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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

YAF2 Gene

protein-coding   GIFtS: 56
GCID: GC12M042550

YY1 Associated Factor 2

  Search for YAF2
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

This gene clusters with an RNA gene
Subcategory (RNA class): lncRNA

Quality score for the ORGUL clustered with this gene is 3

Aliases
YY1 Associated Factor 21 2
YY1-Associated Factor 22

External Ids:    HGNC: 173631   Entrez Gene: 101382   Ensembl: ENSG000000151537   OMIM: 6075345   UniProtKB: Q8IY573   
ORGUL members:         
NONCODE14:n409617      

Export aliases for YAF2 gene to outside databases

Previous GC identifers: GC12M042627 GC12M042453 GC12M042269 GC12M040839 GC12M039578


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for YAF2 Gene:
The protein encoded by this gene interacts with YY1, a zinc finger protein involved in negative regulation of
muscle-restricted genes. This gene product itself contains a single N-terminal C2-X10-C2 zinc finger, and in
contrast to YY1, is up-regulated during myogenic differentiation. It also facilitates proteolytic cleavage of YY1
by the calcium- activated protease, m-calpain, suggesting a mechanism by which this protein antagonizes the
negative effect of YY1. Multiple alternatively spliced transcript variants have been found for this gene.
(provided by RefSeq, Jul 2010)

GeneCards Summary for YAF2 Gene: 
YAF2 (YY1 associated factor 2) is a protein-coding gene, and is affiliated with the lncRNA class. GO annotations related to this gene include transcription coactivator activity and transcription corepressor activity. An important paralog of this gene is RYBP.

UniProtKB/Swiss-Prot: YAF2_HUMAN, Q8IY57
Function: Binds to MYC and inhibits MYC-mediated transactivation. Also binds to MYCN and enhances MYCN-dependent
transcriptional activation. Increases calpain 2-mediated proteolysis of YY1 in vitro. Component of the E2F6.com-1
complex, a repressive complex that methylates 'Lys-9' of histone H3, suggesting that it is involved in
chromatin-remodeling

Gene Wiki entry for YAF2 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000012.11  NT_029419.12  NC_018923.2  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the YAF2 gene promoter:
         c-Fos   USF1   AP-1   JunB   Fra-1   FosB   PPAR-gamma1   JunD   c-Jun   PPAR-gamma2   
         Other transcription factors

Browse SwitchGear Promoter luciferase reporter plasmids
   Search SABiosciences Chromatin IP Primers for YAF2

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat YAF2


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 12q12   Ensembl cytogenetic band:  12q12   HGNC cytogenetic band: 12q12

YAF2 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
YAF2 gene location

GeneLoc information about chromosome 12         GeneLoc Exon Structure

GeneLoc location for GC12M042550:  view genomic region     (about GC identifiers)

Start:
42,550,906 bp from pter      End:
42,632,154 bp from pter
Size:
81,249 bases      Orientation:
minus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: YAF2_HUMAN, Q8IY57 (See protein sequence)
Recommended Name: YY1-associated factor 2  
Size: 180 amino acids; 19901 Da
Subunit: Interacts with MYC, MYCN, RNF2/RING1B and YY1. Part of the E2F6.com-1 complex in G0 phase composed of
E2F6, MGA, MAX, TFDP1, CBX3, BAT8, EUHMTASE1, RING1, RNF2, MBLR, L3MBTL2 and YAF2
Subcellular location: Nucleus
1 PDB 3D structure from and Proteopedia for YAF2:
2D9G (3D)    
Secondary accessions: A8K5P0 B4DFU3 G3V465 Q99710
Alternative splicing: 4 isoforms:  Q8IY57-1   Q8IY57-2   Q8IY57-3   Q8IY57-4   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for YAF2: NX_Q8IY57

Explore proteomics data for YAF2 at MOPED 

Post-translational modifications:

  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_Q8IY57

  • YAF2 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    YAF2 Protein Expression
    REFSEQ proteins (4 alternative transcripts): 
    NP_001177906.1  NP_001177908.1  NP_001177909.1  NP_005739.2  

