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Aliases for XRRA1 Gene

Aliases for XRRA1 Gene

  • X-Ray Radiation Resistance Associated 1 2 3 5

External Ids for XRRA1 Gene

Previous GeneCards Identifiers for XRRA1 Gene

  • GC11M074741
  • GC11M074280
  • GC11M074252
  • GC11M074229
  • GC11M074551
  • GC11M070848
  • GC11M074518

Summaries for XRRA1 Gene

GeneCards Summary for XRRA1 Gene

XRRA1 (X-Ray Radiation Resistance Associated 1) is a Protein Coding gene.

UniProtKB/Swiss-Prot for XRRA1 Gene

  • May be involved in the response of cells to X-ray radiation.

Additional gene information for XRRA1 Gene

No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for XRRA1 Gene

Genomics for XRRA1 Gene

Regulatory Elements for XRRA1 Gene

Enhancers for XRRA1 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH11H074948 1.4 ENCODE dbSUPER 125 -2.3 -2252 6 HDGF PKNOX1 FOXA2 MLX ARNT ARID4B SIN3A FEZF1 DMAP1 ZNF2 XRRA1 SPCS2 RNU6-216P GC11M074969
GH11H075029 1.6 FANTOM5 Ensembl ENCODE 103.5 -82.0 -82006 3 HDGF PKNOX1 ATF1 ARNT ARID4B ZNF2 TCF12 ZNF766 GATA2 ELK1 XRRA1 P4HA3 OR2AT4 SLCO2B1 ENSG00000206913 POLD3 ARRB1 PIR37723 PIR50270
GH11H074747 1.1 ENCODE 119.2 +200.1 200141 2 HDGF PKNOX1 ARNT ZFP64 ARID4B SIN3A DMAP1 YBX1 ZNF2 YY1 XRRA1 ARPC3P4 RNF169 OR2AT1P ENSG00000254460 ENSG00000254630 RPS3 ENSG00000206913 C2CD3 POLD3
GH11H074783 1 Ensembl ENCODE 122 +165.2 165247 2 PKNOX1 JUN JUNB MAX BATF RELA JUND POLR2A EED IKZF1 XRRA1 RNF169 ENSG00000278879
GH11H075012 1.2 Ensembl ENCODE 100.8 -64.4 -64448 2 PKNOX1 FOXA2 TBL1XR1 RARA TCF12 EGR1 FOS CEBPB ZEB2 REST XRRA1 NEU3 PIR50270 PIR52683
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around XRRA1 on UCSC Golden Path with GeneCards custom track

Promoters for XRRA1 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000042061 -200 2401 HDGF PKNOX1 MLX ARNT ARID4B SIN3A FEZF1 DMAP1 ZNF2 ZBTB7B

Genomic Location for XRRA1 Gene

Chromosome:
11
Start:
74,807,739 bp from pter
End:
74,949,200 bp from pter
Size:
141,462 bases
Orientation:
Minus strand

Genomic View for XRRA1 Gene

Genes around XRRA1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
XRRA1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for XRRA1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for XRRA1 Gene

Proteins for XRRA1 Gene

  • Protein details for XRRA1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q6P2D8-XRRA1_HUMAN
    Recommended name:
    X-ray radiation resistance-associated protein 1
    Protein Accession:
    Q6P2D8
    Secondary Accessions:
    • B5MD90
    • J3KNJ1
    • Q7RTT7
    • Q7Z463
    • Q7Z4U0

    Protein attributes for XRRA1 Gene

    Size:
    792 amino acids
    Molecular mass:
    89864 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=AAO23657.1; Type=Frameshift; Positions=327; Evidence={ECO:0000305}; Sequence=AAP97315.1; Type=Frameshift; Positions=327; Evidence={ECO:0000305};

    Alternative splice isoforms for XRRA1 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for XRRA1 Gene

Post-translational modifications for XRRA1 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for XRRA1 Gene

