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YAP1 Gene

protein-coding   GIFtS: 59

GC11P101486
Yes-associated protein 1, 65kDa
(Previous names: Yes-associated protein 1, 65 kDa )
Symbol approved by the HUGO Gene Nomenclature Committee (HGNC) database
Services    
(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc , and/or 7Ensembl, 8miRBase)
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Aliases
YAP 2
YAP2 2
YAP65 1, 2, 3
YKI 2
Descriptions
Yes-associated protein 1, 65 kDa 1
Yes-associated protein 1, 65kDa 2
yes-associated protein 2 2
External Ids
HGNC: 162621
Entrez Gene: 104132
UniProtKB: P469373
Ensembl: ENSG000001376937
Search outside databases for aliases for YAP1 gene

Previous GC identifers: GC11P104175 GC11P103338 GC11P102015 GC11P101519

(According to Entrez Gene, Wikipedia's Gene Wiki,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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EntrezGene summary for YAP1:
This gene encodes the human ortholog of chicken YAP protein which binds to the SH3 domain of the
Yes proto-oncogene product. This protein contains a WW domain that is found in various structural,
regulatory and signaling molecules in yeast, nematode, and mammals, and may be involved in
protein-protein interaction. [provided by RefSeq]

Gene Wiki entry for YAP1
(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 36),
and/or miRBase,
Genomic Views according to UCSC and Ensembl, Transcription factor binding sites according to SABiosciences)
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Genomic View:
UCSC Golden Path with GeneCards custom track

 Transcription factor binding sites upstream to the YAP1 gene  

Entrez Gene cytogenetic band: 11q13   Ensembl cytogenetic band:  11q22.1   HGNC cytogenetic band: 11q13

YAP1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)

GeneLoc gene densities for chromosome 11         GeneLoc Exon Structure

GeneLoc location for GC11P101486:     (about GC identifiers)

Start:
101,486,497 bp from pter
End:
101,609,359 bp from pter
Size:
122,863 bases
Orientation:
plus strand
RefSeq DNA sequence:
NC_000011.8  NT_033899.7  
(According to 1UniProtKB, and/or Ensembl, Phosphorylation sites according to 2Phosphosite, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Enzo Life Sciences, Abnova, OriGene and/or, Abcam,
Biochemical Assays by Invitrogen, Millipore, R&D Systems, Cell Signaling Technology, and/or Enzo Life Sciences, Ontologies according to Gene Ontology Consortium 01 Apr 2009 and Entrez Gene, Antibodies by Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Cell Signaling Technology, Abcam, Abnova, and/or Novus Biologicals)
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UniProtKB/Swiss-Prot: YAP1_HUMAN, P46937 (See protein sequence)
Recommended Name: 65 kDa Yes-associated protein  
Size: 454 amino acids; 48755 Da
Subunit: Binds to the SH3 domain of the YES kinase. Binds to WBP1 and WBP2. Binds, in vitro,
through the WW1 domain, to neural isoforms of ENAH that contain the PPSY motif (By similarity)
PDB structures from and Proteopedia :
1JMQ (3D)    1K5R (3D)    1K9Q (3D)    1K9R (3D)    

Post-translational modifications:

  • Phosphorylated upon DNA damage, probably by ATM or ATR1
  • View phosphorylation sites using PhosphoSite2


  • REFSEQ proteins (2 alternative transcripts): 
    NP_001123617.1  NP_006097.1  


    ENSEMBL proteins: 
    ENSP00000331023 ENSP00000282441 


    Human Recombinant Proteins 
    Browse Drug Discovery Central at Invitrogen for human recombinant proteins
    Browse Purified and Recombinant Proteins at Millipore
    Browse Human Recombinant Proteins at Sigma-Aldrich  
    Browse R&D Systems for human recombinant proteins
    Browse recombinant and purified proteins available from Enzo Life Sciences
    Recombinant Proteins from Abcam (YAP1)
    Human Recombinant Proteins from Abnova (YAP1)
                  OriGene Purified Recombinant Human Protein: YAP1 


    Antibodies for YAP1: 
    Browse Antibodies Central at Invitrogen
    Browse Millipore's Extensive Line of Mono- and Polyclonal Antibodies
    Sigma-Aldrich Antibodies for YAP1
    Browse R&D Systems for Antibodies
    Cell Signaling Technology (CST) Antibodies for YAP1  (YAP)
    Antibodies from Abcam (YAP1), each with their AbpromiseSM
    Monoclonal and Polyclonal Antibodies from Abnova (YAP1)
    Novus Biologicals Antibodies for YAP1

