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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

YAP1 Gene

protein-coding   GIFtS: 66
GCID: GC11P102015

Yes-Associated Protein 1

(Previous names: Yes-associated protein 1, 65kDa)
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(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Yes-Associated Protein 11 2     YAP22
65 KDa Yes-Associated Protein2 3     YKI2
YAP652 3     Yes-Associated Protein 22
Yes-Associated Protein 1, 65kDa1     Yorkie Homolog2
YAP2     

External Ids:    HGNC: 162621   Entrez Gene: 104132   Ensembl: ENSG000001376937   OMIM: 6066085   UniProtKB: P469373   

Export aliases for YAP1 gene to outside databases

Previous GC identifers: GC11P104175 GC11P103338 GC11P101519 GC11P101486 GC11P097907


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for YAP1 Gene:
This gene encodes a downstream nuclear effector of the Hippo signaling pathway which is involved in development,
growth, repair, and homeostasis. This gene is known to play a role in the development and progression of multiple
cancers as a transcriptional regulator of this signaling pathway and may function as a potential target for
cancer treatment. Alternative splicing results in multiple transcript variants encoding different isoforms.
(provided by RefSeq, Aug 2013)

GeneCards Summary for YAP1 Gene: 
YAP1 (Yes-associated protein 1) is a protein-coding gene. Diseases associated with YAP1 include japanese spotted fever, and spotted fever, and among its related super-pathways are Gene Expression and PIP3 activates AKT signaling. GO annotations related to this gene include chromatin binding and transcription corepressor activity. An important paralog of this gene is WWTR1.

UniProtKB/Swiss-Prot: YAP1_HUMAN, P46937
Function: Transcriptional regulator which can act both as a coactivator and a corepressor and is the critical
downstream regulatory target in the Hippo signaling pathway that plays a pivotal role in organ size control and
tumor suppression by restricting proliferation and promoting apoptosis. The core of this pathway is composed of a
kinase cascade wherein STK3/MST2 and STK4/MST1, in complex with its regulatory protein SAV1, phosphorylates and
activates LATS1/2 in complex with its regulatory protein MOB1, which in turn phosphorylates and inactivates YAP1
oncoprotein and WWTR1/TAZ. Plays a key role to control cell proliferation in response to cell contact.
Phosphorylation of YAP1 by LATS1/2 inhibits its translocation into the nucleus to regulate cellular genes
important for cell proliferation, cell death, and cell migration. The presence of TEAD transcription factors are
required for it to stimulate gene expression, cell growth, anchorage-independent growth, and epithelial
mesenchymal transition (EMT) induction. Isoform 2 and isoform 3 can activate the C-terminal fragment (CTF) of
ERBB4 (isoform 3)

Gene Wiki entry for YAP1 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000011.9  NT_033899.8  NC_018922.2  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the YAP1 gene promoter:
         TBP   p53   AP-1   p300   ATF-2   JunD   TFIID   c-Jun   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidYAP1 promoter sequence
   Search SABiosciences Chromatin IP Primers for YAP1

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat YAP1


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 11q13   Ensembl cytogenetic band:  11q22.1   HGNC cytogenetic band: 11q13

YAP1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
YAP1 gene location

GeneLoc information about chromosome 11         GeneLoc Exon Structure

GeneLoc location for GC11P102015:  view genomic region     (about GC identifiers)

Start:
101,981,192 bp from pter      End:
102,104,154 bp from pter
Size:
122,963 bases      Orientation:
plus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: YAP1_HUMAN, P46937 (See protein sequence)
Recommended Name: Yorkie homolog  
Size: 504 amino acids; 54462 Da
Subunit: Binds to the SH3 domain of the YES kinase. Binds to WBP1 and WBP2. Binds, in vitro, through the WW1
domain, to neural isoforms of ENAH that contain the PPSY motif (By similarity). The phosphorylated form interacts
with YWHAB. Interacts (via WW domains) with LATS1 (via PPxY motif 2). Interacts with LATS2. Isoform 2 and isoform
3 interact (via WW domain 1) with isoform 3 of ERBB4 (via PPxY motif 2). Interacts with TEAD1, TEAD2, TEAD3 and
TEAD4. Interacts with TP73. Interacts with RUNX1. Interacts with HCK. Interacts (via WW domains) with PTPN14 (via
PPxY motif 2); this interaction leads to the cytoplasmic sequestration of YAP1 and inhibits its transcriptional
coactivator activity
Subcellular location: Cytoplasm. Nucleus. Note=Both phosphorylation and cell density can regulate its subcellular
localization. Phosphorylation sequesters it in the cytoplasm by inhibiting its translocation into the nucleus. At
low density, predominantly nuclear and is translocated to the cytoplasm at high density. PTPN14 induces
translocation from the nucleus to the cytoplasm
6/11 PDB 3D structures from and Proteopedia for YAP1 (see all 11):
1JMQ (3D)        1K5R (3D)        1K9Q (3D)        1K9R (3D)        2LAW (3D)        2LAX (3D)    
Secondary accessions: B4DTY1 Q7Z574 Q8IUY9
Alternative splicing: 4 isoforms:  P46937-1   P46937-2   P46937-3   P46937-4   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for YAP1: NX_P46937

