX1. Identified in a mRNP complex, at least composed of DHX9, DDX3X, ELAVL1, HNRNPU, IGF2BP1, ILF3,PABPC1, PCBP2, PTBP2, STAU1, STAU2, SYNCRIP and YBX1. Identified in a mRNP granule complex, at least composed of ACTB,ACTN4, DHX9, ERG, HNRNPA1, HNRNPA2B1, HNRNPAB, HNRNPD, HNRNPL, HNRNPR, HNRNPU, HSPA1, HSPA8, IGF2BP1, ILF2, ILF3,NCBP1, NCL, PABPC1, PABPC4, PABPN1, RPLP0, RPS3, RPS3A, RPS4X, RPS8, RPS9, SYNCRIP, TROVE2, YBX1 and untranslatedmRNAs. Component of the U11/U12 snRNPs that are part of the U12-type spliceosome. Interacts with IGF2BP1 and RBBP6.Component of cytoplasmic messenger ribonucleoprotein particles (mRNPs). Interacts with AKT1, MBNL1, SFRS9,ALYREF/THOC4, MSH2, XRCC5, WRN and NCL. Can bind to DNA as a homomeric form, (EFI-A)n or as a heteromeric form inassociation with EFI-B. Homodimer in the presence of ATP. Interacts (via C-terminus) with APEX1 (via N-terminus); theinteraction is increased with APEX1 acetylated at 'Lys-6' and 'Lys-7'. Interacts with EIF2C1 and EIF2C2
Subcellular location: Cytoplasm. Nucleus. Cytoplasmic granule. Secreted. Note=Localized in cytoplasmic mRNP granulescontaining untranslated mRNAs. Shuttles between nucleus and cytoplasm. Predominantly cytoplasmic in proliferatingcells. Cytotoxic stress and DNA damage enhance translocation to the nucleus. Localized with DDX1, MBNL1 and TIAL1 instress granules upon stress. Secreted by mesangial and monocytic cells after inflammatory challenges. Translocatesfrom the cytoplasm to the nucleus after and colocalizes with APEX1 in nuclear speckles after genotoxic stress
Sequence caution: Sequence=AAA35750.1; Type=Erroneous initiation; Note=Translation N-terminally shortened;Sequence=AAA59949.1; Type=Frameshift; Positions=Several; Sequence=AAA61308.1; Type=Frameshift; Positions=314;
1 PDB 3D structure from  and Proteopedia  for YBX1:1H95 (3D)
Secondary accessions: P16990 P16991 Q14972 Q15325 Q5FVF0Explore the universe of human proteins at neXtProt for YBX1: NX_P67809
Post-translational modifications:
Ubiquitinated by RBBP6; leading to a decrease of YBX1 transcactivational ability1
In the absence of phosphorylation the protein is retained in the cytoplasm1
Cleaved by a 20S proteasomal protease in response to agents that damage DNA. Cleavage takes place in the absence ofubiquitination and ATP. The resulting N-terminal fragment accumulates in the nucleus (By similarity)1
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_P67809
YBX1 Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins: NP_004550.2
ENSEMBL proteins: ENSP00000361626 ENSP00000405937 ENSP00000389639 Reactome Protein details: P67809
Human Recombinant Protein Products:
Gene Ontology (GO): 5/10 cellular component terms (GO ID links to tree view) (see all 10): About this table
YBX1 for ontologies About GeneDecksing
YBX1 Antibody Products:
Assay Products for YBX1: |
Protein
Domains /
Families
for YBX1 gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
YBX1 for domains About GeneDecksing
4 InterPro domains/families:Graphical View of Domain Structure for InterPro Entry P67809ProtoNet protein and cluster: P67809 2 Blocks protein families: IPB002059 Cold-shock DNA-binding domain IPB011129 Cold shock protein
UniProtKB/Swiss-Prot: YBOX1_HUMAN, P67809Similarity: Contains 1 CSD (cold-shock) domain |
Function
for YBX1 gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Function Summary:
UniProtKB/Swiss-Prot: YBOX1_HUMAN, P67809Function: Mediates pre-mRNA alternative splicing regulation. Binds to splice sites in pre-mRNA and regulates splicesite selection. Binds and stabilizes cytoplasmic mRNA. Contributes to the regulation of translation by modulating theinteraction between the mRNA and eukaryotic initiation factors (By similarity). Regulates the transcription ofnumerous genes. Its transcriptional activity on the multidrug resistance gene MDR1 is enhanced in presence of theAPEX1 acetylated form at 'Lys-6' and 'Lys-7'. Binds to promoters that contain a Y-box (5'-CTGATTGGCCAA-3'), such asMDR1 and HLA class II genes. Promotes separation of DNA strands that contain mismatches or are modified by cisplatin.Has endonucleolytic activity and can introduce nicks or breaks into double-stranded DNA (in vitro). May play a role inDNA repair. Component of the CRD-mediated complex that promotes MYC mRNA stability. Binds preferentially to the5'-[CU]CUGCG-3' motif in vitroFunction: The secreted form acts as an extracellular mitogen and stimulates cell migration and proliferation