    Assays for YAP1: 
    Browse Invitrogen for biochemical assays
    Browse Kits and Assays available from Millipore
    Browse R&D Systems for biochemical assays
    Browse biochemical assays available from Enzo Life Sciences

    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section

    1 InterPro domain/family:
     IPR001202 WW_Rsp5_WWP


       GeneDecks  YAP1 for the domains selected above  
    About GeneDecksing

    Graphical View of Domain Structure for InterPro Entry P46937

    ProtoNet protein and cluster: P46937

    1 Blocks protein family: IPB002349 WW domain signature

    UniProtKB/Swiss-Prot: YAP1_HUMAN, P46937
    Similarity: Contains 1 WW domain

    (According to MGI Jun 06 2009, UniProtKB, IUBMB,and/or Genatlas,
    shRNA from OriGene, Sigma-Aldrich, RNAi from Sigma-Aldrich,
    RNAi Products, Clones, and Q-PCR Products from Invitrogen, Millipore, OriGene, and/or Abnova, siRNAs from Applied Biosystems, SYBR primers from OriGene, Cell-based Assays from Millipore, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
    About This Section

    Inhib.
    RNA:
    Invitrogen RNAi Products for gene knock-down (YAP1)
    Browse for Gene Knock-down Tools from Millipore
    Abnova Chimera RNAi Products for Gene knock-down (YAP1)
                   OriGene 29mer shRNA kit in GFP-retroviral vectors (see all 2): NM_001130145

                  Applied Biosystems Silencer® siRNAs for YAP1

                  Sigma-Aldrich siRNA for YAP1  
                         Sigma-Aldrich shRNA for YAP1  
                         Explore Sigma-Aldrich super-pooled esiRNAs  

    Clones:Invitrogen Clones for YAP1
    Browse Clones for the Expression of Recombinant Proteins Available from Millipore
                   OriGene GFP tagged cDNA clones in CMV expression vector (see all 2): NM_001130145
                                     Myc/DDK tagged cDNA clones in CMV expression vector (see all 2): NM_001130145
                                     untagged cDNA clones in CMV expression vector (see all 2): NM_001130145 

    Primers: Browse Quantitative PCR Central at Invitrogen for Q-PCR LUX™ Primers
                  OriGene genome-wide validated SYBR primer pairs: NM_001130145

    5 MGI mutant phenotypes (inferred from 1 allele(MGI details for Yap1):

    embryogenesisgrowth/sizelethality-prenatal/perinatalnervous system

    1 Gene Ontology (GO) molecular function term (links to tree view):

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005515 protein binding IPI7644498
    About this table

    (Pathways according to Invitrogen (maps by GeneGo), Millipore, Cell Signaling Technology, Sigma-Aldrich, KEGG and/or UniProtKB,
    Sets of similar genes according to GeneDecks, Proteins Network according to SABiosciences, Interactions according to 1UniProtKB, 2MINT, and/or 3STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
    About This Section


    1 Sigma-Aldrich "Your Favorite Gene" Pathway for  YAP1  (Your Favorite Gene powered by Ingenuity) 
     14-3-3-mediated Signaling

       GeneDecks  YAP1 for the pathways selected above  
    About GeneDecksing

    1 Cell Signaling Technology (CST) Pathway for YAP1: 
     Akt/PKB Signaling

       GeneDecks  YAP1 for the pathways selected above  
    About GeneDecksing

     Gene Network CentralTM Interacting Genes and Proteins Network for  YAP1 


    5/30 Interacting proteins for YAP1 (P469372 ENSP000002824413) via UniProtKB, MINT, and/or STRING (see all 30 )
    InteractantInteraction Details
    GeneCardExternal ID(s)
    SLC9A3R1O147452, ENSP000002626133MINT-72738 MINT-72744 MINT-72745 MINT-72736 MINT-72741 MINT-72740 MINT-72743 MINT-72747 STRING (score=.767)
    TP73O153502MINT-3388748 MINT-3388922 MINT-3388949 MINT-3388697 MINT-3388978 MINT-3388723 MINT-3388775
    MED28Q9H2042MINT-7041969
    SLC9A3R2Q155992MINT-68603
    TP63Q9H3D42MINT-3388996
    About this table
    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, Sigma-Aldrich, Tocris Bioscience, and/or Novoseek and Drugs according to Enzo Life Sciences and/or PharmGKB)
    About This Section

