Free for academic non-profit institutions. Other users need a Commercial license

Aliases for YBEY Gene

Aliases for YBEY Gene

  • YbeY Metallopeptidase (Putative) 2 3
  • C21orf57 3 4
  • Chromosome 21 Open Reading Frame 57 2
  • Putative Metalloprotease C21orf57 3
  • RRNA Maturation Factor Homolog 3
  • Putative Ribonuclease 3

External Ids for YBEY Gene

Previous HGNC Symbols for YBEY Gene

  • C21orf57

Previous GeneCards Identifiers for YBEY Gene

  • GC21P047707

Summaries for YBEY Gene

GeneCards Summary for YBEY Gene

YBEY (YbeY Metallopeptidase (Putative)) is a Protein Coding gene. GO annotations related to this gene include metalloendopeptidase activity.

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for YBEY Gene

Genomics for YBEY Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for YBEY Gene

46,286,336 bp from pter
46,313,102 bp from pter
26,767 bases
Plus strand

Genomic View for YBEY Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for YBEY Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for YBEY Gene

No data available for Regulatory Elements for YBEY Gene

Proteins for YBEY Gene

  • Protein details for YBEY Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Putative ribonuclease
    Protein Accession:
    Secondary Accessions:
    • B7WPA9
    • B7WPF7
    • D3DSN2

    Protein attributes for YBEY Gene

    167 amino acids
    Molecular mass:
    19298 Da
    Name=Zn(2+); Xref=ChEBI:CHEBI:29105; Note=Binds 1 zinc ion.;
    Quaternary structure:
    No Data Available
    • A protein of the expected size has been detected by antibody binding and Western blot in at least one of the analyzed tissues or cells.
    • Sequence=AAK74138.1; Type=Erroneous translation; Note=Wrong choice of CDS.; Evidence={ECO:0000305}; Sequence=AAK74139.1; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO:0000305}; Sequence=AAK74140.1; Type=Erroneous translation; Note=Wrong choice of CDS.; Evidence={ECO:0000305}; Sequence=AAK74141.1; Type=Erroneous translation; Note=Wrong choice of CDS.; Evidence={ECO:0000305};

    Alternative splice isoforms for YBEY Gene


neXtProt entry for YBEY Gene

Proteomics data for YBEY Gene at MOPED

Post-translational modifications for YBEY Gene

No Post-translational modifications

Other Protein References for YBEY Gene

No data available for DME Specific Peptides for YBEY Gene

Domains for YBEY Gene

Protein Domains for YBEY Gene

Suggested Antigen Peptide Sequences for YBEY Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • P58557
  • Belongs to the endoribonuclease YbeY family.
genes like me logo Genes that share domains with YBEY: view

No data available for Gene Families for YBEY Gene

Function for YBEY Gene

Gene Ontology (GO) - Molecular Function for YBEY Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004222 metalloendopeptidase activity IEA --
GO:0046872 metal ion binding IEA --
genes like me logo Genes that share ontologies with YBEY: view

Animal Model Products

CRISPR Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Phenotypes , Animal Models , miRNA , Transcription Factor Targeting and HOMER Transcription for YBEY Gene

Localization for YBEY Gene

Subcellular locations from UniProtKB/Swiss-Prot for YBEY Gene

Gene Ontology (GO) - Cellular Components for YBEY Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IDA 22042635
GO:0005654 nucleoplasm IDA --
GO:0005739 mitochondrion IEA --
genes like me logo Genes that share ontologies with YBEY: view

No data available for Subcellular locations from COMPARTMENTS for YBEY Gene

Pathways for YBEY Gene

SuperPathways for YBEY Gene

No Data Available

Gene Ontology (GO) - Biological Process for YBEY Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006364 rRNA processing IEA --
GO:0006508 proteolysis IEA --
genes like me logo Genes that share ontologies with YBEY: view

No data available for Pathways by source for YBEY Gene

Transcripts for YBEY Gene

mRNA/cDNA for YBEY Gene

(12) REFSEQ mRNAs :
(12) Additional mRNA sequences :
(8) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for YBEY Gene

YbeY metallopeptidase (putative):
Representative Sequences:

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for YBEY

Primer Products

  • OriGene qSTAR qPCR primer pairs in human,mouse,rat for YBEY

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for YBEY Gene

ExUns: 1a · 1b ^ 2a · 2b ^ 3a · 3b ^ 4a · 4b · 4c ^ 5 ^ 6 ^ 7
SP1: - - - - -
SP2: - - - - - -
SP3: - - -
SP4: - - - -
SP5: - - - - - - -
SP6: - - - -
SP7: - - -
SP8: - -

Relevant External Links for YBEY Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for YBEY Gene

mRNA expression in normal human tissues for YBEY Gene

mRNA differential expression in normal tissues according to GTEx for YBEY Gene

This gene is overexpressed in Testis (5.6).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for YBEY Gene

SOURCE GeneReport for Unigene cluster for YBEY Gene Hs.474066

genes like me logo Genes that share expressions with YBEY: view

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and mRNA Expression by UniProt/SwissProt for YBEY Gene

Orthologs for YBEY Gene

This gene was present in the common ancestor of chordates.

