V3 here soon-try beta now


Gene Search (GeneCards Home)	\|	GeneCards Guide	\|	User Feedback	\|	Terms of Use	\|	Notice about third-party sites

XRN2 Gene

protein-coding GIFtS: 60

GC20P021231

5'-3' exoribonuclease 2
Symbol approved by the HUGO Gene Nomenclature Committee (HGNC) database

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc , and/or ⁷Ensembl, ⁸miRBase)
About This Section

Aliases
EC 3.1.13.- ^³
OTTHUMP00000030403 ^²

Descriptions
5'-3' exoribonuclease 2 ^²
DHM1-like protein ^³
DHP protein ^³
Dhm1-like protein (mouse homolog) ^²

External Ids
HGNC: 12836¹
Entrez Gene: 22803²
UniProtKB: Q9H0D6³
Ensembl: ENSG00000088930⁷

Search outside databases for aliases for XRN2 gene

Previous GC identifers: GC20P021272 GC20P021278

(According to Entrez Gene, Wikipedia's Gene Wiki,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

EntrezGene summary for XRN2:

This gene shares similarity with the mouse Dhm1 and the yeast dhp1 gene. The yeast gene is involved

in homologous recombination and RNA metabolism, such as RNA synthesis and RNA trafficking.

Complementation studies show that Dhm1 has a similar function in mouse as dhp1. The function of

the human gene has not yet been determined. Transcript variants encoding different isoforms have

been noted for this gene; however, their full-length nature is not known. [provided by RefSeq]

UniProtKB/Swiss-Prot: XRN2_HUMAN, Q9H0D6

Function: Possesses 5'->3' exoribonuclease activity (By similarity). May promote the termination of

transcription by RNA polymerase II. During transcription termination, cleavage at the

polyadenylation site liberates a 5' fragment which is subsequently processed to form the mature

mRNA and a 3' fragment which remains attached to the elongating polymerase. The processive

degradation of this 3' fragment by this protein may promote termination of transcription

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 36),
and/or miRBase,
Genomic Views according to UCSC and Ensembl, Transcription factor binding sites according to SABiosciences)
About This Section

Genomic View:

UCSC Golden Path with GeneCards custom track

Transcription factor binding sites upstream to the XRN2 gene

Entrez Gene cytogenetic band: 20p11.2-p11.1 Ensembl cytogenetic band: 20p11.22 HGNC cytogenetic band: 20p11.2-p11.1

XRN2 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)

GeneLoc gene densities for chromosome 20 GeneLoc Exon Structure

GeneLoc location for GC20P021231: (about GC identifiers)

Start:	21,231,922 bp from pter
End:	21,318,463 bp from pter
Size:	86,542 bases
Orientation:	plus strand

RefSeq DNA sequence:

NC_000020.9 NT_011387.8

(According to ¹UniProtKB, and/or Ensembl, Phosphorylation sites according to ²Phosphosite, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Enzo Life Sciences, Abnova, OriGene and/or, Abcam,
Biochemical Assays by Invitrogen, Millipore, R&D Systems, Cell Signaling Technology, and/or Enzo Life Sciences, Ontologies according to Gene Ontology Consortium 01 Apr 2009 and Entrez Gene, Antibodies by Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Cell Signaling Technology, Abcam, Abnova, and/or Novus Biologicals)
About This Section

UniProtKB/Swiss-Prot: XRN2_HUMAN, Q9H0D6 (See protein sequence)

Recommended Name: 5'-3' exoribonuclease 2

Size: 950 amino acids; 108582 Da

Subcellular location: Nucleus, nucleolus

Sequence caution: Sequence=AAR24369.1; Type=Frameshift; Positions=73;

Secondary accessions: Q3L8N4 Q6KGZ9 Q9BQL1 Q9NTW0 Q9NXS6 Q9UL53

Alternative splicing: 2 isoforms: Q9H0D6-1 Q9H0D6-2

Post-translational modifications:

View phosphorylation sites using PhosphoSite²

REFSEQ proteins: NP_036387.2

ENSEMBL proteins:

ENSP00000366396

Human Recombinant Proteins

	Browse Drug Discovery Central at Invitrogen for human recombinant proteins
	Browse Purified and Recombinant Proteins at Millipore
	Browse Human Recombinant Proteins at Sigma-Aldrich
	Browse R&D Systems for human recombinant proteins
	Browse recombinant and purified proteins available from Enzo Life Sciences
	Recombinant Proteins from Abcam (XRN2)
	Human Recombinant Proteins from Abnova (XRN2)

Browse Origene for full length recombinant human proteins expressed in human HEK293 cells

3 Gene Ontology (GO) cellular component terms (links to tree view):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005622	intracellular	IEA	--
GO:0005634	nucleus	TAS	10409438
GO:0005730	nucleolus	IDA	12429849

About this table

Antibodies for XRN2:

	Browse Antibodies Central at Invitrogen
	Browse Millipore's Extensive Line of Mono- and Polyclonal Antibodies
	Browse Antibodies at Sigma-Aldrich
	Browse R&D Systems for Antibodies
	Antibodies from Abcam (XRN2), each with their Abpromise^SM
	Browse Abnova for Monoclonal and Polyclonal Antibodies
	Novus Biologicals Antibodies for XRN2

Assays for XRN2:

	Browse Invitrogen for biochemical assays
	Browse Kits and Assays available from Millipore
	Browse R&D Systems for biochemical assays
	Browse biochemical assays available from Enzo Life Sciences

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

Graphical View of Domain Structure for InterPro Entry Q9H0D6

ProtoNet protein and cluster: Q9H0D6

2 Blocks protein families:

IPB001878 C2HC-type zinc-finger signature

IPB004859 Putative 5-3 exonuclease domain

UniProtKB/Swiss-Prot: XRN2_HUMAN, Q9H0D6

Similarity: Belongs to the 5'-3' exonuclease family. XRN2/RAT1 subfamily

Similarity: Contains 1 CCHC-type zinc finger

(According to MGI Jun 06 2009, UniProtKB, IUBMB,and/or Genatlas,
shRNA from OriGene, Sigma-Aldrich, RNAi from Sigma-Aldrich,
RNAi Products, Clones, and Q-PCR Products from Invitrogen, Millipore, OriGene, and/or Abnova, siRNAs from Applied Biosystems, SYBR primers from OriGene, Cell-based Assays from Millipore, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
About This Section

Inhib. RNA:		Invitrogen RNAi Products for gene knock-down (XRN2)
		Browse for Gene Knock-down Tools from Millipore
		Abnova Chimera RNAi Products for Gene knock-down (XRN2)

OriGene 29mer shRNA kit in GFP-retroviral vector: NM_012255

Applied Biosystems Silencer® siRNAs for XRN2

Sigma-Aldrich siRNA for XRN2

Sigma-Aldrich shRNA Panels and shRNA for XRN2

Explore Sigma-Aldrich super-pooled esiRNAs

Clones:		Browse Clone Ranger at Invitrogen for clones
		Browse Clones for the Expression of Recombinant Proteins Available from Millipore

OriGene GFP tagged cDNA clone in CMV expression vector: NM_012255
Myc/DDK tagged cDNA clone in CMV expression vector: NM_012255
untagged cDNA clone in CMV expression vector: NM_012255

Primers:

Browse Quantitative PCR Central at Invitrogen for Q-PCR LUX™ Primers

OriGene genome-wide validated SYBR primer pairs: NM_012255

UniProtKB/Swiss-Prot: XRN2_HUMAN, Q9H0D6

Function: Possesses 5'->3' exoribonuclease activity (By similarity). May promote the termination of

transcription by RNA polymerase II. During transcription termination, cleavage at the

polyadenylation site liberates a 5' fragment which is subsequently processed to form the mature

mRNA and a 3' fragment which remains attached to the elongating polymerase. The processive

degradation of this 3' fragment by this protein may promote termination of transcription

Catalytic activity: Exonucleolytic cleavage in the 5'- to 3'-direction to yield nucleoside

