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YARS Gene

protein-coding GIFtS: 63

GC01M033013

tyrosyl-tRNA synthetase
Symbol approved by the HUGO Gene Nomenclature Committee (HGNC) database

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc , and/or ⁷Ensembl, ⁸miRBase)
About This Section

Aliases
CMTDIC ^², ⁵
EC 6.1.1.1 ^³
OTTHUMP00000004027 ^²
TYRRS ^², ⁵
TyrRS ^³
YRS ^¹, ², ⁵
YTS ^¹, ², ⁵
tyrRS ^¹

Descriptions
Tyrosyl--tRNA ligase ^³
tyrosine tRNA ligase 1, cytoplasmic ^²
tyrosyl-tRNA synthetase ^²

External Ids
HGNC: 12840¹
Entrez Gene: 8565²
UniProtKB: P54577³
Ensembl: ENSG00000134684⁷

Search outside databases for aliases for YARS gene

Previous GC identifers: GC01M033060 GC01M032195 GC01M032667 GC01M032743 GC01M032909

(According to Entrez Gene, Wikipedia's Gene Wiki,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

EntrezGene summary for YARS:

Aminoacyl-tRNA synthetases catalyze the aminoacylation of tRNA by their cognate amino acid. Because

of their central role in linking amino acids with nucleotide triplets contained in tRNAs,

aminoacyl-tRNA synthetases are thought to be among the first proteins that appeared in evolution.

Tyrosyl-tRNA synthetase belongs to the class I tRNA synthetase family. Cytokine activities have

also been observed for the human tyrosyl-tRNA synthetase, after it is split into two parts, an

N-terminal fragment that harbors the catalytic site and a C-terminal fragment found only in the

mammalian enzyme. The N-terminal fragment is an interleukin-8-like cytokine, whereas the released

C-terminal fragment is an EMAP II-like cytokine. [provided by RefSeq]

UniProtKB/Swiss-Prot: SYYC_HUMAN, P54577

Function: Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction: tyrosine is

first activated by ATP to form Tyr-AMP and then transferred to the acceptor end of tRNA(Tyr) (By

similarity)

Gene Wiki entry for YARS

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 36),
and/or miRBase,
Genomic Views according to UCSC and Ensembl, Transcription factor binding sites according to SABiosciences)
About This Section

Genomic View:

UCSC Golden Path with GeneCards custom track

Transcription factor binding sites upstream to the YARS gene

Entrez Gene cytogenetic band: 1p35.1 Ensembl cytogenetic band: 1p35.1 HGNC cytogenetic band: 1p35.1

YARS Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)

GeneLoc gene densities for chromosome 1 GeneLoc Exon Structure

GeneLoc location for GC01M033013: (about GC identifiers)

Start:	33,013,427 bp from pter
End:	33,056,220 bp from pter
Size:	42,794 bases
Orientation:	minus strand

RefSeq DNA sequence:

NC_000001.9 NT_032977.8

(According to ¹UniProtKB, and/or Ensembl, Phosphorylation sites according to ²Phosphosite, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Enzo Life Sciences, Abnova, OriGene and/or, Abcam,
Biochemical Assays by Invitrogen, Millipore, R&D Systems, Cell Signaling Technology, and/or Enzo Life Sciences, Ontologies according to Gene Ontology Consortium 01 Apr 2009 and Entrez Gene, Antibodies by Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Cell Signaling Technology, Abcam, Abnova, and/or Novus Biologicals)
About This Section

UniProtKB/Swiss-Prot: SYYC_HUMAN, P54577 (See protein sequence)

Recommended Name: Tyrosyl-tRNA synthetase, cytoplasmic

Size: 528 amino acids; 59143 Da

Subunit: Homodimer

Subcellular location: Cytoplasm

Sequence caution: Sequence=AAB39406.1; Type=Frameshift; Positions=354;

PDB structures from and Proteopedia :

1N3L (3D)

1NTG (3D)

1Q11 (3D)

