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YARS Gene

protein-coding   GIFtS: 63

GC01M033013
tyrosyl-tRNA synthetase
Symbol approved by the HUGO Gene Nomenclature Committee (HGNC) database
Services    
(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc , and/or 7Ensembl, 8miRBase)
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Aliases
CMTDIC 2, 5
EC 6.1.1.1 3
OTTHUMP00000004027 2
TYRRS 2, 5
TyrRS 3
YRS 1, 2, 5
YTS 1, 2, 5
tyrRS 1
Descriptions
Tyrosyl--tRNA ligase 3
tyrosine tRNA ligase 1, cytoplasmic 2
tyrosyl-tRNA synthetase 2
External Ids
HGNC: 128401
Entrez Gene: 85652
UniProtKB: P545773
Ensembl: ENSG000001346847
Search outside databases for aliases for YARS gene

Previous GC identifers: GC01M033060 GC01M032195 GC01M032667 GC01M032743 GC01M032909

(According to Entrez Gene, Wikipedia's Gene Wiki,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

EntrezGene summary for YARS:
Aminoacyl-tRNA synthetases catalyze the aminoacylation of tRNA by their cognate amino acid. Because
of their central role in linking amino acids with nucleotide triplets contained in tRNAs,
aminoacyl-tRNA synthetases are thought to be among the first proteins that appeared in evolution.
Tyrosyl-tRNA synthetase belongs to the class I tRNA synthetase family. Cytokine activities have
also been observed for the human tyrosyl-tRNA synthetase, after it is split into two parts, an
N-terminal fragment that harbors the catalytic site and a C-terminal fragment found only in the
mammalian enzyme. The N-terminal fragment is an interleukin-8-like cytokine, whereas the released
C-terminal fragment is an EMAP II-like cytokine. [provided by RefSeq]

UniProtKB/Swiss-Prot: SYYC_HUMAN, P54577
Function: Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction: tyrosine is
first activated by ATP to form Tyr-AMP and then transferred to the acceptor end of tRNA(Tyr) (By
similarity)

Gene Wiki entry for YARS

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 36),
and/or miRBase,
Genomic Views according to UCSC and Ensembl, Transcription factor binding sites according to SABiosciences)
About This Section

Genomic View:
UCSC Golden Path with GeneCards custom track

 Transcription factor binding sites upstream to the YARS gene  

Entrez Gene cytogenetic band: 1p35.1   Ensembl cytogenetic band:  1p35.1   HGNC cytogenetic band: 1p35.1

YARS Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)

GeneLoc gene densities for chromosome 1         GeneLoc Exon Structure

GeneLoc location for GC01M033013:     (about GC identifiers)

Start:
33,013,427 bp from pter
End:
33,056,220 bp from pter
Size:
42,794 bases
Orientation:
minus strand
RefSeq DNA sequence:
NC_000001.9  NT_032977.8  
(According to 1UniProtKB, and/or Ensembl, Phosphorylation sites according to 2Phosphosite, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Enzo Life Sciences, Abnova, OriGene and/or, Abcam,
Biochemical Assays by Invitrogen, Millipore, R&D Systems, Cell Signaling Technology, and/or Enzo Life Sciences, Ontologies according to Gene Ontology Consortium 01 Apr 2009 and Entrez Gene, Antibodies by Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Cell Signaling Technology, Abcam, Abnova, and/or Novus Biologicals)
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UniProtKB/Swiss-Prot: SYYC_HUMAN, P54577 (See protein sequence)
Recommended Name: Tyrosyl-tRNA synthetase, cytoplasmic  
Size: 528 amino acids; 59143 Da
Subunit: Homodimer
Subcellular location: Cytoplasm
Sequence caution: Sequence=AAB39406.1; Type=Frameshift; Positions=354;
PDB structures from and Proteopedia :
1N3L (3D)    1NTG (3D)    1Q11 (3D)    
Secondary accessions: O43276 Q53EN1

Post-translational modifications:

