Aliases for YARS2 Gene
External Ids for YARS2 Gene
Previous GeneCards Identifiers for YARS2 Gene
This gene encodes a mitochondrial protein that catalyzes the attachment of tyrosine to tRNA(Tyr). Mutations in this gene are associated with myopathy with lactic acidosis and sideroblastic anemia type 2 (MLASA2). [provided by RefSeq, Jan 2011]
GeneCards Summary for YARS2 Gene
YARS2 (Tyrosyl-TRNA Synthetase 2, Mitochondrial) is a Protein Coding gene. Diseases associated with YARS2 include myopathy, lactic acidosis, and sideroblastic anemia 2 and mitochondrial myopathy and sideroblastic anemia 1. Among its related pathways are Gene Expression and tRNA Aminoacylation. GO annotations related to this gene include protein homodimerization activity and tyrosine-tRNA ligase activity.
UniProtKB/Swiss-Prot for YARS2 Gene
Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction: tyrosine is first activated by ATP to form Tyr-AMP and then transferred to the acceptor end of tRNA(Tyr).