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Category Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21

GIFtS
-

XRN2 Gene

protein-coding GIFtS: 59
GCID: GC20P021283

5'-3' exoribonuclease 2

Explore 5 diseases affiliated with
XRN2 via

MalaCards

our new
Human Malady Compendium

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc, ⁷Ensembl, ⁸DME, ⁹miRBase, and/or ¹⁰fRNAdb)
About This Section

Aliases
5'-3' Exoribonuclease 2¹ ²
DHP Protein² ³
Dhm1-Like Protein (Mouse Homolog)²
EC 3.1.13.-³
DHM1-Like Protein³
EC 3.1.13⁸

External Ids:	HGNC: 12836¹	Entrez Gene: 22803²	Ensembl: ENSG00000088930⁷	OMIM: 608851⁵	UniProtKB: Q9H0D6³

Export aliases for XRN2 gene to outside databases

Previous GC identifers: GC20P021272 GC20P021278 GC20P021231

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for XRN2:

This gene shares similarity with the mouse Dhm1 and the yeast dhp1 gene. The yeast gene is involved in homologous

recombination and RNA metabolism, such as RNA synthesis and RNA trafficking. Complementation studies show that Dhm1

has a similar function in mouse as dhp1. The function of the human gene has not yet been determined. Transcript

variants encoding different isoforms have been noted for this gene; however, their full-length nature is not known.

(provided by RefSeq, Jul 2008)

UniProtKB/Swiss-Prot: XRN2_HUMAN, Q9H0D6

Function: Possesses 5'->3' exoribonuclease activity (By similarity). May promote the termination of transcription by

RNA polymerase II. During transcription termination, cleavage at the polyadenylation site liberates a 5' fragment

which is subsequently processed to form the mature mRNA and a 3' fragment which remains attached to the elongating

polymerase. The processive degradation of this 3' fragment by this protein may promote termination of transcription

Gene Wiki entry for XRN2 (5'-3' exoribonuclease 2)

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section

RefSeq DNA sequence:

NC_000020.10 NC_018931.1 NT_011387.8

Regulatory elements:

SABiosciences Regulatory transcription factor binding sites in the XRN2 gene promoter:
AP-2rep AML1a C/EBPalpha Egr-2 AREB6 CREB NRF-2 deltaCREB HSF2 c-Myb
Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 4): XRN2 promoter sequence

Search SABiosciences Chromatin IP Primers for XRN2

Epigenetics:

QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat XRN2

Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 20p11.2-p11.1 Ensembl cytogenetic band: 20p11.23 HGNC cytogenetic band: 20p11.2-p11.1

XRN2 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
XRN2 gene location

GeneLoc information about chromosome 20 GeneLoc Exon Structure

GeneLoc location for GC20P021283: view genomic region (about GC identifiers)

Start:	21,283,942 bp from pter	End:	21,370,463 bp from pter
Size:	86,522 bases	Orientation:	plus strand

(According to ¹UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to ²PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section

UniProtKB/Swiss-Prot: XRN2_HUMAN, Q9H0D6 (See protein sequence)

Recommended Name: 5'-3' exoribonuclease 2

Size: 950 amino acids; 108582 Da

Subcellular location: Nucleus, nucleolus

Sequence caution: Sequence=AAR24369.1; Type=Frameshift; Positions=73; Sequence=BAA90934.1; Type=Erroneous initiation;

Secondary accessions: Q3L8N4 Q6KGZ9 Q9BQL1 Q9NTW0 Q9NXS6 Q9UL53

Alternative splicing: 2 isoforms: Q9H0D6-1 Q9H0D6-2 (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for XRN2: NX_Q9H0D6

Post-translational modifications:

View modification sites using PhosphoSitePlus²

View neXtProt modification sites for NX_Q9H0D6

4/22 DME Specific Peptides for XRN2 (Q9H0D6) (see all 22)

KECNGVK

PNTHHCL

DFYPEDF

EDEMMVA

XRN2 Protein expression data from MOPED and PaxDb: About this image

REFSEQ proteins: NP_036387.2

ENSEMBL proteins:

ENSP00000366396 ENSP00000441113 ENSP00000413548

Reactome Protein details: Q9H0D6
Human Recombinant Protein Products:

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	Novus Biologicals XRN2 Protein Novus Biologicals XRN2 Lysate
	Browse Sino Biological Recombinant Proteins
	Browse ProSpec Recombinant Proteins
	Uscn Proteins for XRN2

Gene Ontology (GO): 3 cellular component terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005634	nucleus	IDA	--
GO:0005730	nucleolus	IDA	--
GO:0016235	aggresome	IDA	--

XRN2 for ontologies About GeneDecksing

XRN2 Antibody Products:

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Assay Products for XRN2:

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	Uscn ELISAs and CLIAs for XRN2

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

XRN2 for domains About GeneDecksing

4 InterPro domains/families:

IPR017151 5_3_exoribonuclease_2

IPR004859 Put_53exo

IPR027073 5_3_exoribonuclease

IPR001878 Znf_CCHC

Graphical View of Domain Structure for InterPro Entry Q9H0D6

ProtoNet protein and cluster: Q9H0D6

2 Blocks protein families:

IPB001878 C2HC-type zinc-finger signature

IPB004859 Putative 5-3 exonuclease domain

UniProtKB/Swiss-Prot: XRN2_HUMAN, Q9H0D6

Similarity: Belongs to the 5'-3' exonuclease family. XRN2/RAT1 subfamily

Similarity: Contains 1 CCHC-type zinc finger

(According to ¹UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or ²DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
About This Section

Function Summary:

UniProtKB/Swiss-Prot: XRN2_HUMAN, Q9H0D6

Function: Possesses 5'->3' exoribonuclease activity (By similarity). May promote the termination of transcription by

RNA polymerase II. During transcription termination, cleavage at the polyadenylation site liberates a 5' fragment

which is subsequently processed to form the mature mRNA and a 3' fragment which remains attached to the elongating

polymerase. The processive degradation of this 3' fragment by this protein may promote termination of transcription

Catalytic activity: Exonucleolytic cleavage in the 5'- to 3'-direction to yield nucleoside 5'-phosphates

Genatlas biochemistry entry for XRN2:

murine DHM1 gene homolog,5'-3' exoribonuclease 2,highly expressed in the testis,involved in homologous recomnbination

Enzyme Numbers (IUBMB): EC 3.1.13.-¹ EC 3.1.13²

miRNA Products:		OriGene 3'-UTR Clone: XRN2 Browse MicroRNA Expression Plasmids
		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat XRN2
		7 QIAGEN miScript miRNA Assays for microRNAs that regulate XRN2:
		hsa-miR-2052 hsa-miR-548am hsa-miR-548x hsa-miR-548c-3p hsa-miR-606 hsa-miR-3153 hsa-miR-3692
		SwitchGear 3'UTR luciferase reporter plasmid: XRN2 3' UTR sequence

Inhib. RNA Products:		Browse for Gene Knock-down Tools from EMD Millipore
		OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for XRN2 (see all 7) OriGene shRNA RFP: XRN2 OriGene siRNA: XRN2
		QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat XRN2

Gene Editing
Products:

DNA2.0 Custom Protein Engineering Service for XRN2

Clone Products:		Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
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		GenScript: all cDNA clones in your preferred vector: XRN2 (NM_012255)
		Browse Sino Biological Human cDNA Clones
		DNA2.0 Custom Codon Optimized Gene Synthesis Service for XRN2
		Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat XRN2

Cell Line Products:		GenScript Custom overexpressing Cell Line Services for XRN2
		Search LifeMap BioReagents cell lines for XRN2

In Situ Assay
Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for XRN2

Gene Ontology (GO): 5 molecular function terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0003676	nucleic acid binding	IEA	--
GO:0004518	nuclease activity	TAS	10409438
GO:0004534	5'-3' exoribonuclease activity	TAS	10409438
GO:0008270	zinc ion binding	IEA	--
GO:0008409	5'-3' exonuclease activity	IDA	15565158