  • View phosphorylation sites using PhosphoSite2


  • REFSEQ proteins: NP_003671.1  

    ENSEMBL proteins: 
    ENSP00000362576 


    Human Recombinant Proteins 
    Browse Drug Discovery Central at Invitrogen for human recombinant proteins
    Browse Purified and Recombinant Proteins at Millipore
    Browse Human Recombinant Proteins at Sigma-Aldrich  
    Browse R&D Systems for human recombinant proteins
    Browse recombinant and purified proteins available from Enzo Life Sciences
    Recombinant Proteins from Abcam (Tyrosyl tRNA synthetase)
    Human Recombinant Proteins from Abnova (YARS)
                    Browse Origene for full length recombinant human proteins expressed in human HEK293 cells 

    3 Gene Ontology (GO) cellular component terms (links to tree view):

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005615 extracellular space TAS10102815
    GO:0005625 soluble fraction TAS9162081
    GO:0005737 cytoplasm TAS9162081
    About this table

    Antibodies for YARS: 
    Browse Antibodies Central at Invitrogen
    Browse Millipore's Extensive Line of Mono- and Polyclonal Antibodies
    Sigma-Aldrich Antibodies for YARS
    Browse R&D Systems for Antibodies
    Antibodies from Abcam (Tyrosyl tRNA synthetase), each with their AbpromiseSM
    Monoclonal and Polyclonal Antibodies from Abnova (YARS)
    Novus Biologicals Antibodies for YARS

    Assays for YARS: 
    Browse Invitrogen for biochemical assays
    Browse Kits and Assays available from Millipore
    Browse R&D Systems for biochemical assays
    Browse biochemical assays available from Enzo Life Sciences

    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section

    5/7 InterPro domains/families (see all 7 ):
     IPR002307 Tyr-tRNA-synth_Ib_bac/mito
     IPR015624 Tyr-tRNA-synth_Ib_arc/euk
     IPR002305 aa-tRNA-synth_Ib
     IPR002547 tRNA_bd
     IPR001412 aa-tRNA-synth_I_CS


       GeneDecks  YARS for the domains selected above  
    About GeneDecksing

    Graphical View of Domain Structure for InterPro Entry P54577

    ProtoNet protein and cluster: P54577

    3 Blocks protein families:
    IPB002305 Aminoacyl-tRNA synthetase
    IPB002307 Tyrosyl-tRNA synthetase signature
    IPB002547 t-RNA-binding region


    UniProtKB/Swiss-Prot: SYYC_HUMAN, P54577
    Similarity: Belongs to the class-I aminoacyl-tRNA synthetase family
    Similarity: Contains 1 tRNA-binding domain

    (According to MGI Jun 06 2009, UniProtKB, IUBMB,and/or Genatlas,
    shRNA from OriGene, Sigma-Aldrich, RNAi from Sigma-Aldrich,
    RNAi Products, Clones, and Q-PCR Products from Invitrogen, Millipore, OriGene, and/or Abnova, siRNAs from Applied Biosystems, SYBR primers from OriGene, Cell-based Assays from Millipore, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
    About This Section

    Inhib.
    RNA:
    Invitrogen RNAi Products for gene knock-down (YARS)
    Browse for Gene Knock-down Tools from Millipore
    Abnova Chimera RNAi Products for Gene knock-down (YARS)
                  OriGene 29mer shRNA kit in GFP-retroviral vector: NM_003680

                  Applied Biosystems Silencer® siRNAs for YARS

                  Sigma-Aldrich siRNA for YARS  
                         Sigma-Aldrich shRNA for YARS  
                         Explore Sigma-Aldrich super-pooled esiRNAs  

    Clones:Browse Clone Ranger at Invitrogen for clones
    Browse Clones for the Expression of Recombinant Proteins Available from Millipore
                  OriGene GFP tagged cDNA clone in CMV expression vector: NM_003680
                                     Myc/DDK tagged cDNA clone in CMV expression vector: NM_003680
                                     untagged cDNA clones in CMV expression vector (see all 2): NM_003680 

    Primers: Browse Quantitative PCR Central at Invitrogen for Q-PCR LUX™ Primers
                  OriGene genome-wide validated SYBR primer pairs: NM_003680

