XRN2 Gene
protein-coding GIFtS: 59
GCID: GC20P021283
|
|
5'-3' exoribonuclease 2
| |
Aliases
for XRN2 gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| 5'-3' Exoribonuclease 21 2 | | DHP Protein2 3 | | Dhm1-Like Protein (Mouse Homolog)2 | | EC 3.1.13.-3 | | DHM1-Like Protein3 | | EC 3.1.138 |
Export aliases for XRN2 gene to outside databasesPrevious GC identifers: GC20P021272 GC20P021278 GC20P021231 |
Summaries
for XRN2 gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
Entrez Gene summary for XRN2:
This gene shares similarity with the mouse Dhm1 and the yeast dhp1 gene. The yeast gene is involved in homologousrecombination and RNA metabolism, such as RNA synthesis and RNA trafficking. Complementation studies show that Dhm1has a similar function in mouse as dhp1. The function of the human gene has not yet been determined. Transcriptvariants encoding different isoforms have been noted for this gene; however, their full-length nature is not known.(provided by RefSeq, Jul 2008)
UniProtKB/Swiss-Prot: XRN2_HUMAN, Q9H0D6Function: Possesses 5'->3' exoribonuclease activity (By similarity). May promote the termination of transcription byRNA polymerase II. During transcription termination, cleavage at the polyadenylation site liberates a 5' fragmentwhich is subsequently processed to form the mature mRNA and a 3' fragment which remains attached to the elongatingpolymerase. The processive degradation of this 3' fragment by this protein may promote termination of transcription
Gene Wiki entry for XRN2 (5'-3' exoribonuclease 2)
|
Genomic Views
for XRN2 gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000020.10 NC_018931.1 NT_011387.8
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the XRN2 gene promoter:
AP-2rep AML1a C/EBPalpha Egr-2 AREB6 CREB NRF-2 deltaCREB HSF2 c-Myb
Other transcription factors
Search SABiosciences Chromatin IP Primers for XRN2
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat XRN2 |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 20p11.2-p11.1 Ensembl cytogenetic band: 20p11.23 HGNC cytogenetic band: 20p11.2-p11.1XRN2 Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 20 GeneLoc Exon Structure GeneLoc location for GC20P021283: view genomic region
(about GC identifiers)
Start:
|
21,283,942 bp from pter |
End:
|
21,370,463 bp from pter |
Size:
|
86,522 bases |
Orientation:
|
plus strand |
|
Proteins
for XRN2 gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: XRN2_HUMAN, Q9H0D6 (See
protein sequence)Recommended Name: 5'-3' exoribonuclease 2 Size: 950 amino acids; 108582 Da
Subcellular location: Nucleus, nucleolus
Sequence caution: Sequence=AAR24369.1; Type=Frameshift; Positions=73; Sequence=BAA90934.1; Type=Erroneous initiation;
Secondary accessions: Q3L8N4 Q6KGZ9 Q9BQL1 Q9NTW0 Q9NXS6 Q9UL53Alternative splicing: 2 isoforms: Q9H0D6-1 Q9H0D6-2 (No experimental confirmation available)Explore the universe of human proteins at neXtProt for XRN2: NX_Q9H0D6
Post-translational modifications:
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_Q9H0D6
4/22 DME Specific Peptides for XRN2 (Q9H0D6) (see all 22)
XRN2 Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins: NP_036387.2
ENSEMBL proteins: ENSP00000366396 ENSP00000441113 ENSP00000413548 Reactome Protein details: Q9H0D6
Human Recombinant Protein Products:
Gene Ontology (GO): 3 cellular component terms (GO ID links to tree view): About this table
XRN2 for ontologies About GeneDecksing
XRN2 Antibody Products:
Assay Products for XRN2: |
Protein
Domains /
Families
for XRN2 gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
XRN2 for domains About GeneDecksing
4 InterPro domains/families:Graphical View of Domain Structure for InterPro Entry Q9H0D6ProtoNet protein and cluster: Q9H0D6 2 Blocks protein families: IPB001878 C2HC-type zinc-finger signature IPB004859 Putative 5-3 exonuclease domain
UniProtKB/Swiss-Prot: XRN2_HUMAN, Q9H0D6Similarity: Belongs to the 5'-3' exonuclease family. XRN2/RAT1 subfamilySimilarity: Contains 1 CCHC-type zinc finger |
Function
for XRN2 gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Function Summary:
UniProtKB/Swiss-Prot: XRN2_HUMAN, Q9H0D6Function: Possesses 5'->3' exoribonuclease activity (By similarity). May promote the termination of transcription byRNA polymerase II. During transcription termination, cleavage at the polyadenylation site liberates a 5' fragmentwhich is subsequently processed to form the mature mRNA and a 3' fragment which remains attached to the elongatingpolymerase. The processive degradation of this 3' fragment by this protein may promote termination of transcriptionCatalytic activity: Exonucleolytic cleavage in the 5'- to 3'-direction to yield nucleoside 5'-phosphates Genatlas biochemistry entry for XRN2:murine DHM1 gene homolog,5'-3' exoribonuclease 2,highly expressed in the testis,involved in homologous recomnbination