    Browse drugs & compounds from Enzo Life Sciences
    Browse Small Molecules at Sigma-Aldrich

    Browse Tocris compounds for YAP1
    2 Novoseek chemical compound relationships for YAP1 gene
    Compound   Score   Articles   PubMed IDs for Articles with Shared Sentences (# sentences)
    tyrosine 20.27 5 14765127 (2), 11278685 (1), 16061658 (1)
    proline 17.07 2 8035999 (2)
    About this table


    (GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 219 Homo sapiens; Jun 2 2009) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView,
    non coding RNAs according to RNAdb,
    ESTs according to GeneTide,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from Invitrogen, Millipore, and/or Abnova,
    siRNAs from Applied Biosystems, Sigma-Aldrich,
    shRNA from Sigma-Aldrich, OriGene,
    Tagged/untagged cDNA clones from OriGene,
    Expression Assays from Applied Biosystems)
    About This Section

    Inhib.
    RNA:
    Invitrogen RNAi Products for gene knock-down (YAP1)
    Browse for Gene Knock-down Tools from Millipore
    Abnova Chimera RNAi Products for Gene knock-down (YAP1)
                   OriGene 29mer shRNA kit in GFP-retroviral vectors (see all 2): NM_001130145

                  Sigma-Aldrich siRNA for YAP1  
                         Sigma-Aldrich shRNA for YAP1  
                         Explore Sigma-Aldrich super-pooled esiRNAs  

    Applied Biosystems Silencer® siRNAs: 

    NM_001130145  NM_006106  

    REFSEQ mRNAs for YAP1 gene (2 alternative transcripts): 

    NM_001130145.1   NM_006106.3   

    Applied Biosystems TaqMan ® Gene Expression Assays: 

    NM_001130145  NM_006106  

                   OriGene GFP tagged cDNA clones in CMV expression vector (see all 2): NM_001130145
                                     Myc/DDK tagged cDNA clones in CMV expression vector (see all 2): NM_001130145
                                     untagged cDNA clones in CMV expression vector (see all 2): NM_001130145 

    Additional cDNA sequence: 

    AK300414.1 AK304485.1 AK310620.1 AK316116.1 AL832620.2 AY316529.1 BC026212.2 BC038235.1 
    CR618214.1 

    15 DOTS entries:

    DT.100824242  DT.446373  DT.91673001  DT.91745842  DT.100043384  DT.101979534  DT.120701800  DT.100824244 
    DT.307255  DT.120701753  DT.120701732  DT.212517  DT.92436111  DT.100710900  DT.120701734 

    24/292 AceView cDNA sequences (see all 292 ):

    AI184829 AA460703 AI827322 BI966208 AI281049 BU619886 AI963820 AA872173 
    AL832620 BM825245 AA948114 AI561312 CK904065 AI911652 BC038235 AW058495 
    AI598122 AW081855 BU682055 AI590105 AA182461 AA917078 AA181566 AL036707 

    highest scoring ESTs for YAP1:

    AL048399 AA029669 AA091179 AA181566 AA182461 AA186831 AA313079 AA345313 AA346756 AA430595 

    Unigene Cluster for YAP1:

    Yes-associated protein 1, 65kDa
    Hs.503692  [show with all ESTs]
    Unigene Representative Sequence: NM_001130145


    GeneLoc Exon Structure

    5/7 Alternative Splicing Database (ASD) splice patterns (SP) for YAP1 (see all 7 )

    ExUns: 1a · 1b ^ 2 ^ 3a · 3b ^ 4 ^ 5 ^ 6a · 6b ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12a · 12b · 12c · 12d · 12e · 12f
    SP1:              -                                               -           -                                             
    SP2:              -                                         -     -           -                                             
    SP3:                                                              -           -                                             
    SP4:                                      -                 -     -           -                                             
    SP5:                                                                                                                        

    About this scheme

    ECgene alternative splicing isoforms for YAP1

    2 Ensembl transcripts including schematic representations:
    ENST00000345877  ENST00000282441  
    (Experimental results according to 1GeneNote and GNF BioGPS,
    probe sets-to-genes annotations according to 2GeneAnnot , 3GeneTide , Sets of similar genes according to GeneDecks, Electronic Northern calculations according to data from UniGene (Build 219 Homo sapiens), SAGE tags according to CGAP, plus additional links to SOURCE, and/or GNF BioGPS, and/or EXPOLDB, and/or UniProtKB,
    Expression Assays from Applied Biosystems )
    About This Section

