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Aliases & Descriptions for YARS2
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc
, and/or 7Ensembl,
8miRBase) About This Section
|
| Aliases |
|---|
| CGI-04 1, 2 | | EC 6.1.1.1 3 | | FLJ13995 1, 2 | | TYRRS 2 | | TyrRS 3 | | mt-TyrRS 1, 2 |
| | | Descriptions |
|---|
| Tyrosine--tRNA ligase 3 | | tyrosine tRNA ligase 2, mitochondrial 2 | | tyrosyl-tRNA synthetase 2, mitochondrial 2 |
|
| | Search outside databases for aliases for YARS2 gene |
Summaries for YARS2(According to Entrez Gene,
Wikipedia's
Gene Wiki,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
| UniProtKB/Swiss-Prot: SYYM_HUMAN, Q9Y2Z4Function: Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction: tyrosine is first activated by ATP to form Tyr-AMP and then transferred to the acceptor end of tRNA(Tyr) (By similarity) |
Genomic Location for YARS2
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 36),
and/or miRBase,
Genomic Views according to
UCSC and
Ensembl,
Transcription factor binding sites according to
SABiosciences) About This Section
| Genomic View: UCSC Golden Path with GeneCards custom track
Transcription factor binding sites upstream to the YARS2 gene 
Entrez Gene cytogenetic band: 12p11.21 Ensembl cytogenetic band: 12p11.21 HGNC cytogenetic band: 12p11.21YARS2 Gene in genomic location: bands according to Ensembl, locations according to
(and/or Entrez Gene and/or Ensembl if different)
 GeneLoc gene densities for chromosome 12 GeneLoc Exon Structure GeneLoc location for GC12M032789:
(about GC identifiers)
Start:
|
32,790,726 bp from pter |
End:
|
32,800,141 bp from pter |
Size:
|
9,416 bases |
Orientation:
|
minus strand |
RefSeq DNA sequence:- NC_000012.10 NT_009714.16
| Proteins for YARS2
(According to
1UniProtKB,
and/or Ensembl,
Phosphorylation sites according to 2Phosphosite,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from Invitrogen,
Millipore,
Sigma-Aldrich,
R&D Systems,
Enzo Life Sciences,
Abnova,
OriGene and/or,
Abcam,
Biochemical Assays by
Invitrogen,
Millipore,
R&D Systems,
Cell Signaling Technology, and/or
Enzo Life Sciences,
Ontologies according to Gene
Ontology Consortium 01 Apr 2009 and
Entrez Gene,
Antibodies by Invitrogen,
Millipore,
Sigma-Aldrich,
R&D Systems,
Cell Signaling Technology,
Abcam,
Abnova, and/or
Novus Biologicals)
About This Section
| UniProtKB/Swiss-Prot: SYYM_HUMAN, Q9Y2Z4 (See
protein sequence)Recommended Name: Tyrosyl-tRNA synthetase, mitochondrial precursor Size: 477 amino acids; 53199 Da
Subunit: Homodimer
Subcellular location: Mitochondrion matrix
PDB structures from and Proteopedia :2PID (3D)
 
Secondary accessions: Q9H817Post-translational modifications:
View phosphorylation sites using PhosphoSite2
REFSEQ proteins: NP_001035526.1
ENSEMBL proteins: ENSP00000320658
Human Recombinant Proteins Browse Origene for full length recombinant human proteins expressed in human HEK293 cells 
3 Gene Ontology (GO) cellular component terms (links to tree view): About this table
Antibodies for YARS2: Assays for YARS2: | Protein
Domains/ Families for YARS2(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
| - Graphical View of Domain Structure for InterPro Entry Q9Y2Z4
ProtoNet protein and cluster: Q9Y2Z4 1 Blocks protein family: IPB002307 Tyrosyl-tRNA synthetase signature
UniProtKB/Swiss-Prot: SYYM_HUMAN, Q9Y2Z4Similarity: Belongs to the class-I aminoacyl-tRNA synthetase family | Gene Function for YARS2
(According to MGI Jun 06 2009, UniProtKB,
IUBMB,and/or Genatlas,
shRNA from
OriGene,
Sigma-Aldrich, RNAi from
Sigma-Aldrich,
RNAi Products,
Clones, and
Q-PCR Products
from Invitrogen,
Millipore,
OriGene, and/or
Abnova,
siRNAs from
Applied Biosystems,
SYBR primers from OriGene,
Cell-based Assays from Millipore,
Ontologies according to Gene Ontology Consortium 01 Apr 2009 via
Entrez Gene.)
