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YAF2 Gene

protein-coding   GIFtS: 54
GCID: GC12M042550

YY1 Associated Factor 2

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(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
YY1 Associated Factor 21 2
YY1-Associated Factor 22

External Ids:    HGNC: 173631   Entrez Gene: 101382   Ensembl: ENSG000000151537   OMIM: 6075345   UniProtKB: Q8IY573   

Export aliases for YAF2 gene to outside databases

Previous GC identifers: GC12M042627 GC12M042453 GC12M042269 GC12M040839 GC12M039578


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for YAF2 Gene:
The protein encoded by this gene interacts with YY1, a zinc finger protein involved in negative regulation of
muscle-restricted genes. This gene product itself contains a single N-terminal C2-X10-C2 zinc finger, and in
contrast to YY1, is up-regulated during myogenic differentiation. It also facilitates proteolytic cleavage of YY1
by the calcium- activated protease, m-calpain, suggesting a mechanism by which this protein antagonizes the
negative effect of YY1. Multiple alternatively spliced transcript variants have been found for this gene.
(provided by RefSeq, Jul 2010)

GeneCards Summary for YAF2 Gene:
YAF2 (YY1 associated factor 2) is a protein-coding gene. GO annotations related to this gene include transcription coactivator activity and transcription corepressor activity. An important paralog of this gene is RYBP.

UniProtKB/Swiss-Prot: YAF2_HUMAN, Q8IY57
Function: Binds to MYC and inhibits MYC-mediated transactivation. Also binds to MYCN and enhances MYCN-dependent
transcriptional activation. Increases calpain 2-mediated proteolysis of YY1 in vitro. Component of the E2F6.com-1
complex, a repressive complex that methylates 'Lys-9' of histone H3, suggesting that it is involved in
chromatin-remodeling

Gene Wiki entry for YAF2 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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Regulatory elements:
   Regulatory transcription factor binding sites in the YAF2 gene promoter:
         c-Fos   USF1   AP-1   JunB   Fra-1   FosB   PPAR-gamma1   JunD   c-Jun   PPAR-gamma2   
         Other transcription factors

Browse SwitchGear Promoter luciferase reporter plasmids
   Search Chromatin IP Primers for YAF2

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat YAF2


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 12q12   Ensembl cytogenetic band:  12q12   HGNC cytogenetic band: 12q12

YAF2 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
YAF2 gene location

GeneLoc information about chromosome 12         GeneLoc Exon Structure

GeneLoc location for GC12M042550:  view genomic region     (about GC identifiers)

Start:
42,550,906 bp from pter      End:
42,632,154 bp from pter
Size:
81,249 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., eBioscience, and/or antibodies-online,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., eBioscience, and/or antibodies-online, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, Cloud-Clone Corp, antibodies-online, and/or others.)
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UniProtKB/Swiss-Prot: YAF2_HUMAN, Q8IY57 (See protein sequence)
Recommended Name: YY1-associated factor 2  
Size: 180 amino acids; 19901 Da
Subunit: Interacts with MYC, MYCN, RNF2/RING1B and YY1. Part of the E2F6.com-1 complex in G0 phase composed of
E2F6, MGA, MAX, TFDP1, CBX3, BAT8, EUHMTASE1, RING1, RNF2, MBLR, L3MBTL2 and YAF2
1 PDB 3D structure from and Proteopedia for YAF2:
2D9G (3D)    
Secondary accessions: A8K5P0 B4DFU3 G3V465 Q99710
Alternative splicing: 4 isoforms:  Q8IY57-1   Q8IY57-2   Q8IY57-3   Q8IY57-4   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for YAF2: NX_Q8IY57

Explore proteomics data for YAF2 at MOPED

Post-translational modifications: 

  • Ubiquitination2 at Lys38
  • Modification sites at PhosphoSitePlus

  • See YAF2 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (4 alternative transcripts): 
    NP_001177906.1  NP_001177908.1  NP_001177909.1  NP_005739.2  

    ENSEMBL proteins: 
     ENSP00000401859   ENSP00000439256   ENSP00000370167   ENSP00000448533   ENSP00000450394  
     ENSP00000448291   ENSP00000447217   ENSP00000447863   ENSP00000450097   ENSP00000447686  
     ENSP00000448312   ENSP00000328004   ENSP00000370165   ENSP00000451626  