5'-phosphates

Enzyme Number (IUBMB): EC 3.1.13.-

Genatlas biochemistry entry for XRN2:

murine DHM1 gene homolog,5'-3' exoribonuclease 2,highly expressed in the testis,involved in

homologous recomnbination

5/6 Gene Ontology (GO) molecular function terms (links to tree view) (see all 6 ):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0003676	nucleic acid binding	IEA	--
GO:0004534	5'-3' exoribonuclease activity	TAS	10409438
GO:0005515	protein binding	IPI	15231747
GO:0008270	zinc ion binding	IEA	--
GO:0016787	hydrolase activity	IEA	--

About this table

(Pathways according to Invitrogen (maps by GeneGo), Millipore, Cell Signaling Technology, Sigma-Aldrich, KEGG and/or UniProtKB,
Sets of similar genes according to GeneDecks, Proteins Network according to SABiosciences, Interactions according to ¹UniProtKB, ²MINT, and/or ³STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
About This Section

Gene Network Central^TM Interacting Genes and Proteins Network for XRN2

5/16 Interacting proteins for XRN2 (Q9H0D6^{1, 2} ENSP00000366396³) via UniProtKB, MINT, and/or STRING (see all 16 )

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
COMT	P21964¹	EBI-372110, EBI-372265
DOM3Z	O77932¹	EBI-372110, EBI-372173
EIF3L	Q9Y262¹	EBI-372110, EBI-373519
EIF5A	P63241¹	EBI-372110, EBI-373150
EIF6	P56537¹	EBI-372110, EBI-372243

About this table

5/8 Gene Ontology (GO) biological process terms (links to tree view) (see all 8 ):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0000738	DNA catabolic process, exonucleolytic	IDA	15565158
GO:0006350	transcription	IEA	--
GO:0006353	transcription termination	IEA	--
GO:0006355	regulation of transcription, DNA-dependent	IEA	--
GO:0006397	mRNA processing	IEA	--

About this table

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, Sigma-Aldrich, Tocris Bioscience, and/or Novoseek and Drugs according to Enzo Life Sciences and/or PharmGKB)
About This Section

Browse drugs & compounds from Enzo Life Sciences

Browse Small Molecules at Sigma-Aldrich

Browse Tocris compounds for XRN2

(GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 219 Homo sapiens; Jun 2 2009) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView,
non coding RNAs according to RNAdb,
ESTs according to GeneTide,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from Invitrogen, Millipore, and/or Abnova,
siRNAs from Applied Biosystems, Sigma-Aldrich,
shRNA from Sigma-Aldrich, OriGene,
Tagged/untagged cDNA clones from OriGene,
Expression Assays from Applied Biosystems)
About This Section

Inhib. RNA:		Invitrogen RNAi Products for gene knock-down (XRN2)
		Browse for Gene Knock-down Tools from Millipore
		Abnova Chimera RNAi Products for Gene knock-down (XRN2)

OriGene 29mer shRNA kit in GFP-retroviral vector: NM_012255

Sigma-Aldrich siRNA for XRN2

Sigma-Aldrich shRNA Panels and shRNA for XRN2

Explore Sigma-Aldrich super-pooled esiRNAs

Applied Biosystems Silencer® siRNAs:

NM_012255

REFSEQ mRNAs for XRN2 gene:

NM_012255.3

Applied Biosystems TaqMan ® Gene Expression Assays:

NM_012255

              OriGene GFP tagged cDNA clone in CMV expression vector: NM_012255
                                 Myc/DDK tagged cDNA clone in CMV expression vector: NM_012255
                                 untagged cDNA clone in CMV expression vector: NM_012255

Additional cDNA sequence:

AF064257.1 AF152169.1 AK000084.1 AK001573.1 AK172858.1 AK302846.1 AK303312.1 AK314602.1

AL136841.1 AY382900.1 BC000315.2 BC006417.1 BC032075.2 BC131775.1 BC142960.1 CR602097.1

CR607652.1

24 DOTS entries:

DT.101976662 DT.416242 DT.102832941 DT.97847492 DT.439293 DT.75168600 DT.100808866 DT.91858750

DT.92062355 DT.99961805 DT.75101626 DT.100810382 DT.91805915 DT.92409492 DT.95185286 DT.95221799

DT.100810389 DT.102832940 DT.102832943 DT.120807525 DT.95218276 DT.95221814 DT.95221798 DT.99982457

24/379 AceView cDNA sequences (see all 379 ):

