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Aliases & Descriptions for YAF2
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc
, and/or 7Ensembl,
8miRBase) About This Section
|
| | | Descriptions |
|---|
| YY1 associated factor 2 2 |
|
| | Search outside databases for aliases for YAF2 genePrevious GC identifers: GC12M042627 GC12M042453 GC12M042269 |
Summaries for YAF2(According to Entrez Gene,
Wikipedia's
Gene Wiki,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
| EntrezGene summary for YAF2: The protein encoded by this gene interacts with YY1, a zinc finger protein involved in negative regulation of muscle-restricted genes. This gene product itself contains a single N-terminal C2-X10-C2 zinc finger, and in contrast to YY1, is up-regulated during myogenic differentiation. It also facilitates proteolytic cleavage of YY1 by the calcium- activated protease, m-calpain, suggesting a mechanism by which this protein antagonizes the negative effect of YY1. [provided by RefSeq] UniProtKB/Swiss-Prot: YAF2_HUMAN, Q8IY57Function: Binds to MYC and inhibits MYC-mediated transactivation. Also binds to MYCN and enhances MYCN-dependent transcriptional activation. Increases calpain 2-mediated proteolysis of YY1 in vitro. Component of the E2F6.com-1 complex, a repressive complex that methylates 'Lys-9' of histone H3, suggesting that it is involved in chromatin-remodelingGene Wiki entry for YAF2 |
Genomic Location for YAF2
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 36),
and/or miRBase,
Genomic Views according to
UCSC and
Ensembl,
Transcription factor binding sites according to
SABiosciences) About This Section
| Genomic View: UCSC Golden Path with GeneCards custom track
Transcription factor binding sites upstream to the YAF2 gene 
Entrez Gene cytogenetic band: 12q12 Ensembl cytogenetic band: 12q12 HGNC cytogenetic band: 12q12YAF2 Gene in genomic location: bands according to Ensembl, locations according to
(and/or Entrez Gene and/or Ensembl if different)
 GeneLoc gene densities for chromosome 12 GeneLoc Exon Structure GeneLoc location for GC12M040839:
(about GC identifiers)
Start:
|
40,837,173 bp from pter |
End:
|
40,918,317 bp from pter |
Size:
|
81,145 bases |
Orientation:
|
minus strand |
RefSeq DNA sequence:- NC_000012.10 NT_029419.11
| Proteins for YAF2
(According to
1UniProtKB,
and/or Ensembl,
Phosphorylation sites according to 2Phosphosite,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from Invitrogen,
Millipore,
Sigma-Aldrich,
R&D Systems,
Enzo Life Sciences,
Abnova,
OriGene and/or,
Abcam,
Biochemical Assays by
Invitrogen,
Millipore,
R&D Systems,
Cell Signaling Technology, and/or
Enzo Life Sciences,
Ontologies according to Gene
Ontology Consortium 01 Apr 2009 and
Entrez Gene,
Antibodies by Invitrogen,
Millipore,
Sigma-Aldrich,
R&D Systems,
Cell Signaling Technology,
Abcam,
Abnova, and/or
Novus Biologicals)
About This Section
| UniProtKB/Swiss-Prot: YAF2_HUMAN, Q8IY57 (See
protein sequence)Recommended Name: YY1-associated factor 2 Size: 180 amino acids; 19901 Da