Secondary accessions: O43276 Q53EN1

Post-translational modifications:

View phosphorylation sites using PhosphoSite²

REFSEQ proteins: NP_003671.1

ENSEMBL proteins:

ENSP00000362576

Human Recombinant Proteins

	Browse Drug Discovery Central at Invitrogen for human recombinant proteins
	Browse Purified and Recombinant Proteins at Millipore
	Browse Human Recombinant Proteins at Sigma-Aldrich
	Browse R&D Systems for human recombinant proteins
	Browse recombinant and purified proteins available from Enzo Life Sciences
	Recombinant Proteins from Abcam (Tyrosyl tRNA synthetase)
	Human Recombinant Proteins from Abnova (YARS)

Browse Origene for full length recombinant human proteins expressed in human HEK293 cells

3 Gene Ontology (GO) cellular component terms (links to tree view):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005615	extracellular space	TAS	10102815
GO:0005625	soluble fraction	TAS	9162081
GO:0005737	cytoplasm	TAS	9162081

About this table

Antibodies for YARS:

	Browse Antibodies Central at Invitrogen
	Browse Millipore's Extensive Line of Mono- and Polyclonal Antibodies
	Sigma-Aldrich Antibodies for YARS
	Browse R&D Systems for Antibodies
	Antibodies from Abcam (Tyrosyl tRNA synthetase), each with their Abpromise^SM
	Monoclonal and Polyclonal Antibodies from Abnova (YARS)
	Novus Biologicals Antibodies for YARS

Assays for YARS:

	Browse Invitrogen for biochemical assays
	Browse Kits and Assays available from Millipore
	Browse R&D Systems for biochemical assays
	Browse biochemical assays available from Enzo Life Sciences

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

Graphical View of Domain Structure for InterPro Entry P54577

ProtoNet protein and cluster: P54577

3 Blocks protein families:

IPB002305 Aminoacyl-tRNA synthetase

IPB002307 Tyrosyl-tRNA synthetase signature

IPB002547 t-RNA-binding region

UniProtKB/Swiss-Prot: SYYC_HUMAN, P54577

Similarity: Belongs to the class-I aminoacyl-tRNA synthetase family

Similarity: Contains 1 tRNA-binding domain

(According to MGI Jun 06 2009, UniProtKB, IUBMB,and/or Genatlas,
shRNA from OriGene, Sigma-Aldrich, RNAi from Sigma-Aldrich,
RNAi Products, Clones, and Q-PCR Products from Invitrogen, Millipore, OriGene, and/or Abnova, siRNAs from Applied Biosystems, SYBR primers from OriGene, Cell-based Assays from Millipore, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
About This Section

Inhib. RNA:		Invitrogen RNAi Products for gene knock-down (YARS)
		Browse for Gene Knock-down Tools from Millipore
		Abnova Chimera RNAi Products for Gene knock-down (YARS)

OriGene 29mer shRNA kit in GFP-retroviral vector: NM_003680

Applied Biosystems Silencer® siRNAs for YARS

Sigma-Aldrich siRNA for YARS

Sigma-Aldrich shRNA for YARS

Explore Sigma-Aldrich super-pooled esiRNAs

Clones:		Browse Clone Ranger at Invitrogen for clones
		Browse Clones for the Expression of Recombinant Proteins Available from Millipore

OriGene GFP tagged cDNA clone in CMV expression vector: NM_003680
Myc/DDK tagged cDNA clone in CMV expression vector: NM_003680
untagged cDNA clones in CMV expression vector (see all 2): NM_003680

Primers:

Browse Quantitative PCR Central at Invitrogen for Q-PCR LUX™ Primers

OriGene genome-wide validated SYBR primer pairs: NM_003680

UniProtKB/Swiss-Prot: SYYC_HUMAN, P54577

Function: Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction: tyrosine is

first activated by ATP to form Tyr-AMP and then transferred to the acceptor end of tRNA(Tyr) (By

similarity)