Explore proteomics data for YAP1 at MOPED 

Post-translational modifications:

  • UniProtKB: Phosphorylated by LATS1 and LATS2; leading to cytoplasmic translocation and inactivation. Phosphorylated by ABL1;
    leading to YAP1 stabilization, enhanced interaction with TP73 and recruitment onto proapoptotic genes; in
    response to DNA damage. Phosphorylation at Ser-400 and Ser-403 by CK1 is triggered by previous phosphorylation at
    Ser-397 by LATS proteins and leads to YAP1 ubiquitination by SCF(beta-TRCP) E3 ubiquitin ligase and subsequent
    degradation. Phosphorylated at Thr-119, Ser-138, Thr-154, Ser-367 and Thr-412 by MAPK8/JNK1 and MAPK9/JNK2, which
    is required for the regukation of apoptosis by YAP1
  • UniProtKB: Ubiquitinated by SCF(beta-TRCP) E3 ubiquitin ligase
  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_P46937

  • YAP1 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    YAP1 Protein Expression
    REFSEQ proteins (9 alternative transcripts): 
    NP_001123617.1  NP_001181973.1  NP_001181974.1  NP_001269026.1  NP_001269027.1  NP_001269028.1  NP_001269029.1  NP_001269030.1  
    NP_006097.2  

    ENSEMBL proteins: 
     ENSP00000434134   ENSP00000282441   ENSP00000431574   ENSP00000435602   ENSP00000431626  
     ENSP00000445635   ENSP00000331023  
    Reactome Protein details: P46937
    Human Recombinant Protein Products for YAP1: 
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    OriGene Protein Over-expression Lysate for YAP1
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    Novus Biologicals YAP1 Proteins
    Novus Biologicals YAP1 Lysates
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates 
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for YAP1 

    Gene Ontology (GO): 5 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus IDA17974916
    GO:0005654nucleoplasm TAS--
    GO:0005667transcription factor complex IEA--
    GO:0005737cytoplasm IDA17974916
    GO:0005829cytosol TAS--

    YAP1 for ontologies           About GeneDecksing



    YAP1 Antibody Products: 
    EMD Millipore Mono- and Polyclonal Antibodies for the study of YAP1
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    Abcam antibodies for YAP1
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    LSBio Antibodies in human, mouse, rat for YAP1 

    Assay Products for YAP1: 
    Browse Kits and Assays available from EMD Millipore
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    GenScript Custom Assay Services for YAP1
    Browse Enzo Life Sciences for kits & assays
    Cloud-Clone Corp. ELISAs for YAP1 
    Cloud-Clone Corp. CLIAs for YAP1


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    1 InterPro protein domain:
     IPR001202 WW_dom

    Graphical View of Domain Structure for InterPro Entry P46937

    ProtoNet protein and cluster: P46937

    1 Blocks protein domain: IPB002349 WW domain signature

    UniProtKB/Swiss-Prot: YAP1_HUMAN, P46937
    Similarity: Belongs to the YORKIE family
    Similarity: Contains 2 WW domains