    YAF2 Human Recombinant Protein Products:

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    Cloud-Clone Corp. Proteins for YAF2

     
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    antibodies-online proteins for YAF2 (6 products) 

     
    antibodies-online peptides for YAF2

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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    1 InterPro protein domain:
     IPR001876 Znf_RanBP2

    Graphical View of Domain Structure for InterPro Entry Q8IY57

    ProtoNet protein and cluster: Q8IY57

    1 Blocks protein domain: IPB001876 Zn-finger

    UniProtKB/Swiss-Prot: YAF2_HUMAN, Q8IY57
    Similarity: Contains 1 RanBP2-type zinc finger


    Find genes that share domains with YAF2           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: YAF2_HUMAN, Q8IY57
    Function: Binds to MYC and inhibits MYC-mediated transactivation. Also binds to MYCN and enhances MYCN-dependent
    transcriptional activation. Increases calpain 2-mediated proteolysis of YY1 in vitro. Component of the E2F6.com-1
    complex, a repressive complex that methylates 'Lys-9' of histone H3, suggesting that it is involved in
    chromatin-remodeling

         Gene Ontology (GO): 4 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003713transcription coactivator activity IDA11593398
    GO:0003714transcription corepressor activity IDA12706874
    GO:0005515protein binding IPI11593398
    GO:0008270zinc ion binding IEA--
         
    Find genes that share ontologies with YAF2           About GenesLikeMe


    Phenotypes:
         1 GenomeRNAi human phenotype for YAF2:
     Decreased Salmonella enterica  

    Animal Models:
       genOway: Develop your customized and physiologically relevant rodent model for YAF2

    miRNA
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    miRTarBase miRNAs that target YAF2:
    hsa-mir-103a-3p (MIRT027053)

    Block miRNA regulation of human, mouse, rat YAF2 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate YAF2 (see all 166):
    hsa-miR-124* hsa-miR-579 hsa-miR-3653 hsa-miR-3921 hsa-miR-3916 hsa-miR-877* hsa-miR-376a* hsa-miR-761
    SwitchGear 3'UTR luciferase reporter plasmidYAF2 3' UTR sequence
    Inhib. RNA
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    Browse Sino Biological Human cDNA Clones
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    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    YAF2_HUMAN, Q8IY57: Nucleus
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    nucleus5
    cytosol3

    Gene Ontology (GO): 3 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus IDA--
    GO:0005730NOT nucleolus IDA--
    GO:0005737cytoplasm IDA--

    Find genes that share ontologies with YAF2           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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        Pathway & Disease-focused RT2 Profiler PCR Array including YAF2: 
              Polycomb & Trithorax Complexes in human mouse rat

    Interactions:

        GeneGlobe Interaction Network for YAF2

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for YAF2 (Q8IY572, 3 ENSP000003280044) via UniProtKB, MINT, STRING, and/or I2D (see all 63)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    ENSG00000235107Q065872, 3, ENSP000003964394MINT-8010325 MINT-8010390 I2D: score=1 STRING: ENSP00000396439
    ENSG00000206287Q065872, 3MINT-8010325 MINT-8010390 I2D: score=1 
    ENSG00000226788Q065872, 3MINT-8010325 MINT-8010390 I2D: score=1 
    ENSG00000228520Q065872, 3MINT-8010325 MINT-8010390 I2D: score=1 
    ENSG00000231115Q065872, 3MINT-8010325 MINT-8010390 I2D: score=1 
    About this table

    Gene Ontology (GO): 3 biological process terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006351transcription, DNA-templated IEA--
    GO:0045892negative regulation of transcription, DNA-templated IDA12706874
    GO:0045893positive regulation of transcription, DNA-templated IDA11593398

    Find genes that share ontologies with YAF2           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for YAF2



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for YAF2 gene (5 alternative transcripts): 
    NM_001190977.1  NM_001190979.1  NM_001190980.1  NM_005748.4  NM_001012424.1  