Catalytic activity: ATP + L-tyrosine + tRNA(Tyr) = AMP + diphosphate + L-tyrosyl-tRNA(Tyr)

Enzyme Number (IUBMB): EC 6.1.1.1

5/8 Gene Ontology (GO) molecular function terms (links to tree view) (see all 8 ):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0000049	tRNA binding	IEA	--
GO:0000166	nucleotide binding	IEA	--
GO:0004831	tyrosine-tRNA ligase activity	TAS	9162081
GO:0004871	signal transducer activity	NAS	10102815
GO:0005153	interleukin-8 receptor binding	TAS	10102815

About this table

(Pathways according to Invitrogen (maps by GeneGo), Millipore, Cell Signaling Technology, Sigma-Aldrich, KEGG and/or UniProtKB,
Sets of similar genes according to GeneDecks, Proteins Network according to SABiosciences, Interactions according to ¹UniProtKB, ²MINT, and/or ³STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
About This Section

2 Sigma-Aldrich "Your Favorite Gene" Pathways for YARS (Your Favorite Gene powered by Ingenuity)

Phenylalanine, Tyrosine and Tryptophan Biosynthesis
Aminoacyl-tRNA Biosynthesis

GeneDecks YARS for the pathways selected above

About GeneDecksing

5/25 Interacting proteins for YARS (P54577¹ ENSP00000362576³) via UniProtKB, MINT, and/or STRING (see all 25 )

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
ARF6	P62330¹	EBI-1048893, EBI-638181
EIF1B	O60739¹	EBI-1048893, EBI-1043343
EIF6	P56537¹	EBI-1048893, EBI-372243
SAP18	O00422¹	EBI-1048893, EBI-1044156
YARS2	ENSP00000320658³	STRING (score=.978)

About this table

2 Gene Ontology (GO) biological process terms (links to tree view):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0006437	tyrosyl-tRNA aminoacylation	TAS	9162081
GO:0006915	apoptosis	TAS	10102815

About this table

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, Sigma-Aldrich, Tocris Bioscience, and/or Novoseek and Drugs according to Enzo Life Sciences and/or PharmGKB)
About This Section

Browse drugs & compounds from Enzo Life Sciences

Browse Small Molecules at Sigma-Aldrich

Browse Tocris compounds for YARS
10 Novoseek chemical compound relationships for YARS gene

Compound	Score	Articles	PubMed IDs for Articles with Shared Sentences (# sentences)
aminoacyl-trna	87.18	3	7743129 (1), 15779907 (1), 17401211 (1)
trna(tyr)	84.91	4	10630994 (4)
trna	74.67	45	9162081 (7), 7743129 (2), 18560823 (2), 12450387 (2) (see all 11)
anticodon	53.41	3	15130561 (1), 12427973 (1)
tyrosine	49.18	10	11856731 (4), 12016229 (2), 9057892 (1), 10630994 (1) (see all 6)
hydrogen	22.38	1	18560823 (1)
atp	18.39	7	12016229 (2), 18560823 (2), 7711024 (1), 12473451 (1)
gtp	10.82	1	7530051 (1)
lysine	5.02	1	12016229 (1)
potassium	0.00	3	11856731 (2), 12016229 (1)

About this table

(GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 219 Homo sapiens; Jun 2 2009) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView,
non coding RNAs according to RNAdb,
ESTs according to GeneTide,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from Invitrogen, Millipore, and/or Abnova,
siRNAs from Applied Biosystems, Sigma-Aldrich,
shRNA from Sigma-Aldrich, OriGene,
Tagged/untagged cDNA clones from OriGene,
Expression Assays from Applied Biosystems)
About This Section

Inhib. RNA:		Invitrogen RNAi Products for gene knock-down (YARS)
		Browse for Gene Knock-down Tools from Millipore
		Abnova Chimera RNAi Products for Gene knock-down (YARS)

