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Aliases for YAP1 Gene

Aliases for YAP1 Gene

  • Yes-Associated Protein 1 2 3 4
  • Yes-Associated Protein YAP65 Homolog 3 4
  • Protein Yorkie Homolog 3 4
  • YAP65 3 4
  • Transcriptional Coactivator YAP1 3
  • Yes-Associated Protein 1, 65kDa 2
  • 65 KDa Yes-Associated Protein 3
  • Yes-Associated Protein 2 3
  • Yorkie Homolog 3
  • COB1 3
  • YAP2 3
  • YAP 3
  • YKI 3

External Ids for YAP1 Gene

Previous GeneCards Identifiers for YAP1 Gene

  • GC11P104175
  • GC11P103338
  • GC11P102015
  • GC11P101519
  • GC11P101486
  • GC11P097907

Summaries for YAP1 Gene

Entrez Gene Summary for YAP1 Gene

  • This gene encodes a downstream nuclear effector of the Hippo signaling pathway which is involved in development, growth, repair, and homeostasis. This gene is known to play a role in the development and progression of multiple cancers as a transcriptional regulator of this signaling pathway and may function as a potential target for cancer treatment. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Aug 2013]

GeneCards Summary for YAP1 Gene

YAP1 (Yes-Associated Protein 1) is a Protein Coding gene. Diseases associated with YAP1 include coloboma, ocular, with or without hearing impairment, cleft lip/palate, and/or mental retardation and uveal coloboma - cleft lip and palate - intellectual disability. Among its related pathways are PI-3K cascade and Signaling by GPCR. GO annotations related to this gene include chromatin binding and transcription corepressor activity. An important paralog of this gene is WWTR1.

UniProtKB/Swiss-Prot for YAP1 Gene

  • Transcriptional regulator which can act both as a coactivator and a corepressor and is the critical downstream regulatory target in the Hippo signaling pathway that plays a pivotal role in organ size control and tumor suppression by restricting proliferation and promoting apoptosis. The core of this pathway is composed of a kinase cascade wherein STK3/MST2 and STK4/MST1, in complex with its regulatory protein SAV1, phosphorylates and activates LATS1/2 in complex with its regulatory protein MOB1, which in turn phosphorylates and inactivates YAP1 oncoprotein and WWTR1/TAZ. Plays a key role to control cell proliferation in response to cell contact. Phosphorylation of YAP1 by LATS1/2 inhibits its translocation into the nucleus to regulate cellular genes important for cell proliferation, cell death, and cell migration. The presence of TEAD transcription factors are required for it to stimulate gene expression, cell growth, anchorage-independent growth, and epithelial mesenchymal transition (EMT) induction. Isoform 2 and isoform 3 can activate the C-terminal fragment (CTF) of ERBB4 (isoform 3).

Gene Wiki entry for YAP1 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for YAP1 Gene

Genomics for YAP1 Gene

Regulatory Elements for YAP1 Gene

Genomic Location for YAP1 Gene

Start:
102,110,420 bp from pter
End:
102,233,423 bp from pter
Size:
123,004 bases
Orientation:
Plus strand

Genomic View for YAP1 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for YAP1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for YAP1 Gene

Proteins for YAP1 Gene

  • Protein details for YAP1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P46937-YAP1_HUMAN
    Recommended name:
    Transcriptional coactivator YAP1
    Protein Accession:
    P46937
    Secondary Accessions:
    • B4DTY1
    • B7ZA01
    • E3WEB5
    • E3WEB6
    • E9PRV2
    • F5H202
    • K0KQ18
    • K0KYZ8
    • K0L195
    • K0L1G3
    • Q7Z574
    • Q8IUY9

    Protein attributes for YAP1 Gene

    Size:
    504 amino acids
    Molecular mass:
    54462 Da
    Quaternary structure:
    • Binds to the SH3 domain of the YES kinase. Binds to WBP1 and WBP2. Binds, in vitro, through the WW1 domain, to neural isoforms of ENAH that contain the PPSY motif (By similarity). The phosphorylated form interacts with YWHAB. Interacts (via WW domains) with LATS1 (via PPxY motif 2). Interacts with LATS2. Isoform 2 and isoform 3 interact (via WW domain 1) with isoform 3 of ERBB4 (via PPxY motif 2). Interacts with TEAD1, TEAD2, TEAD3 and TEAD4. Interacts with TP73. Interacts with RUNX1. Interacts with HCK. Interacts (via WW domains) with PTPN14 (via PPxY motif 2); this interaction leads to the cytoplasmic sequestration of YAP1 and inhibits its transcriptional coactivator activity.

