Aliases for YARS Gene
External Ids for YARS Gene
Previous GeneCards Identifiers for YARS Gene
Aminoacyl-tRNA synthetases catalyze the aminoacylation of tRNA by their cognate amino acid. Because of their central role in linking amino acids with nucleotide triplets contained in tRNAs, aminoacyl-tRNA synthetases are thought to be among the first proteins that appeared in evolution. Tyrosyl-tRNA synthetase belongs to the class I tRNA synthetase family. Cytokine activities have also been observed for the human tyrosyl-tRNA synthetase, after it is split into two parts, an N-terminal fragment that harbors the catalytic site and a C-terminal fragment found only in the mammalian enzyme. The N-terminal fragment is an interleukin-8-like cytokine, whereas the released C-terminal fragment is an EMAP II-like cytokine. [provided by RefSeq, Jul 2008]
GeneCards Summary for YARS Gene
YARS (Tyrosyl-TRNA Synthetase) is a Protein Coding gene. Diseases associated with YARS include Charcot-Marie-Tooth Disease, Dominant Intermediate C and Intermediate Charcot-Marie-Tooth Neuropathy. Among its related pathways are Tyrosine metabolism and tRNA Aminoacylation. GO annotations related to this gene include poly(A) RNA binding and signal transducer activity.
UniProtKB/Swiss-Prot for YARS Gene
Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction: tyrosine is first activated by ATP to form Tyr-AMP and then transferred to the acceptor end of tRNA(Tyr).