OriGene 29mer shRNA kit in GFP-retroviral vector: NM_003680

Sigma-Aldrich siRNA for YARS

Sigma-Aldrich shRNA for YARS

Explore Sigma-Aldrich super-pooled esiRNAs

Applied Biosystems Silencer® siRNAs:

NM_003680

REFSEQ mRNAs for YARS gene:

NM_003680.3

Applied Biosystems TaqMan ® Gene Expression Assays:

NM_003680

              OriGene GFP tagged cDNA clone in CMV expression vector: NM_003680
                                 Myc/DDK tagged cDNA clone in CMV expression vector: NM_003680
                                 untagged cDNA clones in CMV expression vector (see all 2): NM_003680

Additional cDNA sequence:

AK026535.1 AK125213.1 AK223608.1 BC001933.1 BC004151.2 BC016689.1 CR622576.1 CR626320.1

U40714.1 U89436.1

24/42 DOTS entries (see all 42 ):

DT.40291549 DT.100877451 DT.95168272 DT.100877446 DT.95168270 DT.318916 DT.100877456 DT.100877466

DT.40121470 DT.431953 DT.121452224 DT.121452370 DT.121452219 DT.121452391 DT.95335382 DT.99986548

DT.100877447 DT.121452364 DT.70100695 DT.100044946 DT.121452312 DT.100877472 DT.101971391 DT.75132549

1 AceView cDNA sequence:

AK127879

highest scoring ESTs for YARS:

U89436 AA307563 AU077088 AW249253 BE256528 BE294655 BF102544 BI227347 BM560131 BQ360410

Unigene Cluster for YARS:

Tyrosyl-tRNA synthetase

Hs.706890 [show with all ESTs]

Unigene Representative Sequence: AK125213

GeneLoc Exon Structure

5/6 Alternative Splicing Database (ASD) splice patterns (SP) for YARS (see all 6 )

ExUns:	1	^	2	^	3	^	4a	·	4b	^	5	^	6	^	7a	·	7b	^	8a	·	8b	·	8c	^	9a	·	9b	·	9c	^	10	^	11	^	12a	·	12b	^	13	^	14a	·	14b
SP1:			-												-								-		-				-						-
SP2:																													-
SP3:
SP4:
SP5:																							-		-

About this scheme

ECgene alternative splicing isoforms for YARS

1 Ensembl transcript including schematic representation:

ENST00000373477

(Experimental results according to ¹GeneNote and GNF BioGPS,
probe sets-to-genes annotations according to ²GeneAnnot , ³GeneTide , Sets of similar genes according to GeneDecks, Electronic Northern calculations according to data from UniGene (Build 219 Homo sapiens), SAGE tags according to CGAP, plus additional links to SOURCE, and/or GNF BioGPS, and/or EXPOLDB, and/or UniProtKB,
Expression Assays from Applied Biosystems )
About This Section

YARS expression in normal and diseased human tissues

Applied Biosystems TaqMan ® Gene Expression Assays for YARS

¹ / ² / ³

3 probe-sets matching YARS gene

Affymetrix probe-set	Array	# genes	Sensitivity	Specificity	Correlation	Length	Gb_Accession	Consensus	Uniqueness	Score	Rank
Affymetrix probe-set	Array	GeneAnnot data			GeneNote data		GeneTide data
38977_at²^{, 3}	U95-A	1	1.00	1.00	1.00	1.00	U89436	1.00	0.90	0.95	1
212048_s_at²^{, 3}	U133-A	1	1.00	1.00	--	--	AW245400	0.60	1.00	0.82	1
212048_s_at²	U133Plus2	1	1.00	1.00	--	--	--	--	--	--	--

About this table

Data from

(Publications) and GNF BioGPS
About these images
About these images

CGAP SAGE TAG: ACCAAGCTGG

SOURCE GeneReport for Unigene cluster: Hs.706890
Expression variation in blood from EXPOLDB for YARS

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD and/or ⁵MGI Jun 06 2009, with possible further links to Flybase and/or WormBase, Gene Trees according to Ensembl)
About This Section

