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Aliases for XXYLT1 Gene

Aliases for XXYLT1 Gene

  • Xyloside Xylosyltransferase 1 2 3 5
  • UDP-Xylose:Alpha-Xyloside Alpha-1,3-Xylosyltransferase 3 4
  • C3orf21 3 4
  • Chromosome 3 Open Reading Frame 21 2
  • EC 2.4.2.n3 4

External Ids for XXYLT1 Gene

Previous HGNC Symbols for XXYLT1 Gene

  • C3orf21

Previous GeneCards Identifiers for XXYLT1 Gene

  • GC03M194790

Summaries for XXYLT1 Gene

GeneCards Summary for XXYLT1 Gene

XXYLT1 (Xyloside Xylosyltransferase 1) is a Protein Coding gene. GO annotations related to this gene include transferase activity, transferring glycosyl groups and transferase activity, transferring pentosyl groups. An important paralog of this gene is B4GAT1.

UniProtKB/Swiss-Prot for XXYLT1 Gene

  • Alpha-1,3-xylosyltransferase, which elongates the O-linked xylose-glucose disaccharide attached to EGF-like repeats in the extracellular domain of Notch proteins by catalyzing the addition of the second xylose.

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for XXYLT1 Gene

Genomics for XXYLT1 Gene

Regulatory Elements for XXYLT1 Gene

Enhancers for XXYLT1 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around XXYLT1 on UCSC Golden Path with GeneCards custom track

Promoters for XXYLT1 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around XXYLT1 on UCSC Golden Path with GeneCards custom track

Genomic Location for XXYLT1 Gene

Chromosome:
3
Start:
195,068,276 bp from pter
End:
195,271,167 bp from pter
Size:
202,892 bases
Orientation:
Minus strand

Genomic View for XXYLT1 Gene

Genes around XXYLT1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
XXYLT1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for XXYLT1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for XXYLT1 Gene

Proteins for XXYLT1 Gene

  • Protein details for XXYLT1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8NBI6-XXLT1_HUMAN
    Recommended name:
    Xyloside xylosyltransferase 1
    Protein Accession:
    Q8NBI6
    Secondary Accessions:
    • D3DNW5
    • Q8NAL3
    • Q8WV03
    • Q96ME0

    Protein attributes for XXYLT1 Gene

    Size:
    393 amino acids
    Molecular mass:
    43807 Da
    Quaternary structure:
    • Monomer. Homodimer. Dimer formation may be essential for the retention in endoplasmic reticulum.
    SequenceCaution:
    • Sequence=AAH19036.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305};

    Alternative splice isoforms for XXYLT1 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for XXYLT1 Gene

Proteomics data for XXYLT1 Gene at MOPED

Post-translational modifications for XXYLT1 Gene

  • Ubiquitination at Lys 321
  • Glycosylation at Ser 67 and Ser 77
  • Modification sites at PhosphoSitePlus

Other Protein References for XXYLT1 Gene

No data available for DME Specific Peptides for XXYLT1 Gene

Domains & Families for XXYLT1 Gene

Gene Families for XXYLT1 Gene

Protein Domains for XXYLT1 Gene

Suggested Antigen Peptide Sequences for XXYLT1 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q8NBI6

UniProtKB/Swiss-Prot:

XXLT1_HUMAN :
  • Belongs to the glycosyltransferase 8 family.
Family:
  • Belongs to the glycosyltransferase 8 family.
genes like me logo Genes that share domains with XXYLT1: view

Function for XXYLT1 Gene

Molecular function for XXYLT1 Gene

UniProtKB/Swiss-Prot CatalyticActivity:
UDP-alpha-D-xylose + alpha-D-xylose-(1->3)-beta-D-glucosyl-R = UDP + alpha-D-xylose-(1->3)-alpha-D-xylose-(1->3)-beta-D-glucosyl-R.
UniProtKB/Swiss-Prot Function:
Alpha-1,3-xylosyltransferase, which elongates the O-linked xylose-glucose disaccharide attached to EGF-like repeats in the extracellular domain of Notch proteins by catalyzing the addition of the second xylose.

Enzyme Numbers (IUBMB) for XXYLT1 Gene

Phenotypes for XXYLT1 Gene

genes like me logo Genes that share phenotypes with XXYLT1: view

Animal Models for XXYLT1 Gene

MGI Knock Outs for XXYLT1:

Animal Model Products

CRISPR Products

miRNA for XXYLT1 Gene

No data available for Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for XXYLT1 Gene

Localization for XXYLT1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for XXYLT1 Gene

Endoplasmic reticulum membrane; Single-pass type II membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for XXYLT1 Gene COMPARTMENTS Subcellular localization image for XXYLT1 gene
Compartment Confidence
endoplasmic reticulum 4
cytosol 2
golgi apparatus 2
mitochondrion 2
lysosome 1
plasma membrane 1
vacuole 1

Gene Ontology (GO) - Cellular Components for XXYLT1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with XXYLT1: view

Pathways & Interactions for XXYLT1 Gene

SuperPathways for XXYLT1 Gene

No Data Available

Interacting Proteins for XXYLT1 Gene

STRING Interaction Network Preview (showing 2 interactants - click image to see details)
http://string-db.org/version_10/api/image/networkList?limit=0&targetmode=proteins&caller_identity=gene_cards&network_flavor=evidence&identifiers=9606.ENSP00000309640%0d%0a9606.ENSP00000344818%0d%0a9606.ENSP00000385269%0d%0a
Selected Interacting proteins: ENSP00000309640 for XXYLT1 Gene via STRING

SIGNOR curated interactions for XXYLT1 Gene

Activates:

