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Aliases for XYLB Gene

Aliases for XYLB Gene

  • Xylulokinase Homolog (H. Influenzae) 2 3
  • EC 2.7.1.17 4 63
  • Xylulokinase (H. Influenzae) Homolog 2
  • Xylulokinase 4

External Ids for XYLB Gene

Previous GeneCards Identifiers for XYLB Gene

  • GC03P037677
  • GC03P038201
  • GC03P038348

Summaries for XYLB Gene

Entrez Gene Summary for XYLB Gene

  • The protein encoded by this gene shares 22% sequence identity with Hemophilus influenzae xylulokinase, and even higher identity to other gene products in C.elegans (45%) and yeast (31-35%), which are thought to belong to a family of enzymes that include fucokinase, gluconokinase, glycerokinase and xylulokinase. These proteins play important roles in energy metabolism. [provided by RefSeq, Aug 2009]

GeneCards Summary for XYLB Gene

XYLB (Xylulokinase Homolog (H. Influenzae)) is a Protein Coding gene. Among its related pathways are Metabolism and Glucuronidation. GO annotations related to this gene include xylulokinase activity.

UniProtKB/Swiss-Prot for XYLB Gene

  • Phosphorylates D-xylulose to produce D-xylulose 5-phosphate, a molecule that may play an important role in the regulation of glucose metabolism and lipogenesis.

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for XYLB Gene

Genomics for XYLB Gene

Regulatory Elements for XYLB Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for XYLB Gene

Start:
38,346,760 bp from pter
End:
38,421,348 bp from pter
Size:
74,589 bases
Orientation:
Plus strand

Genomic View for XYLB Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for XYLB Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for XYLB Gene

Proteins for XYLB Gene

  • Protein details for XYLB Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    O75191-XYLB_HUMAN
    Recommended name:
    Xylulose kinase
    Protein Accession:
    O75191
    Secondary Accessions:
    • B2RAW4
    • B4DDT2
    • B9EH64

    Protein attributes for XYLB Gene

    Size:
    536 amino acids
    Molecular mass:
    58382 Da
    Quaternary structure:
    • Monomer.
    SequenceCaution:
    • Sequence=BAA31527.1; Type=Miscellaneous discrepancy; Note=Probable cloning artifact.; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for XYLB Gene

    Alternative splice isoforms for XYLB Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for XYLB Gene

Proteomics data for XYLB Gene at MOPED

Post-translational modifications for XYLB Gene

  • Ubiquitination at Lys178 and Lys494
  • Modification sites at PhosphoSitePlus

Other Protein References for XYLB Gene

ENSEMBL proteins:
REFSEQ proteins:

Domains for XYLB Gene

Protein Domains for XYLB Gene

Suggested Antigen Peptide Sequences for XYLB Gene

Graphical View of Domain Structure for InterPro Entry

O75191

UniProtKB/Swiss-Prot:

XYLB_HUMAN :
  • O75191
Family:
  • Belongs to the FGGY kinase family.
genes like me logo Genes that share domains with XYLB: view

No data available for Gene Families for XYLB Gene

Function for XYLB Gene

Molecular function for XYLB Gene

GENATLAS Biochemistry: xylulokinase-like,homolog to xylulokinase of H influenzae
UniProtKB/Swiss-Prot BiophysicochemicalProperties: Kinetic parameters: KM=24 uM for D-xylulose {ECO:0000269 PubMed:23179721};
UniProtKB/Swiss-Prot CatalyticActivity: ATP + D-xylulose = ADP + D-xylulose 5-phosphate.
UniProtKB/Swiss-Prot Function: Phosphorylates D-xylulose to produce D-xylulose 5-phosphate, a molecule that may play an important role in the regulation of glucose metabolism and lipogenesis.

