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Aliases for YBEY Gene

Aliases for YBEY Gene

  • YbeY Metallopeptidase (Putative) 2 3
  • C21orf57 3 4
  • Chromosome 21 Open Reading Frame 57 2
  • Putative Metalloprotease C21orf57 3
  • RRNA Maturation Factor Homolog 3
  • Putative Ribonuclease 3

External Ids for YBEY Gene

Previous Symbols for YBEY Gene

  • C21orf57

Summaries for YBEY Gene

GeneCards Summary for YBEY Gene

YBEY (YbeY Metallopeptidase (Putative)) is a Protein Coding gene. GO annotations related to this gene include metalloendopeptidase activity.

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for YBEY Gene

Genomics for YBEY Gene

Genomic Location for YBEY Gene

Start:
46,286,336 bp from pter
End:
46,313,102 bp from pter
Size:
26,767 bases
Orientation:
Plus strand

Genomic View for YBEY Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for YBEY Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for YBEY Gene

No data available for Regulatory Elements for YBEY Gene

Proteins for YBEY Gene

  • Protein details for YBEY Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P58557-YBEY_HUMAN
    Recommended name:
    Putative ribonuclease
    Protein Accession:
    P58557
    Secondary Accessions:
    • B7WPA9
    • B7WPF7
    • D3DSN2

    Protein attributes for YBEY Gene

    Size:
    167 amino acids
    Molecular mass:
    19298 Da
    Cofactor:
    Name=Zn(2+); Xref=ChEBI:CHEBI:29105; Note=Binds 1 zinc ion.;
    Quaternary structure:
    No Data Available
    Miscellaneous:
    • A protein of the expected size has been detected by antibody binding and Western blot in at least one of the analyzed tissues or cells.
    SequenceCaution:
    • Sequence=AAK74138.1; Type=Erroneous translation; Note=Wrong choice of CDS.; Evidence={ECO:0000305}; Sequence=AAK74139.1; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO:0000305}; Sequence=AAK74140.1; Type=Erroneous translation; Note=Wrong choice of CDS.; Evidence={ECO:0000305}; Sequence=AAK74141.1; Type=Erroneous translation; Note=Wrong choice of CDS.; Evidence={ECO:0000305};

    Alternative splice isoforms for YBEY Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for YBEY Gene

Proteomics data for YBEY Gene at MOPED

Post-translational modifications for YBEY Gene

No Post-translational modifications

Other Protein References for YBEY Gene

No data available for DME Specific Peptides for YBEY Gene

Domains for YBEY Gene

Protein Domains for YBEY Gene

UniProtKB/Swiss-Prot:

YBEY_HUMAN
Family:
  • Belongs to the endoribonuclease YbeY family.:
    • P58557
genes like me logo Genes that share domains with YBEY: view

No data available for Gene Families for YBEY Gene

Function for YBEY Gene

Gene Ontology (GO) - Molecular Function for YBEY Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004222 metalloendopeptidase activity IEA --
GO:0046872 metal ion binding IEA --
genes like me logo Genes that share ontologies with YBEY: view

No data available for Molecular function , Enzyme Numbers (IUBMB) , Phenotypes , Animal Models , miRNA , Transcription Factor Targeting and HOMER Transcription for YBEY Gene

Localization for YBEY Gene

Subcellular locations from UniProtKB/Swiss-Prot for YBEY Gene

Gene Ontology (GO) - Cellular Components for YBEY Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IDA 22042635
GO:0005654 nucleoplasm IDA --
GO:0005739 mitochondrion IEA --
genes like me logo Genes that share ontologies with YBEY: view

Pathways for YBEY Gene

SuperPathways for YBEY Gene

No Data Available

Gene Ontology (GO) - Biological Process for YBEY Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006364 rRNA processing IEA --
GO:0006508 proteolysis IEA --
genes like me logo Genes that share ontologies with YBEY: view

No data available for Pathways by source for YBEY Gene

Transcripts for YBEY Gene

mRNA/cDNA for YBEY Gene

(12) REFSEQ mRNAs :
(12) Additional mRNA sequences :
(8) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for YBEY Gene

YbeY metallopeptidase (putative):
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for YBEY Gene

ExUns: 1a · 1b ^ 2a · 2b ^ 3a · 3b ^ 4a · 4b · 4c ^ 5 ^ 6 ^ 7
SP1: - - - - -
SP2: - - - - - -
SP3: - - -
SP4: - - - -
SP5: - - - - - - -
SP6: - - - -
SP7: - - -
SP8: - -
SP9:

Relevant External Links for YBEY Gene

GeneLoc Exon Structure for
YBEY
ECgene alternative splicing isoforms for
YBEY

Expression for YBEY Gene

mRNA expression in normal human tissues for YBEY Gene

mRNA differential expression in normal tissues according to GTEx for YBEY Gene

This gene is overexpressed in Testis (5.6).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for YBEY Gene

SOURCE GeneReport for Unigene cluster for YBEY Gene Hs.474066

genes like me logo Genes that share expressions with YBEY: view

Orthologs for YBEY Gene

This gene was present in the common ancestor of chordates.

