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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

YARS Gene

protein-coding   GIFtS: 66
GCID: GC01M033240

tyrosyl-tRNA synthetase
 Explore 13 diseases affiliated with
YARS via
MalaCards
our new
 Human Malady Compendium 
Biological research products
for YARS    

Aliases
for YARS gene

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, and/or 10fRNAdb)
About This Section
Aliases
Tyrosyl-TRNA Synthetase1 2 3     Tyrosine TRNA Ligase 1, Cytoplasmic2
YRS1 2 5     Tyrosine--TRNA Ligase, Cytoplasmic2
YTS1 2 5     Tyrosyl--TRNA Ligase2
EC 6.1.1.13 8     Tyrosyl-TRNA Synthetase, Cytoplasmic2
CMTDIC2 5     TyrRS3
TYRRS2 5     EC 6.1.18
TyrRS3     

External Ids:    HGNC: 128401   Entrez Gene: 85652   Ensembl: ENSG000001346847   OMIM: 6036235   UniProtKB: P545773   

Export aliases for YARS gene to outside databases

Previous GC identifers: GC01M033060 GC01M032195 GC01M032667 GC01M032743 GC01M032909 GC01M033013 GC01M031356


Summaries
for YARS gene

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section
Entrez Gene summary for YARS:
Aminoacyl-tRNA synthetases catalyze the aminoacylation of tRNA by their cognate amino acid. Because of their central
role in linking amino acids with nucleotide triplets contained in tRNAs, aminoacyl-tRNA synthetases are thought to be
among the first proteins that appeared in evolution. Tyrosyl-tRNA synthetase belongs to the class I tRNA synthetase
family. Cytokine activities have also been observed for the human tyrosyl-tRNA synthetase, after it is split into two
parts, an N-terminal fragment that harbors the catalytic site and a C-terminal fragment found only in the mammalian
enzyme. The N-terminal fragment is an interleukin-8-like cytokine, whereas the released C-terminal fragment is an EMAP
II-like cytokine. (provided by RefSeq, Jul 2008)

UniProtKB/Swiss-Prot: SYYC_HUMAN, P54577
Function: Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction: tyrosine is first activated by ATP
to form Tyr-AMP and then transferred to the acceptor end of tRNA(Tyr) (By similarity)

Gene Wiki entry for YARS


Genomic Views
for YARS gene

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000001.10  NC_018912.1  NT_032977.9  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the YARS gene promoter:
         E2F-3a   E2F-4   E2F-5   E2F-1   E2F   E2F-2   NF-kappaB1   NF-kappaB   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 5): YARS promoter sequence
   Search SABiosciences Chromatin IP Primers for YARS

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat YARS


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 1p35.1   Ensembl cytogenetic band:  1p35.1   HGNC cytogenetic band: 1p35.1

YARS Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
YARS gene location

GeneLoc information about chromosome 1         GeneLoc Exon Structure

GeneLoc location for GC01M033240:  view genomic region     (about GC identifiers)

Start:
 33,240,840 bp from pter      End:
 33,283,754 bp from pter
Size:
 42,915 bases      Orientation:
 minus strand

Proteins
for YARS gene

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section
UniProtKB/Swiss-Prot: SYYC_HUMAN, P54577 (See protein sequence)
Recommended Name: Tyrosine--tRNA ligase, cytoplasmic  
Size: 528 amino acids; 59143 Da
Subunit: Homodimer
Subcellular location: Cytoplasm
Sequence caution: Sequence=AAB39406.1; Type=Frameshift; Positions=354;
3 PDB 3D structures from and Proteopedia for YARS:
1N3L (3D)        1NTG (3D)        1Q11 (3D)    
Secondary accessions: B3KWK4 D3DPQ4 O43276 Q53EN1

Explore the universe of human proteins at neXtProt for YARS: NX_P54577

Post-translational modifications:

  • View modification sites using PhosphoSitePlus2
  • View neXtProt modification sites for NX_P54577

    • 4/21 DME Specific Peptides for YARS (P54577) (see all 21)
     EKHPDAD  GVESQGM  SIGVPLE  KAMLESI 

    YARS Protein expression data from MOPED and PaxDb:    About this image 
    Estimated protein expression log10 (pmol).

