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YARS Gene

protein-coding   GIFtS: 69
GCID: GC01M033240

Tyrosyl-TRNA Synthetase

  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Tyrosyl-TRNA Synthetase1 2 3     Tyrosine TRNA Ligase 11
EC 6.1.1.13 8     Tyrosine TRNA Ligase 1, Cytoplasmic2
CMTDIC2 5     Tyrosine--TRNA Ligase, Cytoplasmic2
TYRRS2 5     Tyrosyl--TRNA Ligase2
YRS2 5     Tyrosyl-TRNA Synthetase, Cytoplasmic2
YTS2 5     TyrRS3
cytoplasmic1     EC 6.1.18

External Ids:    HGNC: 128401   Entrez Gene: 85652   Ensembl: ENSG000001346847   OMIM: 6036235   UniProtKB: P545773   

Export aliases for YARS gene to outside databases

Previous GC identifers: GC01M033060 GC01M032195 GC01M032667 GC01M032743 GC01M032909 GC01M033013 GC01M031356


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for YARS Gene:
Aminoacyl-tRNA synthetases catalyze the aminoacylation of tRNA by their cognate amino acid. Because of their
central role in linking amino acids with nucleotide triplets contained in tRNAs, aminoacyl-tRNA synthetases are
thought to be among the first proteins that appeared in evolution. Tyrosyl-tRNA synthetase belongs to the class I
tRNA synthetase family. Cytokine activities have also been observed for the human tyrosyl-tRNA synthetase, after
it is split into two parts, an N-terminal fragment that harbors the catalytic site and a C-terminal fragment
found only in the mammalian enzyme. The N-terminal fragment is an interleukin-8-like cytokine, whereas the
released C-terminal fragment is an EMAP II-like cytokine. (provided by RefSeq, Jul 2008)

GeneCards Summary for YARS Gene:
YARS (tyrosyl-tRNA synthetase) is a protein-coding gene. Diseases associated with YARS include intermediate charcot-marie-tooth neuropathy, and charcot-marie-tooth disease, dominant intermediate c. GO annotations related to this gene include tyrosine-tRNA ligase activity and signal transducer activity.

UniProtKB/Swiss-Prot: SYYC_HUMAN, P54577
Function: Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction: tyrosine is first activated by
ATP to form Tyr-AMP and then transferred to the acceptor end of tRNA(Tyr) (By similarity)

Gene Wiki entry for YARS Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence:
NC_000001.11  NC_018912.2  NT_032977.10  
Regulatory elements:
   Regulatory transcription factor binding sites in the YARS gene promoter:
         E2F-3a   E2F-4   E2F-5   E2F-1   E2F   E2F-2   NF-kappaB1   NF-kappaB   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 5): YARS promoter sequence
   Search Chromatin IP Primers for YARS

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat YARS


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 1p35.1   Ensembl cytogenetic band:  1p35.1   HGNC cytogenetic band: 1p35.1

YARS Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
YARS gene location

GeneLoc information about chromosome 1         GeneLoc Exon Structure

GeneLoc location for GC01M033240:  view genomic region     (about GC identifiers)

Start:
33,240,840 bp from pter      End:
33,283,754 bp from pter
Size:
42,915 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
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UniProtKB/Swiss-Prot: SYYC_HUMAN, P54577 (See protein sequence)
Recommended Name: Tyrosine--tRNA ligase, cytoplasmic  
Size: 528 amino acids; 59143 Da
Subunit: Homodimer
Sequence caution: Sequence=AAB39406.1; Type=Frameshift; Positions=354;
3 PDB 3D structures from and Proteopedia for YARS:
1N3L (3D)        1NTG (3D)        1Q11 (3D)    
Secondary accessions: B3KWK4 D3DPQ4 O43276 Q53EN1

Explore the universe of human proteins at neXtProt for YARS: NX_P54577

Explore proteomics data for YARS at MOPED

Post-translational modifications: 