    Selected Ensembl transcripts including schematic representations, and UCSC links where relevant (see all 21):
    ENST00000442791 ENST00000534854 ENST00000380790 ENST00000550315 ENST00000552109
    ENST00000547622 ENST00000547351 ENST00000551268 ENST00000551528 ENST00000548661
    ENST00000546972 ENST00000546726 ENST00000547724 ENST00000552928 ENST00000548917
    ENST00000547254 ENST00000541702 ENST00000546782
    miRNA
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    Selected qRT-PCR Assays for microRNAs that regulate YAF2 (see all 166):
    hsa-miR-124* hsa-miR-579 hsa-miR-3653 hsa-miR-3921 hsa-miR-3916 hsa-miR-877* hsa-miR-376a* hsa-miR-761
    SwitchGear 3'UTR luciferase reporter plasmidYAF2 3' UTR sequence
    Inhib. RNA
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    GenScript: all cDNA clones in your preferred vector (see all 4): YAF2 (NM_005748)
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    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat YAF2
    Primer
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    OriGene qSTAR qPCR primer pairs in human, mouse for YAF2
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat YAF2
      QuantiTect SYBR Green Assays in human, mouse, rat YAF2
      QuantiFast Probe-based Assays in human, mouse, rat YAF2

    Selected AceView cDNA sequences (see all 116):

    BX649019 AU279420 CK904670 AA568443 BU543113 BU619569 BP375794 F02402 
    AI285403 AA765439 BM023254 BU541658 F06147 F06135 AA385199 BM995328 
    BE894451 BU170747 AI743991 AW073893 F02419 BM068838 F10745 BQ010643 

    GeneLoc Exon Structure

    Selected Alternative Splicing Database (ASD) splice patterns (SP) for YAF2 (see all 7)    About this scheme

    ExUns: 1a · 1b ^ 2a · 2b ^ 3 ^ 4 ^ 5a · 5b · 5c ^ 6 ^ 7 ^ 8
    SP1:              -           -     -     -                 -     -         
    SP2:                                                                        
    SP3:              -           -     -     -     -     -     -     -         
    SP4:              -           -                                             
    SP5:                                                              -         


    ECgene alternative splicing isoforms for YAF2

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    YAF2 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: TGGTAATGTA
    YAF2 Expression
    About this image


    YAF2 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 8) fully expand
     
     Brain (Nervous System)    fully expand to see all 4 entries
             Cerebral Cortex
     
     Ovary (Reproductive System)    fully expand to see all 2 entries
             Ovarian Mesenchymal Stroma Cells Ovary Interstitium
             Oviduct
     
     Neural Ectoderm (Nervous System)
             Neural ectoderm cells
     
     Bone (Muscoskeletal System)
             Bone Marrow
     
     Neural Tube (Nervous System)
             Floor plate-like cells
    YAF2 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    YAF2 Protein Expression
        Pathway & Disease-focused RT2 Profiler PCR Array including YAF2: 
              Polycomb & Trithorax Complexes in human mouse rat

    Primer
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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for YAF2

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of animals.

    Orthologs for YAF2 gene from Selected species (see all 13)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Yaf25 YY1 associated factor 2   --   15 (47.39 cM) 93284278 
    chicken
    (Gallus gallus)
    Aves YAF26
    Gallus gallus YY1 associated factor 2 (YAF2), mRNA...
    99(a)
    1 ↔ 1
    1(29454858-29481796)
    lizard
    (Anolis carolinensis)
    Reptilia YAF26
    YY1 associated factor 2
    98(a)
    1 ↔ 1
    5(55315245-55352809)
    African clawed frog
    (Xenopus laevis)
    Amphibia Xl.217742 Xenopus laevis transcribed sequence with moderate similarity more 85.69(n)    BJ093210.1 
    zebrafish
    (Danio rerio)
    Actinopterygii yaf26
    YY1 associated factor 2
    77(a)
    1 ↔ 1
    4(12970046-12985730) ENSDARG00000015966
    fruit fly
    (Drosophila melanogaster)
    Insecta RYBP6
    Ring and YY1 Binding Protein
    51(a)
    1 → many
    2R(18558257-18560717)


    ENSEMBL Gene Tree for YAF2 (if available)
    TreeFam Gene Tree for YAF2 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for YAF2 gene
    RYBP2  
    1 SIMAP similar gene for YAF2 using alignment to 9 protein entries:     YAF2_HUMAN (see all proteins):
    RYBP

