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Aliases for XXYLT1 Gene

Aliases for XXYLT1 Gene

  • Xyloside Xylosyltransferase 1 2 3
  • C3orf21 3 4 6
  • UDP-Xylose:Alpha-Xyloside Alpha-1,3-Xylosyltransferase 3 4
  • Chromosome 3 Open Reading Frame 21 2
  • EC 2.4.2.n3 4

External Ids for XXYLT1 Gene

Previous HGNC Symbols for XXYLT1 Gene

  • C3orf21

Previous GeneCards Identifiers for XXYLT1 Gene

  • GC03M194790

Summaries for XXYLT1 Gene

GeneCards Summary for XXYLT1 Gene

XXYLT1 (Xyloside Xylosyltransferase 1) is a Protein Coding gene. GO annotations related to this gene include transferase activity, transferring pentosyl groups. An important paralog of this gene is LARGE.

UniProtKB/Swiss-Prot for XXYLT1 Gene

  • Alpha-1,3-xylosyltransferase, which elongates the O-linked xylose-glucose disaccharide attached to EGF-like repeats in the extracellular domain of Notch proteins by catalyzing the addition of the second xylose.

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for XXYLT1 Gene

Genomics for XXYLT1 Gene

Genomic Location for XXYLT1 Gene

Start:
195,068,279 bp from pter
End:
195,271,167 bp from pter
Size:
202,889 bases
Orientation:
Minus strand

Genomic View for XXYLT1 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for XXYLT1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for XXYLT1 Gene

No data available for Regulatory Elements for XXYLT1 Gene

Proteins for XXYLT1 Gene

  • Protein details for XXYLT1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8NBI6-XXLT1_HUMAN
    Recommended name:
    Xyloside xylosyltransferase 1
    Protein Accession:
    Q8NBI6
    Secondary Accessions:
    • D3DNW5
    • Q8NAL3
    • Q8WV03
    • Q96ME0

    Protein attributes for XXYLT1 Gene

    Size:
    393 amino acids
    Molecular mass:
    43807 Da
    Quaternary structure:
    • Monomer. Homodimer. Dimer formation may be essential for the retention in endoplasmic reticulum.
    SequenceCaution:
    • Sequence=AAH19036.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305};

    Alternative splice isoforms for XXYLT1 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for XXYLT1 Gene

Proteomics data for XXYLT1 Gene at MOPED

Post-translational modifications for XXYLT1 Gene

  • Ubiquitination at Lys321
  • Glycosylation at Ser67 and Ser77
  • Modification sites at PhosphoSitePlus

Other Protein References for XXYLT1 Gene

No data available for DME Specific Peptides for XXYLT1 Gene

Domains for XXYLT1 Gene

Gene Families for XXYLT1 Gene

HGNC:
  • GLT8 :Glycosyltransferase family 8 domain containing

Protein Domains for XXYLT1 Gene

Graphical View of Domain Structure for InterPro Entry

Q8NBI6

UniProtKB/Swiss-Prot:

XXLT1_HUMAN :
  • Q8NBI6
Family:
  • Belongs to the glycosyltransferase 8 family.
genes like me logo Genes that share domains with XXYLT1: view

No data available for Suggested Antigen Peptide Sequences for XXYLT1 Gene

Function for XXYLT1 Gene

Molecular function for XXYLT1 Gene

UniProtKB/Swiss-Prot CatalyticActivity: UDP-alpha-D-xylose + alpha-D-xylose-(1->3)-beta-D-glucosyl-R = UDP + alpha-D-xylose-(1->3)-alpha-D-xylose-(1->3)-beta-D-glucosyl-R.
UniProtKB/Swiss-Prot Function: Alpha-1,3-xylosyltransferase, which elongates the O-linked xylose-glucose disaccharide attached to EGF-like repeats in the extracellular domain of Notch proteins by catalyzing the addition of the second xylose.

Enzyme Numbers (IUBMB) for XXYLT1 Gene

Gene Ontology (GO) - Molecular Function for XXYLT1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016757 transferase activity, transferring glycosyl groups --
GO:0016763 transferase activity, transferring pentosyl groups IEA --
genes like me logo Genes that share ontologies with XXYLT1: view

No data available for Phenotypes , Animal Models , miRNA , Transcription Factor Targeting and HOMER Transcription for XXYLT1 Gene

Localization for XXYLT1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for XXYLT1 Gene

Endoplasmic reticulum membrane; Single-pass type II membrane protein.

Gene Ontology (GO) - Cellular Components for XXYLT1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005783 endoplasmic reticulum --
GO:0005789 endoplasmic reticulum membrane IEA --
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with XXYLT1: view

No data available for Subcellular locations from COMPARTMENTS for XXYLT1 Gene

Pathways for XXYLT1 Gene

SuperPathways for XXYLT1 Gene

No Data Available

Interacting Proteins for XXYLT1 Gene

STRING Interaction Network Preview (showing 2 interactants - click image to see details)
http://string-db.org/version_10/api/image/networkList?limit=0&targetmode=proteins&caller_identity=gene_cards&network_flavor=evidence&identifiers=9606.ENSP00000309640%0d%0a9606.ENSP00000344818%0d%0a9606.ENSP00000385269%0d%0a
Selected Interacting proteins: ENSP00000309640 for XXYLT1 Gene via STRING