Orthologs for YARS gene from 5/21 species (see all 21 )

Organism	Gene	Locus	Description	Human Similarity	NCBI accessions
dog (Canis familiaris)	YARS¹	--	tyrosyl-tRNA synthetase	91.91(n) 95.3(a)	478148 XM_535324.2 XP_535324.2
chimpanzee (Pan troglodytes)	YARS¹	--	tyrosyl-tRNA synthetase	99.68(n) 99.81(a)	469266 XM_524651.2 XP_524651.2
cow (Bos taurus)	YARS¹	--	tyrosyl-tRNA synthetase	91.35(n) 94.32(a)	281581 NM_174220.2 NP_776645.1
rat (Rattus norvegicus)	Yars¹	--	tyrosyl-tRNA synthetase	89.27(n) 95.08(a)	313047 NM_001025696.1 NP_001020867.1
mouse (Mus musculus)	Yars^{1, 5}	4⁵	tyrosyl-tRNA synthetase^{1, 5}	89.33(n)¹ 96.21(a)¹	107271¹ NM_134151.3¹ NP_598912.2¹ AA003398⁵ AK028785⁵ (see all 33)

About this table Species with no ortholog for YARS

ENSEMBL Gene Tree for YARS

(Paralogs according to ¹HomoloGene
and ²Ensembl, Pseudogenes according to ³Pseudogene.org)
About This Section

Paralogs for YARS gene

ENSG00000164022²

(According to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, and UniProtKB, Linkage Disequilibrium by HapMap, Genotyping Reagents from Applied Biosystems)
About This Section

10/217 NCBI SNPs in YARS are shown (see all 217 )
(Click for Applied Biosystems TaqMan ® Genotyping Assay) (see all 72)

AB	SNP ID	Valid	Chr 1 pos	Sequence	Recs	AA Chg	Type	More	Recs	Pop	Total sample	More
AB	Genomic Data				Transcription Data				Allele Frequencies
				--	--	--		--	--			--
	rs16866009^1,2	C,F,H	33013876(+)	`ATTTTT/CAAATG`	1	--	ut3¹		7	NA EU EA WA	534
	rs2128600^1,2	C,H	33044670(-)	`CTGCAG/TGTACT`	1	Q/H	mis¹ ese³		4	EU EA WA	414
--	rs11544326^1,2	H	33049135(-)	`CCCATG/TTCAAA`	1	M/I	mis¹ ese³		4	EU EA WA	404
	rs699005^1,2	A,C,F,H	33018389(+)	`TGTACC/GAGGCC`	1	L/L	syn¹ ese³		17	EA NA MN EU WA	1384
	rs881393^1,2	A,C,F,H,O	33029232(-)	`AGGAGC/GCTTAC`	1	--	int¹		14	EA NA EU WA	1004
	rs10753265^1,2	A,C,F,H	33036599(+)	`AGGGAA/GGGAGA`	1	--	int¹ trp³		8	EU EA WA	838
	rs6677618^1,2	A,C,F,H	33053704(+)	`tggaaC/Taaccc`	1	--	int¹		4	EU EA WA	418
--	rs10914621^1,2	A,C,F,H	33049667(+)	`caaagC/Tctccg`	1	--	int¹		8	EU EA WA	836
	rs785419^1,2	A,C,F,H	33041778(+)	`aagtcC/Tgagat`	1	--	int¹		4	MN EU EA	482
	rs1765223^1,2	A,C,F,H	33029471(-)	`ATATCG/TGCTTT`	1	--	int¹		4	EU EA WA	418

About this table

HapMap Linkage Disequilibrium images for YARS (up to first 250kb)

(in which this Gene is Involved, According to OMIM, UniProtKB, Novoseek, PharmGKB, Genatlas, GeneTests, Blood group antigen gene mutations by BGMUT, HGMD, GAD, HuGE Navigator, BCGD, and/or TGDB.)
About This Section