  • Ubiquitination2 at Lys119, Lys147, Lys197, Lys206, Lys513
  • Modification sites at PhosphoSitePlus
  • Selected DME Specific Peptides for YARS (P54577) (see all 21)
     EKHPDAD  GVESQGM  SIGVPLE  KAMLESI 


    See YARS Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_003671.1  
    ENSEMBL proteins: 
     ENSP00000362576  
    Reactome Protein details: P54577

    YARS Human Recombinant Protein Products:

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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    aaRS1: Aminoacyl tRNA synthetases / Class I

    Selected InterPro protein domains (see all 6):
     IPR002307 Tyr-tRNA-ligase
     IPR023617 Tyr-tRNA-ligase_arc/euk-type
     IPR002305 aa-tRNA-synth_Ic
     IPR002547 tRNA-bd_dom
     IPR012340 NA-bd_OB-fold

    Graphical View of Domain Structure for InterPro Entry P54577

    ProtoNet protein and cluster: P54577

    3 Blocks protein domains:
    IPB002305 Aminoacyl-tRNA synthetase
    IPB002307 Tyrosyl-tRNA synthetase signature
    IPB002547 t-RNA-binding region


    UniProtKB/Swiss-Prot: SYYC_HUMAN, P54577
    Similarity: Belongs to the class-I aminoacyl-tRNA synthetase family
    Similarity: Contains 1 tRNA-binding domain


    YARS for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: SYYC_HUMAN, P54577
    Function: Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction: tyrosine is first activated by
    ATP to form Tyr-AMP and then transferred to the acceptor end of tRNA(Tyr) (By similarity)
    Catalytic activity: ATP + L-tyrosine + tRNA(Tyr) = AMP + diphosphate + L-tyrosyl-tRNA(Tyr)

         Enzyme Numbers (IUBMB): EC 6.1.1.11 2 EC 6.1.12

         Gene Ontology (GO): Selected molecular function terms (see all 8):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000049tRNA binding IEA--
    GO:0000166nucleotide binding ----
    GO:0004812aminoacyl-tRNA ligase activity ----
    GO:0004831tyrosine-tRNA ligase activity TAS--
    GO:0004871signal transducer activity NAS10102815
         
    YARS for ontologies           About GeneDecksing


    Phenotypes:
         1 GenomeRNAi human phenotype for YARS:
     Increased S DNA content 

         1 MGI phenotypic allele for Yars (no phenotypes)

    YARS for phenotypes           About GeneDecksing

    Animal Models:
       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for YARS
       inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for YARS

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for YARS
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for YARS

    miRNA
    Products:
        
    miRTarBase miRNAs that target YARS:
    hsa-mir-423-5p (MIRT038166), hsa-mir-186-5p (MIRT045031), hsa-mir-193b-3p (MIRT041463), hsa-mir-155-5p (MIRT020751), hsa-mir-877-3p (MIRT037152)

    Block miRNA regulation of human, mouse, rat YARS using miScript Target Protectors
    8 qRT-PCR Assays for microRNAs that regulate YARS:
    hsa-miR-379 hsa-miR-623 hsa-miR-607 hsa-miR-605 hsa-miR-3175 hsa-miR-211 hsa-miR-188-3p hsa-miR-204
    SwitchGear 3'UTR luciferase reporter plasmidYARS 3' UTR sequence
    Inhib. RNA
    Products:
        
    OriGene RNAi products in human, mouse, rat for YARS
    Predesigned siRNA for gene silencing in human, mouse, rat YARS

    Gene Editing
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    DNA2.0 Custom Protein Engineering Service for YARS

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    GenScript: all cDNA clones in your preferred vector: YARS (NM_003680)
    Sino Biological Human cDNA Clone for YARS
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for YARS
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat YARS

    Cell Line
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    Browse ESI BIO Cell Lines and PureStem Progenitors for YARS 
    In Situ Assay
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for YARS


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    SYYC_HUMAN, P54577: Cytoplasm
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    cytosol4
    extracellular4
    nucleus4
    mitochondrion1