Gene Ontology (GO) - Biological Process for XXYLT1 Gene

None

No data available for Pathways by source for XXYLT1 Gene

Drugs & Compounds for XXYLT1 Gene

(1) Drugs for XXYLT1 Gene - From: HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Uridine-5'-Diphosphate Experimental Pharma 0

(1) Additional Compounds for XXYLT1 Gene - From: HMDB

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
UDP-D-Xylose
  • alpha-D-Xylopyranosyl ester
  • alpha-delta-Xylopyranosyl ester
  • UDP Xylose
  • UDP-alpha
  • UDP-D-Xylose
3616-06-6
genes like me logo Genes that share compounds with XXYLT1: view

Transcripts for XXYLT1 Gene

Unigene Clusters for XXYLT1 Gene

Xyloside xylosyltransferase 1:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for XXYLT1 Gene

ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12 ^ 13a · 13b · 13c · 13d · 13e
SP1: - - - - -
SP2: - - - - - - - - -
SP3:
SP4: - - - -
SP5: - - -
SP6: - -
SP7: - - -

Relevant External Links for XXYLT1 Gene

GeneLoc Exon Structure for
XXYLT1
ECgene alternative splicing isoforms for
XXYLT1

Expression for XXYLT1 Gene

mRNA expression in normal human tissues for XXYLT1 Gene

Protein differential expression in normal tissues from HIPED for XXYLT1 Gene

This gene is overexpressed in Pancreas (27.2), Bone (16.9), and Plasma (11.9).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for XXYLT1 Gene



SOURCE GeneReport for Unigene cluster for XXYLT1 Gene Hs.478741

genes like me logo Genes that share expression patterns with XXYLT1: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Protein tissue co-expression partners for XXYLT1 Gene

Orthologs for XXYLT1 Gene

This gene was present in the common ancestor of animals.

Orthologs for XXYLT1 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia XXYLT1 35
  • 92.09 (n)
  • 95.66 (a)
XXYLT1 36
  • 84 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Xxylt1 35
  • 89.46 (n)
  • 91.84 (a)
Xxylt1 16
Xxylt1 36
  • 93 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia XXYLT1 35
  • 99.32 (n)
  • 99.24 (a)
XXYLT1 36
  • 99 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Xxylt1 35
  • 88.86 (n)
  • 92.09 (a)
dog
(Canis familiaris)
Mammalia XXYLT1 36
  • 93 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia XXYLT1 36
  • 77 (a)
OneToOne
chicken
(Gallus gallus)
Aves XXYLT1 35
  • 70.55 (n)
  • 71.04 (a)
lizard
(Anolis carolinensis)
Reptilia XXYLT1 36
  • 65 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia c3orf21 35
  • 68.54 (n)
  • 69.71 (a)
African clawed frog
(Xenopus laevis)
Amphibia Xl.19504 35
zebrafish
(Danio rerio)
Actinopterygii LOC100334669 35
  • 64.53 (n)
  • 62.4 (a)
XXYLT1 (1 of 2) 36
  • 60 (a)
OneToMany
XXYLT1 (2 of 2) 36
  • 60 (a)
OneToMany
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP007604 35
  • 55.02 (n)
  • 42.31 (a)
fruit fly
(Drosophila melanogaster)
Insecta CG11388 35
  • 54.43 (n)
  • 44.41 (a)
CG11388 36
  • 32 (a)
OneToOne
sea squirt
(Ciona savignyi)
Ascidiacea CSA.8510 36
  • 30 (a)
OneToOne
Species with no ortholog for XXYLT1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for XXYLT1 Gene

ENSEMBL:
Gene Tree for XXYLT1 (if available)
TreeFam:
Gene Tree for XXYLT1 (if available)

Paralogs for XXYLT1 Gene

Paralogs for XXYLT1 Gene

genes like me logo Genes that share paralogs with XXYLT1: view

Variants for XXYLT1 Gene

Sequence variations from dbSNP and Humsavar for XXYLT1 Gene

SNP ID Clin Chr 03 pos Sequence Context AA Info Type
rs721007 -- 195,182,929(+) TTCCT(A/C)AATCT intron-variant
rs729820 -- 195,200,602(+) CCTAC(A/G)ATCGG intron-variant
rs736919 -- 195,198,290(+) AAGGA(C/G)GAAGT intron-variant
rs736920 -- 195,198,340(+) TCCCA(C/T)TCCCC intron-variant
rs750469 -- 195,157,511(-) TCTTA(A/G)GTGCC intron-variant

Variation tolerance for XXYLT1 Gene

Residual Variation Intolerance Score: 73.5% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.99; 49.74% of all genes are more intolerant (likely to be disease-causing)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot , Structural Variations from Database of Genomic Variants (DGV) and Relevant External Links for XXYLT1 Gene

Disorders for XXYLT1 Gene

Relevant External Links for XXYLT1

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
XXYLT1

No disorders were found for XXYLT1 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for XXYLT1 Gene

Publications for XXYLT1 Gene

  1. Molecular cloning of a xylosyltransferase that transfers the second xylose to O-glucosylated epidermal growth factor repeats of Notch. (PMID: 22117070) Sethi M.K. … Bakker H. (J. Biol. Chem. 2012) 2 3 4 67
  2. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 3
  3. Insights into RNA biology from an atlas of mammalian mRNA-binding proteins. (PMID: 22658674) Castello A. … Hentze M.W. (Cell 2012) 3
  4. A genome-wide association study reveals susceptibility variants for non-small cell lung cancer in the Korean population. (PMID: 20876614) Yoon K.A. … Lee J.S. (Hum. Mol. Genet. 2010) 3
  5. Dynamics of cullin-RING ubiquitin ligase network revealed by systematic quantitative proteomics. (PMID: 21145461) Bennett E.J. … Harper J.W. (Cell 2010) 3

Products for XXYLT1 Gene

Sources for XXYLT1 Gene

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