Domains & Families for XRRA1 Gene

Gene Families for XRRA1 Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Protein Domains for XRRA1 Gene

Suggested Antigen Peptide Sequences for XRRA1 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with XRRA1: view

No data available for UniProtKB/Swiss-Prot for XRRA1 Gene

Function for XRRA1 Gene

Molecular function for XRRA1 Gene

UniProtKB/Swiss-Prot Function:
May be involved in the response of cells to X-ray radiation.
UniProtKB/Swiss-Prot Induction:
By X-ray irradiation immediately after exposure and is then down-regulated two-fold in an X-ray radiation-resistant cell clone. Responds differently to X-ray radiation in clones of varying radiation responses.

Gene Ontology (GO) - Molecular Function for XRRA1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003674 molecular_function ND --
genes like me logo Genes that share ontologies with XRRA1: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

No data available for Enzyme Numbers (IUBMB) , Phenotypes From GWAS Catalog , Phenotypes , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for XRRA1 Gene

Localization for XRRA1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for XRRA1 Gene

Cytoplasm. Nucleus.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for XRRA1 gene
Compartment Confidence
nucleus 5
cytosol 2

Subcellular locations from the

Human Protein Atlas (HPA)
  • Nuclear bodies (3)
  • Nucleoplasm (3)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for XRRA1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IDA,IEA 12908878
GO:0005654 nucleoplasm IDA --
GO:0005737 cytoplasm IDA,IEA 12908878
GO:0016604 nuclear body IDA --
genes like me logo Genes that share ontologies with XRRA1: view

Pathways & Interactions for XRRA1 Gene

SuperPathways for XRRA1 Gene

No Data Available

Gene Ontology (GO) - Biological Process for XRRA1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0010165 response to X-ray IDA 12908878
genes like me logo Genes that share ontologies with XRRA1: view

No data available for Pathways by source and SIGNOR curated interactions for XRRA1 Gene

Drugs & Compounds for XRRA1 Gene

No Compound Related Data Available

Transcripts for XRRA1 Gene

Unigene Clusters for XRRA1 Gene

X-ray radiation resistance associated 1:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Alternative Splicing Database (ASD) splice patterns (SP) for XRRA1 Gene

ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7a · 7b ^ 8 ^ 9a · 9b ^ 10a · 10b ^ 11a · 11b ^ 12 ^ 13a · 13b ^ 14 ^ 15a · 15b ^ 16 ^ 17 ^ 18 ^ 19a · 19b
SP1: - - - - - - - -
SP2: - -
SP3: - - -
SP4: - - - -
SP5:
SP6: -

Relevant External Links for XRRA1 Gene

GeneLoc Exon Structure for
XRRA1
ECgene alternative splicing isoforms for
XRRA1

Expression for XRRA1 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for XRRA1 Gene

mRNA differential expression in normal tissues according to GTEx for XRRA1 Gene

This gene is overexpressed in Testis (x6.8).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for XRRA1 Gene



Protein tissue co-expression partners for XRRA1 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of XRRA1 Gene:

XRRA1

SOURCE GeneReport for Unigene cluster for XRRA1 Gene:

Hs.370145

mRNA Expression by UniProt/SwissProt for XRRA1 Gene:

Q6P2D8-XRRA1_HUMAN
Tissue specificity: Expressed predominantly in testis followed by prostate and ovary. Low levels found in other tissues including peripheral blood leukocytes, spleen, thymus, small intestine and colon. Also expressed in neuroblastoma, glioma, breast, lung, leukemia, renal, ovarian, prostate and colorectal cancer cell lines.

Evidence on tissue expression from TISSUES for XRRA1 Gene

  • Nervous system(2.4)
genes like me logo Genes that share expression patterns with XRRA1: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , Protein differential expression in normal tissues and Phenotype-based relationships between genes and organs from Gene ORGANizer for XRRA1 Gene

Orthologs for XRRA1 Gene

This gene was present in the common ancestor of chordates.

