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Aliases & Descriptions for YAP1
(According to
1 HGNC ,
2 Entrez Gene ,
3 UniProtKB/Swiss-Prot ,
4 UniProtKB/TrEMBL , 5 OMIM , 6 GeneLoc
, and/or 7 Ensembl ,
8 miRBase )About This Section
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Aliases YAP 2 YAP2 2 YAP65 1 , 2 , 3 YKI 2
Descriptions Yes-associated protein 1, 65 kDa 1 Yes-associated protein 1, 65kDa 2 yes-associated protein 2 2
Search outside databases for aliases for YAP1 genePrevious GC identifers: GC11P104175 GC11P103338 GC11P102015 GC11P101519
Summaries for YAP1 (According to Entrez Gene ,
Wikipedia's
Gene Wiki ,
UniProtKB/Swiss-Prot ,
and/or
UniProtKB/TrEMBL )
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EntrezGene summary for YAP1 : This gene encodes the human ortholog of chicken YAP protein which binds to the SH3 domain of theYes proto-oncogene product. This protein contains a WW domain that is found in various structural,regulatory and signaling molecules in yeast, nematode, and mammals, and may be involved inprotein-protein interaction. [provided by RefSeq] Gene Wiki entry for YAP1
Genomic Location for YAP1
(According to
GeneLoc and/or
HGNC , and/or
Entrez Gene (NCBI build 36) ,
and/or miRBase ,
Genomic Views according to
UCSC and
Ensembl ,
Transcription factor binding sites according to
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Genomic View : UCSC Golden Path with GeneCards custom track Transcription factor binding sites upstream to the YAP1 gene Entrez Gene cytogenetic band: 11q13 Ensembl cytogenetic band: 11q22.1 HGNC cytogenetic band: 11q13 YAP1 Gene in genomic location: bands according to Ensembl, locations according to
(and/or Entrez Gene and/or Ensembl if different) GeneLoc gene densities for chromosome 11 GeneLoc Exon Structure
GeneLoc location for GC11P101486:
(about GC identifiers )
Start:
101,486,497 bp from pter
End:
101,609,359 bp from pter
Size:
122,863 bases
Orientation:
plus strand
RefSeq DNA sequence: NC_000011.8 NT_033899.7 Proteins for YAP1
(According to
1 UniProtKB ,
and/or Ensembl ,
Phosphorylation sites according to 2 Phosphosite ,
RefSeq according to NCBI ,
PDB rendering according to OCA and/or Proteopedia ,
Recombinant Proteins
from Invitrogen ,
Millipore ,
Sigma-Aldrich ,
R&D Systems ,
Enzo Life Sciences ,
Abnova ,
OriGene and/or,
Abcam ,
Biochemical Assays by
Invitrogen ,
Millipore ,
R&D Systems ,
Cell Signaling Technology , and/or
Enzo Life Sciences ,
Ontologies according to Gene
Ontology Consortium 01 Apr 2009 and
Entrez Gene ,
Antibodies by Invitrogen ,
Millipore ,
Sigma-Aldrich ,
R&D Systems ,
Cell Signaling Technology ,
Abcam ,
Abnova , and/or
Novus Biologicals )
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UniProtKB/Swiss-Prot: YAP1_HUMAN, P46937 (See
protein sequence )Recommended Name: 65 kDa Yes-associated protein Size : 454 amino acids; 48755 Da
Subunit : Binds to the SH3 domain of the YES kinase. Binds to WBP1 and WBP2. Binds, in vitro,through the WW1 domain, to neural isoforms of ENAH that contain the PPSY motif (By similarity)
PDB structures from and Proteopedia : 1JMQ (3D)
 1K5R (3D)
 1K9Q (3D)
 1K9R (3D)
 
Post-translational modifications:
Phosphorylated upon DNA damage, probably by ATM or ATR1
View phosphorylation sites using PhosphoSite 2
REFSEQ proteins (2 alternative transcripts):
NP_001123617.1 NP_006097.1 ENSEMBL proteins: ENSP00000331023 ENSP00000282441 Human Recombinant Proteins               OriGene Purified Recombinant Human Protein: YAP1 Antibodies for YAP1: Assays for YAP1:
Protein
Domains/ Families for YAP1(According to InterPro , ProtoNet ,
UniProtKB , and/or BLOCKS ,
Sets of similar genes according to GeneDecks )
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Graphical View of Domain Structure for InterPro Entry P46937 ProtoNet protein and cluster: P46937
1 Blocks protein family : IPB002349 WW domain signature UniProtKB/Swiss-Prot: YAP1_HUMAN, P46937 Similarity : Contains 1 WW domain
Gene Function for YAP1
(According to MGI Jun 06 2009, UniProtKB ,
IUBMB ,and/or Genatlas ,
shRNA from
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Sigma-Aldrich , RNAi from
Sigma-Aldrich ,
RNAi Products ,
Clones , and
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Millipore ,
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SYBR primers from OriGene ,
Cell-based Assays from Millipore ,
Ontologies according to Gene Ontology Consortium 01 Apr 2009 via
Entrez Gene .)