    Gene Ontology (GO): 4 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005615extracellular space TAS10102815
    GO:0005634nucleus IDA--
    GO:0005737cytoplasm IDA--
    GO:0005829cytosol TAS--

    YARS for ontologies           About GeneDecksing


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for YARS About                                                                                                See pathways by source

    SuperPathContained pathways About
    1tRNA Aminoacylation
    tRNA Aminoacylation0.57
    Aminoacyl-tRNA biosynthesis0.52
    Cytosolic tRNA aminoacylation0.57
    2Gene Expression
    Gene Expression0.40
    3Tyrosine metabolism p.1 dopamine
    Tyrosine metabolism p.1 dopamine

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways


    1 GeneGo (Thomson Reuters) Pathway for YARS
        Tyrosine metabolism p.1 (dopamine)


    1 Reactome Pathway for YARS
        Cytosolic tRNA aminoacylation


    1 Kegg Pathway  (Kegg details for YARS):
        Aminoacyl-tRNA biosynthesis


    YARS for pathways           About GeneDecksing

        Pathway & Disease-focused RT2 Profiler PCR Array including YARS: 
              Inflammatory Response & Autoimmunity 384HT in human mouse rat

    Interactions:

        Search GeneGlobe Interaction Network for YARS

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for YARS (P545773 ENSP000003625764) via UniProtKB, MINT, STRING, and/or I2D (see all 169)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    CARSP495893, ENSP000003698974I2D: score=3 STRING: ENSP00000369897
    PROSCO949033, ENSP000003335514I2D: score=3 STRING: ENSP00000333551
    EIF1BO607393, ENSP000002329054I2D: score=2 STRING: ENSP00000232905
    SAP18O004223, ENSP000003719734I2D: score=2 STRING: ENSP00000371973
    GABARAPL2P605203, ENSP000000372434I2D: score=1 STRING: ENSP00000037243
    About this table

    Gene Ontology (GO): 5 biological process terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006418tRNA aminoacylation for protein translation TAS--
    GO:0006437tyrosyl-tRNA aminoacylation IEA--
    GO:0006915apoptotic process TAS10102815
    GO:0007165signal transduction NAS10102815
    GO:0010467gene expression TAS--

    YARS for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
    About This Section

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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for YARS (SYYC)

    5 HMDB Compounds for YARS    About this table
    CompoundSynonyms CAS #PubMed Ids
    Adenosine monophosphate5'-AMP (see all 28)61-19-8--
    Adenosine triphosphate5'-(tetrahydrogen triphosphate) Adenosine (see all 24)56-65-5--
    L-Tyrosine(-)-a-Amino-p-hydroxyhydrocinnamate (see all 28)60-18-4--
    Phosphoric acidacide phosphorique (FRENCH) (see all 20)7664-38-2--
    Pyrophosphate(4-)Diphosphoric acid ion (see all 10)14000-31-8--

    1 DrugBank Compound for YARS    About this table
    CompoundSynonyms CAS #TypeActionsPubMed Ids
    Tyrosinal-- --target--10592235

    10 Novoseek inferred chemical compound relationships for YARS gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    aminoacyl-trna 87.5 3 7743129 (1), 15779907 (1), 17401211 (1)
    trna(tyr) 84.4 4 10630994 (4)
    trna 73.6 45 9162081 (7), 7743129 (2), 18560823 (2), 12450387 (2) (see all 11)
    anticodon 52 3 15130561 (1), 12427973 (1)
    tyrosine 47.5 10 11856731 (4), 12016229 (2), 9057892 (1), 10630994 (1) (see all 6)
    hydrogen 19.7 1 18560823 (1)
    atp 16.4 7 12016229 (2), 18560823 (2), 7711024 (1), 12473451 (1)
    gtp 9.1 1 7530051 (1)
    lysine 2.82 1 12016229 (1)
    potassium 0 3 11856731 (2), 12016229 (1)



