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YAP1 Gene

protein-coding   GIFtS: 66
GCID: GC11P102015

Yes-Associated Protein 1

(Previous names: Yes-associated protein 1, 65kDa)
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Yes-Associated Protein 11 2     YAP22
65 KDa Yes-Associated Protein2 3     YKI2
YAP652 3     Yes-Associated Protein 22
Yes-Associated Protein 1, 65kDa1     Yorkie Homolog2
YAP2     

External Ids:    HGNC: 162621   Entrez Gene: 104132   Ensembl: ENSG000001376937   OMIM: 6066085   UniProtKB: P469373   

Export aliases for YAP1 gene to outside databases

Previous GC identifers: GC11P104175 GC11P103338 GC11P101519 GC11P101486 GC11P097907


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for YAP1 Gene:
This gene encodes a downstream nuclear effector of the Hippo signaling pathway which is involved in development,
growth, repair, and homeostasis. This gene is known to play a role in the development and progression of multiple
cancers as a transcriptional regulator of this signaling pathway and may function as a potential target for
cancer treatment. Alternative splicing results in multiple transcript variants encoding different isoforms.
(provided by RefSeq, Aug 2013)

GeneCards Summary for YAP1 Gene:
YAP1 (Yes-associated protein 1) is a protein-coding gene. Diseases associated with YAP1 include uveal coloboma - cleft lip and palate - intellectual deficit, and japanese spotted fever. GO annotations related to this gene include chromatin binding and transcription corepressor activity. An important paralog of this gene is WWTR1.

UniProtKB/Swiss-Prot: YAP1_HUMAN, P46937
Function: Transcriptional regulator which can act both as a coactivator and a corepressor and is the critical
downstream regulatory target in the Hippo signaling pathway that plays a pivotal role in organ size control and
tumor suppression by restricting proliferation and promoting apoptosis. The core of this pathway is composed of a
kinase cascade wherein STK3/MST2 and STK4/MST1, in complex with its regulatory protein SAV1, phosphorylates and
activates LATS1/2 in complex with its regulatory protein MOB1, which in turn phosphorylates and inactivates YAP1
oncoprotein and WWTR1/TAZ. Plays a key role to control cell proliferation in response to cell contact.
Phosphorylation of YAP1 by LATS1/2 inhibits its translocation into the nucleus to regulate cellular genes
important for cell proliferation, cell death, and cell migration. The presence of TEAD transcription factors are
required for it to stimulate gene expression, cell growth, anchorage-independent growth, and epithelial
mesenchymal transition (EMT) induction. Isoform 2 and isoform 3 can activate the C-terminal fragment (CTF) of
ERBB4 (isoform 3)

Gene Wiki entry for YAP1 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence:
NC_000011.10  NT_033899.9  NC_018922.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the YAP1 gene promoter:
         TBP   p53   AP-1   p300   ATF-2   JunD   TFIID   c-Jun   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidYAP1 promoter sequence
   Search Chromatin IP Primers for YAP1

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat YAP1


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 11q13   Ensembl cytogenetic band:  11q22.1   HGNC cytogenetic band: 11q13

YAP1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
YAP1 gene location

GeneLoc information about chromosome 11         GeneLoc Exon Structure

GeneLoc location for GC11P102015:  view genomic region     (about GC identifiers)

Start:
101,981,192 bp from pter      End:
102,104,154 bp from pter
Size:
122,963 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: YAP1_HUMAN, P46937 (See protein sequence)
Recommended Name: Yorkie homolog  
Size: 504 amino acids; 54462 Da
Subunit: Binds to the SH3 domain of the YES kinase. Binds to WBP1 and WBP2. Binds, in vitro, through the WW1
domain, to neural isoforms of ENAH that contain the PPSY motif (By similarity). The phosphorylated form interacts
with YWHAB. Interacts (via WW domains) with LATS1 (via PPxY motif 2). Interacts with LATS2. Isoform 2 and isoform
3 interact (via WW domain 1) with isoform 3 of ERBB4 (via PPxY motif 2). Interacts with TEAD1, TEAD2, TEAD3 and
TEAD4. Interacts with TP73. Interacts with RUNX1. Interacts with HCK. Interacts (via WW domains) with PTPN14 (via
PPxY motif 2); this interaction leads to the cytoplasmic sequestration of YAP1 and inhibits its transcriptional
coactivator activity
Selected PDB 3D structures from and Proteopedia for YAP1 (see all 11):
1JMQ (3D)        1K5R (3D)        1K9Q (3D)        1K9R (3D)        2LAW (3D)        2LAX (3D)    
Secondary accessions: B4DTY1 B7ZA01 E3WEB5 E3WEB6 E9PRV2 F5H202 K0KQ18 K0KYZ8 K0L195 K0L1G3
Q7Z574 Q8IUY9
Alternative splicing: 9 isoforms:  P46937-1   P46937-2   P46937-3   P46937-4   P46937-5   P46937-6   P46937-7   P46937-8   
P46937-9   (Highest expression in ovary and placenta, lowest in skeletal muscle and brain)