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               OriGene 29mer shRNA kit in GFP-retroviral vectors (see all 2 ): NM_001130145 Applied Biosystems Silencer ® siRNAs for YAP1 Sigma-Aldrich siRNA for YAP1 Sigma-Aldrich shRNA for YAP1 Explore Sigma-Aldrich super-pooled esiRNAs                OriGene GFP tagged cDNA clones in CMV expression vector (see all 2 ): NM_001130145                                  Myc/DDK tagged cDNA clones in CMV expression vector (see all 2 ): NM_001130145                                  untagged cDNA clones in CMV expression vector (see all 2 ): NM_001130145  Primers: Browse
Quantitative PCR Central at Invitrogen for Q-PCR LUX™ Primers               OriGene genome-wide validated SYBR primer pairs: NM_001130145
5 MGI mutant phenotypes (inferred from 1 allele ) (MGI details for Yap1) :1 Gene Ontology (GO) molecular function term (links to tree view) :
About this table
Pathways & Interactions for YAP1
(Pathways according to Invitrogen
(maps by GeneGo ),
Millipore ,
Cell Signaling Technology ,
Sigma-Aldrich ,
KEGG
and/or UniProtKB ,
Sets of similar genes according to GeneDecks ,
Proteins Network according to
SABiosciences ,
Interactions according to 1 UniProtKB ,
2 MINT , and/or
3 STRING ,
with links to IntAct and
Ensembl ,
Ontologies according to Gene Ontology Consortium 01 Apr 2009 via
Entrez Gene .)
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1 Sigma-Aldrich "Your Favorite Gene" Pathway for YAP1 (Your Favorite Gene powered by Ingenuity) Gene Network CentralTM Interacting Genes and Proteins Network for YAP1 5/30 Interacting proteins for YAP1 (P46937 2 ENSP00000282441 3 ) via UniProtKB, MINT, and/or STRING (see all 30
)About this table
Drugs & Compounds for YAP1 (Chemical Compounds according to UniProtKB , Enzo Life Sciences ,
Sigma-Aldrich , Tocris Bioscience , and/or
Novoseek and Drugs according to
Enzo Life Sciences and/or
PharmGKB )
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Browse Tocris compounds for YAP1 2 Novoseek chemical compound relationships for YAP1 gene
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Transcripts for YAP1(GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 219 Homo sapiens; Jun 2 2009) or GenBank , RefSeq according to Entrez Gene ,
DOTS (version 10), and/or
AceView ,
non coding RNAs according to
RNAdb ,
ESTs according to GeneTide ,
exon structure from GeneLoc ,
alternative splicing isoforms according to ASD and/or
ECgene ,
RNAi Products from Invitrogen ,
Millipore , and/or
Abnova ,
siRNAs from Applied Biosystems ,
Sigma-Aldrich ,
shRNA from
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OriGene ,
Tagged/untagged cDNA clones from
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               OriGene 29mer shRNA kit in GFP-retroviral vectors (see all 2 ): NM_001130145 Sigma-Aldrich siRNA for YAP1 Sigma-Aldrich shRNA for YAP1 Explore Sigma-Aldrich super-pooled esiRNAs
Applied Biosystems Silencer ® siRNAs: NM_001130145 NM_006106
REFSEQ mRNAs for YAP1 gene (2 alternative transcripts): NM_001130145.1 NM_006106.3
Applied Biosystems TaqMan ® Gene Expression Assays: NM_001130145 NM_006106
               OriGene GFP tagged cDNA clones in CMV expression vector (see all 2 ): NM_001130145                                  Myc/DDK tagged cDNA clones in CMV expression vector (see all 2 ): NM_001130145                                  untagged cDNA clones in CMV expression vector (see all 2 ): NM_001130145  
