YAP1 Gene
protein-coding GIFtS : 65 GCID: GC11 P102015
Yes-associated protein 1 Yes-associated protein 1, 65kDa )
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Aliasesfor YAP1 gene
(According to
1 HGNC ,
2 Entrez Gene ,
3 UniProtKB/Swiss-Prot ,
4 UniProtKB/TrEMBL , 5 OMIM , 6 GeneLoc ,
7 Ensembl ,
8 DME ,
9 miRBase ,
and/or 10 fRNAdb )About This Section Aliases Yes-Associated Protein 1 1 2 YKI2 YAP651 2 3 Yes-Associated Protein 22 65 KDa Yes-Associated Protein2 3 Yes-Associated Protein Beta2 Yes-Associated Protein 1, 65kDa1 Yes-Associated Protein Delta2 YAP2 Yorkie Homolog2 YAP22
Export aliases for YAP1 gene to outside databases Previous GC identifers: GC11P104175 GC11P103338 GC11P101519 GC11P101486 GC11P097907
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Summariesfor YAP1 gene (According to Entrez Gene ,
Tocris Bioscience ,
Wikipedia's
Gene Wiki ,
PharmGKB ,UniProtKB/Swiss-Prot ,
and/or
UniProtKB/TrEMBL )
About This Section Entrez Gene summary for YAP1 : This gene encodes the human ortholog of chicken YAP protein which binds to the SH3 domain of the Yes proto-oncogene product. This protein contains a WW domain that is found in various structural, regulatory and signaling molecules in yeast, nematode, and mammals, and may be involved in protein-protein interaction. (provided by RefSeq, Jul 2008) UniProtKB/Swiss-Prot: YAP1_HUMAN, P46937 Function : Transcriptional regulator which can act both as a coactivator and a corepressor and is the criticaldownstream regulatory target in the Hippo signaling pathway that plays a pivotal role in organ size control and tumor suppression by restricting proliferation and promoting apoptosis. The core of this pathway is composed of a kinase cascade wherein STK3/MST2 and STK4/MST1, in complex with its regulatory protein SAV1, phosphorylates and activates LATS1/2 in complex with its regulatory protein MOB1, which in turn phosphorylates and inactivates YAP1 oncoprotein and WWTR1/TAZ. Plays a key role to control cell proliferation in response to cell contact. Phosphorylation of YAP1 by LATS1/2 inhibits its translocation into the nucleus to regulate cellular genes important for cell proliferation, cell death, and cell migration. The presence of TEAD transcription factors are required for it to stimulate gene expression, cell growth, anchorage-independent growth, and epithelial mesenchymal transition (EMT) induction. Isoform 2 and isoform 3 can activate the C-terminal fragment (CTF) of ERBB4 (isoform 3) Gene Wiki entry for YAP1
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Genomic Viewsfor YAP1 gene
(According to
GeneLoc and/or
HGNC , and/or
Entrez Gene (NCBI build 37) ,miRBase ,UCSC (hg19) and
Ensembl (release 69) ,
Regulatory elements and Epigenetics data according to
QIAGEN ,
SABiosciences , and/or
SwitchGear Genomics )About This Section RefSeq DNA sequence: NC_000011.9 NC_018922.1 NT_033899.8 Regulatory elements: SABiosciences Regulatory transcription factor binding sites in the YAP1 gene promoter:TBP p53 AP-1 p300 ATF-2 JunD TFIID c-Jun Other transcription factors Search SABiosciences Chromatin IP Primers for YAP1 Epigenetics: QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat YAP1
Genomic Location: Genomic View : UCSC Golden Path with GeneCards custom track Entrez Gene cytogenetic band: 11q13 Ensembl cytogenetic band: 11q22.1 HGNC cytogenetic band: 11q13 YAP1 Gene in genomic location: bands according to Ensembl, locations according to
Entrez Gene Ensembl GeneLoc information about chromosome 11 GeneLoc Exon Structure
GeneLoc location for GC11P102015: view genomic region
(about GC identifiers )
Start: 101,981,192 bp from pter End:
102,104,154 bp from pter
Size: 122,963 bases Orientation:
plus strand
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Proteinsfor YAP1 gene