XRN2 for ontologies About GeneDecksing

(Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to ¹UniProtKB, ²MINT, ³I2D, and/or ⁴STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
About This Section

Unified GeneCards pathways About this table

See pathways by source

Super-pathway

contained gene-specific pathways

Chaperonin-mediated protein folding

	Chaperonin-mediated protein folding	1.00			Association of TriC/CCT with target proteins during biosynthesis	0.60
	Protein folding	0.91

Ribosome biogenesis in eukaryotes

Ribosome biogenesis in eukaryotes

1.00

Deadenylation-dependent mRNA decay

RNA degradation

0.50

mRNA Splicing - Major Pathway

mRNA processing

0.48

Asparagine N-linked glycosylation

Metabolism of proteins

0.15

Pathway sources
See GeneCards unified pathways
Show all pathways

1 BioSystems Pathway for XRN2

mRNA processing

4 Reactome Pathways for XRN2

	Association of TriC/CCT with target proteins during biosynthesis
	Chaperonin-mediated protein folding
	Metabolism of proteins
	Protein folding

2 Kegg Pathways (Kegg details for XRN2):

	Ribosome biogenesis in eukaryotes
	RNA degradation

XRN2 for pathways About GeneDecksing

Interactions:

SABiosciences Gene Network Central^TM Interacting Genes and Proteins Network for XRN2

STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

5/806 Interacting proteins for XRN2 (Q9H0D6^{2, 3} ENSP00000366396⁴) via UniProtKB, MINT, STRING, and/or I2D (see all 806)

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
UPF2	Q9HAU5²^,³, ENSP00000348708⁴	MINT-7945693 MINT-7947479 I2D: score=4 STRING: ENSP00000348708
EEF1A1	P68104²^,³, ENSP00000330054⁴	MINT-7945693 MINT-7947479 I2D: score=3 STRING: ENSP00000330054
EIF3L	Q9Y262²^,³, ENSP00000416892⁴	MINT-7945693 I2D: score=3 STRING: ENSP00000416892
TARDBP	Q13148²^,³, ENSP00000240185⁴	MINT-7945693 MINT-7947479 I2D: score=4 STRING: ENSP00000240185
EXOSC10	Q01780²^,³, ENSP00000366135⁴	MINT-7945693 MINT-7947479 I2D: score=4 STRING: ENSP00000366135

About this table

Gene Ontology (GO): 5/10 biological process terms (GO ID links to tree view) (see all 10): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0000738	DNA catabolic process, exonucleolytic	IDA	15565158
GO:0006353	DNA-dependent transcription, termination	IEA	--
GO:0006355	regulation of transcription, DNA-dependent	IEA	--
GO:0006396	RNA processing	TAS	10409438
GO:0006397	mRNA processing	IEA	--

XRN2 for ontologies About GeneDecksing

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
About This Section

Browse Small Molecules at EMD Millipore

Browse drugs & compounds from Enzo Life Sciences

Browse Tocris compounds for XRN2
Search CenterWatch for drugs/clinical trials and news about XRN2

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from EMD Millipore,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
About This Section

REFSEQ mRNAs for XRN2 gene:

NM_012255.3

Unigene Cluster for XRN2:

5'-3' exoribonuclease 2

Hs.255932 [show with all ESTs]

Unigene Representative Sequence: BC142960

3 Ensembl transcripts including schematic representations, and UCSC links where relevant:

ENST00000377191(uc002wsf.1 uc002wsg.1) ENST00000539513(uc010zsk.1 uc002wsh.1)

ENST00000430571

miRNA Products:		OriGene 3'-UTR Clone: XRN2 Browse OriGene MicroRNA Expression Plasmids
		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat XRN2
		7 QIAGEN miScript miRNA Assays for microRNAs that regulate XRN2:
		hsa-miR-2052 hsa-miR-548am hsa-miR-548x hsa-miR-548c-3p hsa-miR-606 hsa-miR-3153 hsa-miR-3692
		SwitchGear 3'UTR luciferase reporter plasmid: XRN2 3' UTR sequence

