XXYLT1 Gene
protein-coding GIFtS: 41
GCID: GC03M194790
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xyloside xylosyltransferase 1(Previous name: chromosome 3 open reading frame 21 ) (Previous symbol: C3orf21)
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Aliases for XXYLT1 gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb) About This Section
|
| Aliases |
|---|
| Xyloside Xylosyltransferase 11 2 | | C3orf211 2 3 | | UDP-Xylose:Alpha-Xyloside Alpha-1,3-Xylosyltransferase2 3 | | FLJ351551 | | Chromosome 3 Open Reading Frame 211 | | EC 2.4.2.N31 |
Export aliases for XXYLT1 gene to outside databases |
Summaries for XXYLT1 gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
| UniProtKB/Swiss-Prot: XXLT1_HUMAN, Q8NBI6Function: Alpha-1,3-xylosyltransferase, which elongates the O-linked xylose-glucose disaccharide attached to EGF-likerepeats in the extracellular domain of Notch proteins by catalyzing the addition of the second xylose
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Genomic Views for XXYLT1 gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics) About This Section
| RefSeq DNA sequence:- NC_000003.11 NC_018914.1 NT_029928.13
Regulatory elements: Search SABiosciences Regulatory transcription factor binding sites for XXYLT1 Other transcription factors
Search SABiosciences Chromatin IP Primers for XXYLT1
Epigenetics:
|  | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat XXYLT1 |
Genomic Location: Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 3q29 Ensembl cytogenetic band: 3q29 HGNC cytogenetic band: 3q29XXYLT1 Gene in genomic location: bands according to Ensembl, locations according to
(and/or Entrez Gene and/or Ensembl if different)

GeneLoc information about chromosome 3 GeneLoc Exon Structure GeneLoc location for GC03M194790: view genomic region
(about GC identifiers)
Start:
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194,789,008 bp from pter |
End:
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194,991,896 bp from pter |
Size:
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202,889 bases |
Orientation:
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minus strand |
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Proteins for XXYLT1 gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
| UniProtKB/Swiss-Prot: XXLT1_HUMAN, Q8NBI6 (See
protein sequence)Recommended Name: Xyloside xylosyltransferase 1 Size: 393 amino acids; 43807 Da
Subunit: Monomer. Homodimer. Dimer formation may be essential for the retention in endoplasmic reticulum
Subcellular location: Endoplasmic reticulum membrane; Single-pass type II membrane protein
Caution: It is uncertain whether Met-1 or Met-14 is the initiator
Sequence caution: Sequence=AAH19036.1; Type=Erroneous initiation; Note=Translation N-terminally extended;
Secondary accessions: D3DNW5 Q8NAL3 Q8WV03 Q96ME0Alternative splicing: 3 isoforms: Q8NBI6-1 Q8NBI6-2 Q8NBI6-3 (No experimental confirmation available)Explore the universe of human proteins at neXtProt for XXYLT1: NX_Q8NBI6
Post-translational modifications:
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_Q8NBI6 XXYLT1 Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins: NP_689744.3 ENSEMBL proteins: ENSP00000309640 ENSP00000409865 ENSP00000399422 ENSP00000349179 ENSP00000393989 ENSP00000405583 ENSP00000347967 Human Recombinant Protein Products:
Gene Ontology (GO): 2 cellular component terms (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0005789 | endoplasmic reticulum membrane |
IEA | -- | | GO:0016021 | integral to membrane |
IEA | -- |
XXYLT1 for ontologies About GeneDecksing
XXYLT1 Antibody Products: Assay Products for XXYLT1: |
Protein
Domains / Families for XXYLT1 gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
XXYLT1 for domains About GeneDecksing
1 InterPro domain/family:Graphical View of Domain Structure for InterPro Entry Q8NBI6ProtoNet protein and cluster: Q8NBI6 1 Blocks protein family: IPB002495 Glycosyl transferase
UniProtKB/Swiss-Prot: XXLT1_HUMAN, Q8NBI6Similarity: Belongs to the glycosyltransferase 8 family |
Function for XXYLT1 gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
| Function Summary: UniProtKB/Swiss-Prot: XXLT1_HUMAN, Q8NBI6Function: Alpha-1,3-xylosyltransferase, which elongates the O-linked xylose-glucose disaccharide attached to EGF-likerepeats in the extracellular domain of Notch proteins by catalyzing the addition of the second xyloseCatalytic activity: UDP-D-xylose + alpha-D-xylose-(1->3)-beta-D-glucosyl-R = UDP +alpha-D-xylose-(1->3)-alpha-D-xylose-(1->3)-beta-D-glucosyl-REnzyme Number (IUBMB): EC 2.4.2.n31