    YARS for compounds           About GeneDecksing



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
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    REFSEQ mRNAs for YARS gene: 
    NM_003680.3  

    Unigene Cluster for YARS:

    Tyrosyl-tRNA synthetase
    Hs.213264  [show with all ESTs]
    Unigene Representative Sequence: AK125213
    9 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000469100(uc001bvw.1) ENST00000373477(uc001bvy.1) ENST00000490826
    ENST00000487404(uc001bvx.1) ENST00000478828 ENST00000481895 ENST00000466052
    ENST00000470377 ENST00000472692
    miRNA
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    8 qRT-PCR Assays for microRNAs that regulate YARS:
    hsa-miR-379 hsa-miR-623 hsa-miR-607 hsa-miR-605 hsa-miR-3175 hsa-miR-211 hsa-miR-188-3p hsa-miR-204
    SwitchGear 3'UTR luciferase reporter plasmidYARS 3' UTR sequence
    Inhib. RNA
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    Clone
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    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: YARS (NM_003680)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for YARS
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat YARS
    Primer
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    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat YARS
      QuantiTect SYBR Green Assays in human, mouse, rat YARS
      QuantiFast Probe-based Assays in human, mouse, rat YARS

    Additional mRNA sequence: 

    AK026535.1 AK125213.1 AK223608.1 BC001933.1 BC004151.2 BC016689.1 U40714.1 U89436.1 

    Selected DOTS entries (see all 42):

    DT.40291549  DT.100877451  DT.95168272  DT.100877446  DT.95168270  DT.318916  DT.100877456  DT.100877466 
    DT.40121470  DT.431953  DT.121452224  DT.121452370  DT.121452219  DT.121452391  DT.95335382  DT.99986548 
    DT.100877447  DT.121452364  DT.70100695  DT.100044946  DT.121452312  DT.100877472  DT.101971391  DT.75132549 

    1 AceView cDNA sequence:

    AK127879 

    GeneLoc Exon Structure

    Selected Alternative Splicing Database (ASD) splice patterns (SP) for YARS (see all 6)    About this scheme

    ExUns: 1 ^ 2 ^ 3 ^ 4a · 4b ^ 5 ^ 6 ^ 7a · 7b ^ 8a · 8b · 8c ^ 9a · 9b · 9c ^ 10 ^ 11 ^ 12a · 12b ^ 13 ^ 14a · 14b
    SP1:        -                                   -                       -     -           -                 -                           
    SP2:                                                                                      -                                             
    SP3:                                                                                                                                    
    SP4:                                                                                                                                    
    SP5:                                                                    -     -                                                         


    ECgene alternative splicing isoforms for YARS

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

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    YARS expression in normal human tissues (normalized intensities)      YARS embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: ACCAAGCTGG
    YARS Expression
    About this image


    YARS expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 8) fully expand
     
     Brain (Nervous System)    fully expand to see all 6 entries
             Cerebral Cortex
     
     Ovary (Reproductive System)    fully expand to see all 2 entries
             Ovarian Mesenchymal Stroma Cells Ovary Interstitium
             Oviduct
     
     Neural Tube (Nervous System)    fully expand to see all 2 entries
             Metencephalon
     
     Bone (Muscoskeletal System)
             Bone Marrow
     
     Kidney (Urinary System)
             Metanephros
    YARS Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    YARS Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.213264
        Pathway & Disease-focused RT2 Profiler PCR Array including YARS: 
              Inflammatory Response & Autoimmunity 384HT in human mouse rat

    Primer
    Products:
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    QuantiFast Probe-based Assays in human, mouse, rat YARS
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for YARS

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of eukaryotes.

