YBEY Gene
protein-coding GIFtS: 41
GCID: GC21P047707
|
|
ybeY metallopeptidase (putative)(Previous name: chromosome 21 open reading frame 57 )
(Previous symbol: C21orf57)
| |
Aliases
for YBEY gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| YbeY Metallopeptidase (Putative)1 2 | | C21orf571 2 3 | | Chromosome 21 Open Reading Frame 571 | | Putative Metalloprotease C21orf572 | | RRNA Maturation Factor Homolog2 |
Export aliases for YBEY gene to outside databases |
Summaries
for YBEY gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
-- |
Genomic Views
for YBEY gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000021.8 NC_018932.1 NT_011515.12
Regulatory elements:
 Search SABiosciences Regulatory transcription factor binding sites for YBEY
Other transcription factors
Search SABiosciences Chromatin IP Primers for YBEY
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat YBEY |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 21q22.3 Ensembl cytogenetic band: 21q22.3 HGNC cytogenetic band: 21q22.3YBEY Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 21 GeneLoc Exon Structure GeneLoc location for GC21P047707: view genomic region
(about GC identifiers)
Start:
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47,706,251 bp from pter |
End:
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47,717,665 bp from pter |
Size:
|
11,415 bases |
Orientation:
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plus strand |
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Proteins
for YBEY gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: YBEY_HUMAN, P58557 (See
protein sequence)Recommended Name: Putative ribonuclease Size: 167 amino acids; 19298 Da
Cofactor: Binds 1 zinc ion (By similarity)
Subcellular location: Nucleus
Miscellaneous: A protein of the expected size has been detected by antibody binding and Western blot in at least one ofthe analyzed tissues or cells (PubMed:22042635)
Sequence caution: Sequence=AAK74138.1; Type=Erroneous translation; Note=Wrong choice of CDS; Sequence=AAK74139.1;Type=Erroneous initiation; Note=Translation N-terminally shortened; Sequence=AAK74140.1; Type=Erroneous translation;Note=Wrong choice of CDS; Sequence=AAK74141.1; Type=Erroneous translation; Note=Wrong choice of CDS;
Secondary accessions: B7WPA9 B7WPF7 D3DSN2Alternative splicing: 4 isoforms: P58557-1 P58557-2 P58557-3 P58557-4 Explore the universe of human proteins at neXtProt for YBEY: NX_P58557
YBEY Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins (2 alternative transcripts):
NP_001006114.1 NP_478061.1
ENSEMBL proteins: ENSP00000380813 ENSP00000380808 ENSP00000329614 ENSP00000340675 ENSP00000380806 ENSP00000380805
Human Recombinant Protein Products:
Gene Ontology (GO): 2 cellular component terms (GO ID links to tree view): About this table
YBEY for ontologies About GeneDecksing
YBEY Antibody Products:
Assay Products for YBEY: |
Protein
Domains /
Families
for YBEY gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
YBEY for domains About GeneDecksing
3 InterPro domains/families:Graphical View of Domain Structure for InterPro Entry P58557ProtoNet protein and cluster: P58557 1 Blocks protein family: IPB002036 Protein of unknown function UPF0054
UniProtKB/Swiss-Prot: YBEY_HUMAN, P58557Similarity: Belongs to the endoribonuclease YbeY family |
Function
for YBEY gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Clone
Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for YBEY (see all 4)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for YBEY (see all 2)
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling 