    ENSEMBL proteins: 
     ENSP00000401859   ENSP00000439256   ENSP00000370167   ENSP00000448533   ENSP00000450394  
     ENSP00000448291   ENSP00000447217   ENSP00000447863   ENSP00000450097   ENSP00000447686  
     ENSP00000448312   ENSP00000328004   ENSP00000370165   ENSP00000451626  

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    Browse Sino Biological Cell Lysates 
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    Cloud-Clone Corp. Proteins for YAF2 

    Gene Ontology (GO): 4 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005622intracellular ----
    GO:0005634nucleus IDA--
    GO:0005730NOT nucleolus IDA--
    GO:0005737cytoplasm IDA--

    YAF2 for ontologies           About GeneDecksing



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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    1 InterPro protein domain:
     IPR001876 Znf_RanBP2

    Graphical View of Domain Structure for InterPro Entry Q8IY57

    ProtoNet protein and cluster: Q8IY57

    1 Blocks protein domain: IPB001876 Zn-finger

    UniProtKB/Swiss-Prot: YAF2_HUMAN, Q8IY57
    Similarity: Contains 1 RanBP2-type zinc finger


    YAF2 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: YAF2_HUMAN, Q8IY57
    Function: Binds to MYC and inhibits MYC-mediated transactivation. Also binds to MYCN and enhances MYCN-dependent
    transcriptional activation. Increases calpain 2-mediated proteolysis of YY1 in vitro. Component of the E2F6.com-1
    complex, a repressive complex that methylates 'Lys-9' of histone H3, suggesting that it is involved in
    chromatin-remodeling

         Gene Ontology (GO): 4 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003713transcription coactivator activity IDA11593398
    GO:0003714transcription corepressor activity IDA12706874
    GO:0005515protein binding IPI11593398
    GO:0008270zinc ion binding IEA--
         
    YAF2 for ontologies           About GeneDecksing


    Phenotypes:
         1 GenomeRNAi human phenotype for YAF2:
     Decreased Salmonella enterica  

    Animal Models:
       inGenious Targeting Laboratory - Custom generated mouse model solutions for YAF2 
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    SwitchGear 3'UTR luciferase reporter plasmidYAF2 3' UTR sequence
    Inhib. RNA
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    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section



    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for YAF2

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    5/63 Interacting proteins for YAF2 (Q8IY572, 3 ENSP000003280044) via UniProtKB, MINT, STRING, and/or I2D (see all 63)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    ENSG00000235107Q065872, 3, ENSP000003964394MINT-8010325 MINT-8010390 I2D: score=1 STRING: ENSP00000396439
    ENSG00000206287Q065872, 3MINT-8010325 MINT-8010390 I2D: score=1 
    ENSG00000226788Q065872, 3MINT-8010325 MINT-8010390 I2D: score=1 
    ENSG00000228520Q065872, 3MINT-8010325 MINT-8010390 I2D: score=1 
    ENSG00000231115Q065872, 3MINT-8010325 MINT-8010390 I2D: score=1 
    About this table

    Gene Ontology (GO): 3 biological process terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006351transcription, DNA-dependent IEA--
    GO:0045892negative regulation of transcription, DNA-dependent IDA12706874
    GO:0045893positive regulation of transcription, DNA-dependent IDA11593398

    YAF2 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for YAF2

    Search CenterWatch for drugs/clinical trials and news about YAF2

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for YAF2 gene (5 alternative transcripts): 
    NM_001190977.1  NM_001190979.1  NM_001190980.1  NM_005748.4  NM_001012424.1  

    Unigene Cluster for YAF2:

    YY1 associated factor 2
    Hs.708084  [show with all ESTs]
    Unigene Representative Sequence: NM_001190980
    18/21 Ensembl transcripts including schematic representations, and UCSC links where relevant (see all 21):
    ENST00000442791 ENST00000534854 ENST00000380790 ENST00000550315 ENST00000552109
    ENST00000547622 ENST00000547351 ENST00000551268 ENST00000551528 ENST00000548661
    ENST00000546972 ENST00000546726 ENST00000547724 ENST00000552928 ENST00000548917
    ENST00000547254 ENST00000541702 ENST00000546782
    miRNA
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    8/166 QIAGEN miScript miRNA Assays for microRNAs that regulate YAF2 (see all 166):
    hsa-miR-124* hsa-miR-579 hsa-miR-3653 hsa-miR-3921 hsa-miR-3916 hsa-miR-877* hsa-miR-376a* hsa-miR-761
    SwitchGear 3'UTR luciferase reporter plasmidYAF2 3' UTR sequence
    Inhib. RNA
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    Additional mRNA sequence: 