Enzyme Numbers (IUBMB): EC 3.1.13.-1 EC 3.1.132
Clone
Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for XRN2 (see all 4)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for XRN2
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling 
| |  | GenScript: all cDNA clones in your preferred vector: XRN2 (NM_012255) | |  | Browse Sino Biological Human cDNA Clones | |  | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for XRN2 | |  | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat XRN2 |
In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for XRN2 |
Gene Ontology (GO): 5 molecular function terms (GO ID links to tree view): About this table
XRN2 for ontologies About GeneDecksing
|
Pathways & Interactions
for XRN2 gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Unified GeneCards pathways About this table
See pathways by source
| Super-pathway | contained gene-specific pathways |
|---|
| 1 | Chaperonin-mediated protein folding | | | 2 | Ribosome biogenesis in eukaryotes | | | 3 | Deadenylation-dependent mRNA decay | | | 4 | mRNA Splicing - Major Pathway | | | 5 | Asparagine N-linked glycosylation | |
Pathway sources
See GeneCards unified pathways
Show all pathways
1  BioSystems Pathway for XRN2
4 
Reactome Pathways for XRN2
2 
Kegg Pathways (Kegg details for XRN2):
XRN2 for pathways About GeneDecksing
Interactions:
SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for XRN2
STRING Interaction
Network Preview (showing 5 interactants - click image to see 25)
5/806 Interacting proteins for XRN2 (Q9H0D62, 3 ENSP000003663964) via UniProtKB, MINT, STRING, and/or I2D (see all 806)| Interactant | Interaction Details |
|---|
| GeneCard | External ID(s) |
|---|
| UPF2 | Q9HAU52, 3, ENSP000003487084 | MINT-7945693 MINT-7947479 I2D:
score=4 STRING: ENSP00000348708 | | EEF1A1 | P681042, 3, ENSP000003300544 | MINT-7945693 MINT-7947479 I2D:
score=3 STRING: ENSP00000330054 | | EIF3L | Q9Y2622, 3, ENSP000004168924 | MINT-7945693 I2D:
score=3 STRING: ENSP00000416892 | | TARDBP | Q131482, 3, ENSP000002401854 | MINT-7945693 MINT-7947479 I2D:
score=4 STRING: ENSP00000240185 | | EXOSC10 | Q017802, 3, ENSP000003661354 | MINT-7945693 MINT-7947479 I2D:
score=4 STRING: ENSP00000366135 |
About this table
Gene Ontology (GO): 5/10 biological process terms (GO ID links to tree view) (see all 10): About this table
XRN2 for ontologies About GeneDecksing
|
Drugs & Compounds
for XRN2 gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
 Browse Tocris compounds for XRN2
Search CenterWatch for drugs/clinical trials and news about XRN2
|
Transcripts
for XRN2 gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for XRN2 gene: NM_012255.3 Unigene Cluster for XRN2: 5'-3' exoribonuclease 2 Hs.255932 [show with all ESTs]Unigene Representative Sequence: BC1429603 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000377191(uc002wsf.1 uc002wsg.1) ENST00000539513(uc010zsk.1 uc002wsh.1)
ENST00000430571
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for XRN2 (see all 4)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for XRN2
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector: XRN2 (NM_012255) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for XRN2 | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat XRN2 |
Additional cDNA sequence: AF064257.1 AF152169.1 AK000084.1 AK001573.1 AK172858.1 AK302846.1 AK303312.1 AK314602.1 AL136841.1 AY382900.1 BC000315.2 BC006417.1 BC032075.2 BC131775.1 BC142960.1 24 DOTS entries: DT.101976662 DT.416242 DT.102832941 DT.97847492 DT.439293 DT.100808866 DT.92062355 DT.75101626 DT.75168600 DT.100810382 DT.91805915 DT.91858750 DT.92409492 DT.95185286 DT.95221799 DT.100810389 DT.102832940 DT.102832943 DT.120807525 DT.95218276 DT.95221798 DT.95221814 DT.99961805 DT.99982457 24/379 AceView cDNA sequences (see all 379): AA314456 CB141497 AW242471 AW250130 AI372022 AW196349 BM451916 AI796426 BU620774 BX953011 BX383411 BU176486 BM729186 BU929425 BM765990 BX102929 AK000084 BE551504 BM783374 BQ226591 BM823036 AU125088 BQ644805 BQ440589
GeneLoc Exon Structure
5/7 Alternative Splicing Database (ASD) splice patterns (SP) for XRN2 (see all 7) About this scheme
| ExUns: | 1a | · | 1b | · | 1c | · | 1d | ^ | 2 | ^ | 3 | ^ | 4 | ^ | 5a | · | 5b | ^ | 6 | ^ | 7a | · | 7b | ^ | 8 | ^ | 9 | ^ | 10 | ^ | 11 | ^ | 12 | ^ | 13 | ^ | 14 | ^ | 15a | · | 15b | ^ | 16 | ^ | 17a | · | 17b | ^ | 18 | ^ | 19 | ^ |
