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Aliases for YARS Gene

Aliases for YARS Gene

  • Tyrosyl-TRNA Synthetase 2 3 4
  • TYRRS 3 4 6
  • EC 6.1.1.1 4 63
  • CMTDIC 3 6
  • YRS 3 6
  • YTS 3 6
  • Tyrosyl-TRNA Synthetase, Cytoplasmic 3
  • Tyrosine TRNA Ligase 1, Cytoplasmic 3
  • Tyrosine--TRNA Ligase, Cytoplasmic 3
  • Tyrosine TRNA Ligase 1 2
  • Tyrosyl--TRNA Ligase 3
  • Cytoplasmic 2
  • EC 6.1.1 63

External Ids for YARS Gene

Previous GeneCards Identifiers for YARS Gene

  • GC01M033060
  • GC01M032195
  • GC01M032667
  • GC01M032909
  • GC01M033013
  • GC01M033240
  • GC01M031356

Summaries for YARS Gene

Entrez Gene Summary for YARS Gene

  • Aminoacyl-tRNA synthetases catalyze the aminoacylation of tRNA by their cognate amino acid. Because of their central role in linking amino acids with nucleotide triplets contained in tRNAs, aminoacyl-tRNA synthetases are thought to be among the first proteins that appeared in evolution. Tyrosyl-tRNA synthetase belongs to the class I tRNA synthetase family. Cytokine activities have also been observed for the human tyrosyl-tRNA synthetase, after it is split into two parts, an N-terminal fragment that harbors the catalytic site and a C-terminal fragment found only in the mammalian enzyme. The N-terminal fragment is an interleukin-8-like cytokine, whereas the released C-terminal fragment is an EMAP II-like cytokine. [provided by RefSeq, Jul 2008]

GeneCards Summary for YARS Gene

YARS (Tyrosyl-TRNA Synthetase) is a Protein Coding gene. Diseases associated with YARS include charcot-marie-tooth disease, dominant intermediate c and intermediate charcot-marie-tooth neuropathy. Among its related pathways are Gene Expression and tRNA Aminoacylation. GO annotations related to this gene include signal transducer activity and tyrosine-tRNA ligase activity.

UniProtKB/Swiss-Prot for YARS Gene

  • Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction: tyrosine is first activated by ATP to form Tyr-AMP and then transferred to the acceptor end of tRNA(Tyr).

Gene Wiki entry for YARS Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for YARS Gene

Genomics for YARS Gene

Regulatory Elements for YARS Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for YARS Gene

Start:
32,775,237 bp from pter
End:
32,818,153 bp from pter
Size:
42,917 bases
Orientation:
Minus strand

Genomic View for YARS Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for YARS Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for YARS Gene

Proteins for YARS Gene

  • Protein details for YARS Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P54577-SYYC_HUMAN
    Recommended name:
    Tyrosine--tRNA ligase, cytoplasmic
    Protein Accession:
    P54577
    Secondary Accessions:
    • B3KWK4
    • D3DPQ4
    • O43276
    • Q53EN1

    Protein attributes for YARS Gene

    Size:
    528 amino acids
    Molecular mass:
    59143 Da
    Quaternary structure:
    • Homodimer.
    SequenceCaution:
    • Sequence=AAB39406.1; Type=Frameshift; Positions=354; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for YARS Gene

neXtProt entry for YARS Gene

Proteomics data for YARS Gene at MOPED

Post-translational modifications for YARS Gene

  • Ubiquitination at Lys119, Lys147, Lys197, Lys206, and Lys513
  • Modification sites at PhosphoSitePlus

Other Protein References for YARS Gene

ENSEMBL proteins:
Reactome Protein details:
REFSEQ proteins:

Domains for YARS Gene

Gene Families for YARS Gene

HGNC:
  • aaRS1 :Aminoacyl tRNA synthetases / Class I

Suggested Antigen Peptide Sequences for YARS Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

P54577

UniProtKB/Swiss-Prot:

SYYC_HUMAN :
  • P54577
Domain:
  • Contains 1 tRNA-binding domain.
Family:
  • Belongs to the class-I aminoacyl-tRNA synthetase family.
genes like me logo Genes that share domains with YARS: view

Function for YARS Gene

Molecular function for YARS Gene

UniProtKB/Swiss-Prot CatalyticActivity: ATP + L-tyrosine + tRNA(Tyr) = AMP + diphosphate + L-tyrosyl-tRNA(Tyr)
UniProtKB/Swiss-Prot Function: Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction: tyrosine is first activated by ATP to form Tyr-AMP and then transferred to the acceptor end of tRNA(Tyr).