OMIM: 603623 disorders: 608323

UniProtKB/Swiss-Prot: SYYC_HUMAN, P54577

Defects in YARS are the cause of Charcot-Marie-Tooth disease dominant intermediate type C

(CMTDIC) [MIM:608323]. CMTDIC is a form of Charcot-Marie-Tooth disease characterized by clinical

and pathologic features intermediate between demyelinating and axonal peripheral neuropathies, and

motor median nerve conduction velocities ranging from 25 to 45 m/sec

1 Novoseek disease relationship for YARS gene

Disease	Score	Articles	PubMed IDs for Articles with Shared Sentences (# sentences)
charcot-marie-tooth disease	39.87	1	17545306 (1)

About this table

Human Gene Mutation Database: YARS

(Possibly Related Articles in Doctor's Guide)
About This Section

(in PubMed. Associations of this gene to articles via ¹Novoseek, ²HGNC, ³Entrez Gene, ⁴UniProtKB/Swiss-Prot, ⁵UniProtKB/TrEMBL, ⁶GAD, and/or ⁷PharmGKB)
About This Section

10/80 PubMed articles for YARS gene (see all 80 ):

Human tyrosyl-tRNA synthetase shares amino acid sequence homology with a putative cytokine. (PubMed id 9162081)^{1, 2, 3, 4} Kleeman T.A....First E.A. (1997)
Evidence that two present-day components needed for the genetic code appeared after nucleated cells separated from eubacteria. (PubMed id 8552597)^{2, 3, 4} Ribas de Pouplana L.... Schimmel P. (1996)
Crystal structure of a human aminoacyl-tRNA synthetase cytokine. (PubMed id 12427973)^{1, 3, 4} Yang X.-L.... Schimmel P. (2002)
Crystal structures that suggest late development of genetic code components for differentiating aromatic side chains. (PubMed id 14671330)^{1, 3, 4} Yang X.-L....Ribas de Pouplana L. (2003)
Disrupted function and axonal distribution of mutant tyrosyl-tRNA synthetase in dominant intermediate Charcot-Marie-Tooth neuropathy. (PubMed id 16429158)^{3, 4} Jordanova A....Timmerman V. (2006)
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)^{3, 4} Gerhard D.S....Malek J. (2004)
Exploring proteomes and analyzing protein processing by mass spectrometric identification of sorted N-terminal peptides. (PubMed id 12665801)^{3, 4} Gevaert K.... Vandekerckhove J. (2003)
Catalysis of tyrosyl-adenylate formation by the human tyrosyl-tRNA synthetase. (PubMed id 11856731)^{1, 3} Austin J. and First E.A. (2002)
Human mitochondrial TyrRS disobeys the tyrosine identity rules. (PubMed id 15840810)^{1, 3} Bonnefond L....Rudinger-Thirion J. (2005)
Highly differentiated motifs responsible for two cytokine activities of a split human tRNA synthetase. (PubMed id 10438485)^{1, 3} Wakasugi K. and Schimmel P. (1999)

(in PubMed, OMIM, and NCBI Bookshelf)
About This Section

		AND	OR
Aliases
Free Text

Query String		PubMed OMIM NCBI Bookshelf
	(Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, and/or H-InvDB)
About This Section

Entrez Gene: 8565	HGNC: 12840	AceView: YARS.1	Ensembl:ENSG00000134684	euGenes: HUgn8565
ECgene: YARS	H-InvDB: YARS

(According to HUGE)
About This Section

(According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section

Licensable Technologies for YARS
(Available from WIS Yeda, Salk, Tufts)

About This Section

(Reagents available from Applied Biosystems, Antibodies and assays by Cell Signaling Technology, Abcam, Novus Biologicals,
Sigma-Aldrich, R&D Systems, Millipore, Abnova, and/or Invitrogen, Clones available from OriGene,and/or Invitrogen, Drugs and/or compounds by Sigma-Aldrich,
Enzo Life Sciences, and/or Tocris Bioscience)
About This Section