(According to
1 UniProtKB ,
HORDE ,
neXtProt ,
Ensembl ,
and/or Reactome ,
Modification sites according to 2 PhosphoSitePlus ,
Specific Peptides from DME ,
Protein expression images according to data from SPIRE MOPED and PaxDb ,
RefSeq according to NCBI ,
PDB rendering according to OCA and/or Proteopedia ,
Recombinant Proteins
from
EMD Millipore ,
R&D Systems ,
GenScript ,
Enzo Life Sciences ,
OriGene ,
Novus Biologicals ,
Sino Biological ,
ProSpec , and/or
Uscn ,
EMD Millipore ,
R&D Systems ,
OriGene ,
GenScript ,
Cell Signaling Technology ,
Enzo Life Sciences , and/or
Uscn ,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene ,
Antibodies by
EMD Millipore ,
R&D Systems ,
GenScript ,
Cell Signaling Technology ,
OriGene ,
Novus Biologicals ,
Thermo Fisher Scientific ,
Abcam , and/or
Uscn )
About This Section UniProtKB/Swiss-Prot: YAP1_HUMAN, P46937 See
protein sequence )Recommended Name: Size : 504 amino acids; 54462 DaSubunit : Binds to the SH3 domain of the YES kinase. Binds to WBP1 and WBP2. Binds, in vitro, through the WW1 domain, toneural isoforms of ENAH that contain the PPSY motif (By similarity). The phosphorylated form interacts with YWHAB. Interacts (via WW domains) with LATS1 (via PPxY motif 2). Interacts with LATS2. Isoform 2 and isoform 3 interact (via WW domain 1) with isoform 3 of ERBB4 (via PPxY motif 2). Interacts with TEAD1, TEAD2, TEAD3 and TEAD4. Interacts with TP73. Interacts with RUNX1. Interacts with HCK. Interacts (via WW domains) with PTPN14 (via PPxY motif 2); this interaction leads to the cytoplasmic sequestration of YAP1 and inhibits its transcriptional coactivator activity
Subcellular location : Cytoplasm. Nucleus. Note=Both phosphorylation and cell density can regulate its subcellularlocalization. Phosphorylation sequesters it in the cytoplasm by inhibiting its translocation into the nucleus. At low density, predominantly nuclear and is translocated to the cytoplasm at high density. PTPN14 induces translocation from the nucleus to the cytoplasm
6/11 PDB 3D structures from (see all 11 ):1JMQ (3D) 1K5R (3D) 1K9Q (3D) 1K9R (3D) 2LAW (3D) 2LAX (3D) Secondary accessions : B4DTY1 Q7Z574 Q8IUY9Alternative splicing : 4 isoforms : P46937-1 P46937-2 P46937-3 P46937-4 (No experimental confirmation available)Explore the universe of human proteins at neXtProt for YAP1: NX_P46937 Post-translational modifications:
Phosphorylated by LATS1 and LATS2; leading to cytoplasmic translocation and inactivation. Phosphorylated by ABL1; leading to YAP1 stabilization, enhanced interaction with TP73 and recruitment onto proapoptotic genes; in response to DNA damage. Phosphorylation at Ser-400 and Ser-403 by CK1 is triggered by previous phosphorylation at Ser-397 by LATS proteins and leads to YAP1 ubiquitination by SCF(beta-TRCP) E3 ubiquitin ligase and subsequent degradation. Phosphorylated at Thr-119, Ser-138, Thr-154, Ser-367 and Thr-412 by MAPK8/JNK1 and MAPK9/JNK2, which is required for the regukation of apoptosis by YAP11
Ubiquitinated by SCF(beta-TRCP) E3 ubiquitin ligase1 View modification sites using PhosphoSitePlus 2 View neXtProt modification sites for NX_P46937 YAP1 Protein expression data from MOPED and PaxDb : About this image REFSEQ proteins (4 alternative transcripts): NP_001123617.1 NP_001181973.1 NP_001181974.1 NP_006097.2 ENSEMBL proteins: ENSP00000434134 ENSP00000282441 ENSP00000431574 ENSP00000435602 ENSP00000431626 ENSP00000445635 ENSP00000331023 Reactome Protein details: P46937 Human Recombinant Protein Products for YAP1: Gene Ontology (GO): 5 cellular component terms (GO ID links to tree view) : About this table
About GeneDecksing YAP1 Antibody Products: Assay Products for YAP1:
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Protein
Domains /for YAP1 gene (According to InterPro , ProtoNet ,