    Orthologs for YARS gene from Selected species (see all 25)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Yars1 , 5 tyrosyl-tRNA synthetase1, 5 89.52(n)1
    96.59(a)1
      4 (63.05 cM)5
    1072711  NM_134151.41  NP_598912.41 
     1291897605 
    chicken
    (Gallus gallus)
    Aves YARS1 tyrosyl-tRNA synthetase 78.12(n)
    87.29(a)
      419666  NM_001006314.1  NP_001006314.1 
    lizard
    (Anolis carolinensis)
    Reptilia YARS6
    tyrosyl-tRNA synthetase
    85(a)
    1 ↔ 1
    GL343711.1(184516-191344)
    African clawed frog
    (Xenopus laevis)
    Amphibia BC045236.12   -- 75.52(n)    BC045236.1 
    zebrafish
    (Danio rerio)
    Actinopterygii yars2 tyrosyl-tRNA synthetase 76.42(n)   368235  AY398430.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta CG45613
    Aats-tyr1
    tyrosine-tRNA ligase3
    Tyrosyl-tRNA synthetase1
    67(a)3
    65.61(n)1
    69.7(a)1
      72F13
    398291  NM_140638.31  NP_648895.11 
    worm
    (Caenorhabditis elegans)
    Secernentea Y105E8A.193   -- 68(a)   I(14488818-14494791)   --
    baker's yeast
    (Saccharomyces cerevisiae)
    Saccharomycetes TYS1(YGR185C)4
    TYS11
    Cytoplasmic tyrosyl-tRNA synthetase, required for cytoplasmic more4
    TYS11
    59.84(n)1
    58.48(a)1
      7(867520-866336)4
    8530971, 4  NP_011701.31  NP_011701.14 
    rice
    (Oryza sativa)
    Liliopsida Os04g03039001 Os04g0303900 53.73(n)
    45.9(a)
      4335424  NM_001058948.1  NP_001052413.1 


    ENSEMBL Gene Tree for YARS (if available)
    TreeFam Gene Tree for YARS (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section

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    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
    About This Section

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    Selected SNPs for YARS (see all 880)    About this table    
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 1 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    VAR_0266844
    Charcot-Marie-Tooth disease, dominant, intermediate type, C (CMTDIC)4--see VAR_0266842 E K mis40--------
    VAR_0266814
    Charcot-Marie-Tooth disease, dominant, intermediate type, C (CMTDIC)4--see VAR_0266812 G R mis40--------
    rs354319201,2
    C--33244017(+) TTTTTT/-GAGAC 1 -- int11Minor allele frequency- -:0.50NA 2
    rs2016443601,2
    C--33249609(+) TTTTT-/TGAGAC 1 -- int10--------
    rs1137265881,2
    C--33253428(+) TATTTC/TAACAT 1 -- int11Minor allele frequency- T:0.50CSA 2
    rs556811621,2
    C--33258157(+) ATTGC-/AATA  
            
    AATAG
    1 -- int10--------
    rs1133588431,2
    F--33260440(+) CATCTG/CTACTA 1 -- int11Minor allele frequency- C:0.50CSA 2
    rs2012075651,2
    --33261956(+) GTATT-/TATTTTT 1 -- int10--------
    rs770332531,2
    C--33261957(+) TATTT-/A/AT  
            
    TTTTT
    1 -- int10--------
    rs710063711,2
    C--33261973(-) CTCTGA/-AAAAA 1 -- int11Minor allele frequency- -:0.00NA 2

    HapMap Linkage Disequilibrium report for YARS (33240840 - 33283754 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 3 variations for YARS:    About this table    
    Variant IDTypeSubtypePubMed ID
    nsv509158CNV Insertion20534489
    nsv519188CNV Loss19592680
    nsv322CNV Loss18451855

    Human Gene Mutation Database (HGMD): YARS
    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing YARS
    DNA2.0 Custom Variant and Variant Library Synthesis for YARS

