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Aliases for YAF2 Gene

Aliases for YAF2 Gene

  • YY1 Associated Factor 2 2 3 5

External Ids for YAF2 Gene

Previous GeneCards Identifiers for YAF2 Gene

  • GC12M042627
  • GC12M042453
  • GC12M042269
  • GC12M040839
  • GC12M042550
  • GC12M039578

Summaries for YAF2 Gene

Entrez Gene Summary for YAF2 Gene

  • This gene encodes a zinc finger containing protein that functions in the regulation of transcription. This protein was identified as an interacting partner of transcriptional repressor protein Yy1, and also interacts with other transcriptional regulators, including Myc and Polycomb. This protein can promote proteolysis of Yy1. Multiple alternatively spliced transcript variants have been found. [provided by RefSeq, Feb 2016]

GeneCards Summary for YAF2 Gene

YAF2 (YY1 Associated Factor 2) is a Protein Coding gene. Diseases associated with YAF2 include Facioscapulohumeral Muscular Dystrophy 1. GO annotations related to this gene include transcription coactivator activity and transcription corepressor activity. An important paralog of this gene is RYBP.

UniProtKB/Swiss-Prot for YAF2 Gene

  • Binds to MYC and inhibits MYC-mediated transactivation. Also binds to MYCN and enhances MYCN-dependent transcriptional activation. Increases calpain 2-mediated proteolysis of YY1 in vitro. Component of the E2F6.com-1 complex, a repressive complex that methylates Lys-9 of histone H3, suggesting that it is involved in chromatin-remodeling.

Gene Wiki entry for YAF2 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for YAF2 Gene

Genomics for YAF2 Gene

Regulatory Elements for YAF2 Gene

Enhancers for YAF2 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH12F042324 1.1 ENCODE 11.3 -88.0 -87979 3.1 ARID4B SIN3A DMAP1 ZNF2 YY1 SLC30A9 FOS SP3 SP5 ZHX2 ENSG00000257225 ZCRB1 ENSG00000252917 GXYLT1 YAF2
GH12F042129 1 Ensembl ENCODE 10.6 +107.6 107563 1.7 CTCF JUN RAD21 GATA3 FOS FOSL2 ZNF654 ZNF362 TEAD1 GFI1B ENSG00000257225 GXYLT1 YAF2 LOC101929308
GH12F042480 1 ENCODE 9.7 -245.4 -245389 5.6 FEZF1 ZNF48 ZNF2 GLIS2 ZNF143 SP3 REST MEF2D CBX8 ZNF610 ENSG00000257225 RNU6-249P YAF2 ENSG00000258068
GH12F042125 0.9 Ensembl ENCODE 10.2 +112.7 112652 1.4 KLF1 ZNF362 CEBPB FEZF1 ZIC2 OSR2 PBX2 PRDM1 ZNF18 GXYLT1 YAF2 ZCRB1 LOC101929308
GH12F042130 0.7 ENCODE 10.6 +108.6 108559 0.2 CTCF ZNF654 TEAD1 REST RAD21 POLR2H GATA3 MYNN SMC3 ZXDB YAF2 GXYLT1 LOC101929308
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around YAF2 on UCSC Golden Path with GeneCards custom track

Promoters for YAF2 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000429283 652 3001 PKNOX1 ARID4B SIN3A FEZF1 DMAP1 ZNF2 ZNF263 SP3 SP5 NFYC

Genomic Location for YAF2 Gene

Chromosome:
12
Start:
42,157,104 bp from pter
End:
42,238,352 bp from pter
Size:
81,249 bases
Orientation:
Minus strand

Genomic View for YAF2 Gene

Genes around YAF2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
YAF2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for YAF2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for YAF2 Gene

Proteins for YAF2 Gene

  • Protein details for YAF2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8IY57-YAF2_HUMAN
    Recommended name:
    YY1-associated factor 2
    Protein Accession:
    Q8IY57
    Secondary Accessions:
    • A8K5P0
    • B4DFU3
    • G3V465
    • Q99710

    Protein attributes for YAF2 Gene

    Size:
    180 amino acids
    Molecular mass:
    19901 Da
    Quaternary structure:
    • Interacts with MYC, MYCN, RNF2/RING1B and YY1. Part of the E2F6.com-1 complex in G0 phase composed of E2F6, MGA, MAX, TFDP1, CBX3, BAT8, EUHMTASE1, RING1, RNF2, MBLR, L3MBTL2 and YAF2.