Clone
Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for YBX1 (see all 5)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for YBX1
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling 
| |  | GenScript: all cDNA clones in your preferred vector: YBX1 (NM_004559) | |  | Browse Sino Biological Human cDNA Clones | |  | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for YBX1 | |  | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat YBX1 |
In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for YBX1 |
Gene Ontology (GO): 5/6 molecular function terms (GO ID links to tree view) (see all 6): About this table
YBX1 for ontologies About GeneDecksing
Animal Models:
Mouse knock-outs for YBX1: Ybx1tm1Ley Ybx1tm1Tuch
13 MGI mutant phenotypes (inferred from 3 alleles ) (MGI details for Ybx1):
YBX1 for phenotypes About GeneDecksing
|
Pathways & Interactions
for YBX1 gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Unified GeneCards pathways - 5/7 super-pathways (see all 7) About this table
See pathways by source
| Super-pathway | contained gene-specific pathways |
|---|
| 1 | mRNA Splicing - Major Pathway | | | 2 | PI3K / Akt Signaling | | | 3 | SIDS Susceptibility Pathways | | | 4 | IL-2 Signaling Pathway | | | 5 | Signaling events mediated by PTP1B | |
Pathway sources
See GeneCards unified pathways
Show all pathways
2 
Cell Signaling Technology (CST) Pathways for YBX1
4  BioSystems Pathways for YBX1
5 
Reactome Pathways for YBX1
YBX1 for pathways About GeneDecksing
Interactions:
SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for YBX1
STRING Interaction
Network Preview (showing 5 interactants - click image to see 25)
5/371 Interacting proteins for YBX1 (P678091, 2, 3 ENSP000003616264) via UniProtKB, MINT, STRING, and/or I2D (see all 371)| Interactant | Interaction Details |
|---|
| GeneCard | External ID(s) |
|---|
| FBXO33 | Q7Z6M22, 3, ENSP000002980974 | MINT-2831655 MINT-2831487 MINT-2831514 MINT-2831737 MINT-2831765 I2D:
score=2 STRING: ENSP00000298097 | | PITX2 | Q996972, 3, ENSP000003041694 | MINT-6823857 MINT-6823877 MINT-6823902 I2D:
score=1 STRING: ENSP00000304169 | | GSK3B | P498412, 3, ENSP000003248064 | MINT-65983 MINT-65986 I2D:
score=3 STRING: ENSP00000324806 | | HNRNPK | P619782, 3, ENSP000003654394 | MINT-6823857 MINT-6823877 I2D:
score=3 STRING: ENSP00000365439 | | MAPK1 | P284822, 3, ENSP000002158324 | MINT-65982 MINT-65987 I2D:
score=3 STRING: ENSP00000215832 |
About this table
Gene Ontology (GO): 5/11 biological process terms (GO ID links to tree view) (see all 11): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0000122 | negative regulation of transcription from RNA polymerase II promoter |
IEA | -- | | GO:0000398 | mRNA splicing, via spliceosome |
TAS | -- | | GO:0001701 | in utero embryonic development |
IEA | -- | | GO:0006355 | regulation of transcription, DNA-dependent |
NAS | -- | | GO:0006366 | transcription from RNA polymerase II promoter |
TAS | 3174636 |
YBX1 for ontologies About GeneDecksing
|
Drugs & Compounds
for YBX1 gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
YBX1 for compounds About GeneDecksing
 Browse Tocris compounds for YBX1
10/21 Novoseek chemical compound relationships for YBX1 gene (see all 21) About this table
| Compound |
-log (P-Val) |
Hits |
PubMed IDs for Articles with Shared Sentences (# sentences) |
| dbpa |
87.8 |
31 |
7651426 (6), 16243807 (4), 7628487 (3), 1923758 (3) (see all 10) |
| cisplatin |
41.8 |
49 |
18571458 (7), 12458343 (6), 18307537 (5), 12080043 (3) (see all 12) |
| selenocysteine |
39.8 |
6 |
9488664 (3), 10760958 (1) |
| etoposide |
32.8 |
2 |
17266041 (1), 9155152 (1) |
| agar |
28.4 |
8 |
15806160 (1), 19284373 (1), 19996271 (1), 18974106 (1) (see all 5) |
| camptothecin |
24.5 |
2 |
9155152 (1), 18307537 (1) |
| doxorubicin |
18.6 |
1 |
9155152 (1) |
| 5fluorouracil |
17.5 |
5 |
15750632 (3), 15703814 (1) |
| vegf |
16.2 |
4 |