Orthologs for XRRA1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia XRRA1 33 34
  • 99.28 (n)
dog
(Canis familiaris)
Mammalia XRRA1 33 34
  • 82.71 (n)
mouse
(Mus musculus)
Mammalia Xrra1 33 16 34
  • 80.22 (n)
rat
(Rattus norvegicus)
Mammalia Xrra1 33
  • 79.64 (n)
cow
(Bos Taurus)
Mammalia XRRA1 34
  • 77 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia XRRA1 34
  • 52 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia XRRA1 34
  • 30 (a)
OneToOne
chicken
(Gallus gallus)
Aves LOC769715 33
  • 54.09 (n)
XRRA1 34
  • 40 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia XRRA1 34
  • 38 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia LOC100493426 33
  • 54.18 (n)
zebrafish
(Danio rerio)
Actinopterygii xrra1 33 34
  • 48.84 (n)
sea squirt
(Ciona savignyi)
Ascidiacea -- 34
  • 41 (a)
OneToOne
Species where no ortholog for XRRA1 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for XRRA1 Gene

ENSEMBL:
Gene Tree for XRRA1 (if available)
TreeFam:
Gene Tree for XRRA1 (if available)

Paralogs for XRRA1 Gene

(2) SIMAP similar genes for XRRA1 Gene using alignment to 7 proteins:

genes like me logo Genes that share paralogs with XRRA1: view

No data available for Paralogs for XRRA1 Gene

Variants for XRRA1 Gene

Sequence variations from dbSNP and Humsavar for XRRA1 Gene

SNP ID Clin Chr 11 pos Sequence Context AA Info Type
rs1000003493 -- 74,900,279(+) AACAG(C/T)ATATT intron-variant
rs1000011833 -- 74,949,044(+) GCCTG(C/G)CGCTA upstream-variant-2KB, utr-variant-5-prime
rs1000060760 -- 74,867,575(+) ATTAT(A/G)TAAAG intron-variant
rs1000074357 -- 74,861,626(+) GTACA(C/T)AATAA intron-variant
rs1000135373 -- 74,914,725(+) TTTTT(G/T)AAAAA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for XRRA1 Gene

Variant ID Type Subtype PubMed ID
esv2759837 CNV gain 17122850
nsv478467 CNV novel sequence insertion 20440878
nsv832210 CNV gain+loss 17160897
nsv8840 CNV loss 18304495
nsv972046 CNV duplication 23825009

Variation tolerance for XRRA1 Gene

Residual Variation Intolerance Score: 95.2% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 5.92; 74.42% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for XRRA1 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
XRRA1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for XRRA1 Gene

Disorders for XRRA1 Gene

Relevant External Links for XRRA1

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
XRRA1

No disorders were found for XRRA1 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for XRRA1 Gene

Publications for XRRA1 Gene

  1. Molecular cloning, genomic characterization and over-expression of a novel gene, XRRA1, identified from human colorectal cancer cell HCT116Clone2_XRR and macaque testis. (PMID: 12908878) Mesak FM … Ng CE (BMC genomics 2003) 2 3 4 60
  2. Diesel exhaust particles disturb gene expression in mouse testis. (PMID: 17295261) Mori T … Kashiwagura T (Environmental toxicology 2007) 2 3 60
  3. A Global Analysis of the Receptor Tyrosine Kinase-Protein Phosphatase Interactome. (PMID: 28065597) Yao Z … Stagljar I (Molecular cell 2016) 3 60
  4. Insights into RNA biology from an atlas of mammalian mRNA-binding proteins. (PMID: 22658674) Castello A … Hentze MW (Cell 2012) 3 60
  5. Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. (PMID: 16344560) Kimura K … Sugano S (Genome research 2006) 3 60

Products for XRRA1 Gene

Sources for XRRA1 Gene

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