    UniProtKB/Swiss-Prot: SYYC_HUMAN, P54577
    Function: Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction: tyrosine is
    first activated by ATP to form Tyr-AMP and then transferred to the acceptor end of tRNA(Tyr) (By
    similarity)
    Catalytic activity: ATP + L-tyrosine + tRNA(Tyr) = AMP + diphosphate + L-tyrosyl-tRNA(Tyr)
    Enzyme Number (IUBMB): EC 6.1.1.1 

    5/8 Gene Ontology (GO) molecular function terms (links to tree view) (see all 8 ):

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000049 tRNA binding IEA--
    GO:0000166 nucleotide binding IEA--
    GO:0004831 tyrosine-tRNA ligase activity TAS9162081
    GO:0004871 signal transducer activity NAS10102815
    GO:0005153 interleukin-8 receptor binding TAS10102815
    About this table

    (Pathways according to Invitrogen (maps by GeneGo), Millipore, Cell Signaling Technology, Sigma-Aldrich, KEGG and/or UniProtKB,
    Sets of similar genes according to GeneDecks, Proteins Network according to SABiosciences, Interactions according to 1UniProtKB, 2MINT, and/or 3STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
    About This Section


    1 Millipore Pathway for YARS
     Tyrosine metabolism p.1 (dopamine)

       GeneDecks  YARS for the pathways selected above  
    About GeneDecksing

    2 Sigma-Aldrich "Your Favorite Gene" Pathways for  YARS  (Your Favorite Gene powered by Ingenuity) 
     Phenylalanine, Tyrosine and Tryptophan Biosynthesis
     Aminoacyl-tRNA Biosynthesis

       GeneDecks  YARS for the pathways selected above  
    About GeneDecksing

    2 Kegg Pathways  (Kegg details for YARS):
     hsa00400 Phenylalanine, tyrosine and tryptophan biosynthesis
     hsa00970 Aminoacyl-tRNA biosynthesis

       GeneDecks  YARS for the pathways selected above  
    About GeneDecksing

    5/25 Interacting proteins for YARS (P545771 ENSP000003625763) via UniProtKB, MINT, and/or STRING (see all 25 )
    InteractantInteraction Details
    GeneCardExternal ID(s)
    ARF6P623301EBI-1048893, EBI-638181
    EIF1BO607391EBI-1048893, EBI-1043343
    EIF6P565371EBI-1048893, EBI-372243
    SAP18O004221EBI-1048893, EBI-1044156
    YARS2ENSP000003206583STRING (score=.978)
    About this table

    2 Gene Ontology (GO) biological process terms (links to tree view):

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006437 tyrosyl-tRNA aminoacylation TAS9162081
    GO:0006915 apoptosis TAS10102815
    About this table
    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, Sigma-Aldrich, Tocris Bioscience, and/or Novoseek and Drugs according to Enzo Life Sciences and/or PharmGKB)
    About This Section

    Browse drugs & compounds from Enzo Life Sciences
    Browse Small Molecules at Sigma-Aldrich

    Browse Tocris compounds for YARS
    10 Novoseek chemical compound relationships for YARS gene
    Compound   Score   Articles   PubMed IDs for Articles with Shared Sentences (# sentences)
    aminoacyl-trna 87.18 3 7743129 (1), 15779907 (1), 17401211 (1)
    trna(tyr) 84.91 4 10630994 (4)
    trna 74.67 45 9162081 (7), 7743129 (2), 18560823 (2), 12450387 (2) (see all 11)
    anticodon 53.41 3 15130561 (1), 12427973 (1)
    tyrosine 49.18 10 11856731 (4), 12016229 (2), 9057892 (1), 10630994 (1) (see all 6)
    hydrogen 22.38 1 18560823 (1)
    atp 18.39 7 12016229 (2), 18560823 (2), 7711024 (1), 12473451 (1)
    gtp 10.82 1 7530051 (1)
    lysine 5.02 1 12016229 (1)
    potassium 0.00 3 11856731 (2), 12016229 (1)
    About this table