Subunit: Interacts with MYC, MYCN, RNF2/RING1B and YY1. Part of the E2F6.com-1 complex in G0 phase composed of E2F6, MGA, MAX, TFDP1, CBX3, BAT8, EUHMTASE1, RING1, RNF2, MBLR, L3MBTL2 and YAF2
Subcellular location: Nucleus
PDB structures from and Proteopedia :2D9G (3D)
 
Secondary accessions: Q99710Alternative splicing: 2 isoforms: Q8IY57-1 Q8IY57-2 Post-translational modifications:
Phosphorylated upon DNA damage, probably by ATM or ATR1
View phosphorylation sites using PhosphoSite2
REFSEQ proteins: NP_005739.2
ENSEMBL proteins: ENSP00000370165 ENSP00000328004 ENSP00000370167
Human Recombinant Proteins Browse Origene for full length recombinant human proteins expressed in human HEK293 cells 
2 Gene Ontology (GO) cellular component terms (links to tree view): About this table
Antibodies for YAF2: Assays for YAF2: | Protein
Domains/ Families for YAF2(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
| - Graphical View of Domain Structure for InterPro Entry Q8IY57
ProtoNet protein and cluster: Q8IY57 1 Blocks protein family: IPB001876 Zn-finger
UniProtKB/Swiss-Prot: YAF2_HUMAN, Q8IY57Similarity: Contains 1 RanBP2-type zinc finger | Gene Function for YAF2
(According to MGI Jun 06 2009, UniProtKB,
IUBMB,and/or Genatlas,
shRNA from
OriGene,
Sigma-Aldrich, RNAi from
Sigma-Aldrich,
RNAi Products,
Clones, and
Q-PCR Products
from Invitrogen,
Millipore,
OriGene, and/or
Abnova,
siRNAs from
Applied Biosystems,
SYBR primers from OriGene,
Cell-based Assays from Millipore,
Ontologies according to Gene Ontology Consortium 01 Apr 2009 via
Entrez Gene.)
About This Section
|                OriGene 29mer shRNA kit in GFP-retroviral vectors (see all 2): NM_005748
Applied Biosystems Silencer® siRNAs for YAF2
Sigma-Aldrich siRNA for YAF2  Sigma-Aldrich shRNA for YAF2  Explore Sigma-Aldrich super-pooled esiRNAs 
              OriGene GFP tagged cDNA clone in CMV expression vector: NM_005748                                  Myc/DDK tagged cDNA clone in CMV expression vector: NM_005748                                  untagged cDNA clones in CMV expression vector (see all 2): NM_001012424 
Primers: Browse
Quantitative PCR Central at Invitrogen for Q-PCR LUX™ Primers               OriGene genome-wide validated SYBR primer pairs: NM_005748
UniProtKB/Swiss-Prot: YAF2_HUMAN, Q8IY57Function: Binds to MYC and inhibits MYC-mediated transactivation. Also binds to MYCN and enhances MYCN-dependent transcriptional activation. Increases calpain 2-mediated proteolysis of YY1 in vitro. Component of the E2F6.com-1 complex, a repressive complex that methylates 'Lys-9' of histone H3, suggesting that it is involved in chromatin-remodeling5 Gene Ontology (GO) molecular function terms (links to tree view): About this table | Pathways & Interactions for YAF2
(Pathways according to Invitrogen
(maps by GeneGo),
Millipore,
Cell Signaling Technology,
Sigma-Aldrich,
KEGG
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Proteins Network according to
SABiosciences,
Interactions according to 1UniProtKB,
2MINT, and/or
3STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Apr 2009 via
Entrez Gene.)
