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Aliases for YBEY Gene

Aliases for YBEY Gene

  • YbeY Metallopeptidase (Putative) 2 3 5
  • C21orf57 3 4
  • Chromosome 21 Open Reading Frame 57 2
  • Putative Metalloprotease C21orf57 3
  • RRNA Maturation Factor Homolog 3

External Ids for YBEY Gene

Previous HGNC Symbols for YBEY Gene

  • C21orf57

Previous GeneCards Identifiers for YBEY Gene

  • GC21P047707

Summaries for YBEY Gene

Entrez Gene Summary for YBEY Gene

  • This gene encodes a highly conserved metalloprotein. A similar protein in bacteria acts as an endoribonuclease, and is thought to function in ribosomal RNA maturation and ribosome assembly. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Sep 2015]

GeneCards Summary for YBEY Gene

YBEY (YbeY Metallopeptidase (Putative)) is a Protein Coding gene. GO annotations related to this gene include metalloendopeptidase activity.

No data available for UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for YBEY Gene

Genomics for YBEY Gene

Regulatory Elements for YBEY Gene

Enhancers for YBEY Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around YBEY on UCSC Golden Path with GeneCards custom track

Promoters for YBEY Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around YBEY on UCSC Golden Path with GeneCards custom track

Genomic Location for YBEY Gene

46,286,310 bp from pter
46,313,225 bp from pter
26,916 bases
Plus strand

Genomic View for YBEY Gene

Genes around YBEY on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
YBEY Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for YBEY Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for YBEY Gene

Proteins for YBEY Gene

  • Protein details for YBEY Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Putative ribonuclease
    Protein Accession:
    Secondary Accessions:
    • B7WPA9
    • B7WPF7
    • D3DSN2

    Protein attributes for YBEY Gene

    167 amino acids
    Molecular mass:
    19298 Da
    Name=Zn(2+); Xref=ChEBI:CHEBI:29105;
    Quaternary structure:
    No Data Available
    • A protein of the expected size has been detected by antibody binding and Western blot in at least one of the analyzed tissues or cells.
    • Sequence=AAK74138.1; Type=Erroneous translation; Note=Wrong choice of CDS.; Evidence={ECO:0000305}; Sequence=AAK74139.1; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO:0000305}; Sequence=AAK74140.1; Type=Erroneous translation; Note=Wrong choice of CDS.; Evidence={ECO:0000305}; Sequence=AAK74141.1; Type=Erroneous translation; Note=Wrong choice of CDS.; Evidence={ECO:0000305};

    Alternative splice isoforms for YBEY Gene


neXtProt entry for YBEY Gene

Proteomics data for YBEY Gene at MOPED

Post-translational modifications for YBEY Gene

No Post-translational modifications

No data available for DME Specific Peptides for YBEY Gene

Domains & Families for YBEY Gene

Protein Domains for YBEY Gene

Suggested Antigen Peptide Sequences for YBEY Gene

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the endoribonuclease YbeY family.
  • Belongs to the endoribonuclease YbeY family.
genes like me logo Genes that share domains with YBEY: view

No data available for Gene Families for YBEY Gene

Function for YBEY Gene

Phenotypes for YBEY Gene

genes like me logo Genes that share phenotypes with YBEY: view

Animal Model Products

CRISPR Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for YBEY Gene

Localization for YBEY Gene

Subcellular locations from UniProtKB/Swiss-Prot for YBEY Gene

Subcellular locations from

Jensen Localization Image for YBEY Gene COMPARTMENTS Subcellular localization image for YBEY gene
Compartment Confidence
nucleus 5
mitochondrion 4

No data available for Gene Ontology (GO) - Cellular Components for YBEY Gene

Pathways & Interactions for YBEY Gene

SuperPathways for YBEY Gene

No Data Available

Gene Ontology (GO) - Biological Process for YBEY Gene


No data available for Pathways by source and SIGNOR curated interactions for YBEY Gene

Drugs & Compounds for YBEY Gene

No Compound Related Data Available

Transcripts for YBEY Gene

mRNA/cDNA for YBEY Gene

(17) REFSEQ mRNAs :
(12) Additional mRNA sequences :
(8) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for YBEY Gene

YbeY metallopeptidase (putative):
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for YBEY Gene

ExUns: 1a · 1b ^ 2a · 2b ^ 3a · 3b ^ 4a · 4b · 4c ^ 5 ^ 6 ^ 7
SP1: - - - - -
SP2: - - - - - -
SP3: - - -
SP4: - - - -
SP5: - - - - - - -
SP6: - - - -
SP7: - - -
SP8: - -

Relevant External Links for YBEY Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for YBEY Gene

mRNA expression in normal human tissues for YBEY Gene

mRNA differential expression in normal tissues according to GTEx for YBEY Gene

This gene is overexpressed in Testis (x5.6).

