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Aliases for XYLB Gene

Aliases for XYLB Gene

  • Xylulokinase Homolog (H. Influenzae) 2 3 5
  • EC 4 63
  • Xylulokinase (H. Influenzae) Homolog 2
  • Xylulokinase 4

External Ids for XYLB Gene

Previous GeneCards Identifiers for XYLB Gene

  • GC03P037677
  • GC03P038201
  • GC03P038348

Summaries for XYLB Gene

Entrez Gene Summary for XYLB Gene

  • The protein encoded by this gene shares 22% sequence identity with Hemophilus influenzae xylulokinase, and even higher identity to other gene products in C.elegans (45%) and yeast (31-35%), which are thought to belong to a family of enzymes that include fucokinase, gluconokinase, glycerokinase and xylulokinase. These proteins play important roles in energy metabolism. [provided by RefSeq, Aug 2009]

GeneCards Summary for XYLB Gene

XYLB (Xylulokinase Homolog (H. Influenzae)) is a Protein Coding gene. Among its related pathways are Glycosaminoglycan metabolism and Metabolism. GO annotations related to this gene include phosphotransferase activity, alcohol group as acceptor and xylulokinase activity.

UniProtKB/Swiss-Prot for XYLB Gene

  • Phosphorylates D-xylulose to produce D-xylulose 5-phosphate, a molecule that may play an important role in the regulation of glucose metabolism and lipogenesis.

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for XYLB Gene

Genomics for XYLB Gene

Regulatory Elements for XYLB Gene

Enhancers for XYLB Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around XYLB on UCSC Golden Path with GeneCards custom track

Promoters for XYLB Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around XYLB on UCSC Golden Path with GeneCards custom track

Genomic Location for XYLB Gene

38,346,760 bp from pter
38,453,041 bp from pter
106,282 bases
Plus strand

Genomic View for XYLB Gene

Genes around XYLB on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
XYLB Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for XYLB Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for XYLB Gene

Proteins for XYLB Gene

  • Protein details for XYLB Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Xylulose kinase
    Protein Accession:
    Secondary Accessions:
    • B2RAW4
    • B4DDT2
    • B9EH64

    Protein attributes for XYLB Gene

    536 amino acids
    Molecular mass:
    58382 Da
    Quaternary structure:
    • Monomer.
    • Sequence=BAA31527.1; Type=Miscellaneous discrepancy; Note=Probable cloning artifact.; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for XYLB Gene

    Alternative splice isoforms for XYLB Gene


neXtProt entry for XYLB Gene

Proteomics data for XYLB Gene at MOPED

Post-translational modifications for XYLB Gene

  • Ubiquitination at Lys 178 and Lys 494
  • Modification sites at PhosphoSitePlus

Other Protein References for XYLB Gene

ENSEMBL proteins:
REFSEQ proteins:

Domains & Families for XYLB Gene

Protein Domains for XYLB Gene

Suggested Antigen Peptide Sequences for XYLB Gene

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the FGGY kinase family.
  • Belongs to the FGGY kinase family.
genes like me logo Genes that share domains with XYLB: view

No data available for Gene Families for XYLB Gene

Function for XYLB Gene

Molecular function for XYLB Gene

GENATLAS Biochemistry:
xylulokinase-like,homolog to xylulokinase of H influenzae
UniProtKB/Swiss-Prot BiophysicochemicalProperties:
Kinetic parameters: KM=24 uM for D-xylulose {ECO:0000269 PubMed:23179721};
UniProtKB/Swiss-Prot CatalyticActivity:
ATP + D-xylulose = ADP + D-xylulose 5-phosphate.
UniProtKB/Swiss-Prot Function:
Phosphorylates D-xylulose to produce D-xylulose 5-phosphate, a molecule that may play an important role in the regulation of glucose metabolism and lipogenesis.