    AK127531.1 AK291355.1 AK294260.1 AK296191.1 BC037777.2 NR_034000.1 

    15 DOTS entries:

    DT.100713349  DT.95370291  DT.311602  DT.100785008  DT.95165738  DT.95193729  DT.91955631  DT.121192305 
    DT.121192450  DT.87017814  DT.100718765  DT.121192299  DT.95165737  DT.97837659  DT.91658529 

    24/116 AceView cDNA sequences (see all 116):

    BM995328 F02419 BF477716 AI078329 AA384399 BU170747 BQ010643 F10745 
    Z39046 AW073893 AA385199 Z42926 AI285403 F02402 AI743991 BM068838 
    AA765439 BU541658 F06135 BP375794 F06147 BU619569 AU279420 CK904670 

    GeneLoc Exon Structure

    5/7 Alternative Splicing Database (ASD) splice patterns (SP) for YAF2 (see all 7)    About this scheme

    ExUns: 1a · 1b ^ 2a · 2b ^ 3 ^ 4 ^ 5a · 5b · 5c ^ 6 ^ 7 ^ 8
    SP1:              -           -     -     -                 -     -         
    SP2:                                                                        
    SP3:              -           -     -     -     -     -     -     -         
    SP4:              -           -                                             
    SP5:                                                              -         


    ECgene alternative splicing isoforms for YAF2

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    YAF2 expression in normal human tissues (normalized intensities)      YAF2 embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: TGGTAATGTA
    YAF2 Expression
    About this image


    YAF2 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database 
     5/35 selected tissues (see all 35) fully expand
     
     Epithelium
             vagina ; squamous epithelial cells   
     
     Testis (Reproductive System)    fully expand to see all 4 entries
             Leydig Cells Testis Interstitium
             seminal vesicle ; glandular cells   
     
     Colon (Gastrointestinal Tract)    fully expand to see all 4 entries
             colon ; peripheral nerve/ganglion   
     
     Brain (Nervous System)    fully expand to see all 4 entries
             Cerebral Cortex
     
     Uterus (Reproductive System)    fully expand to see all 4 entries
             uterus, post-menopause ; glandular cells   

    See YAF2 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for YAF2

    SOURCE GeneReport for Unigene cluster: Hs.708084
        SABiosciences Expression via Pathway-Focused PCR Array including YAF2: 
              Polycomb & Trithorax Complexes in human mouse rat

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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for YAF2

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of animals.

    Orthologs for YAF2 gene from 6/14 species (see all 14)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Yaf21 , 5 YY1 associated factor 21, 5 85.85(n)1
    92.18(a)1
      15 (47.39 cM)5
    670571  NM_024189.61  NP_077151.31 
     932842785 
    chicken
    (Gallus gallus)
    Aves YAF21 YY1 associated factor 2 92.78(n)
    99.44(a)
      417790  NM_001007850.1  NP_001007851.1 
    lizard
    (Anolis carolinensis)
    Reptilia YAF26
    Uncharacterized protein
    98(a)
    1 ↔ 1
    5(55315245-55352809)
    African clawed frog
    (Xenopus laevis)
    Amphibia Xl.217742 Xenopus laevis transcribed sequence with moderate similarity more 85.69(n)    BJ093210.1 
    zebrafish
    (Danio rerio)
    Actinopterygii yaf21 YY1 associated factor 2 75.74(n)
    82.78(a)
      692296  NM_001045268.1  NP_001038733.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta RYBP6
    Ring and YY1 Binding Protein
    47(a)
    1 → many
    2R(18558257-18560717)


    ENSEMBL Gene Tree for YAF2 (if available)
    TreeFam Gene Tree for YAF2 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for YAF2 gene
    RYBP2  
    1 SIMAP similar gene for YAF2 using alignment to 9 protein entries:     YAF2_HUMAN (see all proteins):
    RYBP