    REFSEQ proteins: NP_003671.1  
    ENSEMBL proteins: 
     ENSP00000362576  
    Reactome Protein details: P54577
    Human Recombinant Protein Products: 
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    Novus Biologicals YARS Proteins
    Novus Biologicals YARS Lysate
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    ProSpec Recombinant Protein for YARS
    Uscn Proteins for YARS

    Gene Ontology (GO): 5 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005615extracellular space TAS10102815
    GO:0005625soluble fraction ----
    GO:0005634nucleus IDA--
    GO:0005737cytoplasm IDA--
    GO:0005829cytosol TAS--


    YARS for ontologies           About GeneDecksing



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    Uscn ELISAs and CLIAs for YARS

    Protein Domains /
    Families
    for YARS gene

    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    YARS for domains           About GeneDecksing

    5/6 InterPro domains/families (see all 6):
     IPR012340 NA-bd_OB-fold
     IPR002307 Tyr-tRNA-ligase
     IPR014729 Rossmann-like_a/b/a_fold
     IPR023617 Tyr-tRNA-ligase_arc/euk-type
     IPR002305 aa-tRNA-synth_Ic

    Graphical View of Domain Structure for InterPro Entry P54577

    ProtoNet protein and cluster: P54577

    3 Blocks protein families:
    IPB002305 Aminoacyl-tRNA synthetase
    IPB002307 Tyrosyl-tRNA synthetase signature
    IPB002547 t-RNA-binding region


    UniProtKB/Swiss-Prot: SYYC_HUMAN, P54577
    Similarity: Belongs to the class-I aminoacyl-tRNA synthetase family
    Similarity: Contains 1 tRNA-binding domain


    Function
    for YARS gene

    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
    About This Section
    Function Summary:

         UniProtKB/Swiss-Prot: SYYC_HUMAN, P54577
    Function: Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction: tyrosine is first activated by ATP
    to form Tyr-AMP and then transferred to the acceptor end of tRNA(Tyr) (By similarity)
    Catalytic activity: ATP + L-tyrosine + tRNA(Tyr) = AMP + diphosphate + L-tyrosyl-tRNA(Tyr)

    Enzyme Numbers (IUBMB): EC 6.1.1.11 2 EC 6.1.12

    miRNA
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    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat YARS
    8 QIAGEN miScript miRNA Assays for microRNAs that regulate YARS:
    hsa-miR-379 hsa-miR-623 hsa-miR-607 hsa-miR-605 hsa-miR-3175 hsa-miR-211 hsa-miR-188-3p hsa-miR-204
    SwitchGear 3'UTR luciferase reporter plasmid: YARS 3' UTR sequence
    Inhib. RNA
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    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for YARS (see all 7)
    OriGene shRNA RFP: YARS
    OriGene siRNA: YARS
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat YARS

    Gene Editing
    Products:    		DNA2.0 Custom Protein Engineering Service for YARS

    Clone
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    OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for YARS (see all 3)
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    Search LifeMap BioReagents cell lines for YARS

    In Situ Assay
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    Gene Ontology (GO): 5 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000049tRNA binding IEA--
    GO:0004831tyrosine-tRNA ligase activity TAS--
    GO:0004871signal transducer activity NAS10102815
    GO:0005153interleukin-8 receptor binding TAS10102815
    GO:0005524ATP binding IEA--


    YARS for ontologies           About GeneDecksing


    1 GenomeRNAi human phenotype for YARS:
     Increased S DNA content 


    Pathways & Interactions
    for YARS gene

    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
    About This Section

    Unified GeneCards pathways  About this table 
    See pathways by source

    Super-pathwaycontained gene-specific pathways
    1tRNA Aminoacylation
    		tRNA Aminoacylation1.00
    		Aminoacyl-tRNA biosynthesis0.54
    		Cytosolic tRNA aminoacylation0.57
    2Tyrosine metabolism
    		Tyrosine metabolism p.1 (dopamine) 0.28
    		Tyrosine metabolism p.1 (dopamine)0.28
    3Generic Transcription Pathway
    		Gene Expression0.46