|---|
|
| SP1: | | | | | | | | | - | | | | | | | | - | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | - | | | | | | |
| SP2: | | | | | | | | | - | | - | | | | | | - | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | - | | | | | | |
| SP3: | | | | | | | | | | | | | | | | | - | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | |
| SP4: | | | | | | | | | - | | - | | - | | - | | - | | - | | - | | - | | - | | - | | - | | - | | - | | - | | - | | - | | - | | - | | - | | - | | - | | - | | |
| SP5: | | | | | | | | | - | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | |
| ExUns: | 20 | ^ | 21 | ^ | 22 | ^ | 23a | · | 23b | ^ | 24 | ^ | 25 | ^ | 26 | ^ | 27 | ^ | 28 | ^ | 29 | ^ | 30 | ^ | 31a | · | 31b |
|---|
|
| SP1: | | | | | | | | | - | | | | | | | | | | | | | | | | | | | | |
| SP2: | | | | | | | | | - | | | | | | | | | | | | | | | | | | | | |
| SP3: | | | | | | | | | | | | | | | | | | | | | | | | | | | | | |
| SP4: | - | | - | | - | | - | | - | | - | | - | | - | | - | | - | | | | | | | | | | |
| SP5: | | | | | | | | | | | | | | | | | | | | | | | | | | | | |
ECgene alternative splicing isoforms for XRN2
|
Expression
for XRN2 gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| XRN2 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: CTGATTTTTA
About this image
See XRN2 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for XRN2
SOURCE GeneReport for Unigene cluster: Hs.255932
UniProtKB/Swiss-Prot: XRN2_HUMAN, Q9H0D6Tissue specificity: Expressed in the spleen, thymus, prostate, testis, ovary, small intestine, colon, peripheral bloodleukocytes, heart, brain, placenta, lung, liver, skeletal muscle, kidney, and pancreas. Isoform 2 is expressedpredominantly in peripheral blood leukocytes
SABiosciences Custom PCR Arrays for XRN2
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for XRN2
Browse OriGene validated miRNA SYBR primer pairs
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse, rat XRN2 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat XRN2 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat XRN2 | In Situ
Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for XRN2 |
Orthologs
for XRN2 gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of eukaryotes.
Orthologs for XRN2 gene from 10/34 species (see all 34) About this table
| Organism |
Taxonomic
classification |
Gene |
Description |
Human
Similarity |
Orthology
Type |
Details |
mouse
(Mus musculus) |
Mammalia |
Xrn21 , 5 |
5'-3' exoribonuclease 21, 5 |
92.35(n)1
96.11(a)1 |
|
2 (72.63 cM)5
241281 NM_011917.21 NP_036047.21
1470129965 |
chicken
(Gallus gallus) |
Aves |
XRN21 |
5'-3' exoribonuclease 2 |
78.92(n)
83.47(a) |
|
421236 NM_001031033.1 NP_001026204.1 |
lizard
(Anolis carolinensis) |
Reptilia |
XRN26 |
-- |
79(a) |
1 ↔ 1 |
4(81316733-81369927) |
tropical clawed frog
(Xenopus tropicalis) |
Amphibia |
Str.12102 |
Transcribed sequence with moderate similarity to protein more |
81.61(n) |
|
142003644 |
zebrafish
(Danio rerio) |
Actinopterygii |
idibd10902 |
Danio rerio mRNA similar to 5'-3' exoribonuclease 2 more |
74.74(n) |
|
BC047182.1 |
fruit fly
(Drosophila melanogaster) |
Insecta |
CG103543
Rat11 |
5'-3' exoribonuclease3
CG10354-PA1 |
44(a)
(best of 2)3
56.89(n)1
60.2(a)1 |
|
27C43
339641 NM_135238.21 NP_609082.11 |
worm
(Caenorhabditis elegans) |
Secernentea |
Y48B6A.33
xrn-21 |
Protein XRN-21 |
54(a)
(best of 2)3
57.75(n)1
58.52(a)1 |
|
II(14155604-14158131)3
1750711 NM_064557.41 NP_496958.21 |
baker's yeast
(Saccharomyces cerevisiae) |
Saccharomycetes |
RAT1(YOR048C)4
RAT11 |
Nuclear 5' to 3' single-stranded RNA exonuclease, involved more4
Rat1p1 |
53.12(n)1
47.45(a)1 |
|
15(421650-418630)4
8542131, 4 NP_014691.11, 4 |
thale cress
(Arabidopsis thaliana) |
eudicotyledons |
XRN31 |
5'-3' exoribonuclease 3 |
53.99(n)
48(a) |
|
843900 NM_106217.2 NP_565114.1 |
rice
(Oryza sativa) |
Liliopsida |
Os.193682 |
Oryza sativa (japonica cultivar-group) cDNA cloneJ more |
73.93(n) |
|
AK070933.1 |
ENSEMBL Gene Tree for XRN2 (if available)
TreeFam Gene Tree for XRN2 (if available) |
Paralogs
for XRN2 gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| -- |
Genomic Variants
for XRN2 gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 20 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for XRN2 (21283942 - 21370463 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 10 variations for XRN2
8 CNVs: 90503 79148 44043 39288 23622 102933 67669 61918