    YAP1 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: YAP1_HUMAN, P46937
    Function: Transcriptional regulator which can act both as a coactivator and a corepressor and is the critical
    downstream regulatory target in the Hippo signaling pathway that plays a pivotal role in organ size control and
    tumor suppression by restricting proliferation and promoting apoptosis. The core of this pathway is composed of a
    kinase cascade wherein STK3/MST2 and STK4/MST1, in complex with its regulatory protein SAV1, phosphorylates and
    activates LATS1/2 in complex with its regulatory protein MOB1, which in turn phosphorylates and inactivates YAP1
    oncoprotein and WWTR1/TAZ. Plays a key role to control cell proliferation in response to cell contact.
    Phosphorylation of YAP1 by LATS1/2 inhibits its translocation into the nucleus to regulate cellular genes
    important for cell proliferation, cell death, and cell migration. The presence of TEAD transcription factors are
    required for it to stimulate gene expression, cell growth, anchorage-independent growth, and epithelial
    mesenchymal transition (EMT) induction. Isoform 2 and isoform 3 can activate the C-terminal fragment (CTF) of
    ERBB4 (isoform 3)

         Gene Ontology (GO): 5/7 molecular function terms (GO ID links to tree view) (see all 7):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0001076RNA polymerase II transcription factor binding transcription factor activity IEA--
    GO:0003682chromatin binding IEA--
    GO:0003713transcription coactivator activity IDA18158288
    GO:0003714transcription corepressor activity IDA18158288
    GO:0005515protein binding IPI11278422
         
    YAP1 for ontologies           About GeneDecksing


    Phenotypes:
         4 GenomeRNAi human phenotypes for YAP1:
     Decreased NANOG protein expres  Decreased OCT4 protein express  Decreased POU5F1-GFP protein e  Decreased viability of wild-ty 

         14 MGI mutant phenotypes (inferred from 7 alleles(MGI details for Yap1):
     cardiovascular system  cellular  digestive/alimentary  embryogenesis  endocrine/exocrine gland 
     growth/size  homeostasis/metabolism  immune system  integument  liver/biliary system 
     mortality/aging  nervous system  renal/urinary system  tumorigenesis 

    YAP1 for phenotypes           About GeneDecksing

    Animal Models:
         MGI mouse knock-outs for YAP1: Yap1tm1Smil Yap1tm1.2Dupa

       inGenious Targeting Laboratory - Custom generated mouse model solutions for YAP1 
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       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for YAP1 
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for YAP1 

    miRNA
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    miRTarBase miRNAs that target YAP1:
    hsa-mir-630 (MIRT005580), hsa-let-7b (MIRT005047)

    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat YAP1
    8/27 QIAGEN miScript miRNA Assays for microRNAs that regulate YAP1 (see all 27):
    hsa-miR-411* hsa-miR-3130-5p hsa-miR-379* hsa-miR-199b-3p hsa-miR-199a-3p hsa-miR-3942-5p hsa-miR-15a hsa-miR-200a
    Browse SwitchGear 3'UTR luciferase reporter plasmids
    Inhib. RNA
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    Gene Editing
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    Clone
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    GenScript: all cDNA clones in your preferred vector (see all 2): YAP1 (NM_001117)
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for YAP1


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section

    SuperPaths for YAP1 About   (see all 17)                                                                                              See pathways by source

    SuperPathContained pathways About
    1Generic Transcription Pathway
    Gene Expression0.47
    Generic Transcription Pathway0.47
    2PIP3 activates AKT signaling
    Signaling by ERBB40.67
    3Akt Signaling
    Akt Signaling0.60
    4Nanog in Mammalian ESC Pluripotency
    14-3-3 Induced Intracellular Signaling0.59
    5Signaling by GPCR
    Signal Transduction0.55

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    3 Downloadable PowerPoint Slides of QIAGEN Pathway Central Maps for YAP1
        14-3-3 and Regulation of BAD Activity
    14-3-3 Induced Intracellular Signaling
    Akt Signaling

    3 Cell Signaling Technology (CST) Pathways for YAP1
        Wnt / Hedgehog / Notch
    Tyrosine Kinases / Adaptors
    PI3K / Akt Signaling

    1 GeneGo (Thomson Reuters) Pathway for YAP1
        CFTR-dependent regulation of ion channels in Airway Epithelium (norm and CF)

    3 BioSystems Pathways for YAP1
        TGF-beta Receptor Signaling Pathway
    ErbB4 signaling events
    TGF-beta receptor signaling

    5/7        Reactome Pathways for YAP1 (see all 7)
        Signaling by Hippo
    Generic Transcription Pathway
    Signal Transduction
    Gene Expression
    Signaling by ERBB4


