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Aliases for XRRA1 Gene

Aliases for XRRA1 Gene

  • X-Ray Radiation Resistance Associated 1 2 3 5

External Ids for XRRA1 Gene

Previous GeneCards Identifiers for XRRA1 Gene

  • GC11M074741
  • GC11M074280
  • GC11M074252
  • GC11M074229
  • GC11M074551
  • GC11M070848
  • GC11M074518

Summaries for XRRA1 Gene

GeneCards Summary for XRRA1 Gene

XRRA1 (X-Ray Radiation Resistance Associated 1) is a Protein Coding gene.

UniProtKB/Swiss-Prot for XRRA1 Gene

  • May be involved in the response of cells to X-ray radiation.

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for XRRA1 Gene

Genomics for XRRA1 Gene

Regulatory Elements for XRRA1 Gene

Enhancers for XRRA1 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH11F074948 0.9 Ensembl ENCODE 125 -2.3 -2252 6.6 HDGF PKNOX1 CREB3L1 MLX WRNIP1 ARID4B SIN3A FEZF1 DMAP1 ZNF2 XRRA1 ENSG00000255434 LOC105369391 SERPINH1 ENSG00000254837 MAP6 PPME1 SPCS2 GC11M074969 RNU6-216P
GH11F074931 0.6 ENCODE 124.9 +16.4 16407 1.9 ATF1 JUN DDX20 ZNF175 PTRF CEBPG CHAMP1 IRF9 ZNF766 ZNF584 XRRA1 SLCO2B1 RPL31P46
GH11F074781 1.1 Ensembl ENCODE 121.9 +165.8 165800 3.6 PKNOX1 CREB3L1 ARID4B SIN3A DMAP1 YY1 ZNF207 FOS KLF13 DEK XRRA1 RNF169 RPS12P22 ARRB1 ENSG00000278879
GH11F074768 1 Ensembl ENCODE 121.7 +179.6 179560 3.3 HDGF PKNOX1 TAL1 JUN ZNF175 CEBPG RELA IRF9 ZNF316 NCOR1 XRRA1 RNF169 ENSG00000278879
GH11F074747 0.2 ENCODE 119.2 +200.1 200141 2.9 HDGF PKNOX1 ARNT CREB3L1 WRNIP1 ZFP64 ARID4B SIN3A YBX1 DMAP1 XRRA1 OR2AT1P ENSG00000254460 ENSG00000254630 P4HA3 LOC101928580 ARPC3P4 RNF169 ENSG00000278879
- Elite enhancer/Elite enhancer-gene association Download Table
Download GeneHancer data dump

Enhancers around XRRA1 on UCSC Golden Path with GeneCards custom track

Promoters for XRRA1 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

Genomic Location for XRRA1 Gene

74,807,739 bp from pter
74,949,200 bp from pter
141,462 bases
Minus strand

Genomic View for XRRA1 Gene

Genes around XRRA1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
XRRA1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for XRRA1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for XRRA1 Gene

Proteins for XRRA1 Gene

  • Protein details for XRRA1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    X-ray radiation resistance-associated protein 1
    Protein Accession:
    Secondary Accessions:
    • B5MD90
    • J3KNJ1
    • Q7RTT7
    • Q7Z463
    • Q7Z4U0

    Protein attributes for XRRA1 Gene

    792 amino acids
    Molecular mass:
    89864 Da
    Quaternary structure:
    No Data Available
    • Sequence=AAO23657.1; Type=Frameshift; Positions=327; Evidence={ECO:0000305}; Sequence=AAP97315.1; Type=Frameshift; Positions=327; Evidence={ECO:0000305};

    Alternative splice isoforms for XRRA1 Gene


neXtProt entry for XRRA1 Gene

Post-translational modifications for XRRA1 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for XRRA1 Gene

Domains & Families for XRRA1 Gene

Protein Domains for XRRA1 Gene

Suggested Antigen Peptide Sequences for XRRA1 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Contains 6 LRR (leucine-rich) repeats.
  • Contains 6 LRR (leucine-rich) repeats.
genes like me logo Genes that share domains with XRRA1: view

No data available for Gene Families for XRRA1 Gene

Function for XRRA1 Gene

Molecular function for XRRA1 Gene

UniProtKB/Swiss-Prot Function:
May be involved in the response of cells to X-ray radiation.
UniProtKB/Swiss-Prot Induction:
By X-ray irradiation immediately after exposure and is then down-regulated two-fold in an X-ray radiation-resistant cell clone. Responds differently to X-ray radiation in clones of varying radiation responses.

Gene Ontology (GO) - Molecular Function for XRRA1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003674 molecular_function ND --
genes like me logo Genes that share ontologies with XRRA1: view

Animal Model Products

Inhibitory RNA Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Phenotypes , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for XRRA1 Gene

Localization for XRRA1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for XRRA1 Gene

Cytoplasm. Nucleus.