AI796426 AW242471 AU133886 BM729186 BU620774 BC000315 BF219758 BX102929

BQ936061 CR602097 AL136841 AA354795 BM554664 BM263312 BM451916 AA323017

BG912059 BM719870 BQ440589 BQ644805 H96017 BX953011 AU125088 BU181047

highest scoring ESTs for XRN2:

AA035728 AA028164 AA149978 AA173571 AA194725 AA195566 AA292791 AA418041 AA418212 AA426479

Unigene Cluster for XRN2:

5'-3' exoribonuclease 2

Hs.255932 [show with all ESTs]

Unigene Representative Sequence: BC142960

GeneLoc Exon Structure

5/7 Alternative Splicing Database (ASD) splice patterns (SP) for XRN2 (see all 7 )

ExUns:	1a	·	1b	·	1c	·	1d	^	2	^	3	^	4	^	5a	·	5b	^	6	^	7a	·	7b	^	8	^	9	^	10	^	11	^	12	^	13	^	14	^	15a	·	15b	^	16	^	17a	·	17b	^	18	^	19	^
SP1:									-								-																														-
SP2:									-		-						-																														-
SP3:																	-
SP4:									-		-		-		-		-		-		-		-		-		-		-		-		-		-		-		-		-		-		-		-		-		-
SP5:									-

ExUns:	20	^	21	^	22	^	23a	·	23b	^	24	^	25	^	26	^	27	^	28	^	29	^	30	^	31a	·	31b
SP1:									-
SP2:									-
SP3:
SP4:	-		-		-		-		-		-		-		-		-		-
SP5:

About this scheme

ECgene alternative splicing isoforms for XRN2

1 Ensembl transcript including schematic representation:

ENST00000377191

(Experimental results according to ¹GeneNote and GNF BioGPS,
probe sets-to-genes annotations according to ²GeneAnnot , ³GeneTide , Sets of similar genes according to GeneDecks, Electronic Northern calculations according to data from UniGene (Build 219 Homo sapiens), SAGE tags according to CGAP, plus additional links to SOURCE, and/or GNF BioGPS, and/or EXPOLDB, and/or UniProtKB,
Expression Assays from Applied Biosystems )
About This Section

XRN2 expression in normal and diseased human tissues

Applied Biosystems TaqMan ® Gene Expression Assays for XRN2

¹ / ² / ³

7 probe-sets matching XRN2 gene

Affymetrix probe-set	Array	# genes	Sensitivity	Specificity	Correlation	Length	Gb_Accession	Consensus	Uniqueness	Score	Rank
Affymetrix probe-set	Array	GeneAnnot data			GeneNote data		GeneTide data
45825_at²^{, 3}	U95-B	1	1.00	1.00	0.86	0.99	AA035728	1.00	1.00	1.00	1
77664_at²^{, 3}	U95-E	1	1.00	1.00	0.91	0.85	AA173571	0.80	1.00	0.91	1
80109_at²^{, 3}	U95-E	1	0.81	1.00	0.82	1.16	AI797508	0.40	1.00	0.76	1
233878_s_at²^{, 3}	U133-B	1	1.00	1.00	--	--	BE536170	0.60	1.00	0.82	1
223002_s_at²^{, 3}	U133-B	1	1.00	1.00	--	--	AL136841	0.80	1.00	0.91	1
233878_s_at²	U133Plus2	1	1.00	1.00	--	--	--	--	--	--	--
223002_s_at²	U133Plus2	1	1.00	1.00	--	--	--	--	--	--	--