16198352 (1), 16497437 (1), 17021746 (1) |
| estrogen |
15.1 |
6 |
18925950 (2), 18773210 (1), 20397575 (1), 15703814 (1) (see all 5) |
Search CenterWatch for drugs/clinical trials and news about YBX1 / YBOX1
|
Transcripts
for YBX1 gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for YBX1 gene: NM_004559.3 Unigene Cluster for YBX1: Y box binding protein 1 Hs.473583 [show with all ESTs]Unigene Representative Sequence: BM9078434 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000321358(uc001chs.3) ENST00000332220 ENST00000436427 ENST00000467957
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for YBX1 (see all 5)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for YBX1
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector: YBX1 (NM_004559) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for YBX1 | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat YBX1 |
Additional cDNA sequence: AK309996.1 AK311708.1 BC000064.2 BC002411.2 BC013838.1 BC015208.1 BC018393.1 BC020164.1 BC038384.1 BC065571.1 BC070084.1 BC071708.1 BC072014.1 BC090038.1 BC098435.1 BC106045.1 J03827.1 L28809.1 Z70765.1 24/81 DOTS entries (see all 81): DT.100710168 DT.100710149 DT.100875861 DT.97852954 DT.95313664 DT.95145401 DT.100710140 DT.91859349 DT.100710152 DT.100710161 DT.92051921 DT.100060019 DT.100710159 DT.100856136 DT.121441173 DT.100060016 DT.91679588 DT.100848665 DT.91959645 DT.121441020 DT.100060018 DT.102825761 DT.121441112 DT.92464131 24/1998 AceView cDNA sequences (see all 1998): BM820168 CB529563 BQ228555 BQ959785 BM706165 BM849989 AI816447 AW512168 BU193021 BM461545 BG025734 BU616237 BU192809 CB136155 BM974099 BU162783 BQ961608 BU615716 BQ440482 BM456033 BX429440 BM456953 BQ436332 CR597183
GeneLoc Exon Structure
|
Expression
for YBX1 gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| YBX1 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: GGGTTTTTAT
About this image
See YBX1 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for YBX1
SOURCE GeneReport for Unigene cluster: Hs.473583
SABiosciences Custom PCR Arrays for YBX1
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for YBX1
Browse OriGene validated miRNA SYBR primer pairs
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse, rat YBX1 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat YBX1 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat YBX1 | In Situ
Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for YBX1 |
Orthologs
for YBX1 gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of animals.
Orthologs for YBX1 gene from 5/21 species (see all 21) About this table
ENSEMBL Gene Tree for YBX1 (if available)
TreeFam Gene Tree for YBX1 (if available) |
Paralogs
for YBX1 gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| Paralogs for YBX1 gene
- YBX22 CSDA2
3 SIMAP similar genes for YBX1 using alignment to 6 protein entries: YBOX1_HUMAN (see all proteins):YB-1 CSDA YBX2
YBX1 for paralogs About GeneDecksing
5/9 Pseudogenes.org Pseudogenes for YBX1 (see all 9)
PGOHUM00000247142 PGOHUM00000240350 PGOHUM00000241021 PGOHUM00000238138 PGOHUM00000250901
|
Genomic Variants
for YBX1 gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 1 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for YBX1 (43148066 - 43168020 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV) variations for YBX1: -- | SABiosciences Cancer Mutation PCR Assays |
|
Disorders
/ Diseases
for YBX1 gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database, Novoseek,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
YBX1 for disorders About GeneDecksing
OMIM gene information: 154030
OMIM disorders: --
20/47  diseases for YBX1 (see all 47): About MalaCardsdiffuse large b-cell lymphoma dna topoisomerase ii b-cell lymphomas treacher collins syndrome
myxoid liposarcoma liposarcoma esophageal squamous cell carcinoma squamous cell carcinoma
embryonal rhabdomyosarcoma lupus erythematosus synovial sarcoma epithelial ovarian cancer
lyme disease werner syndrome brain glioma ovarian cancer
carcinoma cervical carcinoma rhabdomyosarcoma multiple myeloma
2 diseases from the University of Copenhagen DISEASES database for YBX1:Breast cancer Sarcoma 10/28 Novoseek disease relationships for YBX1 gene (see all 28) About this table