Enzyme Numbers (IUBMB) for YARS Gene

Gene Ontology (GO) - Molecular Function for YARS Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000049 tRNA binding IEA --
GO:0000166 nucleotide binding --
GO:0004812 aminoacyl-tRNA ligase activity --
GO:0004822 NOT isoleucine-tRNA ligase activity IBA --
GO:0004831 tyrosine-tRNA ligase activity TAS --
genes like me logo Genes that share ontologies with YARS: view

Phenotypes for YARS Gene

GenomeRNAi human phenotypes for YARS:
genes like me logo Genes that share phenotypes with YARS: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for YARS

In Situ Assay Products

Flow Cytometry Products

No data available for Animal Models , Transcription Factor Targeting and HOMER Transcription for YARS Gene

Localization for YARS Gene

Subcellular locations from UniProtKB/Swiss-Prot for YARS Gene

Cytoplasm.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for YARS Gene COMPARTMENTS Subcellular localization image for YARS gene
Compartment Confidence
cytosol 4
extracellular 4
nucleus 4
mitochondrion 1

Gene Ontology (GO) - Cellular Components for YARS Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005615 extracellular space TAS 10102815
GO:0005634 nucleus IDA --
GO:0005737 cytoplasm IDA --
GO:0005829 cytosol TAS --
genes like me logo Genes that share ontologies with YARS: view

Pathways for YARS Gene

genes like me logo Genes that share pathways with YARS: view

Pathways by source for YARS Gene

1 KEGG pathway for YARS Gene
1 GeneGo (Thomson Reuters) pathway for YARS Gene

PCR Array Products

  • Pathway & Disease-focused RT² Profiler PCR Arrays

Gene Ontology (GO) - Biological Process for YARS Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006418 tRNA aminoacylation for protein translation TAS --
GO:0006428 NOT isoleucyl-tRNA aminoacylation IBA --
GO:0006437 tyrosyl-tRNA aminoacylation IEA --
GO:0006915 apoptotic process TAS 10102815
GO:0007165 signal transduction NAS 10102815
genes like me logo Genes that share ontologies with YARS: view

Compounds for YARS Gene

(5) HMDB Compounds for YARS Gene

Compound Synonyms Cas Number PubMed IDs
Adenosine monophosphate
  • 5'-AMP
61-19-8
Adenosine triphosphate
  • 5'-(tetrahydrogen triphosphate) Adenosine
56-65-5
L-Tyrosine
  • (-)-a-Amino-p-hydroxyhydrocinnamate
60-18-4
Phosphoric acid
  • acide phosphorique (FRENCH)
7664-38-2
Pyrophosphate
  • (4-)Diphosphoric acid ion
14000-31-8

(1) Drugbank Compounds for YARS Gene

Compound Synonyms Cas Number Type Actions PubMed IDs
Tyrosinal
target

(10) Novoseek inferred chemical compound relationships for YARS Gene

Compound -log(P) Hits PubMed IDs
aminoacyl-trna 87.5 3
trna(tyr) 84.4 4
trna 73.6 20
anticodon 52 2
tyrosine 47.5 10
genes like me logo Genes that share compounds with YARS: view

Transcripts for YARS Gene

mRNA/cDNA for YARS Gene

(8) Additional mRNA sequences :
(1) Selected AceView cDNA sequences:
(3) REFSEQ mRNAs :
(10) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for YARS Gene

Tyrosyl-tRNA synthetase:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for YARS

Primer Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for YARS Gene

ExUns: 1 ^ 2 ^ 3 ^ 4a · 4b ^ 5 ^ 6 ^ 7a · 7b ^ 8a · 8b · 8c ^ 9a · 9b · 9c ^ 10 ^ 11 ^ 12a · 12b ^ 13 ^ 14a · 14b
SP1: - - - - - -
SP2: -
SP3:
SP4:
SP5: - -
SP6:

Relevant External Links for YARS Gene

GeneLoc Exon Structure for
YARS
ECgene alternative splicing isoforms for
YARS

Expression for YARS Gene

mRNA expression in normal human tissues for YARS Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for YARS Gene

SOURCE GeneReport for Unigene cluster for YARS Gene Hs.213264

genes like me logo Genes that share expressions with YARS: view

In Situ Assay Products

No data available for mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for YARS Gene