    Three dimensional structures from OCA and Proteopedia for YAP1 Gene

    Alternative splice isoforms for YAP1 Gene

neXtProt entry for YAP1 Gene

Proteomics data for YAP1 Gene at MOPED

Post-translational modifications for YAP1 Gene

  • Phosphorylated by LATS1 and LATS2; leading to cytoplasmic translocation and inactivation. Phosphorylated by ABL1; leading to YAP1 stabilization, enhanced interaction with TP73 and recruitment onto proapoptotic genes; in response to DNA damage. Phosphorylation at Ser-400 and Ser-403 by CK1 is triggered by previous phosphorylation at Ser-397 by LATS proteins and leads to YAP1 ubiquitination by SCF(beta-TRCP) E3 ubiquitin ligase and subsequent degradation. Phosphorylated at Thr-119, Ser-138, Thr-154, Ser-367 and Thr-412 by MAPK8/JNK1 and MAPK9/JNK2, which is required for the regukation of apoptosis by YAP1.
  • Ubiquitinated by SCF(beta-TRCP) E3 ubiquitin ligase.
  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for YAP1 Gene

Domains for YAP1 Gene

Protein Domains for YAP1 Gene

InterPro:
Blocks:
ProtoNet:

Suggested Antigen Peptide Sequences for YAP1 Gene

Graphical View of Domain Structure for InterPro Entry

P46937

UniProtKB/Swiss-Prot:

YAP1_HUMAN :
  • P46937
Domain:
  • The first coiled-coil region mediates most of the interaction with TEAD transcription factors
  • Contains 2 WW domains.
Family:
  • Belongs to the YAP1 family.
genes like me logo Genes that share domains with YAP1: view

No data available for Gene Families for YAP1 Gene

Function for YAP1 Gene

Molecular function for YAP1 Gene

UniProtKB/Swiss-Prot Function: Transcriptional regulator which can act both as a coactivator and a corepressor and is the critical downstream regulatory target in the Hippo signaling pathway that plays a pivotal role in organ size control and tumor suppression by restricting proliferation and promoting apoptosis. The core of this pathway is composed of a kinase cascade wherein STK3/MST2 and STK4/MST1, in complex with its regulatory protein SAV1, phosphorylates and activates LATS1/2 in complex with its regulatory protein MOB1, which in turn phosphorylates and inactivates YAP1 oncoprotein and WWTR1/TAZ. Plays a key role to control cell proliferation in response to cell contact. Phosphorylation of YAP1 by LATS1/2 inhibits its translocation into the nucleus to regulate cellular genes important for cell proliferation, cell death, and cell migration. The presence of TEAD transcription factors are required for it to stimulate gene expression, cell growth, anchorage-independent growth, and epithelial mesenchymal transition (EMT) induction. Isoform 2 and isoform 3 can activate the C-terminal fragment (CTF) of ERBB4 (isoform 3).

Gene Ontology (GO) - Molecular Function for YAP1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000979 RNA polymerase II core promoter sequence-specific DNA binding IEA --
GO:0001076 RNA polymerase II transcription factor binding transcription factor activity IEA --
GO:0003682 chromatin binding IEA --
GO:0003713 transcription coactivator activity IDA 18158288
GO:0003714 transcription corepressor activity IDA 18158288
genes like me logo Genes that share ontologies with YAP1: view
genes like me logo Genes that share phenotypes with YAP1: view

Animal Models for YAP1 Gene

MGI Knock Outs for YAP1:

miRNA for YAP1 Gene

No data available for Enzyme Numbers (IUBMB) , Transcription Factor Targeting and HOMER Transcription for YAP1 Gene

