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Aliases for YAF2 Gene

Aliases for YAF2 Gene

  • YY1 Associated Factor 2 2 3

External Ids for YAF2 Gene

Previous GeneCards Identifiers for YAF2 Gene

  • GC12M042627
  • GC12M042453
  • GC12M042269
  • GC12M040839
  • GC12M042550
  • GC12M039578

Summaries for YAF2 Gene

Entrez Gene Summary for YAF2 Gene

  • The protein encoded by this gene interacts with YY1, a zinc finger protein involved in negative regulation of muscle-restricted genes. This gene product itself contains a single N-terminal C2-X10-C2 zinc finger, and in contrast to YY1, is up-regulated during myogenic differentiation. It also facilitates proteolytic cleavage of YY1 by the calcium- activated protease, m-calpain, suggesting a mechanism by which this protein antagonizes the negative effect of YY1. Multiple alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Jul 2010]

GeneCards Summary for YAF2 Gene

YAF2 (YY1 Associated Factor 2) is a Protein Coding gene. GO annotations related to this gene include transcription coactivator activity and transcription corepressor activity. An important paralog of this gene is RYBP.

UniProtKB/Swiss-Prot for YAF2 Gene

  • Binds to MYC and inhibits MYC-mediated transactivation. Also binds to MYCN and enhances MYCN-dependent transcriptional activation. Increases calpain 2-mediated proteolysis of YY1 in vitro. Component of the E2F6.com-1 complex, a repressive complex that methylates Lys-9 of histone H3, suggesting that it is involved in chromatin-remodeling.

Gene Wiki entry for YAF2 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for YAF2 Gene

Genomics for YAF2 Gene

Regulatory Elements for YAF2 Gene

Genomic Location for YAF2 Gene

Start:
42,157,104 bp from pter
End:
42,238,352 bp from pter
Size:
81,249 bases
Orientation:
Minus strand

Genomic View for YAF2 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for YAF2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for YAF2 Gene

Proteins for YAF2 Gene

  • Protein details for YAF2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8IY57-YAF2_HUMAN
    Recommended name:
    YY1-associated factor 2
    Protein Accession:
    Q8IY57
    Secondary Accessions:
    • A8K5P0
    • B4DFU3
    • G3V465
    • Q99710

    Protein attributes for YAF2 Gene

    Size:
    180 amino acids
    Molecular mass:
    19901 Da
    Quaternary structure:
    • Interacts with MYC, MYCN, RNF2/RING1B and YY1. Part of the E2F6.com-1 complex in G0 phase composed of E2F6, MGA, MAX, TFDP1, CBX3, BAT8, EUHMTASE1, RING1, RNF2, MBLR, L3MBTL2 and YAF2.

    Three dimensional structures from OCA and Proteopedia for YAF2 Gene

    Alternative splice isoforms for YAF2 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for YAF2 Gene

Proteomics data for YAF2 Gene at MOPED

Post-translational modifications for YAF2 Gene

  • Ubiquitination at Lys38
  • Modification sites at PhosphoSitePlus

Antibody Products

No data available for DME Specific Peptides for YAF2 Gene

Domains for YAF2 Gene

Protein Domains for YAF2 Gene

InterPro:
Blocks:
ProtoNet:

Suggested Antigen Peptide Sequences for YAF2 Gene

Graphical View of Domain Structure for InterPro Entry

Q8IY57

UniProtKB/Swiss-Prot:

YAF2_HUMAN :
  • Q8IY57
Similarity:
  • Contains 1 RanBP2-type zinc finger.
genes like me logo Genes that share domains with YAF2: view

No data available for Gene Families for YAF2 Gene

Function for YAF2 Gene

Molecular function for YAF2 Gene

UniProtKB/Swiss-Prot Function:
Binds to MYC and inhibits MYC-mediated transactivation. Also binds to MYCN and enhances MYCN-dependent transcriptional activation. Increases calpain 2-mediated proteolysis of YY1 in vitro. Component of the E2F6.com-1 complex, a repressive complex that methylates Lys-9 of histone H3, suggesting that it is involved in chromatin-remodeling.

Gene Ontology (GO) - Molecular Function for YAF2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003713 transcription coactivator activity IDA 11593398
GO:0003714 transcription corepressor activity IDA 12706874
GO:0005515 protein binding IPI 11593398
GO:0008270 zinc ion binding IEA --
genes like me logo Genes that share ontologies with YAF2: view

Phenotypes for YAF2 Gene

GenomeRNAi human phenotypes for YAF2:
genes like me logo Genes that share phenotypes with YAF2: view

Animal Model Products

miRNA for YAF2 Gene

miRTarBase miRNAs that target YAF2

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for YAF2

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targeting and HOMER Transcription for YAF2 Gene

Localization for YAF2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for YAF2 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for YAF2 Gene COMPARTMENTS Subcellular localization image for YAF2 gene
Compartment Confidence
nucleus 5
cytosol 3

Gene Ontology (GO) - Cellular Components for YAF2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IDA 11593398
GO:0005654 nucleoplasm IDA --
GO:0005737 cytoplasm IDA --
genes like me logo Genes that share ontologies with YAF2: view

Pathways for YAF2 Gene

SuperPathways for YAF2 Gene

No Data Available

PCR Array Products

  • Pathway & Disease-focused RT² Profiler PCR Arrays
    • Polycomb & Trithorax Complexes in human,mouse,rat