    Pathway sources
    See GeneCards unified pathways
    Show all pathways

    1 EMD Millipore Pathway for YARS
        Tyrosine metabolism p.1 (dopamine)


    1 GeneGo (Thomson Reuters) Pathway for YARS
        Tyrosine metabolism p.1 (dopamine)

    3        Reactome Pathways for YARS
        Cytosolic tRNA aminoacylation
    tRNA Aminoacylation
    Gene Expression


    1         Kegg Pathway  (Kegg details for YARS):
        Aminoacyl-tRNA biosynthesis


    YARS for pathways           About GeneDecksing

    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for YARS

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    5/70 Interacting proteins for YARS (P545773 ENSP000003625764) via UniProtKB, MINT, STRING, and/or I2D (see all 70)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    PROSCO949033, ENSP000003335514I2D: score=3 STRING: ENSP00000333551
    RPL4P365783, ENSP000003114304I2D: score=2 STRING: ENSP00000311430
    SAP18O004223, ENSP000003719734I2D: score=2 STRING: ENSP00000371973
    GABARAPL2P605203, ENSP000000372434I2D: score=1 STRING: ENSP00000037243
    GNB2L1P632443, ENSP000003660134I2D: score=1 STRING: ENSP00000366013
    About this table

    Gene Ontology (GO): 5 biological process terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006418tRNA aminoacylation for protein translation TAS--
    GO:0006437tyrosyl-tRNA aminoacylation IEA--
    GO:0006915apoptotic process TAS10102815
    GO:0007165signal transduction NAS10102815
    GO:0010467gene expression TAS--


    YARS for ontologies           About GeneDecksing



    Drugs & Compounds
    for YARS gene

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section

    YARS for compounds           About GeneDecksing

    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for YARS

    5 HMDB Compounds for YARS    About this table
    CompoundSynonyms CAS #PubMed Ids
    Adenosine monophosphate5'-AMP (see all 28)61-19-8--
    Adenosine triphosphate5'-(tetrahydrogen triphosphate) Adenosine (see all 24)56-65-5--
    L-Tyrosine(-)-a-Amino-p-hydroxyhydrocinnamate (see all 28)60-18-4--
    Phosphoric acidacide phosphorique (FRENCH) (see all 20)7664-38-2--
    Pyrophosphate(4-)Diphosphoric acid ion (see all 10)14000-31-8--

    1 DrugBank Compound for YARS    About this table
    CompoundSynonyms CAS #TypeActionsPubMed Ids
    Tyrosinal-- --target--10592235

    10 Novoseek chemical compound relationships for YARS gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    aminoacyl-trna 87.5 3 7743129 (1), 15779907 (1), 17401211 (1)
    trna(tyr) 84.4 4 10630994 (4)
    trna 73.6 45 9162081 (7), 7743129 (2), 18560823 (2), 12450387 (2) (see all 11)
    anticodon 52 3 15130561 (1), 12427973 (1)
    tyrosine 47.5 10 11856731 (4), 12016229 (2), 9057892 (1), 10630994 (1) (see all 6)
    hydrogen 19.7 1 18560823 (1)
    atp 16.4 7 12016229 (2), 18560823 (2), 7711024 (1), 12473451 (1)
    gtp 9.1 1 7530051 (1)
    lysine 2.82 1 12016229 (1)
    potassium 0 3 11856731 (2), 12016229 (1)

    Search CenterWatch for drugs/clinical trials and news about YARS / SYYC 

    Transcripts
    for YARS gene

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section
    REFSEQ mRNAs for YARS gene: 
    NM_003680.3  

    Unigene Cluster for YARS:

    Tyrosyl-tRNA synthetase
    Hs.213264  [show with all ESTs]
    Unigene Representative Sequence: AK125213
    9 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000469100(uc001bvw.1) ENST00000373477(uc001bvy.1) ENST00000490826
    ENST00000487404(uc001bvx.1) ENST00000478828 ENST00000481895 ENST00000466052
    ENST00000470377 ENST00000472692

    miRNA
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    8 QIAGEN miScript miRNA Assays for microRNAs that regulate YARS:
    hsa-miR-379 hsa-miR-623 hsa-miR-607 hsa-miR-605 hsa-miR-3175 hsa-miR-211 hsa-miR-188-3p hsa-miR-204
    SwitchGear 3'UTR luciferase reporter plasmid: YARS 3' UTR sequence
    Inhib. RNA
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    Clone
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    Primer
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    Additional cDNA sequence: 

    AK026535.1 AK125213.1 AK223608.1 BC001933.1 BC004151.2 BC016689.1 U40714.1 U89436.1 

    24/42 DOTS entries (see all 42):

    DT.40291549  DT.100877451  DT.95168272  DT.100877446  DT.95168270  DT.318916  DT.100877456  DT.100877466 
    DT.40121470  DT.431953  DT.121452224  DT.121452370  DT.121452219  DT.121452391  DT.95335382  DT.99986548 
    DT.100877447  DT.121452364  DT.70100695  DT.100044946  DT.121452312  DT.100877472  DT.101971391  DT.75132549 

    1 AceView cDNA sequence:

    AK127879 

    GeneLoc Exon Structure

    5/6 Alternative Splicing Database (ASD) splice patterns (SP) for YARS (see all 6)    About this scheme

    ExUns: 1 ^ 2 ^ 3 ^ 4a · 4b ^ 5 ^ 6 ^ 7a · 7b ^ 8a · 8b · 8c ^ 9a · 9b · 9c ^ 10 ^ 11 ^ 12a · 12b ^ 13 ^ 14a · 14b
    SP1:        -                                   -                       -     -           -                 -                           
    SP2:                                                                                      -                                             
    SP3:                                                                                                                                    
    SP4:                                                                                                                                    
    SP5:                                                                    -     -                                                         


    ECgene alternative splicing isoforms for YARS

    Expression
    for YARS gene

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    YARS expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS
    CGAP TAG: ACCAAGCTGG

    Microarray
    RNAseq (Illumina Body Map)
    (100×FPKM)½
    SAGE (Serial Analysis of Gene Expression)
    About this image

    YARS expression in embryonic tissues and stem cells
    Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine    About this table
    Stem Cell Differentiation: 1 LifeMap Cell 
    NameCategory
    Definitive endoderm-like cells (A scalable, suspensi...)
    Expression: Positive    Negative     Selective marker
    Experimental details: Curated     Microarrays     In-situ hybridization

    See YARS Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for YARS

    SOURCE GeneReport for Unigene cluster: Hs.213264
        SABiosciences Expression via Pathway-Focused PCR Array including YARS: 
              Inflammatory Response & Autoimmunity 384HT in human mouse rat

    Primer
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    In Situ
    Assay Products:     
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    Orthologs
    for YARS gene

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section
    This gene was present in the common ancestor of eukaryotes.