Localization for YAP1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for YAP1 Gene

Cytoplasm. Nucleus. Note=Both phosphorylation and cell density can regulate its subcellular localization. Phosphorylation sequesters it in the cytoplasm by inhibiting its translocation into the nucleus. At low density, predominantly nuclear and is translocated to the cytoplasm at high density. PTPN14 induces translocation from the nucleus to the cytoplasm.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for YAP1 Gene COMPARTMENTS Subcellular localization image for YAP1 gene
Compartment Confidence
nucleus 5
cytosol 4

Gene Ontology (GO) - Cellular Components for YAP1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IDA 17974916
GO:0005654 nucleoplasm TAS --
GO:0005667 transcription factor complex IEA --
GO:0005737 cytoplasm IDA 17974916
GO:0005829 cytosol TAS --
genes like me logo Genes that share ontologies with YAP1: view

Pathways for YAP1 Gene

genes like me logo Genes that share pathways with YAP1: view

Gene Ontology (GO) - Biological Process for YAP1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000902 cell morphogenesis IEA --
GO:0001570 vasculogenesis IEA --
GO:0003143 embryonic heart tube morphogenesis IEA --
GO:0006366 transcription from RNA polymerase II promoter --
GO:0006367 transcription initiation from RNA polymerase II promoter TAS --
genes like me logo Genes that share ontologies with YAP1: view

Compounds for YAP1 Gene

(3) Novoseek inferred chemical compound relationships for YAP1 Gene

Compound -log(P) Hits PubMed IDs
tyrosine 15.6 4
proline 12.5 2
serine 3.3 2
genes like me logo Genes that share compounds with YAP1: view

Transcripts for YAP1 Gene

Unigene Clusters for YAP1 Gene

Yes-associated protein 1:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for YAP1 Gene

ExUns: 1a · 1b ^ 2 ^ 3a · 3b ^ 4 ^ 5 ^ 6a · 6b ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12a · 12b · 12c · 12d · 12e · 12f
SP1: - - -
SP2: - - - -
SP3: - -
SP4: - - - -
SP5:
SP6: -
SP7:

Relevant External Links for YAP1 Gene

GeneLoc Exon Structure for
YAP1
ECgene alternative splicing isoforms for
YAP1

Expression for YAP1 Gene

mRNA expression in normal human tissues for YAP1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for YAP1 Gene

SOURCE GeneReport for Unigene cluster for YAP1 Gene Hs.503692

mRNA Expression by UniProt/SwissProt for YAP1 Gene

P46937-YAP1_HUMAN
Tissue specificity: Increased expression seen in some liver and prostate cancers. Isoforms lacking the transactivation domain found in striatal neurons of patients with Huntington disease (at protein level).
genes like me logo Genes that share expressions with YAP1: view

No data available for mRNA differential expression in normal tissues for YAP1 Gene

Orthologs for YAP1 Gene

This gene was present in the common ancestor of animals.

Orthologs for YAP1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia YAP1 35
  • 99.86 (n)
  • 100 (a)
YAP1 36
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia -- 36
  • 93 (a)
OneToMany
-- 36
  • 98 (a)
OneToMany
YAP1 35
  • 92.15 (n)
  • 99.03 (a)
dog
(Canis familiaris)
Mammalia YAP1 35
  • 87.34 (n)
  • 92.76 (a)
YAP1 36
  • 95 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Yap1 35
  • 88.71 (n)
  • 93.14 (a)
Yap1 16
Yap1 36
  • 89 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia YAP1 36
  • 93 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia YAP1 36
  • 96 (a)
OneToOne
chicken
(Gallus gallus)
Aves YAP1 35
  • 85.05 (n)
  • 94.49 (a)
YAP1 36
  • 93 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia YAP1 36
  • 86 (a)
OneToOne
African clawed frog
(Xenopus laevis)
Amphibia Xl.7656 35
tropical clawed frog
(Silurana tropicalis)
Amphibia Str.16747 35
yap1 35
  • 76.48 (n)
  • 85.98 (a)
zebrafish
(Danio rerio)
Actinopterygii Dr.12698 35
yap1 35
  • 75.84 (n)
  • 83.76 (a)
yap1 36
  • 79 (a)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta yki 36
  • 23 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea CSA.7043 36
  • 24 (a)
OneToMany
Species with no ortholog for YAP1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for YAP1 Gene