    1         Kegg Pathway  (Kegg details for YAP1):
        Hippo signaling pathway


    YAP1 for pathways           About GeneDecksing

    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for YAP1

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    5/87 Interacting proteins for YAP1 (P469371, 2, 3 ENSP000002824414) via UniProtKB, MINT, STRING, and/or I2D (see all 87)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    TP73O153502, 3, ENSP000003675454MINT-3388748 MINT-3388922 MINT-3388949 MINT-3388697 MINT-3388978 MINT-3388723 MINT-3388775 I2D: score=4 STRING: ENSP00000367545
    YWHABP319462, 3, ENSP000003001614MINT-8008033 MINT-8009689 I2D: score=1 STRING: ENSP00000300161
    BTRCQ9Y2972, 3, ENSP000003592064MINT-8249751 I2D: score=2 STRING: ENSP00000359206
    TP63Q9H3D42, 3, ENSP000002647314MINT-3388996 I2D: score=2 STRING: ENSP00000264731
    MED28Q9H2042, 3, ENSP000002373804MINT-7041969 I2D: score=1 STRING: ENSP00000237380
    About this table

    Gene Ontology (GO): 5/24 biological process terms (GO ID links to tree view) (see all 24):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0001570vasculogenesis IEA--
    GO:0003143embryonic heart tube morphogenesis IEA--
    GO:0006366transcription from RNA polymerase II promoter ----
    GO:0006367transcription initiation from RNA polymerase II promoter TAS--
    GO:0006974response to DNA damage stimulus IDA18280240

    YAP1 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section

    YAP1 for compounds           About GeneDecksing

    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for YAP1

    3 Novoseek inferred chemical compound relationships for YAP1 gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    tyrosine 15.6 5 14765127 (2), 11278685 (1), 16061658 (1)
    proline 12.5 2 8035999 (2)
    serine 3.3 2 8035999 (1), 19141641 (1)

    Search CenterWatch for drugs/clinical trials and news about YAP1

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for YAP1 gene (9 alternative transcripts): 
    NM_001130145.2  NM_001195044.1  NM_001195045.1  NM_001282097.1  NM_001282098.1  NM_001282099.1  NM_001282100.1  NM_001282101.1  
    NM_006106.4  

    Unigene Cluster for YAP1:

    Yes-associated protein 1
    Hs.503692  [show with all ESTs]
    Unigene Representative Sequence: NM_001130145
    9 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000526343 ENST00000282441(uc001pgt.3 uc001pgu.3 uc001pgv.3 uc021qpf.1 uc010ruo.2 uc001pgw.2 uc010rup.1)
    ENST00000531439 ENST00000524575 ENST00000526594 ENST00000529029 ENST00000528834
    ENST00000537274 ENST00000345877

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    8/27 QIAGEN miScript miRNA Assays for microRNAs that regulate YAP1 (see all 27):
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    Additional mRNA sequence: 

    AB567720.1 AB567721.1 AK300414.1 AK304485.1 AK310620.1 AK316116.1 AL832620.2 AY316529.1 
    BC026212.2 BC038235.1 HE864159.1 HE864160.1 HE864161.1 HE864162.1 HE864163.1 

    15 DOTS entries:

    DT.100824242  DT.446373  DT.91673001  DT.100043384  DT.91745842  DT.101979534  DT.120701800  DT.100824244 
    DT.307255  DT.120701732  DT.120701734  DT.120701753  DT.212517  DT.92436111  DT.100710900 

    24/292 AceView cDNA sequences (see all 292):

    BI261054 AI015834 AY316529 BX112895 AA973159 AI827322 AL832620 AA181566 
    BE504889 CA446426 AA781002 AA460703 AW058495 BQ893187 AI281049 BU619886 
    AA610311 BU622656 AI963820 AA182461 NM_006106 BQ880612 BQ008172 AI590105 

    GeneLoc Exon Structure

    5/7 Alternative Splicing Database (ASD) splice patterns (SP) for YAP1 (see all 7)    About this scheme

    ExUns: 1a · 1b ^ 2 ^ 3a · 3b ^ 4 ^ 5 ^ 6a · 6b ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12a · 12b · 12c · 12d · 12e · 12f
    SP1:              -                                               -           -                                             
    SP2:              -                                         -     -           -                                             
    SP3:                                                              -           -                                             
    SP4:                                      -                 -     -           -                                             
    SP5:                                                                                                                        


    ECgene alternative splicing isoforms for YAP1

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    YAP1 expression in normal human tissues (normalized intensities)      YAP1 embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: CTCATATGTT
    YAP1 Expression
    About this image


    YAP1 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database 
     5/4 selected tissues (see all 4) fully expand
     
     Endothelium (Cardiovascular System)    fully expand to see all 2 entries
             Human umbilical vein endothelial cells (HUVEC)
             Endothelial progenitor cells ( Derivation and purification of endothelial precursor...
     