Explore the universe of human proteins at neXtProt for YAP1: NX_P46937

Explore proteomics data for YAP1 at MOPED

Post-translational modifications: 

  • Phosphorylated by LATS1 and LATS2; leading to cytoplasmic translocation and inactivation. Phosphorylated by ABL1;
    leading to YAP1 stabilization, enhanced interaction with TP73 and recruitment onto proapoptotic genes; in
    response to DNA damage. Phosphorylation at Ser-400 and Ser-403 by CK1 is triggered by previous phosphorylation at
    Ser-397 by LATS proteins and leads to YAP1 ubiquitination by SCF(beta-TRCP) E3 ubiquitin ligase and subsequent
    degradation. Phosphorylated at Thr-119, Ser-138, Thr-154, Ser-367 and Thr-412 by MAPK8/JNK1 and MAPK9/JNK2, which
    is required for the regukation of apoptosis by YAP11
  • Ubiquitinated by SCF(beta-TRCP) E3 ubiquitin ligase1
  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus

  • See YAP1 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (9 alternative transcripts): 
    NP_001123617.1  NP_001181973.1  NP_001181974.1  NP_001269026.1  NP_001269027.1  NP_001269028.1  NP_001269029.1  NP_001269030.1  
    NP_006097.2  

    ENSEMBL proteins: 
     ENSP00000434134   ENSP00000282441   ENSP00000431574   ENSP00000435602   ENSP00000431626  
     ENSP00000445635   ENSP00000331023  
    Reactome Protein details: P46937

    YAP1 Human Recombinant Protein Products:

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    Novus Biologicals YAP1 Proteins
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    YAP1 Antibody Products:

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    YAP1 Assay Products:

    Browse Kits and Assays available from EMD Millipore
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    Browse Enzo Life Sciences for kits & assays
    Cloud-Clone Corp. ELISAs for YAP1
    Cloud-Clone Corp. CLIAs for YAP1


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    1 InterPro protein domain:
     IPR001202 WW_dom

    Graphical View of Domain Structure for InterPro Entry P46937

    ProtoNet protein and cluster: P46937

    1 Blocks protein domain: IPB002349 WW domain signature

    UniProtKB/Swiss-Prot: YAP1_HUMAN, P46937
    Domain: The first coiled-coil region mediates most of the interaction with TEAD transcription factors
    Similarity: Belongs to the YORKIE family
    Similarity: Contains 2 WW domains


    YAP1 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: YAP1_HUMAN, P46937
    Function: Transcriptional regulator which can act both as a coactivator and a corepressor and is the critical
    downstream regulatory target in the Hippo signaling pathway that plays a pivotal role in organ size control and
    tumor suppression by restricting proliferation and promoting apoptosis. The core of this pathway is composed of a
    kinase cascade wherein STK3/MST2 and STK4/MST1, in complex with its regulatory protein SAV1, phosphorylates and
    activates LATS1/2 in complex with its regulatory protein MOB1, which in turn phosphorylates and inactivates YAP1
    oncoprotein and WWTR1/TAZ. Plays a key role to control cell proliferation in response to cell contact.
    Phosphorylation of YAP1 by LATS1/2 inhibits its translocation into the nucleus to regulate cellular genes
    important for cell proliferation, cell death, and cell migration. The presence of TEAD transcription factors are
    required for it to stimulate gene expression, cell growth, anchorage-independent growth, and epithelial
    mesenchymal transition (EMT) induction. Isoform 2 and isoform 3 can activate the C-terminal fragment (CTF) of
    ERBB4 (isoform 3)

         Gene Ontology (GO): Selected molecular function terms (see all 7):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0001076RNA polymerase II transcription factor binding transcription factor activity IEA--
    GO:0003682chromatin binding IEA--
    GO:0003713transcription coactivator activity IDA18158288
    GO:0003714transcription corepressor activity IDA18158288
    GO:0005515protein binding IPI11278422
         