    Orthologs for YARS gene from 10/38 species (see all 38)    About this table
    Organism Taxonomic
    classification    		 Gene Description Human
    Similarity    		 Orthology
    Type    		 Details
    mouse
    (Mus musculus)    		 Mammalia Yars1 , 5 tyrosyl-tRNA synthetase1, 5 89.52(n)1
    96.59(a)1    		   4 (63.05 cM)5
    1072711  NM_134151.41  NP_598912.31 
     1291897605 
    chicken
    (Gallus gallus)    		 Aves YARS1 tyrosyl-tRNA synthetase 78.12(n)
    87.29(a)    		   419666  NM_001006314.1  NP_001006314.1 
    lizard
    (Anolis carolinensis)    		 Reptilia YARS6
    		 --
    		 85(a)
    		 1 ↔ 1
    		 GL343711.1(184549-191344)
    African clawed frog
    (Xenopus laevis)    		 Amphibia BC045236.12   -- 75.52(n)    BC045236.1 
    zebrafish
    (Danio rerio)    		 Actinopterygii yars2 tyrosyl-tRNA synthetase 76.42(n)   368235  AY398430.1 
    fruit fly
    (Drosophila melanogaster)    		 Insecta CG45613
    Aats-tyr1    		 tyrosine-tRNA ligase3
    Tyrosyl-tRNA synthetase1    		 67(a)3
    65.61(n)1
    69.7(a)1    		   72F13
    398291  NM_140638.21  NP_648895.11 
    worm
    (Caenorhabditis elegans)    		 Secernentea Y105E8A.193   -- 68(a)   I(14488818-14494791)   --
    baker's yeast
    (Saccharomyces cerevisiae)    		 Saccharomycetes TYS1(YGR185C)4
    TYS11    		 Cytoplasmic tyrosyl-tRNA synthetase, required for cytoplasmic more4
    Tys1p1    		 59.16(n)1
    57.55(a)1    		   7(867520-866336)4
    8530971, 4  NP_011701.31  NP_011701.14 
    thale cress
    (Arabidopsis thaliana)    		 eudicotyledons AT1G283506
    AT2G338406
    		 tyrosyl-tRNA synthetase
    		 9(a)
    19(a)
    		 possible ortholog
    possible ortholog
    		 1(9944036-9949800)
    2(14314944-14317499)
    rice
    (Oryza sativa)    		 Liliopsida --
    --
    (see all 4)    		 tRNA synthetase, putative, expressed
    (see all 4)    		 19(a)
    19(a)
    (see all 4)    		 possible ortholog
    possible ortholog
    (see all 4)    		 8(13917211-13923003)
    8(2923196-2927516)


    ENSEMBL Gene Tree for YARS (if available)
    TreeFam Gene Tree for YARS (if available) 

    Paralogs
    for YARS gene

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    		  --

    Genomic Variants
    for YARS gene

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/714 NCBI SNPs in YARS are shown (see all 714)     About this table
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance    		Chr 1 posSequence#AA
    Chg    		TypeMore#Allele
    freq    		PopTotal
    sample    		More
    ----------
    rs1135525411,2
    		--31386419(+) GAGGGA/GGAGAG 1 -- int11Minor allele frequency- G:0.00CSA 1
    rs74111741,2
    		H--33240416(+) CCATAA/GAATGT 4 -- ds5001 ut315Minor allele frequency- G:0.00NS EA NA 414
    rs1846876611,2
    		--33240521(+) ACACAC/TGAAGA 4 -- ds5001 ut310--------
    rs109146111,2
    		C,F,A,H,--33240596(+) AATGTG/TGGGGG 4 -- int1 ds500116Minor allele frequency- T:0.14NS EA NA 2114
    rs773725581,2
    		C--33240613(+) GCAGTA/GGTCTG 4 -- ds5001 int10--------
    rs779223461,2
    		C--33240615(+) AGTGGC/TCTGGG 4 -- int1 ds50010--------
    rs1890048031,2
    		--33240661(+) ACACAC/TTGGAC 4 -- ds5001 int10--------
    rs2005739031,2
    		--33240733(+) TTCTA-/CCCCCC 4 -- ds5001 int10--------
    rs1813598311,2
    		--33240740(+) CCCCAC/GCCCCC 4 -- ds5001 int10--------
    rs783190351,2
    		C,F,--33240901(+) GCCTTA/CTGGAG 4 -- ds5001 int1 ut311Minor allele frequency- C:0.05WA 118

    HapMap Linkage Disequilibrium report for YARS (33240840 - 33283754 bp)
    Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
          Database of Genomic Variants (DGV) variations for YARS: --
    Human Gene Mutation Database (HGMD): YARS

    SABiosciences Cancer Mutation PCR Assays
    QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing YARS
    DNA2.0 Custom Variant and Variant Library Synthesis for YARS

    Disorders / Diseases
    for YARS gene

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    YARS for disorders           About GeneDecksing

