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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

YAE1D1 Gene

protein-coding   GIFtS: 37
GCID: GC07P039605

Yae1 Domain Containing 1

(Previous name: chromosome 7 open reading frame 36)
(Previous symbol: C7orf36)
  Search for YAE1D1
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Yae1 Domain Containing 11 2
C7orf361 2 3
Chromosome 7 Open Reading Frame 361
Yae1 Domain-Containing Protein 12

External Ids:    HGNC: 248571   Entrez Gene: 570022   Ensembl: ENSG000002411277   UniProtKB: Q9NRH13   

Export aliases for YAE1D1 gene to outside databases


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

GeneCards Summary for YAE1D1 Gene: 
YAE1D1 (Yae1 domain containing 1) is a protein-coding gene.


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000007.13  NT_007819.17  NC_018918.2  NT_079592.2  
Regulatory elements:
   Search SABiosciences Regulatory transcription factor binding sites for YAE1D1
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 2): YAE1D1 promoter sequence
   Search SABiosciences Chromatin IP Primers for YAE1D1

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat YAE1D1


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 7p14.1   Ensembl cytogenetic band:  7p14.1   HGNC cytogenetic band: 7p14.1

YAE1D1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
YAE1D1 gene location

GeneLoc information about chromosome 7         GeneLoc Exon Structure

GeneLoc location for GC07P039605:  view genomic region     (about GC identifiers)

Start:
39,605,975 bp from pter      End:
39,649,919 bp from pter
Size:
43,945 bases      Orientation:
plus strand

1 alternative location:
Chr7+,CRA_TCAG 39,643,891-39,650,368     

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: YAED1_HUMAN, Q9NRH1 (See protein sequence)
Recommended Name: Yae1 domain-containing protein 1  
Size: 226 amino acids; 25299 Da
Secondary accessions: A4D1W4 Q6IAF7 Q8WVZ5

Explore the universe of human proteins at neXtProt for YAE1D1: NX_Q9NRH1

Explore proteomics data for YAE1D1 at MOPED 

Post-translational modifications:

  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_Q9NRH1

  • YAE1D1 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    YAE1D1 Protein Expression
    REFSEQ proteins (2 alternative transcripts): 
    NP_001269375.1  NP_064577.1  

    ENSEMBL proteins: 
     ENSP00000223273   ENSP00000400511   ENSP00000395777  

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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    1 InterPro protein domain:
     IPR019191 Essential_protein_Yae1_N

    Graphical View of Domain Structure for InterPro Entry Q9NRH1

    ProtoNet protein and cluster: Q9NRH1


    YAE1D1 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Animal Models:
       inGenious Targeting Laboratory - Custom generated mouse model solutions for YAE1D1 
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    Inhib. RNA
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for YAE1D1


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section



    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for YAE1D1

    STRING Interaction Network Preview (showing 5 interactants - click image to see 8)

    5/28 Interacting proteins for YAE1D1 (Q9NRH12, 3 ENSP000002232734) via UniProtKB, MINT, STRING, and/or I2D (see all 28)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    CHD3Q128732, 3MINT-65596 MINT-8250146 I2D: score=5 
    KIAA1377Q9P2H02, 3MINT-65595 MINT-8250198 I2D: score=5 
    VIMP086702, 3MINT-8250264 MINT-65594 I2D: score=5 
    BBS10Q8TAM12, 3, ENSP000003769464MINT-8250123 I2D: score=2 STRING: ENSP00000376946
    TPD52L1Q168902, 3MINT-63147 I2D: score=5 
    About this table

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for YAE1D1 (YAED1)

    Search CenterWatch for drugs/clinical trials and news about YAE1D1 / YAED1

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for YAE1D1 gene (2 alternative transcripts): 
    NM_001282446.1  NM_020192.4  

    Unigene Cluster for YAE1D1:

    Yae1 domain containing 1
    Hs.83313  [show with all ESTs]
    Unigene Representative Sequence: BX648555
    6 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000223273(uc003thc.4) ENST00000474392 ENST00000448268 ENST00000432096
    ENST00000469737 ENST00000485025
    miRNA
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    Search QIAGEN for miScript miRNA Assays for microRNAs that regulate YAE1D1
    SwitchGear 3'UTR luciferase reporter plasmidYAE1D1 3' UTR sequence
    Inhib. RNA
    Products:
         
    Browse for Gene Knock-down Tools from EMD Millipore
    OriGene RNAi products in human, mouse, rat for YAE1D1
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat YAE1D1
    Clone
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    OriGene ORF clones in mouse, rat for YAE1D1
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    GenScript Custom all cDNA clones Services for YAE1D1
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for YAE1D1
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat YAE1D1
    Sirion Biotech Customized lentivirus for stable overexpression of YAE1D1 
                         Customized lentivirus expression plasmids for stable overexpression of YAE1D1 
    Primer
    Products:
        
    OriGene qPCR primer pairs and template standards for YAE1D1
    OriGene qSTAR qPCR primer pairs in human, mouse for YAE1D1
    Search SABiosciences RT2 qPCR Primer Assays in human, mouse, rat YAE1D1
      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat YAE1D1
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat YAE1D1

    Additional mRNA sequence: 

    AF226046.1 AK314937.1 BC022043.1 BX648555.1 CR457198.1 

    6 DOTS entries:

    DT.75176448  DT.102825157  DT.92004255  DT.102825156  DT.75190952  DT.92020758 

    24/83 AceView cDNA sequences (see all 83):

    BG540364 AA664474 CB105339 AF226046 BM850088 BM712319 BM557877 BX113920 
    CA430980 AW069792 BF513701 BM849788 NM_020192 AI627542 AV682608 AI697460 
    BM767075 BG616931 BX648555 BG164287 BE645621 AA150176 BX492887 AA805555 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    YAE1D1 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: GATTTTGGAA
    YAE1D1 Expression
    About this image


    See YAE1D1 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for YAE1D1

    SOURCE GeneReport for Unigene cluster: Hs.83313
        SABiosciences Custom PCR Arrays for YAE1D1
    Primer
    Products:
    OriGene qPCR primer pairs and template standards for YAE1D1
    OriGene qSTAR qPCR primer pairs in human, mouse for YAE1D1
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    QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat YAE1D1
    QIAGEN QuantiFast Probe-based Assays in human, mouse, rat YAE1D1
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for YAE1D1

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of chordates.

    Orthologs for YAE1D1 gene from 5/12 species (see all 12)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Yae1d11 , 5 RIKEN cDNA 1600012F09 gene5
    Yae1 domain containing 11
    79.48(n)1
    70.37(a)1
      13 (6.05 cM)5
    670081  NM_025904.31  NP_080180.11 
     179866405 
    chicken
    (Gallus gallus)
    Aves YAE1D11 Yae1 domain containing 1 60.61(n)
    45.45(a)
      420764  XM_003640729.1  XP_003640777.1 
    lizard
    (Anolis carolinensis)
    Reptilia YAE1D16
    Uncharacterized protein
    46(a)
    1 ↔ 1
    6(48790767-48799155)
    African clawed frog
    (Xenopus laevis)
    Amphibia BG731193.12   -- 69.5(n)    BG731193.1 
    zebrafish
    (Danio rerio)
    Actinopterygii fam105ba1 family with sequence similarity 105, member B, a 48.64(n)
    31.58(a)
      406416  NM_213142.1  NP_998307.1 


    ENSEMBL Gene Tree for YAE1D1 (if available)
    TreeFam Gene Tree for YAE1D1 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
      --