    YAP1 for ontologies           About GeneDecksing


    Phenotypes:
         4 GenomeRNAi human phenotypes for YAP1:
     Decreased NANOG protein expres  Decreased OCT4 protein express  Decreased POU5F1-GFP protein e  Decreased viability of wild-ty 

         Selected MGI mutant phenotypes (inferred from 7 alleles(MGI details for Yap1) (see all 17):
     behavior/neurological  cardiovascular system  cellular  digestive/alimentary  embryogenesis 
     endocrine/exocrine gland  growth/size/body  homeostasis/metabolism  immune system  integument 
     liver/biliary system  mortality/aging  muscle  nervous system  renal/urinary system 

    YAP1 for phenotypes           About GeneDecksing

    Animal Models:
         MGI mouse knock-outs for YAP1: Yap1tm1Smil Yap1tm1.2Dupa

       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for YAP1
       inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for YAP1

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for YAP1
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for YAP1

    miRNA
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    miRTarBase miRNAs that target YAP1:
    hsa-mir-630 (MIRT005580), hsa-mir-26b-5p (MIRT030244), hsa-mir-200a-3p (MIRT007299), hsa-mir-375 (MIRT006154), hsa-let-7b-5p (MIRT005047)

    Block miRNA regulation of human, mouse, rat YAP1 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate YAP1 (see all 27):
    hsa-miR-411* hsa-miR-3130-5p hsa-miR-379* hsa-miR-199b-3p hsa-miR-199a-3p hsa-miR-3942-5p hsa-miR-15a hsa-miR-200a
    Browse SwitchGear 3'UTR luciferase reporter plasmids
    Inhib. RNA
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    Predesigned siRNA for gene silencing in human, mouse, rat YAP1

    Gene Editing
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    Clone
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    GenScript: all cDNA clones in your preferred vector (see all 2): YAP1 (NM_001117)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for YAP1
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat YAP1

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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for YAP1


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    YAP1_HUMAN, P46937: Cytoplasm. Nucleus. Note=Both phosphorylation and cell density can regulate its subcellular
    localization. Phosphorylation sequesters it in the cytoplasm by inhibiting its translocation into the nucleus. At
    low density, predominantly nuclear and is translocated to the cytoplasm at high density. PTPN14 induces
    translocation from the nucleus to the cytoplasm
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    nucleus5
    cytosol4

    Gene Ontology (GO): 5 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus IDA17974916
    GO:0005654nucleoplasm TAS--
    GO:0005667transcription factor complex IEA--
    GO:0005737cytoplasm IDA17974916
    GO:0005829cytosol TAS--

    YAP1 for ontologies           About GeneDecksing


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for YAP1 About   (see all 19)  
    See pathways by source

    SuperPathContained pathways About
    1Fatty acid, triacylglycerol, and ketone body metabolism
    Fatty acid, triacylglycerol, and ketone body metabolism0.65
    PPARA Activates Gene Expression0.63
    Regulation of Lipid Metabolism by Peroxisome proliferator-activated receptor alpha (PPARalpha)0.65
    2Gene Expression
    Generic Transcription Pathway0.40
    Gene Expression0.40
    3Metabolism
    Metabolism0.38
    Metabolism of lipids and lipoproteins0.37
    4PI-3K cascade
    Signaling by ERBB40.66
    5Akt Signaling
    Akt Signaling0.60

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    3 Downloadable PowerPoint Slides of GeneGlobe Pathway Central Maps for YAP1
        14-3-3 and Regulation of BAD Activity
    14-3-3 Induced Intracellular Signaling
    Akt Signaling

    3 Cell Signaling Technology (CST) Pathways for YAP1
        Wnt / Hedgehog / Notch
    Tyrosine Kinases / Adaptors
    PI3K / Akt Signaling

    1 GeneGo (Thomson Reuters) Pathway for YAP1
        CFTR-dependent regulation of ion channels in Airway Epithelium (norm and CF)

    3 BioSystems Pathways for YAP1
        TGF-beta Receptor Signaling Pathway
    ErbB4 signaling events
    TGF-beta receptor signaling

    4 Reactome Pathways for YAP1
        Signaling by Hippo
    PPARA activates gene expression
    YAP1- and WWTR1 (TAZ)-stimulated gene expression
    Nuclear signaling by ERBB4