About This Section
|
Gene Network CentralTM Interacting Genes and Proteins Network for YAF2 
5 Interacting proteins for YAF2 (Q8IY572 ENSP000003280043) via UniProtKB, MINT, and/or STRINGAbout this table
3 Gene Ontology (GO) biological process terms (links to tree view): About this table
|
Drugs & Compounds for YAF2(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
Sigma-Aldrich, Tocris Bioscience, and/or
Novoseek and Drugs according to
Enzo Life Sciences and/or
PharmGKB)
About This Section
|
Browse Tocris compounds for YAF2
|
Transcripts for YAF2(GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 219 Homo sapiens; Jun 2 2009) or GenBank, RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
non coding RNAs according to
RNAdb,
ESTs according to GeneTide,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from Invitrogen,
Millipore, and/or
Abnova,
siRNAs from Applied Biosystems,
Sigma-Aldrich,
shRNA from
Sigma-Aldrich,
OriGene,
Tagged/untagged cDNA clones from
OriGene, Expression Assays from Applied Biosystems) About This Section
|                OriGene 29mer shRNA kit in GFP-retroviral vectors (see all 2): NM_005748
Sigma-Aldrich siRNA for YAF2  Sigma-Aldrich shRNA for YAF2  Explore Sigma-Aldrich super-pooled esiRNAs 
Applied Biosystems Silencer® siRNAs: NM_005748 REFSEQ mRNAs for YAF2 gene: NM_005748.3
Applied Biosystems TaqMan ® Gene Expression Assays: NM_005748               OriGene GFP tagged cDNA clone in CMV expression vector: NM_005748                                  Myc/DDK tagged cDNA clone in CMV expression vector: NM_005748                                  untagged cDNA clones in CMV expression vector (see all 2): NM_001012424  Additional cDNA sequence: AK127531.1 AK291355.1 AK294260.1 AK296191.1 BC037777.2 BX649019.1 15 DOTS entries: DT.100713349 DT.95370291 DT.311602 DT.100785008 DT.95165738 DT.95193729 DT.91955631 DT.100718765 DT.121192305 DT.121192450 DT.87017814 DT.121192299 DT.95165737 DT.97837659 DT.91658529 24/116 AceView cDNA sequences (see all 116
):BF477716 BX099756 AA384399 BU170747 BU541658 AI655607 BM023254 AA765439 AA568443 BM068838 Z39046 BP375794 F06147 BU543113 BM995328 F10745 BU619569 AW073893 BX649019 AI285403 AI078329 BE894451 AI743991 CK904670
highest scoring ESTs for YAF2:U72209 AA385199 AA568443 AA765439 AA804610 AI655607 AL135153 AU135339 AU137455 AU279420 Unigene Cluster for YAF2: YY1 associated factor 2 Hs.708084 [show with all ESTs]Unigene Representative Sequence: AK127531
GeneLoc Exon Structure
5/7 Alternative Splicing Database (ASD) splice patterns (SP) for YAF2 (see all 7
)
| ExUns: | 1a | · | 1b | ^ | 2a | · | 2b | ^ | 3 | ^ | 4 | ^ | 5a | · | 5b | · | 5c | ^ | 6 | ^ | 7 | ^ | 8 | |
| SP1: | |   | |   | - |   | |   | - |   | - |   | - |   | |   | |   | - |   | - |   | |   | |
| SP2: | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |
| SP3: | |   | |   | - |   | |   | - |   | - |   | - |   | - |   | - |   | - |   | - |   | |   | |
| SP4: | |   | |   | - |   | |   | - |   | |   | |   | |   | |   | |   | |   | |   | |
| SP5: | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | - |   | |   |
About this scheme
ECgene alternative splicing isoforms for YAF2
3 Ensembl transcripts including schematic representations: ENST00000380788
ENST00000327791
ENST00000380790
|
Expression for YAF2
(Experimental results according to
1GeneNote
and GNF BioGPS,
probe sets-to-genes annotations according to
2GeneAnnot ,
3GeneTide ,
Sets of similar genes according to GeneDecks,
Electronic Northern calculations according to data from
UniGene (Build 219 Homo sapiens),
SAGE tags according to
CGAP,
plus additional links to
SOURCE, and/or
GNF
BioGPS, and/or
EXPOLDB, and/or
UniProtKB,
Expression Assays from
Applied Biosystems
)
About This Section
| YAF2 expression in normal and diseased human tissues
Applied Biosystems TaqMan ® Gene Expression Assays for YAF2
1 / 2 / 3 9 probe-sets matching YAF2 gene Data from
(Publications) and GNF BioGPS About these images About these images
CGAP SAGE TAG: TGGTAATGTA
SOURCE GeneReport for Unigene cluster: Hs.708084
Expression variation in blood from EXPOLDB for YAF2 |
Orthologs for YAF2
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
and/or
5MGI Jun 06 2009,
with possible further links to
Flybase
and/or
WormBase,
Gene Trees according to Ensembl)
About This Section
|
Orthologs for YAF2 gene from 5/10 species (see all 10
)
About this table Species with no ortholog for YAF2
ENSEMBL Gene Tree for YAF2 | Paralogs for YAF2(Paralogs according to 1HomoloGene and 2Ensembl, Pseudogenes according to 3Pseudogene.org) About This Section
| Paralogs for YAF2 gene
- RYBP2
|
SNPs/Variants for YAF2(According to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE, and
UniProtKB,
Linkage Disequilibrium by HapMap,
Genotyping Reagents from
Applied Biosystems)
About This Section
|
HapMap Linkage Disequilibrium images for YAF2 (up to first 250kb)
|
Disorders & Mutations for YAF2
(in which this Gene is Involved, According to
OMIM, UniProtKB,
PharmGKB,
Genatlas, GeneTests,
Blood group antigen gene mutations by BGMUT,
HGMD, GAD,
HuGE Navigator,
BCGD,
and/or TGDB.)