    OMIM gene information: 603623   
    OMIM disorders: 608323  
    UniProtKB/Swiss-Prot: SYYC_HUMAN, P54577
  • Defects in YARS are the cause of Charcot-Marie-Tooth disease dominant intermediate type C (CMTDIC)
    • [MIM:608323]. CMTDIC is a form of Charcot-Marie-Tooth disease characterized by clinical and pathologic features
    intermediate between demyelinating and axonal peripheral neuropathies, and motor median nerve conduction velocities
    ranging from 25 to 45 m/sec

    13 diseases for YARS:    About MalaCards
    charcot-marie-tooth disease, dominant intermediate c    charcot-marie-tooth disease    charcot-marie-tooth neuropathy    tooth disease
    primary cutaneous amyloidosis    peripheral neuropathy    neuropathy    amyloidosis
    pneumonia    tuberculosis    melanoma    intermediate charcot-marie-tooth neuropathy
    mycobacterium tuberculosis

    1 disease from the University of Copenhagen DISEASES database for YARS:
    Primary cutaneous amyloidosis

    1 Novoseek disease relationship for YARS gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    charcot-marie-tooth disease 48.7 1 17545306 (1)


    Export disorders for YARS gene to outside databases

    Publications
    for YARS gene

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for YARS gene, integrated from 9 sources (see all 104):
    (articles sorted by number of sources associating them with YARS)    		    Utopia: connect your pdf to the dynamic
    world of online information

    1. Human tyrosyl-tRNA synthetase shares amino acid sequence homology with a putative cytokine. (PubMed id 9162081)1, 2, 3, 9 Kleeman T.A.... First E.A. (1997)
    2. Evidence that two present-day components needed for the genetic code appeared after nucleated cells separated from eubacteria. (PubMed id 8552597)1, 2, 3 Ribas de Pouplana L.... Schimmel P. (1996)
    3. Crystal structure of a human aminoacyl-tRNA synthetase cytokine. (PubMed id 12427973)1, 2, 9 Yang X.-L.... Schimmel P. (2002)
    4. Crystal structures that suggest late development of genetic code components for differentiating aromatic side chains. (PubMed id 14671330)1, 2, 9 Yang X.-L....Ribas de Pouplana L. (2003)
    5. Disrupted function and axonal distribution of mutant tyrosyl-tRNA synthetase in dominant intermediate Charcot-Marie-Tooth neuropathy. (PubMed id 16429158)1, 2 Jordanova A....Timmerman V. (2006)
    6. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
    7. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    8. Exploring proteomes and analyzing protein processing by mass spectrometric identification of sorted N-terminal peptides. (PubMed id 12665801)1, 2 Gevaert K.... Vandekerckhove J. (2003)
    9. Catalysis of tyrosyl-adenylate formation by the human tyrosyl-tRNA synthetase. (PubMed id 11856731)1, 9 Austin J. and First E.A. (2002)
    10. Dominant mutations in the tyrosyl-tRNA synthetase gen e recapitulate in Drosophila features of human Charcot-Marie-Tooth neuropathy. (PubMed id 19561293)1, 9 Storkebaum E....Jordanova A. (2009)

    External Searches for YARS gene

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Disorders
    Free Text  
      Query String
    		PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    Genome Databases showing YARS gene

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 8565 HGNC: 12840 AceView: YARS.1 Ensembl:ENSG00000134684 euGenes: HUgn8565
    ECgene: YARS Kegg: 8565 H-InvDB: YARS

    Other Databases showing YARS gene

    (According to HUGE)
    About This Section
    		   --

    Specialized Databases showing YARS gene

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for YARS Pharmacogenomics, SNPs, Pathways

    Intellectual Property
    for YARS gene

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    		Patent Information for YARS gene:
    Search GeneIP for patents involving YARS

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    Products
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    About This Section

     
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    GeneCards Homepage - Last full update: 19 Mar 2013 - Incrementals: 21 Mar 2013 , 15 Apr 2013 , 26 Apr 2013

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