    1 Kegg Pathway  (Kegg details for YAP1):
        Hippo signaling pathway


    YAP1 for pathways           About GeneDecksing

        Pathway & Disease-focused RT2 Profiler PCR Array including YAP1: 
              Liver Cancer in human mouse rat

    Interactions:

        GeneGlobe Interaction Network for YAP1

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for YAP1 (P469371, 2, 3 ENSP000002824414) via UniProtKB, MINT, STRING, and/or I2D (see all 126)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    Wbp1P977641, 2EBI-1044059,EBI-6304160 MINT-3177889 MINT-3178651 MINT-3165041 MINT-3177984 MINT-3162303 MINT-3164295 MINT-3177402 MINT-3163700 MINT-3178037 MINT-3179541 MINT-3164832 MINT-3179482 MINT-3164887
    YWHABP319461, 2, 3, ENSP000003001614EBI-1044059,EBI-359815 MINT-8008033 MINT-8009689 I2D: score=1 STRING: ENSP00000300161
    YWHAZP631041, 2, 3EBI-1044059,EBI-347088 MINT-3317930 MINT-3295934 I2D: score=1 
    TP63Q9H3D42, 3, ENSP000002647314MINT-3388996 I2D: score=2 STRING: ENSP00000264731
    MED28Q9H2042, 3, ENSP000002373804MINT-7041969 I2D: score=1 STRING: ENSP00000237380
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 25):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0001570vasculogenesis IEA--
    GO:0003143embryonic heart tube morphogenesis IEA--
    GO:0006366transcription from RNA polymerase II promoter ----
    GO:0006367transcription initiation from RNA polymerase II promoter TAS--
    GO:0006974cellular response to DNA damage stimulus IDA18280240

    YAP1 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for YAP1

    3 Novoseek inferred chemical compound relationships for YAP1 gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    tyrosine 15.6 5 14765127 (2), 11278685 (1), 16061658 (1)
    proline 12.5 2 8035999 (2)
    serine 3.3 2 8035999 (1), 19141641 (1)



    YAP1 for compounds           About GeneDecksing



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
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    REFSEQ mRNAs for YAP1 gene (9 alternative transcripts): 
    NM_001130145.2  NM_001195044.1  NM_001195045.1  NM_001282097.1  NM_001282098.1  NM_001282099.1  NM_001282100.1  NM_001282101.1  
    NM_006106.4  

    Unigene Cluster for YAP1:

    Yes-associated protein 1
    Hs.503692  [show with all ESTs]
    Unigene Representative Sequence: NM_001130145
    9 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000526343 ENST00000282441(uc001pgt.3 uc001pgu.3 uc001pgv.3 uc021qpf.1 uc010ruo.2 uc001pgw.2 uc010rup.1)
    ENST00000531439 ENST00000524575 ENST00000526594 ENST00000529029 ENST00000528834
    ENST00000537274 ENST00000345877
    miRNA
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    Selected qRT-PCR Assays for microRNAs that regulate YAP1 (see all 27):
    hsa-miR-411* hsa-miR-3130-5p hsa-miR-379* hsa-miR-199b-3p hsa-miR-199a-3p hsa-miR-3942-5p hsa-miR-15a hsa-miR-200a
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    Primer
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      QuantiFast Probe-based Assays in human, mouse, rat YAP1

    Additional mRNA sequence: 

    AB567720.1 AB567721.1 AK300414.1 AK304485.1 AK310620.1 AK316116.1 AL832620.2 AY316529.1 
    BC026212.2 BC038235.1 HE864159.1 HE864160.1 HE864161.1 HE864162.1 HE864163.1 

    15 DOTS entries:

    DT.100824242  DT.446373  DT.91673001  DT.100043384  DT.91745842  DT.101979534  DT.120701800  DT.100824244 
    DT.307255  DT.120701732  DT.120701734  DT.120701753  DT.212517  DT.92436111  DT.100710900 

    Selected AceView cDNA sequences (see all 292):

    CA446426 BE504889 AA181566 AI827322 BI261054 AA781002 AA460703 BQ893187 
    AW058495 AY316529 AI281049 BU619886 AI015834 AA610311 AI005171 BU622656 
    AI963820 BX112895 AA182461 NM_006106 BQ880612 BM825245 AW081855 BQ008172 

    GeneLoc Exon Structure

    Selected Alternative Splicing Database (ASD) splice patterns (SP) for YAP1 (see all 7)    About this scheme