UniProtKB , and/or BLOCKS ,
Sets of similar genes according to GeneDecks )
About This Section About GeneDecksing 1 InterPro domain/family :
Graphical View of Domain Structure for InterPro Entry P46937 ProtoNet protein and cluster: P46937
1 Blocks protein family : IPB002349 UniProtKB/Swiss-Prot: YAP1_HUMAN, P46937 Similarity : Belongs to the YORKIE familySimilarity : Contains 2 WW domains
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Functionfor YAP1 gene
(According to 1 UniProtKB ,
Genatlas ,
LifeMap Discovery™ ,
IUBMB , and/or
2 DME ,
Human phenotypes from GenomeRNAi ,
Animal models from MGI Mar 06 2013,
inGenious Targeting Laboratory ,
SABiosciences ,
miRNA Gene Targets from miRTarBase ,
shRNA from
OriGene ,
Sirion Biotech ,
RNAi from
EMD Millipore ,
siRNAs from
OriGene ,
QIAGEN ,
microRNA from QIAGEN ,
Gene Editing from DNA2.0 ,
Sirion Biotech ,
Clones from EMD Millipore ,
OriGene ,
SwitchGear Genomics ,
GenScript ,
Sino Biological ,
DNA2.0 ,
and Vector BioLabs ,
Cell Lines from GenScript ,
LifeMap BioReagents ,
Sirion Biotech ,
In Situ Hybridization Assays from Advanced Cell Diagnostics ,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene .)
About This Section Molecular Function: UniProtKB/Swiss-Prot Summary: YAP1_HUMAN, P46937 Function : Transcriptional regulator which can act both as a coactivator and a corepressor and is the criticaldownstream regulatory target in the Hippo signaling pathway that plays a pivotal role in organ size control and tumor suppression by restricting proliferation and promoting apoptosis. The core of this pathway is composed of a kinase cascade wherein STK3/MST2 and STK4/MST1, in complex with its regulatory protein SAV1, phosphorylates and activates LATS1/2 in complex with its regulatory protein MOB1, which in turn phosphorylates and inactivates YAP1 oncoprotein and WWTR1/TAZ. Plays a key role to control cell proliferation in response to cell contact. Phosphorylation of YAP1 by LATS1/2 inhibits its translocation into the nucleus to regulate cellular genes important for cell proliferation, cell death, and cell migration. The presence of TEAD transcription factors are required for it to stimulate gene expression, cell growth, anchorage-independent growth, and epithelial mesenchymal transition (EMT) induction. Isoform 2 and isoform 3 can activate the C-terminal fragment (CTF) of ERBB4 (isoform 3)
Gene Ontology (GO): 5/7 molecular function terms (GO ID links to tree view) (see all 7 ): About this table
About GeneDecksing Phenotypes: 4 GenomeRNAi human phenotypes for YAP1 :13 MGI mutant phenotypes (inferred from 6 alleles(MGI details for Yap1) :About GeneDecksing Animal Models: Yap1 tm1Smil Yap1 tm1.2Dupa Clone Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human mouse rat see all 7 )human mouse rat see all 2 )OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling GenScript: all cDNA clones in your preferred vector (see all 2 ): YAP1 (NM_001117 ) Browse Sino Biological Human cDNA Clones DNA2.0 Custom Codon Optimized Gene
Synthesis Service for YAP1 Vector BioLabs ready-to-use adenovirus/AAV for human , mouse , rat YAP1
In Situ AssayAdvanced Cell Diagnostics RNAscope RNA in situ hybridization assays for YAP1
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Pathways & Interactionsfor YAP1 gene
(Pathways according to
EMD Millipore ,
R&D Systems ,
Cell Signaling Technology ,
KEGG ,
PharmGKB ,
BioSystems ,
Reactome ,
Tocris Bioscience ,
GeneGo (Thomson Reuters) ,
QIAGEN ,
and/or UniProtKB ,
Sets of similar genes according to GeneDecks ,
Interaction Networks according to
SABiosciences ,
and/or STRING ,
Interactions according to 1 UniProtKB ,
2 MINT ,
3 I2D , and/or
4 STRING ,
with links to IntAct and
Ensembl ,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene) .