Enzyme Numbers (IUBMB) for XYLB Gene

Gene Ontology (GO) - Molecular Function for XYLB Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004856 xylulokinase activity IDA 23179721
GO:0005524 ATP binding IEA --
GO:0016773 phosphotransferase activity, alcohol group as acceptor --
genes like me logo Genes that share ontologies with XYLB: view
genes like me logo Genes that share phenotypes with XYLB: view

Animal Model Products

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for XYLB

In Situ Assay Products

Flow Cytometry Products

No data available for Animal Models , miRNA , Transcription Factor Targeting and HOMER Transcription for XYLB Gene

Localization for XYLB Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for XYLB Gene COMPARTMENTS Subcellular localization image for XYLB gene
Compartment Confidence
cytosol 3
nucleus 2
extracellular 1
mitochondrion 1
peroxisome 1

Gene Ontology (GO) - Cellular Components for XYLB Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0070062 extracellular exosome IDA 23376485
genes like me logo Genes that share ontologies with XYLB: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot for XYLB Gene

Pathways for XYLB Gene

genes like me logo Genes that share pathways with XYLB: view

Pathways by source for XYLB Gene

Interacting Proteins for XYLB Gene

Gene Ontology (GO) - Biological Process for XYLB Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005975 carbohydrate metabolic process TAS 9763671
GO:0005997 xylulose metabolic process IDA 23179721
GO:0005998 xylulose catabolic process TAS 9763671
GO:0006091 generation of precursor metabolites and energy TAS 9763671
GO:0042732 D-xylose metabolic process IEA --
genes like me logo Genes that share ontologies with XYLB: view

Compounds for XYLB Gene

(4) HMDB Compounds for XYLB Gene

Compound Synonyms Cas Number PubMed IDs
Adenosine triphosphate
  • 5'-(tetrahydrogen triphosphate) Adenosine
56-65-5
ADP
  • adenosindiphosphorsaeure
58-64-0
D-Xylulose
  • D-Xylulose
551-84-8
Xylulose 5-phosphate
  • D-xylulose-5-P
4212-65-1
genes like me logo Genes that share compounds with XYLB: view

Transcripts for XYLB Gene

Unigene Clusters for XYLB Gene

Xylulokinase homolog (H. influenzae):
Representative Sequences:

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for XYLB

Primer Products

  • OriGene qSTAR qPCR primer pairs in human,mouse,rat for XYLB

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for XYLB Gene

No ASD Table

Relevant External Links for XYLB Gene

GeneLoc Exon Structure for
XYLB
ECgene alternative splicing isoforms for
XYLB

Expression for XYLB Gene

mRNA expression in normal human tissues for XYLB Gene

mRNA differential expression in normal tissues according to GTEx for XYLB Gene

This gene is overexpressed in Liver (14.5).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for XYLB Gene

SOURCE GeneReport for Unigene cluster for XYLB Gene Hs.659985

genes like me logo Genes that share expressions with XYLB: view

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and mRNA Expression by UniProt/SwissProt for XYLB Gene