    YAF2 for paralogs           About GeneDecksing


    1 Pseudogenes.org Pseudogene for YAF2
    PGOHUM00000262036


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/1602 SNPs in YAF2 are shown (see all 1602)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 12 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs124251061,2
    C,F,H--42550443(+) TGCCTG/ATGATA 4 -- ds50015Minor allele frequency- A:0.01NS EA NA 540
    rs583691301,2
    C,F--42550546(+) TGTAAC/TCTTGT 4 -- ds50011Minor allele frequency- T:0.04WA 118
    rs128219241,2
    H--42550569(+) ATCAGT/GGATTT 4 -- ds50014Minor allele frequency- G:0.00NS EA 418
    rs7121101,2
    F--42550598(-) AAGAAA/TTTCAG 4 -- ds50013Minor allele frequency- T:0.03NA WA 122
    rs128220901,2
    H--42550625(+) CTTTGT/GTCCAG 4 -- ds50014Minor allele frequency- G:0.00NS EA 418
    rs1840706341,2
    --42550686(+) CAAAGC/TGTTCT 4 -- ds50010--------
    rs1382623471,2
    --42550712(+) CTTACA/GTACGC 4 -- ds50010--------
    rs1496273801,2
    --42550759(+) AGTGCA/GGAAAC 4 -- ds50010--------
    rs111813541,2
    C,F,H--42550839(+) AGTAGC/GAGAGC 4 -- ds50016Minor allele frequency- G:0.06NS EA CSA NA 533
    rs340142271,2
    C--42550865(+) TCCAC-/TTTTTT 4 -- ds50013Minor allele frequency- T:0.17NA CSA 6

    HapMap Linkage Disequilibrium report for YAF2 (42550906 - 42632154 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 2 variations for YAF2:    About this table     
    Variant IDTypeSubtypePubMed ID
    nsv437751CNV Loss16327808
    dgv287n67CNV Gain20364138

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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section

    YAF2 for disorders           About MalaCards
    OMIM gene information: 607534    OMIM disorders: --


    YAF2 for disorders           About GeneDecksing

    Genetic Association Database (GAD): YAF2
    Human Genome Epidemiology (HuGE) Navigator: YAF2 (2 documents)

    Export disorders for YAF2 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for YAF2 gene, integrated from 9 sources (see all 23):
    (articles sorted by number of sources associating them with YAF2)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Yeast two-hybrid cloning of a novel zinc finger protein that interacts with the multifunctional transcription factor YY1. (PubMed id 9016636)1, 2, 3, 9 Kalenik J.L.... Lee T.-C. (1997)
    2. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PubMed id 20379614)1, 4 Rose J.E....Uhl G.R. (2010)
    3. Coeliac disease associated risk variants in TNFAIP3 and REL implicate altered NF-{kappa}B signalling. (PubMed id 19240061)1, 4 Trynka G....Wijmenga C. (2009)
    4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    5. Yaf2 inhibits Myc biological function. (PubMed id 12706874)1, 2 Maedge B.... Schwab M. (2003)
    6. A complex with chromatin modifiers that occupies E2F- and Myc- responsive genes in G0 cells. (PubMed id 12004135)1, 2 Ogawa H.... Nakatani Y. (2002)
    7. Functional interaction of Yaf2 with the central region of MycN. (PubMed id 11593398)1, 2 Bannasch D.... Schwab M. (2001)
    8. Interlaboratory reproducibility of large-scale human p rotein-complex analysis by standardized AP-MS. (PubMed id 23455922)1 Varjosalo M....Superti-Furga G. (2013)
    9. Systems-wide analysis of ubiquitylation dynamics reveals a key role for PAF15 ubiquitylation in DNA-damage bypass. (PubMed id 23000965)1 Povlsen L.K....Choudhary C. (2012)
    10. PCGF homologs, CBX proteins, and RYBP define functiona lly distinct PRC1 family complexes. (PubMed id 22325352)1 Gao Z....Reinberg D. (2012)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Free Text  

      Query String
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    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 10138 HGNC: 17363 AceView: YAF2 Ensembl:ENSG00000015153 euGenes: HUgn10138
    ECgene: YAF2 H-InvDB: YAF2

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for YAF2 Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for YAF2 Genetics and Cytogenetics in Oncology and Haematology

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for YAF2 gene:
    Search GeneIP for patents involving YAF2

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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    GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 4 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

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