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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

XRRA1 Gene

protein-coding   GIFtS: 43
GCID: GC11M074518

X-Ray Radiation Resistance Associated 1

  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
X-Ray Radiation Resistance Associated 11 2
X-Ray Radiation Resistance-Associated Protein 12

External Ids:    HGNC: 188681   Entrez Gene: 1435702   Ensembl: ENSG000001664357   OMIM: 6097885   UniProtKB: Q6P2D83   

Export aliases for XRRA1 gene to outside databases

Previous GC identifers: GC11M074741 GC11M074280 GC11M074252 GC11M074229 GC11M074551 GC11M070848


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

GeneCards Summary for XRRA1 Gene: 
XRRA1 (X-ray radiation resistance associated 1) is a protein-coding gene. Diseases associated with XRRA1 include neuroblastoma, and colorectal cancer. GO annotations related to this gene include molecular_function.

UniProtKB/Swiss-Prot: XRRA1_HUMAN, Q6P2D8
Function: May be involved in the response of cells to X-ray radiation




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000011.9  NT_167190.1  NC_018922.2  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the XRRA1 gene promoter:
         E2F-4   E2F-3a   E2F-5   HOXA3   COUP   Nkx2-5   E2F-2   E2F   E2F-1   STAT3   
         Other transcription factors

Browse SwitchGear Promoter luciferase reporter plasmids
   Search SABiosciences Chromatin IP Primers for XRRA1

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat XRRA1


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 11q13.4   Ensembl cytogenetic band:  11q13.4   HGNC cytogenetic band: 11q13.4

XRRA1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
XRRA1 gene location

GeneLoc information about chromosome 11         GeneLoc Exon Structure

GeneLoc location for GC11M074518:  view genomic region     (about GC identifiers)

Start:
74,518,784 bp from pter      End:
74,660,245 bp from pter
Size:
141,462 bases      Orientation:
minus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: XRRA1_HUMAN, Q6P2D8 (See protein sequence)
Recommended Name: X-ray radiation resistance-associated protein 1  
Size: 792 amino acids; 89864 Da
Subcellular location: Cytoplasm. Nucleus
Sequence caution: Sequence=AAO23657.1; Type=Frameshift; Positions=327; Sequence=AAP97315.1; Type=Frameshift;
Positions=327;
Secondary accessions: B5MD90 J3KNJ1 Q7RTT7 Q7Z463 Q7Z4U0
Alternative splicing: 5 isoforms:  Q6P2D8-1   Q6P2D8-2   Q6P2D8-3   Q6P2D8-4   Q6P2D8-5   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for XRRA1: NX_Q6P2D8

Explore proteomics data for XRRA1 at MOPED 

Post-translational modifications:

  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_Q6P2D8

  • XRRA1 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    XRRA1 Protein Expression
    REFSEQ proteins (3 alternative transcripts): 
    NP_001257309.1  NP_001257310.1  NP_892014.1  

    ENSEMBL proteins: 
     ENSP00000436390   ENSP00000339918   ENSP00000319303   ENSP00000433431   ENSP00000432689  
     ENSP00000435838   ENSP00000437334   ENSP00000435662   ENSP00000433940  

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    Cloud-Clone Corp. Proteins for XRRA1 

    Gene Ontology (GO): 2 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus IDA12908878
    GO:0005737cytoplasm IDA12908878

    XRRA1 for ontologies           About GeneDecksing



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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    1 InterPro protein domain:
     IPR001611 Leu-rich_rpt

    Graphical View of Domain Structure for InterPro Entry Q6P2D8

    ProtoNet protein and cluster: Q6P2D8

    1 Blocks protein domain: IPB001611 Leucine-rich repeat signature

    UniProtKB/Swiss-Prot: XRRA1_HUMAN, Q6P2D8
    Similarity: Contains 6 LRR (leucine-rich) repeats


    XRRA1 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: XRRA1_HUMAN, Q6P2D8
    Function: May be involved in the response of cells to X-ray radiation
    Induction: By X-ray irradiation immediately after exposure and is then down-regulated two-fold in an X-ray
    radiation-resistant cell clone. Responds differently to X-ray radiation in clones of varying radiation responses

         Gene Ontology (GO): 2 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003674molecular_function ND--
    GO:0005515protein binding ----
         