Orthologs for XYLB Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for XYLB Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia XYLB 35
  • 99.11 (n)
  • 98.77 (a)
XYLB 36
  • 98 (a)
OneToOne
cow
(Bos Taurus)
Mammalia XYLB 35
  • 88.19 (n)
  • 91.04 (a)
XYLB 36
  • 90 (a)
OneToOne
dog
(Canis familiaris)
Mammalia XYLB 35
  • 89.05 (n)
  • 91.98 (a)
XYLB 36
  • 92 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Xylb 35
  • 85.45 (n)
  • 87.69 (a)
Xylb 16
Xylb 36
  • 85 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia XYLB 36
  • 72 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia -- 36
  • 62 (a)
OneToMany
-- 36
  • 66 (a)
OneToMany
-- 36
  • 74 (a)
OneToMany
-- 36
  • 68 (a)
OneToMany
-- 36
  • 70 (a)
OneToMany
rat
(Rattus norvegicus)
Mammalia Xylb 35
  • 84.83 (n)
  • 87.87 (a)
chicken
(Gallus gallus)
Aves XYLB 35
  • 71.69 (n)
  • 75.29 (a)
XYLB 36
  • 75 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia XYLB 36
  • 71 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia xylb 35
  • 67.56 (n)
  • 65.84 (a)
zebrafish
(Danio rerio)
Actinopterygii xylb 35
  • 64.26 (n)
  • 64.52 (a)
xylb 36
  • 61 (a)
OneToOne
zgc64119 35
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP000220 35
  • 51.29 (n)
  • 47.1 (a)
fruit fly
(Drosophila melanogaster)
Insecta CG3534 35
  • 52.58 (n)
  • 45.7 (a)
CG3534 36
  • 42 (a)
OneToMany
CG3544 36
  • 37 (a)
OneToMany
CG3534 37
  • 44 (a)
CG3544 37
  • 39 (a)
worm
(Caenorhabditis elegans)
Secernentea R08D7.7 35
  • 47.99 (n)
  • 39.69 (a)
R08D7.7 36
  • 39 (a)
OneToOne
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes XKS1 36
  • 30 (a)
OneToOne
XKS1 38
thale cress
(Arabidopsis thaliana)
eudicotyledons XK-2 35
  • 52.13 (n)
  • 50.21 (a)
rice
(Oryza sativa)
Liliopsida Os07g0640200 35
  • 51.29 (n)
  • 48.46 (a)
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.13149 35
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 60 (a)
OneToOne
Species with no ortholog for XYLB:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for XYLB Gene

ENSEMBL:
Gene Tree for XYLB (if available)
TreeFam:
Gene Tree for XYLB (if available)

Paralogs for XYLB Gene

No data available for Paralogs for XYLB Gene

Variants for XYLB Gene

Sequence variations from dbSNP and Humsavar for XYLB Gene

SNP ID Clin Chr 03 pos Sequence Context AA Info Type MAF
rs17118 - 38,362,981(+) TTCGA(A/C)TTCTC missense, reference, intron-variant, nc-transcript-variant
rs149290 -- 38,366,875(-) AACCA(A/G)CCTCT splice-donor-variant
rs149740 -- 38,389,158(-) ggcag(A/C)atgct intron-variant
rs149741 -- 38,384,625(-) CATGA(A/C)TCTTT intron-variant
rs151611 - 38,365,646(-) CTGGA(G/T)TCCAT missense, reference, nc-transcript-variant

Structural Variations from Database of Genomic Variants (DGV) for XYLB Gene

Variant ID Type Subtype PubMed ID
nsv237015 CNV Loss 16902084
esv2584185 CNV Insertion 19546169
esv271513 CNV Insertion 20981092
esv273653 CNV Insertion 20981092
nsv238024 CNV Loss 16902084

Relevant External Links for XYLB Gene

HapMap Linkage Disequilibrium report
XYLB

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for XYLB Gene

Disorders for XYLB Gene

(1) University of Copenhagen DISEASES for XYLB Gene

Relevant External Links for XYLB

Genetic Association Database (GAD)
XYLB
Human Genome Epidemiology (HuGE) Navigator
XYLB
genes like me logo Genes that share disorders with XYLB: view

No data available for UniProtKB/Swiss-Prot for XYLB Gene

Publications for XYLB Gene

  1. Genomic structure of a novel human gene (XYLB) on chromosome 3p22-->p21.3 encoding a xylulokinase-like protein. (PMID: 9763671) Tamari M. … Nakamura Y. (Cytogenet. Cell Genet. 1998) 2 3 4 23
  2. Structure and function of human xylulokinase, an enzyme with important roles in carbohydrate metabolism. (PMID: 23179721) Bunker R.D. … Baker E.N. (J. Biol. Chem. 2013) 3 4
  3. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4
  4. Genome-wide association study of electrocardiographic conduction measures in an isolated founder population: Kosrae. (PMID: 19389651) Smith J.G. … Newton-Cheh C. (Heart Rhythm 2009) 3 48
  5. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose J.E. … Uhl G.R. (Mol. Med. 2010) 3 48

Products for XYLB Gene

  • Addgene plasmids for XYLB

Sources for XYLB Gene

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