    YAP1 expression in normal and diseased human tissues

     Applied Biosystems TaqMan ® Gene Expression Assays for YAP1

    1 / 2 / 3

    8 probe-sets matching YAP1 gene


    Affymetrix
    probe-set
    Array  GeneAnnot data GeneNote data GeneTide data
    # genes Sensitivity Specificity Correlation Length Gb_Accession Consensus Uniqueness Score Rank

    37979_at2, 3 U95-A 1 1.00 1.00 0.97 0.61 X80507 0.20 1.00 0.72 1
    46314_at2, 3 U95-B 1 0.94 1.00 0.95 1.40 AL048399 1.00 1.00 1.00 1

    224895_at2, 3 U133-B 1 1.00 1.00 -- -- AA557632 0.80 1.00 0.91 1

    224894_at2, 3 U133-B 1 1.00 1.00 -- -- BF247906 0.80 1.00 0.91 1

    213342_at2, 3 U133-A 1 1.00 1.00 -- -- AI745185 0.80 1.00 0.91 1

    224895_at2 U133Plus2 1 1.00 1.00 -- -- -- -- -- -- --

    224894_at2 U133Plus2 1 1.00 1.00 -- -- -- -- -- -- --

    213342_at2 U133Plus2 1 1.00 1.00 -- -- -- -- -- -- --
    GeneDecks  YAP1 for binary patterns associated with the probe-sets selected above  
    About GeneDecksing
    About this table    
    Data from (Publications) and GNF BioGPS
        About these images
    About these images

    CGAP SAGE TAG: CTCATATGTT

    SOURCE GeneReport for Unigene cluster: Hs.503692

    Expression variation in blood from EXPOLDB for YAP1

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD and/or 5MGI Jun 06 2009, with possible further links to Flybase and/or WormBase, Gene Trees according to Ensembl)
    About This Section


    Orthologs for YAP1 gene from 5/8 species (see all 8 )
    Organism Gene Locus Description Human
    Similarity
    NCBI accessions
    dog
    (Canis familiaris)
    YAP11   -- Yes-associated protein 1, 65kDa 86.5(n)
    93.2(a)
    479465  XM_536601.2  XP_536601.2 
    chimpanzee
    (Pan troglodytes)
    YAP11   -- Yes-associated protein 1, 65kDa 99.34(n)
    99.34(a)
    451506  XM_001151467.1  XP_001151467.1 
    cow
    (Bos taurus)
    LOC7873601   -- similar to 65 kDa Yes-associated protein (YAP65) 91.41(n)
    98.22(a)
    787360  XM_001254780.1  XP_001254781.1 
    mouse
    (Mus musculus)
    Yap11, 5 95
    yes-associated protein 11, 5 80.64(n)1
    80.64(a)1
    226011  NM_009534.21  NP_033560.11 
     AI3252075  AK1605435  (see all 14)
    chicken
    (Gallus gallus)
    YAP11   -- Yes-associated protein 1, 65kDa 82.22(n)
    89.06(a)
    396171  NM_205243.1  NP_990574.1 
    About this table        Species with no ortholog for YAP1

    ENSEMBL Gene Tree for YAP1
    (Paralogs according to 1HomoloGene
    and 2Ensembl, Pseudogenes according to 3Pseudogene.org)
    About This Section

    Paralogs for YAP1 gene
    WWTR12  

    (According to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, and UniProtKB, Linkage Disequilibrium by HapMap, Genotyping Reagents from Applied Biosystems)
    About This Section