| |  | GenScript: all cDNA clones in your preferred vector (see all 2): YBEY (NM_058181) | |  | Browse Sino Biological Human cDNA Clones | |  | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for YBEY | |  | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat YBEY |
In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for YBEY |
Gene Ontology (GO): 2 molecular function terms (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0004222 | metalloendopeptidase activity |
IEA | -- | | GO:0046872 | metal ion binding |
IEA | -- |
YBEY for ontologies About GeneDecksing
|
Pathways & Interactions
for YBEY gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Interactions:
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for YBEY
STRING Interaction
Network Preview (showing 3 interactants - click image to see more details)
3 Interacting proteins for YBEY (P585573 ENSP000003296144) via UniProtKB, MINT, STRING, and/or I2DAbout this table
|
Drugs & Compounds
for YBEY gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
 Browse Tocris compounds for YBEY
Search CenterWatch for drugs/clinical trials and news about YBEY
|
Transcripts
for YBEY gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for YBEY gene (2 alternative transcripts): NM_001006114.1 NM_058181.1 Unigene Cluster for YBEY: YbeY metallopeptidase (putative) Hs.474066 [show with all ESTs]Unigene Representative Sequence: AK2949758 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000397701(uc002ziw.3 uc002zix.3 uc010gqh.3) ENST00000468924
ENST00000397694 ENST00000329319(uc002ziv.3) ENST00000339195(uc002ziy.3)
ENST00000397692 ENST00000492864(uc002zit.1 uc002ziu.1) ENST00000397691
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for YBEY (see all 4)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for YBEY (see all 2)
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector (see all 2): YBEY (NM_058181) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for YBEY | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat YBEY |
Additional cDNA sequence: AK128875.1 AK294975.1 AY040873.1 AY040874.1 AY040875.1 AY040876.1 BC022828.1 BC068100.1 BC119770.1 BC122865.1 BC131553.1 DQ786290.1 10 DOTS entries: DT.442093 DT.100750019 DT.121134432 DT.97823524 DT.100750018 DT.92417452 DT.91879059 DT.412085 DT.99975493 DT.87046385
GeneLoc Exon Structure
5/9 Alternative Splicing Database (ASD) splice patterns (SP) for YBEY (see all 9) About this scheme
| ExUns: | 1a | · | 1b | ^ | 2a | · | 2b | ^ | 3a | · | 3b | ^ | 4a | · | 4b | · | 4c | ^ | 5 | ^ | 6 | ^ | 7 |
|---|
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| SP1: | | | | | - | | - | | | | | | | | - | | - | | - | | | | | | |
| SP2: | | | | | - | | - | | | | - | | | | - | | - | | - | | | | | | |
| SP3: | | | | | | | | | | | | | | | - | | - | | - | | | | | | |
| SP4: | | | | | - | | - | | | | | | | | - | | - | | | | | | | | |
| SP5: | | | | | - | | - | | | | - | | - | | - | | - | | - | | | | | |
ECgene alternative splicing isoforms for YBEY
|
Expression
for YBEY gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| YBEY expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: AGCATCTGAA
About this image
See YBEY Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for YBEY
SOURCE GeneReport for Unigene cluster: Hs.474066
SABiosciences Custom PCR Arrays for YBEY
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for YBEY
Browse OriGene validated miRNA SYBR primer pairs
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse, rat YBEY | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat YBEY | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat YBEY | In Situ
Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for YBEY |
Orthologs
for YBEY gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the last universal common ancestor (LUCA).