    (GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 219 Homo sapiens; Jun 2 2009) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView,
    non coding RNAs according to RNAdb,
    ESTs according to GeneTide,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from Invitrogen, Millipore, and/or Abnova,
    siRNAs from Applied Biosystems, Sigma-Aldrich,
    shRNA from Sigma-Aldrich, OriGene,
    Tagged/untagged cDNA clones from OriGene,
    Expression Assays from Applied Biosystems)
    About This Section

    Inhib.
    RNA:
    Invitrogen RNAi Products for gene knock-down (YARS)
    Browse for Gene Knock-down Tools from Millipore
    Abnova Chimera RNAi Products for Gene knock-down (YARS)
                  OriGene 29mer shRNA kit in GFP-retroviral vector: NM_003680

                  Sigma-Aldrich siRNA for YARS  
                         Sigma-Aldrich shRNA for YARS  
                         Explore Sigma-Aldrich super-pooled esiRNAs  

    Applied Biosystems Silencer® siRNAs: 

    NM_003680  

    REFSEQ mRNAs for YARS gene: 

    NM_003680.3   

    Applied Biosystems TaqMan ® Gene Expression Assays: 

    NM_003680  

                  OriGene GFP tagged cDNA clone in CMV expression vector: NM_003680
                                     Myc/DDK tagged cDNA clone in CMV expression vector: NM_003680
                                     untagged cDNA clones in CMV expression vector (see all 2): NM_003680 

    Additional cDNA sequence: 

    AK026535.1 AK125213.1 AK223608.1 BC001933.1 BC004151.2 BC016689.1 CR622576.1 CR626320.1 
    U40714.1 U89436.1 

    24/42 DOTS entries (see all 42 ):

    DT.40291549  DT.100877451  DT.95168272  DT.100877446  DT.95168270  DT.318916  DT.100877456  DT.100877466 
    DT.40121470  DT.431953  DT.121452224  DT.121452370  DT.121452219  DT.121452391  DT.95335382  DT.99986548 
    DT.100877447  DT.121452364  DT.70100695  DT.100044946  DT.121452312  DT.100877472  DT.101971391  DT.75132549 

    1 AceView cDNA sequence:

    AK127879 

    highest scoring ESTs for YARS:

    U89436 AA307563 AU077088 AW249253 BE256528 BE294655 BF102544 BI227347 BM560131 BQ360410 

    Unigene Cluster for YARS:

    Tyrosyl-tRNA synthetase
    Hs.706890  [show with all ESTs]
    Unigene Representative Sequence: AK125213


    GeneLoc Exon Structure

    5/6 Alternative Splicing Database (ASD) splice patterns (SP) for YARS (see all 6 )

    ExUns: 1 ^ 2 ^ 3 ^ 4a · 4b ^ 5 ^ 6 ^ 7a · 7b ^ 8a · 8b · 8c ^ 9a · 9b · 9c ^ 10 ^ 11 ^ 12a · 12b ^ 13 ^ 14a · 14b
    SP1:        -                                   -                       -     -           -                 -                           
    SP2:                                                                                      -                                             
    SP3:                                                                                                                                    
    SP4:                                                                                                                                    
    SP5:                                                                    -     -                                                         

    About this scheme

    ECgene alternative splicing isoforms for YARS

    1 Ensembl transcript including schematic representation:
    ENST00000373477  
    (Experimental results according to 1GeneNote and GNF BioGPS,
    probe sets-to-genes annotations according to 2GeneAnnot , 3GeneTide , Sets of similar genes according to GeneDecks, Electronic Northern calculations according to data from UniGene (Build 219 Homo sapiens), SAGE tags according to CGAP, plus additional links to SOURCE, and/or GNF BioGPS, and/or EXPOLDB, and/or UniProtKB,
    Expression Assays from Applied Biosystems )
    About This Section

    YARS expression in normal and diseased human tissues

     Applied Biosystems TaqMan ® Gene Expression Assays for YARS

    1 / 2 / 3

    3 probe-sets matching YARS gene


    Affymetrix
    probe-set
    Array  GeneAnnot data GeneNote data GeneTide data
    # genes Sensitivity Specificity Correlation Length Gb_Accession Consensus Uniqueness Score Rank