Orthologs for YBEY Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia YBEY 35
  • 99.4 (n)
  • 98.8 (a)
  • 99 (a)
(Bos Taurus)
Mammalia YBEY 35
  • 77.03 (n)
  • 73.78 (a)
  • 73 (a)
(Canis familiaris)
Mammalia YBEY 35
  • 73.17 (n)
  • 67.68 (a)
  • 68 (a)
(Mus musculus)
Mammalia Ybey 35
  • 82.32 (n)
  • 77.44 (a)
Ybey 16
Ybey 36
  • 77 (a)
(Monodelphis domestica)
Mammalia YBEY 36
  • 69 (a)
(Ornithorhynchus anatinus)
Mammalia YBEY 36
  • 75 (a)
(Rattus norvegicus)
Mammalia Ybey 35
  • 83.74 (n)
  • 79.88 (a)
(Gallus gallus)
Aves YBEY 36
  • 57 (a)
(Anolis carolinensis)
Reptilia YBEY 36
  • 65 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia ybey 35
  • 60.83 (n)
  • 56.87 (a)
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.2303 35
(Danio rerio)
Actinopterygii LOC100537917 35
  • 61.28 (n)
  • 59.63 (a)
wufb30h03 35
ybey 36
  • 59 (a)
ybey 36
  • 59 (a)
Species with no ortholog for YBEY:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for YBEY Gene

Gene Tree for YBEY (if available)
Gene Tree for YBEY (if available)

Paralogs for YBEY Gene

Selected SIMAP similar genes for YBEY Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with YBEY: view

No data available for Paralogs for YBEY Gene

Variants for YBEY Gene

Sequence variations from dbSNP and Humsavar for YBEY Gene

SNP ID Clin Chr 21 pos Sequence Context AA Info Type MAF
rs8651 -- 46,297,702(-) TTATT(C/T)GTGTG utr-variant-3-prime, intron-variant
rs696327 -- 46,292,786(+) AGTTA(A/G)ACTCT intron-variant
rs697804 -- 46,292,620(+) AGTGG(A/G)GACAG downstream-variant-500B, intron-variant
rs697805 -- 46,292,622(+) TGGGG(A/T)CAGCC downstream-variant-500B, intron-variant
rs697806 -- 46,292,556(+) GCCAC(A/G)Caagt downstream-variant-500B, intron-variant

Structural Variations from Database of Genomic Variants (DGV) for YBEY Gene

Variant ID Type Subtype PubMed ID
nsv470910 CNV Gain 18288195
nsv519904 CNV Loss 19592680
nsv914134 CNV Gain 21882294
nsv527355 CNV Gain 19592680
nsv914135 CNV Loss 21882294
dgv4817n71 CNV Loss 21882294
nsv3547 CNV Insertion 18451855
nsv914139 CNV Gain 21882294
esv2320022 CNV Deletion 18987734
nsv821184 CNV Deletion 20802225
nsv914141 CNV Loss 21882294
esv27873 CNV Gain 19812545
esv1185684 CNV Insertion 17803354
esv1190668 CNV Deletion 17803354

Relevant External Links for YBEY Gene

HapMap Linkage Disequilibrium report
Human Gene Mutation Database (HGMD)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for YBEY Gene

Disorders for YBEY Gene

No disorders were found for YBEY Gene.

No data available for UniProtKB/Swiss-Prot for YBEY Gene

Publications for YBEY Gene

  1. The DNA sequence of human chromosome 21. (PMID: 10830953) Hattori M. … Yaspo M.-L. (Nature 2000) 3 4
  2. From PREDs and open reading frames to cDNA isolation: revisiting the human chromosome 21 transcription map. (PMID: 11707072) Reymond A. … Antonarakis S.E. (Genomics 2001) 3 4
  3. Antibody-based protein profiling of the human chromosome 21. (PMID: 22042635) Uhlen M. … Sivertsson A. (Mol. Cell. Proteomics 2012) 3 4
  4. Proteomic analysis of the epidermal growth factor receptor (EGFR) interactome and post-translational modifications associated with receptor endocytosis in response to EGF and stress. (PMID: 24797263) Tong J. … Moran M.F. (Mol. Cell Proteomics 2014) 3
  5. Initial characterization of the human central proteome. (PMID: 21269460) Burkard T.R. … Colinge J. (BMC Syst. Biol. 2011) 4

Products for YBEY Gene

Sources for YBEY Gene

Back to Top