Clone Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for XXYLT1 (see all 2) OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for XXYLT1 (see all 2) OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling 
| |  | GenScript Custom all cDNA clones Services for XXYLT1 | |  | Browse Sino Biological Human cDNA Clones | |  | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for XXYLT1 | |  | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat XXYLT1  |
In Situ Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for XXYLT1 |
Gene Ontology (GO): 1 molecular function term (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0016763 | transferase activity, transferring pentosyl groups |
IEA | -- |
XXYLT1 for ontologies About GeneDecksing
|
Pathways & Interactions for XXYLT1 gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Interactions:
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for XXYLT1
STRING Interaction
Network Preview (showing 4 interactants - click image to see more details)
 4 Interacting proteins for XXYLT1 (ENSP000003096404) via UniProtKB, MINT, STRING, and/or I2DAbout this table
|
Drugs & Compounds for XXYLT1 gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
Browse Tocris compounds for XXYLT1 Search CenterWatch for drugs/clinical trials and news about XXYLT1 / XXLT1 
|
Transcripts for XXYLT1 gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank, RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
) About This Section
| REFSEQ mRNAs for XXYLT1 gene: NM_152531.4 Unigene Clusters for XXYLT1: Xyloside xylosyltransferase 1 Hs.478741 [show with all ESTs], Hs.743284 [show with all ESTs]Unigene Representative Sequences: NM_152531, AK02418113 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000310380(uc003fuk.3 uc003fum.4) ENST00000437101(uc003ful.3) ENST00000460582 ENST00000473200 ENST00000429994(uc011bsw.1) ENST00000356740 ENST00000418940 ENST00000491138 ENST00000496644 ENST00000476897 ENST00000494175 ENST00000455281 ENST00000355729
Clone Products: |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for XXYLT1 (see all 2) OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for XXYLT1 (see all 2) OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling 
| |  | GenScript Custom all cDNA clones Services for XXYLT1 | |  | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for XXYLT1 | |  | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat XXYLT1  |
Additional cDNA sequence: AK024181.1 AK057046.1 9 DOTS entries: DT.97841771 DT.91741423 DT.40229786 DT.95135847 DT.91722176 DT.91741418 DT.95375033 DT.97773649 DT.99946695 24/116 AceView cDNA sequences (see all 116): BU556747 AI459991 BE220593 AX747562 BX385479 AK092474 AI459077 BI915160 AK075551 AI954532 BQ669651 AA340323 CR591622 BQ894206 CR626411 AA338587 BU184281 AI298918 BE515127 AI863661 BG753678 AU122209 CR614018 BE794557 GeneLoc Exon Structure
5/7 Alternative Splicing Database (ASD) splice patterns (SP) for XXYLT1 (see all 7) About this scheme
| ExUns: | 1 | ^ | 2 | ^ | 3 | ^ | 4 | ^ | 5 | ^ | 6 | ^ | 7 | ^ | 8 | ^ | 9 | ^ | 10 | ^ | 11 | ^ | 12 | ^ | 13a | · | 13b | · | 13c | · | 13d | · | 13e | |
| SP1: | |   | |   | |   | |   | |   | |   | |   | - |   | - |   | - |   | - |   | - |   | |   | |   | |   | |   | |   | |
| SP2: | |   | |   | - |   | - |   | - |   | - |   | |   | - |   | - |   | - |   | - |   | - |   | |   | |   | |   | |   | |   | |
| SP3: | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |
| SP4: | |   | |   | |   | |   | |   | |   | |   | |   | - |   | - |   | - |   | - |   | |   | |   | |   | |   | |   | |
| SP5: | |   | |   | |   | |   | |   | |   | |   | |   | |   | - |   | - |   | - |   | |   | |   | |   | |   | |   |
ECgene alternative splicing isoforms for XXYLT1
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Expression for XXYLT1 gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| XXYLT1 expression in normal human tissues (normalized intensities) See probesets specificity/sensitivity at GeneAnnot About this imageBioGPS CGAP TAG: AGTGAGGATA
About this image See XXYLT1 Protein Expression from SPIRE MOPED and PaxDB Genevestigator expression for XXYLT1
SOURCE GeneReport for Unigene clusters: Hs.478741 Hs.743284 SABiosciences Custom PCR Arrays for XXYLT1
Primer Products: |  | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for XXYLT1 Browse OriGene validated miRNA SYBR primer pairs
| |  | Search SABiosciences RT2 qPCR
Primer Assays in human, mouse, rat XXYLT1 | |  | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat XXYLT1 | |  | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat XXYLT1 | In Situ Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for XXYLT1 |
Orthologs for XXYLT1 gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of animals.