    38977_at2, 3 U95-A 1 1.00 1.00 1.00 1.00 U89436 1.00 0.90 0.95 1

    212048_s_at2, 3 U133-A 1 1.00 1.00 -- -- AW245400 0.60 1.00 0.82 1

    212048_s_at2 U133Plus2 1 1.00 1.00 -- -- -- -- -- -- --
    About this table
    Data from (Publications) and GNF BioGPS
        About these images
    About these images

    CGAP SAGE TAG: ACCAAGCTGG

    SOURCE GeneReport for Unigene cluster: Hs.706890

    Expression variation in blood from EXPOLDB for YARS

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD and/or 5MGI Jun 06 2009, with possible further links to Flybase and/or WormBase, Gene Trees according to Ensembl)
    About This Section


    Orthologs for YARS gene from 5/21 species (see all 21 )
    Organism Gene Locus Description Human
    Similarity
    NCBI accessions
    dog
    (Canis familiaris)
    YARS1   -- tyrosyl-tRNA synthetase 91.91(n)
    95.3(a)
    478148  XM_535324.2  XP_535324.2 
    chimpanzee
    (Pan troglodytes)
    YARS1   -- tyrosyl-tRNA synthetase 99.68(n)
    99.81(a)
    469266  XM_524651.2  XP_524651.2 
    cow
    (Bos taurus)
    YARS1   -- tyrosyl-tRNA synthetase 91.35(n)
    94.32(a)
    281581  NM_174220.2  NP_776645.1 
    rat
    (Rattus norvegicus)
    Yars1   -- tyrosyl-tRNA synthetase 89.27(n)
    95.08(a)
    313047  NM_001025696.1  NP_001020867.1 
    mouse
    (Mus musculus)
    Yars1, 5 45
    tyrosyl-tRNA synthetase1, 5 89.33(n)1
    96.21(a)1
    1072711  NM_134151.31  NP_598912.21 
     AA0033985  AK0287855  (see all 33)
    About this table        Species with no ortholog for YARS

    ENSEMBL Gene Tree for YARS
    (Paralogs according to 1HomoloGene
    and 2Ensembl, Pseudogenes according to 3Pseudogene.org)
    About This Section

    Paralogs for YARS gene
    ENSG000001640222  

    (According to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, and UniProtKB, Linkage Disequilibrium by HapMap, Genotyping Reagents from Applied Biosystems)
    About This Section


    10/217 NCBI SNPs in YARS are shown (see all 217 )
    (Click for Applied Biosystems TaqMan ® Genotyping Assay)  (see all 72)
    ABGenomic DataTranscription DataAllele Frequencies
    SNP IDValidChr 1 posSequenceRecsAA
    Chg
    TypeMoreRecsAllele
    freq
    PopTotal
    sample
    More
    ------------
    rs168660091,2
    C,F,H33013876(+) ATTTTT/CAAATG 1 -- ut317Minor allele frequency- C:0.04NA EU EA WA 534
    rs21286001,2
    C,H33044670(-) CTGCAG/TGTACT 1 Q/H mis1 ese34Minor allele frequency- T:0.00EU EA WA 414
    --
    rs115443261,2
    H33049135(-) CCCATG/TTCAAA 1 M/I mis1 ese34Minor allele frequency- T:0.00EU EA WA 404
    rs6990051,2
    A,C,F,H33018389(+) TGTACC/GAGGCC 1 L/L syn1 ese317Minor allele frequency- G:0.14EA NA MN EU WA 1384
    rs8813931,2
    A,C,F,H,O33029232(-) AGGAGC/GCTTAC 1 -- int114Minor allele frequency- G:0.14EA NA EU WA 1004
    rs107532651,2
    A,C,F,H33036599(+) AGGGAA/GGGAGA 1 -- int1 trp38Minor allele frequency- G:0.40EU EA WA 838
    rs66776181,2
    A,C,F,H33053704(+) tggaaC/Taaccc 1 -- int14Minor allele frequency- T:0.30EU EA WA 418
    --
    rs109146211,2
    A,C,F,H33049667(+) caaagC/Tctccg 1 -- int18Minor allele frequency- T:0.12EU EA WA 836
    rs7854191,2
    A,C,F,H33041778(+) aagtcC/Tgagat 1 -- int14Minor allele frequency- T:0.13MN EU EA 482
    rs17652231,2
    A,C,F,H33029471(-) ATATCG/TGCTTT 1 -- int14Minor allele frequency- T:0.28EU EA WA 418
    About this table