About This Section Unified GeneCards pathways - 5/15 super-pathways (see all 15 ) About this table See pathways by source Super-pathway contained gene-specific pathways 1 Generic Transcription Pathway 2 Tyrosine Kinases / Adaptors 3 PI3K / Akt Signaling 4 CFTR-dependent regulation of ion channels in Airway Epithelium (norm and CF) 5 YAP1- and WWTR1 (TAZ)-stimulated gene expression
Pathway sources See GeneCards unified pathways Show all pathways 3 2 1 3 5/7 (see all 7 )About GeneDecksing Interactions: SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for YAP1 STRING Interaction
Network Preview (showing 5 interactants - click image to see 25)5/86 Interacting proteins for YAP1 (P46937 1 , 2 , 3 ENSP00000282441 4 via UniProtKB, MINT, STRING , and/or I2D (see all 86 )Interactant Interaction Details GeneCard External ID(s) TP73 O15350 2 , 3 ENSP00000367545 4 MINT-3388748 MINT-3388922 MINT-3388949 MINT-3388697 MINT-3388978 MINT-3388723 MINT-3388775 I2D:
score=4 STRING: ENSP00000367545 YWHAB P31946 2 , 3 ENSP00000300161 4 MINT-8008033 MINT-8009689 I2D:
score=1 STRING: ENSP00000300161 BTRC Q9Y297 2 , 3 ENSP00000359206 4 MINT-8249751 I2D:
score=2 STRING: ENSP00000359206 TP63 Q9H3D4 2 , 3 ENSP00000264731 4 MINT-3388996 I2D:
score=2 STRING: ENSP00000264731 MED28 Q9H204 2 , 3 ENSP00000237380 4 MINT-7041969 I2D:
score=1 STRING: ENSP00000237380
About this table Gene Ontology (GO): 5/26 biological process terms (GO ID links to tree view) (see all 26 ): About this table
GO ID Qualified GO term Evidence PubMed IDs GO:0001570 vasculogenesis
IEA -- GO:0003143 embryonic heart tube morphogenesis
IEA -- GO:0006355 regulation of transcription, DNA-dependent
-- -- GO:0006357 regulation of transcription from RNA polymerase II promoter
-- -- GO:0006366 transcription from RNA polymerase II promoter
-- --
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Drugs & Compoundsfor YAP1 gene (Chemical Compounds according to UniProtKB , Enzo Life Sciences ,
EMD Millipore , Tocris Bioscience
HMDB ,
BitterDB , and/or
Novoseek , and Drugs according to
DrugBank ,
Enzo Life Sciences , and/or
PharmGKB , with drugs/clinical trials/news
search links to CenterWatch )
About This Section About GeneDecksing Browse Tocris compounds for YAP1 3 Novoseek chemical compound relationships for YAP1 gene About this table YAP1
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Transcriptsfor YAP1 gene (Secondary structures according to
fRNAdb ,Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank , Entrez Gene ,
DOTS (version 10), and/or
AceView ,
transcript ids from Ensembl
with links to UCSC , GeneLoc ,
alternative splicing isoforms according to ASD and/or
ECgene ,EMD Millipore ,
OriGene ,
QIAGEN ,
shRNA from
OriGene ,
Sirion Biotech ,
microRNA from QIAGEN ,
OriGene ,
SwitchGear Genomics ,
GenScript ,
DNA2.0 ,
Vector BioLabs ,
Primers from
OriGene ,
SABiosciences , and/or
QIAGEN
)About This Section REFSEQ mRNAs for YAP1 gene (4 alternative transcripts): NM_001130145.2 NM_001195044.1 NM_001195045.1 NM_006106.4 Unigene Cluster for YAP1:
Yes-associated protein 1 Hs.503692 [show with all ESTs ] Unigene Representative Sequence: NM_001130145 9 Ensembl transcripts including schematic representations, and UCSC links where relevant : ENST00000526343 ENST00000282441 (uc001pgt.3 uc001pgu.3 uc001pgv.3 uc021qpf.1 uc010ruo.2 uc001pgw.2 uc010rup.1 )ENST00000531439 ENST00000524575 ENST00000526594 ENST00000529029 ENST00000528834 ENST00000537274 ENST00000345877 Clone OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human mouse rat see all 7 )human mouse rat see all 2 )OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling GenScript: all cDNA clones in your preferred vector (see all 2 ): YAP1 (NM_001117 ) DNA2.0 Custom Codon Optimized Gene
Synthesis Service for YAP1 Vector BioLabs ready-to-use adenovirus/AAV for human , mouse , rat YAP1
Additional cDNA sequence: AB567720.1 AB567721.1 AK300414.1 AK304485.1 AK310620.1 AK316116.1 AL832620.2 AY316529.1 BC026212.2 BC038235.1 HE864159.1 HE864160.1 HE864161.1 HE864162.1 HE864163.1
16 DOTS entries : DT.100824242 DT.446373
DT.91673001 DT.100043384 DT.91745842 DT.101979534 DT.120701800 DT.100824244 DT.307255 DT.120701732 DT.120701734 DT.120701753 DT.212517 DT.92436111 DT.95243946 DT.100710900 24/292 AceView cDNA sequences (see all 292 ):
BI261054 CA426862 AI831200 AI598122 AI128142 CK904064 BI223791 BU073244 BX089620 BC026212 BI966208 BQ008172 AA917078 AI590105 AW081855 AA887603 BM825245 BQ880612 AA182461 NM_006106 AI963820 BU622656 AI005171 AA610311 GeneLoc Exon Structure 5/7 Alternative Splicing Database (ASD) splice patterns (SP) for YAP1 (see all 7 ) About this scheme ExUns: 1a · 1b ^ 2 ^ 3a · 3b ^ 4 ^ 5 ^ 6a · 6b ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12a · 12b · 12c · 12d · 12e · 12f SP1 : - - - SP2 : - - - - SP3 : - - SP4 : - - - - SP5 :
ECgene alternative splicing isoforms for YAP1
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Expression for YAP1 gene
(RNA expression data according to
H-InvDB ,
NONCODE ,
miRBase , and
RNAdb ,
Expression images according to data from
BioGPS ,
Illumina Human BodyMap , and
CGAP
SAGE ,
Sets of similar genes according to GeneDecks ,
in vivo and in vitro expression data from LifeMap Discovery™ ,
plus additional links to
Genevestigator , and/or
SOURCE , and/or
BioGPS , and/or
UniProtKB ,SABiosciences ,
Primers from
OriGene ,
SABiosciences , and/or
QIAGEN ,
In Situ Hybridization Assays from Advanced Cell Diagnostics )
About This Section YAP1 expression in normal human tissues (normalized intensities) See probesets specificity/sensitivity at GeneAnnot About this image BioGPS CGAP TAG: CTCATATGTTAbout this image YAP1 expression in embryonic tissues and stem cells About this table
See YAP1 Protein Expression from SPIRE MOPED and PaxDB Genevestigator expression for YAP1 SOURCE GeneReport for Unigene cluster: Hs.503692 UniProtKB/Swiss-Prot: YAP1_HUMAN, P46937 Tissue specificity : Increased expression seen in some liver and prostate cancers. Isoforms lacking the transactivationdomain found in striatal neurons of patients with Huntington disease (at protein level) SABiosciences Expression via Pathway-Focused PCR Array including YAP1 : Primer OriGene genome-wide validated SYBR primer pairs in human mouse rat Browse OriGene validated miRNA SYBR primer pairs SABiosciences RT2 qPCR Primer Assay in human mouse rat QIAGEN QuantiTect SYBR Green Assays in human mouse rat QIAGEN QuantiFast Probe-based Assays in human mouse rat In Situ Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for YAP1