Orthologs for YBEY gene from 6/20 species (see all 20) About this table
| Organism |
Taxonomic
classification |
Gene |
Description |
Human
Similarity |
Orthology
Type |
Details |
mouse
(Mus musculus) |
Mammalia |
Ybey1 , 5 |
ybeY metallopeptidase1, 5 |
82.32(n)1
77.44(a)1 |
|
10 (38.85 cM)5
2161191 NM_172550.41 NP_766138.31
764595695 |
lizard
(Anolis carolinensis) |
Reptilia |
YBEY6 |
-- |
64(a) |
1 ↔ 1 |
1(123000604-123006001) |
African clawed frog
(Xenopus laevis) |
Amphibia |
BG731038.12 |
-- |
80.84(n) |
|
BG731038.1 |
zebrafish
(Danio rerio) |
Actinopterygii |
wufb30h032 |
Transcribed sequence with weak similarity to protein more |
72.8(n) |
|
BG985784.1 |
honey bee
(Apis mellifera) |
Insecta |
-- |
-- |
15(a) |
1 ↔ 1 |
GroupUn.1765(837-1316) |
E. coli
(Escherichia coli) |
Gamma proteobacteria |
ybeY6 |
metal-binding heat shock protein required for rRNA... |
21(a) |
1 ↔ 1 |
Chromosome(691097-691564) |
ENSEMBL Gene Tree for YBEY (if available)
TreeFam Gene Tree for YBEY (if available) |
Paralogs
for YBEY gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| -- |
Genomic Variants
for YBEY gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 21 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for YBEY (47706251 - 47717665 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV) variations for YBEY: -- | SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing YBEY |
|
Disorders
/ Diseases
for YBEY gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
YBEY for disorders About GeneDecksing
3  diseases for YBEY: About MalaCardspneumonia tuberculosis mycobacterium tuberculosis
Export disorders for YBEY gene to outside databases
|
Publications
for YBEY gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for YBEY gene integrated from 9 sources:
(articles sorted by number of sources associating them with YBEY) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- From PREDs and open reading frames to cDNA isolation: revisiting the human chromosome 21 transcription map. (PubMed id 11707072)1, 2 Reymond A....Antonarakis S.E. (2001)
- The DNA sequence of human chromosome 21. (PubMed id 10830953)1, 2 Hattori M....Yaspo M.L. (2000)
- Antibody-based protein profiling of the human chromosome 21. (PubMed id 22042635)2 Uhlen M....Sivertsson A. (2012)
- Initial characterization of the human central proteome. (PubMed id 21269460)2 Burkard T.R.... Colinge J. (2011)
- Genetic variants in nuclear-encoded mitochondrial gen es influence AIDS progression. (PubMed id 20877624)1 Hendrickson S.L....O'Brien S.J. (2010)
- Protein interaction data set highlighted with human Ras-MAPK/PI3K signaling pathways. (PubMed id 18624398)1 Wang J....He F. (2008)
- Transcriptome analysis of human gastric cancer. (PubMed id 16341674)1 Oh J.H....Kim N.S. (2005)
- Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (2002)
|
External Searches for YBEY gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
|
Genome Databases showing YBEY gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing YBEY gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing YBEY gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
| Name | Description |
| PharmGKB entry for YBEY | Pharmacogenomics, SNPs, Pathways |
|
| | |
About This Section
| Patent Information for YBEY gene:
Search GeneIP for patents involving YBEY
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for YBEY gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
About This Section
|
 | |
 | |
 |
| | |  | Browse OriGene Antibodies | | Browse OriGene shRNA RFPs | | | OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for YBEY | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for YBEY | | | OriGene Protein Over-expression Lysate for YBEY | | Browse OriGene Fluorogenic Cell Assay Kits | | | OriGene siRNA for YBEY | | OriGene 3'-UTR Clone for YBEY | | | OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for YBEY | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for YBEY | | | Browse OriGene GFP tagged cDNA clones in CMV expression vector | | Browse OriGene MicroRNA Expression Plasmids | | | Browse OriGene basic RS shRNAs | | Browse OriGene validated miRNA SYBR primer pairs | | | Browse OriGene full length recombinant human proteins expressed in human HEK293 cells | | OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling | | | OriGene Custom Antibody Services for YBEY | | OriGene Custom Protein Services for YBEY | | | OriGene Custom Immunoassay Development | | |
| |
 |
 |
| | | QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat YBEY | | | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing YBEY | | | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat YBEY | | | QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat YBEY | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat YBEY | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat YBEY |
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 |  |  |  | |
| | | | Search Tocris compounds for YBEY |
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 | | | YBEY Proteins, Antibodies, CLIAs, and ELISAs |
| | | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for YBEY |
|  |  |  | | | | Search ThermoFisher Antibodies for YBEY |
| | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat YBEY |
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