    ExUns: 1a · 1b ^ 2 ^ 3a · 3b ^ 4 ^ 5 ^ 6a · 6b ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12a · 12b · 12c · 12d · 12e · 12f
    SP1:              -                                               -           -                                             
    SP2:              -                                         -     -           -                                             
    SP3:                                                              -           -                                             
    SP4:                                      -                 -     -           -                                             
    SP5:                                                                                                                        


    ECgene alternative splicing isoforms for YAP1

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    YAP1 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: CTCATATGTT
    YAP1 Expression
    About this image


    YAP1 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 13) fully expand
     
     Smooth Muscle (Muscoskeletal System)
             Contractile smooth muscle-like cells
     
     NULL (Uncategorized)
             Vascular endothelial growth factor-induced cells
     
     Inner Cell Mass (Early Embryonic Tissues)
             Inner Cell Mass Cells Inner Cell Mass
     
     Trophoblast (Extraembryonic Tissues)
             Trophoblast Cells Trophoblast
     
     Endothelium (Cardiovascular System)
             Human umbilical vein endothelial cells (HUVEC)
    YAP1 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    YAP1 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.503692

    UniProtKB/Swiss-Prot: YAP1_HUMAN, P46937
    Tissue specificity: Increased expression seen in some liver and prostate cancers. Isoforms lacking the
    transactivation domain found in striatal neurons of patients with Huntington disease (at protein level)

        Pathway & Disease-focused RT2 Profiler PCR Array including YAP1: 
              Liver Cancer in human mouse rat

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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of animals.

    Orthologs for YAP1 gene from Selected species (see all 13)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Yap11 , 5 yes-associated protein 11, 5 88.71(n)1
    93.14(a)1
      9 (2.46 cM)5
    226011  NM_009534.31  NP_033560.11 
     79319995 
    chicken
    (Gallus gallus)
    Aves YAP11 Yes-associated protein 1 85.05(n)
    94.49(a)
      396171  NM_205243.1  NP_990574.1 
    lizard
    (Anolis carolinensis)
    Reptilia YAP16
    Yes-associated protein 1
    86(a)
    1 ↔ 1
    3(192366647-192475998)
    African clawed frog
    (Xenopus laevis)
    Amphibia Xl.76562 Xenopus laevis transcribed sequence with moderate similarity more 79.48(n)    BJ619727.1 
    zebrafish
    (Danio rerio)
    Actinopterygii Dr.126982 Transcribed sequence with moderate similarity to protein more 76.72(n)    CD750884.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta yki6
    yorkie
    23(a)
    1 → many
    2R(19953498-19956008)


    ENSEMBL Gene Tree for YAP1 (if available)
    TreeFam Gene Tree for YAP1 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for YAP1 gene
    WWTR12  
    3 SIMAP similar genes for YAP1 using alignment to 3 protein entries:     YAP1_HUMAN (see all proteins):
    DKFZp451O0517    WWC2    WWTR1

    YAP1 for paralogs           About GeneDecksing


    3 Pseudogenes.org Pseudogenes for YAP1
    PGOHUM00000243353 PGOHUM00000243810 PGOHUM00000241958


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for YAP1 (see all 2566)    About this table    
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 11 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs359870471,2
    C--97912811(+) TACAG-/TTTTTT 4 -- int10--------
    rs360922011,2
    C--97912856(+) TCTTCT/-TTTTT 4 -- int11Minor allele frequency- -:0.50CSA 2
    rs105697171,2
    C--97916897(+) CTTGG-/AAAAAAA 4 -- int10--------
    rs1127917781,2
    C--97918693(+) GTCTCA/-AAAAA 4 -- int11Minor allele frequency- -:0.00CSA 2
    rs1117211251,2
    C--97922622(+) CATTCTT/-TTTTT 4 -- int11Minor allele frequency- -:0.50CSA 2
    rs1413618821,2
    C--97922643(+) TTTTC-/TTTTTTT 4 -- int10--------
    rs113713451,2
    C--97926229(+) CTCTCT/-GCTTC 4 -- int11Minor allele frequency- -:0.50CSA 2
    rs1390542731,2
    C--97926883(+) TCTCC-/AAAAAAA 4 -- int10--------
    rs721282381,2
    C--97930309(+) TAAAT-/AAAC  
            
    AAACA
    4 -- int10--------
    rs560741291,2
    C--97930312(+) ATAAAT/CAAACA 4 -- int11Minor allele frequency- C:0.00NA 2