ENSEMBL:
Gene Tree for YAP1 (if available)
TreeFam:
Gene Tree for YAP1 (if available)

Paralogs for YAP1 Gene

Paralogs for YAP1 Gene

Selected SIMAP similar genes for YAP1 Gene using alignment to 3 proteins:

Pseudogenes.org Pseudogenes for YAP1 Gene

genes like me logo Genes that share paralogs with YAP1: view

Variants for YAP1 Gene

Sequence variations from dbSNP and Humsavar for YAP1 Gene

SNP ID Clin Chr 11 pos Sequence Context AA Info Type MAF
rs8504 -- 102,232,869(+) TAAAT(A/G)TAGTG utr-variant-3-prime
rs15067 -- 102,230,386(-) GACCA(G/T)TAAAT utr-variant-3-prime
rs25450 -- 102,224,402(-) ATGAC(C/T)TCCTA intron-variant
rs948736 -- 102,138,607(-) TCCAG(A/G)ATCCA intron-variant
rs948737 -- 102,158,098(-) AAATC(A/G)TTTGT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for YAP1 Gene

Variant ID Type Subtype PubMed ID
nsv898333 CNV Gain 21882294
nsv832251 CNV Loss 17160897
esv2524266 CNV Deletion 19546169

Relevant External Links for YAP1 Gene

HapMap Linkage Disequilibrium report
YAP1
Human Gene Mutation Database (HGMD)
YAP1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for YAP1 Gene

Disorders for YAP1 Gene

(1) OMIM Diseases for YAP1 Gene (606608)

UniProtKB/Swiss-Prot

YAP1_HUMAN
  • Coloboma, ocular, with or without hearing impairment, cleft lip/palate, and/or mental retardation (COB1) [MIM:120433]: An autosomal dominant disease characterized by uveal colobomata, microphthalmia, cataract and cleft lip/palate. Considerable variability is observed among patients, uveal colobomata being the most constant feature. Some patients manifest mental retardation of varying degree and/or sensorineural, mid-frequency hearing loss. {ECO:0000269 PubMed:24462371}. Note=The disease is caused by mutations affecting the gene represented in this entry.

(1) University of Copenhagen DISEASES for YAP1 Gene

(2) Novoseek inferred disease relationships for YAP1 Gene

Disease -log(P) Hits PubMed IDs
tumors 31.6 19
cancer 20.2 10

Relevant External Links for YAP1

Genetic Association Database (GAD)
YAP1
Human Genome Epidemiology (HuGE) Navigator
YAP1
genes like me logo Genes that share disorders with YAP1: view

Publications for YAP1 Gene

  1. Characterization of the mammalian YAP (Yes-associated protein) gene and its role in defining a novel protein module, the WW domain. (PMID: 7782338) Sudol M. … Lehman D. (J. Biol. Chem. 1995) 2 3 4 23
  2. WW domain-containing protein YAP associates with ErbB-4 and acts as a co-transcriptional activator for the carboxyl-terminal fragment of ErbB-4 that translocates to the nucleus. (PMID: 12807903) Komuro A. … Sudol M. (J. Biol. Chem. 2003) 3 4 23
  3. Inactivation of YAP oncoprotein by the Hippo pathway is involved in cell contact inhibition and tissue growth control. (PMID: 17974916) Zhao B. … Guan K.L. (Genes Dev. 2007) 3 4 23
  4. A coordinated phosphorylation by Lats and CK1 regulates YAP stability through SCF(beta-TRCP). (PMID: 20048001) Zhao B. … Guan K.-L. (Genes Dev. 2010) 3 4 23
  5. Structural insights into the YAP and TEAD complex. (PMID: 20123905) Li Z. … Xu Y. (Genes Dev. 2010) 4 23

Products for YAP1 Gene

  • Addgene plasmids for YAP1

Sources for YAP1 Gene

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