     Trophoblast (Extraembryonic Tissues)    fully expand to see all 2 entries
             Trophoblast Cells Trophoblast
     
     Inner Cell Mass (Early Embryo)    fully expand to see all 2 entries
             Inner Cell Mass Cells Inner Cell Mass
     
     Zygote (Early Embryonic Tissues)
             Morula Cells Morula

    See YAP1 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for YAP1

    SOURCE GeneReport for Unigene cluster: Hs.503692

    UniProtKB/Swiss-Prot: YAP1_HUMAN, P46937
    Tissue specificity: Increased expression seen in some liver and prostate cancers. Isoforms lacking the
    transactivation domain found in striatal neurons of patients with Huntington disease (at protein level)

        SABiosciences Expression via Pathway-Focused PCR Array including YAP1: 
              Liver Cancer in human mouse rat

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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of animals.

    Orthologs for YAP1 gene from 6/13 species (see all 13)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Yap11 , 5 yes-associated protein 11, 5 87.92(n)1
    91.74(a)1
      9 (2.46 cM)5
    226011  NM_009534.31  NP_033560.11 
     79319995 
    chicken
    (Gallus gallus)
    Aves YAP11 Yes-associated protein 1 82.22(n)
    89.06(a)
      396171  NM_205243.1  NP_990574.1 
    lizard
    (Anolis carolinensis)
    Reptilia YAP16
    Yes-associated protein 1
    88(a)
    1 ↔ 1
    3(192366647-192475998)
    African clawed frog
    (Xenopus laevis)
    Amphibia Xl.76562 Xenopus laevis transcribed sequence with moderate similarity more 79.48(n)    BJ619727.1 
    zebrafish
    (Danio rerio)
    Actinopterygii Dr.126982 Transcribed sequence with moderate similarity to protein more 76.72(n)    CD750884.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta yki6
    yorkie
    22(a)
    1 → many
    2R(19953498-19956008)


    ENSEMBL Gene Tree for YAP1 (if available)
    TreeFam Gene Tree for YAP1 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for YAP1 gene
    WWTR12  
    4 SIMAP similar genes for YAP1 using alignment to 9 protein entries:     YAP1_HUMAN (see all proteins):
    YAP    DKFZp451O0517    WWC2    WWTR1

    YAP1 for paralogs           About GeneDecksing


    3 Pseudogenes.org Pseudogenes for YAP1
    PGOHUM00000243353 PGOHUM00000243810 PGOHUM00000241958


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/2566 SNPs in YAP1 are shown (see all 2566)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 11 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs359870471,2
    C--97912811(+) TACAG-/TTTTTT 4 -- int10--------
    rs360922011,2
    C--97912856(+) TCTTCT/-TTTTT 4 -- int11Minor allele frequency- -:0.50CSA 2
    rs105697171,2
    C--97916897(+) CTTGG-/AAAAAAA 4 -- int10--------
    rs1127917781,2
    C--97918693(+) GTCTCA/-AAAAA 4 -- int11Minor allele frequency- -:0.00CSA 2
    rs1117211251,2
    C--97922622(+) CATTCTT/-TTTTT 4 -- int11Minor allele frequency- -:0.50CSA 2
    rs1413618821,2
    C--97922643(+) TTTTC-/TTTTTTT 4 -- int10--------
    rs113713451,2
    C--97926229(+) CTCTCT/-GCTTC 4 -- int11Minor allele frequency- -:0.50CSA 2
    rs1390542731,2
    C--97926883(+) TCTCC-/AAAAAAA 4 -- int10--------
    rs721282381,2
    C--97930309(+) TAAAT-/AAAC  
            
    AAACA
    4 -- int10--------
    rs560741291,2
    C--97930312(+) ATAAAT/CAAACA 4 -- int11Minor allele frequency- C:0.00NA 2