About This Section
|
OMIM: 607534
Human Genome Epidemiology Navigator: YAF2 (1 document)
|
Medical News for YAF2(Possibly Related Articles in
Doctor's Guide)
About This Section
| -- |
Publications for YAF2 (in
PubMed.
Associations of this gene to articles via
1Novoseek,
2HGNC,
3Entrez Gene,
4UniProtKB/Swiss-Prot,
5UniProtKB/TrEMBL,
6GAD, and/or
7PharmGKB)
About This Section
| 10/12 PubMed articles for YAF2 gene (see all 12
):- Yeast two-hybrid cloning of a novel zinc finger protein that interacts with the multifunctional transcription factor YY1. (PubMed id 9016636)1, 2, 3, 4 Kalenik J.L.... Lee T.-C. (1997)
- Global, in vivo, and site-specific phosphorylation dynamics in signaling networks. (PubMed id 17081983)3, 4 Olsen J.V....Mann M. (2006)
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)3, 4 Gerhard D.S....Malek J. (2004)
- Yaf2 inhibits Myc biological function. (PubMed id 12706874)3, 4 Maedge B.... Schwab M. (2003)
- A complex with chromatin modifiers that occupies E2F- and Myc-responsive genes in G0 cells. (PubMed id 12004135)3, 4 Ogawa H....Nakatani Y. (2002)
- Functional interaction of Yaf2 with the central region of MycN. (PubMed id 11593398)3, 4 Bannasch D.... Schwab M. (2001)
- Coeliac disease associated risk variants in TNFAIP3 and REL implicate altered NF-{kappa}B signalling. (PubMed id 19240061)3 Trynka G....Wijmenga C. (2009)
- A quantitative atlas of mitotic phosphorylation. (PubMed id 18669648)4 Dephoure N.... Gygi S.P. (2008)
- ATM and ATR substrate analysis reveals extensive protein networks responsive to DNA damage. (PubMed id 17525332)4 Matsuoka S.... Elledge S.J. (2007)
- The finished DNA sequence of human chromosome 12. (PubMed id 16541075)4 Scherer S.E.... Gibbs R.A. (2006)
|
Search for YAF2
(in PubMed,
OMIM, and NCBI Bookshelf) About This Section
|
|
Genome Databases showing YAF2
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
and/or
H-InvDB)
About This Section
|
| Other Databases showing YAF2
(According to HUGE)
About This Section
| -- |
Specialized Databases showing YAF2(According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL, Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot) About This Section
|
| About This Section
| --
| Services for YAF2(Reagents available from Applied Biosystems, Antibodies and assays by Cell
Signaling Technology, Abcam, Novus Biologicals, Sigma-Aldrich, R&D Systems, Millipore, Abnova, and/or Invitrogen, Clones available from OriGene,and/or Invitrogen, Drugs and/or compounds by Sigma-Aldrich, Enzo Life Sciences, and/or Tocris Bioscience) About This Section
| 
 Products for YAF2:

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Incremental update: 13 Oct 2009
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