    10/647 NCBI SNPs in YAP1 are shown (see all 647 )
    (Click for Applied Biosystems TaqMan ® Genotyping Assay)  (see all 194)
    ABGenomic DataTranscription DataAllele Frequencies
    SNP IDValidChr 11 posSequenceRecsAA
    Chg
    TypeMoreRecsAllele
    freq
    PopTotal
    sample
    More
    ------------
    --
    rs85041,2
    A,C,F,H,O101608810(+) TAAATG/ATAGTG 2 -- ut319Minor allele frequency- A:0.44EA MN NA EU WA 2218
    rs18204531,2
    A,C,F,H,O101485545(-) AGTGCT/GTCTTC 1 -- ng516Minor allele frequency- G:0.26MN EU EA WA 2100
    --
    rs112251741,2
    A,C,F,H101607156(+) TGGAAT/ATCAGT 2 -- ut31 ese37Minor allele frequency- A:0.38NA EU EA WA 552
    rs37526851,2
    A,C,F101485788(-) TAAAGG/ATCCAT 1 -- ng51 tfbs35Minor allele frequency- A:0.26EA NA 1862
    --
    rs79318991,2
    A,C101484582(+) GTGAAC/TATGGG 1 -- ng510--------
    rs127988271,2
    F,H101609454(+) TAAAAG/AGTGAT 1 -- ng314Minor allele frequency- A:0.01EU EA WA 420
    rs150671,2
    F101606327(-) GACCAG/TTAAAT 2 -- ut31 ese31Minor allele frequency- T:0.01MN 184
    --
    rs71063881,2
    A101486487(+) cgaGCC/TGTCCG 2 -- ut510--------
    rs28468381,2
    H101609433(-) TTGTTC/TTATTG 1 -- ng314Minor allele frequency- T:0.00EU EA WA 418
    rs9487371,2
    A,C,F,H,O101534039(-) AAATCG/ATTTGT 1 -- int122Minor allele frequency- A:0.42EA NA NS EU WA 1430
    About this table

    HapMap Linkage Disequilibrium images for YAP1 (up to first 250kb)

    (in which this Gene is Involved, According to OMIM, UniProtKB, Novoseek, PharmGKB, Genatlas, GeneTests, Blood group antigen gene mutations by BGMUT, HGMD, GAD, HuGE Navigator, BCGD, and/or TGDB.)
    About This Section

    OMIM: 606608

    2 Novoseek disease relationships for YAP1 gene

    Disease   Score   Articles   PubMed IDs for Articles with Shared Sentences (# sentences)
    tumors 22.61 7 9224934 (1), 17889659 (1), 19111660 (1), 19234525 (1) (see all 6)
    cancer 11.91 5 16596258 (3), 18953429 (1), 17974916 (1)
    About this table

    (Possibly Related Articles in Doctor's Guide)
    About This Section

      --

    (in PubMed. Associations of this gene to articles via 1Novoseek, 2HGNC, 3Entrez Gene, 4UniProtKB/Swiss-Prot, 5UniProtKB/TrEMBL, 6GAD, and/or 7PharmGKB)
    About This Section

    10/76 PubMed articles for YAP1 gene (see all 76 ):
    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section

     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)
    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, and/or H-InvDB)
    About This Section

    Entrez Gene: 10413 HGNC: 16262 AceView: YAP1 Ensembl:ENSG00000137693 euGenes: HUgn10413
    ECgene: YAP1 H-InvDB: YAP1
    (According to HUGE)
    About This Section

      --
    (According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section

    NameDescription
    ATLAS Chromosomes in Cancer entry for YAP1 Genetics and Cytogenetics in Oncology and Haematology
    (Available from WIS Yeda, Salk, Tufts)
    About This Section

      --
    (Reagents available from Applied Biosystems, Antibodies and assays by Cell Signaling Technology, Abcam, Novus Biologicals,
    Sigma-Aldrich, R&D Systems, Millipore, Abnova, and/or Invitrogen, Clones available from OriGene,and/or Invitrogen, Drugs and/or compounds by Sigma-Aldrich,
    Enzo Life Sciences, and/or Tocris Bioscience)
    About This Section



    Products for YAP1:
     TaqMan ® Gene Expression Assays
     TaqMan ® Genotyping Assays
      Free SNP selection tool



      Invitrogen iPath Pathways  Invitrogen BLOCK-iT™ RNAi
      Invitrogen Antibodies  Invitrogen Assays
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     Predesigned and custom siRNAs for YAP1 Antibodies for YAP1
     Explore super-pooled esiRNAs Browse proteins at Sigma-Aldrich
     Lentivirus-delivered shRNAs for YAP1 Browse small molecules at Sigma-Aldrich
     "Your Favorite Gene" Pathwaysfeedback


      
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     Recombinant & Natural Proteins  

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     Antibodies & Assays for YAP1  (YAP)

     Recombinant Proteins
    (YAP1)
     Antibodies (YAP1)
     Tagged/untagged cDNA clones
     Validated SYBR primer pairs
     Purified proteins from HEK293T cells
     Western blot validated antibodies
     shRNA in GFP-retroviral vector
     Search Tocris compounds for YAP1




     Search www.enzolifesicences.com for proteins, assays, substrates, inhibitors & antibodies
     Antibodies for YAP1

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