Protein differential expression in normal tissues from HIPED for YBEY Gene

This gene is overexpressed in Lung (49.7), Fetal ovary (10.2), and Testis (9.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for YBEY Gene

SOURCE GeneReport for Unigene cluster for YBEY Gene Hs.474066

genes like me logo Genes that share expression patterns with YBEY: view

Protein tissue co-expression partners for YBEY Gene

- Elite partner

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and mRNA Expression by UniProt/SwissProt for YBEY Gene

Orthologs for YBEY Gene

This gene was present in the common ancestor of chordates.

Orthologs for YBEY Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia YBEY 35
  • 77.03 (n)
  • 73.78 (a)
  • 73 (a)
(Canis familiaris)
Mammalia YBEY 35
  • 73.17 (n)
  • 67.68 (a)
  • 68 (a)
(Mus musculus)
Mammalia Ybey 35
  • 82.32 (n)
  • 77.44 (a)
Ybey 16
Ybey 36
  • 77 (a)
(Pan troglodytes)
Mammalia YBEY 35
  • 99.4 (n)
  • 98.8 (a)
  • 99 (a)
(Rattus norvegicus)
Mammalia Ybey 35
  • 83.74 (n)
  • 79.88 (a)
(Monodelphis domestica)
Mammalia YBEY 36
  • 69 (a)
(Ornithorhynchus anatinus)
Mammalia YBEY 36
  • 75 (a)
(Gallus gallus)
Aves YBEY 36
  • 57 (a)
(Anolis carolinensis)
Reptilia YBEY 36
  • 65 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia ybey 35
  • 60.83 (n)
  • 56.87 (a)
(Danio rerio)
Actinopterygii LOC100537917 35
  • 61.28 (n)
  • 59.63 (a)
wufb30h03 35
ybey 36
  • 59 (a)
ybey 36
  • 59 (a)
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.2303 35
Species with no ortholog for YBEY:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for YBEY Gene

Gene Tree for YBEY (if available)
Gene Tree for YBEY (if available)

Paralogs for YBEY Gene

(1) SIMAP similar genes for YBEY Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with YBEY: view

No data available for Paralogs for YBEY Gene

Variants for YBEY Gene

Sequence variations from dbSNP and Humsavar for YBEY Gene

SNP ID Clin Chr 21 pos Sequence Context AA Info Type
rs2276257 -- 46,291,315(+) AGTCT(A/G)CATTT intron-variant
rs4818832 -- 46,288,720(+) AATCA(C/T)GTAAA intron-variant
rs4819224 -- 46,288,685(+) aaaga(A/G)aaaaa intron-variant
rs4819225 -- 46,292,271(+) ggCTG(C/T)GTGAG intron-variant, downstream-variant-500B
rs4819226 -- 46,292,498(+) tctag(A/G)ttaaa intron-variant, downstream-variant-500B

Structural Variations from Database of Genomic Variants (DGV) for YBEY Gene

Variant ID Type Subtype PubMed ID
nsv470910 CNV Gain 18288195
nsv519904 CNV Loss 19592680
nsv914134 CNV Gain 21882294
nsv527355 CNV Gain 19592680
nsv914135 CNV Loss 21882294
dgv4817n71 CNV Loss 21882294
nsv3547 CNV Insertion 18451855
nsv914139 CNV Gain 21882294
esv2320022 CNV Deletion 18987734
nsv821184 CNV Deletion 20802225
nsv914141 CNV Loss 21882294
esv27873 CNV Gain 19812545
esv1185684 CNV Insertion 17803354
esv1190668 CNV Deletion 17803354

Variation tolerance for YBEY Gene

Residual Variation Intolerance Score: 47.3% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.22; 24.43% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for YBEY Gene

Human Gene Mutation Database (HGMD)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for YBEY Gene

Disorders for YBEY Gene

Relevant External Links for YBEY

Atlas of Genetics and Cytogenetics in Oncology and Haematology:

No disorders were found for YBEY Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for YBEY Gene

Publications for YBEY Gene

  1. Antibody-based protein profiling of the human chromosome 21. (PMID: 22042635) Uhlen M. … Sivertsson A. (Mol. Cell. Proteomics 2012) 3 4 67
  2. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 3
  3. Proteomic analysis of the epidermal growth factor receptor (EGFR) interactome and post-translational modifications associated with receptor endocytosis in response to EGF and stress. (PMID: 24797263) Tong J. … Moran M.F. (Mol. Cell Proteomics 2014) 3
  4. Genetic variants in nuclear-encoded mitochondrial genes influence AIDS progression. (PMID: 20877624) Hendrickson S.L. … O'Brien S.J. (PLoS ONE 2010) 3
  5. Protein interaction data set highlighted with human Ras-MAPK/PI3K signaling pathways. (PMID: 18624398) Wang J. … He F. (J. Proteome Res. 2008) 3

Products for YBEY Gene

Sources for YBEY Gene