Gene Ontology (GO) - Biological Process for XXYLT1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0008152 metabolic process IEA --
genes like me logo Genes that share ontologies with XXYLT1: view

No data available for Pathways by source for XXYLT1 Gene

Transcripts for XXYLT1 Gene

Unigene Clusters for XXYLT1 Gene

Xyloside xylosyltransferase 1:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for XXYLT1 Gene

ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12 ^ 13a · 13b · 13c · 13d · 13e
SP1: - - - - -
SP2: - - - - - - - - -
SP3:
SP4: - - - -
SP5: - - -
SP6: - -
SP7: - - -

Relevant External Links for XXYLT1 Gene

GeneLoc Exon Structure for
XXYLT1
ECgene alternative splicing isoforms for
XXYLT1

Expression for XXYLT1 Gene

mRNA expression in normal human tissues for XXYLT1 Gene

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for XXYLT1 Gene

SOURCE GeneReport for Unigene cluster for XXYLT1 Gene Hs.478741

genes like me logo Genes that share expressions with XXYLT1: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for XXYLT1 Gene

Orthologs for XXYLT1 Gene

This gene was present in the common ancestor of animals.

Orthologs for XXYLT1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia XXYLT1 35
  • 99.32 (n)
  • 99.24 (a)
XXYLT1 36
  • 99 (a)
OneToOne
cow
(Bos Taurus)
Mammalia XXYLT1 35
  • 92.09 (n)
  • 95.66 (a)
XXYLT1 36
  • 84 (a)
OneToOne
dog
(Canis familiaris)
Mammalia XXYLT1 36
  • 93 (a)
OneToOne
mouse
(Mus musculus)
Mammalia AI480653 16
Xxylt1 35
  • 89.46 (n)
  • 91.84 (a)
Xxylt1 36
  • 93 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia XXYLT1 36
  • 77 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Xxylt1 35
  • 88.86 (n)
  • 92.09 (a)
chicken
(Gallus gallus)
Aves XXYLT1 35
  • 70.55 (n)
  • 71.04 (a)
lizard
(Anolis carolinensis)
Reptilia XXYLT1 36
  • 65 (a)
OneToOne
African clawed frog
(Xenopus laevis)
Amphibia Xl.19504 35
tropical clawed frog
(Silurana tropicalis)
Amphibia c3orf21 35
  • 68.54 (n)
  • 69.71 (a)
zebrafish
(Danio rerio)
Actinopterygii LOC100334669 35
  • 64.53 (n)
  • 62.4 (a)
XXYLT1 (1 of 2) 36
  • 60 (a)
OneToMany
XXYLT1 (2 of 2) 36
  • 60 (a)
OneToMany
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP007604 35
  • 55.02 (n)
  • 42.31 (a)
fruit fly
(Drosophila melanogaster)
Insecta CG11388 35
  • 54.43 (n)
  • 44.41 (a)
CG11388 36
  • 32 (a)
OneToOne
sea squirt
(Ciona savignyi)
Ascidiacea CSA.8510 36
  • 30 (a)
OneToOne
Species with no ortholog for XXYLT1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for XXYLT1 Gene

ENSEMBL:
Gene Tree for XXYLT1 (if available)
TreeFam:
Gene Tree for XXYLT1 (if available)

Paralogs for XXYLT1 Gene

Paralogs for XXYLT1 Gene

genes like me logo Genes that share paralogs with XXYLT1: view

Variants for XXYLT1 Gene

Sequence variations from dbSNP and Humsavar for XXYLT1 Gene

SNP ID Clin Chr 03 pos Sequence Context AA Info Type MAF
rs721007 -- 195,182,929(+) TTCCT(A/C)AATCT intron-variant
rs729820 -- 195,200,602(+) CCTAC(A/G)ATCGG intron-variant
rs736919 -- 195,198,290(+) AAGGA(C/G)GAAGT intron-variant
rs736920 -- 195,198,340(+) TCCCA(C/T)TCCCC intron-variant
rs750469 -- 195,157,511(-) TCTTA(A/G)GTGCC intron-variant

Relevant External Links for XXYLT1 Gene

HapMap Linkage Disequilibrium report
XXYLT1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Structural Variations from Database of Genomic Variants (DGV) for XXYLT1 Gene

Disorders for XXYLT1 Gene

No disorders were found for XXYLT1 Gene.

No data available for UniProtKB/Swiss-Prot for XXYLT1 Gene

Publications for XXYLT1 Gene

  1. Molecular cloning of a xylosyltransferase that transfers the second xylose to O-glucosylated epidermal growth factor repeats of Notch. (PMID: 22117070) Sethi M.K. … Bakker H. (J. Biol. Chem. 2012) 2 3 4
  2. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4
  4. Signal sequence and keyword trap in silico for selection of full- length human cDNAs encoding secretion or membrane proteins from oligo- capped cDNA libraries. (PMID: 16303743) Otsuki T. … Isogai T. (DNA Res. 2005) 3 4
  5. Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. (PMID: 16344560) Kimura K. … Sugano S. (Genome Res. 2006) 3

Products for XXYLT1 Gene

Sources for XXYLT1 Gene

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