Orthologs for YARS Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for YARS Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia YARS 35
  • 99.68 (n)
  • 99.81 (a)
YARS 36
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia YARS 35
  • 91.35 (n)
  • 94.32 (a)
YARS 36
  • 95 (a)
OneToOne
dog
(Canis familiaris)
Mammalia YARS 35
  • 92.11 (n)
  • 95.64 (a)
YARS 36
  • 90 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Yars 35
  • 89.52 (n)
  • 96.59 (a)
Yars 16
Yars 36
  • 97 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia YARS 36
  • 92 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia YARS 36
  • 83 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Yars 35
  • 89.27 (n)
  • 95.08 (a)
chicken
(Gallus gallus)
Aves YARS 35
  • 78.12 (n)
  • 87.29 (a)
YARS 36
  • 87 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia YARS 36
  • 85 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia Str.4835 35
yars 35
  • 73.42 (n)
  • 79.55 (a)
zebrafish
(Danio rerio)
Actinopterygii yars 35
  • 73.93 (n)
  • 82.01 (a)
yars 36
  • 82 (a)
OneToOne
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP003003 35
  • 61.9 (n)
  • 62.4 (a)
fruit fly
(Drosophila melanogaster)
Insecta Aats-tyr 35
  • 65.61 (n)
  • 69.7 (a)
Aats-tyr 36
  • 67 (a)
OneToOne
CG4561 37
  • 67 (a)
worm
(Caenorhabditis elegans)
Secernentea Y105E8A.19 36
  • 32 (a)
OneToOne
Y105E8A.19 37
  • 68 (a)
A. gosspyii yeast
(Ashbya gossypii)
Saccharomycetes AGOS_AAL148W 35
  • 60.62 (n)
  • 59.94 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes TYS1 35
  • 59.84 (n)
  • 58.48 (a)
TYS1 36
  • 51 (a)
OneToOne
TYS1 38
K. lactis yeast
(Kluyveromyces lactis)
Saccharomycetes KLLA0F15389g 35
  • 57.7 (n)
  • 56.3 (a)
corn
(Zea mays)
Liliopsida Zm.4638 35
rice
(Oryza sativa)
Liliopsida Os04g0303900 35
  • 53.73 (n)
  • 45.9 (a)
bread mold
(Neurospora crassa)
Ascomycetes NCU07755 35
  • 54.24 (n)
  • 50.91 (a)
fission yeast
(Schizosaccharomyces pombe)
Schizosaccharomycetes yrs1 35
  • 57.32 (n)
  • 56.37 (a)
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.10401 35
sea squirt
(Ciona savignyi)
Ascidiacea CSA.1744 36
  • 66 (a)
OneToOne
Species with no ortholog for YARS:
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for YARS Gene

ENSEMBL:
Gene Tree for YARS (if available)
TreeFam:
Gene Tree for YARS (if available)

Paralogs for YARS Gene

No data available for Paralogs for YARS Gene

Variants for YARS Gene

Sequence variations from dbSNP and Humsavar for YARS Gene

SNP ID Clin Chr 01 pos Sequence Context AA Info Type MAF
rs699002 -- 32,785,083(+) ttagc(A/T)ttgta intron-variant
rs699003 -- 32,783,405(-) tgagc(C/T)cagga intron-variant
rs699004 -- 32,782,196(-) TGTAC(A/C)GGCAT intron-variant
rs699005 -- 32,780,201(+) TGTAC(C/G)AGGCC synonymous-codon, reference
rs785415 -- 32,786,138(-) TTAAT(A/G)CAGAT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for YARS Gene

Variant ID Type Subtype PubMed ID
nsv519188 CNV Loss 19592680
nsv509158 CNV Insertion 20534489
nsv322 CNV Loss 18451855

Relevant External Links for YARS Gene

HapMap Linkage Disequilibrium report
YARS
Human Gene Mutation Database (HGMD)
YARS

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for YARS Gene

Disorders for YARS Gene

(1) OMIM Diseases for YARS Gene (603623)

UniProtKB/Swiss-Prot

SYYC_HUMAN
  • Charcot-Marie-Tooth disease, dominant, intermediate type, C (CMTDIC) [MIM:608323]: A form of Charcot-Marie-Tooth disease, a disorder of the peripheral nervous system, characterized by progressive weakness and atrophy, initially of the peroneal muscles and later of the distal muscles of the arms. The dominant intermediate type C is characterized by clinical and pathologic features intermediate between demyelinating and axonal peripheral neuropathies, and motor median nerve conduction velocities ranging from 25 to 45 m/sec. {ECO:0000269 PubMed:16429158}. Note=The disease is caused by mutations affecting the gene represented in this entry.

(1) University of Copenhagen DISEASES for YARS Gene

(1) Novoseek inferred disease relationships for YARS Gene

Disease -log(P) Hits PubMed IDs
charcot-marie-tooth disease 48.7 1
genes like me logo Genes that share disorders with YARS: view

Publications for YARS Gene

  1. Human tyrosyl-tRNA synthetase shares amino acid sequence homology with a putative cytokine. (PMID: 9162081) Kleeman T.A. … First E.A. (J. Biol. Chem. 1997) 2 3 4 23
  2. Crystal structure of a human aminoacyl-tRNA synthetase cytokine. (PMID: 12427973) Yang X.-L. … Schimmel P. (Proc. Natl. Acad. Sci. U.S.A. 2002) 3 4 23
  3. Crystal structures that suggest late development of genetic code components for differentiating aromatic side chains. (PMID: 14671330) Yang X.-L. … Ribas de Pouplana L. (Proc. Natl. Acad. Sci. U.S.A. 2003) 3 4 23
  4. Evidence that two present-day components needed for the genetic code appeared after nucleated cells separated from eubacteria. (PMID: 8552597) Ribas de Pouplana L. … Schimmel P. (Proc. Natl. Acad. Sci. U.S.A. 1996) 2 3 4
  5. Toward the full set of human mitochondrial aminoacyl-tRNA synthetases: characterization of AspRS and TyrRS. (PMID: 15779907) Bonnefond L. … Sissler M. (Biochemistry 2005) 3 23

Products for YARS Gene

Sources for YARS Gene

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