Gene Ontology (GO) - Biological Process for YAF2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006351 transcription, DNA-templated IEA --
GO:0045892 negative regulation of transcription, DNA-templated IDA 12706874
GO:0045893 positive regulation of transcription, DNA-templated IDA 11593398
genes like me logo Genes that share ontologies with YAF2: view

No data available for Pathways by source for YAF2 Gene

Transcripts for YAF2 Gene

Unigene Clusters for YAF2 Gene

YY1 associated factor 2:
Representative Sequences:

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for YAF2

Primer Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for YAF2 Gene

ExUns: 1a · 1b ^ 2a · 2b ^ 3 ^ 4 ^ 5a · 5b · 5c ^ 6 ^ 7 ^ 8
SP1: - - - - - -
SP2:
SP3: - - - - - - - -
SP4: - -
SP5: -
SP6: -
SP7: - - - - - -

Relevant External Links for YAF2 Gene

GeneLoc Exon Structure for
YAF2
ECgene alternative splicing isoforms for
YAF2

Expression for YAF2 Gene

mRNA expression in normal human tissues for YAF2 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues for YAF2 Gene

This gene is overexpressed in Monocytes (22.5), NK cells (6.9), Blymphocyte (6.5), and CD4 Tcells (6.5).

Integrated Proteomics: protein expression from ProteomicsDB, MOPED, and MaxQB for YAF2 Gene

SOURCE GeneReport for Unigene cluster for YAF2 Gene Hs.708084

genes like me logo Genes that share expressions with YAF2: view

Expression partners for YAF2 Gene

In Situ Assay Products

No data available for mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for YAF2 Gene

Orthologs for YAF2 Gene

This gene was present in the common ancestor of animals.

Orthologs for YAF2 Gene

Organism Taxonomy Gene Similarity Type Details
dog
(Canis familiaris)
Mammalia YAF2 35
  • 97.62 (n)
  • 98.98 (a)
YAF2 36
  • 99 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia YAF2 35
  • 100 (n)
  • 100 (a)
YAF2 36
  • 100 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Yaf2 16
Yaf2 36
  • 92 (a)
OneToOne
cow
(Bos Taurus)
Mammalia YAF2 36
  • 97 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia YAF2 36
  • 98 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia YAF2 36
  • 99 (a)
OneToOne
chicken
(Gallus gallus)
Aves YAF2 36
  • 99 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia YAF2 36
  • 98 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia MGC75686 35
African clawed frog
(Xenopus laevis)
Amphibia Xl.21774 35
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.1923 35
zebrafish
(Danio rerio)
Actinopterygii yaf2 36
  • 77 (a)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta RYBP 36
  • 51 (a)
OneToMany
Species with no ortholog for YAF2:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for YAF2 Gene

ENSEMBL:
Gene Tree for YAF2 (if available)
TreeFam:
Gene Tree for YAF2 (if available)

Paralogs for YAF2 Gene

Paralogs for YAF2 Gene

Selected SIMAP similar genes for YAF2 Gene using alignment to 9 proteins:

Pseudogenes.org Pseudogenes for YAF2 Gene

genes like me logo Genes that share paralogs with YAF2: view

Variants for YAF2 Gene

Sequence variations from dbSNP and Humsavar for YAF2 Gene

SNP ID Clin Chr 12 pos Sequence Context AA Info Type MAF
rs13404 -- 42,157,168(+) CAGGG(A/T)GCCCA utr-variant-3-prime, nc-transcript-variant
rs289284 -- 42,227,098(+) TTCAG(C/T)GGGCA intron-variant
rs401679 -- 42,227,256(+) cggcc(A/G)ccacc intron-variant
rs701250 -- 42,188,336(+) ATCTT(C/G)TTTGT intron-variant
rs712110 -- 42,156,796(-) AAGAA(A/T)TTCAG downstream-variant-500B

Structural Variations from Database of Genomic Variants (DGV) for YAF2 Gene

Variant ID Type Subtype PubMed ID
dgv287n67 CNV Gain 20364138
nsv437751 CNV Loss 16327808

Relevant External Links for YAF2 Gene

HapMap Linkage Disequilibrium report
YAF2

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for YAF2 Gene

Disorders for YAF2 Gene

Relevant External Links for YAF2

Genetic Association Database (GAD)
YAF2
Human Genome Epidemiology (HuGE) Navigator
YAF2

No disorders were found for YAF2 Gene.

No data available for MalaCards , OMIM , UniProtKB/Swiss-Prot , University of Copenhagen DISEASES , Novoseek inferred disease relationships and Genatlas for YAF2 Gene

Publications for YAF2 Gene

  1. Yeast two-hybrid cloning of a novel zinc finger protein that interacts with the multifunctional transcription factor YY1. (PMID: 9016636) Kalenik J.L. … Lee T.-C. (Nucleic Acids Res. 1997) 2 3 4 23
  2. Functional interaction of Yaf2 with the central region of MycN. (PMID: 11593398) Bannasch D. … Schwab M. (Oncogene 2001) 3 4
  3. A complex with chromatin modifiers that occupies E2F- and Myc- responsive genes in G0 cells. (PMID: 12004135) Ogawa H. … Nakatani Y. (Science 2002) 3 4
  4. Yaf2 inhibits Myc biological function. (PMID: 12706874) Maedge B. … Schwab M. (Cancer Lett. 2003) 3 4
  5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4

Products for YAF2 Gene

Sources for YAF2 Gene

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