Additional cDNA sequence: AK300414.1 AK304485.1 AK310620.1 AK316116.1 AL832620.2 AY316529.1 BC026212.2 BC038235.1 CR618214.1
15 DOTS entries : DT.100824242 DT.446373 DT.91673001 DT.91745842 DT.100043384 DT.101979534 DT.120701800 DT.100824244 DT.307255 DT.120701753 DT.120701732 DT.212517 DT.92436111 DT.100710900 DT.120701734
24/292 AceView cDNA sequences (see all 292
):AI184829 AA460703 AI827322 BI966208 AI281049 BU619886 AI963820 AA872173 AL832620 BM825245 AA948114 AI561312 CK904065 AI911652 BC038235 AW058495 AI598122 AW081855 BU682055 AI590105 AA182461 AA917078 AA181566 AL036707
highest scoring ESTs for YAP1 :AL048399 AA029669 AA091179 AA181566 AA182461 AA186831 AA313079 AA345313 AA346756 AA430595
Unigene Cluster for YAP1: Yes-associated protein 1, 65kDa Hs.503692 [show with all ESTs ] Unigene Representative Sequence: NM_001130145 GeneLoc Exon Structure 5/7 Alternative Splicing Database (ASD) splice patterns (SP) for YAP1 (see all 7
) ExUns: 1a · 1b ^ 2 ^ 3a · 3b ^ 4 ^ 5 ^ 6a · 6b ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12a · 12b · 12c · 12d · 12e · 12f SP1 :     -                 -     -                 SP2 :     -               -   -     -                 SP3 :                     -     -                 SP4 :             -       -   -     -                 SP5 :                                        
About this scheme ECgene alternative splicing isoforms for YAP1 2 Ensembl transcripts including schematic representations : ENST00000345877
ENST00000282441
Expression for YAP1
(Experimental results according to
1 GeneNote
and GNF BioGPS ,
probe sets-to-genes annotations according to
2 GeneAnnot ,
3 GeneTide ,
Sets of similar genes according to GeneDecks ,
Electronic Northern calculations according to data from
UniGene (Build 219 Homo sapiens),
SAGE tags according to
CGAP ,
plus additional links to
SOURCE , and/or
GNF
BioGPS , and/or
EXPOLDB , and/or
UniProtKB ,
Expression Assays from
Applied Biosystems
)
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YAP1 expression in normal and diseased human tissues Applied Biosystems TaqMan ® Gene Expression Assays for YAP1 1 / 2 / 3
8 probe-sets matching YAP1 gene Data from
(Publications) and GNF BioGPS About these images About these images CGAP SAGE TAG: CTCATATGTTSOURCE GeneReport for Unigene cluster: Hs.503692 Expression variation in blood from EXPOLDB for YAP1
Orthologs for YAP1
(Orthologs according to
1,2 HomoloGene (2 older version, for species not in 1 newer version),
3 euGenes ,
4 SGD
and/or
5 MGI Jun 06 2009,
with possible further links to
Flybase
and/or
WormBase ,
Gene Trees according to Ensembl )
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Orthologs for YAP1 gene from 5/8 species (see all 8
)
About this table Species with no ortholog for YAP1 ENSEMBL Gene Tree for YAP1 Paralogs for YAP1 (Paralogs according to 1 HomoloGene and 2 Ensembl , Pseudogenes according to 3 Pseudogene.org )About This Section
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Paralogs for YAP1 gene WWTR1 2
SNPs/Variants for YAP1 (According to the
1 NCBI SNP Database ,
2 Ensembl ,
3 PupaSUITE , and
UniProtKB ,
Linkage Disequilibrium by HapMap ,
Genotyping Reagents from
Applied Biosystems )
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HapMap Linkage Disequilibrium images for YAP1 (up to first 250kb)
Disorders & Mutations for YAP1
(in which this Gene is Involved, According to
OMIM, UniProtKB ,
Novoseek , PharmGKB ,
Genatlas , GeneTests ,
Blood group antigen gene mutations by BGMUT ,
HGMD, GAD ,
HuGE Navigator ,
BCGD ,
and/or TGDB .)