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Orthologsfor YAP1 gene
(Orthologs according to
1,2 HomoloGene (2 older version, for species not in 1 newer version),
3 euGenes ,
4 SGD
,
5 MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase ,
and/or
6 Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam )
About This Section Orthologs for YAP1 gene from 5/18 species (see all 18 ) About this table
Organism
Taxonomic
Gene
Description
Human
Orthology
Details
chicken Aves YAP11
Yes-associated protein 1
82.22(n) 89.06(a)
396171 NM_205243.1 NP_990574.1
lizard Reptilia YAP16
--
92(a)
1 ↔ 1
3(192366679-192416810)
African clawed frog Amphibia Xl.76562
Xenopus laevis transcribed sequence with moderate similarity more
79.48(n)
BJ619727.1
zebrafish Actinopterygii Dr.126982
Transcribed sequence with moderate similarity to protein more
76.72(n)
CD750884.1
fruit fly Insecta yki6
yorkie
26(a)
1 → many
2R(19953498-19956008)
ENSEMBL Gene Tree for YAP1 (if available)TreeFam Gene Tree for YAP1 (if available)
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Paralogsfor YAP1 gene (Paralogs according to
1 HomoloGene ,2 Ensembl , and 3 SIMAP , Pseudogenes according to 4 Pseudogene.org Build 68)About This Section Paralogs for YAP1 gene WWTR1 2 4 SIMAP similar genes for YAP1 using alignment to 9 protein entries: YAP1_HUMAN (see all proteins ):YAP DKFZp451O0517 WWC2 WWTR1 About GeneDecksing 3 Pseudogenes.org Pseudogenes for YAP1 PGOHUM00000243353 PGOHUM00000243810 PGOHUM00000241958
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Genomic Variantsfor YAP1 gene (SNPs/Variants according to the
1 NCBI SNP Database ,
2 Ensembl ,
3 PupaSUITE ,
UniProtKB , and
DNA2.0 ,
Linkage Disequilibrium by HapMap ,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants , Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB) , Blood group antigen gene mutations by BGMUT ,
Resequencing Primers from QIAGEN ,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences )
About This Section Genomic Data Transcription Related Data Allele Frequencies SNP ID Valid Clinical Chr 11 pos Sequence # AA Type More # Allele Pop Total More
HapMap Linkage Disequilibrium report for YAP1 (101981192 - 102104154 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions) Database of Genomic Variants (DGV): 1 variation for YAP1 1 CNV 101319 Human Gene Mutation Database (HGMD) : YAP1 SABiosciences Cancer Mutation PCR Assays
QIAGEN SeqTarget long-range PCR primers in human mouse rat
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Disorders
/ Diseasesfor YAP1 gene
(in which this Gene is Involved, According to MalaCards ,
OMIM, UniProtKB ,
the University of Copenhagen DISEASES
database , Novoseek ,
Genatlas , GeneTests ,
GAD ,
HuGE Navigator ,
and/or TGDB .)