    Three dimensional structures from OCA and Proteopedia for YAF2 Gene

    Alternative splice isoforms for YAF2 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for YAF2 Gene

Post-translational modifications for YAF2 Gene

  • Ubiquitination at Lys 38
  • Modification sites at PhosphoSitePlus

No data available for DME Specific Peptides for YAF2 Gene

Domains & Families for YAF2 Gene

Gene Families for YAF2 Gene

Protein Domains for YAF2 Gene

Suggested Antigen Peptide Sequences for YAF2 Gene

Graphical View of Domain Structure for InterPro Entry

Q8IY57

UniProtKB/Swiss-Prot:

YAF2_HUMAN :
  • Contains 1 RanBP2-type zinc finger.
Similarity:
  • Contains 1 RanBP2-type zinc finger.
genes like me logo Genes that share domains with YAF2: view

Function for YAF2 Gene

Molecular function for YAF2 Gene

UniProtKB/Swiss-Prot Function:
Binds to MYC and inhibits MYC-mediated transactivation. Also binds to MYCN and enhances MYCN-dependent transcriptional activation. Increases calpain 2-mediated proteolysis of YY1 in vitro. Component of the E2F6.com-1 complex, a repressive complex that methylates Lys-9 of histone H3, suggesting that it is involved in chromatin-remodeling.

Gene Ontology (GO) - Molecular Function for YAF2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003713 transcription coactivator activity IDA 11593398
GO:0003714 transcription corepressor activity IDA 12706874
GO:0005515 protein binding IPI 9016636
GO:0008270 zinc ion binding IEA --
GO:0046872 metal ion binding IEA --
genes like me logo Genes that share ontologies with YAF2: view
genes like me logo Genes that share phenotypes with YAF2: view

Animal Model Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for YAF2 Gene

Localization for YAF2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for YAF2 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for YAF2 gene
Compartment Confidence
nucleus 5
cytosol 5

Gene Ontology (GO) - Cellular Components for YAF2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IEA,IDA 11593398
GO:0005654 nucleoplasm IDA --
GO:0005737 cytoplasm IDA --
genes like me logo Genes that share ontologies with YAF2: view

Pathways & Interactions for YAF2 Gene

No Data Available

Gene Ontology (GO) - Biological Process for YAF2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006351 transcription, DNA-templated IEA --
GO:0006355 regulation of transcription, DNA-templated IEA --
GO:0045892 negative regulation of transcription, DNA-templated IDA 12706874
GO:0045893 positive regulation of transcription, DNA-templated IDA 11593398
genes like me logo Genes that share ontologies with YAF2: view

No data available for Pathways by source and SIGNOR curated interactions for YAF2 Gene

Transcripts for YAF2 Gene

Unigene Clusters for YAF2 Gene

YY1 associated factor 2:
Representative Sequences:

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for YAF2 Gene

ExUns: 1a · 1b ^ 2a · 2b ^ 3 ^ 4 ^ 5a · 5b · 5c ^ 6 ^ 7 ^ 8
SP1: - - - - - -
SP2:
SP3: - - - - - - - -
SP4: - -
SP5: -
SP6: -
SP7: - - - - - -

Relevant External Links for YAF2 Gene

GeneLoc Exon Structure for
YAF2
ECgene alternative splicing isoforms for
YAF2

Expression for YAF2 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for YAF2 Gene

Protein differential expression in normal tissues from HIPED for YAF2 Gene

This gene is overexpressed in Monocytes (22.5), NK cells (6.9), Blymphocyte (6.5), and CD4 Tcells (6.5).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for YAF2 Gene



Protein tissue co-expression partners for YAF2 Gene

NURSA nuclear receptor signaling pathways regulating expression of YAF2 Gene:

YAF2

SOURCE GeneReport for Unigene cluster for YAF2 Gene:

Hs.708084
genes like me logo Genes that share expression patterns with YAF2: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for YAF2 Gene

Orthologs for YAF2 Gene

This gene was present in the common ancestor of animals.