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OMIM: 606608 2 Novoseek disease relationships for YAP1 gene
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Medical News for YAP1 (Possibly Related Articles in
Doctor's Guide )
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--
Publications for YAP1 (in
PubMed .
Associations of this gene to articles via
1 Novoseek ,
2 HGNC ,
3 Entrez Gene ,
4 UniProtKB/Swiss-Prot ,
5 UniProtKB/TrEMBL ,
6 GAD , and/or
7 PharmGKB )
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10/76 PubMed articles for YAP1 gene (see all 76
): Characterization of the mammalian YAP (Yes-associated protein) gene and its role in defining a novel protein module, the WW domain. (PubMed id 7782338) 1, 2, 3, 4 Sudol M.... Lehman D. (1995) A probability-based approach for high-throughput protein phosphorylation analysis and site localization. (PubMed id 16964243) 3, 4 Beausoleil S.A.... Gygi S.P. (2006) Global, in vivo, and site-specific phosphorylation dynamics in signaling networks. (PubMed id 17081983) 3, 4 Olsen J.V....Mann M. (2006) Large-scale characterization of HeLa cell nuclear phosphoproteins. (PubMed id 15302935) 3, 4 Beausoleil S.A....Gygi S.P. (2004) Solution structures of the YAP65 WW domain and the variant L30 K in complex with the peptides GTPPPPYTVG, N-(n-octyl)-GPPPY and PLPPY and the application of peptide libraries reveal a minimal binding epitope. (PubMed id 11743730) 3, 4 Pires J.R.... Oschkinat H. (2001) Characterization of the WW domain of human Yes-associated protein and its polyproline containing ligands. (PubMed id 9202023) 3, 4 Chen H.I.... Sudol M. (1997) Yes-associated protein (YAP65) in relation to Smad7 expression in human pancreatic ductal adenocarcinoma. (PubMed id 16596258) 1, 3 Guo J....Friess H. (2006) YAP1 is involved in mesothelioma development and negatively regulated by Merlin through phosphorylation. (PubMed id 18725387) 1, 3 Yokoyama T....Sekido Y. (2008) Heterogeneous nuclear ribonuclear protein U associates with YAP and regulates its co-activation of Bax transcription. (PubMed id 15096513) 1, 3 Howell M....Milgram S.L. (2004) YAP1 increases organ size and expands undifferentiated progenitor cells. (PubMed id 17980593) 1, 3 Camargo F.D....Brummelkamp T.R. (2007)
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Genome Databases showing YAP1
(According to
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miRBase ,
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and/or
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Other Databases showing YAP1
(According to HUGE )
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Specialized Databases showing YAP1 (According to ATLAS , HORDE , IMGT , MTDB, LEIDEN , UniProtKB/Swiss-Prot , and/or UniProtKB/TrEMBL ,Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot )About This Section
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-- Services for YAP1 (Reagents available from Applied Biosystems , Antibodies and assays by Cell
Signaling Technology , Abcam , Novus Biologicals ,Sigma-Aldrich , R&D Systems , Millipore , Abnova , and/or Invitrogen , Clones available from OriGene ,and/or Invitrogen , Drugs and/or compounds by Sigma-Aldrich , Enzo Life Sciences , and/or Tocris Bioscience )About This Section
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Products for YAP1:
Antibodies & Assays for YAP1   (YAP)
Recombinant Proteins (YAP1 ) Antibodies (YAP1 )
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