    XRRA1 for ontologies           About GeneDecksing


    Animal Models:
       inGenious Targeting Laboratory - Custom generated mouse model solutions for XRRA1 
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       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for XRRA1 
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    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section



    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for XRRA1

    Gene Ontology (GO): 1 biological process term (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0010165response to X-ray IDA12908878

    XRRA1 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for XRRA1

    Search CenterWatch for drugs/clinical trials and news about XRRA1

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for XRRA1 gene (3 alternative transcripts): 
    NM_001270380.1  NM_001270381.1  NM_182969.2  

    Unigene Cluster for XRRA1:

    X-ray radiation resistance associated 1
    Hs.370145  [show with all ESTs]
    Unigene Representative Sequence: NM_182969
    18/20 Ensembl transcripts including schematic representations, and UCSC links where relevant (see all 20):
    ENST00000530562(uc001ovm.2) ENST00000340360(uc001ovt.2 uc001ovo.3 uc009yub.3 uc001ovp.4 uc001ovq.4)
    ENST00000321448(uc001ovn.3) ENST00000531849(uc001ovr.2) ENST00000531449
    ENST00000527087 ENST00000431210(uc001ovs.1) ENST00000530280 ENST00000529926
    ENST00000528819 ENST00000525407 ENST00000528219 ENST00000526047 ENST00000531852
    ENST00000533598 ENST00000534041 ENST00000534798 ENST00000529400
    miRNA
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    8/37 QIAGEN miScript miRNA Assays for microRNAs that regulate XRRA1 (see all 37):
    hsa-miR-4272 hsa-miR-106a hsa-miR-624* hsa-miR-16-1* hsa-miR-519a hsa-miR-93 hsa-miR-520g hsa-miR-3148
    Browse SwitchGear 3'UTR luciferase reporter plasmids
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    Additional mRNA sequence: 

    AF439934.1 AK056364.1 AK074152.1 AK091449.1 AY163836.1 BC037294.2 BC040541.1 BC064584.1 

    13 DOTS entries:

    DT.95218489  DT.443902  DT.120758595  DT.100830578  DT.101981739  DT.97780810  DT.120758620  DT.100791297 
    DT.75100277  DT.97822839  DT.95331481  DT.40245026  DT.91685297 

    12 AceView cDNA sequences:

    BX424368 BX491147 BM921116 BU688666 BE780143 BX421492 AA331659 CD109566 
    AA331242 BE783661 CF593770 AW962535 

    GeneLoc Exon Structure

    5/6 Alternative Splicing Database (ASD) splice patterns (SP) for XRRA1 (see all 6)    About this scheme

    ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7a · 7b ^ 8 ^ 9a · 9b ^ 10a · 10b ^ 11a · 11b ^ 12 ^ 13a · 13b ^ 14 ^ 15a · 15b ^ 16 ^ 17 ^ 18 ^ 19a · 19b
    SP1:                                                  -           -                 -     -     -     -     -                                   -               
    SP2:                                                              -                 -                                                                           
    SP3:                                                                                -     -     -                                                               
    SP4:                                                                                            -     -     -     -                                             
    SP5:                                                                                                                                                            


    ECgene alternative splicing isoforms for XRRA1

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    XRRA1 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: TATTCAGGGG
    XRRA1 Expression
    About this image


    See XRRA1 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for XRRA1

    SOURCE GeneReport for Unigene cluster: Hs.370145

    UniProtKB/Swiss-Prot: XRRA1_HUMAN, Q6P2D8
    Tissue specificity: Expressed predominantly in testis followed by prostate and ovary. Low levels found in other
    tissues including peripheral blood leukocytes, spleen, thymus, small intestine and colon. Also expressed in
    neuroblastoma, glioma, breast, lung, leukemia, renal, ovarian, prostate and colorectal cancer cell lines

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    In Situ
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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of chordates.