Subcellular locations from

Jensen Localization Image for XRRA1 Gene COMPARTMENTS Subcellular localization image for XRRA1 gene
Compartment Confidence
nucleus 5
cytosol 2

Gene Ontology (GO) - Cellular Components for XRRA1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IEA,IDA 12908878
GO:0005737 cytoplasm IEA,IDA 12908878
genes like me logo Genes that share ontologies with XRRA1: view

Pathways & Interactions for XRRA1 Gene

SuperPathways for XRRA1 Gene

No Data Available

Interacting Proteins for XRRA1 Gene

Gene Ontology (GO) - Biological Process for XRRA1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0010165 response to X-ray IDA 12908878
genes like me logo Genes that share ontologies with XRRA1: view

No data available for Pathways by source and SIGNOR curated interactions for XRRA1 Gene

Transcripts for XRRA1 Gene

mRNA/cDNA for XRRA1 Gene

Unigene Clusters for XRRA1 Gene

X-ray radiation resistance associated 1:
Representative Sequences:

Inhibitory RNA Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for XRRA1 Gene

ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7a · 7b ^ 8 ^ 9a · 9b ^ 10a · 10b ^ 11a · 11b ^ 12 ^ 13a · 13b ^ 14 ^ 15a · 15b ^ 16 ^ 17 ^ 18 ^ 19a · 19b
SP1: - - - - - - - -
SP2: - -
SP3: - - -
SP4: - - - -
SP6: -

Relevant External Links for XRRA1 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for XRRA1 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for XRRA1 Gene

mRNA differential expression in normal tissues according to GTEx for XRRA1 Gene

This gene is overexpressed in Testis (x6.8).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for XRRA1 Gene

Protein tissue co-expression partners for XRRA1 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of XRRA1 Gene:


SOURCE GeneReport for Unigene cluster for XRRA1 Gene:


mRNA Expression by UniProt/SwissProt for XRRA1 Gene:

Tissue specificity: Expressed predominantly in testis followed by prostate and ovary. Low levels found in other tissues including peripheral blood leukocytes, spleen, thymus, small intestine and colon. Also expressed in neuroblastoma, glioma, breast, lung, leukemia, renal, ovarian, prostate and colorectal cancer cell lines.
genes like me logo Genes that share expression patterns with XRRA1: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and Protein differential expression in normal tissues for XRRA1 Gene

Orthologs for XRRA1 Gene

This gene was present in the common ancestor of chordates.

Orthologs for XRRA1 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia XRRA1 34 35
  • 99.28 (n)
(Canis familiaris)
Mammalia XRRA1 34 35
  • 82.71 (n)
(Mus musculus)
Mammalia Xrra1 34 16 35
  • 80.22 (n)
(Rattus norvegicus)
Mammalia Xrra1 34
  • 79.64 (n)
(Bos Taurus)
Mammalia XRRA1 35
  • 77 (a)
(Monodelphis domestica)
Mammalia XRRA1 35
  • 52 (a)
(Ornithorhynchus anatinus)
Mammalia XRRA1 35
  • 30 (a)
(Gallus gallus)
Aves LOC769715 34
  • 54.09 (n)
XRRA1 35
  • 40 (a)
(Anolis carolinensis)
Reptilia XRRA1 35
  • 38 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia LOC100493426 34
  • 54.18 (n)
(Danio rerio)
Actinopterygii xrra1 34 35
  • 48.84 (n)
sea squirt
(Ciona savignyi)
Ascidiacea -- 35
  • 41 (a)
Species where no ortholog for XRRA1 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for XRRA1 Gene

Gene Tree for XRRA1 (if available)
Gene Tree for XRRA1 (if available)

Paralogs for XRRA1 Gene

(2) SIMAP similar genes for XRRA1 Gene using alignment to 7 proteins:

genes like me logo Genes that share paralogs with XRRA1: view

No data available for Paralogs for XRRA1 Gene

Variants for XRRA1 Gene

Sequence variations from dbSNP and Humsavar for XRRA1 Gene

SNP ID Clin Chr 11 pos Sequence Context AA Info Type
rs10128626 -- 74,883,482(+) tcgct(C/G)acgct intron-variant
rs10160407 -- 74,870,959(+) gggga(C/T)gtaat intron-variant
rs10160410 -- 74,871,086(+) tgtta(C/T)atagt intron-variant
rs10160417 -- 74,871,425(+) tcaag(G/T)gcatt intron-variant
rs10501418 -- 74,855,434(-) ATACC(A/G)CACAC intron-variant

Structural Variations from Database of Genomic Variants (DGV) for XRRA1 Gene

Variant ID Type Subtype PubMed ID
esv2759837 CNV gain 17122850
nsv478467 CNV novel sequence insertion 20440878
nsv832210 CNV gain+loss 17160897
nsv8840 CNV loss 18304495
nsv972046 CNV duplication 23825009

Variation tolerance for XRRA1 Gene

Residual Variation Intolerance Score: 95.2% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 5.92; 74.42% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for XRRA1 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for XRRA1 Gene

Disorders for XRRA1 Gene

Relevant External Links for XRRA1

Atlas of Genetics and Cytogenetics in Oncology and Haematology:

No disorders were found for XRRA1 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for XRRA1 Gene

Publications for XRRA1 Gene

  1. Molecular cloning, genomic characterization and over-expression of a novel gene, XRRA1, identified from human colorectal cancer cell HCT116Clone2_XRR and macaque testis. (PMID: 12908878) Mesak F.M. … Ng C.E. (BMC Genomics 2003) 2 3 4 64
  2. Diesel exhaust particles disturb gene expression in mouse testis. (PMID: 17295261) Mori T. … Kashiwagura T. (Environ. Toxicol. 2007) 2 3 64
  3. Insights into RNA biology from an atlas of mammalian mRNA-binding proteins. (PMID: 22658674) Castello A. … Hentze M.W. (Cell 2012) 3 64
  4. Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. (PMID: 16344560) Kimura K. … Sugano S. (Genome Res. 2006) 3 64
  5. A germline-specific class of small RNAs binds mammalian Piwi proteins. (PMID: 16751776) Girard A. … Carmell M.A. (Nature 2006) 3 64

Products for XRRA1 Gene

Sources for XRRA1 Gene

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