About This Section
|                OriGene 29mer shRNA kit in GFP-retroviral vectors (see all 2): NM_001040436
Applied Biosystems Silencer® siRNAs for YARS2
Sigma-Aldrich siRNA for YARS2  Sigma-Aldrich shRNA for YARS2  Explore Sigma-Aldrich super-pooled esiRNAs 
              OriGene GFP tagged cDNA clone in CMV expression vector: NM_001040436                                  Myc/DDK tagged cDNA clone in CMV expression vector: NM_001040436                                  untagged cDNA clone in CMV expression vector: NM_001040436 
Primers: Browse
Quantitative PCR Central at Invitrogen for Q-PCR LUX™ Primers               OriGene genome-wide validated SYBR primer pairs: NM_001040436
UniProtKB/Swiss-Prot: SYYM_HUMAN, Q9Y2Z4Function: Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction: tyrosine is first activated by ATP to form Tyr-AMP and then transferred to the acceptor end of tRNA(Tyr) (By similarity)Catalytic activity: ATP + L-tyrosine + tRNA(Tyr) = AMP + diphosphate + L-tyrosyl-tRNA(Tyr)Enzyme Number (IUBMB): EC 6.1.1.1 5 Gene Ontology (GO) molecular function terms (links to tree view): About this table | Pathways & Interactions for YARS2
(Pathways according to Invitrogen
(maps by GeneGo),
Millipore,
Cell Signaling Technology,
Sigma-Aldrich,
KEGG
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Proteins Network according to
SABiosciences,
Interactions according to 1UniProtKB,
2MINT, and/or
3STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Apr 2009 via
Entrez Gene.)
About This Section
| 2 Sigma-Aldrich "Your Favorite Gene" Pathways for YARS2 (Your Favorite Gene powered by Ingenuity) 
5/11 Interacting proteins for YARS2 (Q9Y2Z41 ENSP000003206583) via UniProtKB, MINT, and/or STRING (see all 11
)About this table
1 Gene Ontology (GO) biological process term (links to tree view): | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0006437 | tyrosyl-tRNA aminoacylation |
IEA | -- | About this table
|
Drugs & Compounds for YARS2(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
Sigma-Aldrich, Tocris Bioscience, and/or
Novoseek and Drugs according to
Enzo Life Sciences and/or
PharmGKB)
About This Section
|
Browse Tocris compounds for YARS2 1 Novoseek chemical compound relationship for YARS2 gene
| Compound |
Score |
Articles |
PubMed IDs for Articles with Shared Sentences (# sentences) |
| tyrosine |
36.66 |
1 |
18268021 (1) |
About this table
|
Transcripts for YARS2(GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 219 Homo sapiens; Jun 2 2009) or GenBank, RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
non coding RNAs according to
RNAdb,
ESTs according to GeneTide,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from Invitrogen,
Millipore, and/or
Abnova,
siRNAs from Applied Biosystems,
Sigma-Aldrich,
shRNA from
Sigma-Aldrich,
OriGene,
Tagged/untagged cDNA clones from
OriGene, Expression Assays from Applied Biosystems) About This Section
|                OriGene 29mer shRNA kit in GFP-retroviral vectors (see all 2): NM_001040436
Sigma-Aldrich siRNA for YARS2  Sigma-Aldrich shRNA for YARS2  Explore Sigma-Aldrich super-pooled esiRNAs 
Applied Biosystems Silencer® siRNAs: NM_001040436 REFSEQ mRNAs for YARS2 gene: NM_001040436.1
Applied Biosystems TaqMan ® Gene Expression Assays: NM_001040436               OriGene GFP tagged cDNA clone in CMV expression vector: NM_001040436                                  Myc/DDK tagged cDNA clone in CMV expression vector: NM_001040436                                  untagged cDNA clone in CMV expression vector: NM_001040436  Additional cDNA sequence: AK024057.1 AK026619.1 AK130935.1 BC015625.2 CR599422.1 CR600056.1 CR602460.1 CR603090.1 CR613924.1 CR616684.1 CR621180.1 8 DOTS entries: DT.100766389 DT.100811471 DT.100811473 DT.101982967 DT.100811476 DT.92036555 DT.100656281 DT.455783 24/169 AceView cDNA sequences (see all 169
):AL550526 BX115035 CR616684 AI658738 AA514792 CR603090 BM788583 AW237063 BX426353 AA947985 AA903035 BU624190 BQ690039 AI200199 BQ935733 BI093579 BE873633 BF590565 CR621180 AA576313 AL556461 BQ948022 BU616843 N69226
highest scoring ESTs for YARS2:AA305890 AA341406 AA625298 AK024057 AK026619 AL520131 AL552956 AL556461 AL576181 AL578710 Unigene Cluster for YARS2: Tyrosyl-tRNA synthetase 2, mitochondrial Hs.505231 [show with all ESTs]Unigene Representative Sequence: NM_001040436
GeneLoc Exon Structure
2 Alternative Splicing Database (ASD) splice patterns (SP) for YARS2
| ExUns: | 1a | · | 1b | ^ | 2 | ^ | 3a | · | 3b | ^ | 4a | · | 4b | ^ | 5 | |
| SP1: | |   | |   | |   | |   | |   | |   | |   | |   | |
| SP2: | |   | |   | |   | - |   | |   | |   | |   | |   |
About this scheme
