External Ids for YAF2 Gene
Previous GeneCards Identifiers for YAF2 Gene
The protein encoded by this gene interacts with YY1, a zinc finger protein involved in negative regulation of muscle-restricted genes. This gene product itself contains a single N-terminal C2-X10-C2 zinc finger, and in contrast to YY1, is up-regulated during myogenic differentiation. It also facilitates proteolytic cleavage of YY1 by the calcium- activated protease, m-calpain, suggesting a mechanism by which this protein antagonizes the negative effect of YY1. Multiple alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Jul 2010]
GeneCards Summary for YAF2 Gene
YAF2 (YY1 Associated Factor 2) is a Protein Coding gene. Diseases associated with YAF2 include facioscapulohumeral muscular dystrophy 1. GO annotations related to this gene include transcription coactivator activity and transcription corepressor activity. An important paralog of this gene is RYBP.
UniProtKB/Swiss-Prot for YAF2 Gene
Binds to MYC and inhibits MYC-mediated transactivation. Also binds to MYCN and enhances MYCN-dependent transcriptional activation. Increases calpain 2-mediated proteolysis of YY1 in vitro. Component of the E2F6.com-1 complex, a repressive complex that methylates Lys-9 of histone H3, suggesting that it is involved in chromatin-remodeling.