GeneDecks XRN2 for binary patterns associated with the probe-sets selected above

About GeneDecksing

About this table

Data from

(Publications) and GNF BioGPS
About these images
About these images

CGAP SAGE TAG: CTGATTTTTA

SOURCE GeneReport for Unigene cluster: Hs.255932
UniProtKB/Swiss-Prot: XRN2_HUMAN, Q9H0D6
Tissue specificity: Expressed in the spleen, thymus, prostate, testis, ovary, small intestine,
colon, peripheral blood leukocytes, heart, brain, placenta, lung, liver, skeletal muscle, kidney,
and pancreas. Isoform 2 is expressed predominantly in peripheral blood leukocytes

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD and/or ⁵MGI Jun 06 2009, with possible further links to Flybase and/or WormBase, Gene Trees according to Ensembl)
About This Section

Orthologs for XRN2 gene from 5/22 species (see all 22 )

Organism	Gene	Locus	Description	Human Similarity	NCBI accessions
dog (Canis familiaris)	XRN2¹	--	5'-3' exoribonuclease 2	94.07(n) 97.26(a)	477133 XM_850895.1 XP_855988.1
chimpanzee (Pan troglodytes)	XRN2¹	--	5'-3' exoribonuclease 2	99.79(n) 99.79(a)	458131 XM_514546.2 XP_514546.2
cow (Bos taurus)	XRN2¹	--	5'-3' exoribonuclease 2	91.93(n) 95.89(a)	517417 XM_595586.3 XP_595586.3
rat (Rattus norvegicus)	Xrn2¹	--	5'-3' exoribonuclease 2	91.72(n) 96.84(a)	362229 XM_342535.3 XP_342536.3
mouse (Mus musculus)	Xrn2^{1, 5}	2⁵	5'-3' exoribonuclease 2^{1, 5}	92.35(n)¹ 96.11(a)¹	24128¹ NM_011917.2¹ NP_036047.2¹ AA472293⁵ AK004800⁵ (see all 24)

About this table Species with no ortholog for XRN2

ENSEMBL Gene Tree for XRN2

(Paralogs according to ¹HomoloGene
and ²Ensembl, Pseudogenes according to ³Pseudogene.org)
About This Section

Paralogs for XRN2 gene

XRN1²

(According to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, and UniProtKB, Linkage Disequilibrium by HapMap, Genotyping Reagents from Applied Biosystems)
About This Section

10/478 NCBI SNPs in XRN2 are shown (see all 478 )
(Click for Applied Biosystems TaqMan ® Genotyping Assay) (see all 149)

AB	SNP ID	Valid	Chr 20 pos	Sequence	Recs	AA Chg	Type	More	Recs	Allele freq	Pop	Total sample	More
AB	Genomic Data				Transcription Data				Allele Frequencies
				--	--	--		--	--				--
	rs3761289^1,2	A,C,F,H	21231096(+)	`AAGGAC/TGGATT`	1	--	ng5¹ tfbs³		8		EU EA WA	838
	rs3761290^1,2	A,C,F,H	21231435(+)	`TTATTA/GCTGTA`	1	--	ng5¹		6		EU EA WA MN	1670
--	rs3761288^1,2	A,C	21230545(+)	`cctggA/Gtgact`	1	--	ng5¹		0	--	--	--	--
--	rs6137317^1,2	C,H	21259291(+)	`CCTTCG/ACTATT`	1	H/R	mis¹		4		EU EA WA	404
--	rs6047420^1,2	C,H	21315630(+)	`ATGATC/TGTGGA`	1	R/C	mis¹		4		EU EA WA	406
--	rs3761287^1,2	C	21229988(+)	`GAATCA/GCTTGA`	1	--	ng5¹		0	--	--	--	--
--	rs11471969^1,2	F	21318334(+)	`AACTCTT/-GAGCT`	1	--	ut3¹		5		EU EA NA MN	430
	rs6137324^1,2	H	21286403(+)	`GTTAAG/AGGATC`	1	K/R	mis¹		4		EU EA WA	420
	rs6113198^1,2	H	21269463(+)	`GCAGCC/TTATGA`	1	A/A	syn¹ ese³		4		EU EA WA	420
	rs6113197^1,2	H	21269406(+)	`CATGCC/TTTGGG`	1	A/A	syn¹		4		EU EA WA	420