| Disease |
-log (P-Val) |
Hits |
PubMed IDs for Articles with Shared Sentences (# sentences) |
| breast cancer |
46.3 |
101 |
19284373 (6), 18925950 (6), 18974106 (5), 19930682 (5) (see all 31) |
| shock |
45 |
21 |
11069676 (2), 9409758 (1), 15494450 (1), 18224398 (1) (see all 18) |
| tumors |
42.1 |
126 |
16489918 (5), 10357417 (5), 19517610 (4), 18974106 (4) (see all 50) |
| cancer |
33.6 |
45 |
20079629 (4), 17418094 (4), 18773210 (4), 18172301 (2) (see all 23) |
| aggressiveness |
28.8 |
9 |
15703814 (2), 15735691 (1), 19411069 (1), 19901122 (1) (see all 5) |
| ovarian cancer |
23.9 |
14 |
12458343 (4), 17072343 (3), 16964697 (2), 17459055 (1) (see all 7) |
| nsclc |
18.1 |
23 |
11595709 (5), 16101161 (4), 19648825 (3), 14738225 (2) (see all 5) |
| glioblastoma |
17.4 |
3 |
16409125 (2), 17401009 (1) |
| liposarcoma |
16.2 |
1 |
12168660 (1) |
| breast carcinoma |
13.2 |
4 |
15899797 (1), 19713745 (1), 12565174 (1), 19411069 (1) |
Export disorders for YBX1 gene to outside databases
|
Publications
for YBX1 gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
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PubMed articles for YBX1 gene, integrated from 9 sources (see all 335):
(articles sorted by number of sources associating them with YBX1) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- Full length cDNA sequence encoding a nuclease-sensitive element DNA binding protein. (PubMed id 1891370)1, 2, 3 Kolluri R. and Kinniburgh A.J. (1991)
- Characterization of the cDNA encoding a protein binding to the major histocompatibility complex class II Y box. (PubMed id 3174636)1, 2, 3 Didier D.K.... Schwartz B.D. (1988)
- Splicing factor SRp30c interaction with Y-box protein-1 confers nuclear YB-1 shuttling and alternative splice site selection. (PubMed id 12604611)1, 2, 9 Raffetseder U.... Mertens P.R. (2003)
- YB-1 promotes strand separation in vitro of duplex DNA containing either mispaired bases or cisplatin modifications, exhibits endonucleolytic activities and binds several DNA repair proteins. (PubMed id 14718551)1, 2, 9 Gaudreault I.... Lebel M. (2004)
- Y-box protein-1 is actively secreted through a non-cl assical pathway and acts as an extracellular mitogen. (PubMed id 19483673)1, 2, 9 Frye B.C....Mertens P.R. (2009)
- Akt phosphorylates the Y-box binding protein 1 at Ser102 located in the cold shock domain and affects the anchorage-independent growth of breast cancer cells. (PubMed id 15806160)1, 2, 9 Sutherland B.W.... Dunn S.E. (2005)
- Nucleolin and YB-1 are required for JNK-mediated interleukin-2 mRNA stabilization during T-cell activation. (PubMed id 10817758)1, 2, 9 Chen C.-Y.... Karin M. (2000)
- A human protein containing a 'cold shock' domain binds specifically to H-DNA upstream from the human gamma-globin genes. (PubMed id 8188694)1, 2, 9 Horwitz E.M.... Ley T.J. (1994)
- Control of c-myc mRNA stability by IGF2BP1-associated cytoplasmic RNPs. (PubMed id 19029303)1, 2 Weidensdorfer D....HA1ttelmaier S. (2009)
- Rapid and systematic analysis of the RNA recognition specificities of RNA-binding proteins. (PubMed id 19561594)1, 2 Ray D....Hughes T.R. (2009)
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External Searches for YBX1 gene
(in PubMed,
OMIM, and NCBI Bookshelf)
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Genome Databases showing YBX1 gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
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Other Databases showing YBX1 gene
(According to HUGE)
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Specialized Databases showing YBX1 gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
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| Name | Description |
| PharmGKB entry for YBX1 | Pharmacogenomics, SNPs, Pathways |
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| Patent Information for YBX1 gene:
Search GeneIP for patents involving YBX1
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
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Products
for YBX1 gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
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