Products for YARS:

TaqMan ® Gene Expression Assays

TaqMan ® Genotyping Assays

Free SNP selection tool

Invitrogen iPath Pathways	Invitrogen BLOCK-iT™ RNAi
Invitrogen Antibodies	Invitrogen Assays
Invitrogen Clones	Invitrogen Q-PCR Products
Invitrogen Human Recombinant Kinases	Invitrogen Custom Antibody and Peptide Service
Invitrogen Proteins / Assays / Screening Services	Search Invitrogen catalog for YARS-related products

	Millipore Custom Antibody & Bulk Services
	Millipore Preclinical / Clinical Development Services
	Millipore Immunoassay Services
	Millipore Target Screening & Profiling Services

	Predesigned and custom siRNAs for YARS		Antibodies for YARS
	Explore super-pooled esiRNAs		Browse proteins at Sigma-Aldrich
	Lentivirus-delivered shRNAs for YARS		Browse small molecules at Sigma-Aldrich
	"Your Favorite Gene" Pathways		feedback

	Antibodies		Primer Pairs
	Cell Culture Products		ELISAs
	Flow Cytometry Kits		Protease Activity Assays & Reagents
	Cell Selection/Detection Kits & Reagents		ELISA/Assay Development Kits & Reagents
	Multiplex/Array Assay Kits & Reagents		ELISpot Kits & Development Modules
	Recombinant & Natural Proteins

	Recombinant Proteins (YARS)
	Antibodies (YARS)
	Chimera RNAi (YARS)
	Custom Service for Mouse Mab
	Custom Service for Rabbit Pab from Full-length Protein

Search for Antibodies & Assays

	Recombinant Proteins (Tyrosyl tRNA synthetase)
	Antibodies (Tyrosyl tRNA synthetase)

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Search Tocris compounds for YARS

Search www.enzolifesicences.com for proteins, assays, substrates, inhibitors & antibodies

Antibodies for YARS

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YARS Gene

protein-coding GIFtS: 63

Aliases &
Descriptions
for YARS

Summaries
for YARS

Genomic Location
for YARS

Proteins
for YARS

Protein Domains/
Families
for YARS

Gene Function
for YARS

Pathways & Interactions
for YARS

Drugs & Compounds
for YARS

Transcripts
for YARS

Expression
for YARS

Orthologs
for YARS

Paralogs
for YARS

SNPs/Variants
for YARS

Disorders & Mutations
for YARS

Medical News
for YARS

Publications
for YARS

Search for YARS

Genome Databases showing YARS

Other Databases showing YARS

Specialized Databases showing YARS

Licensable Technologies
for YARS

Services
for YARS

Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

YARS Gene

protein-coding GIFtS: 63

Aliases & Descriptionsfor YARS

Summariesfor YARS

Genomic Locationfor YARS

Proteinsfor YARS

Protein Domains/Familiesfor YARS

Gene Functionfor YARS

Pathways & Interactionsfor YARS

Drugs & Compoundsfor YARS

Transcriptsfor YARS

Expression for YARS

Orthologsfor YARS

Paralogsfor YARS

SNPs/Variantsfor YARS

Disorders & Mutationsfor YARS

Medical Newsfor YARS

Publicationsfor YARS

Search for YARS

Genome Databases showing YARS

Other Databases showing YARS

Specialized Databases showing YARS

Licensable Technologiesfor YARS

Servicesfor YARS

Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

Aliases &
Descriptions
for YARS

Summaries
for YARS

Genomic Location
for YARS

Proteins
for YARS

Protein Domains/
Families
for YARS

Gene Function
for YARS

Pathways & Interactions
for YARS

Drugs & Compounds
for YARS

Transcripts
for YARS

Expression
for YARS

Orthologs
for YARS

Paralogs
for YARS

SNPs/Variants
for YARS

Disorders & Mutations
for YARS

Medical News
for YARS

Publications
for YARS

Licensable Technologies
for YARS

Services
for YARS