Aliases for YARS Gene
External Ids for YARS Gene
Previous GeneCards Identifiers for YARS Gene
Aminoacyl-tRNA synthetases catalyze the aminoacylation of tRNA by their cognate amino acid. Because of their central role in linking amino acids with nucleotide triplets contained in tRNAs, aminoacyl-tRNA synthetases are thought to be among the first proteins that appeared in evolution. Tyrosyl-tRNA synthetase belongs to the class I tRNA synthetase family. Cytokine activities have also been observed for the human tyrosyl-tRNA synthetase, after it is split into two parts, an N-terminal fragment that harbors the catalytic site and a C-terminal fragment found only in the mammalian enzyme. The N-terminal fragment is an interleukin-8-like cytokine, whereas the released C-terminal fragment is an EMAP II-like cytokine. [provided by RefSeq, Jul 2008]
GeneCards Summary for YARS Gene
YARS (Tyrosyl-TRNA Synthetase) is a Protein Coding gene. Diseases associated with YARS include Charcot-Marie-Tooth Disease, Dominant Intermediate C and Myopathy, Lactic Acidosis, And Sideroblastic Anemia 2. Among its related pathways are tRNA Aminoacylation and Gene Expression. GO annotations related to this gene include poly(A) RNA binding and signal transducer activity.
UniProtKB/Swiss-Prot for YARS Gene
Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction: tyrosine is first activated by ATP to form Tyr-AMP and then transferred to the acceptor end of tRNA(Tyr).