About this table

HapMap Linkage Disequilibrium images for XRN2 (up to first 250kb)

(in which this Gene is Involved, According to OMIM, UniProtKB, PharmGKB, Genatlas, GeneTests, Blood group antigen gene mutations by BGMUT, HGMD, GAD, HuGE Navigator, BCGD, and/or TGDB.)
About This Section

OMIM: 608851

(Possibly Related Articles in Doctor's Guide)
About This Section

(in PubMed. Associations of this gene to articles via ¹Novoseek, ²HGNC, ³Entrez Gene, ⁴UniProtKB/Swiss-Prot, ⁵UniProtKB/TrEMBL, ⁶GAD, and/or ⁷PharmGKB)
About This Section

10/23 PubMed articles for XRN2 gene (see all 23 ):

Cloning and mapping of the XRN2 gene to human chromosome 20p11.1- p11.2. (PubMed id 10409438)^{1, 2, 3, 4} Zhang M.... Zhao S.Y. (1999)
A novel splice variant of human XRN2 gene is mainly expressed in blood leukocyte. (PubMed id 16147866)^{1, 3, 4} Li J.... Mao Y. (2005)
A probability-based approach for high-throughput protein phosphorylation analysis and site localization. (PubMed id 16964243)^{3, 4} Beausoleil S.A.... Gygi S.P. (2006)
Global, in vivo, and site-specific phosphorylation dynamics in signaling networks. (PubMed id 17081983)^{3, 4} Olsen J.V....Mann M. (2006)
Pause sites promote transcriptional termination of mammalian RNA polymerase II. (PubMed id 16648491)^{3, 4} Gromak N.... Proudfoot N.J. (2006)
Human 5' -> 3' exonuclease Xrn2 promotes transcription termination at co-transcriptional cleavage sites. (PubMed id 15565158)^{3, 4} West S.... Proudfoot N.J. (2004)
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)^{3, 4} Gerhard D.S....Malek J. (2004)
Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)^{3, 4} Ota T....Sugano S. (2004)
Large-scale characterization of HeLa cell nuclear phosphoproteins. (PubMed id 15302935)^{3, 4} Beausoleil S.A....Gygi S.P. (2004)
Functional proteomic analysis of human nucleolus. (PubMed id 12429849)^{3, 4} Scherl A.... Diaz J.-J. (2002)

(in PubMed, OMIM, and NCBI Bookshelf)
About This Section

		AND	OR
Aliases
Free Text

Query String		PubMed OMIM NCBI Bookshelf
	(Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, and/or H-InvDB)
About This Section

Entrez Gene: 22803	HGNC: 12836	AceView: XRN2	Ensembl:ENSG00000088930	euGenes: HUgn22803
ECgene: XRN2	H-InvDB: XRN2

(According to HUGE)
About This Section

(According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section

Name	Description
ATLAS Chromosomes in Cancer entry for XRN2	Genetics and Cytogenetics in Oncology and Haematology

Licensable Technologies for XRN2
(Available from WIS Yeda, Salk, Tufts)

About This Section

(Reagents available from Applied Biosystems, Antibodies and assays by Cell Signaling Technology, Abcam, Novus Biologicals,
Sigma-Aldrich, R&D Systems, Millipore, Abnova, and/or Invitrogen, Clones available from OriGene,and/or Invitrogen, Drugs and/or compounds by Sigma-Aldrich,
Enzo Life Sciences, and/or Tocris Bioscience)
About This Section

Products for XRN2:

TaqMan ® Gene Expression Assays

TaqMan ® Genotyping Assays

Free SNP selection tool

Invitrogen iPath Pathways	Invitrogen BLOCK-iT™ RNAi
Invitrogen Antibodies	Invitrogen Assays
Invitrogen Clones	Invitrogen Q-PCR Products
Invitrogen Human Recombinant Kinases	Invitrogen Custom Antibody and Peptide Service
Invitrogen Proteins / Assays / Screening Services	Search Invitrogen catalog for XRN2-related products