About This Section About GeneDecksing OMIM gene information: 606608
OMIM disorders : --20/24 (see all 24 ): About MalaCards japanese spotted fever spotted fever oral squamous cell carcinoma squamous cell carcinoma pancreatic ductal adenocarcinoma huntington's disease neurofibromatosis liver cancer medulloblastoma hepatocellular carcinoma alzheimer's disease ovarian cancer gastric cancer meningioma lung cancer adenocarcinoma carcinoma prostate cancer pancreatitis glioblastoma 1 disease from the University of Copenhagen DISEASES database for YAP1 :Japanese spotted fever 2 Novoseek disease relationships for YAP1 gene About this table
Human Genome Epidemiology (HuGE) Navigator: YAP1 (2 documents) Export disorders for YAP1 gene to outside databases
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Publicationsfor YAP1 gene (in
PubMed .
Associations of this gene to articles via
1 Entrez Gene ,
2 UniProtKB/Swiss-Prot ,
3 HGNC ,
4 GAD ,
5 PharmGKB ,
6 HMDB ,
7 DrugBank ,
8 UniProtKB/TrEMBL ,
9 Novoseek , and/or
10 fRNAdb )
About This Section PubMed articles for YAP1 gene, integrated from 9 sources (see all 179 ):(articles sorted by number of sources associating them with YAP1) Utopia : connect your pdf to the dynamic
Characterization of the mammalian YAP (Yes-associated protein) gene and its role in defining a novel protein module, the WW domain. (PubMed id 7782338) 1 , 2 , 3, 9(1995) A coordinated phosphorylation by Lats and CK1 regulat es YAP stability through SCF(beta-TRCP). (PubMed id 20048001) 1 , 2 , 9(2010) WW domain-containing protein YAP associates with ErbB-4 and acts as a co-transcriptional activator for the carboxyl-terminal fragment of ErbB-4 that translocates to the nucleus. (PubMed id 12807903) 1 , 2 , 9(2003) Inactivation of YAP oncoprotein by the Hippo pathway is involved in cell contact inhibition and tissue growth control. (PubMed id 17974916) 1 , 2 , 9(2007) JNK phosphorylates Yes-associated protein (YAP) to regulate apoptosis. (PubMed id 21364637) 1 , 2 (2010) Tumor suppressor LATS1 is a negative regulator of oncogene YAP. (PubMed id 18158288) 1 , 2 (2008) Yap1 phosphorylation by c-Abl is a critical step in selective activation of proapoptotic genes in response to DNA damage. (PubMed id 18280240) 1 , 2 (2008) Global, in vivo, and site-specific phosphorylation dynamics in signaling networks. (PubMed id 17081983) 1 , 2 (2006) Solution structures of the YAP65 WW domain and the variant L30 K in complex with the peptides GTPPPPYTVG, N-(n-octyl)-GPPPY and PLPPY and the application of peptide libraries reveal a minimal binding epitope. (PubMed id 11743730) 1 , 2 (2001) Characterization of the WW domain of human Yes-associated protein and its polyproline containing ligands. (PubMed id 9202023) 1 , 2 (1997)
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About This Section Patent Information for YAP1 gene: YAP1 GeneCards and IP: Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
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Productsfor YAP1 gene (Antibodies, recombinant proteins, and assays from EMD Millipore , R&D Systems , OriGene , QIAGEN , GenScript , Cell Signaling Technology , SABiosciences , Novus Biologicals , Sino Biological , Enzo Life Sciences , Abcam , ProSpec , Uscn , Thermo Fisher Scientific , Gene Editing from DNA2.0 and Sirion Biotech , Clones from EMD Millipore , OriGene , GenScript , Sino Biological , DNA2.0 , SwitchGear Genomics , Vector BioLabs , Cell lines from GenScript , LifeMap BioReagents , and Sirion Biotech , PCR Arrays from SABiosciences , Drugs and/or compounds from EMD Millipore , Tocris Bioscience , and/or
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