    HapMap Linkage Disequilibrium report for YAP1 (101981192 - 102104154 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 3 variations for YAP1:    About this table    
    Variant IDTypeSubtypePubMed ID
    esv2524266CNV Deletion19546169
    nsv832251CNV Loss17160897
    nsv898333CNV Gain21882294

    Human Gene Mutation Database (HGMD): YAP1
    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing YAP1
    DNA2.0 Custom Variant and Variant Library Synthesis for YAP1

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 606608   
    OMIM disorders: 120433  
    Selected diseases for YAP1 (see all 34):    
    About MalaCards
    uveal coloboma - cleft lip and palate - intellectual deficit    japanese spotted fever    spotted fever    neurofibromatosis
    pancreatic ductal adenocarcinoma    polycystic ovary syndrome    soft tissue sarcoma    malignant mesothelioma
    medulloblastoma    gastric adenocarcinoma    meningioma    oral squamous cell carcinoma
    huntington's disease    myopathy    pancreatitis    esophageal squamous cell carcinoma
    squamous cell carcinoma    osteosarcoma    hepatocellular carcinoma    sarcoma

    1 disease from the University of Copenhagen DISEASES database for YAP1:
    Japanese spotted fever

    YAP1 for disorders           About GeneDecksing

    2 Novoseek inferred disease relationships for YAP1 gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    tumors 31.6 20 19551889 (4), 20226166 (2), 19952108 (1), 20123905 (1) (see all 15)
    cancer 20.2 11 16596258 (3), 18703216 (3), 19371381 (1), 18953429 (1) (see all 6)

    Genetic Association Database (GAD): YAP1
    Human Genome Epidemiology (HuGE) Navigator: YAP1 (2 documents)

    Export disorders for YAP1 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for YAP1 gene, integrated from 10 sources (see all 234):
    (articles sorted by number of sources associating them with YAP1)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Characterization of the mammalian YAP (Yes-associated protein) gene and its role in defining a novel protein module, the WW domain. (PubMed id 7782338)1, 2, 3, 9 Sudol M.... Lehman D. (J. Biol. Chem. 1995)
    2. A coordinated phosphorylation by Lats and CK1 regulates YAP stability through SCF(beta-TRCP). (PubMed id 20048001)1, 2, 9 Zhao B.... Guan K.-L. (Genes Dev. 2010)
    3. WW domain-containing protein YAP associates with ErbB-4 and acts as a co-transcriptional activator for the carboxyl-terminal fragment of ErbB-4 that translocates to the nucleus. (PubMed id 12807903)1, 2, 9 Komuro A.... Sudol M. (J. Biol. Chem. 2003)
    4. Inactivation of YAP oncoprotein by the Hippo pathway is involved in cell contact inhibition and tissue growth control. (PubMed id 17974916)1, 2, 9 Zhao B.... Guan K.L. (Genes Dev. 2007)
    5. Identification, basic characterization and evolutionary analysis of differentially spliced mRNA isoforms of human YAP1 gene. (PubMed id 22939869)1, 2 Gaffney C.J....Sudol M. (Gene 2012)
    6. Genome-wide association with MRI atrophy measures as a quantitative trait locus for Alzheimer's disease. (PubMed id 21116278)1, 4 Furney S.J.... . (Mol. Psychiatry 2011)
    7. JNK phosphorylates Yes-associated protein (YAP) to regulate apoptosis. (PubMed id 21364637)1, 2 Tomlinson V....Basu S. (Cell Death Dis. 2010)
    8. Genome-wide interrogation identifies YAP1 variants associated with survival of small-cell lung cancer patients. (PubMed id 21118971)1, 4 Wu C....Lin D. (Cancer Res. 2010)
    9. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PubMed id 20379614)1, 4 Rose J.E....Uhl G.R. (Mol. Med. 2010)
    10. Tumor suppressor LATS1 is a negative regulator of oncogene YAP. (PubMed id 18158288)1, 2 Hao Y.... Yang X. (J. Biol. Chem. 2008)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 10413 HGNC: 16262 AceView: YAP1 Ensembl:ENSG00000137693 euGenes: HUgn10413
    ECgene: YAP1 Kegg: 10413 H-InvDB: YAP1

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for YAP1 Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for YAP1 Genetics and Cytogenetics in Oncology and Haematology

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for YAP1 gene:
    Search GeneIP for patents involving YAP1

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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