Inhib. RNA Products:		Browse for Gene Knock-down Tools from EMD Millipore
		OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for XRN2 (see all 7) OriGene shRNA RFP: XRN2 OriGene siRNA: XRN2
		QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat XRN2

Clone Products:		OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for XRN2 (see all 4) OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for XRN2 OriGene custom cloning services � gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
		GenScript: all cDNA clones in your preferred vector: XRN2 (NM_012255)
		DNA2.0 Custom Codon Optimized Gene Synthesis Service for XRN2
		Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat XRN2

Primer Products:		OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for XRN2 Browse OriGene validated miRNA SYBR primer pairs
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		QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat XRN2
		QIAGEN QuantiFast Probe-based Assays in human, mouse, rat XRN2

Additional cDNA sequence:

AF064257.1 AF152169.1 AK000084.1 AK001573.1 AK172858.1 AK302846.1 AK303312.1 AK314602.1

AL136841.1 AY382900.1 BC000315.2 BC006417.1 BC032075.2 BC131775.1 BC142960.1

24 DOTS entries:

DT.101976662 DT.416242 DT.102832941 DT.97847492 DT.439293 DT.100808866 DT.92062355 DT.75101626

DT.75168600 DT.100810382 DT.91805915 DT.91858750 DT.92409492 DT.95185286 DT.95221799 DT.100810389

DT.102832940 DT.102832943 DT.120807525 DT.95218276 DT.95221798 DT.95221814 DT.99961805 DT.99982457

24/379 AceView cDNA sequences (see all 379):

AA314456 CB141497 AW242471 AW250130 AI372022 AW196349 BM451916 AI796426

BU620774 BX953011 BX383411 BU176486 BM729186 BU929425 BM765990 BX102929

AK000084 BE551504 BM783374 BQ226591 BM823036 AU125088 BQ644805 BQ440589

GeneLoc Exon Structure

5/7 Alternative Splicing Database (ASD) splice patterns (SP) for XRN2 (see all 7) About this scheme

ExUns:	1a	·	1b	·	1c	·	1d	^	2	^	3	^	4	^	5a	·	5b	^	6	^	7a	·	7b	^	8	^	9	^	10	^	11	^	12	^	13	^	14	^	15a	·	15b	^	16	^	17a	·	17b	^	18	^	19	^
SP1:									-								-																														-
SP2:									-		-						-																														-
SP3:																	-
SP4:									-		-		-		-		-		-		-		-		-		-		-		-		-		-		-		-		-		-		-		-		-		-
SP5:									-

ExUns:	20	^	21	^	22	^	23a	·	23b	^	24	^	25	^	26	^	27	^	28	^	29	^	30	^	31a	·	31b
SP1:									-
SP2:									-
SP3:
SP4:	-		-		-		-		-		-		-		-		-		-
SP5:

ECgene alternative splicing isoforms for XRN2

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section

XRN2 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: CTGATTTTTA

About this image
See XRN2 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for XRN2

SOURCE GeneReport for Unigene cluster: Hs.255932

UniProtKB/Swiss-Prot: XRN2_HUMAN, Q9H0D6

Tissue specificity: Expressed in the spleen, thymus, prostate, testis, ovary, small intestine, colon, peripheral blood

leukocytes, heart, brain, placenta, lung, liver, skeletal muscle, kidney, and pancreas. Isoform 2 is expressed

predominantly in peripheral blood leukocytes

SABiosciences Custom PCR Arrays for XRN2

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		QIAGEN QuantiFast Probe-based Assays in human, mouse, rat XRN2

In Situ
Assay Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for XRN2

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD , ⁵MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or ⁶Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
About This Section

This gene was present in the common ancestor of eukaryotes.