Enzyme Numbers (IUBMB) for XYLB Gene

genes like me logo Genes that share phenotypes with XYLB: view

Animal Models for XYLB Gene

MGI Knock Outs for XYLB:
  • Xylb tm1a(EUCOMM)Hmgu

Animal Model Products

  • Taconic Biosciences Mouse Models for XYLB

miRNA for XYLB Gene

No data available for Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for XYLB Gene

Localization for XYLB Gene

Subcellular locations from

Jensen Localization Image for XYLB Gene COMPARTMENTS Subcellular localization image for XYLB gene
Compartment Confidence
cytosol 5
extracellular 5
nucleus 2
mitochondrion 1
peroxisome 1

Gene Ontology (GO) - Cellular Components for XYLB Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm IBA --
genes like me logo Genes that share ontologies with XYLB: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot for XYLB Gene

Pathways & Interactions for XYLB Gene

genes like me logo Genes that share pathways with XYLB: view

Pathways by source for XYLB Gene

Interacting Proteins for XYLB Gene

Gene Ontology (GO) - Biological Process for XYLB Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005975 carbohydrate metabolic process IEA,TAS 9763671
GO:0019640 glucuronate catabolic process to xylulose 5-phosphate TAS --
GO:0042732 D-xylose metabolic process IEA --
GO:0044281 small molecule metabolic process TAS --
genes like me logo Genes that share ontologies with XYLB: view

No data available for SIGNOR curated interactions for XYLB Gene

Drugs & Compounds for XYLB Gene

(2) Drugs for XYLB Gene - From: HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Adenosine triphosphate Approved Nutra 0
D-Xylulose Experimental Pharma 0

(2) Additional Compounds for XYLB Gene - From: HMDB

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
  • Adenosindiphosphorsaeure
  • Adenosine 5'-pyrophosphate
  • Adenosine diphosphate
  • Adenosine pyrophosphate
  • Adenosine-5'-diphosphate
Full agonist, Agonist 58-64-0
Xylulose 5-phosphate
  • D-Xylulose 5-phosphate
  • D-Xylulose 5-PO4
  • D-Xylulose-5-P
  • D-Xylulose-5-phosphate
  • Xu-5-P
genes like me logo Genes that share compounds with XYLB: view

Transcripts for XYLB Gene

Unigene Clusters for XYLB Gene

Xylulokinase homolog (H. influenzae):
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for XYLB Gene

No ASD Table

Relevant External Links for XYLB Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for XYLB Gene

mRNA expression in normal human tissues for XYLB Gene

mRNA differential expression in normal tissues according to GTEx for XYLB Gene

This gene is overexpressed in Liver (x14.5).

Protein differential expression in normal tissues from HIPED for XYLB Gene

This gene is overexpressed in Liver (20.7), Gallbladder (20.2), and Skin (10.1).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for XYLB Gene

SOURCE GeneReport for Unigene cluster for XYLB Gene Hs.659985

genes like me logo Genes that share expression patterns with XYLB: view

Protein tissue co-expression partners for XYLB Gene

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and mRNA Expression by UniProt/SwissProt for XYLB Gene