Orthologs for YBEY Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia YBEY 36
  • 99.4 (n)
  • 98.8 (a)
YBEY 37
  • 99 (a)
OneToOne
cow
(Bos Taurus)
Mammalia YBEY 36
  • 77.03 (n)
  • 73.78 (a)
YBEY 37
  • 73 (a)
OneToOne
dog
(Canis familiaris)
Mammalia YBEY 36
  • 73.17 (n)
  • 67.68 (a)
YBEY 37
  • 68 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Ybey 36
  • 82.32 (n)
  • 77.44 (a)
Ybey 16
Ybey 37
  • 77 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia YBEY 37
  • 69 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia YBEY 37
  • 75 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Ybey 36
  • 83.74 (n)
  • 79.88 (a)
chicken
(Gallus gallus)
Aves YBEY 37
  • 57 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia YBEY 37
  • 65 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia ybey 36
  • 60.83 (n)
  • 56.87 (a)
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.2303 36
zebrafish
(Danio rerio)
Actinopterygii LOC100537917 36
  • 61.28 (n)
  • 59.63 (a)
wufb30h03 36
ybey 37
  • 59 (a)
OneToMany
ybey 37
  • 59 (a)
OneToMany
Species with no ortholog for YBEY:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for YBEY Gene

ENSEMBL:
Gene Tree for YBEY (if available)
TreeFam:
Gene Tree for YBEY (if available)

Paralogs for YBEY Gene

Selected SIMAP similar genes for YBEY Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with YBEY: view

No data available for Paralogs for YBEY Gene

Variants for YBEY Gene

Sequence variations from dbSNP and Humsavar for YBEY Gene

SNP ID Clin Chr 21 pos Sequence Context AA Info Type MAF
rs8651 -- 46,297,702(-) TTATT(C/T)GTGTG utr-variant-3-prime, intron-variant
rs696327 -- 46,292,786(+) AGTTA(A/G)ACTCT intron-variant
rs697804 -- 46,292,620(+) AGTGG(A/G)GACAG downstream-variant-500B, intron-variant
rs697805 -- 46,292,622(+) TGGGG(A/T)CAGCC downstream-variant-500B, intron-variant
rs697806 -- 46,292,556(+) GCCAC(A/G)Caagt downstream-variant-500B, intron-variant

Structural Variations from Database of Genomic Variants (DGV) for YBEY Gene

Variant ID Type Subtype PubMed ID
nsv470910 CNV Gain 18288195
nsv519904 CNV Loss 19592680
nsv914134 CNV Gain 21882294
nsv527355 CNV Gain 19592680
nsv914135 CNV Loss 21882294
dgv4817n71 CNV Loss 21882294
nsv3547 CNV Insertion 18451855
nsv914139 CNV Gain 21882294
esv2320022 CNV Deletion 18987734
nsv821184 CNV Deletion 20802225
nsv914141 CNV Loss 21882294
esv27873 CNV Gain 19812545
esv1185684 CNV Insertion 17803354
esv1190668 CNV Deletion 17803354

Relevant External Links for YBEY Gene

HapMap Linkage Disequilibrium report
YBEY
Human Gene Mutation Database (HGMD)
YBEY

Disorders for YBEY Gene

No disorders were found for YBEY Gene.

No data available for UniProtKB/Swiss-Prot for YBEY Gene

Publications for YBEY Gene

  1. The DNA sequence of human chromosome 21. (PMID: 10830953) Hattori M. … Yaspo M.-L. (Nature 2000) 3 4
  2. From PREDs and open reading frames to cDNA isolation: revisiting the human chromosome 21 transcription map. (PMID: 11707072) Reymond A. … Antonarakis S.E. (Genomics 2001) 3 4
  3. Antibody-based protein profiling of the human chromosome 21. (PMID: 22042635) Uhlen M. … Sivertsson A. (Mol. Cell. Proteomics 2012) 3 4
  4. Proteomic analysis of the epidermal growth factor receptor (EGFR) interactome and post-translational modifications associated with receptor endocytosis in response to EGF and stress. (PMID: 24797263) Tong J. … Moran M.F. (Mol. Cell Proteomics 2014) 3
  5. Initial characterization of the human central proteome. (PMID: 21269460) Burkard T.R. … Colinge J. (BMC Syst. Biol. 2011) 4

Products for YBEY Gene

Sources for YBEY Gene

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