    Find genes that share paralogs with YAF2           About GenesLikeMe


    1 Pseudogenes.org Pseudogene for YAF2
    PGOHUM00000262036


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for YAF2 (see all 1602)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 12 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs124251061,2
    C,F,H--42550443(+) TGCCTG/ATGATA 4 -- ds50015Minor allele frequency- A:0.01NS EA NA 540
    rs583691301,2
    C,F--42550546(+) TGTAAC/TCTTGT 4 -- ds50011Minor allele frequency- T:0.04WA 118
    rs128219241,2
    H--42550569(+) ATCAGT/GGATTT 4 -- ds50014Minor allele frequency- G:0.00NS EA 418
    rs7121101,2
    F--42550598(-) AAGAAA/TTTCAG 4 -- ds50013Minor allele frequency- T:0.03NA WA 122
    rs128220901,2
    H--42550625(+) CTTTGT/GTCCAG 4 -- ds50014Minor allele frequency- G:0.00NS EA 418
    rs1840706341,2
    --42550686(+) CAAAGC/TGTTCT 4 -- ds50010--------
    rs1382623471,2
    --42550712(+) CTTACA/GTACGC 4 -- ds50010--------
    rs1496273801,2
    --42550759(+) AGTGCA/GGAAAC 4 -- ds50010--------
    rs111813541,2
    C,F,H--42550839(+) AGTAGC/GAGAGC 4 -- ds50016Minor allele frequency- G:0.06NS EA CSA NA 533
    rs340142271,2
    C--42550865(+) TCCAC-/TTTTTT 4 -- ds50013Minor allele frequency- T:0.17NA CSA 6

    HapMap Linkage Disequilibrium report for YAF2 (42550906 - 42632154 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 2 variations for YAF2:    About this table    
    Variant IDTypeSubtypePubMed ID
    nsv437751CNV Loss16327808
    dgv287n67CNV Gain20364138

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing YAF2
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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 607534    OMIM disorders: --


    Find genes that share disorders with YAF2           About GenesLikeMe

    Genetic Association Database (GAD): YAF2
    Human Genome Epidemiology (HuGE) Navigator: YAF2 (2 documents)

    Export disorders for YAF2 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for YAF2 gene, integrated from 10 sources (see all 23):
    (articles sorted by number of sources associating them with YAF2)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Yeast two-hybrid cloning of a novel zinc finger protein that interacts with the multifunctional transcription factor YY1. (PubMed id 9016636)1, 2, 3, 9 Kalenik J.L.... Lee T.-C. (Nucleic Acids Res. 1997)
    2. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PubMed id 20379614)1, 4 Rose J.E....Uhl G.R. (Mol. Med. 2010)
    3. Coeliac disease-associated risk variants in TNFAIP3 and REL implicate altered NF-kappaB signalling. (PubMed id 19240061)1, 4 Trynka G....Wijmenga C. (Gut 2009)
    4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    5. Yaf2 inhibits Myc biological function. (PubMed id 12706874)1, 2 Maedge B.... Schwab M. (Cancer Lett. 2003)
    6. A complex with chromatin modifiers that occupies E2F- and Myc- responsive genes in G0 cells. (PubMed id 12004135)1, 2 Ogawa H.... Nakatani Y. (Science 2002)
    7. Functional interaction of Yaf2 with the central region of MycN. (PubMed id 11593398)1, 2 Bannasch D.... Schwab M. (Oncogene 2001)
    8. Interlaboratory reproducibility of large-scale human protein-complex analysis by standardized AP-MS. (PubMed id 23455922)1 Varjosalo M....Superti-Furga G. (Nat. Methods 2013)
    9. Systems-wide analysis of ubiquitylation dynamics reveals a key role for PAF15 ubiquitylation in DNA-damage bypass. (PubMed id 23000965)1 Povlsen L.K....Choudhary C. (Nat. Cell Biol. 2012)
    10. PCGF homologs, CBX proteins, and RYBP define functionally distinct PRC1 family complexes. (PubMed id 22325352)1 Gao Z....Reinberg D. (Mol. Cell 2012)

    (in PubMed, OMIM, and NCBI Bookshelf)
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    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 10138 HGNC: 17363 AceView: YAF2 Ensembl:ENSG00000015153 euGenes: HUgn10138
    ECgene: YAF2 H-InvDB: YAF2

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for YAF2 Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for YAF2 Genetics and Cytogenetics in Oncology and Haematology

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for YAF2 gene:
    Search GeneIP for patents involving YAF2

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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