Orthologs for XRN2 gene from 10/34 species (see all 34) About this table

Organism	Taxonomic classification	Gene	Description	Human Similarity	Orthology Type	Details
mouse (Mus musculus)	Mammalia	Xrn2^{1 , 5}	5'-3' exoribonuclease 2^{1, 5}	92.35(n)¹ 96.11(a)¹		2 (72.63 cM)⁵ 24128¹ NM_011917.2¹ NP_036047.2¹ 147012996⁵
chicken (Gallus gallus)	Aves	XRN2¹	5'-3' exoribonuclease 2	78.92(n) 83.47(a)		421236 NM_001031033.1 NP_001026204.1
lizard (Anolis carolinensis)	Reptilia	XRN2⁶	--	79(a)	1 ↔ 1	4(81316733-81369927)
tropical clawed frog (Xenopus tropicalis)	Amphibia	Str.1210²	Transcribed sequence with moderate similarity to protein pirI49635 (M.musculus) I49635 mouse Dhm1 protein - mouse less	81.61(n)		142003644
zebrafish (Danio rerio)	Actinopterygii	idibd1090²	Danio rerio mRNA similar to 5'-3' exoribonuclease 2 (cDNA clone MGC55717 IMAGE3816008), complete cds less	74.74(n)		BC047182.1
fruit fly (Drosophila melanogaster)	Insecta	CG10354³ Rat1¹	5'-3' exoribonuclease³ CG10354-PA¹	44(a) (best of 2)³ 56.89(n)¹ 60.2(a)¹		27C4³ 33964¹ NM_135238.2¹ NP_609082.1¹
worm (Caenorhabditis elegans)	Secernentea	Y48B6A.3³ xrn-2¹	Protein XRN-2¹	54(a) (best of 2)³ 57.75(n)¹ 58.52(a)¹		II(14155604-14158131)³ 175071¹ NM_064557.4¹ NP_496958.2¹
baker's yeast (Saccharomyces cerevisiae)	Saccharomycetes	RAT1(YOR048C)⁴ RAT1¹	Nuclear 5' to 3' single-stranded RNA exonuclease, involved in RNA metabolism, including rRNA and snRNA processing as well as poly (A+) dependent and independent mRNA transcription termination less⁴ Rat1p¹	53.12(n)¹ 47.45(a)¹		15(421650-418630)⁴ 854213^{1, 4} NP_014691.1^{1, 4}
thale cress (Arabidopsis thaliana)	eudicotyledons	XRN3¹	5'-3' exoribonuclease 3	53.99(n) 48(a)		843900 NM_106217.2 NP_565114.1
rice (Oryza sativa)	Liliopsida	Os.19368²	Oryza sativa (japonica cultivar-group) cDNA cloneJ023064E05, full insert sequence less	73.93(n)		AK070933.1

ENSEMBL Gene Tree for XRN2 (if available)
TreeFam Gene Tree for XRN2 (if available)

(Paralogs according to ¹HomoloGene,
²Ensembl, and ³SIMAP, Pseudogenes according to ⁴Pseudogene.org Build 68)
About This Section

(SNPs/Variants according to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section

SNP ID	Valid	Clinical significance	Chr 20 pos	Sequence	#	AA Chg	Type	More	#	Allele freq	Pop	Total sample	More
Genomic Data					Transcription Related Data				Allele Frequencies
				--	--	--		--	--
rs3761287^1,2	C,F,	--	21281988(+)	`GAATCG/ACTTGA`	1	--	us2k¹		6		NA WA	12
rs184554732^1,2		--	21282213(+)	`TCTTAC/TCTTTT`	1	--	us2k¹		0	--	--	--	--
rs145544290^1,2		--	21282226(+)	`CGTTCA/GCGCAC`	1	--	us2k¹		0	--	--	--	--
rs189249602^1,2		--	21282423(+)	`ATCAGC/TGGGGT`	1	--	us2k¹		0	--	--	--	--
rs3761288^1,2	C,F,A,H,	--	21282545(+)	`CCTGGA/GTGACT`	1	--	us2k¹		7		NA WA EA	370
rs148854769^1,2		--	21282880(+)	`CTGTGA/CGGTAA`	1	--	us2k¹		0	--	--	--	--
rs34459185^1,2	C,F,	--	21282895(+)	`GCGAAA/CTACTT`	1	--	us2k¹		1		NA	120
rs181216745^1,2		--	21282920(+)	`TGAGGA/TGAGCA`	1	--	us2k¹		0	--	--	--	--
rs145324789^1,2		--	21283044(+)	`AAATTA/CGTTTG`	1	--	us2k¹		0	--	--	--	--
rs146433514^1,2		--	21283051(+)	`TTTGGA/GACCAC`	1	--	us2k¹		0	--	--	--	--