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 603623   
    OMIM disorders: 608323  
    UniProtKB/Swiss-Prot: SYYC_HUMAN, P54577
  • Charcot-Marie-Tooth disease, dominant, intermediate type, C (CMTDIC) [MIM:608323]: A form of
    Charcot-Marie-Tooth disease, a disorder of the peripheral nervous system, characterized by progressive weakness
    and atrophy, initially of the peroneal muscles and later of the distal muscles of the arms. The dominant
    intermediate type C is characterized by clinical and pathologic features intermediate between demyelinating and
    axonal peripheral neuropathies, and motor median nerve conduction velocities ranging from 25 to 45 m/sec.
    Note=The disease is caused by mutations affecting the gene represented in this entry

  • Selected diseases for YARS (see all 21):    About MalaCards
    intermediate charcot-marie-tooth neuropathy    charcot-marie-tooth disease, dominant intermediate c    yars-related intermediate charcot-marie-tooth neuropathy    primary cutaneous amyloidosis
    tooth disease    charcot-marie-tooth disease    amyloidosis    neuropathy
    peripheral neuropathy    pneumonia    tonsillitis    tuberculosis
    melanoma    endotheliitis    hiv-1    cerebritis
    multiple myeloma    thyroiditis    myeloma    malaria

    1 disease from the University of Copenhagen DISEASES database for YARS:
    Primary cutaneous amyloidosis

    YARS for disorders           About GeneDecksing

    1 Novoseek inferred disease relationship for YARS gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    charcot-marie-tooth disease 48.7 1 17545306 (1)


    Export disorders for YARS gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for YARS gene, integrated from 10 sources (see all 111):
    (articles sorted by number of sources associating them with YARS)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Human tyrosyl-tRNA synthetase shares amino acid sequence homology with a putative cytokine. (PubMed id 9162081)1, 2, 3, 9 Kleeman T.A.... First E.A. (J. Biol. Chem. 1997)
    2. Evidence that two present-day components needed for the genetic code appeared after nucleated cells separated from eubacteria. (PubMed id 8552597)1, 2, 3 Ribas de Pouplana L.... Schimmel P. (Proc. Natl. Acad. Sci. U.S.A. 1996)
    3. Crystal structure of a human aminoacyl-tRNA synthetase cytokine. (PubMed id 12427973)1, 2, 9 Yang X.-L.... Schimmel P. (Proc. Natl. Acad. Sci. U.S.A. 2002)
    4. Crystal structures that suggest late development of genetic code components for differentiating aromatic side chains. (PubMed id 14671330)1, 2, 9 Yang X.-L....Ribas de Pouplana L. (Proc. Natl. Acad. Sci. U.S.A. 2003)
    5. Disrupted function and axonal distribution of mutant tyrosyl-tRNA synthetase in dominant intermediate Charcot-Marie-Tooth neuropathy. (PubMed id 16429158)1, 2 Jordanova A....Timmerman V. (Nat. Genet. 2006)
    6. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (Nat. Genet. 2004)
    7. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    8. Exploring proteomes and analyzing protein processing by mass spectrometric identification of sorted N-terminal peptides. (PubMed id 12665801)1, 2 Gevaert K.... Vandekerckhove J. (Nat. Biotechnol. 2003)
    9. Catalysis of tyrosyl-adenylate formation by the human tyrosyl-tRNA synthetase. (PubMed id 11856731)1, 9 Austin J. and First E.A. (J. Biol. Chem. 2002)
    10. Dominant mutations in the tyrosyl-tRNA synthetase gene recapitulate in Drosophila features of human Charcot-Marie-Tooth neuropathy. (PubMed id 19561293)1, 9 Storkebaum E....Jordanova A. (Proc. Natl. Acad. Sci. U.S.A. 2009)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section

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    Entrez Gene: 8565 HGNC: 12840 AceView: YARS.1 Ensembl:ENSG00000134684 euGenes: HUgn8565
    ECgene: YARS Kegg: 8565 H-InvDB: YARS

    (According to HUGE)
    About This Section

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    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
    About This Section

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    NameDescription
    PharmGKB entry for YARS Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section

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    Patent Information for YARS gene:
    Search GeneIP for patents involving YARS

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript, and ESI BIO, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
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