Orthologs for XYLB Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for XYLB Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia XYLB 35
  • 88.19 (n)
  • 91.04 (a)
  • 90 (a)
(Canis familiaris)
Mammalia XYLB 35
  • 89.05 (n)
  • 91.98 (a)
  • 92 (a)
(Mus musculus)
Mammalia Xylb 35
  • 85.45 (n)
  • 87.69 (a)
Xylb 16
Xylb 36
  • 85 (a)
(Pan troglodytes)
Mammalia XYLB 35
  • 99.11 (n)
  • 98.77 (a)
  • 98 (a)
(Rattus norvegicus)
Mammalia Xylb 35
  • 84.83 (n)
  • 87.87 (a)
(Monodelphis domestica)
Mammalia XYLB 36
  • 72 (a)
(Ornithorhynchus anatinus)
Mammalia -- 36
  • 62 (a)
-- 36
  • 66 (a)
-- 36
  • 74 (a)
-- 36
  • 68 (a)
-- 36
  • 70 (a)
(Gallus gallus)
Aves XYLB 35
  • 71.69 (n)
  • 75.29 (a)
  • 75 (a)
(Anolis carolinensis)
Reptilia XYLB 36
  • 71 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia xylb 35
  • 67.56 (n)
  • 65.84 (a)
(Danio rerio)
Actinopterygii xylb 35
  • 64.26 (n)
  • 64.52 (a)
zgc64119 35
xylb 36
  • 61 (a)
fruit fly
(Drosophila melanogaster)
Insecta CG3534 37
  • 44 (a)
CG3544 37
  • 39 (a)
CG3534 35
  • 52.58 (n)
  • 45.7 (a)
CG3534 36
  • 42 (a)
CG3544 36
  • 37 (a)
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP000220 35
  • 51.29 (n)
  • 47.1 (a)
(Caenorhabditis elegans)
Secernentea R08D7.7 35
  • 47.99 (n)
  • 39.69 (a)
R08D7.7 36
  • 39 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes XKS1 36
  • 30 (a)
XKS1 38
thale cress
(Arabidopsis thaliana)
eudicotyledons XK-2 35
  • 52.13 (n)
  • 50.21 (a)
(Oryza sativa)
Liliopsida Os07g0640200 35
  • 51.29 (n)
  • 48.46 (a)
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.13149 35
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 60 (a)
Species with no ortholog for XYLB:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for XYLB Gene

Gene Tree for XYLB (if available)
Gene Tree for XYLB (if available)

Paralogs for XYLB Gene

No data available for Paralogs for XYLB Gene

Variants for XYLB Gene

Sequence variations from dbSNP and Humsavar for XYLB Gene

SNP ID Clin Chr 03 pos Sequence Context AA Info Type
rs17118 - 38,362,981(+) TTCGA(A/C)TTCTC intron-variant, reference, missense
rs2234610 - 38,365,626(+) TCAGC(A/G)ACTGC reference, missense
rs151611 - 38,365,646(-) CTGGA(G/T)TCCAT reference, missense
rs196380 - 38,372,673(-) GACGT(A/T)GTAGG reference, missense
rs2234622 - 38,376,154(+) TCCGC(A/G)ACGAG reference, missense

Structural Variations from Database of Genomic Variants (DGV) for XYLB Gene

Variant ID Type Subtype PubMed ID
nsv237015 CNV Loss 16902084
esv2584185 CNV Insertion 19546169
esv271513 CNV Insertion 20981092
esv273653 CNV Insertion 20981092
nsv238024 CNV Loss 16902084

Variation tolerance for XYLB Gene

Residual Variation Intolerance Score: 86.2% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 9.80; 89.52% of all genes are more intolerant (likely to be disease-causing)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Relevant External Links for XYLB Gene

Disorders for XYLB Gene

Relevant External Links for XYLB

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator
Atlas of Genetics and Cytogenetics in Oncology and Haematology:

No disorders were found for XYLB Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for XYLB Gene

Publications for XYLB Gene

  1. Genomic structure of a novel human gene (XYLB) on chromosome 3p22-->p21.3 encoding a xylulokinase-like protein. (PMID: 9763671) Tamari M. … Nakamura Y. (Cytogenet. Cell Genet. 1998) 2 3 4 23 67
  2. Pooled genetic analysis reveals an association of SNPs of only a few genes with risk predisposition to ischemic stroke in a Chinese population. (PMID: 25855559) Zhang Z. … Xie X. (IUBMB Life 2015) 3
  3. Panorama of ancient metazoan macromolecular complexes. (PMID: 26344197) Wan C. … Emili A. (Nature 2015) 3
  4. Genetic determinants of P wave duration and PR segment. (PMID: 24850809) Verweij N. … van der Harst P. (Circ Cardiovasc Genet 2014) 3
  5. Structure and function of human xylulokinase, an enzyme with important roles in carbohydrate metabolism. (PMID: 23179721) Bunker R.D. … Baker E.N. (J. Biol. Chem. 2013) 3

Products for XYLB Gene

Sources for XYLB Gene