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Aliases for YAE1D1 Gene

Aliases for YAE1D1 Gene

  • Yae1 Domain Containing 1 2 3 5
  • C7orf36 3 4
  • Chromosome 7 Open Reading Frame 36 2
  • Yae1 Domain-Containing Protein 1 3
  • GK003 3

External Ids for YAE1D1 Gene

Previous HGNC Symbols for YAE1D1 Gene

  • C7orf36

Previous GeneCards Identifiers for YAE1D1 Gene

  • GC07P039605

Summaries for YAE1D1 Gene

GeneCards Summary for YAE1D1 Gene

YAE1D1 (Yae1 Domain Containing 1) is a Protein Coding gene.

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for YAE1D1 Gene

Genomics for YAE1D1 Gene

Regulatory Elements for YAE1D1 Gene

Enhancers for YAE1D1 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH07F039620 0.4 ENCODE 16.3 +57.3 57346 6.8 HDGF PKNOX1 CREB3L1 WRNIP1 ARID4B SIN3A YBX1 DMAP1 YY1 ZNF143 LINC00265 YAE1D1 LOC100101126 ENSG00000259826 CICP22 RALA GC07M039668
GH07F039540 0.2 ENCODE 12.4 -25.8 -25840 0.2 SOX13 TFAP4 SAP130 CEBPG DMAP1 ZNF644 TEAD3 POLR2A CREM MAFK LOC105375240 YAE1D1 LOC105375237
GH07F039532 0.5 ENCODE 11.7 -31.7 -31686 3.5 ZNF316 GATA2 HLF PBX2 FOXJ2 MAFK LOC105375240 YAE1D1 LOC105375237
GH07F039588 1.3 FANTOM5 Ensembl ENCODE 11.6 +23.4 23425 3.3 PKNOX1 ATF1 ARNT FEZF1 ELK1 GATA2 CBX5 FOS JUNB NCOA1 RALA YAE1D1 LOC105375240 LINC00265 GC07P039582 GC07P039609
GH07F040132 0.5 ENCODE 11.4 +568.0 567959 2.7 PKNOX1 ARNT CREB3L1 WRNIP1 ARID4B SIN3A FEZF1 DMAP1 ZNF2 SLC30A9 MPLKIP LINC00265 CICP22 YAE1D1 LOC100101126 RWDD4P2 ENSG00000259826 ENSG00000228554 GC07P040132
- Elite enhancer/Elite enhancer-gene association Download Table
Download GeneHancer data dump

Enhancers around YAE1D1 on UCSC Golden Path with GeneCards custom track

Promoters for YAE1D1 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000156094 325 2599 HDGF CREB3L1 ARID4B SIN3A DMAP1 ZNF2 YY1 ZNF143 FOS SP3

Genomic Location for YAE1D1 Gene

Chromosome:
7
Start:
39,566,376 bp from pter
End:
39,612,089 bp from pter
Size:
45,714 bases
Orientation:
Plus strand

Genomic View for YAE1D1 Gene

Genes around YAE1D1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
YAE1D1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for YAE1D1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for YAE1D1 Gene

Proteins for YAE1D1 Gene

  • Protein details for YAE1D1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9NRH1-YAED1_HUMAN
    Recommended name:
    Yae1 domain-containing protein 1
    Protein Accession:
    Q9NRH1
    Secondary Accessions:
    • A4D1W4
    • B4DE83
    • Q6IAF7
    • Q8WVZ5

    Protein attributes for YAE1D1 Gene

    Size:
    226 amino acids
    Molecular mass:
    25299 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for YAE1D1 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for YAE1D1 Gene

Post-translational modifications for YAE1D1 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for YAE1D1 Gene

No data available for DME Specific Peptides for YAE1D1 Gene

Domains & Families for YAE1D1 Gene

Protein Domains for YAE1D1 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for YAE1D1 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with YAE1D1: view

No data available for Gene Families and UniProtKB/Swiss-Prot for YAE1D1 Gene

Function for YAE1D1 Gene

Phenotypes for YAE1D1 Gene

MGI mutant phenotypes for YAE1D1:
inferred from 1 alleles
GenomeRNAi human phenotypes for YAE1D1:
genes like me logo Genes that share phenotypes with YAE1D1: view

Animal Models for YAE1D1 Gene

MGI Knock Outs for YAE1D1:

Animal Model Products

miRNA for YAE1D1 Gene

miRTarBase miRNAs that target YAE1D1

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for YAE1D1 Gene

Localization for YAE1D1 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for YAE1D1 Gene COMPARTMENTS Subcellular localization image for YAE1D1 gene
Compartment Confidence
cytosol 3
extracellular 2
nucleus 2
lysosome 1
vacuole 1