    HapMap Linkage Disequilibrium report for YAP1 (101981192 - 102104154 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 3 variations for YAP1:    About this table     
    Variant IDTypeSubtypePubMed ID
    esv2524266CNV Deletion19546169
    nsv832251CNV Loss17160897
    nsv898333CNV Gain21882294


    Human Gene Mutation Database (HGMD): YAP1
    SABiosciences Cancer Mutation PCR Assays
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    DNA2.0 Custom Variant and Variant Library Synthesis for YAP1

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 606608    OMIM disorders: --

    20/26 diseases for YAP1 (see all 26):    About MalaCards
    japanese spotted fever    spotted fever    neurofibromatosis    pancreatic ductal adenocarcinoma
    medulloblastoma    polycystic ovary syndrome    oral squamous cell carcinoma    huntington's disease
    meningioma    glioblastoma    gastric cancer    squamous cell carcinoma
    sarcoma    hepatocellular carcinoma    adenocarcinoma    esophagitis
    lung cancer    ovarian cancer    pancreatic cancer    alzheimer's disease

    1 disease from the University of Copenhagen DISEASES database for YAP1:
    Japanese spotted fever

    YAP1 for disorders           About GeneDecksing


    Congresses - knowledge worth sharing:  
    Alzheimer's & Parkinson's Diseases Congress (ADPD) 18 - 22 March 2015

    2 Novoseek inferred disease relationships for YAP1 gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    tumors 31.6 20 19551889 (4), 20226166 (2), 19952108 (1), 20123905 (1) (see all 15)
    cancer 20.2 11 16596258 (3), 18703216 (3), 19371381 (1), 18953429 (1) (see all 6)

    Genetic Association Database (GAD): YAP1
    Human Genome Epidemiology (HuGE) Navigator: YAP1 (2 documents)

    Export disorders for YAP1 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for YAP1 gene, integrated from 9 sources (see all 208):
    (articles sorted by number of sources associating them with YAP1)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Characterization of the mammalian YAP (Yes-associated protein) gene and its role in defining a novel protein module, the WW domain. (PubMed id 7782338)1, 2, 3, 9 Sudol M.... Lehman D. (1995)
    2. A coordinated phosphorylation by Lats and CK1 regulat es YAP stability through SCF(beta-TRCP). (PubMed id 20048001)1, 2, 9 Zhao B....Guan K.L. (2010)
    3. WW domain-containing protein YAP associates with ErbB-4 and acts as a co-transcriptional activator for the carboxyl-terminal fragment of ErbB-4 that translocates to the nucleus. (PubMed id 12807903)1, 2, 9 Komuro A.... Sudol M. (2003)
    4. Inactivation of YAP oncoprotein by the Hippo pathway is involved in cell contact inhibition and tissue growth control. (PubMed id 17974916)1, 2, 9 Zhao B.... Guan K.L. (2007)
    5. JNK phosphorylates Yes-associated protein (YAP) to regulate apoptosis. (PubMed id 21364637)1, 2 Tomlinson V....Basu S. (2010)
    6. Genome-wide interrogation identifies YAP1 variants as sociated with survival of small-cell lung cancer patients. (PubMed id 21118971)1, 4 Wu C....Lin D. (2010)
    7. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PubMed id 20379614)1, 4 Rose J.E....Uhl G.R. (2010)
    8. Genome-wide association with MRI atrophy measures as a quantitative trait locus for Alzheimer's disease. (PubMed id 21116278)1, 4 Furney S.J....Lovestone S. (2010)
    9. Tumor suppressor LATS1 is a negative regulator of oncogene YAP. (PubMed id 18158288)1, 2 Hao Y....Yang X. (2008)
    10. Yap1 phosphorylation by c-Abl is a critical step in selective activation of proapoptotic genes in response to DNA damage. (PubMed id 18280240)1, 2 Levy D....Shaul Y. (2008)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 10413 HGNC: 16262 AceView: YAP1 Ensembl:ENSG00000137693 euGenes: HUgn10413
    ECgene: YAP1 Kegg: 10413 H-InvDB: YAP1

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for YAP1 Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for YAP1 Genetics and Cytogenetics in Oncology and Haematology

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for YAP1 gene:
    Search GeneIP for patents involving YAP1

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Sirion Biotech, Cell lines from GenScript, and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences, In Situ Hybridization Assays from
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    About This Section

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