	Millipore Custom Antibody & Bulk Services
	Millipore Preclinical / Clinical Development Services
	Millipore Immunoassay Services
	Millipore Target Screening & Profiling Services

	Predesigned and custom siRNAs for XRN2		Browse antibodies at Sigma-Aldrich
	Explore super-pooled esiRNAs		Browse proteins at Sigma-Aldrich
	Lentivirus-delivered shRNAs for XRN2		Browse small molecules at Sigma-Aldrich
	"Your Favorite Gene" Pathways		feedback

	Antibodies		Primer Pairs
	Cell Culture Products		ELISAs
	Flow Cytometry Kits		Protease Activity Assays & Reagents
	Cell Selection/Detection Kits & Reagents		ELISA/Assay Development Kits & Reagents
	Multiplex/Array Assay Kits & Reagents		ELISpot Kits & Development Modules
	Recombinant & Natural Proteins

	Recombinant Proteins (XRN2)
	Search for Antibodies
	Chimera RNAi (XRN2)
	Custom Service for Mouse Mab
	Custom Service for Rabbit Pab from Full-length Protein

Search for Antibodies & Assays

	Recombinant Proteins (XRN2)
	Antibodies (XRN2)

Search OriGene for XRN2

Search Tocris compounds for XRN2

Search www.enzolifesicences.com for proteins, assays, substrates, inhibitors & antibodies

Antibodies for XRN2

GeneCards Homepage - Last full update: 2 Jul 2009 Incremental update: 13 Oct 2009

Random Gene From GIFtS :

about GIFtS

Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

Developed at the Crown Human Genome Center & Weizmann Institute of Science

The GeneCards Human Gene Database: Copyright © 1996-2009, Weizmann Institute of Science. All Rights Reserved.
XRN2 Gene at Home site.
Version 2.41.1
server4.xennexinc.com

XRN2 Gene

protein-coding GIFtS: 60

Aliases &
Descriptions
for XRN2

Summaries
for XRN2

Genomic Location
for XRN2

Proteins
for XRN2

Protein Domains/
Families
for XRN2

Gene Function
for XRN2

Pathways & Interactions
for XRN2

Drugs & Compounds
for XRN2

Transcripts
for XRN2

Expression
for XRN2

Orthologs
for XRN2

Paralogs
for XRN2

SNPs/Variants
for XRN2

Disorders & Mutations
for XRN2

Medical News
for XRN2

Publications
for XRN2

Search for XRN2

Genome Databases showing XRN2

Other Databases showing XRN2

Specialized Databases showing XRN2

Licensable Technologies
for XRN2

Services
for XRN2

Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

XRN2 Gene

protein-coding GIFtS: 60

Aliases & Descriptionsfor XRN2

Summariesfor XRN2

Genomic Locationfor XRN2

Proteinsfor XRN2

Protein Domains/Familiesfor XRN2

Gene Functionfor XRN2

Pathways & Interactionsfor XRN2

Drugs & Compoundsfor XRN2

Transcriptsfor XRN2

Expression for XRN2

Orthologsfor XRN2

Paralogsfor XRN2

SNPs/Variantsfor XRN2

Disorders & Mutationsfor XRN2

Medical Newsfor XRN2

Publicationsfor XRN2

Search for XRN2

Genome Databases showing XRN2

Other Databases showing XRN2

Specialized Databases showing XRN2

Licensable Technologiesfor XRN2

Servicesfor XRN2

Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

Aliases &
Descriptions
for XRN2

Summaries
for XRN2

Genomic Location
for XRN2

Proteins
for XRN2

Protein Domains/
Families
for XRN2

Gene Function
for XRN2

Pathways & Interactions
for XRN2

Drugs & Compounds
for XRN2

Transcripts
for XRN2

Expression
for XRN2

Orthologs
for XRN2

Paralogs
for XRN2

SNPs/Variants
for XRN2

Disorders & Mutations
for XRN2

Medical News
for XRN2

Publications
for XRN2

Licensable Technologies
for XRN2

Services
for XRN2