    Orthologs for XRRA1 gene from 4/11 species (see all 11)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Xrra11 , 5 X-ray radiation resistance associated 11, 5 80.13(n)1
    74.32(a)1
      7 (54.15 cM)5
    4461011  NM_001164258.11  NP_001157730.11 
     998592185 
    chicken
    (Gallus gallus)
    Aves XRRA16
    X-ray radiation resistance associated 1
    40(a)
    1 ↔ 1
    1(194938172-194949182)
    lizard
    (Anolis carolinensis)
    Reptilia XRRA16
    Uncharacterized protein
    37(a)
    1 ↔ 1
    GL343489.1(457156-483576)
    zebrafish
    (Danio rerio)
    Actinopterygii LOC1005363251 x-ray radiation resistance-associated protein 1-like 47.64(n)
    38.45(a)
      100536325  XM_003200866.1  XP_003200914.1 


    ENSEMBL Gene Tree for XRRA1 (if available)
    TreeFam Gene Tree for XRRA1 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for XRRA1 gene
    2 SIMAP similar genes for XRRA1 using alignment to 7 protein entries:     XRRA1_HUMAN (see all proteins):
    DKFZp686K09128    FLJ00225

    XRRA1 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/1864 SNPs in XRRA1 are shown (see all 1864)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 11 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1470223691,2
    C--74553989(+) AAGAA-/AGAATGC 3 -- ut310--------
    rs5176661,2
    C,F,A,H--74554147(-) CCGGCC/TACAGG 3 -- ut31 ese321Minor allele frequency- T:0.23MN EA NS NA WA 4202
    rs2022448931,2
    C--74554292(+) ATCCAC/TGAACT 5 M V mis1 ut310--------
    rs1868963471,2
    C--74554368(+) GTCCCA/GAACAC 5 F syn1 ut310--------
    rs1487185351,2
    C--74554408(+) GGTAAC/TGTGCC 5 H R mis1 ut310--------
    rs1497774281,2
    --74554418(+) TGGAA-/CCTCCT 5 F VP fra1 ut310--------
    rs2008577511,2
    C--74554472(+) CCGCCA/GTTCTG 6 R W N mis1 syn10--------
    rs2005613991,2
    C--74554495(+) GGACAA/GCACCT 6 A V L mis1 syn10--------
    rs6932751,2
    C,F,H--74554672(+) CCCCTA/CTGCAT 3 -- int120Minor allele frequency- C:0.07NS EA NA 2638
    rs1508489591,2
    --74554789(+) ATGTAC/GGCAGT 3 -- int10--------

    HapMap Linkage Disequilibrium report for XRRA1 (74518784 - 74660245 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 4 variations for XRRA1:    About this table     
    Variant IDTypeSubtypePubMed ID
    nsv8840CNV Loss18304495
    dgv1223n71CNV Gain21882294
    nsv832210CNV Gain+Loss17160897
    dgv397e1CNV Complex17122850

    SABiosciences Cancer Mutation PCR Assays
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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 609788    OMIM disorders: --

    4 diseases for XRRA1:    About MalaCards
    neuroblastoma    colorectal cancer    leukemia    prostatitis


    XRRA1 for disorders           About GeneDecksing


    Export disorders for XRRA1 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for XRRA1 gene integrated from 9 sources:
    (articles sorted by number of sources associating them with XRRA1)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Molecular cloning, genomic characterization and over-expression of a novel gene, XRRA1, identified from human colorectal cancer cell HCT116Clone2_XRR and macaque testis. (PubMed id 12908878)1, 2, 3 Mesak F.M.... Ng C.E. (2003)
    2. Diesel exhaust particles disturb gene expression in mouse testis. (PubMed id 17295261)1, 3 Mori T....Kashiwagura T. (2007)
    3. A germline-specific class of small RNAs binds mammali an Piwi proteins. (PubMed id 16751776)1 Girard A....Carmell M.A. (2006)
    4. Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. (PubMed id 16344560)1 Kimura K.... Sugano S. (2006)
    5. Human chromosome 11 DNA sequence and analysis including novel gene identification. (PubMed id 16554811)2 Taylor T.D....Sakaki Y. (2006)
    6. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)2 Gerhard D.S....Malek J. (2004)
    7. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1 Ota T.... Sugano S. (2004)
    8. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (2002)

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    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 143570 HGNC: 18868 AceView: XRRA1.1 Ensembl:ENSG00000166435 euGenes: HUgn143570
    ECgene: XRRA1 H-InvDB: XRRA1

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for XRRA1 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for XRRA1 gene:
    Search GeneIP for patents involving XRRA1

    GeneCards and IP:
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