Orthologs for YAF2 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia YAF2 34 35
  • 100 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia YAF2 35
  • 99 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia YAF2 35
  • 98 (a)
OneToOne
dog
(Canis familiaris)
Mammalia YAF2 34 35
  • 97.62 (n)
cow
(Bos Taurus)
Mammalia YAF2 35
  • 97 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Yaf2 35
  • 92 (a)
OneToOne
chicken
(Gallus gallus)
Aves YAF2 35
  • 99 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia YAF2 35
  • 98 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia MGC75686 34
African clawed frog
(Xenopus laevis)
Amphibia Xl.21774 34
zebrafish
(Danio rerio)
Actinopterygii yaf2 35
  • 77 (a)
OneToOne
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.1923 34
fruit fly
(Drosophila melanogaster)
Insecta RYBP 35
  • 51 (a)
OneToMany
Species where no ortholog for YAF2 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for YAF2 Gene

ENSEMBL:
Gene Tree for YAF2 (if available)
TreeFam:
Gene Tree for YAF2 (if available)

Paralogs for YAF2 Gene

Paralogs for YAF2 Gene

(1) SIMAP similar genes for YAF2 Gene using alignment to 9 proteins:

genes like me logo Genes that share paralogs with YAF2: view

Variants for YAF2 Gene

Sequence variations from dbSNP and Humsavar for YAF2 Gene

SNP ID Clin Chr 12 pos Sequence Context AA Info Type
rs10083090 -- 42,234,921(+) agttc(A/G)aggct intron-variant, utr-variant-3-prime
rs10160853 -- 42,216,042(+) GGGAT(G/T)TTTTG intron-variant
rs10459290 -- 42,219,488(+) GTTCA(G/T)TAAGC intron-variant
rs10492386 -- 42,196,422(+) TGAAA(C/T)GATTT intron-variant
rs10492387 -- 42,197,093(+) AAAAT(C/T)AGTGT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for YAF2 Gene

Variant ID Type Subtype PubMed ID
nsv973057 CNV duplication 23825009
nsv437751 CNV loss 16327808
dgv287n67 CNV gain 20364138

Variation tolerance for YAF2 Gene

Residual Variation Intolerance Score: 43.8% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.02; 0.56% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for YAF2 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
YAF2

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for YAF2 Gene

Disorders for YAF2 Gene

MalaCards: The human disease database

(1) MalaCards diseases for YAF2 Gene - From: DISEASES

Disorder Aliases PubMed IDs
facioscapulohumeral muscular dystrophy 1
  • facioscapulohumeral muscular dystrophy
- elite association - COSMIC cancer census association via MalaCards
Search YAF2 in MalaCards View complete list of genes associated with diseases

Relevant External Links for YAF2

Genetic Association Database (GAD)
YAF2
Human Genome Epidemiology (HuGE) Navigator
YAF2
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
YAF2
genes like me logo Genes that share disorders with YAF2: view

No data available for UniProtKB/Swiss-Prot and Genatlas for YAF2 Gene

Publications for YAF2 Gene

  1. Yeast two-hybrid cloning of a novel zinc finger protein that interacts with the multifunctional transcription factor YY1. (PMID: 9016636) Kalenik J.L. … Lee T.-C. (Nucleic Acids Res. 1997) 2 3 4 22 64
  2. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose J.E. … Uhl G.R. (Mol. Med. 2010) 3 46 64
  3. Coeliac disease-associated risk variants in TNFAIP3 and REL implicate altered NF-kappaB signalling. (PMID: 19240061) Trynka G. … Wijmenga C. (Gut 2009) 3 46 64
  4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4 64
  5. Yaf2 inhibits Myc biological function. (PMID: 12706874) Maedge B. … Schwab M. (Cancer Lett. 2003) 3 4 64

Products for YAF2 Gene

Sources for YAF2 Gene

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