2 Indels: 12168 79149 | SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing XRN2 |
|
Disorders
/ Diseases
for XRN2 gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
XRN2 for disorders About GeneDecksing
OMIM gene information: 608851
OMIM disorders: --
5  diseases for XRN2: About MalaCardspharyngitis schizophrenia malaria prostatitis
neuronitis
Export disorders for XRN2 gene to outside databases
|
Publications
for XRN2 gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for XRN2 gene, integrated from 9 sources (see all 47):
(articles sorted by number of sources associating them with XRN2) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- Cloning and mapping of the XRN2 gene to human chromosome 20p11.1- p11.2. (PubMed id 10409438)1, 2, 3, 9 Zhang M.... Zhao S.Y. (1999)
- A novel splice variant of human XRN2 gene is mainly expressed in blood leukocyte. (PubMed id 16147866)1, 2, 9 Li J.... Mao Y. (2005)
- A probability-based approach for high-throughput protein phosphorylation analysis and site localization. (PubMed id 16964243)1, 2 Beausoleil S.A.... Gygi S.P. (2006)
- Pause sites promote transcriptional termination of mammalian RNA polymerase II. (PubMed id 16648491)1, 2 Gromak N.... Proudfoot N.J. (2006)
- Global, in vivo, and site-specific phosphorylation dynamics in signaling networks. (PubMed id 17081983)1, 2 Olsen J.V....Mann M. (2006)
- Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
- Human 5' -> 3' exonuclease Xrn2 promotes transcription termination at co-transcriptional cleavage sites. (PubMed id 15565158)1, 2 West S.... Proudfoot N.J. (2004)
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
- Functional proteomic analysis of human nucleolus. (PubMed id 12429849)1, 2 Scherl A.... Diaz J.-J. (2002)
- The DNA sequence and comparative analysis of human chromosome 20. (PubMed id 11780052)1, 2 Deloukas P....Rogers J. (2001)
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External Searches for XRN2 gene
(in PubMed,
OMIM, and NCBI Bookshelf)
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Genome Databases showing XRN2 gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
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Other Databases showing XRN2 gene
(According to HUGE)
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Specialized Databases showing XRN2 gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
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| Patent Information for XRN2 gene:
Search GeneIP for patents involving XRN2
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
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Products
for XRN2 gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
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| | |  | Browse OriGene Antibodies | | OriGene shRNA RFP for XRN2 | | | OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for XRN2 | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for XRN2 | | | OriGene Protein Over-expression Lysate for XRN2 | | Browse OriGene Fluorogenic Cell Assay Kits | | | OriGene siRNA for XRN2 | | OriGene 3'-UTR Clone for XRN2 | | | OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for XRN2 | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for XRN2 | | | Browse OriGene GFP tagged cDNA clones in CMV expression vector | | Browse OriGene MicroRNA Expression Plasmids | | | Browse OriGene basic RS shRNAs | | Browse OriGene validated miRNA SYBR primer pairs | | | OriGene Purified Protein for XRN2 | | OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling | | | OriGene Custom Antibody Services for XRN2 | | OriGene Custom Protein Services for XRN2 | | | OriGene Custom Immunoassay Development | | |
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| | | QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat XRN2 | | | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing XRN2 | | | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat XRN2 | | | QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat XRN2 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat XRN2 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat XRN2 |
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| | | | Search Tocris compounds for XRN2 |
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 | | | XRN2 Proteins, Antibodies, CLIAs, and ELISAs |
| | | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for XRN2 |
|  |  |  | | | | Search ThermoFisher Antibodies for XRN2 |
| | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat XRN2 |
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