HapMap Linkage Disequilibrium report for XRN2 (21283942 - 21370463 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 10 variations for XRN2
8 CNVs: 90503 79148 44043 39288 23622 102933 67669 61918
2 Indels: 12168 79149

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(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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XRN2 for disorders           About GeneDecksing

OMIM gene information: 608851    OMIM disorders: --

5 diseases for XRN2:    About MalaCards

pharyngitis schizophrenia malaria prostatitis

neuronitis

Export disorders for XRN2 gene to outside databases

(in PubMed. Associations of this gene to articles via ¹Entrez Gene, ²UniProtKB/Swiss-Prot, ³HGNC, ⁴GAD, ⁵PharmGKB, ⁶HMDB, ⁷DrugBank, ⁸UniProtKB/TrEMBL, ⁹ Novoseek, and/or ¹⁰fRNAdb)
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PubMed articles for XRN2 gene, integrated from 9 sources (see all 47):
(articles sorted by number of sources associating them with XRN2)

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world of online information

Cloning and mapping of the XRN2 gene to human chromosome 20p11.1- p11.2. (PubMed id 10409438)^{1, 2, 3, 9} Zhang M.... Zhao S.Y. (1999)
A novel splice variant of human XRN2 gene is mainly expressed in blood leukocyte. (PubMed id 16147866)^{1, 2, 9} Li J.... Mao Y. (2005)
A probability-based approach for high-throughput protein phosphorylation analysis and site localization. (PubMed id 16964243)^{1, 2} Beausoleil S.A.... Gygi S.P. (2006)
Pause sites promote transcriptional termination of mammalian RNA polymerase II. (PubMed id 16648491)^{1, 2} Gromak N.... Proudfoot N.J. (2006)
Global, in vivo, and site-specific phosphorylation dynamics in signaling networks. (PubMed id 17081983)^{1, 2} Olsen J.V....Mann M. (2006)
Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)^{1, 2} Ota T.... Sugano S. (2004)
Human 5' -> 3' exonuclease Xrn2 promotes transcription termination at co-transcriptional cleavage sites. (PubMed id 15565158)^{1, 2} West S.... Proudfoot N.J. (2004)
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)^{1, 2} Gerhard D.S....Malek J. (2004)
Functional proteomic analysis of human nucleolus. (PubMed id 12429849)^{1, 2} Scherl A.... Diaz J.-J. (2002)
The DNA sequence and comparative analysis of human chromosome 20. (PubMed id 11780052)^{1, 2} Deloukas P....Rogers J. (2001)

(in PubMed, OMIM, and NCBI Bookshelf)
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		AND	OR
Aliases
Free Text

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(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
About This Section

Entrez Gene: 22803	HGNC: 12836	AceView: XRN2	Ensembl:ENSG00000088930	euGenes: HUgn22803
ECgene: XRN2	Kegg: 22803	H-InvDB: XRN2

(According to HUGE)
About This Section

(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section

Name	Description
PharmGKB entry for XRN2	Pharmacogenomics, SNPs, Pathways
ATLAS Chromosomes in Cancer entry for XRN2	Genetics and Cytogenetics in Oncology and Haematology

Intellectual Property for XRN2 gene
(Patent information from GeneIP, Licensable technologies from WIS Yeda, Salk, Tufts, IP news from LifeMap Sciences, Inc.)

About This Section

Patent Information for XRN2 gene:
Search GeneIP for patents involving XRN2

GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search

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