    HapMap Linkage Disequilibrium images for YARS (up to first 250kb)

    (in which this Gene is Involved, According to OMIM, UniProtKB, Novoseek, PharmGKB, Genatlas, GeneTests, Blood group antigen gene mutations by BGMUT, HGMD, GAD, HuGE Navigator, BCGD, and/or TGDB.)
    About This Section

    OMIM: 603623   disorders: 608323  

    UniProtKB/Swiss-Prot: SYYC_HUMAN, P54577

  • Defects in YARS are the cause of Charcot-Marie-Tooth disease dominant intermediate type C
    (CMTDIC) [MIM:608323]. CMTDIC is a form of Charcot-Marie-Tooth disease characterized by clinical
    and pathologic features intermediate between demyelinating and axonal peripheral neuropathies, and
    motor median nerve conduction velocities ranging from 25 to 45 m/sec
  • 1 Novoseek disease relationship for YARS gene

    Disease   Score   Articles   PubMed IDs for Articles with Shared Sentences (# sentences)
    charcot-marie-tooth disease 39.87 1 17545306 (1)
    About this table

    Human Gene Mutation Database: YARS

    (Possibly Related Articles in Doctor's Guide)
    About This Section

      --

    (in PubMed. Associations of this gene to articles via 1Novoseek, 2HGNC, 3Entrez Gene, 4UniProtKB/Swiss-Prot, 5UniProtKB/TrEMBL, 6GAD, and/or 7PharmGKB)
    About This Section

    10/80 PubMed articles for YARS gene (see all 80 ):
    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section

     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)
    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, and/or H-InvDB)
    About This Section

    Entrez Gene: 8565 HGNC: 12840 AceView: YARS.1 Ensembl:ENSG00000134684 euGenes: HUgn8565
    ECgene: YARS H-InvDB: YARS
    (According to HUGE)
    About This Section

      --
    (According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section

      --
    (Available from WIS Yeda, Salk, Tufts)
    About This Section

      --
    (Reagents available from Applied Biosystems, Antibodies and assays by Cell Signaling Technology, Abcam, Novus Biologicals,
    Sigma-Aldrich, R&D Systems, Millipore, Abnova, and/or Invitrogen, Clones available from OriGene,and/or Invitrogen, Drugs and/or compounds by Sigma-Aldrich,
    Enzo Life Sciences, and/or Tocris Bioscience)
    About This Section



    Products for YARS:
     TaqMan ® Gene Expression Assays
     TaqMan ® Genotyping Assays
      Free SNP selection tool



      Invitrogen iPath Pathways  Invitrogen BLOCK-iT™ RNAi
      Invitrogen Antibodies  Invitrogen Assays
      Invitrogen Clones  Invitrogen Q-PCR Products
      Invitrogen Human Recombinant Kinases  Invitrogen Custom Antibody and Peptide Service
      Invitrogen Proteins / Assays / Screening Services  Search Invitrogen catalog for YARS-related products

     Millipore Custom Antibody & Bulk Services
     Millipore Preclinical / Clinical Development Services
     Millipore Immunoassay Services
     Millipore Target Screening & Profiling Services


     Predesigned and custom siRNAs for YARS Antibodies for YARS
     Explore super-pooled esiRNAs Browse proteins at Sigma-Aldrich
     Lentivirus-delivered shRNAs for YARS Browse small molecules at Sigma-Aldrich
     "Your Favorite Gene" Pathwaysfeedback


      
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     Search for Antibodies & Assays

     Recombinant Proteins
    (Tyrosyl tRNA synthetase)
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     Search Tocris compounds for YARS




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     Antibodies for YARS

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