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Gene Ontology (GO) - Cellular Components for YAE1D1 Gene

Pathways & Interactions for YAE1D1 Gene

SuperPathways for YAE1D1 Gene

No Data Available

Gene Ontology (GO) - Biological Process for YAE1D1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006413 translational initiation IBA --
GO:0042273 ribosomal large subunit biogenesis IBA --
genes like me logo Genes that share ontologies with YAE1D1: view

No data available for Pathways by source and SIGNOR curated interactions for YAE1D1 Gene

Transcripts for YAE1D1 Gene

Unigene Clusters for YAE1D1 Gene

Yae1 domain containing 1:
Representative Sequences:

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for YAE1D1 Gene

No ASD Table

Relevant External Links for YAE1D1 Gene

GeneLoc Exon Structure for
YAE1D1
ECgene alternative splicing isoforms for
YAE1D1

Expression for YAE1D1 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for YAE1D1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for YAE1D1 Gene

This gene is overexpressed in Bone (64.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for YAE1D1 Gene



Protein tissue co-expression partners for YAE1D1 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of YAE1D1 Gene:

YAE1D1

SOURCE GeneReport for Unigene cluster for YAE1D1 Gene:

Hs.83313
genes like me logo Genes that share expression patterns with YAE1D1: view

Primer Products

No data available for mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for YAE1D1 Gene

Orthologs for YAE1D1 Gene

This gene was present in the common ancestor of chordates.

Orthologs for YAE1D1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia YAE1D1 34
  • 99.56 (n)
C7H7ORF36 35
  • 99 (a)
OneToOne
cow
(Bos Taurus)
Mammalia YAE1D1 34 35
  • 89.38 (n)
dog
(Canis familiaris)
Mammalia YAE1D1 34 35
  • 89.23 (n)
mouse
(Mus musculus)
Mammalia Yae1d1 34 16 35
  • 79.48 (n)
Gm6505 35
  • 69 (a)
OneToMany
oppossum
(Monodelphis domestica)
Mammalia YAE1D1 35
  • 60 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia YAE1D1 35
  • 52 (a)
OneToOne
chicken
(Gallus gallus)
Aves C2H7ORF36 34
  • 60.61 (n)
YAE1D1 35
  • 45 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia YAE1D1 35
  • 46 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia yae1d1 34
  • 53.27 (n)
zebrafish
(Danio rerio)
Actinopterygii fam105ba 34 35
  • 48.64 (n)
Species where no ortholog for YAE1D1 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for YAE1D1 Gene

ENSEMBL:
Gene Tree for YAE1D1 (if available)
TreeFam:
Gene Tree for YAE1D1 (if available)

Paralogs for YAE1D1 Gene

No data available for Paralogs for YAE1D1 Gene

Variants for YAE1D1 Gene

Sequence variations from dbSNP and Humsavar for YAE1D1 Gene

SNP ID Clin Chr 07 pos Sequence Context AA Info Type
rs10085508 -- 39,577,428(+) ccctc(A/C)caggg intron-variant
rs10232859 -- 39,565,605(+) AGCCT(A/G)GAATG intron-variant, upstream-variant-2KB
rs10236547 -- 39,600,078(+) ATGAA(A/C)TGAAG intron-variant
rs10243193 -- 39,583,754(+) gatta(C/T)gtgca intron-variant
rs10245247 -- 39,596,365(+) CCCAA(A/G)TAGCT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for YAE1D1 Gene

Variant ID Type Subtype PubMed ID
dgv6337n100 CNV gain 25217958

Variation tolerance for YAE1D1 Gene

Residual Variation Intolerance Score: 79% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 7.11; 80.55% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for YAE1D1 Gene

Human Gene Mutation Database (HGMD)
YAE1D1
SNPedia medical, phenotypic, and genealogical associations of SNPs for
YAE1D1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for YAE1D1 Gene

Disorders for YAE1D1 Gene

Relevant External Links for YAE1D1

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
YAE1D1

No disorders were found for YAE1D1 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for YAE1D1 Gene

Publications for YAE1D1 Gene

  1. The deca-GX3 proteins Yae1-Lto1 function as adaptors recruiting the ABC protein Rli1 for iron-sulfur cluster insertion. (PMID: 26182403) Paul V.D. … Lill R. (Elife 2015) 2 3 64
  2. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4 64
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4 64
  4. Human chromosome 7: DNA sequence and biology. (PMID: 12690205) Scherer S.W. … Tsui L.-C. (Science 2003) 3 4 64
  5. The DNA sequence of human chromosome 7. (PMID: 12853948) Hillier L.W. … Wilson R.K. (Nature 2003) 3 4 64

Products for YAE1D1 Gene

Sources for YAE1D1 Gene

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