ECgene alternative splicing isoforms for YARS2
1 Ensembl transcript including schematic representation: ENST00000324868
|
Expression for YARS2
(Experimental results according to
1GeneNote
and GNF BioGPS,
probe sets-to-genes annotations according to
2GeneAnnot ,
3GeneTide ,
Sets of similar genes according to GeneDecks,
Electronic Northern calculations according to data from
UniGene (Build 219 Homo sapiens),
SAGE tags according to
CGAP,
plus additional links to
SOURCE, and/or
GNF
BioGPS, and/or
EXPOLDB, and/or
UniProtKB,
Expression Assays from
Applied Biosystems
)
About This Section
| YARS2 expression in normal and diseased human tissues
Applied Biosystems TaqMan ® Gene Expression Assays for YARS2
1 / 2 / 3 5 probe-sets matching YARS2 gene Data from
(Publications) and GNF BioGPS About these images About these images
CGAP SAGE TAG: TCTGATCAGG
SOURCE GeneReport for Unigene cluster: Hs.505231
|
Orthologs for YARS2
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
and/or
5MGI Jun 06 2009,
with possible further links to
Flybase
and/or
WormBase,
Gene Trees according to Ensembl)
About This Section
|
Orthologs for YARS2 gene from 5/21 species (see all 21
)
About this table Species with no ortholog for YARS2
ENSEMBL Gene Tree for YARS2 | Paralogs for YARS2(Paralogs according to 1HomoloGene and 2Ensembl, Pseudogenes according to 3Pseudogene.org) About This Section
| -- |
SNPs/Variants for YARS2(According to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE, and
UniProtKB,
Linkage Disequilibrium by HapMap,
Genotyping Reagents from
Applied Biosystems)
About This Section
|
HapMap Linkage Disequilibrium images for YARS2 (up to first 250kb)
|
Disorders & Mutations for YARS2
(in which this Gene is Involved, According to
OMIM, UniProtKB,
PharmGKB,
Genatlas, GeneTests,
Blood group antigen gene mutations by BGMUT,
HGMD, GAD,
HuGE Navigator,
BCGD,
and/or TGDB.)
About This Section
|
OMIM: 610957
|
Medical News for YARS2(Possibly Related Articles in
Doctor's Guide)
About This Section
| -- |
Publications for YARS2 (in
PubMed.
Associations of this gene to articles via
1Novoseek,
2HGNC,
3Entrez Gene,
4UniProtKB/Swiss-Prot,
5UniProtKB/TrEMBL,
6GAD, and/or
7PharmGKB)
About This Section
| 10/26 PubMed articles for YARS2 gene (see all 26
):- Toward the full set of human mitochondrial aminoacyl-tRNA synthetases: characterization of AspRS and TyrRS. (PubMed id 15779907)2, 3, 4 Bonnefond L....Sissler M. (2005)
- Human mitochondrial TyrRS disobeys the tyrosine identity rules. (PubMed id 15840810)2, 3 Bonnefond L....Rudinger-Thirion J. (2005)
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)3, 4 Gerhard D.S....Malek J. (2004)
- Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)3, 4 Ota T....Sugano S. (2004)
- Identification of novel human genes evolutionarily conserved in Caenorhabditis elegans by comparative proteomics. (PubMed id 10810093)3, 4 Lai C.H....Lin W. (2000)
- Crystal structure of human mitochondrial tyrosyl-tRNA synthetase reveals common and idiosyncratic features. (PubMed id 17997975)1, 3 Bonnefond L....Rudinger-Thirion J. (2007)
- Automated phosphoproteome analysis for cultured cancer cells by two- dimensional nanoLC-MS using a calcined titania/C18 biphasic column. (PubMed id 18187866)4 Imami K.... Ishihama Y. (2008)
- Violating the splicing rules: TG dinucleotides function as alternative 3' splice sites in U2-dependent introns. (PubMed id 17672918)3 Szafranski K....Platzer M. (2007)
- Large-scale mapping of human protein-protein interactions by mass spectrometry. (PubMed id 17353931)3 Ewing R.M....Figeys D. (2007)
- Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)3 Strausberg R.L....Marra M.A. (2002)
|
Search for YARS2
(in PubMed,
OMIM, and NCBI Bookshelf) About This Section
|
|
Genome Databases showing YARS2
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
and/or
H-InvDB)
About This Section
|
| Other Databases showing YARS2
(According to HUGE)
About This Section
| -- |
Specialized Databases showing YARS2(According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL, Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot) About This Section
|
| About This Section
| --
| Services for YARS2(Reagents available from Applied Biosystems, Antibodies and assays by Cell
Signaling Technology, Abcam, Novus Biologicals, Sigma-Aldrich, R&D Systems, Millipore, Abnova, and/or Invitrogen, Clones available from OriGene,and/or Invitrogen, Drugs and/or compounds by Sigma-Aldrich, Enzo Life Sciences, and/or Tocris Bioscience) About This Section
| 
 Products for YARS2:

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Incremental update: 13 Oct 2009
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