Orthologs for XXYLT1 gene from 6/17 species (see all 17) About this table
ENSEMBL Gene Tree for XXYLT1 (if available) TreeFam Gene Tree for XXYLT1 (if available)  |
Paralogs for XXYLT1 gene(Paralogs according to
1HomoloGene, 2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68) About This Section
| -- |
Genomic Variants for XXYLT1 gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical significance | Chr 3 pos | Sequence | # | AA Chg | Type | More | # | Allele freq | Pop | Total sample | More |
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HapMap Linkage Disequilibrium report for XXYLT1 (194789008 - 194991896 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions) Database of Genomic Variants (DGV) variations for XXYLT1: --  | SABiosciences Cancer Mutation PCR Assays |
|  | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing XXYLT1 |
|
Disorders
/ Diseases for XXYLT1 gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
XXYLT1 for disorders About GeneDecksing
OMIM gene information: 614552
OMIM disorders: --
1 disease for XXYLT1: About MalaCardslung cancer Export disorders for XXYLT1 gene to outside databases
|
Publications for XXYLT1 gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for XXYLT1 gene integrated from 9 sources: (articles sorted by number of sources associating them with XXYLT1) | |  | Utopia: connect your pdf to the dynamic world of online information |
- Molecular cloning of a xylosyltransferase that transfers the second xylose to O-glucosylated epidermal growth factor repeats of Notch. (PubMed id 22117070)1, 2, 3 Sethi M.K.... Bakker H. (2011)
- Signal sequence and keyword trap in silico for selection of full- length human cDNAs encoding secretion or membrane proteins from oligo- capped cDNA libraries. (PubMed id 16303743)1, 2 Otsuki T....Isogai T. (2005)
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
- Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
- A proteome-wide, quantitative survey of in vivo ubiqui tylation sites reveals widespread regulatory roles. (PubMed id 21890473)1 Wagner S.A....Choudhary C. (2011)
- A genome-wide association study reveals susceptibilit y variants for non-small cell lung cancer in the Korean population. (PubMed id 20876614)1 Yoon K.A....Lee J.S. (2010)
- Dynamics of cullin-RING ubiquitin ligase network revea led by systematic quantitative proteomics. (PubMed id 21145461)1 Bennett E.J....Harper J.W. (2010)
- Ubiquitin-mediated proteolysis of HuR by heat shock. (PubMed id 19322201)1 Abdelmohsen K....Gorospe M. (2009)
- Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. (PubMed id 16344560)1 Kimura K.... Sugano S. (2006)
- Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (2002)
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External Searches for XXYLT1 gene
(in PubMed,
OMIM, and NCBI Bookshelf) About This Section
|
|
Genome Databases showing XXYLT1 gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing XXYLT1 gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing XXYLT1 gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL, Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot) About This Section
|
| Name | Description |
| PharmGKB entry for XXYLT1 | Pharmacogenomics, SNPs, Pathways |
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| | |
About This Section
| Patent Information for XXYLT1 gene: Search GeneIP for patents involving XXYLT1
GeneCards and IP: Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products for XXYLT1 gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences), In Situ Hybridization Assays from Advanced Cell Diagnostics About This Section
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 | |
 | |
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| | QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat XXYLT1 | | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing XXYLT1 | | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat XXYLT1 | | QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat XXYLT1 | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat XXYLT1 | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat XXYLT1 |
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| | | Search Tocris compounds for XXYLT1 |
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 | | XXYLT1 Proteins, Antibodies, CLIAs, and ELISAs |
| | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for XXYLT1 |
|  |  |  | | | ThermoFisher Antibodies for XXYLT1 |
| | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat XXYLT1 |
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