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/226 SNPs in YAE1D1 are shown (see all 226)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 7 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs77859641,2
    C,F--39604064(+) GAGGTT/GGAGGC 1 -- us2k17Minor allele frequency- G:0.18NA WA EA 366
    rs1399961101,2
    C--39604095(+) GGAGAA/TCAAGG 1 -- us2k10--------
    rs1855090791,2
    --39604118(+) GTGATC/TTCACC 1 -- us2k10--------
    rs355450931,2
    C--39604163(+) TGTTTA/TAAAAA 1 -- us2k12Minor allele frequency- T:0.00NA 4
    rs719380511,2
    C--39604163(+) AAAAA-/A/AA  
            
    AAAAA
    1 -- us2k11CSA 2
    rs77862531,2
    C,F,H--39604190(+) TGCAAT/CGAAAT 1 -- us2k19Minor allele frequency- C:0.09NS EA NA WA 516
    rs168800671,2
    C,F--39604227(+) GTTTGC/TTTTCC 1 -- us2k13Minor allele frequency- T:0.01NA 142
    rs1904270441,2
    --39604279(+) CCAGGG/TTGGTG 1 -- us2k10--------
    rs1155708471,2
    C--39604308(+) AATTTC/TGCACC 1 -- us2k10--------
    rs77869291,2
    C,F,A,H--39604670(+) TTTAGT/ATGGTA 1 -- us2k111Minor allele frequency- A:0.09NS EA NA WA CSA 639

    HapMap Linkage Disequilibrium report for YAE1D1 (39605975 - 39649919 bp)

    Structural Variations
          Database of Genomic Variants (DGV) variations for YAE1D1: --
    SABiosciences Cancer Mutation PCR Assays
    Search QIAGEN SeqTarget long-range PCR primers for resequencing YAE1D1
    DNA2.0 Custom Variant and Variant Library Synthesis for YAE1D1

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
      --

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for YAE1D1 gene, integrated from 9 sources (see all 15):
    (articles sorted by number of sources associating them with YAE1D1)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    2. Human chromosome 7: DNA sequence and biology. (PubMed id 12690205)1, 2 Scherer S.W.... Tsui L.-C. (2003)
    3. The DNA sequence of human chromosome 7. (PubMed id 12853948)1, 2 Hillier L.W.... Wilson R.K. (2003)
    4. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1, 3 Strausberg R.L....Marra M.A. (2002)
    5. The function of ORAOV1/LTO1, a gene that is overexpres sed frequently in cancer: essential roles in the function and biogenesis of the ribosome. (PubMed id 23318452)1 Zhai C....Panaretou B. (2013)
    6. Interactions of pathological hallmark proteins: tubul in polymerization promoting protein/p25, beta-amyloid, and alpha-synuclein. (PubMed id 21832049)1 OlA!h J....OvA!di J. (2011)
    7. A directed protein interaction network for investigat ing intracellular signal transduction. (PubMed id 21900206)1 Vinayagam A....Wanker E.E. (2011)
    8. Dynamics of cullin-RING ubiquitin ligase network revea led by systematic quantitative proteomics. (PubMed id 21145461)1 Bennett E.J....Harper J.W. (2010)
    9. Defining the human deubiquitinating enzyme interactio n landscape. (PubMed id 19615732)1 Sowa M.E....Harper J.W. (2009)
    10. A human protein-protein interaction network: a resource for annotating the proteome. (PubMed id 16169070)1 Stelzl U.... Wanker E.E. (2005)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 57002 HGNC: 24857 AceView: C7orf36 Ensembl:ENSG00000241127 euGenes: HUgn57002
    ECgene: YAE1D1 H-InvDB: YAE1D1

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for YAE1D1 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for YAE1D1 gene:
    Search GeneIP for patents involving YAE1D1

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Sirion Biotech, Cell lines from GenScript, and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
    About This Section

     
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    GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 4 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

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    Category
    (GIFtS: 73)
    transforming growth factor, beta 1
    GIFtS Group
    The GeneCards human gene database gene index: 1 3 5 6 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z 


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